19th week of 2010 patent applcation highlights part 44 |
Patent application number | Title | Published |
20100119982 | ETCHING METHOD AND MANUFACTURING METHOD OF SEMICONDUCTOR DEVICE - An etching method according to an embodiment includes forming a resist film on a workpiece film, exposing the resist film, developing the resist film so as to form a resist pattern, selectively irradiating a particular place of the resist pattern with an energy beam so as to generate an acid component in the particular place of the resist pattern, forming a film including a cross-linking agent that causes a cross-linking reaction due to the acid component on the workpiece film so as to cover the particular place of the resist pattern where the acid component is generated, reacting the cross-linking agent with the resist pattern so as to form a cross-linked layer in a part of the resist pattern and processing the workpiece film by using the resist pattern and the cross-linked layer as a mask. | 2010-05-13 |
20100119983 | Regenerator burner - In a high efficiency regenerator burner for heating spaces, the exhaust gas generated by the burner is provided which is conducted alternately through different regenerator cartridges and a partial stream of the exhaust gas is conducted under the control of an orifice plate through a bypass space in which the regenerator cartridges are disposed. A control structure is disposed in a burner head for controlling the exhaust gas bypass flow volume and also to control the main exhaust gas flow as well as the combustion air flow through the regenerator cartridges. | 2010-05-13 |
20100119984 | ABATEMENT SYSTEM - Abatement systems are described. An abatement system includes a combustion chamber and a fuel burner ring coupled with the combustion chamber. Another abatement system includes a combustion chamber and a fuel flow control mechanism coupled with the combustion chamber. | 2010-05-13 |
20100119985 | CURING OVEN - A curing oven, particularly for curing a continuous mat of mineral wool fibres mixed with binder has an air injecting system for injecting ambient air into at least one heating zone in circumstances in which there is a risk of inadequate ventilation. | 2010-05-13 |
20100119986 | MULTIPLE HEARTH FURNACE - A multiple hearth furnace includes a gas cooling system for its central shaft and its rabble arms. This gas cooling system includes within the shaft an annular main distribution channel for supplying a cooling gas to the rabble arms and a central exhaust channel for evacuating the cooling gas leaving the rabble arms. The gas cooling system further includes an annular main supply channel surrounding the annular main distribution channel and being outwardly delimited by an outer shell of the shaft. A cooling gas inlet is connected to the annular main supply channel. A cooling gas passage between the annular main supply channel and the annular main distribution channel is spaced from the cooling gas inlet, so that cooling gas supplied to the cooling gas inlet has to flow through the annular main supply channel through several hearth chambers before it flows through the cooling gas passage into the annular main distribution channel. | 2010-05-13 |
20100119987 | Method of Treating Residual Caries - The present invention is a method of treating residual caries utilizing a matched laser and dye combination. After initial preparation and excavation of a caries site, a dye is flooded into the site which stains areas of residual caries. A laser with a complimentary wavelength is then used to ablate stained areas. Since healthy dental tissue will not receive the dye and allow staining, diseased tissue will be the only tissue that is stained, not only providing a visual indicator, but also providing a more efficient surface to receive laser energy and allow for more efficient ablation of the compromised tissue. According to the method, the dye may contain and enhancing, oxidizing compound or an anesthetic, and surrounding tissues may be protected by the use of substances opaque to the radiant energy. Indocyanine green has shown particular effectiveness as a dye in this and related methods. | 2010-05-13 |
20100119988 | DENTAL IMPRESSION FILM, AND A METHOD OF MANUFACTURING THE DENTAL IMPRESSION FILM - Attention has been focused on combining two types of dental impression materials of different qualities which has not been considered in conventional combined impression, and a dental impression film and a method of manufacturing the dental impression film are provided for making the two parts joinable. The dental impression film is formed of a polyethylene film and polyethylene/polyester films. The polyethylene film has, laminated by thermal adhesion on opposite surfaces thereof, respectively, the polyethylene/polyester films having bonding capability between a silicone impression material and an alginate impression material. The dental impression film having bonding capability is interposed between the silicone impression material and alginate impression material. This enables joining of the silicone impression material and alginate impression material, no longer requires the timing of hardening of the impression materials to be matched, and allows a precise impression at low cost using a small amount of silicone impression material. | 2010-05-13 |
20100119989 | RETRACTING DEVICE - The present invention is related to devices utilized for retraction of the lips, tongue and oral cavity during dental procedures. In particular, the invention relates to a flexible or semi-flexible oral device used to comfortably and quickly retract the patient's lips to properly expose the patient's teeth and gums for dental procedures. | 2010-05-13 |
20100119990 | ENDODONTIC INSTRUMENT AND INSTRUMENT SYSTEM - An endodontic file for use in root canal treatment has an elongated shank having a long axis with a proximal end connected to a handle adapted to be manipulated by hand or inserted into a rotary drive. The file also includes a working portion with a plurality of continuous uninterrupted helical spiraled flutes extending to a distal end, the working portion including a plurality of alternating cutting segments and reduced diameter non-cutting segments that are spaced proximally to distally to each other along the working portion. The cutting segments may have reduced diameter non-cutting segments that have continuous uninterrupted helical flutes and associated edges interposed between the flutes. And the flutes and associated edges may pass continuously and uninterrupted between adjacent cutting segment and non-cutting segment. An individual file, or a set of files having the foregoing characteristics but with varying arrangements and/or cross sectional profiles, may be used in an endodontic procedure. | 2010-05-13 |
20100119991 | TOOTH ROOT TIP EXTRACTOR AND METHOD - An extraction device and method for extracting some or all of a tooth from a patient, such as the root of the tooth, are disclosed. One embodiment of the device includes an extraction burr having helical structure with a positive slope transition portion, and in that manner is distinguishable from a common screw. The helical structure may be configured and shaped such that there is little frictional force placed on the burr as it enters into a tooth. Once the burr enters the tooth the configuration and shape of the burr may provide for increased friction between the tooth structure and the burr, thereby causing the burr to grip the tooth structure and maintain the burr as he tooth is extracted. The extraction burr may include a partial-spiral flute or groove formed in a tip thereof. A lockable and releasable hand piece for attaching to the extraction burr provides leverage to the user for dislodging the tooth root, and is adjustable in at least three different indexable positions in its attachment position with respect to the extraction burr. | 2010-05-13 |
20100119992 | ARTIFICIAL TOOTH - The present invention provides artificial teeth of upper and lower jaws pairing between the cusp tips and pits, allowing to operate the arrangement easily by clarifying the three-dimensional positional relation of cusp tips and pits to contact with each other in occlusion and the contact region. In an artificial tooth of a mandibular first premolar tooth having a buccal cusp tip, a lingual cusp tip, a mesial pit, and a distal pit, the azimuth originating from the distal pit, the ratio of distance to the mesial surface, distal surface, buccal surface, and the lingual surface, and the positional relation of the cusp tips and pits are set appropriately. Further, in an artificial tooth of a maxillary first premolar tooth having a buccal cusp tip, a lingual cuts point, a mesial pit, and a distal pit, the azimuth originating from the lingual cusp tip, the ratio of distance to the mesial surface, distal surface, buccal surface, and the lingual surface, and the positional relation of the cusp tips and pits are set appropriately. The distal pit of the artificial tooth of the mandibular first premolar tooth is made to contact with the lingual cusp tip of the artificial tooth of the maxillary first premolar tooth, and the buccal cusp tip of the artificial tooth of the mandibular first premolar tooth is made to contact with the mesial pit of the artificial tooth of the maxillary first premolar tooth. | 2010-05-13 |
20100119993 | DENTAL IMPLANT - An oral implant for mounting in a patient's maxilla or mandible is provided that includes an abutment and a fixture. The implants may be arranged in a system including two or more adjacent implants disposed in predetermined locations and bearing a predetermined locational relationship to each other. | 2010-05-13 |
20100119994 | ARTIFICIAL DENTAL PROTHESIS, METHOD FOR THE PRODUCTION OF AN ANCHORING PART - An artificial dental prosthesis includes a crown and an implant, the implant having an abutment portion and an anchoring portion, the anchoring portion having a region for receiving the abutment portion, and wherein the anchoring portion is connected to the abutment portion forming an external contact joint. The artificial dental prosthesis is designed such that the crown covers the contact joint at least in sections. | 2010-05-13 |
20100119995 | DENTAL ABUTMENT INCLUDING FILLET - Exemplary embodiments relate to a dental abutment and methods of forming the same. The abutment ( | 2010-05-13 |
20100119996 | METHOD AND SYSTEM FOR FORMING A DENTAL PROSTHESIS - A system and method for use in constructing a prosthesis/complete restoration that obtains a digital dentition model, such as a 3D geometric surface model or a 3D volumetric image model, processes the digital dentition model to form a virtual model, forms a virtual mold including a digital prosthesis and/or complete restoration, and uses the virtual model to construct the prosthesis/complete restoration. Processing circuitry, such as a programmed server, can be used to obtain the digital dentition model and form the virtual mold. A rapid manufacturing device can be used to construct the prosthesis/complete restoration. | 2010-05-13 |
20100119997 | METHOD FOR PRODUCTION OF MESENCHYMAL CELL, METHOD FOR PRODUCTION OF TOOTH, AND MESENCHYMAL CELL FOR FORMATION OF TOOTH - The present invention provides a method for producing mesenchymal cells for production of mesenchymal cells for formation of a tooth, the method comprising: culturing totipotent stem cells in the presence of a differentiation inducer to produce a cell population after differentiation induction treatment, the cell population containing CD44-positive and CD29-positive cells or CD44-positive and CD 106-positive cells; and selecting, from the cell population after the differentiation induction treatment, the CD44-positive and CD29-positive cells or CD44-positive and CD 106-positive cells as the mesenchymal cells for the formation of the tooth. The present invention also provides a method for producing a tooth comprising: positioning, in a support carrier capable of retaining cells in a state of contacting therewith, a first cell mass substantially consisting of only either one of mesenchymal cells and epithelial cells and a second cell mass substantially consisting of only the other one of the mesenchymal cells and epithelial cells, the first and second cell masses being not mixed with each other but made to closely contact with each other; and culturing the first and second cell masses; wherein the mesenchymal cells comprise the mesenchymal cells for the formation of the tooth. | 2010-05-13 |
20100119998 | PAINT COLOR SELECTION SYSTEM AND METHOD - A self-contained paint color system and method is described comprising a handled carrying box, at least one container of a base color paint, a plurality of containers containing colored tints, and a “matchbook” styled booklet that incorporates coordinated and matching sheets and self-adhesive stickers. When utilizing this paint color selection system and method, a designer can create and select numerous colors utilizing a single kit. | 2010-05-13 |
20100119999 | Visual/Tactile teaching aid and system - A teaching system for the perception enhancement of a user provides pairs of objects for visual and tactile comparison wherein the selection of paired objects provide a significant starting point for the construction of extended teaching aides, tactile forms and systems. The present invention may be combined with a range of text associated with paired forms, and includes a range of contrasting terms and synonyms generally associated with the contrasting and complementary nature of the paired forms. | 2010-05-13 |
20100120000 | Method and Business Form for Employee Management and Improvement | 2010-05-13 |
20100120001 | EDUCATIONAL EQUIPMENT WITH MULTIPLE CONFIGURATIONS - The invention relates to educational equipment comprising a plurality of information support means ( | 2010-05-13 |
20100120002 | System And Method For Conversation Practice In Simulated Situations - Disclosed is a system and method for conversation practice in simulated situations. The system comprises situational conversation teaching material, an audio processing module and a conversation processing module. The teaching material consists of multi-flow conversation paths and conversational sentences with a plurality of replaceable vocabulary items. According to different contents of the situational conversation teaching material and biased data of the teaching material, the audio processing module dynamically adjusts speech recognition model and recognizes the inputted audio signal of the learners to determine the information on the recognition results. The conversation processing module determines the information in response to the learners, based on the information on the recognition results, the situational conversation teaching material and biased data of the teaching material. | 2010-05-13 |
20100120003 | Holistic Approach to Learning to Type - The present invention is directed to a method of teaching typing wherein the student associates the keys on the keyboard with a person, place, thing or emotion and is able to more readily learn the position of each key. Further, the method of the present invention provides immediate gratification to the student as they are able to instantly visually and auditorily appreciate the accuracy of their typing on a computer monitor or screen that is attached to the keyboard. The delete key and/or backspace key may be inactivated during operation of the program. Further, the color of the letters and background displayed on the monitor or screen may be variable. | 2010-05-13 |
20100120004 | SYMBOLTEC - Our subconscious is much smarter than our waking mind but our dreaming mind can be trained to learn a technique (Symboltec) that makes communication between the two accurate, fast and easy. A chart with symbols and a code is all that is needed to ask questions which the dreaming mind answers in its own universal language, that is pictures, which are easy to read. No interpretation is necessary, you just make a note of the picture and decode it. | 2010-05-13 |
20100120005 | SYSTEM AND METHOD FOR ENHANCING PRAYER AND HEALING RITUALS - Interactive prayer systems are provided, which include a pad that is adapted to be repeatedly stepped upon by a user; a first detection means for detecting when the user steps on the pad; a second detection means for detecting, and for creating proximity event data based upon, when the user is standing in proximity of specific areas within the pad; a communications means for communicating touch event data and proximity event data to a computer and a computer program executing on the computer; a display means connected to the computer, which displays the scripture to the user during prayer; and a notification means embedded in the pad for notifying the user when, and if, an error in the user's performance of the one or more prayer rituals is detected by the computer program. Methods of using such interactive prayer systems are also provided. | 2010-05-13 |
20100120006 | Dynamic Minimally Invasive Training and Testing Environments - The disclosed invention contemplates a device and method related to training medical personnel (i.e., for example, surgeons) to perform endoscopic procedures. The disclosed technology solves two problems currently present in the art of using surgical simulators. The first improvement provides a dynamic training program, rather than a program that is the same for every training run. In one embodiment, the device provides a target array that can change position in three dimensions during the training session. In one embodiment, the target array can also change position at various velocities. Consequently, the present invention provides improved discrimination between evaluating innate skill of hand-eye coordination versus surgical skill. | 2010-05-13 |
20100120007 | Fluid Percussion System and Method for Modeling Penetrating Brain Injury - A fluid percussion system for modeling penetrating brain injury includes a fluid percussion device that takes inputs in the form of pressurized gas and electrical signals from a computer and outputs a single hydraulic pulse, or multiple hydraulic pulses in quick succession. The fluid percussion device may include a pneumatic cylinder assembly and a hydraulic cylinder assembly that is actuated by the pneumatic cylinder assembly to produce the hydraulic pulse(s) of pressurized fluid. Each pulse may be used to rapidly inflate and deflate an attached balloon (representing a brain penetrating device). The balloon may be inserted in a test specimen, and the rapid inflation and deflation of the balloon creates a lesion that simulates a penetrating brain injury. A calibration system that employs an optical sensor may be used to determine maximum balloon diameter achieved during rapid inflation. | 2010-05-13 |
20100120008 | SYSTEM AND METHOD FOR INTERACTIVE LEARNING ON TELEVISION - A system and method for providing interactive learning applications on a television and managing the learning process is disclosed. The learning management technology utilizes internet, television, and learning management systems to allow a student to interactively access learning content. The functionality of the learning management system may be accessed on a television via a host server. The interactive application further allows parents and teachers to monitor student performance, change the learning content, control workflow, and send messages and reminders to the student. The interactive application further allows restriction of television viewing based on learning results or until an assignment has been completed. The learning content may be copied or downloaded onto a computer readable medium (e.g., a memory stick) from a central location (e.g., a Kiosk). The learning content may then be copied or uploaded to a television set-top box for execution by the television set-top box. The viewer may interact with the learning application via a remote control or other input device (e.g., a keyboard) coupled to the television set-top box. | 2010-05-13 |
20100120009 | LEARNING REINFORCEMENT SYSTEM - A learning system, method and computer program product is provided that assesses and reinforces the content of learning course. The system sends a plurality of electronic messages to a course participant at a predetermined interval where each message contains at least one of a plurality of questions entered into memory. Each message further comprises at least two possible answers associated with each of the at least one question of the plurality of questions. The system provides means to directly receive and record a participant's selected answer and can also be used to communicate additional information to a course participant. The system tracks and records a number of data points useful to determine an individual participants understanding of the course, the understanding of the participants as a whole, response rates to the electronic message sent to each participant, and the like. | 2010-05-13 |
20100120010 | Constructed response scoring mechanism - A system, method, and related techniques are disclosed for scoring user responses to constructed response test items. The system includes a scoring engine for receiving a user response to a test question and evaluating the response against a scoring rubric. The scoring rubric may include a binding stage, an assertion stage, and a scoring stage. Furthermore, the system includes a database for referencing elements used by the scoring engine which may comprise objects, object sets, attributes of objects, and transformations of any elements. | 2010-05-13 |
20100120011 | TECHNOLOGY PLATFORM AND METHODS FOR FACILITATING, CULTIVATING AND MONITORING MENTORING RELATIONSHIPS - Mentors and mentees may be matched with each other through computational matching processes. Interactions between the mentors and mentees may be structured and assisted through computational tools and interfaces. | 2010-05-13 |
20100120012 | SYSTEM FOR PROVIDING ONLINE LEARNING CONTENTS - Disclosed herein is a system for providing online learning contents, which can maximize efficiency of education based on analysis of a plurality of learning contents and matching of a result of the analysis to a student to meet characteristics and environments of the student. The system according to the present invention comprises at least two or more contents providers, an education management server, an authentication server, and a web server. Accordingly, since a student can be provided with an education corresponding to the inclination of the student, effect of online education can be enhanced. | 2010-05-13 |
20100120013 | PROCEDURE FOR LONG TERM CORNEAL CULTURE - A method for long-term multi-species cornea culture and preservation is provided. Excised mammalian corneas are preserved with structural integrity by filling the endothelial cavity with a plug material. Plugged corneas are sterile-cultured for more than 21 days via an air-interface culture where nutrients from a culture media are supplied to corneal tissue primarily through the plug. Plugged corneas are incubated in culture dishes with a customized media continuously in contact with the ocular sclera and corneal plug, and periodically bathing the corneal surface epithelia. An animal-alternative toxicology assay is also provided using excised porcine corneas capable of assessing ocular injury reversibility within 21 days. Further provided is a method of mammalian corneal preservation for excised human corneas extending their storage life to three to four weeks. | 2010-05-13 |
20100120014 | Stability Drying - A method of formulating high ambient temperature (room temperature and above) stable biologics (biologically active macromolecules, enzymes, serums, vaccines, viruses, pesticides, drug delivery systems, liposomes, cells suspensions, sperm, erythrocytes, other blood cells, stem cells, multicellular tissues, skin, heart valves) including secondary drying comprising at least two steps of stability drying at elevated temperature: 35° C., 40° C., 45° C., 50° C., and higher temperatures. The method could be applied to stabilize biologics encapsulated in alginate gel microspheres for better oral delivery. The method encompasses the following: microspheres are formulated using a cryo-encapsulation procedure comprised of mixing drops of frozen preservation mixture (To form the preservation mixture, biologics are mixed with preservation solutions containing sodium alginate.) with frozen drops of a calcium solution (i.e. calcium gluconate) and subsequent warming to form the gel particles. | 2010-05-13 |
20100120015 | METHOD OF COLLECTING PLACENTAL STEM CELLS - A method of collecting embryonic-like stem cells from a placenta which has been treated to remove residual cord blood by perfusing the drained placenta with an anticoagulant solution to flush out residual cells, collecting the residual cells and perfusion liquid from the drained placenta, and separating the embryonic-like cells from the residual cells and perfusion liquid. Exogenous cells can be propagated in the placental bioreactor and bioactive molecules collected therefrom. | 2010-05-13 |
20100120016 | METHODS AND SYSTEMS FOR DETECTION OF CONTAMINANTS - An impedance biosensor for detecting a contaminant in a starting material, the biosensor comprising a housing, an input device supported by the housing, an output device supported by the housing, a microfluidic cell supported by the housing, the starting material being engagable with the microfluidic cell, and an impedance analyzer supported by the housing and operable to measure impedance of the starting material to detect the presence of a contaminant. | 2010-05-13 |
20100120017 | RAPID IMMUNE CHROMATOGRAPHIC DETECTION BY AMPLIFICATION OF THE COLLOIDAL GOLD SIGNAL - The present invention relates to a rapid immunochromatographic test device suitable to detect more than one target in a single assay at the same time, uses of said device for detecting diseases in a sample, a method for the production of said device as well as a kit comprising the device. | 2010-05-13 |
20100120018 | Integrated Active Flux Microfluidic Devices and Methods - The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen/antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen/antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules. | 2010-05-13 |
20100120019 | Detection, screening, and diagnosis of HPV-associated cancers - Embodiments of the invention provide methods, polyclonal antibodies, monoclonal antibodies, assays, and kits for detecting HPV infection, including infection by various HPV genotypes, early and/or late HPV-associated or HPV-specific proteins or antibodies. Monoclonal antibodies are used to detect oncogenic high risk and low risk HPV types in a single assay, which is not limited to assay type or format. Useful tools for specific detection of various HPV associated cancers are provided. HPV associated cancer biomarkers are identified and can be used in a screening method for early stage precancerous lesions as well as late stage cancer progression. | 2010-05-13 |
20100120020 | FLUORESCENT NEUTRALIZATION AND ADHERENCE INHIBITION ASSAYS - The present invention comprises rugged, inexpensive, reliable, and sensitive laboratory assays of antibody-based viral neutralization activity and antibody-based viral adherence inhibition activity. The assays use inactivated, fluorescently-labeled virus, allowing the tests to be performed without extensive safety precautions. The interaction of the labeled virus with target cells is monitored using flow cytometric methods. A preferred embodiment uses simple and inexpensive flow cytometry methodologies and equipment, such as bead array readers used as simplified flow cytometers. The assays are rapid, taking no longer than a few hours and are readily conducted by a trained technician. The assays are sensitive because they use labeled viruses at low concentrations and determine neutralizing and blocking capacity of sera and antibody at low concentrations. The methods are appropriate for high-throughput screening of large panels of samples. | 2010-05-13 |
20100120021 | HPV E6, E7 MRNA Assay and Methods of Use Thereof - Provided is an HPV E6, E7 mRNA assay, referenced herein as the “In Cell HPV Assay,” that is capable of sensitive and specific detection of normal cervical cells undergoing malignant transformation as well as abnormal cervical cells with pre-malignant or malignant lesions. The In Cell HPV Assay identifies HPV E6, E7 mRNA via in situ hybridization with oligonucleotides specific for HPV E6, E7 mRNA and quantitates the HPV E6, E7 mRNA via flow cytometry. The In Cell HPV Assay can be carried out in less than three hours directly from liquid-based cervical (“LBC”) cytology specimens. The In Cell HPV Assay provides an efficient and highly sensitive alternative to the Pap smear for determining abnormal cervical cytology. | 2010-05-13 |
20100120022 | Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis - Novel splice variant nucleic acid sequences. The novel splice variants and their nucleic acid sequences according to the present invention may optionally be used for diagnosis of a variant-detectable disease as described herein. | 2010-05-13 |
20100120023 | Detection of macromolecular complexes with harmonic cantilevers - Method and apparatus which uses harmonic cantilevers, such as used in atomic force microscopy, to detect variations in the attractive and repulsive forces on a solid surface as a result of macromolecular binding, for example, hybridization of a single stranded DNA molecule attached to the surface with another DNA molecule. The complexed macromolecule is less flexible than an uncomplexed molecule. It will typically have more negative charge due to amino acids or DNA monomers. Both stiffness of the surface and the attractive capillary forces will change after binding and may be detected. By scanning the harmonic cantilever across a surface with macromolecules attached in tapping-mode and by recording the signals at the high frequency vibrations provided by harmonic cantilever, complexed molecules on a surface may be identified and quantified. | 2010-05-13 |
20100120024 | Materials and methods for the generation of transcripts comprising modified nucleotides - Materials and Methods are provided for producing aptamer therapeutics having modified nucleotide triphosphates incorporated into their sequence. | 2010-05-13 |
20100120025 | Compositions and Methods for Prognosis, Diagnosis, Prevention and Treatment of Cancers - The present invention provides compositions and methods of using the EPHB2 gene or its related signaling pathways to detect, prognosticate, assess the risk of, prevent, or treat cancers. Cancers amenable to the present invention include, but are not limited to, prostate cancer, breast cancer, and neuroblastoma. In one aspect, the present invention provides compositions which comprise an agent capable of eradicating or alleviating an abnormality in the EPHB2 gene or its related signaling pathways. This abnormality may cause or contribute to the development or progression of cancers. In another aspect, the present invention provides methods comprising detecting an abnormality in the EPHB2 gene or its related signaling pathways. The presence or absence of such an abnormality is indicative of the risk or disease status of cancer in a person of interest. | 2010-05-13 |
20100120026 | Particulate Substrates for Improved Recovery of Microbes - Specially modified microbial growth surfaces improve bacterial recovery or counts when testing for the presence or absence of microbial cells or performing microbial enumerations. | 2010-05-13 |
20100120027 | PROGNOSTIC TEST FOR EARLY STAGE NON SMALL CELL LUNG CANCER (NSCLC) - The invention provides methods for identifying early stage non-small cell lung cancer (NSCLC) patients who will have a favorable prognosis for the recurrence of lung cancer after surgical resection. The invention is based on the discovery that assessment of chromosomal copy number abnormalities at chromosome 10q23.3 and centromere 10 can be used for prognostic classification. The invention preferably uses fluorescence in situ hybridization with fluorescently labeled nucleic acid probes to hybridize to patient samples to quantify the chromosomal copy number of the these genetic loci. The chromosome copy number can also be determined using, for example, PCR or array CGH. Assessment of the copy number abnormality patterns with a classifier based on the relative loss of 10q23.3 signals compared to the centromere 10 signals produced statistically significant prognostic classification for NSCLC. The ratio of PTEN/CEP 10 signals, using a cutoff of 0.80, was capable of dividing patients into a group of 41 (≧0.80) in which 33 (80.5%) had the favorable prognosis, and a group of 18 (<0.80) in which 6 (33.3%) had the favorable prognosis (p=0.0008). Median times to recurrence in the former and latter groups were 83.0 and 13.0 months, respectively (p<0.0001). | 2010-05-13 |
20100120028 | PROBE, PROBE SET, PROBE-IMMOBILIZED CARRIER, AND GENETIC TESTING METHOD - A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 40 to 42 or a combination of at least two of them is used for detecting the gene of an infectious disease pathogenic bacterium. | 2010-05-13 |
20100120029 | Mutagenesis of aspergillus fungi and genes essential for growth - The present invention is directed to polynucleotides encoding proteins Essential For the Growth (EFG) of filamentous fungi. The invention also deals with namely polypeptides encoded by said polynucleotides, screening assays for identifying compounds capable of inhibiting said EFG proteins activities, pharmaceutical or phytosanitary compositions comprising such compounds. | 2010-05-13 |
20100120030 | Extracellular serine protease - The present invention provides a DNA encoding a TADG-14 protein selected from the group consisting of: (a) isolated DNA which encodes a TADG-14 protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes a TADG-14 protein; and (c) isolated DNA differing from the isolated DNAs of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a TADG-14 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell. | 2010-05-13 |
20100120031 | SYNTHESIS OF TRANS-TERT-BUTYL-2-AMINOCYCLOPENTYLCARBAMATE - The present invention concerns methods of synthesis of trans-tert-butyl-2-aminocylcopentylcarbamate comprising contacting 6-tosyl-6-azabicyclo[3.1.0]hexane with TMSN | 2010-05-13 |
20100120032 | TRANSGENIC PLANT EVENT DETECTION - The present invention relates to detection of materials derived from transgenic plant events. In particular, the invention provides methods, reagents, kits and reference materials for detecting the presence or absence in a sample of genetic material derived from and attributable to select transgenic plant events. | 2010-05-13 |
20100120033 | METHOD FOR MEASURING DNA METHYLATION - The present invention relates to a method of measuring the content of methylated DNA in a DNA region of interest in a genomic DNA contained in a biological specimen, and so on. | 2010-05-13 |
20100120034 | METHYLATION ANALYSIS OF MATE PAIRS - Various embodiments of the present teachings relate to methods for the methylation analysis of nucleic acids. The subject methods include methods that result in the preparation of mate-pair libraries suitable for highly multiplexed DNA sequencing. Embodiments include methods of preparing mate-pair libraries comprising a first tag sequence and a second tag sequence, wherein one of the tag sequences has been converted by a methylation conversion agent and the other tag sequence has not been converted by the methylation conversion agent. Other embodiments provided include intermediates for making the mate-pair library and kits for making the mate-pair libraries. Also provided is software and computer systems for analyzing the methylation levels of genomic DNA from which the tag sequences were derived. | 2010-05-13 |
20100120035 | METHOD FOR ACCURATE ASSESSMENT OF DNA QUALITY AFTER BISULFITE TREATMENT - The present invention is directed to methods useful for determining DNA quality after bisulfite treatment. The methods include a PCR-based assay, which allows ab-initio assessment of the DNA quality after bisulfite treatment and can help to prevent inaccurate quantitative measurement resulting from poor bisulfite treatment. | 2010-05-13 |
20100120036 | METHOD FOR AMPLIFYING DNA FRAGMENT - To measure the methylation degree of a genomic DNA simply and correctly as well as exhaustively, there is provided a method for amplifying a DNA fragment, characterized by comprising the following steps (1) to (5):
| 2010-05-13 |
20100120037 | METHOD FOR ISOLATING AND CULTURING UNCULTURABLE MICROORGANISMS - The invention provides a method for isolating and culturing a previously unculturable microorganism, which comprises: (i) collecting a sample from an environmental source; (ii) counting/estimating the number of microorganisms in the sample; (iii) diluting the sample in an appropriate medium; (iv) adding a gelating agent such as to entrap one or more microorganisms within a sphere of the gelating agent; (v) coating the spheres containing the entrapped microorganism(s) with a natural or synthetic polymer to form a polymeric membrane; (vi) incubating the coated spheres in the original environment for an appropriate time; (vii) cutting the spheres and scanning for microorganisms colonies; and (viii) isolating the microorganisms, and repeating steps (iii) to (vii) until a pure clone of said previously unculturable microorganism is obtained. | 2010-05-13 |
20100120038 | ASSAY METHODS FOR INCREASED THROUGHPUT OF SAMPLES AND/OR TARGETS - The present invention provides assay methods that increase the number of samples and/or target nucleic acids that can be analyzed in a single assay. | 2010-05-13 |
20100120039 | METHODS AND COMPOSITIONS IN BREAST CANCER THERAPY RESISTANCE - The present invention is directed to methods and/or compositions regarding a specific mutation in estrogen receptor alpha and their use for identifying resistance to breast cancer therapy and/or treatment therefor. More specifically, the present invention concerns presence or absence of an A908G mutation in an estrogen receptor alpha nucleic acid sequence, and/or the corresponding K303R mutation in the estrogen receptor alpha polypeptide sequence, for example, as a predictive marker for resistance to breast cancer therapy. Therapeutic embodiments for overcoming the resistance are also provided. | 2010-05-13 |
20100120040 | GENETIC POLYMORPHISMS ASSOCIATED WITH CORONARY EVENTS AND DRUG RESPONSE, METHODS OF DETECTION AND USES THEREOF - The present invention provides compositions and methods based on genetic polymorphisms that are associated with coronary heart disease (particularly myocardial infarction), aneurysm/dissection, and/or response to drug treatment, particularly statin treatment. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection. | 2010-05-13 |
20100120041 | METHODS FOR DETECTING AND TREATING KIDNEY DISEASE - A method is provided for diagnosing and monitoring kidney disease or a predisposition to kidney disease, in a subject comprising detecting pVHL, VEGF-A, CXCR4, integrin β-1, PDGF-A, HIF1α and/or TGFβ in a sample from the subject. Screening methods for test agents for inhibiting kidney disease, and therapeutic applications are also described. | 2010-05-13 |
20100120042 | METHOD OF SCREENING MATERIAL FOR IMPROVING SKIN FUNCTIONS - A method of screening a material for improving skin functions includes: (a) treating a skin cell with a candidate material; (b) detecting a change in a relative expression level of membrane-associated protein 17 (MAP17) gene; and (c) selecting a candidate material inducing the change in the expression level of the gene as a material for improving skin functions. That is to say, a material for improving skin functions is screened using MAP17 gene as a marker, on the basis of the change in the expression level of the MAP17 gene. A material for improving skin functions, which is useful in improving skin barrier function, promoting skin moisturization, preventing skin aging, or ameliorating skin troubles, may be effectively screened. | 2010-05-13 |
20100120043 | SEQUENTIAL ANALYSIS OF BIOLOGICAL SAMPLES - Methods for detecting a plurality of targets in a biological sample are provided. The method comprises contacting the biological sample with a plurality of target-binding probes simultaneously to form a plurality of target-bound probes and observing the signals from the target-bound probes sequentially. An associated kit and device for detection of the plurality of targets are also provided. | 2010-05-13 |
20100120044 | MODIFIED POLYNUCLEOTIDES COMPRISING RIBOSE RINGS - The invention pertains to different methods employing the use of a polynucleotide comprising ribose rings which carry a modification at the 2′-OH group. | 2010-05-13 |
20100120045 | GENETIC VARIANTS USEFUL FOR RISK ASSESSMENTS OF CORONARY ARTERY DISEASE AND MYOCARDIAL INFARCTION - The invention relates to methods of risk assessment and diagnosis of susceptibility to coronary artery disease and myocardial infarction, by assessing the presence or absence of alleles of certain polymorphic markers found to be associated with coronary artery disease and myocardial infarction. The invention also relates to methods for use of such polymorphic markers for predicting drug response to drugs for treating cardiovascular disease, or for monitoring the effectiveness of such drugs. The invention further relates to kits encompassing reagents for use in these methods. | 2010-05-13 |
20100120046 | Genetic Markers for Assessing Risk of Developing Bipolar Disorder - This document provides methods and materials related to genetic markers of Bipolar Disorder (BD) and Schizophrenia (SZ). For example, methods for using such genetic markers to assess risk of developing BD and/or SZ are provided, as are methods for making a differential diagnosis between BD and SZ. | 2010-05-13 |
20100120047 | PURIFICATION OF TARGET CELLS FROM COMPLEX BIOLOGICAL FLUIDS - A method for conducting a molecular analysis on target cells of a complex biological fluid can include the steps of reducing the complexity by selectively depleting at least a portion of non-target cells from the biological fluid, labeling target cells or non-target cells for identification, isolating target cells from non-target cells based on (i) a size, or (ii) a label, of the target cells or the non-target cells using a microfluidic sorting apparatus, and molecularly analyzing the target cells. Reducing can include separating the non-target cells from the biological fluid using a Magnetic Activated Cell Sorting apparatus or using magnetic beads that include a plurality of different antibodies including one or more of CD45, CD16 and 235a. Labeling can include using a label selected from fluorescent, colorimetric, magnetic and biochemical labels. The biological fluid can be selected from blood sputum, peritoneal fluid, tissue cell suspension, fine needle aspirates, fecal matter and cerebral spinal fluid. The target cells can be selected from tumor cells, fetal cells, stem cells, endothelial cells, myocardial cells and lymphocytes. The step of molecularly analyzing the target cells can include one of RNA analysis, antigen expression and mutation profiling. | 2010-05-13 |
20100120048 | ASSAYS FOR SHORT SEQUENCE VARIANTS - The invention provides assays that can detect multiple genetic variants of a gene (e.g., a mycobacterium gene) in a sample using a pool (using 2, 3, 4, or more) of oligonucletide hybridization probes. | 2010-05-13 |
20100120049 | BIOMARKERS FOR SERIOUS SKIN RASH - The present invention provides a method for predicting the risk of a patient for developing adverse drug reactions, particularly Serious Skin Rash (SSR), including such severe adverse reactions such as Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). The invention also provides a method of identifying a subject afflicted with or at risk of developing SSR. In some aspects, the methods comprise analyzing at least one genetic marker, wherein the presence of the at least one genetic marker indicates that the subject is afflicted with or at risk of developing SSR. Genetic markers useful in accordance with the methods of the invention are disclosed. | 2010-05-13 |
20100120050 | Biomarkers For Assessing Altherosclerotic Potential - The invention also provides methods, apparatuses and reagents useful for predicting future atherosclerosis based on expression levels of genes selected from the set of 68 genes with differential expression in response to pioglitazone and rosiglitazone. The invention also discloses reagent sets and biomarkers for predicting progression of atherosclerosis induced by anti-diabetic therapy in a subject. In one particular embodiment the invention provides a method for predict whether a compound will induce atherosclerosis using gene expression data from sub-acute treatments. | 2010-05-13 |
20100120051 | CYANINE DYE COMPOUNDS - Cyanine dye compounds having a negatively charged substituent that are nucleic acid stains, particularly for fluorescent staining of DNA, including compounds having the formula | 2010-05-13 |
20100120052 | Orotate Transporter Encoding Marker Genes - A recombinant marker gene encoding an orotate transporter polypeptide comprising an amino acid sequence at least 60% identical to SEQ ID NO: 2, a polynucleotide construct comprising at least one copy of the recombinant marker gene, a cell comprising at least one exogenous copy of the marker gene, and a method of selecting or identifying a cell comprising at least one copy of the recombinant marker gene, and/or selecting or identifying a cell which has been cured of the recombinant marker gene. | 2010-05-13 |
20100120053 | TISSUE ANALYSIS AND KITS THEREFOR - This invention relates to methods of analyzing a tissue sample from a subject. In particular, the invention combines morphological staining and/or immunohistochemistry (IHC) with fluorescence in situ hybridization (FISH) within the same section of a tissue sample. The analysis can be automated or manual. The invention also relates to kits for use in the above methods. | 2010-05-13 |
20100120054 | MONOMERIC AND POLYMERIC LINKERS USEFUL FOR CONJUGATING BIOLOGICAL MOLECULES AND OTHER SUBSTANCES - The present invention concerns monomeric or polymeric linker molecules useful in biological and chemical applications, their synthesis, and the synthesis and use of derivatives of the linkers conjugated to a variety of detectable labels and other substances. The linkers may be used, for example, in conjunction with fluorescent labels, nucleic acid or nucleic acid analog probes, and solid phase systems, and to enhance the solubility of the conjugated molecules. | 2010-05-13 |
20100120055 | TYROSINE PHOSPHORYLATION SITES - The invention discloses 318 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above. | 2010-05-13 |
20100120056 | DIAGNOSIS AND MONITORING OF DISEASES - The present invention relates to the diagnosis and monitoring of diseases and conditions by quantifying markers, including degradation products of disease-associated proteins, such as diketopiperazines composed of the two N-terminal amino acids or the two C-terminal amino acids of such proteins. The methods are useful for diagnosing or monitoring various diseases, including multiple sclerosis, Alzheimer's disease and ischemia. The invention further provides binding partners specific for the markers and compositions and kits for conducting the methods of the invention. | 2010-05-13 |
20100120057 | METHODS OF REDUCING NON-SPECIFIC INTERACTION IN METAL NANOPARTICLE ASSAYS - The present invention discloses methods of reducing non-specific interactions of interfering species present in a sample in metallic nanoparticle-based assays, thereby increasing the sensitivity of these assays. In particular, the methods entail neutralizing the chemical reactivity of functional groups present in interfering species by addition of a neutralizing agent, such as an alkylating agent or heavy metal ion. The methods are especially useful in assays for the detection of analytes in biological samples. Reagent kits and assay mixtures for the practice of the described methods are also disclosed. | 2010-05-13 |
20100120058 | IgE Antibodies to Chimeric or Humanized IgG Therapeutic Monoclonal Antibodies as a Screening Test for Anaphylaxis - The present invention provides an assay for detecting serum IgE antibody levels to cetuximab and to other proteins. The present invention further provides a method for predicting whether a subject will respond adversely to cetuximab treatment. The present further provides a method for detecting sensitivity to compounds comprising galactose-alpha-1,3-galactose. | 2010-05-13 |
20100120059 | INSTRUMENT SETUP SYSTEM FOR A FLUORESCENCE ANALYZER - The present invention reagents and methods for setting up an instruments having a multiplicity of detector channels for analyzing a multiplicity of fluorescent dyes. The present invention is particularly applicable in the field of flow cytometry. | 2010-05-13 |
20100120060 | METHOD FOR DETERMINING MOLECULES OR MOLECULE PARTS IN BIOLOGICAL SAMPLES - The invention relates to a method for determining molecules, molecule groups, and/or molecule parts in biological samples. The method includes spiking the sample at least once with at least one light emitting marker and measuring the light emission of the marker. Herein, it is intended that the light emission inherent to the sample is reduced or eliminated by means of bleaching prior to measuring the light emission of the marker. | 2010-05-13 |
20100120061 | RAPID IMMUNOCHROMATOGRAPHIC DETECTION BY AMPLIFICATION OF THE COLLOIDAL GOLD SIGNAL - The present invention relates to a rapid immunochromatographic test device suitable to detect an antibody and/or antigen in a sample, uses of said device for detecting diseases in a sample, a method for the production of said device as well as a kit comprising the device. | 2010-05-13 |
20100120062 | RHIZOME VIABILITY DETERMINATION METHOD - A method of determining the viability of a rhizome comprises the sequential steps of: (a) sampling material from the rhizome; (b) contacting material sampled in step (a) with an effective amount of a formulation comprising a first viability indicator; and (c) observing the action of the first viability indicator on the sampled rhizome material, to determine the viability of the rhizome. The method may further comprise one or more additional sequences involving the additional steps of: (d) contacting material sampled in step (a) with an effective amount of a formulation comprising a further viability indicator different to that used in step (b); and (e) observing the action of the further viability indicator on the sampled rhizome material, to determine the viability of the rhizome. In this way, an overall assessment of the viability of the rhizome can be made based on the action of a plurality of viability indicators, each relying on an interaction with different reagents in the plant cells. | 2010-05-13 |
20100120063 | GPCR Arrestin Assays - Sensitive assays for candidate compounds affecting GPCR activity are provided using a cell containing fusion proteins comprising a first fusion protein comprising (a) a target GPCR fused to a small fragment of β-galactosidase through a linker comprising a phosphorylation site or (b) a GPCR or a protein of interest, where the GPCR and protein of interest form a complex and one of them is fused to the small fragment of β-galactosidase; and a second fusion protein comprising arrestin fused to a large fragment of β-galactosidase. In (a), the affinity of the small and large fragments is optimized based on the background to signal ratio and the absolute signal observed. The assay is performed using a β-galactosidase substrate that provides a detectable optical signal. | 2010-05-13 |
20100120064 | ANTIBODY SPECIFIC TO INTACT HUMAN AUTOTAXIN, METHOD OF SCREENING THE SAME AND METHOD AND REAGENT FOR EXAMINING MALIGNANT LYMPHOMA BY ASSAYING AUTOTAXIN - A screening method is provided for antibody specifically recognizing naturally-occurring form of human autotaxin in a state in which it is present in the body without being denatured, comprising the steps of: binding a binding factor capable of capturing a candidate antibody of the antibody to a solid phase; binding the candidate antibody of the antibody to the binding factor; allowing naturally-occurring form of human autotaxin to react on a system in which the candidate antibody has reacted; and selecting an antibody that specifically recognizes the naturally-occurring form of human autotaxin by using as an indicator thereof the binding strength of the naturally-occurring form of human autotaxin to the antibody. Moreover, a detecting method for malignant lymphoma is provided comprising: measuring the concentration of autotaxin in a human specimen, and judging to be a malignant lymphoma in the case that value exhibits a significantly higher value than normal values comprised of measured values from normal healthy subjects. | 2010-05-13 |
20100120065 | METHOD FOR DETERMINING ENDOGLYCOSIDASE (HEPARANASE) ENZYME ACTIVITY - The present invention provides a method for determining endoglycosidase activity, and in particular of the heparanase type, in a sample, and also a method for detecting compounds that modulate the activity of endoglycosidases and in particular endoglycosidases of the heparanase type. | 2010-05-13 |
20100120066 | METHOD FOR DETECTING INTERACTIONS BETWEEN TWO AND MORE BIOLOGICAL MACROMOLECULES - Methods for detecting interactions of biomolecules include (a) preparing a cell comprising (i) a first construct comprising a bait, a first labeling material and a translocation module; and (ii) a second construct comprising a prey and a second labeling material; (b) detecting the distribution of the first construct and the second construct in the cell. The methods are simplified and show significantly high accuracy. | 2010-05-13 |
20100120067 | H. Meleagridis Assay - Methods for the detection or quantification of antibodies against | 2010-05-13 |
20100120068 | G-protein-conjugated receptor having altered ligand affinity, and use thereof - A modified G-protein-coupled receptor (GPCR), having modified ligand affinity is provided by binding a G-protein-coupled receptor to a polypeptide consisting of an amino acid sequence of SEQ ID NO: 1. Furthermore, agonists for or antagonists against the modified GPCR are screened using a transformant in which the modified GPCR has been expressed. This makes it possible to provide a technique for analyzing the function of many putative GPCRs whose entities have not been clarified. | 2010-05-13 |
20100120069 | MULTIPOTENT/PLURIPOTENT CELLS AND METHODS - Described herein are multipotent stem cells, e.g., human and other mammalian pluripotent stem cells, and related methods. | 2010-05-13 |
20100120070 | PRECISE EFFICACY ASSAY METHODS FOR ACTIVE AGENTS INCLUDING CHEMOTHERAPEUTIC AGENTS - An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested, cultured and separately exposed to a plurality of treatments and/or therapeutic agents for the purpose of objectively identifying. One particularly important tissue sample preparation technique is the initial preparation of cohesive multicellular particulates of the tissue sample. For assays concerning cancer treatment, a two-stage evaluation is contemplated in which both acute cytotoxic and longer term inhibitory effect of a given anti-cancer agent are investigated. The tissue sample technique of the present invention is also useful in assaying expression and/or secretion of various markers, factors or antigens present on or produced by the cultured cells for diagnostic purposes and for using such expression to monitor the applicability of certain candidate therapeutic or chemotherapeutic agents and the progress of treatment with those agents. | 2010-05-13 |
20100120071 | DETECTION AND MEASUREMENT OF BLOOD-FEEDING ACTIVITY - This invention provides compositions and methods for detection of hematophagous ectoparasitic activity in an enclosure or area. The compositions comprise a reagent or reagents which are reactive against antigens or markers as they appear in the excrement or other ectoparasitic materials. Such markers or antigens may be produced by the ectoparasite itself or may have been introduced into the ectoparasite because of its blood feeding activity. The method of the present invention comprises collecting from the enclosure or area, a sample comprising environmental dust or materials and subjecting the sample to tests for detecting the presence of hematophagous ectoparasitic markers, host markers or both. | 2010-05-13 |
20100120072 | DETECTION OF ELEVATED LEVELS OF HER-2/NEU PROTEIN FROM NON-ISOLATED CIRCULATING CANCER CELLS AND TREATMENT - The expression of Her-2/neu protein on circulating cancer cells in a sample of blood or peripheral blood mononuclear cells (PBMCs) is detected by performing a sensitive Her-2/neu immunoassay. There is no need to isolate the cancer cells before performing the immunoassay. A positive result indicates the expression of Her-2/neu on cancer cells in the blood sample. This method can be used to identify cancer patients who are likely to benefit from treatment with an anticancer agent that targets Her-2/neu, such as trastuzumab (HERCEPTIN), lapatinib, CP-724,714, NKI-272, and BMS-599626 | 2010-05-13 |
20100120074 | Methods and Kits for Detection of Cancer Metastasis - The invention provides a method of detecting metastasis of cancers in the body fluids from a mammal, the method comprising the steps of: (a) providing the body fluids from the mammal; and (b) the measurement of the CAS protein level or CAS polypeptide level in the body fluids to screen or diagnose the metastatic cancers. | 2010-05-13 |
20100120075 | Composition and a method for suppressing the luminescence intensity decline in a luciferin-luciferase reaction - The invention relates to compositions and methods for suppressing the luminescence intensity decline that occurs as the reaction between | 2010-05-13 |
20100120076 | METHOD FOR ANTENATAL ESTIMATION OF RISK OF ANEUPLOIDY - The present invention relates to a system and a method for evaluating the risk of carrying a fetus with genetic anomalies such as aneuploidy and in particular, to such a system and method where a screening system and method is provided to identify fetus' having trisomy-21 (Down's syndrome) with the use of biochemical marker concentrations evaluated from the maternal blood serum. | 2010-05-13 |
20100120077 | MICROFLUIDIC PARTICLE-ANALYSIS SYSTEMS - The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or analysis of particles, such as cells, viruses, organelles, beads, and/or vesicles. The invention also provides microfluidic mechanisms for carrying out these manipulations and analyses. These mechanisms may enable controlled input, movement/positioning, retention/localization, treatment, measurement, release, and/or output of particles. Furthermore, these mechanisms may be combined in any suitable order and/or employed for any suitable number of times within a system. Accordingly, these combinations may allow particles to be sorted, cultured, mixed, treated, and/or assayed, among others, as single particles, mixed groups of particles, arrays of particles, heterogeneous particle sets, and/or homogeneous particle sets, among others, in series and/or in parallel. In addition, these combinations may enable microfluidic systems to be reused. Furthermore, these combinations may allow the response of particles to treatment to be measured on a shorter time scale than was previously possible. Therefore, systems of the invention may allow a broad range of cell and particle assays, such as drug screens, cell characterizations, research studies, and/or clinical analyses, among others, to be scaled down to microfluidic size. Such scaled-down assays may use less sample and reagent, may be less labor intensive, and/or may be more informative than comparable macrofluidic assays. | 2010-05-13 |
20100120078 | Urine Stabilization System - The present disclosure relates, according to some embodiments, to a method of stabilizing a molecule (e.g., a biomolecule) in a bodily fluid comprising: (1) providing a stabilizing solution comprising: (a) an amount of a divalent metal chelator selected from the group consisting of ethylenediaminetetraacetic acid (EDTA), (ethylenebis(oxyethylenenitrilo))tetraacetic acid (EGTA), and 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid (BAPTA) and salts thereof in the range of from about 0.001 M to about 2 M; and (b) an amount of at least one chelator enhancing component selected from the group consisting of lithium chloride, guanidinium chloride, guanidinium thiocyanate, sodium salicylate, sodium perchlorate, and sodium thiocyanate in the range of from about 0.1 M to about 10 M; and (2) adding the stabilizing solution to the bodily fluid, thus stabilizing the molecule. A biomolecule may be selected from a nitrite, a carbohydrate, a ketone, a globin, a bilirubin, a lipid, and combinations thereof in some embodiments. | 2010-05-13 |
20100120079 | Trans-Differentiation And Re-Differentiation Of Somatic Cells And Production Of Cells For Cell Therapies - The invention provides a method for effecting the trans-differentiation of a somatic cell, i.e., the conversion of a somatic cell of one cell type into a somatic cell of a different cell type. The method is practiced by culturing a somatic cell in the presence of at least one agent selected from the group consisting of (a) cytoskeletal inhibitors and (b) inhibitors of acetylation, and (c) inhibitors of methylation, and also culturing the cell in the presence of agents or conditions that induce differentiation to a different cell type. The method is useful for producing histocompatible cells for cell therapy. | 2010-05-13 |
20100120080 | CANCER DIAGNOSIS USING KI-67 - The present invention provides methods and compositions for detection, diagnosis, prognosis, monitoring treatment and monitoring progression of cancer by detecting the level of Ki-67 protein in an individual. | 2010-05-13 |
20100120081 | HIGH SENSITIVITY PARAMETERS FOR THE DETECTION OF VITAMIN B12 AND/OR FOLATE DEFICIENCIES AND METHODS OF USE - Described herein are high sensitivity parameters useful for the detection of vitamin B12 and/or folate deficiencies. Methods of determining susceptibility for vitamin B12 and/or folate deficiency in a subject are also provided. Methods of determining the progress and assessment of treatment of these deficiencies are provided. | 2010-05-13 |
20100120082 | Optimization of Process Variables in Oxygen Enriched Fermentors Through Process Controls - Methods and systems are provided for controlling the addition of oxygen in fermentations to achieve a desired oxygen consumption and substrate yield in fermentation cell cultures. In one aspect, the invention provides a method for regulating the addition of oxygen (O | 2010-05-13 |