19th week of 2019 patent applcation highlights part 33 |
Patent application number | Title | Published |
20190136232 | Compositions And Methods For Manipulation Of Adipocyte Energy Consumption Regulatory Pathway - Provided herein is a pathway for adipocyte energy consumption regulation involving ARID5B, genetic variant rs1421085, IRX3, and IRX5. Compositions and methods for modulating the pathway in vitro and in vivo for anti-cachectic and anti-obesity effects are provided. Methods of identifying subjects at risk of developing a disorder mediated by a dysregulation of the energy consumption pathway are also provided. | 2019-05-09 |
20190136233 | MODULATING APOLIPOPROTEIN (A) EXPRESSION - Provided herein are oligomeric compounds with conjugate groups targeting apoplipoprotein (a) [apo(a)]. In certain embodiments, the apo(a) targeting oligomeric compounds are conjugated to N-Acetylgalactosamine. Also disclosed herein are conjugated oligomeric compounds targeting apo(a) for use in decreasing apo(a) to treat, prevent, or ameliorate diseases, disorders or conditions related to apo(a) and/or Lp(a). Certain diseases, disorders or conditions related to apo(a) and/or Lp(a) include inflammatory, cardiovascular and/or metabolic diseases, disorders or conditions. The conjugated oligomeric compounds disclosed herein can be used to treat such diseases, disorders or conditions in an individual in need thereof. | 2019-05-09 |
20190136234 | OLIGOMER-CONJUGATE COMPLEXES AND THEIR USE - Oligonucleotides, chemically-modified oligonucleotides, and oligonucleotide-conjugate complexes for use in research, diagnostics, and/or therapeutics are described herein. In some embodiments, oligonucleotides comprising a stabilized phosphate moiety covalently attached to the 5′-terminal nucleoside are provided. | 2019-05-09 |
20190136235 | MODIFIED U6 PROMOTER SYSTEM FOR TISSUE SPECIFIC EXPRESSION - The present invention relates to a tissue-specific promoter system for expressing microRNA (miRNA) for RNA interference-based methods of gene therapy. In these systems, the miRNA will inhibit gene expression or replace natural miRNA expression using microRNA. | 2019-05-09 |
20190136236 | The LNCRNA MEG3 for Therapy and Diagnosis of Cardiac Remodelling - The present invention relates to a compound inhibiting the expression and/or the activity of maternally expressed 3 (Meg3) for use in treating or preventing cardiac remodelling. | 2019-05-09 |
20190136237 | METHODS OF TREATING DIABETES AND/OR PROMOTING SURVIVAL OF PANCREATIC ISLETS AFTER TRANSPLANTATION - Disclosed herein are methods for treating/and or preventing diabetes using a specific inhibitor of SMAD7 expression or function. Also disclosed are methods of promoting organ and/or cell, e.g., pancreatic islet cell, survival after transplantation using a specific inhibitor of SMAD7 expression or function. | 2019-05-09 |
20190136238 | TARGETING THE GLUTAMINE TO PYRUVATE PATHWAY FOR TREATMENT OF ONCOGENIC KRAS-ASSOCIATED CANCER - Methods and kits for GPP-targeting, e.g., for the treatment of oncogenic Kras-associated cancers, and methods for determining the efficacy of those methods are provided. | 2019-05-09 |
20190136239 | GLYPICAN-3 SPECIFIC APTAMER AND USE THEREOF - The present invention relates to a DNA aptamer specifically binding to a hepatocellular carcinoma-related Glypican-3(GPC3) protein, treatment of cancers related to the Glypican-3 protein using the same, a composition for inhibiting a cancer and a composition for diagnosing a cancer comprising the same as an active ingredient. | 2019-05-09 |
20190136240 | NUCLEIC ACID APTAMERS - Disclosed herein are compositions including an aptamer bound to a complex, wherein the complex comprises at least two polypeptides. Accordingly, methods of using the aptamers and making the aptamers are also disclosed. | 2019-05-09 |
20190136241 | APTAMER-BASED ANALYTE ASSAYS - The present invention relates to aptamer-based assays to capture and/or detect analytes comprising primary and secondary aptamers, as well as compositions comprising such primary and secondary aptamers, wherein analytes comprise small molecules that offer limited mutually non-competitive epitopes to antibodies, that is, with limited ability to measure in non-competitive sandwich assays using primary and secondary antibodies or primary and secondary aptamers. | 2019-05-09 |
20190136242 | PAN-GENOTYPIC AGENTS AGAINST INFLUENZA VIRUS AND METHODS OF USING THE SAME - Methods of inhibiting influenza A virus in a sample are provided. Aspects of the methods include contacting a sample comprising viral RNA (vRNA) having a PSL2 motif with an effective amount of an agent that specifically binds the PSL2 motif to inhibit the influenza A virus. Also provided are methods of treating or preventing influenza A virus infection in a subject. Also provided are methods for screening a candidate agent for the ability to inhibit influenza A virus in a cell, the method comprising: contacting a sample with a candidate agent; and determining whether the candidate agent specifically binds to the PSL2 motif of vRNA. Also provided are compounds and pharmaceutical compositions comprising an oligonucleotide sequence complementary to a PB2 vRNA region that find use in the subject methods. | 2019-05-09 |
20190136243 | METHOD FOR PREVENTING OR TREATING OBESITY BY USING A COMPOSITION INCLUDING HOGA1-INHIBITING SUBSTANCE AND METHOD OF SCREENING A PREVENTIVE OR THERAPEUTIC AGENT FOR OBESITY BY USING THE COMPOSITION - Provided are a method for preventing or treating obesity by using a composition including an inhibitor of expression of the Hoga1 gene or an inhibitor of activity of the Hoga1 protein as an active ingredient, and a method of screening a preventive or therapeutic agent for obesity by using the composition. | 2019-05-09 |
20190136244 | PHAGE-MEDIATED MANIPULATION OF WOLBACHIA - The invention relates to systems, methods, and compositions for the genetic modification of | 2019-05-09 |
20190136245 | Restorer Plants - Hybrid cereals are described which are obtained by restoring the pollen fertility for the Pampa cytoplasmic male sterility (P-CMS) and which are characterized by a reduced linkage drag. Plants are provided, in particular rye, which, as the male pollen parent, are capable of restoring the pollen fertility for the P-CMS. Furthermore, the nucleic acid molecule which carries the necessary information for restoring the P-CMS, DNA and vectors which contain such a nucleic acid molecule, corresponding host cells as well as a protein which can be encoded by the nucleic acid molecule and antibodies directed against it are also described. Furthermore, methods for the production of corresponding hybrid plants and transgenic plants are provided. | 2019-05-09 |
20190136246 | PLANT-PRODUCED CHIMAERIC ORBIVIRUS VLPS - This invention relates to a second generation, plant-produced synthetic Orbivirus candidate vaccine. The vaccine comprises a plant produced chimaeric Orbivirus virus like particle (VLP) comprising at least one structural protein from one Orbivirus serotype and at least one structural protein selected from another serotype of the Orbivirus, wherein both structural capsid proteins are from the same Orbivirus species. In particular the invention relates to a vaccine against an Orbivirus, a method of producing chimaeric Orbivirus virus-like particles (VLPs) for use in a method of prevention and/or treatment of an Orbivirus infection, the use of the chimaeric Orbivirus VLPs in the manufacture of a vaccine for an Orbivirus, and a method of preventing and/or treating an Orbivirus infection. | 2019-05-09 |
20190136247 | FLOWERING TIME-REGULATING GENES AND RELATED CONSTRUCTS AND APPLICATIONS THEREOF - Isolated polynucleotides and polypeptides, and recombinant DNA constructs useful for regulating plant heading date or flowering time are provided. Compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs are also provided. The recombinant DNA constructs comprise a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotides encode flowering time-regulating polypeptides. | 2019-05-09 |
20190136248 | NOVEL GUIDE RNA/CAS ENDONUCLEASE SYSTEMS - Compositions and methods are provided for novel guide RNA/Cas endonuclease systems. Type II Cas9 endonuclease systems originating from | 2019-05-09 |
20190136249 | ORGANELLE GENOME MODIFICATION USING POLYNUCLEOTIDE GUIDED ENDONUCLEASE - Provided herein are methods and systems for altering the genome of an organelle. In some embodiments, the method comprises introducing into an organelle a recombinant DNA construct comprising a first polynucleotide encoding at least one guide RNA and a second polynucleotide encoding a polynucleotide guided polypeptide; and growing a cell comprising the organelle under conditions in which the first polynucleotide and the second polynucleotide are each expressed. | 2019-05-09 |
20190136250 | SIMULTANEOUS GENE EDITING AND HAPLOID INDUCTION - The presently disclosed subject matter relates to using a haploid inducing line (whether existing or created) and transforming the haploid line so that it encodes cellular machinery capable of editing genes. The transformed haploid inducing line is used as a parent in a cross between two plants. During pollination, the parental gametes fuse to form an embryo; and the gene editing machinery is also delivered to the embryo at this time. During embryonic development, one set of parental chromosomes are lost, and the gene editing machinery operates on the remaining set of chromosomes. Thus, at least one haploid progeny with edited genes is produced from the cross. | 2019-05-09 |
20190136251 | GENE IMPACTING CELLULOSE CONTENT AND BIOMASS FORMATION AND METHODS OF USE - The invention relates to expression of the PdHB3 gene and uses thereof. The invention provides genetically engineered plants expressing the PdHB3 gene and inhibitors of PdHB3. The invention further provides a method for biofuel production using plant genetically engineered for expressing the PdHB3 gene. The invention further provides a method for increasing glucose and/or xylose release in a plant or plant cell. | 2019-05-09 |
20190136252 | USE OF THE SOYBEAN SUCROSE SYNTHASE PROMOTER TO INCREASE PLANT SEED LIPID CONTENT - Recombinant DNA constructs comprising the soybean sucrose synthase promoter operably linked to polynucleotides encoding transcription factors such as ODP1, Lec1 and FUSCA3 are disclosed. These constructs are used for increasing oil content while maintaining normal germination in oilseed plants. Methods to increase oil content in the seeds of an oilseed plant using this construct are also disclosed herein. | 2019-05-09 |
20190136253 | Application of IPS1 Gene in Improving Photosynthesis of Rice - A method for improving photosynthesis of rice includes the step of knocking out IPS1 gene in rice. The IPS1 gene has a nucleotide sequence shown in SEQ ID NO: 1. | 2019-05-09 |
20190136254 | ALS Inhibitor Herbicide Tolerant Mutant Plants - The present invention relates to an ALS inhibitor herbicide tolerant polyploid plants, such as | 2019-05-09 |
20190136255 | PLANTS SHOWING A REDUCED WOUND-INDUCED SURFACE DISCOLORATION - The present invention relates a plant which may comprise a modified F5H gene homolog, wherein said gene homolog may comprise a modification as compared to its corresponding wild type F5H gene homolog, wherein the presence of the modified F5H gene homolog in the plant leads to a reduction of wound-induced surface discoloration in comparison to a plant not comprising the modified F5H gene homolog. The invention also relates to a modified F5H gene homolog that leads to the reduced wound-induced surface discoloration. The invention further relates to use of the gene in breeding and producing plants that show reduced wound-induced surface discoloration. | 2019-05-09 |
20190136256 | METHODS OF CONTROLLING VEGETATIVE GROWTH AND FLOWERING TIMES BY MODULATING PHOSPHOENOLPYRUVATE SHUNT BETWEEN SHIKIMATE AND GLYCOLYSIS PATHWAYS - Disclosed herein are methods of producing plants with preferred levels of vegetative growth periods, flowering times, and resistance to stress and pathogens; and uses of such plants. The inventors have identified that the ANGUSTIFOLIA(AtAN)/CtBP gene is a major determinant of the carbon allocation between the Shikimate Pathway and the Salicylic Acid (SA) and Jasmonic Acid(JA)/Ethylene pathway. Plants with modulated growth periods, flowering times, and resistance to stress/pathogen characteristics, based on modulation of the expression or activity of the ANGUSTIFOLIA (ATAN)/CTBP gene, have divergent uses including pulp and paper production, bioproduct production, and as pathogen-resistant crops. | 2019-05-09 |
20190136257 | GENE FOR IMPROVING PLANT DISEASE RESISTANCE AND USE THEREOF - The ReXEG1 gene for improving plant disease resistance has a nucleotide sequence as shown in SEQ ID NO. 1, and encodes a product having an amino acid sequence as shown in SEQ ID NO. 3. It has a key role in resistance of tobacco to | 2019-05-09 |
20190136258 | INSECTICIDAL PROTEINS AND METHODS FOR THEIR USE - Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity. | 2019-05-09 |
20190136259 | METHODS OF USING CYT1A MUTANTS AGAINST COLEOPTERAN PESTS - The disclosure provides nucleic acids, and variants of | 2019-05-09 |
20190136260 | PROCESS FOR TRANSFECTING PLANTS - A process of transfecting a plant, comprising spraying parts of said plant with an aqueous suspension containing cells of an | 2019-05-09 |
20190136261 | GENETIC MODIFICATION OF CYTOKINE INDUCIBLE SH2-CONTAINING PROTEIN (CISH) GENE - The present disclosure is in the field of genome engineering, particularly targeted genetic modification of a CISH gene. | 2019-05-09 |
20190136262 | A Lentivirus Packaging System Comprising a Synthetic Positive Feedback Loop - Novel lentivirus packaging systems engineered with a synthetic gene network having a positive feedback loop to amplify the expression of virus genes are provided. When co-transfected into a host cell with a transfer plasmid and envelope vector, extremely high viral titers are achieved when compared to transfection of a host cell with conventional third generation packaging systems. Methods for enhancing production of lentivirus, compositions comprising high titer lentivirus, and therapeutic methods based on delivery of lentiviral nucleic acid to target cells are also provided. | 2019-05-09 |
20190136263 | ALLELE EDITING AND APPLICATIONS THEREOF - The invention relates to a method to determine a homology directed repair (HDR) event within a eukaryotic cell, wherein the cell expresses a first isoform of a surface protein, which is different from a second isoform of said surface protein with regard to an amino acid marker. The method comprises the steps of inducing a DNA double strand break, providing a HDR template DNA construct comprising the amino acid marker corresponding to the second isoform of the surface protein and subsequently determining the expression of the first or second isoform of said surface protein on said cell, wherein expression of the second isoform indicates a successful HDR event. The invention also relates to a method for editing a genomic location of interest within a eukaryotic cell, and to a method of selectively depleting or enriching an edited cell in a composition of non-edited and edited cells. | 2019-05-09 |
20190136264 | Particles Coated With Catalysts Useful for Splicing Nucleic Acids - This disclosure relates to compositions comprising particles conjugated to one or more catalytically cleaving nucleic acids and optionally an RNA ligating enzyme. In certain embodiments, particles reported herein are used for splicing nucleic acid sequences. | 2019-05-09 |
20190136265 | OPTIMAL SOYBEAN LOCI - As disclosed herein, optimal native genomic loci have been identified in dicot plants, such as soybean plants, that represent best sites for targeted insertion of exogenous sequences. | 2019-05-09 |
20190136266 | Yeast Host Cells and Methods for Producing Fatty Alcohols - The present invention provides for a genetically modified yeast cell comprising at least six or more of the following modifications: increased expression of Mus musculus fatty acid reductase, acetyl-CoA carboxylase, fatty acid synthase 1, fatty acid synthase 2, a mutant of the bottleneck enzyme encoded by ACC1 insensitive to post-transcriptional and post-translational repression, and/or a desaturase encoded by OLE1, and reduced expression of DGA1, HFD1, ADH6, and/or GDH1. The present invention provides a method for constructing the genetically modified yeast cell, and a method for producing a fatty alcohol from the genetically modified yeast cell. | 2019-05-09 |
20190136267 | APPARATUS FOR PRODUCING ORGANIC SUBSTANCE FROM WASTE AND METHOD FOR PRODUCING ORGANIC SUBSTANCE FROM WASTE - The present invention provides an apparatus and a method which are suitable for producing an organic substance using a synthesis gas from a waste gasification furnace. The apparatus | 2019-05-09 |
20190136268 | COOLING AND PROCESSING MATERIALS - Systems and methods for cooling and processing materials are disclosed. | 2019-05-09 |
20190136269 | Genetically Engineered Strain - The present disclosure discloses a genetically engineered strain, belonging to the technical field of bioengineering. L-amino acid oxidase genes, α-keto acid decarboxylase genes, alcohol dehydrogenase genes, and enzyme genes capable of reducing NAD(P) to NAD(P)H are introduced into the genetically engineered strain of the present disclosure. The present disclosure further discloses a construction method and application of a recombinant | 2019-05-09 |
20190136270 | COMPOSITIONS AND METHODS FOR THE BIOSYNTHESIS OF VANILLIN OR VANILLIN BETA-D-GLUCOSIDE - Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express a mutant AROM polypeptide and/or mutant catechol-O-methyltransferase polypeptide alone or in combination with one or more vanillin biosynthetic enzymes or UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce vanillin or vanillin beta-D-glucoside. | 2019-05-09 |
20190136271 | COMPOSITIONS AND METHODS FOR MICROBIAL CO-CULTURE - Provided herein are compositions and method for producing γ-polyglutamic acid (PGA). In particular, provided herein are bacterial co-culture systems and methods for producing PGA. | 2019-05-09 |
20190136272 | SEMI-BIOSYNTHETIC PRODUCTION OF FATTY ALCOHOLS AND FATTY ALDEHYDES - The present application relates to methods of producing one or more fatty alcohols and/or one or more fatty aldehydes from one or more unsaturated lipid moieties by combining the obtainment or production of the one or more unsaturated lipid moieties from a biological source with conversion by non-biological means of the one or more unsaturated lipid moieties to one or more fatty alcohols and/or one or more fatty aldehydes. The present application also relates to recombinant microorganisms having a biosynthesis pathway for the production of one or more unsaturated lipid moieties. The one or more fatty alcohols can further be chemically converted to one or more corresponding fatty acetates. The one or more fatty alcohols, one or more fatty aldehydes and/or one or more fatty acetates produced by the methods described herein may be one or more insect pheromones, one or more fragrances, one or more flavoring agents, or one or more polymer intermediates. | 2019-05-09 |
20190136273 | MICROBIAL OILS WITH LOWERED POUR POINTS, DIELECTRIC FLUIDS PRODUCED THEREFROM, AND RELATED METHODS - Methods and compositions for the production of dielectric fluids from lipids produced by microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a lipid pathway modification enzyme, a fatty acyl-ACP thioesterase, a desaturase, a fatty acyl-CoA/aldehyde reductase, and/or an acyl carrier protein are useful in manufacturing dielectric fluids. | 2019-05-09 |
20190136274 | MICROORGANISMS HAVING PUTRESCINE PRODUCTIVITY AND PROCESS FOR PRODUCING PUTRESCINE USING THE SAME - The present invention relates to a recombinant microorganism capable of producing putrescine, in which the microorganism is modified to have enhanced NCgl2522 activity, thereby producing putrescine in a high yield, and a method for producing putrescine using the microorganism. | 2019-05-09 |
20190136275 | SOLID FORM OF (-)-AMBROX FORMED BY A BIOCONVERSION OF HOMOFARNESOL IN THE PRESENCE OF A BIOCATALYST - A solid form of (−)-Ambrox formed by a bioconversion process. | 2019-05-09 |
20190136276 | COMPOSITION FOR PRODUCING D-PSICOSE COMPRISING D-PSICOSE 3-EPIMERASE AND SALT AND METHOD FOR PRODUCING D-PSICOSE USING SAME - The present application relates to a composition for producing D-psicose comprising (a) a D-psicose 3-epimerase, a strain expressing the enzyme or a culture of the strain, and (b) at least one salt selected from the group consisting of an aluminate and an iodate, and a method for producing D-psicose from D-fructose or a method for increasing the conversion of D-fructose into D-psicose comprising adding (b) to (a). | 2019-05-09 |
20190136277 | METHOD FOR PREPARING GLUCOSE FROM STARCH SUGAR BY USING ACIDOTHERMUS SP.-DERIVED DEBRANCHING ENZYME HAVING HEAT RESISTANCE AND ACID RESISTANCE, AND GLUCOSE PREPARED THEREBY - The present application relates to improving the production yield of glucose to be prepared by using starch sugar as a raw material and using an | 2019-05-09 |
20190136278 | MUTANT YEAST STRAINS WITH ENHANCED PRODUCTION OF ERYTHRITOL OR ERYTHRULOSE - The invention relates to a method for enhancing the erythritol and/or erythrulose productivity and/or yield of an erythritol and/or erythrulose-producing yeast strain, such as | 2019-05-09 |
20190136279 | PROCESS FOR PRODUCING A BIO-PRODUCT - It is disclosed a process for producing a bio-product from a ligno-cellulosic biomass, wherein the ligno-cellulosic biomass, a gas and steam are introduced in a pressurized reactor operated in a continuous manner at conditions to have a vapor head space. In the pressurized reactor, the vapor head space is maintained at a vapor head space temperature and at a pressure which is at least 1 bar greater than a pure steam equilibrium pressure at the vapor head space temperature. The ligno-cellulosic biomass is then refined by rapidly releasing the pressure while discharging the ligno-cellulosic biomass from the pressurized reactor assembly to create a pre-treated ligno-cellulosic biomass, which is then hydrolyzed and converted to the bio-product. Preferably, at least a portion of the gas is air entrapped in the ligno-cellulosic biomass and it is introduced into the pressurized reactor as part of the ligno-cellulosic biomass. In a preferred embodiment, the lignocellulosic biomass is subjected to a soaking step and an aeration step prior to being introduced into the pressurized reactor, without any xylans separation step. | 2019-05-09 |
20190136280 | PROCESS FOR THE PRODUCTION OF ULTRAPURE GALACTO-OLIGOSACCHARIDES - The present invention describes a process for preparing ultrapure (≥95%) galacto-oligosaccharides (GOS), starting from GOS at lower purities by using sequential microbiological purifications involving | 2019-05-09 |
20190136281 | CONVERSION OF SUGARS TO IONIC LIQUIDS - Disclosed herein are methods for preparing sugar compositions. The methods include: i) forming a mixture including polysaccharide biomass and an ionic liquid solution, wherein the ionic liquid solution contains water and an ionic liquid, and the ionic liquid contains a) a cation and b) a sugar acid anion or a ketoacid anion; ii) maintaining the mixture under conditions sufficient to dissolve at least a portion of the polysaccharide present in the polysaccharide biomass; iii) adding at least one glycoside hydrolase to the mixture; and iv) maintaining the mixture containing the glycoside hydrolase under conditions sufficient to hydrolyze at least a portion of the dissolved polysaccharide, thereby forming the sugar compositions. The sugar compositions contain at least one monosaccharide or oligosaccharide. New sugar-based ionic liquids are also described. | 2019-05-09 |
20190136282 | 3-EPIMERASE AND POLYNUCLEOTIDE ENCODING SAME - Provided are a 3-epimerase, an encoding polynucleotide therefor, a nucleic acid construct, vector, and host cell comprising the polynucleotide, a method for producing the 3-epimerase, and use of the 3-epimerase. | 2019-05-09 |
20190136283 | MODIFICATION OF RNA-RELATED ENZYMES FOR ENHANCED PRODUCTION - The present invention provides, among other things, methods and compositions for large-scale production of capped mRNA using SUMO-Guanylyl Transferase fusion protein. | 2019-05-09 |
20190136284 | COMPOSITIONS AND METHODS FOR THE PRODUCTION OF COMPOUNDS - The present disclosure provides nucleic acids encoding a Large ATP-binding regulator of the LuxR family (LAL) of transcription factors, vectors and host cells including such nucleic acids, and methods for producing compounds (e.g., polyketides or β-lactam compounds) with such nucleic acids, vectors, and/or host cells. | 2019-05-09 |
20190136285 | FLAVIN-BINDING GLUCOSE DEHYDROGENASE VARIANT - The present invention relates to FAD-GDH consisting of the amino acid sequence of SEQ ID NO: 1 or 3, an amino acid sequence having an identity of 70% or more with the amino acid sequence of SEQ ID NO: 1 or 3, or an amino acid sequence having a deletion, substitution or addition of one or several amino acids in the amino acid sequence (the amino acid sequence of SEQ ID NO: 1 or the amino acid sequence having an identity of 70% or more with the amino acid sequence of SEQ ID NO: 1); having an amino acid substitution at the position(s) corresponding to the following amino acid(s): the amino acid at the 175th position in the amino acid sequence of SEQ ID NO: 1, the amino acid at the 214th position in the amino acid sequence of SEQ ID NO: 1, the amino acid at the 192nd position in the amino acid sequence of SEQ ID NO: 1, the amino acid at the 212th position in the amino acid sequence of SEQ ID NO: 1, the amino acid at the 218th position in the amino acid sequence of SEQ ID NO: 1, and/or the amino acid at the 226th position in the amino acid sequence of SEQ ID NO: 1; and having an improved thermal stability compared to that before the substitution, provided that an FAD-GDH consisting of the amino acid sequence of SEQ ID NO: 28, 30 or 32 is excluded. | 2019-05-09 |
20190136286 | DIAGNOSIS OF CONSTIPATION BY ANALYSIS OF METHANE CONCENTRATION - Disclosed are methods of diagnosing constipation and constipation-predominant irritable bowel syndrome by screening for the presence of abnormally high levels of methane and/or methanogenic organisms in a subject. | 2019-05-09 |
20190136287 | Microbial Ecology Shift Assay - The disclosure provides assay methods for characterizing the effects of an agent on a microbiome of a subject. Moreover, the disclosure provides methods for practical applications of assay results. The biological sample is extracted and the microbial population is enumerated by using signals or markers specific to the microbial species. The enumerated population is subjected to the action of one or many therapeutic agents and the efficiency is assessed by deriving a score based on the effects in the individual samples and in the population of samples. | 2019-05-09 |
20190136288 | CONTROL PROCESSES FOR MICROORGANISM-RELATED CHARACTERIZATION PROCESSES - Embodiments of a method and/or system, such as for improving a microorganism-related characterization process, can include: preparing a set of control samples (e.g., from an individual specimen); determining one or more reference microorganism-related parameters (e.g., cutoff reference ranges of relative abundance for a set of microorganism taxa) based on one or more control samples of the set of control samples; and determining one or more variability parameters for the microorganism-related characterization based on the one or more reference microorganism-related parameters and one or more control sample characterizations for one or more control samples of the set of control samples. | 2019-05-09 |
20190136289 | RAPID ANTIMICROBIAL SUSCEPTIBILITY TEST, BASED ON AN ANALYSIS OF CHANGES IN MORPHOLOGY AND GROWTH PATTERN OF A MICROBIAL CELL UNDER DIFFERENT CONCENTRATIONS OF VARIOUS ANTIMICROBIAL AGENTS, AND AUTOMATED CELL IMAGE ANALYSIS SYSTEM THEREFOR - Provided are a rapid antimicrobial susceptibility test, based on an analysis of changes in morphology and growth pattern of a microbial cell under different concentrations of various antimicrobial agents, and an automated cell image analysis system therefor. The antimicrobial susceptibility test is rapidly performed based on an analysis of changes in morphology and growth pattern of a microbial cell under different concentrations of various antimicrobial agents, and this makes it possible to obtain highly reliable test results faster by six to seven times than the standard method recommended by Clinical and Laboratory Standards Institute (CLSI). | 2019-05-09 |
20190136290 | DEVICES, SYSTEMS AND METHODS TO DETECT VIABLE INFECTIOUS AGENTS IN A FLUID SAMPLE AND SUSCEPTIBILITY OF INFECTIOUS AGENTS TO ANTI-INFECTIVES - Various devices, systems and methods for detecting infectious agents or determining a susceptibility of an infectious agent to an anti-infective are described herein. One example method comprises introducing a fluid sample to a surface; exposing the surface to a solution; sampling the solution after exposing the solution to the surface; and detecting a change in an electrical characteristic of a sensing device exposed to the solution sampled corresponding to a presence of the infectious agent in the fluid sample. | 2019-05-09 |
20190136291 | Microorganism Detection Method Comprising at Least One Alkyl(thio)glycoside - A microorganism detection medium, said detection being based on showing the presence of a microbial enzyme activity chosen from esterase and/or osidase and/or peptidase and/or sulfatase and/or phosphatase activities of microorganisms, preferably said microbial enzyme activity being an esterase activity, said medium comprising:
| 2019-05-09 |
20190136292 | Universal Calibration Method for Assaying Enzymatic Inhibitors - The present invention relates to a universal calibration method of use for assaying inhibitors of the same enzyme, for example for assaying inhibitors of an enzyme of blood coagulation. The invention also relates to the use of this universal calibration in a method for assaying a reversible or irreversible inhibitor of the enzyme in a biological sample. The invention also relates to the use of the universal calibration in a method for screening inhibitors of the enzyme. | 2019-05-09 |
20190136293 | Compositions, Kits and Related Methods for the Detection and/or Monitoring of Salmonella - Provided are compositions, kits, and methods for the identification of | 2019-05-09 |
20190136294 | CONDITIONAL PRIMER EXTENSION FOR SINGLE-MOLECULE DETECTION - The present disclosure provides, in some embodiments, methods and compositions for single-molecule detection. | 2019-05-09 |
20190136295 | RAPID EXTRACTION OF NUCLEIC ACIDS FROM CLINICAL SAMPLES FOR DOWNSTREAM APPLICATIONS - Disclosed herein are novel methods and compositions for rapidly extracting and amplifying nucleic acids from a sample where the sample is combined with an extraction reagent comprising a reducing agent to form a mixture and incubating said mixture at ambient temperature for a period of time not exceeding 30 minutes to generate a nucleic acid extract. In certain embodiments of the method, the nucleic acid extract is subjected to a nucleic acid amplification reaction. In certain aspects, oligonucleotide primers specific for nucleic acids of | 2019-05-09 |
20190136296 | Ultra-Sensitive Platform for Nucleic acid detection using a novel method, Scanning Digital polymerase chain reaction (PCR) - A method for analyzing a target nucleic acid includes diluting nucleic acid targets and filling pico to femto-liter sized wells such that they contain a single target nucleic acid and one or more amplification reagents, amplifying the target in the individual wells, distinguishing wells containing amplicon from the target and amplicon from a variant of the target generated by polymerase error by using two differently labeled-hybridization probes, one hybridizing to the target and one hybridizing to a specific variant of the target; and analyzing target amplicons. | 2019-05-09 |
20190136297 | SYSTEMS AND METHODS FOR FLUORESCENCE DETECTION WITH A MOVABLE DETECTION MODULE - A fluorescence detection apparatus for analyzing samples located in a plurality of wells in a thermal cycler and methods of use are provided. In one embodiment, the apparatus includes a support structure attachable to the thermal cycler and a detection module movably mountable on the support structure. The detection module includes one or more channels, each having an excitation light generator and an emission light detector both disposed within the detection module. When the support structure is attached to the thermal cycler and the detection module is mounted on the support structure, the detection module is movable so as to be positioned in optical communication with different ones of the plurality of wells. The detection module is removable from the support structure to allow easy replacement. | 2019-05-09 |
20190136298 | METHOD AND SYSTEM FOR MICROBIOME-DERIVED DIAGNOSTICS AND THERAPEUTICS FOR ECZEMA - Methods, compositions, and systems are provided for detecting one or more an eczema issues by characterizing the microbiome of an individual, monitoring such effects, and/or determining, displaying, or promoting a therapy for the eczema issue. Methods, compositions, and systems are also provided for generating and comparing microbiome composition and/or functional diversity datasets. Methods, compositions, and systems are also provided for generating a characterization model and/or therapy model for eczema. | 2019-05-09 |
20190136299 | METAGENOMIC METHOD FOR IN VITRO DIAGNOSIS OF GUT DYSBIOSIS - The present invention concerns a metagenomic method for in vitro diagnosis of gut dysbiosis able to assign a dysbiosis degree in comparison to healthy subjects. | 2019-05-09 |
20190136300 | REDOX LABELED OLIGONUCLEOTIDE PROBES AND THEIR USE - This invention relates to sequence specific electrochemically-labeled oligonucleotide probes for the detection of nucleic acids and methods associated therewith. | 2019-05-09 |
20190136301 | OPTIMIZATION OF MULTIGENE ANALYSIS OF TUMOR SAMPLES - A method of analyzing a tumor sample comprising:
| 2019-05-09 |
20190136302 | METHODS FOR DETECTING OLIGONUCLEOTIDES IN A SAMPLE - Certain embodiments of the invention provide a method (i.e., Enzyme Linked Oligonucleotide Sorbent Assay (ELOSA)) for the detection and/or quantification of a test oligonucleotide (e.g., a small oligonucleotide) in a test sample, such as a biological fluid, comprising: a) contacting the test sample with i) a capture reagent bound to a solid support, wherein the capture reagent comprises an oligonucleotide comprising a nucleic acid sequence complementary to the test oligonucleotide; and ii) a competition oligonucleotide operably linked to an enzyme, wherein the competition oligonucleotide comprises a nucleic acid sequence complementary to the capture oligonucleotide; thereby creating a reaction mixture; b) contacting the reaction mixture with a substrate that specifically binds to the enzyme, thereby generating an enzyme-substrate reaction product; and c) measuring the concentration of the enzyme-substrate reaction product, so as to detect and/or quantify the test oligonucleotide. | 2019-05-09 |
20190136303 | POLYNUCLEOTIDE ENRICHMENT AND AMPLIFICATION USING CRISPR-CAS OR ARGONAUTE SYSTEMS - A method for enriching or amplifying a target nucleic acid including providing a system having a guide nucleic acid, and a Cas or Argonaute protein or a variant thereof. The guide nucleic acid contains a target-specific nucleotide region substantially complementary to a region of the target nucleic acid, and contacting the target nucleic acid with the system to form a complex. | 2019-05-09 |
20190136304 | DETECTION ACCURACY IDENTIFYING METHOD, DETECTION ACCURACY IDENTIFYING DEVICE, AND NON-TRANSITORY RECORDING MEDIUM STORING DETECTION ACCURACY IDENTIFYING PROGRAM - Provided is a detection accuracy identifying method for identifying a detection accuracy for detecting a testing target nucleic acid, the method including identifying a detection accuracy ability of the testing target nucleic acid, using a standard substance containing a known number of nucleic acid molecule and based on a probability at which the known number of nucleic acid molecule is detected. | 2019-05-09 |
20190136305 | METHODS FOR NEXT GENERATION GENOME WALKING AND RELATED COMPOSITIONS AND KITS - Methods are provided herein for identifying rare and/or unknown DNA sequences by next-generation sequencing approaches. Isolated double-stranded (ds), single-stranded (ss), or ds/ss DNA is fragmented and the fragments are polished, phosphorylated, and tailed, as necessary. Fragmentation can be enzymatic or mechanical. A universal adapter sequence is ligated to each fragment, wherein the adapter can have a top strand without a 5′ phosphate, a 3′ with an —H in place of the —OH, and/or a 3′ extra base complementary to any base added to the polished fragments. The ligatamers may then serve as templates for ampli?cation using a forward primer complementary to the adapter sequence and a reverse primer targeted to the fragment sequence. Compositions produced by these methods and kits adapted for performing these methods are also described herein. | 2019-05-09 |
20190136306 | METHODS FOR DETERMINING A NUCLEOTIDE SEQUENCE CONTIGUOUS TO A KNOWN TARGET NUCLEOTIDE SEQUENCE - The technology described herein is directed to methods of determining oligonucleotide sequences, e.g. by enriching target sequences prior to sequencing the sequences. | 2019-05-09 |
20190136307 | SYSTEMS AND METHODS FOR WRITING, READING, AND CONTROLLING DATA STORED IN A POLYMER - The disclosure provides a novel system of storing information using a charged polymer, e.g., DNA, the monomers of which correspond to a machine-readable code, e.g., a binary code, and which can be synthesized and/or read using a novel nanochip device comprising nanopores; novel methods and devices for synthesizing oligonucleotides in a nanochip format; novel methods for synthesizing DNA in the 3′ to 5′ direction using topoisomerase; novel methods and devices for reading the sequence of a charged polymer, e.g., DNA, by measuring capacitive or impedance variance, e.g., via a change in a resonant frequency response, as the polymer passes through the nanopore; and further provides compounds, compositions, methods and devices useful therein. | 2019-05-09 |
20190136308 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS - This invention provides a process for sequencing single-stranded DNA employing modified nucleotides. | 2019-05-09 |
20190136309 | Method and System of Nanopore-based Information Encoding - This invention provides methods and systems of DNA synthesis including providing an encoding unit comprising an enzyme, a single-stranded DNA (ssDNA) and a nanopore, providing a lipid bilayer having on opposite sides a cis and a trans reservoir each having a different buffer composition, wherein the nanopore is within the lipid bilayer and the enzyme and the ssDNA are in the cis reservoir, providing an electrode over the lipid bilayer wherein the electrode can modulate voltage across the lipid bilayer, wherein the enzyme catalyzes DNA synthesis in response to the voltage. | 2019-05-09 |
20190136310 | SINGLE MOLECULE SEQUENCING AND UNIQUE MOLECULAR IDENTIFIERS TO CHARACTERIZE NUCLEIC ACID SEQUENCES - Embodiments of a method and/or system (e.g., for improved single molecule sequencing, etc.) can include preparing a set of unique molecular identifier (UMI)-based molecules associated with a set of target nucleic acid sequences; facilitating generation of (e.g., generating, etc.) a set of tagged nucleic acid molecules based on the set of UMI-based molecules and a set of nucleic acid molecules corresponding to (e.g., including, etc.) the set of target nucleic acid sequences; and/or facilitating (e.g., performing, etc.) single molecule sequencing with the set of tagged nucleic acid molecules. | 2019-05-09 |
20190136311 | SYSTEMS AND METHODS FOR SELECTIVELY ADDRESSING SPARSELY ARRANGED ELECTRONIC MEASUREMENT DEVICES - A circuit comprising a substrate with sectors on the substrate is provided, each sector comprising clock and data lines, a controller in electrical communication with the clock and data lines, a counter bias line, an amplifier input line and nano-electronic measurement devices on the substrate. A source of each device is coupled to the counter bias line and a drain of each device is coupled to the amplifier input line to obtain an electrical signal on the drain, the identity of which is determined by electrical interaction between the device and a charge label. Each device drain is gated by a corresponding switch between an on state, in which the drain is connected to the amplifier input line, and an off state, in which the drain is isolated from the amplifier input line. The controller controls switch states responsive to clock signal line pulses and data input line data. | 2019-05-09 |
20190136312 | Parallel Polymer Sequencing Methods - The present invention relates to a method of sequencing a target polynucleotide by enzymatic and/or chemical means. The sequencing method includes a method for characterizing multiple alleles in a sample, a method for comparing polynucleotide sequence. The method involves analysing molecules as members of an array. Many target polynucleotides or many segments of a single target polynucleotide can be sequenced simultaneously. In a preferred embodiment the method involves analysing individual molecules within an array and base calls are based on the signals from two or more molecules. A method to prevent non-specific signal in sequencing is also provided. The invention is readily automated, both for small-scale and large-scale operation and relevant algorithms and the composition of kits and systems are provided. | 2019-05-09 |
20190136313 | LOADING EXTENDED POLYMERASE-NUCLEIC ACID COMPLEXES - Compositions, methods and systems are provided for the loading of extended polymerase-nucleic acid complexes onto substrates. Primed polymerase-template complex comprising a polymerase enzyme and a circular nucleic acid template comprising a double stranded region connected at each end by a single-stranded hairpin region are provides in which the circular nucleic acid template comprises at least one reversible pause point. Nucleic acid synthesis is carried out such that a nascent strand is synthesized up to the reversible stop point producing an extended polymerase-template complex. The extended polymerase-template complex is then attached to a substrate. Such attached complexes can be used for single molecule sequencing in which the nucleic acid synthesis is re-initiated such that nucleic acid synthesis continues past the reversible stop point. | 2019-05-09 |
20190136314 | COLORECTAL CANCER ASSOCIATED CIRCULATING NUCLEIC ACID BIOMARKERS - The invention provides methods and reagents for diagnosing colorectal cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated. | 2019-05-09 |
20190136315 | HIGH DATA RATE INTEGRATED CIRCUIT WITH POWER MANAGEMENT - A sensor device includes a sensor array and a flow cell in fluid communication with the sensor array. Bias circuitry apply bias arrangements to the sensor array to produce sensor data. Peripheral circuitry coupled to the bias circuitry produces streams of data from the sensor array, the peripheral circuitry having an active mode and an idle mode. Logic to switch the peripheral circuitry between the active mode and the idle mode to control power consumption is provided. A temperature sensor may be included, and the logic can operate with feedback to switch between the active mode and the idle mode to maintain the temperature within an operating range. | 2019-05-09 |
20190136316 | METHODS AND SYSTEMS FOR PROCESSING POLYNUCLEOTIDES - The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing. | 2019-05-09 |
20190136317 | METHODS AND SYSTEMS FOR PROCESSING POLYNUCLEOTIDES - The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing. | 2019-05-09 |
20190136318 | METHODS FOR PREDICTING ANTI-CANCER RESPONSE - The present invention is based, in part, on the identification of novel methods for defining predictive biomarkers of response to anti-cancer drugs. | 2019-05-09 |
20190136319 | METHODS AND SYSTEMS FOR PROCESSING POLYNUCLEOTIDES - The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing. | 2019-05-09 |
20190136320 | MICRORNA BIOMARKERS IN BLOOD FOR DIAGNOSIS OF ALZHEIMER'S DISEASE - The present invention relates to panels of biomarker microRNAs for use in methods of diagnosing Alzheimer's disease and related diseases and conditions in a subject. The methods involve assessing the level of said biomarker microRNA(s) in subject blood sample. The invention also relates to kits comprising said panels of biomarker microRNAs, methods of diagnosing Alzheimer's disease and to the use of said panels of biomarker microRNAs in diagnosis. | 2019-05-09 |
20190136321 | USE OF TRANSLATIONAL PROFILING TO IDENTIFY TARGET MOLECULES FOR THERAPEUTIC TREATMENT - The present invention provides methods of identifying an agent or drug candidate molecule, validating a target, and identifying normalizing therapeutics that modulates translation, such as in an oncogenic signaling pathway, in a biological sample as determined by translational profiling of one or more genes in the biological sample. The present invention also provides diagnostic and therapeutic methods using the translational profiling methods described herein. | 2019-05-09 |
20190136322 | Method of Predicting Risk for Type 1 Diabetes - The present invention relates to methods, transcriptome profiles and kits useful for determining, before seroconversion, the risk that an individual will develop Type 1 diabetes (T1D). | 2019-05-09 |
20190136323 | DETERMINING A NUCLEIC ACID SEQUENCE IMBALANCE USING MULTIPLE MARKERS - Methods, systems, and apparatus are provided for determining whether a nucleic acid sequence imbalance exists within a biological sample. One or more cutoff values for determining an imbalance of, for example, the ratio of the two sequences (or sets of sequences) are chosen. The cutoff value may be determined based at least in part on the percentage of fetal DNA in a sample, such as maternal plasma, containing a background of maternal nucleic acid sequences. The percentage of fetal DNA can be calculated from the same or different data used to determine the cutoff value, and can use a locus where the mother is homozygous and the fetus is heterozygous. The cutoff value may be determined using many different types of methods, such as sequential probability ratio testing (SPRT). | 2019-05-09 |
20190136324 | METHODS FOR PREDICTING ACUTE SEVERE COLITIS TREATMENT RESPONSE - The present invention relates to methods for predicting acute severe colitis treatment response. Currently, there is no biomarker of drug response. The present invention provides the first prediction tool for responses to first- and second-line treatments in acute severe ulcerative colitis. Putative mRNA targets of dysregulated microRNAs were identified from patient biopsies. One classifier of fifteen colonic microRNAs plus five biological values at admission were identified with a prediction accuracy of 96.6% for discriminating responders from non-responders to steroids. Using a similar method, 6 and 4 mucosal microRNA-based algorithms were identified to classify responders from non-responders to infliximab and cyclosporine. In particular, the present invention relates to methods for predicting acute severe colitis treatment response by measuring the expression levels of several miRNAs selected from the group consisting of hp_hsa-mir-3934, hp_hsa-mir-100, hsa-miR-718, hp_hsa-mir-193b, hsa-miR-3150a-5p, hp_hsa-mir-1260b, hsa-miR-938, hsa-miR-518b and hsa-miR-1468. | 2019-05-09 |
20190136325 | METHODS AND COMPOSITIONS FOR DETECTING ESOPHAGEAL NEOPLASIAS AND/OR METAPLASIAS IN THE ESOPHAGUS - The disclosure provides methods for identifying genomic loci that are differentially/methylated in neoplastic cancers, e.g., esophageal cancers. Identification of methylated genomic loci, and optionally in combination with the identification of somatic mutations in TP53, has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal neoplasias. | 2019-05-09 |
20190136326 | MOLECULAR PROGNOSTIC SIGNATURE FOR PREDICTING BREAST CANCER METASTASIS, AND USES THEREOF - The present invention is based on the discovery of a unique 14-gene molecular prognostic signature that is useful for predicting breast cancer metastasis. In particular, the present invention relates to methods and reagents for detecting and profiling the expression levels of these genes, and methods of using the expression level information in predicting risk of breast cancer metastasis. | 2019-05-09 |
20190136327 | LEUKEMIA METHYLATION MARKERS AND USES THEREOF - Disclosed herein are methods and kits for identifying a subject as having leukemia. Also provided herein are methods and kits for determining a leukemia subtype in subject. Further provided herein are methods and kits for determining the prognosis of a subject having leukemia and for determining the progression of leukemia in a subject. | 2019-05-09 |
20190136328 | MARKER GENES FOR COLORECTAL CANCER CLASSIFICATION, METHOD FOR JUDGING LYMPH NODE METASTASIS FOR PROGNOSIS OF COLORECTAL CANCER AND KIT THEREFOR - A group of molecular biomarkers having the genes SLC35D3, POSTN, KLK6 and MUC2 can be used in objective and quantitative methods for the classification, prediction of prognosis and for guiding treatment decisions of a subject with colorectal cancer. More specifically, a method for determining the metastatic potential and/or tumor aggressiveness of a colorectal cancer in a subject can include determining the gene expression levels of genes SLC35D3, POSTN, KLK6 and/or MUC2 in a regional lymph node, a primary intestinal tumor, blood, or feces sample obtained from the subject. | 2019-05-09 |
20190136329 | METHODS OF DETECTING TUMOR CELLS - In one aspect, methods of detecting tumor cells are described herein. In some embodiments, a method of detecting tumor cells comprises providing a device, the device comprising a substrate surface and a plurality of first aptamer probes attached to the substrate surface. The method further comprises contacting a plurality of cells with the plurality of first aptamer probes attached to the substrate surface; adhering one or more of the plurality of cells to the substrate surface; and measuring a non-uniformity parameter, a Hausdorff distance, a change in the number of pseudopods, and/or a shape of at least one adhered cell. In some cases, the method further comprises using the non-uniformity parameter, Hausdorff distance, change in the number of pseudopods, and/or shape of the adhered cell to identify the adhered cell as a tumor cell or a non-tumor cell. | 2019-05-09 |
20190136330 | METHOD FOR SCREENING CANCER - Disclosed in the present invention is a method for screening cancer, comprising the following steps: (1) providing a specimen to be detected; (2) detecting the methylation status of CpG sequence of at least one target gene which is at least one of ADRA1D, AJAP1, HS3ST2, MAGI2, POU4F2, POU4F3, PTGDR, SOX17 and SYT9 in genomic DNA of the specimen; (3) determining whether cancer or precancerous lesions are present in the specimen according to the methylation status of at least one target gene. | 2019-05-09 |
20190136331 | MAIZE EVENT DP-004114-3 AND METHODS FOR DETECTION THEREOF - The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DP-004114-3 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided. | 2019-05-09 |