17th week of 2022 patent applcation highlights part 23 |
Patent application number | Title | Published |
20220127161 | LIQUID PURIFIER - A purifier includes a housing, a filter, a supply flow path supplying water from a source to the filter, a supply valve on the supply flow path to regulate flow through the supply flow path, a nozzle provided outside of the housing, a purified liquid flow path to guide liquid from the filter toward the nozzle, a hot liquid flow path having one side branched from the purified liquid flow path and another side connected to the nozzle, a hot water module provided to heat liquid in the hot liquid flow path, a sterilization flow path having one side branched from the supply flow path and another side connected to the filter, a sterilization valve provided on the sterilization flow path to regulate flow through the sterilization flow path, and a sterilization module provided on the sterilization flow path to heat liquid in the sterilization flow path. | 2022-04-28 |
20220127162 | WATER PRESSURE MONITORING SYSTEM - A method and apparatus for monitoring a water pressure in a filter tank are disclosed. The apparatus may include a pressure sensor disposed within a housing and configured to monitor the water pressure in the filter tank. The apparatus may also include a controller disposed within the housing, the controller communicatively connected to the pressure sensor and the controller configured to receive a sensor signal from the pressure sensor, and to determine the water pressure in the filter tank based on the sensor. | 2022-04-28 |
20220127163 | DOSING PUMP FOR DOSING ANTISCALANT INTO A MEMBRANE-BASED WATER TREATMENT SYSTEM - A dosing pump ( | 2022-04-28 |
20220127164 | METHOD AND SYSTEM FOR THE REMEDIATION OF AQUATIC FACILITIES - A system and method for controlling the accelerated remediation of aquatic facilities using at least one sanitizer sensor, a pH sensor, a temperature sensor and a chlorine dioxide sensor all interfaced with a programmable controller that is programmed to implement a remediation cycle and configured to calculate a Ct value, the sensors being in fluid contact with water of the aquatic facility, and the programmable controller is interfaced with a chemical feed system for supplying chlorine dioxide to the water. | 2022-04-28 |
20220127165 | BRINE MANAGEMENT SYSTEM FOR ACHIEVING ZERO LIQUID DISCHARGE - Methods, apparatus, and systems for removing salt from brine are provided. A surfactant is mixed with the brines and the brines are atomized to form airborne brine droplets from which the liquid component can be rapidly evaporated. The remaining airborne salt particles are than filtered from the air stream and the water vapor condensed for collection and downstream use or processing. | 2022-04-28 |
20220127166 | SIMULTANEOUS OPTIMIZATION OF FUEL ENERGY, SITE OPEX, WASTE HEAT RECOVERY AND DIRTY WATER TREATMENT - Embodiments of the present disclosure relate generally to a system for simultaneous optimization of fuel energy, site Opex costs, waste heat recovery and the coincidental cleaning and treatment of dirty water. The system can include a waste heat source that generates waste heat. The system can include a hydrocyclone coupled with the waste heat source, wherein the waste heat is injected into the hydrocyclone. | 2022-04-28 |
20220127167 | SYSTEM AND METHOD FOR A HASH TABLE AND DATA STORAGE AND ACCESS USING THE SAME - The present teaching relates to method, system, medium, and implementations for storage management. A hash table is constructed, having an index file having one or more slots, each of which includes one or more buckets. Each bucket stores one or more types of records, including a direct record, an indirect record, and a forwarding record. A direct record stores data directly in a bucket of a slot of the index file. When a storage request is received related to some relevant data, the request is handled based on the constructed hash table. | 2022-04-28 |
20220127168 | INTEGRATED POWER SYSTEM - An exemplary power system utilizes turbines configured within a water intake conduit to the desalination processor to produce power for the desalination processor. Water intakes are configured to provide a natural flow of water to the desalination processor though hydrostatic pressure. One or more turbines coupled with the water intake conduits are driven and produce power for the system. The desalination processor incorporates Graphene filters to and may include a structured water system to increase the H3O2 concentration of the water prior to Graphene filters. Discharge water may be pumped back into the body of water but be separated from the intakes. A secondary power source, such as a renewable power source, may be used to produce supplemental power for the system. Power produced may be provided to a secondary outlet, such as a power grid, all above and/or underground. | 2022-04-28 |
20220127170 | SWIMMING POOL FILTER INCLUDING AN ANTI-PATHOGENIC DOSING ELEMENT CAPABLE OF AUTOMATICALLY DOSING - A swimming pool filter element capable of automatically dosing. The swimming pool filter element includes a folding filter element and a doser filter element. The folding filter element includes a filter membrane and end covers, the end covers each having an upper end cover and a lower end cover. A wrench cover is arranged at the upper end of the upper end cover. The doser filter element includes a doser end cover, a doser lining and a doser shell. The doser filter element is added into the folding filter element, so that a water flow needing to be filtered firstly passes through the filter membrane of the folding filter element, solid large-particle impurities are filtered out, then the water flow enters the doser filter element and makes contact with sterilization tablets placed in the doser filter element, the tablets are dissolved, and finally water with dissolved tablets is discharged into a swimming pool. | 2022-04-28 |
20220127172 | SYSTEMS AND METHODS FOR WATER TREATMENT AND STORAGE - This disclosure describes systems and methods for providing water to a user for consumption. Systems of the present disclosure can include a water management system including one or more a water treatment flow path for receiving source water, disinfection unit(s), additive unit(s), sensor(s) for maintaining various water conditions. Additionally, water management, treatment and/or storage systems including controller(s) and associated methods of operating are also described for dispensing water to a user. | 2022-04-28 |
20220127173 | SYSTEM AND METHOD FOR TOTAL VOLUME TREATMENT OF LANDFILL LEACHATE AND USE THEREOF - The present disclosure belongs to the technical field of treating landfill leachate, and in particular to a system and a method for total volume treatment of landfill leachate, and a use thereof. The system comprises an integrated device of dielectric barrier discharge combined with catalyst treatment, an SBR-MBR biochemical treatment device and a PLC control device; the integrated device for a discharge barriered by dielectric and a catalysis treatment is communicated with the SBR-MBR biochemical treatment device through a water transport pipeline, and the PLC control device is respectively connected with the integrated device for a discharge barriered by dielectric and a catalysis treatment and the SBR-MBR biochemical treatment device through connecting lines. | 2022-04-28 |
20220127174 | Wastewater Treatment Membrane Electro Membrane - In an apparatus for treating wastewater, water is screened, biologically treated and coagulated with the addition of chemicals before it is drawn through a membrane filter to produce permeate that is then passed through an electro-chemical cell to coagulate and/or oxidize residual contaminants such as phosphorous, nitrogen, or ammonia, and is then passed through a secondary membrane filter to capture and remove any remaining contaminants. | 2022-04-28 |
20220127175 | METHOD OF PURIFYING NATURAL WATER AND WASTEWATER - The invention is classified as a physicochemical method of natural and waste water treatment and can be used in the energy engineering, chemical, petrochemical, food and other industries, especially in treatment of process, domestic, precipitation, mining, oilfield, quarry water and the water of tailing pounds. | 2022-04-28 |
20220127176 | METHOD AND SYSTEM FOR TREATING WASTEWATER - This specification describes systems and methods for treating wastewater, for example digestate. The wastewater is separated into a liquid fraction and a solid fraction. The solid fraction of the wastewater is composted. The liquid fraction of the wastewater can be treated, which may result in further by-products. Optionally, at least some of the liquid fraction may be reused in the process. The by-products produced in treating the liquid fraction and/or additional organic solid waste, for example green waste, brought into the treatment facility can be added to the compost. The compost breaks down through aerobic and/or anaerobic digestion processes. Thermophilic conditions may develop in composting piles and increase the rate of evaporation of excess water. When sufficiently dry, the compost may be used as a fertilizer or soil enhancement product. | 2022-04-28 |
20220127177 | SEMICONDUCTOR PROCESS WASTEWATER TREATMENT SYSTEM AND SEMICONDUCTOR PROCESS WASTEWATER TREATMENT METHOD USING THE SAME - A semiconductor process wastewater treatment system and a semiconductor process wastewater treatment method using the same are disclosed. The disclosed semiconductor process wastewater treatment system may comprises: a processing unit configured to receive semiconductor process wastewater and treats the semiconductor process wastewater through a plurality of operations; and a membrane filtration tank arranged separately from the processing unit, the membrane filtration tank having a ceramic nano-membrane for filtering the semiconductor process wastewater which has passed through the processing unit, wherein the ceramic nano-membrane may include a carbon-based nano-material. The ceramic nano-membrane may include a graphene-based nano-material as the carbon-based nano-material. | 2022-04-28 |
20220127178 | FILTRATION APPARATUS AND METHOD - A filtration apparatus for filtrating particles from fluid, the filtration apparatus comprising a filtration vessel; at least one filtering element for removing particles from fluid passing therethrough, the at least one filtering element being arranged to move along a path into the filtration vessel, and out from the filtration vessel; a filtration inlet arranged to convey a mixture of particles and fluid to the at least one filtering element within the filtration vessel; and a filtration outlet arranged to convey fluid, filtrated by the at least one filtering element, out from the filtration vessel; wherein the filtration apparatus is configured to establish a differential pressure over the at least one filtering element inside the filtration vessel. A method of filtrating particles from fluid is also provided. | 2022-04-28 |
20220127179 | PROCESS TO MAKE TEXTURED GLASS - Systems and methods for texturing substrates (e.g., glass, metal, and the like) and the textured substrates produced using such systems and methods are disclosed. An exemplary textured substrate includes a surface having a portion with a root-mean-square roughness between 40 to 1000 microns and an autocorrelation function greater than 0.5 for distances less than 50 microns. An exemplary system for texturing a substrate includes a plunger with a textured surface, where a portion of the textured surface has a root-mean-square roughness between 40 to 1000 microns and an autocorrelation function greater than 0.5 for distances less than 50 microns. An exemplary method for texturing a substrate includes the steps of generating a pattern defining a texture, and 3-D printing the pattern on the substrate to form the texture. | 2022-04-28 |
20220127180 | METHODS OF PROCESSING A VISCOUS RIBBON - Methods of processing a viscous ribbon include supplying a molten material from a supply vessel. Methods include forming the molten material into the viscous ribbon. The viscous ribbon travels along a travel path. Methods include receiving thermal light energy produced from the viscous ribbon. Methods include generating an image of the viscous ribbon from the thermal light energy. Methods include detecting a defect of the viscous ribbon from the image. | 2022-04-28 |
20220127181 | MANUFACTURING APPARATUS AND MANUFACTURING METHOD OF POROUS GLASS BASE MATERIAL - A manufacturing apparatus of porous glass base material includes deposition apparatuses that manufacture a porous glass base material by generating raw material particles from vaporized raw material compounds in an oxyhydrogen flame, and then depositing the generated raw material particles on a rotating starting material. The manufacturing apparatus includes a storage container that stores liquid raw material compounds for each compound, a vapor generation mechanism that vaporizes the raw material compounds, and a gas channel that supplies the vaporized raw material compounds to the deposition apparatuses. The gas channel includes a common gas channel shared to supply vaporized raw material compounds to the plurality of deposition apparatuses, and individual gas channels branched off from the common gas channel to supply vaporized raw material compounds to each of the deposition apparatuses individually. Each of the individual gas channels has a flow controller, a steam valve, and a valve. | 2022-04-28 |
20220127182 | TUMBLED, POLISHED, VIBRATED BROKEN TEMPERED GLASS PIECES - An invention is provided for creating smoothed, heat-treated glass fragments. The invention includes placing a plurality of heat-treated glass fragments into a tumbling or vibrating apparatus. Each heat-treated glass fragment is formed from glass that has been heated to a temperature of at least 1000° Fahrenheit and rapidly cooled to a temperature below 800° Fahrenheit. The plurality of glass fragments is then tumbled or vibrated for a predetermined period of time such that surfaces of the heat-treated glass fragments are smoother than prior to tumbling. The glass fragments are thereafter removed from the tumbling apparatus, resulting in smoothed, heat-treated glass fragments that have a slightly rounded, bead like-shape and are suitable for direct handling without hand protection. The glass fragments as are able to be provide radiant heat in the temperature range of 400° to 800° Fahrenheit. This temperature range and the use of the heat-treated glass fragments provides for a clean burning fire that virtually eliminates any soot and carbon monoxide while burning. | 2022-04-28 |
20220127183 | METHOD AND DEVICE FOR MANUFACTURING AN OPTICAL FIBRE - A method for manufacturing an optical fibre, in which a preform is inserted into a furnace, the preform is drawn via an outlet of the furnace, and at least one laser beam is applied to a working zone of the drawn preform, each laser beam being power-modulated according to a modulation frequency. A device for manufacturing an optical fibre is also provided. | 2022-04-28 |
20220127184 | PHOTOCHROMIC GLASS AND PHOTOCHROMIC GLASS WINDOWS - A photochromic glass, comprising: (i) a glass matrix that, comprising in mol percent (mol %) based on oxides: 66 mol %≤SiO | 2022-04-28 |
20220127185 | INFRARED-TRANSMITTING GLASS - Provided is a thermally stable and inexpensive infrared-transmitting glass. An infrared-transmitting glass contains, in terms of % by mole, over 0 to 9% Ge, over 0 to 50% Ga, 50 to 90% Te, 0 to 40% Si+Al+Ti+Cu+In+Sn+Bi+Cr+Sb+Zn+Mn+Cs+Ag+As+Pb, and 0 to 40% F+Cl+Br+I. | 2022-04-28 |
20220127186 | METHOD FOR MANUFACTURING ULTRA-THIN GLASS SUBSTRATE AND METHOD FOR MANUFACTURING DISPLAY PANEL - A method for manufacturing an ultra-thin glass substrate includes: providing a glass base material preset with n substrate areas and a skeleton area surrounding the substrate areas; at least forming an etching protection layer on an upper surface and a lower surface of each substrate area of the glass base material, respectively; at least etching the skeleton area of the glass base material to separate the substrate areas from the glass base material, and form a stress dissipation edge along an edge of each substrate area; and removing the etching protection layer to get independent glass substrates. A method for manufacturing a display panel is also disclosed. An aim is to prevent quality of the ultra-thin glass substrate from damage caused by scribing wheel cutting or laser cutting, therefore the quality of the ultra-thin glass substrate is improved. | 2022-04-28 |
20220127187 | AUTOMOTIVE GLAZING HAVING SUPERIOR OPTICAL QUALITY - A method for producing an automotive glazing with an optical sensor device, with the glazing having superior optical qualities, including the steps of applying an enamel obscuration mask on at least one face of at least one glass sheet, where the obscuration mask extends to an area where the at least one optical sensor device will be fixed and includes at least one opening on the automotive interior side so as to be capable of acquiring information through the opening from the optical sensor device intended to be fixed at the at least one opening; drying or firing the enamel obscuration mask; applying a washable cover layer resisting at a temperature of at least 620° C. on the surface of the at least one opening; submitting the glass sheet to a heat treatment above 450° C. during a bending or tempering process; and removing by washing the washable cover layer. | 2022-04-28 |
20220127188 | SOLAR CONTROL FILM WITH IMPROVED MOISTURE RESISTANCE FUNCTION AND MANUFACTURING METHOD THEREOF - A solar control film with improved moisture resistance function is provided. The solar control film includes a flexible substrate, at least one infrared-reflective composite layer and an outer dielectric layer. The infrared-reflective composite layer includes a dielectric sublayer and a metal sublayer. The dielectric sublayer is disposed on the flexible substrate, and the material of the dielectric sublayer includes TiO | 2022-04-28 |
20220127189 | GLAZING UNIT WITH FREQUENCY SELECTIVE COATING AND METHOD - An improved a glazing unit including a glass panel which is low in reflectance for RF radiation, a coating system which is high in reflectance for RF radiation disposed on the said glass panel and creating onto the glazing unit a dual band bandpass filter. The glazing unit further includes at least one frequencies selective decoated portion of the coating system extending along a plane, P, defined by a longitudinal axis, X, and a vertical axis, Z; having a width, DW, measured along the longitudinal axis, X, and a length, DL, measured along the vertical axis, Z. The at least one frequencies selective decoated portion includes a first decoated element that includes a plurality of unit cells forming a regular grid of n rows by m columns unit cells and a plurality of second decoated elements. | 2022-04-28 |
20220127190 | METHOD FOR OBTAINING A SUBSTRATE COATED WITH A FUNCTIONAL LAYER - A process for obtaining a material including a substrate coated on one of its sides with a coating including a functional layer, includes depositing the functional layer on the substrate, then depositing an absorbent layer on top of the functional layer, then performing a heat treatment by radiation, the radiation having at least one treatment wavelength between 200 and 2500 nm, the absorbent layer being in contact with air during the heat treatment, wherein the ab sorb ent layer ab sorbs at least 80% of the radiation used during the heat treatment and transmits less than 10% thereof. | 2022-04-28 |
20220127191 | GLASS SUBSTRATE, COVER GLASS, ASSEMBLY, ASSEMBLY MANUFACTURING METHOD, IN-VEHICLE DISPLAY DEVICE, AND IN-VEHICLE DISPLAY DEVICE MANUFACTURING METHOD - A glass substrate includes a thin portion having a first surface and a second surface opposed to the first surface, a thick portion having a first surface and a second surface opposed to the first surface and having a sheet thickness t | 2022-04-28 |
20220127192 | Cement Production - The present invention provides a method and system for manufacturing cement wherein ground particles of cement and calcium sulfate are subjected to infrared sensors, laser sensors, or both, so that emanated, irradiated, transmitted, and/or absorbed energy having wavelengths principally within the range of 700 nanometers to 1 millimeter can be monitored and compared to stored data previously obtained from ground cement and sulfate particles and preferably correlated with stored strength, calorimetric, or other data values, such that adjustments can be made to the mill processing conditions, such as the form or amounts of calcium sulfate (e.g., gypsum, plaster, anhydride), or cement additive levels. The strength and other properties of cement can be thus adjusted, and its quality can be more uniform. | 2022-04-28 |
20220127193 | MOISTURE MANAGEMENT IN VERTICAL ROLLER MILLS - Disclosed are exemplary method and system for manufacturing cement in a vertical roller mill (VRM) using humidity sensor readings. This enables adjustment of operational variables such as material feed, water, grinding additives, air flow, temperature, and their combinations. Exemplary embodiments allow manufacturers to predict and to improve cement properties, such as strength and setting time, by monitoring and managing humidity of air in the VRM and/or its air flow system. | 2022-04-28 |
20220127194 | CEMENTITIOUS COMPOSITIONS COMPRISING RECYCLED SUPERABSORBENT POLYMER - A cementitious composition including recycled superabsorbent polymer (RSAP) and a cementitious material. The RSAP has a purity level of at least 85 percent by weight of the RSAP. Also provided is a cementitious composition where the RSAP has substantially low levels of one or more residual drug entities. Also provided is a method for the construction of a self-sealing cement sheath, the method comprising: supplying a self-sealing slurry of a cementitious composition including cementitious material, an aqueous fluid, and RSAP into an underground geological formation, and allowing the self-sealing slurry of the cementitious composition to cure, thereby forming the self-sealing cement sheath. The RSAP is capable of swelling in the presence of fluid to seal any cracks formed in the self-sealing slurry during curing. | 2022-04-28 |
20220127195 | USE OF AN ACIDIC SALT OF IRON (III) AS ADDITIVE FOR CEMENT, MORTAR OR CONCRETE - A method includes adding an acidic salt of Iron (III) as additive to cement, mortar or concrete. | 2022-04-28 |
20220127196 | PROCESS FOR FIREPROOFING MATERIALS - A process for fireproofing materials, using the following steps:
| 2022-04-28 |
20220127197 | MULTIPHASE CERAMIC MATERIAL WITH GIANT DIELECTRIC CONSTANT, AND PREPARATION METHOD THEREOF - The present invention discloses a multiphase ceramic material with a giant dielectric constant, wherein the multiphase ceramic material has a general formula of A | 2022-04-28 |
20220127198 | Process for Improving Flash Sintering of Ceramics and Improved Ceramics - Methods of flash sintering have been developed in which particle are initially coated with thin layers by atomic layer deposition (ALD). Examples are provided in which 8 mol % yttria-stabilized zirconia (8YSZ) particles are coated with small quantities of Al | 2022-04-28 |
20220127199 | Multiple Crystallization Enhance (MCE) Intermix for Portland Cement Concrete - A water-based mixture of multi compounds for adding to fresh concrete to protect the concrete against moisture and moisture-associated problems. A hygroscopic and hydrophilic behavior of its crystallization system within a concrete matrix minimizes moisture transmission through capillaries and connected voids. As a result, the mixture may reduce moisture related problems, such as damage caused by repeated freeze and thaw cycles and chloride ion penetration as from deicing salts, as well as alkali-silica reactions, and other problems. | 2022-04-28 |
20220127200 | MATERIALS FOR SELECTIVE SINTERING OF COHESIVE FEEDSTOCKS - A method of forming three-dimensional objects includes depositing a sinterable, dense feedstock comprising a sinterable material and binder onto a surface, depositing a sintering selectivity material according to a pattern, removing the binder, sintering the sinterable, dense feedstock to form a three-dimensional sintered object, and finishing the sintered object. A sintering-selectivity material includes a solvent, and a sintering-selectivity material in the solvent, the sintering-selectivity material having the characteristic of being able to penetrate a dense feedstock. A system has a surface, a feedstock deposition head arranged to deposit a sinterable, dense feedstock on the surface, a sintering-selectivity deposition head arranged to deposit a sintering-selectivity material on at least one of the surface and the feedstock, a debinding mechanism arranged to debind the feedstock from the binder, and a sintering chamber to sinter the feedstock after debinding. | 2022-04-28 |
20220127201 | Glazing Material - A glazing material for producing a glazed ceramic body, in which at a first temperature T | 2022-04-28 |
20220127202 | PROCESS FOR OBTAINING A LIQUID FOLIAR FERTILIZER AND LIQUID FOLIAR FERTILIZER COMPOSITION - The present invention refers to a process for providing a liquid fertilizer for foliar application with a final formulation comprising ricinoleic acid saponified with sulfuric acid, triethanolamine and water. The invention provides a means of accelerating vegetative growth through a proposed composition that has a group of fatty acids and amino acids essential to plant development. The invention also provides foliar metabolic regulatory means without the presence of toxic components, being suitable for foliar application in all kinds of crops. | 2022-04-28 |
20220127203 | SPECIAL CONTROLLED-RELEASE MICROBIAL FERTILIZER FOR PEANUTS IN CONTINUOUS CROPPING FIELD AND PREPARATION METHOD THEREOF - The invention relates to the technical field of agricultural planting, in particular to a special controlled-release microbial fertilizer for peanuts in a continuous cropping field and a preparation method thereof. The fabric comprises an outer layer, a middle layer and an inner layer. Through a three-layer structure, the controlled-release fertilizer prepared by the disclosure can realize the fertilizer efficiency period of 50-60 days, and achieves the purpose of twice releases. | 2022-04-28 |
20220127204 | SPECIAL CONTROLLED-RELEASE BACTERIAL FERTILIZER FOR PEANUTS AND PREPARATION METHOD THEREOF - The invention relates to the technical field of agricultural planting, in particular to a controlled-release bacterial fertilizer for peanuts and a preparation method of the special controlled-release bacterial fertilizer. The special controlled-release bacterial fertilizer is composed of an inner layer and an outer layer; after the outer layer is released completely, the inner-layer network structure gradually absorbs water and preserves moisture, and has good slow release and controlled release properties, thereby achieving the gradual release of the inner layer, high fertilizer utilization rate, exerting the efficacy of the microbial agent and facilitating the large-area promotion. | 2022-04-28 |
20220127205 | SPRAY COMPOSITION OF AVERSIVE AGENT - The present invention relates to a composition comprising bittering agent for defense against human or animal attacker. The present invention more particularly relates to a composition comprising denatonium compound for self-defense, method of making and use of said composition as a personal protectant against human or animal attacker. | 2022-04-28 |
20220127206 | METHOD FOR INTRODUCING DEUTERATED LOWER ALKYL INTO AMINE MOIETY OF COMPOUND CONTAINING SECONDARY AMINE - The present invention relates to a method of mono-deuterated-lower-alkylating the amine part in a compound having an amine protected with an aralkyl, which comprises introducing mono-deuterated lower-alkyl into the amine with a deuterated-lower-alkylating agent under neutral or basic condition, and then deprotecting the aralkyl group. | 2022-04-28 |
20220127207 | CATALYZED PROCESS FOR THE DIMERIZATION OF ALKENES - The present invention relates to a process for the dimerization of alkenes comprising (1) providing a gas stream comprising one or more alkenes; and (2) contacting the gas stream provided in (1) with a catalyst for obtaining a mixture M1 comprising one or more dimerization products of the one or more alkenes, wherein the catalyst in (2) comprises a zeolitic material having a framework structure type selected from the group consisting of MOR, BEA, FER, MFI, TON, FAU, and mixtures of two or more thereof, wherein the framework structure of the zeolitic material comprises YO | 2022-04-28 |
20220127208 | DIMERIZATION AND TRIMERIZATION OF C5 OLEFINS VIA CATALYTIC DISTILLATION - A process for the selective dimerization and etherification of isoolefins. The process including feeding a mixed C5 stream to a selective hydrogenation unit to convert dienes to olefins and isoolefins, producing a hydrogenated effluent stream. The hydrogenated effluent stream is fed to a first fixed bed reactor, producing a first reactor effluent. The first reactor effluent is fed to a catalytic distillation reactor system, producing a first overheads including unreacted olefins, isoolefins, oxygenate, and one or more C5 ethers and a first bottoms including dimers of the isoolefins, any produced trimers of the isoolefins, and heavy oxygenates. The first overheads is fed to a second fixed bed reactor, producing a second reactor effluent including dimers of the isoolefins, unreacted C5s, and unreacted oxygenates. The first bottoms stream and the second reactor effluent are combined and fed to a product splitter, producing a second overheads stream including unreacted C5 olefins, isoolefins, and oxygenates and a second bottoms stream including C10+ hydrocarbons. | 2022-04-28 |
20220127209 | USE OF RENEWABLE ENERGY IN OLEFIN SYNTHESIS - An olefin synthesis plant comprising: a feed pretreatment section configured to pretreat a feed stream; a pyrolysis section comprising one or more pyrolysis reactors configured to crack hydrocarbons in the feed stream in the presence of a diluent to produce a cracked gas stream; a primary fractionation and compression section configured to provide heat recovery from and quenching of the cracked gas stream; remove a component from the cracked gas stream; and compress the cracked gas stream, thus providing a compressed cracked gas stream; and/or a product separation section configured to separate a product olefin stream from the compressed cracked gas stream, wherein the olefin synthesis plant is configured such that, relative to a conventional olefin synthesis plant, more of the energy and/or the net energy required by the olefin synthesis plant and/or one or more sections thereof, is provided by a non-carbon based and/or renewable energy source and/or electricity. | 2022-04-28 |
20220127210 | METHOD FOR SEPARATING OLEFIN OLIGOMERIZATION PRODUCTS (VARIANTS) - The invention relates to the field of olefin oligomerization to obtain liner α-olefins, particularly to a method of separating olefin oligomerization products using an evaporator. The invention includes two embodiments of the method of separating the oligomerization reaction product streams. In accordance with the first embodiment of the invention, the oligomerization reaction product stream after the step of isolating an initial olefin is fed into an evaporator to the step of separating the oligomerization reaction product steam. In accordance with the second embodiment of the invention, the oligomerization reaction product stream after the step of isolating the initial olefin is separated into two streams, the first part of which is fed into the separation column, and the second part is fed into the evaporator. The invention allows to minimize a quantity of technological equipment contaminated by the by-product polymer. | 2022-04-28 |
20220127211 | SYSTEM AND PROCESS FOR RECOVERING METHANE AND CARBON DIOXIDE FROM BIOGAS AND REDUCING GREENHOUSE GAS EMISSIONS - Various illustrative embodiments of a system and process for recovering high-quality biomethane and carbon dioxide product streams from biogas sources and utilizing or sequestering the product streams are provided. The system and process synergistically yield a biomethane product which meets gas pipeline quality specifications and a carbon dioxide product of a quality and form that allows for its transport and sequestration or utilization and reduction in greenhouse gas emissions. The system and process result in improved access to gas pipelines for products, an improvement in the carbon intensity rating of the methane fuel, and improvements in generation of credits related to reductions in emissions of greenhouse gases. | 2022-04-28 |
20220127212 | METHOD FOR PREPARATION OF 1,4-CYCLOHEXANEDIMETHANOL - The present disclosure relates to a method for preparation of 1,4-cyclohexanedimethanol. According to the present disclosure, two step reduction reactions are conducted using terephthalic acid as starting material, and an isomerization process for increasing the rate of trans isomers of CHDA is introduced therebetween, thereby providing a method capable of stably preparing CHDM with high rate of trans isomers. | 2022-04-28 |
20220127213 | METHOD FOR SELECTIVE SEPARATION, ISOLATION AND RECOVERY OF CANNABIDIOL AND CANNABIDIOL-LIKE MEROTERPENE ACIDS FROM COMPLEX MATRICES - Described is a method of selectively isolating non-rigid structure meroterpenes (for example, cannabidiolic acid) from a complex matrix that may also contain rigid structure meroterpenes (for example, THCa), comprising selectively precipitating the non-rigid structure meroterpenes in the form of a triethylamine salt complex by adding triethylamine; isolating the triethylamine salt complex from the mother liquor; then heating the triethylamine salt complex to vaporize the triethylamine, leaving an isolated neutral non-rigid structure meroterpene. In certain embodiments, the starting product is a | 2022-04-28 |
20220127214 | Method of Preparing 8-Methyldecanal - The present invention discloses a novel method of preparing 8-methyldecanal, a flavor and fragrance material. Specifically, starting from cheap and readily available material 6-chloro-1-hexanol, first, the hydroxyl group was protected with dihydropyran catalyzed by para-toluene sulfonic acid to produce 6-chloro-hexyl tetrahydropyran ether. Then 6-chloro-hexyl tetrahydropyran ether reacted with magnesium turnings to form a Grignard reagent and reacted with 1-bromo-2-methyl-butane under the catalysis of cuprous bromide to give the intermediate 8-methyl-sunny tetrahydropyran ether. Without purification, crude 8-methyl-sunny tetrahydropyran ether was treated under acidic conditions to remove the protecting group to generate 8-methyl-1-decyl alcohol. Finally, 8-methyl decanal was obtained after oxidation with 2, 2, 6, 6-tetramethylpiperidinyloxy. The novel method of preparing 8-methyldecanal disclosed in the present invention utilizes common raw materials with low costs, the reaction conditions are mild, and yield is high. It is suitable for large-scale production. | 2022-04-28 |
20220127215 | A COPPER-CATALYZED METHOD AND APPLICATION FOR PREPARING ALDEHYDES OR KETONES BY OXIDIZING ALCOHOLS WITH OXYGEN AS AN OXIDANT - The present invention discloses a method for preparing aldehydes or ketones via aerobic oxidation of alcohols with the copper salts and nitroxide radicals as catalysts. Both oxygen and air could be used as oxidants, after 4 to 48 hours of reaction in an organic solvent at room temperature, the alcohols are efficiently oxidized to the corresponding aldehydes or ketones. The present invention has the following advantages: easy to operate, refraining from using chlorides which are corrosive to equipment, readily available raw materials and reagents, mils reaction conditions, the broad substrate scope, good functional group tolerance, convenient purification, environmentally friendly and no pollution. Thus, the method is suitable for industrial production. | 2022-04-28 |
20220127216 | PRODUCTION METHOD FOR 4-HYDROXY-2-METHYLBENZOIC ACID - An object is to provide a novel production method for 4-hydroxy-2-methylbenzoic acid that is suitable for industrial use. As a solution, a production method for 4-hydroxy-2-methylbenzoic acid that includes performing a step (I) of reacting a compound represented by general formula (1) with carbon dioxide to obtain a compound represented by general formula (2), and then a step (II) of dealkylating the compound represented by general formula (2), is provided. | 2022-04-28 |
20220127217 | METHODS OF DEPOLYMERIZING LIGNIN - Methods of depolymerizing lignin and products obtained therefrom. The methods include reacting lignin in a liquid solvent comprising an oxidation catalyst with the solvent being in contact with 02 gas. The solvent can include aprotic polar solvents. The oxidation catalyst can include heterogeneous catalysts. The methods can be used in the oxidative catalytic fractionation of raw biomass to generate soluble aromatic monomers and a solid carbohydrate residue. Depolymerized lignin products include phenolic and benzoquinone monomers, such as p-hydroxybenzoic acid, vanillin, syringaldehyde, vanillic acid, and/or syringic acid. | 2022-04-28 |
20220127218 | METHOD FOR PRODUCING HYDROXYCARBOXYLIC ACID ESTER - An object of the present invention is to provide a method for selectively producing a hydroxycarboxylic acid ester, the method including reducing a dicarboxylic acid monoester by means of a heterogeneous reaction. According to a method for producing a hydroxycarboxylic acid ester in an embodiment of the present invention, a hydroxycarboxylic acid ester represented by Formula (2) is produced by reducing a substrate dicarboxylic acid monoester represented by Formula (1) in the presence of a catalyst. | 2022-04-28 |
20220127219 | ELECTROLYTE AND COMPOUND FOR THE ELECTROLYTE AND CAPACITOR - An electrolyte is provided, which includes organic solvent; and (1) a compound and an ammonium salt thereof, (2) a diacid and an ammonium salt thereof, or (3) a combination thereof. The compound has a chemical structure of | 2022-04-28 |
20220127220 | COMPOUNDS AND METHODS FOR TREATING INFLUENZA - A compound including a structure of Formula (I) and a preparation method thereof, | 2022-04-28 |
20220127221 | CRYSTAL COMPOSITION (CC) COMPRISING 4,4'-DICHLORODIPHENYLSULFOXIDE CRYSTALS (C) - The invention relates to a crystal (C) consisting of at least 95% by weight of 4,4′-dichlorodiphenylsulfoxide, 0 to 2% by weight of impurities and 0 to 3% by weight of an organic solvent (os). Moreover, the present invention relates to a crystal composition (CC) comprising crystals (C) and a process for the production of the crystal composition (CC) and the crystal (C). | 2022-04-28 |
20220127222 | PROCESS FOR PREPARING A COMPOUND OF FORMULA RSH BY HYDROSULFURIZATION - A method for preparing a compound of formula RSH where R represents an alkyl group, by gas-phase catalytic reaction of hydrogen sulfide with a compound of formula ROH, in the presence of a solid catalyst, according to which method the reaction is performed in the presence of a catalyst which includes one or several pure or mixed rare-earth oxide(s), one or several pure or mixed rare-earth sulfide(s), or one or several pure or mixed rare-earth oxysulfide(s). When the rare earth is lanthanum, the catalyst is a mixed oxide of lanthanum and of at least one metal selected from rare earths or not and when the rare earth is cerium, the catalyst is supported on an alumina. | 2022-04-28 |
20220127223 | AGENT FOR INITIATING A RADICAL ADDITION REACTION AND PROCESS USING IT - An agent for initiating a radical addition reaction includes a persulfate and one or more transition metals, in elemental form or in an oxidized form, as well as a method for preparing a compound of formula (I) | 2022-04-28 |
20220127224 | ANTIMICROBIAL AND ANTIVIRAL SULFUR CONTAINING GLYCEROL MONOESTER DERIVATIVES - The disclosure relates generally novel sulfur containing glycerol mono-ester derivatives and methods useful for treating gram positive, gram negative, fungal and envelope viral infections in a patient. | 2022-04-28 |
20220127225 | ONIUM SALT, CHEMICALLY AMPLIFIED RESIST COMPOSITION AND PATTERNING PROCESS - An onium salt having formula (1) serving as an acid diffusion inhibitor and a chemically amplified resist composition comprising the acid diffusion inhibitor are provided. When processed by lithography, the resist composition forms a pattern having minimal defects and excellent lithography performance factors such as CDU, LWR and DOF. | 2022-04-28 |
20220127226 | ANTI-ARRHYTHMICITY AGENTS - Agents, compositions, and methods for regulating cardiac rhythmicity are disclosed. | 2022-04-28 |
20220127227 | Aza (Indole)-, Benzothiophene-, And Benzofuran-3-Sulfonamides - Disclosed are sulfonamide compounds with GPR17 modulating properties, which are useful for treating or preventing a variety of CNS and other diseases, in particular for preventing and treating myelinating diseases or disorders. | 2022-04-28 |
20220127228 | METHOD FOR PRODUCING DICHLORO ADDITION PRODUCT OF ALIPHATIC OLEFIN BY PHOTOCATALYSIS UNDER VISIBLE LIGHT - The invention provides a method for producing a dichloro addition product of an aliphatic olefin by photocatalysis under visible light. The method includes reacting an aliphatic olefin as a substrate with hydrochloric acid as a chlorine source in an organic solvent under visible light irradiation in the presence of copper chloride with visible light absorption ability as a catalyst, to obtain the dichloro addition product of the aliphatic olefin, wherein the reaction is carried out under an oxygen-containing atmosphere, the aliphatic olefin comprises a carbon-carbon double bond and a C9-C15 aliphatic chain connected to the carbon-carbon double bond by a covalent bond. In the invention, visible light is used to provide the energy and a transition metal chloride with visible light absorption ability is used to undergo light-induced electron transfer from chloride with a reaction substrate, thereby initiating an addition reaction to obtain a dichloro addition product. | 2022-04-28 |
20220127229 | SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES - Disclosed are compounds of Formula 1, N-oxides of the compounds and salts of the compounds and N-oxides: | 2022-04-28 |
20220127230 | Intermediates for Optically Active Piperidine Derivatives and Preparation Methods Thereof - A preparation method according to the present invention makes it possible to industrially produce large amounts of highly pure optically active tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate in high yield by use of commercially available reagents and solvents. In addition, the use of novel intermediates according to the present invention makes it possible to produce highly pure optically active tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate in high yield. | 2022-04-28 |
20220127231 | PROCESS FOR THE PREPARTION OF AMIFAMPRIDINE PHOSPHATE - The present invention relates to an improved process for the preparation of substantially pure Amifampridine phosphate | 2022-04-28 |
20220127232 | HISTONE ACETYLTRANSFERASE MODULATORS AND COMPOSITIONS AND USES THEREOF - Compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject. | 2022-04-28 |
20220127233 | SUBSTITUTED QUINOLINYLCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION - The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds. | 2022-04-28 |
20220127234 | NOVEL CRYSTALLINE FORM OF IVACAFTOR AND A PROCESS FOR PREPARING THE SAME - In certain aspects, the invention provides crystalline forms of ivacaftor N-(2,4-di-tert-butyl-phenyl-5-hydroxy-phenyl)-1,4-dihydro-4-oxoquinoline-3-carboxamide. In related aspects, the invention provides a process for preparing any one of crystalline forms S2, S3, S4 and S5 of ivacaftor. The process includes: forming a solution including crude ivacaftor and a solvent; adding an anti-solvent to the solution to form slurry including a precipitate; isolating the precipitate; and drying the precipitate to provide crystalline form S2, S3, S4, or S5 of ivacaftor. | 2022-04-28 |
20220127235 | A CONTINUOUS FLOW MICRO-TOTAL PROCESS SYTEM FOR PREPARATION OF CELCOXIB AND ANALOGS THEREOF - The present invention relates to preparation of pyrazoles. This invention further relates to a continuous flow micro-total process system for preparation of celecoxib, a COX-2 selective non-steroidal anti-inflammatory drug, and analogs thereof. | 2022-04-28 |
20220127236 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PYRAZOLE DERIVATIVES - The invention provides a process for manufacturing 5-ethyl-4-methyl-N-[4-[(2S) morpholin-2-yl]phenyl]-1H-pyrazole-3-carboxamide (Formula I), or a pharmaceutically acceptable salt thereof, on an industrial scale, | 2022-04-28 |
20220127237 | FLUORESCENT PYRAZINE DERIVATIVES AND METHODS OF USING THE SAME IN ASSESSING RENAL FUNCTION - The present invention relates to pyrazine derivatives such as those represented by Formulas I and II. X | 2022-04-28 |
20220127238 | PROCESS FOR THE PREPARATION OF ANGIOTENSIN II RECEPTOR BLOCKERS - A process is disclosed for preparing sartan drugs including intermediates thereof, which avoids formation of Nitrosoamine impurities. | 2022-04-28 |
20220127239 | GLYCOSYL DONOR, PREPARATION METHOD THEREFOR, AND USE THEREOF - A glycosyl donor represented by formula (I) is used for preparing an S-glycoside compound represented by formula (III), an O-glycoside compound represented by formula (V), and a C-glycoside compound represented by formula (V). The glycosyl donor is a raw material in the preparation of O-glycoside, S-glycoside, and C-glycoside compounds by means of a free radical reaction, most of which have a special α configuration. | 2022-04-28 |
20220127240 | PRODRUGS OF UROLITHINS AND USES THEREOF - The invention provides compounds of formula (I) or salts thereof: | 2022-04-28 |
20220127241 | METHOD FOR THE PREPARATION OF THIOCARBONATES - A process can be used for the preparation of a compound with at least one five-membered cyclic monothiocarbonate group. The process involves a) using a compound with at least one epoxy group as starting material; b) reacting the compound with phosgene or an alkyl chloroformate, thus giving an adduct; and c) reacting the adduct with a compound containing anionic sulfur, thus obtaining the compound with at least one five-membered cyclic monothiocarbonate group. | 2022-04-28 |
20220127242 | N-LIPOIC-AMINO ACID OR PEPTIDE, DERIVATIVES AND THEIR USES - Novel compounds of N-Lipoic-amino acid, N-Lipoic-peptides and their derivatives are described. Also described are compositions and method of compostions containing the derivatives of the amino acids or peptides, and their uses including treating and preventing dermatological or cosmetic conditions or other disorders of the cutaneous system. Compositions and methods of using the compositions for skin lightening and cosmetics are also disclosed. | 2022-04-28 |
20220127243 | COMPOUND FOR USE IN RETINAL DISEASES - Provided is an aldehyde binder, specifically, disclosed is a compound as represented by formula (II) or a pharmaceutically acceptable salt. | 2022-04-28 |
20220127244 | POLYMORPHIC FORMS OF 3-(4-AMINO-1-OXO-1,3 DIHYDRO-ISOINDOL-2-YL)-PIPERIDINE-2,6-DIONE - Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione are disclosed. Compositions comprising the polymorphic forms, methods of making the polymorphic forms and methods of their use are also disclosed. | 2022-04-28 |
20220127245 | METHOD FOR PREPARATION OF EFINACONAZOLE IN IONIC LIQUID MEDIUM - The present invention relates to a novel method for preparing efinaconazole using an ionic liquid as a medium. The method includes subjecting 1-[[(2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiranyl]methyl]-1H-1,2,4-triazole to a coupling reaction with 4-methylenepiperidine or an organic chemically acceptable salt thereof in the presence of a base and an ionic liquid compound. The base makes the 4-methylenepiperidine or organic chemically acceptable salt thereof anionic. The use of the ionic liquid in the method of the present invention prevents the formation of related substances, shortens the reaction time, and enables easy preparation of the final compound efinaconazole in high purity and yield on a large scale, compared to the use of organic solvents in conventional methods. | 2022-04-28 |
20220127246 | BENZIMIDAZOLE DERIVATIVES AND AZA-BENZIMIDAZOLE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF - The present disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The provided compounds may be kinase (e.g., Janus kinase (JAK), e.g., Janus kinase 2 (JAK2)) inhibitors. Also provided are pharmaceutical compositions and kits including the provided compounds. Further provided are methods of using the provided compounds, pharmaceutical compositions, and kits (e.g., for treating a disease (e.g., proliferative disease) in a subject in need thereof). | 2022-04-28 |
20220127247 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE - The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders. | 2022-04-28 |
20220127248 | PREPARATION METHOD FOR MORPHOLINQUINAZOLINE COMPOUND AND MIDBODY THEREOF - The present disclosure relates to a preparation method morpholinquinazoline compound and a midbody thereof. The preparation method for morpholinquinazoline compound comprises the following steps: S1, performing a Suzuki reaction of compound S and compound IV as represented by the following formula, so as to obtain compound V; step S2, performing a reaction of methylsufonyl chloride and compound V in an organic solvent as represented by the following formula, so as to obtain compound VI; and S3, performing a coupled reaction of compound VII and compound VI in a solvent as represented by the following formula, so as to obtain compound YY-20394. The preparation method has the advantages of higher yield, better selectivity, simple operation and mild reaction condition, and is applicable to industrial production. | 2022-04-28 |
20220127249 | CRYSTALLINE FORM OF 1-(1-OXO-1,2-DIHYDROISOQUINOLIN-5-YL)-5-(TRIFLUOROMETHYL)-N-(2-(TRIFLUORO- METHYL)PYRIDIN-4-YL)-1H-PYRAZOLE-4-CARBOXAMIDE MONOHYDRATE - The present invention relates to a crystalline form of 1-(1-oxo-1,2-dihydroisoquinolin-5-yl)-5-(trifluoromethyl)-N-[2-(trifluoromethyl)pyridin-4-yl]-1H-pyrazole-4-carboxamide (Compound A) monohydrate, and processes for preparation thereof. The crystalline form and compositions thereof are useful in the treatment of MALT-1 related diseases. | 2022-04-28 |
20220127250 | LANCL LIGANDS - Provided are compounds that target the lanthionine synthetase C-like (LANCL) family of proteins, including LANCL2 and LANCL3. The compounds can be used to treat conditions such as inflammatory diseases, metabolic diseases, autoimmune diseases, cancers, and infectious diseases. Exemplary conditions include inflammatory conditions of the liver, such as nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and cirrhosis; inflammatory conditions of the bile duct, such as primary biliary cholangitis, primary sclerosing cholangitis; inflammatory bowel disease, such as Crohn's disease and ulcerative colitis; lupus, such as systemic lupus erythematosus, lupus nephritis, and cutaneous lupus; arthritis, such as rheumatoid arthritis; hyperglycemia, such as type 1 diabetes, type 2 diabetes, and prediabetes and associated conditions such as atherosclerosis and diabetic kidney disease; psoriasis; and multiple sclerosis. | 2022-04-28 |
20220127251 | PROCESS FOR THE PRODUCTION OF ARYLAMINES - The invention relates to a process for producing compounds containing at least one arylamino group by means of a palladium-catalysed coupling reaction of an arylamino compound with an aryl compound, using LiOtBu as a base. | 2022-04-28 |
20220127252 | METHODS OF SYNTHESIZING A DIFLUOROLACTAM ANALOG - The present invention relates to processes and intermediates for preparing compounds of formula (IA), wherein R | 2022-04-28 |
20220127253 | COMPOUNDS FOR PREVENTING, INHIBITING, OR TREATING CANCER, AIDS AND/OR PREMATURE AGING - The manufacture and use of compounds of formula (Ia) or a pharmaceutically acceptable salt thereof for preventing, inhibiting or treating cancer, AIDS and/or premature aging. The compounds of formula (Ia) being: | 2022-04-28 |
20220127254 | INDAZOLYL-ISOXAZOLE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER - Compounds of the formula I | 2022-04-28 |
20220127255 | HERBICIDAL COMPOUNDS - The present invention relates to herbicidally active pyridazine derivatives of Formula (I) as defined herein, as well as to herbicidal compositions comprising such derivatives, and the use of such compounds and compositions for controlling undesirable plant growth: in particular the use for controlling weeds, in crops of useful plants. | 2022-04-28 |
20220127256 | COMPOUNDS AND METHODS OF USE - Compounds are provided according to Formula (I): | 2022-04-28 |
20220127257 | SMALL MOLECULES - Compounds having the general structure A-L-B are presented wherein A and B are independently an E3 ubiquitin ligase protein binding ligand compound of formula 1A or 1B. Pharmaceutical compositions comprising these compounds and methods of use are also presented. | 2022-04-28 |
20220127258 | AROMATIC RING OR HETEROAROMATIC RING COMPOUNDS, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF - The present invention relates to aromatic ring or heteroaromatic ring compounds, a preparation method therefor and a medical use thereof. Particularly, the present invention relates to a compound as shown in general formula (I) and a preparation method therefor, a pharmaceutical composition comprising the compound and a use thereof as an agonist for a farnesoid X receptor (FXR). The compound and the pharmaceutical composition comprising the compound can be used for treating and/or preventing FXR activity-related diseases, for example, cholestatic symptoms, diabetes and complications thereof, nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatosis heptitis (NASH), obesity or metabolic syndrome (diseases associated with dyslipidemia, diabetes, abnormally high body weight index), cardiovascular diseases and so on. The definition of each substituent in the general formula (I) is the same as that in the description. | 2022-04-28 |
20220127259 | SOLID STATE FORMS OF VALBENAZINE - Solid state forms of Valbenazine, Valbenazine salts, processes for preparation thereof and pharmaceutical compositions thereof are disclosed. Processes for the preparation of Valbenazine and intermediates in the preparation thereof are further described. | 2022-04-28 |
20220127260 | IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF - The present disclosure provides compounds of Formula (I′) (e.g., compounds of Formula (I)), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, cocrystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The provided compounds may be kinase (e.g., Janus kinase (JAK), e.g., Janus kinase 2 (JAK2)) inhibitors. Also provided are pharmaceutical compositions and kits including the provided compounds. Further provided are methods of using the provided compounds, pharmaceutical compositions, and kits (e.g., for treating a disease (e.g., proliferative disease) in a subject in need thereof). | 2022-04-28 |
20220127261 | RING DEUTERATED GABOXADOL AND ITS USE FOR THE TREATMENT OF PSYCHIATRIC DISORDERS - Ring deuterated gaboxadol is provided. The ring deuterated gaboxadol is useful in the treatment of psychiatric disorders and is more effective than non-deuterated gaboxadol in such treatments. Deuterated gaboxadol is useful in combinations with other compounds to provide additive and synergistic effects for patient therapies. In a specific embodiment, the deuterated gaboxadol is d6-gaboxadol. | 2022-04-28 |
20220127262 | CRYSTALLINE FORM OF A CDK INHIBITOR - The invention relates to a crystalline form of 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-{[1-(methylsulfonyl) piperidin-4-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one (PF-06873600) free base (Form 1). The invention also relates to pharmaceutical compositions comprising this crystalline form and to methods of using the crystalline form and such compositions for the treatment of abnormal cell growth, such as cancer, in a mammal Formula (I): | 2022-04-28 |