20th week of 2009 patent applcation highlights part 42 |
Patent application number | Title | Published |
20090123930 | METHODS AND COMPOSITIONS FOR DIAGNOSTIC USE IN CANCER PATIENTS - Disclosed herein are methods and compositions useful for identifying therapies likely to confer optimal clinical benefit for patients with cancer. | 2009-05-14 |
20090123931 | IDENTIFICATION OF TISSUE FOR DEBRIDEMENT - Provided are methods of determining whether a cell in a tissue site is viable or nonviable. Also provided are methods of debriding tissue from a tissue site. Further provided are kits comprising a compound that distinguishes between viable and nonviable cells and instructions for using the compound on a tissue site. Additionally, the use of a compound that distinguishes between viable and nonviable cells is provided, where the use is to determine whether a cell in a tissue site is viable or nonviable. Also provided is a use of a compound that distinguishes between viable and nonviable cells, where the use is for the manufacture of the above-described kit. | 2009-05-14 |
20090123932 | QUANTITATIVE TEST TO DETECT DISEASE PROGRESSION MARKERS OF EPITHELIAL OVARIAN CANCER PATIENTS - The present invention concerns a method of prognosing the risk of early ovarian cancer relapse in a subject having ovarian cancer comprising: a) detecting the level of at least one marker selected from the group consisting of BTF4, GCS and HLA-DRbeta1; and b) comparing the level of the above at least one marker with that of a corresponding control sample, wherein the detection of a lower level of the at least one marker compared to that in the control sample is indicative that the subject is at risk of early cancer relapse. Also provided is a method of stratifying a subject suffering from ovarian cancer based on the expression levels of the disclosed markers and kits for practicing the methods of the present invention. | 2009-05-14 |
20090123933 | MICRORNA BIOMARKERS IN LUPUS - The present invention provides methods of screening a subject for systemic lupus erythematosus (SLE), comprising detecting an increase in an amount of one or more markers associated with SLE in a biological sample from the subject, wherein the one or more markers is selected from the group consisting of miR-16-1, miR-16-2, miR-223, let7a-1, let7a-2. let7a-3, let 7c, let7g, and any combination thereof, whereby detection of the increase in the amount of the one or more markers identifies the subject as having SLE. The invention further provides methods of screening a subject for SLE comprising detecting a decrease in miR-95 in a biological sample from the subject, whereby detection of the decrease in the amount of miR-95 identifies the subject as having SLE. | 2009-05-14 |
20090123934 | Inhibition of polo kinase by matrimony maintains G2 arrest in the meiotic cell cycle - Matrimony (Mtrm) acts as a negative regulator of Polo kinase (Polo) during the later stages of G2 arrest. Indeed, both the repression of Polo expression until stage 11 and the inactivation of newly synthesized Polo by Mtrm until stage 13 play critical roles in maintaining and properly terminating G2 arrest. Our data suggest a model in which the eventual activation of Cdc25 by an excess of Polo at stage 13 triggers NEB and entry into prometaphase. In view of the foregoing, methods for modulating oocyte maturation are provided. More particularly, methods are provided for in vitro maturation of an oocyte. Further provided are methods for identifying functional orthologs of a | 2009-05-14 |
20090123935 | Measurement of a population of nucleic acids, in particular by real time PCR - The invention relates to a method for measuring the amount of nucleic acids of a target sequence in a sample of interest. The method comprises several steps, and in particular subjecting the sample of interest to an amplification treatment, in the presence of at least one nucleic acids label specific for said target sequence; measuring a physical quantity representative of the evolution of the label; calculating a parameter F | 2009-05-14 |
20090123936 | CONFORMATIONALLY ABNORMAL FORMS OF TAU PROTEINS AND SPECIFIC ANTIBODIES THERETO - The invention relates to antibodies with a specificity to an abnormally truncated form of tau protein, which is conformationally different from normal tau, and does not bind to normal tau protein, conformationally different tau proteins (“tauons”) and diagnostic and therapeutical aspects in relation to Alzheimer's disease and related tauopathies. | 2009-05-14 |
20090123937 | Methods of selecting epidermal growth factor receptor (EGFR) binding agents - The present application relates to methods of selecting EGFr binding agents. In certain embodiments, such EGFr binding agents bind to at least a portion of a panitumumab epitope on an EGFr. In certain embodiments, such EGFr binding agents do not bind to a panitumumab epitope on an EGFr. | 2009-05-14 |
20090123938 | Mammalian monocyte chemoattractant protein receptors - Novel human chemokine receptors, MCP-1RA and MCP-1RB, and processes for producing them are disclosed. The receptors, which are alternately spliced versions of MCP-1 receptor protein may be used in an assay to identify antagonists of MCP-1 which are therapeutically useful in the treatment of atherosclerosis and other diseases characterized by monocytic infiltrates. | 2009-05-14 |
20090123939 | Biologically enhanced electrically-active magnetic nanoparticles for concentration, separation, and detection applications - The disclosure generally relates to a particulate composition formed from a conductive polymer (e.g., conductive polyanilines, polypyrroles, polythiophenes) bound to magnetic nanoparticles (e.g., Fe(II)- and/or Fe(III)-based magnetic metal oxides). The particulate composition can be formed into a biologically enhanced, electrically active magnetic (BEAM) nanoparticle composition by further including a binding pair member (e.g., an antibody) bound to the conductive polymer of the particulate composition. Methods and kits employing the particulate composition and the BEAM nanoparticle composition also are disclosed. | 2009-05-14 |
20090123940 | MOLECULES INVOLVED IN SYNAPTOGENESIS AND USES THEREFOR - The present invention is based on the discovery that neuronal pentraxins play a role in the clustering and internalization of AMPA receptors, synaptogenesis, and metabotropic glutamate receptor-mediated long term depression (LTD) of a synapse. Accordingly, there are provided methods of identifying compounds that that modulate mGluR-mediated AMPA receptor internalization and LTD. Further provided are cleavage products of a member of the neuronal pentraxin family, neuronal pentraxin receptor (NPR). Also provided are isolated peptides comprising the Narp association regions 1 and 2 (NAR1 and NAR2, respectively) and the Narp binding motif (NBM) of AMPA receptors. Finally, there are provided antibodies that block binding of neuronal pentraxins to AMPA receptors, in particular, antibodies that bind NAR1, or NAR2, or NBM. | 2009-05-14 |
20090123941 | METHOD AND KIT FOR DETECTING THE EARLY ONSET OF RENAL TUBULAR CELL INJURY - A method and kit for detecting the early onset of renal tubular cell injury, utilizing NGAL as an early urinary biomarker. NGAL is a small secreted polypeptide that is protease resistant and consequently readily detected in the urine following renal tubule cell injury. NGAL protein expression is detected predominantly in proximal tubule cells, in a punctate cytoplasmic distribution reminiscent of a secreted protein. The appearance NGAL in the urine is related to the dose and duration of renal ischemia and nephrotoxemia, and is diagnostic of renal tubule cell injury and renal failure. NGAL detection is also a useful marker for monitoring the nephrotoxic side effects of drugs or other therapeutic agents. | 2009-05-14 |
20090123942 | Electrophysiological assays using oocytes that express human enac and the use of phenamil to improve the effect of enac enhancers in assays using membrane potential reporting dyes - In one aspect, the present invention relates to a mammalian cell-based high-throughput assay for the profiling and screening of human epithelial sodium channel (hENaC) cloned from a human kidney c-DNA library and is also expressed in other tissues including human taste tissue. The present invention further relates to amphibian oocyte-based medium-throughput electrophysiological assays for identifying human ENaC modulators, preferably ENaC enhancers. Compounds that modulate ENaC function in a cell-based ENaC assay are expected to affect salty taste in humans. The assays described herein have advantages over existing cellular expression systems. In the case of mammalian cells, such assays can be run in standard 96 or 384 well culture plates in high-throughput mode with enhanced assay results being achieved by the use of a compound that inhibits ENaC function, preferably an amiloride derivative such as Phenamil. In the case of the inventive oocyte electrophysiological assays (two-electrode voltage-clamp technique), these assays facilitate the identification of compounds which specifically modulate human ENaC. The assays of the invention provide a robust screen useful to detect compounds that facilitate (enhance) or inhibit hENaC function. Compounds that enhance or block human ENaC channel activity should thereby modulate salty taste in humans. | 2009-05-14 |
20090123943 | Characterization and Identification of Unique Human Adiponectin Isoforms and Antibodies - The invention pertains to methods for measuring different forms of human adiponectin that are present in human plasma/serum, and more specifically methods are based on an ELISA assay that utilizes different monoclonal antibodies directed against adiponectin, in combination with different polyclonal antibodies directed against different domains of human adiponectin. The invention also provides unique isoforms of adiponectin and antibodies thereto, including polyclonal and monoclonal antibodies. | 2009-05-14 |
20090123944 | Bioassays - The invention relates to vectors encoding bioassay receptors and in vitro bioassays using said bioassay receptors for assessing compounds of interest. In particular, the bioassays provide a generic platform for the comparison of binding of different ligands to their respective receptors or binding partners in the presence and/or absence of a compound of interest. | 2009-05-14 |
20090123945 | CHOLINERGIC/SEROTONINERGIC RECEPTOR AND USES THEREOF - The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of α7 nicotinic acetylcholine receptors. | 2009-05-14 |
20090123946 | IMMUNOASSAYS AND KITS FOR THE DETECTION OF NGAL - The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample. | 2009-05-14 |
20090123947 | Analytical Sandwich Test for determining NT-proBNP - The present invention concerns an immunological test for determining NT-proBNP comprising at least two antibodies to NT-proBNP, wherein at least one of the antibodies to NT-proBNP is a monoclonal antibody. The epitopes recognized by the antibodies can slightly overlap. | 2009-05-14 |
20090123948 | Autoantibody detection for cancer diagnostics - The present invention relates to compositions and methods for the detection of anti-ECPKA autoantibodies in a biological sample, and to the use of such compositions and methods in the diagnosis of cancer in humans and non-human mammals. | 2009-05-14 |
20090123949 | METHODS FOR DETERMINING THE PROGNOSIS FOR CANCER PATIENTS USING TUCAN - The invention provides methods for determining a prognosis for survival for a cancer patient. One method involves (a) measuring a level of a TUCAN in a neoplastic cell-containing sample from the cancer patient, and (b) comparing the level of TUCAN in the sample to a reference level of TUCAN, wherein a low level of TUCAN in the sample correlates with increased survival of the patient. Another method involves (a) measuring a level of TUCAN in a neoplastic cell-containing sample from the cancer patient, and (b) classifying the patient as belonging to either a first or second group of patients, wherein the first group of patients having low levels of TUCAN is classified as having an increased likelihood of survival compared to the second group of patients having high levels of TUCAN. | 2009-05-14 |
20090123950 | Generation And Profiling Of Fully Human Hucal Gold.RTM.-Derived Therapeutic Antibodies Specific For Human CD38 - The present invention provides novel methods for using recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for CD38, which plays an integral role in various disorders or conditions. These methods take advantage of newly discovered antibodies and surprising properties of such antibodies, such as the ability to bind CD38 of minipig origin and the ability to induce, by cross-linking, specific killing of cells that express CD38. These antibodies as well as the novel methods for using those antibodies can be used to treat, for example, hematological malignancies such as multiple myeloma. | 2009-05-14 |
20090123951 | Method Of Diagnosing A Body Weight Condition Or Predisposition - A method for diagnosing a body weight condition or predisposition to a body weight condition in an animal by determining observed level(s) of at least one biomarker in a tissue or biofluid sample from the animal and comparing the observed level(s) to reference level(s) for the biomarker; wherein the observed level(s) relative to the reference level(s) are individually or collectively indicative of the body weight condition or predisposition. | 2009-05-14 |
20090123952 | Method of Measuring Amyloid-Beta Peptides - The present invention relates to methods for measuring Aβ peptides in a sample, particularly a sample of blood, such as whole blood and plasma, and to methods of determining whether a compound alters the amount of Aβ produced by a cell or animal. | 2009-05-14 |
20090123953 | Double brilliance beta-arrestin: a biosensor for monitoring the activity of receptors and signalling molecules, and method of using same - An intramolecular bioluminescence resonance energy transfer (BRET), biosensor for monitoring receptor activity and signalling cascades is disclosed. The “double-brilliance” biosensor sandwiches β-arrestin (β-arr) between Renilla | 2009-05-14 |
20090123954 | MULTICOLOR BIOLUMINESCENT VISUALIZATION PROBE SET, OR SINGLE-MOLECULE-FORMAT MULTICOLOR BIOLUMINESCENT VISUALIZATION PROBE - The present invention provides ligand detection means capable of exhibiting two-dimensional information (wavelength and intensity of luminescent signal) responding to multiple signals triggered by a ligand via a target protein, while taking advantage of the merit of the single-molecule-format bioluminescent probe. | 2009-05-14 |
20090123955 | Size Self-Limiting Compositions and Test Devices for Measuring Analytes in Biological Fluids - A test strip or electrochemical sensor for measuring the amount of an analyte in a hiological fluid, e.g., the glucose content of whole blood, includes a size self-limiting reagent formulation employing an enzyme system for reaction with the analyte, the reactive system mixed into a water-soluble swellable polymer matrix containing small water-insoluble particles having a nominal size of about 0.05 to 20 μm, preferably about 1 to 10 μm. The weight ratio of the water-insoluble particles to the water-soluble swellable polymer matrix is about 1/2 to 2/1. The reagent formulation is deposited onto a non-porous substrate to form a thin layer about 6-16 μm thick, providing a rapid and stable response to application of a sample, while being insensitive to the amount of the sample. | 2009-05-14 |
20090123956 | Measurement of the oxidants-antioxidants balance in liquids - The present invention describes a chemical method that can determine the oxidant-antioxidant balance in biological samples and other materials. In the example of the application of the invention that is presented in the description of the invention section 3,3′,5,5′-Tetramethylbenzidine (TMB) and its cation that has a characteristic color are used as an oxidation-reduction target. However any other substance that can change its optical, fluorescence luminescence properties upon oxidation or reduction could be used in its place. The invention can be applied in any shape of vessel and on a stable matrix as a dipstick. The invention is based on two reactions one redox and one enzymatic that take place at the same time. In a redox reaction, e.g. TMB cation will be reduced by antioxidants; in the enzymatic reaction, intact TMB will be oxidized by peroxides. In the process of reduction, TMB cation will be decolourized; and in the process of oxidation, intact TMB will be converted to a colour cation. After a period of the time and adding HCl, the amount of TMB cation can be easily measured by spectrophotometry at 450 nm (reference wavelength 620 or 570 nm) both by macro- and micromethods (ELISA reader). The quantitative amount of TMB cation is representative of the oxidants-antioxidants balance in sample. This is achieved by comparing the optical absorbance of each sample with the absorbance of a series of standards that comprise the standard curve. The standard solutions can be constructed by mixing varying proportions (0-100%) of hydrogen peroxide (as a representative of the oxidants) with uric acid (as a representative of the antioxidants). However the admixture of any other oxidant-antioxidant may be used. The invention can be useful for the evaluation of the oxidant-antioxidant balance in biological samples (serum, plasma, urine etc.) especially for the evaluation of age related and metabolic disease such as diabetes. In addition the invention may be useful for the estimation of the success of antioxidant therapy. | 2009-05-14 |
20090123957 | CANINE COX-2 PROTEINS AND USES THEREOF - The present invention relates to canine COX-1 and COX-2 proteins; to canine COX-1 and COX-2 nucleic acid molecules, including those that encode such COX-1 and COX-2 proteins, respectively; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such inhibitory compounds, particularly those that specifically inhibit COX-2 activity, as well as the use of such therapeutic compositions to treat animals. | 2009-05-14 |
20090123958 | Laboratory Devices, Methods and Systems Employing Acoustic Ejection Devices - A method for performing chemically analyzing samples (e.g. bodily fluids) dispensed with an acoustic ejection device is disclosed. A method preparing a sample for analysis by centrifuging the sample in a sample collection device in fluid communication with an acoustic ejection device is disclosed. A method for laboratory analysis of biological and/or other fluids, wherein a single electromechanical pump including an acoustic ejection device draws and ejects fluids is disclosed. A device for dispensing a fluid, where a ratio between a reservoir of the device and an ejection chamber is between 50 and 4,000 is disclosed. A system including a plurality of acoustic ejection devices in an environmentally enclosed housing is disclosed. | 2009-05-14 |
20090123959 | MICROORGANISM DISCRIMINATOR AND METHOD - A microorganism discriminator is disclosed, including a housing to incubate a sample in low-light conditions; a illuminator to irradiate the sample with a monochromatic blue light; an injector disposed in the housing, to deliver a viability discriminating dye to the sample; and a base connected to the housing and the illuminator, to transport the sample to the housing and to the illuminator. A method of discriminating viable microorganisms in a sample is disclosed, the method including: applying a sample to a filter; applying a viability discriminating dye to the filter, in a low-light environment; incubating the sample in the low-light environment; illuminating the filter with monochromatic blue light; and performing quantitative polymerase chain reaction (QPCR) on the sample. | 2009-05-14 |
20090123960 | Method for Removing Antibiotics From Blood Culture Samples - Methods for removing inhibitors of microbial growth, including antibiotics, from a biological sample suspected of containing one or more microorganisms are provided. The methods include contacting a sample, or a culture growth medium containing the sample, with reversed-phase adsorbent media, which remove the inhibitors of microbial growth, but allow the microorganisms of interest to remain in the sample or culture growth medium. | 2009-05-14 |
20090123961 | MICROFLUIDIC DEVICE HAVING STABLE STATIC GRADIENT FOR ANALYZING CHEMOTAXIS - A microfluidic method and device for testing and analyzing chemotaxis by providing a stable, static fluid gradient. The device includes a sink reservoir for receiving biological cellular material and a source reservoir for receiving a chemoattractant. The biological cellular material migrates through a low fluid volume microfluidic gradient channel located between the source and sink reservoirs. The fluid in the gradient channel is static and stable due to a high fluid volume closed circuit bypass microfluidic channel also in fluid communication with the source and sink reservoirs, whereby the bypass channel relieves any pressure differential imparted across the gradient channel. | 2009-05-14 |
20090123962 | Chemical Sensing Device - The present application relates to a chemical sensing device for detecting an analyte in a liquid sample containing suspended particles. The device comprises a radiation source adapted to generate electromagnetic radiation, a transducer ( | 2009-05-14 |
20090123963 | BIOPSY SAMPLE MOUNT AND PROCESSING METHOD - A biopsy sample mount and processing method. One embodiment of the sample mount includes a rounded mass of hydrophilic or liquid absorbing material. Tissue samples can be releasably placed on the material mass in a known structural orientation and the mount and sample immersed in fixative. The mass of material will swell when absorbing the fixative, causing the tissue sample to release from the mass of material. The tissue sample is then removed from the fixative and correctly oriented for tissue processing for diagnostic use. | 2009-05-14 |
20090123964 | Novel Gene GMS 08 - The present invention relates to microorganisms genetically engineered to increase yield and/or efficiency of biomass production from a carbon source, such as e.g. glucose. Processes for generating such microorganisms are also provided by the present invention. The invention also relates to polynucleotide sequences comprising genes that encode proteins that are involved in the bioconversion of a carbon source such as e.g. glucose into biomass. The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. Also included are processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms leading to a microorganism with reduced carbon source diversion, i.e. higher yield and/or efficiency of biomass production from a carbon source such as e.g. glucose. | 2009-05-14 |
20090123965 | Hydrolysis Process For Raw Materials From The Fishing And Slaughterhouse Industries And Tanks For Use Therein - Method for an enzymatic hydrolysis process of collagen and raw materials containing proteins. The raw materials undergo enzymatic hydrolysis to produce the three layers: a top layer containing fat, a mid layer comprising water soluble constituents, and a non-soluble bottom layer comprising bones and non-soluble proteins. These layers are separated and the second layer is further separated, in that it is cooled a time period sufficient for the forming of two layers: a bottom layer containing partially or wholly set collagen, and a liquid top layer containing the remaining water soluable proteins. The last layer is removed; and the other is heated until it becomes liquid. A hydrolysis tank | 2009-05-14 |
20090123966 | Hybrid portable origin of replication plasmids - The invention relates to modifying plasmid origins of replication to create hybrid origins of replication containing nucleotide sequences from more than one plasmid. The invention also relates to a modified origin of replication cassette that is portable or exchangeable due to the creation of multiple cloning sites flanking the origin of replication. Methods and plasmids for use in exchanging origins of replication are disclosed. Such modified or hybrid plasmids provide useful cloning tools that allow for regulation of the level of expression of a desired protein. | 2009-05-14 |
20090123967 | Modified spider silk proteins - The present invention is directed to a method of modifying a spider silk protein and a spider silk protein obtainable by said method. The invention further pertains to a nucleic acid sequence coding for a modified spider silk protein, a vector containing said sequences and host cells transformed with this vector. The invention furthermore is directed to a pharmaceutical or cosmetical composition containing a modified spider silk protein as defined herein and the use of said modified sequences in various fields, in particular in the fields of medicine, cosmetics and technical applications. | 2009-05-14 |
20090123968 | Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides - Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses. | 2009-05-14 |
20090123969 | NOVEL FLUORESCENT PROTEIN AND GENE ENCODING THE SAME - The present invention provides a novel fluorescent protein the wavelength of the maximum of the fluorescence of which exists in a wavelength side longer than 510 nm, and which exhibits yellow fluorescence or yellowish green fluorescence and can be expressed in a heterogeneous cell, and a gene encoding the same, wherein the fluorescent protein has an amino acid sequence as set forth in SEQ ID NO: 1 and it is a fluorescent protein derived from a copepod taxonomically classified to | 2009-05-14 |
20090123970 | GLYCOSYLATED MAMMALIAN NGAL AND USE THEREOF - The present invention relates to glycosylated mammalian NGAL, and methods of using said glycosylated mammalian NGAL. | 2009-05-14 |
20090123971 | Compositions of aminoacyl-tRNA synthetase and uses thereof - Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs. | 2009-05-14 |
20090123972 | Staphylococcal nuclease fusion proteins for the production of recombinant peptides - Peptides are produced as fusions with a suitable carrier protein. The carrier protein disclosed herein are adapted from the N-terminal domain of | 2009-05-14 |
20090123973 | Methods of Making Modular Fusion Protein Expression Products - The invention relates to methods of making modular chimeric protein expression products and compositions utilized in the methods. In particular, the invention relates to sequential, directional cloning of polynucleotides encoding polypeptide modules. Each clonable element or module contains an open reading frame of interest flanked by predetermined restriction sites. The methods include using modules and vectors containing these modules as starting materials for recombinant DNA techniques. One advantage of the invention is that it allows for many variations of fusion proteins to be made quickly and easily without needing to design and evaluate each subsequent cloning step. | 2009-05-14 |
20090123974 | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules - Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated by cytokines. | 2009-05-14 |
20090123975 | FEED MEDIA - The invention provides stable feed media containing pyruvate and methods for stabilizing feed media by adding pyruvate. The invention further provides methods for producing proteins using such media and proteins produced through the use of such methods. | 2009-05-14 |
20090123976 | Compositions and Method for Storage of Nucleic Acid From Bodily Fluids - An aqueous composition comprising a denaturing agent, a chelator, a buffering agent and a protease for the extraction of nucleic acid from a sample of bodily fluid, such as saliva, such that the extracted nucleic acid is stable for at least fourteen days at room temperature and can be directly utilised in an amplification reaction without further processing. In particular, said composition comprises SDS, Cyclohexanediamine tetraacetate, Tris-HCl and proteinase K. A method and kit for the amplification of DNA directly from a bodily fluid, comprising said composition, is further provided. | 2009-05-14 |
20090123977 | System for capturing and modifying large pieces of genomic DNA and constructing organisms with synthetic chloroplasts - The functional analysis of genes frequently requires the manipulation of large genomic regions. A yeast-bacteria shuttle vector is described that can be used to clone large regions of DNA by homologous recombination. Also described is a method for isolating entire genomes, including chloroplast genomes, or large portions thereof, and manipulating the same. Also described are methods for determining minimal genomes, minimal pathway requirements, and minimal organelle genomes. | 2009-05-14 |
20090123978 | BIOLOGICAL SAMPLE REACTION CHIP AND BIOLOGICAL SAMPLE REACTION METHOD - A biological sample reaction chip, including: a plurality of reaction vessels; a first channel connected to one end of each of the reaction vessels and comprising an opening for introducing a reaction solution; and a second channel connected to the other end of each of the reaction vessels, wherein when a capillary force of the first channel is defined as A, while a capillary force of connected portions between the reaction vessels and the first channel as B, a capillary force of the reaction vessels as C, a capillary force of connected portions of the second channel and the reaction vessels as D, and a capillary force of the second channel as E, the following is established: A | 2009-05-14 |
20090123979 | Methods of reducing the inhibitory effect of a tannin on the enzymatic hydrolysis of cellulosic material - The present invention relates to methods of producing a cellulosic material reduced in a tannin, comprising treating the cellulosic material with an effective amount of a tannase to reduce the inhibitory effect of the tannin on enzymatically saccharifying the cellulosic material. The present invention also relates to methods of saccharifying a cellulosic material, comprising: treating the cellulosic material with an effective amount of a tannase and an effective amount of a cellulolytic enzyme composition, wherein the treating of the cellulosic material with the tannase reduces the inhibitory effect of a tannin on enzymatically saccharifying the cellulosic material with the cellulolytic enzyme composition. The present invention also relates to methods of producing a fermentation product, comprising: (a) saccharifying a cellulosic material with an effective amount of a cellulolytic enzyme composition; (b) fermenting the saccharified cellulosic material of step (a) with one or more fermenting microorganisms to produce a fermentation product; and (c) recovering the fermentation product, wherein the cellulosic material is treated with an effective amount of a tannase to reduce the inhibitory effect of a tannin on enzymatically saccharifying the cellulosic material. | 2009-05-14 |
20090123980 | PROCESS FOR PRODUCING L-ARGININE, L-ORNITHINE OR L-CITRULLINE - The present invention provides a polypeptide which has: (i) an amino acid sequence wherein one or more amino acid residues are substituted in the region at positions 20 to 38 from the N terminus of the amino acid sequence shown in SEQ ID NO: 1; or (ii) an amino acid sequence wherein one or more amino acid residues are substituted in the region at positions 20 to 38 from the N terminus of the amino acid sequence shown in SEQ ID NO: 1 and one or more amino acid residues are deleted, substituted or added in the region at positions 1 to 19 or 39 to 294; and which has N-acetylglutamate kinase activity. | 2009-05-14 |
20090123981 | XYLAN-UTILIZATION REGULON FOR EFFICIENT BIOPROCESSING OF HEMICELLULOSE AND USES THEREOF - The subject invention provides at least one nucleic acid sequence encoding an aldouronate-utilization regulon isolated from | 2009-05-14 |
20090123982 | Triglyceride Process - A process for producing triglycerides which comprises: (a) subjecting a first triglyceride comprising at least 40% by moles of oleic acid residues, based on total acyl groups in the triglyceride, to an alcoholysis reaction with an alcohol having from 1 to 6 carbon atoms to obtain a composition comprising 2-oleoyl monoglyceride and at least one acyl ester of said alcohol; (b) reacting the 2-oleoyl monoglyceride with an acylating agent comprising at least one C12 to C24 saturated fatty acid, at least one ester of said fatty acid or a mixture thereof, to obtain a 1,3-saturated fatty acid acyl 2-oleoyl glyceride; and (c) separating at least a part of the at least one acyl ester after or during step (a) or step (b); (d) reacting the acyl ester with a second glyceride to form 1,3-dioleoyl 2-palmitoyl glyceride. | 2009-05-14 |
20090123983 | Processes for preparing an intermediate of sitagliptin via enzymatic reduction - The invention provides enzymatic reduction processes for the preparation of 4-(2,4,5-trifluorophenyl)-3-hydroxybutanoate, particularly, (S)-methyl 4-(2,4,5-trifluorophenyl)-3-hydroxybutanoate, a key intermediate in the synthesis of Sitagliptin, and the (S)- and (R)-enantiomers of methyl 4-(2,4,5-trifluorophenyl)-3-hydroxybutanoate in high enantiomeric purity. | 2009-05-14 |
20090123984 | Transformed plants accumulating terpenes - The present invention relates to transformed plants with an altered terpene content, preferably over-accumulating a mono- or sesqui-terpene. By transformation of plants with genes encoding terpene synthases (TS), and prenyl transferases (PRT), plants accumulating at least 1000 ng/per g of fresh leaf of a specific terpene were obtained. The present invention provides an advantageous system for production of terpenes in that any desired mono- or sesqui-terpene at the choice of the skilled person can be produced in plants. Preferably, the transformed plants contain at least one recombinant plastid targeted TS and PRT. | 2009-05-14 |
20090123985 | METHOD FOR FABRICATING AEROGELS AND THEIR APPLICATION IN BIOCOMPOSITES - The present invention discloses a method for fabricating aerogels, a method for fabricating surface-modified aerogels, and a method for fabricating biocomposites. Take the fabricating method of biocomposites for example, first, a precursor solution is provided and the precursor solution comprises a hydrophilic ionic liquid, a catalyzed hydrolysis and/or condensation reagent, at least one biomolecule. Next, a curing process is performed for the precursor solution to hydrolyze and polymerize the at least one alkoxide monomer and/or aryloxide monomer to wrap at least one biomolecule and thus form biocomposite. Afterwards, an extracting process is performed by a solvent for the biocomposite to substitute the ionic liquid in the biocomposite. Finally, a drying process for the biocomposite is carried out after the extracting process so as to remove the solvent in the biocomposite. Therefore, the biocomposite is formed. | 2009-05-14 |
20090123986 | Nematode Phosphoethanolamine N-Methyltransferase-Like Sequences - Nucleic acid molecules from nematodes encoding phosphoethanolamine n-methyltransferase polypeptides are described. PEAMT-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PEAMT-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production. | 2009-05-14 |
20090123987 | Extracting and purifying limit dextrinases - The invention relates to improved methods for extracting and purifying limit dextrinase enzymes from cells, in particular plant cells. The process of the invention includes heating a cell homogenate at 4O° C., in the presence of divalent cations thus increasing the specific activity of the limit dextrinase. | 2009-05-14 |
20090123988 | METHOD FOR THE SPECIFIC OR NON-SPECIFIC SEPARATION OF CELLS AND/OR VIRUSES FROM LIQUID MEDIA AND THE USE THEREOF - The invention relates to a method for the specific or non-specific separation of cells and/or viruses from liquid media which is based on adsorption of the species on a correspondingly functionalised carrier material. The method according to the invention is used for separation and also isolation of any species of cells and viruses. | 2009-05-14 |
20090123989 | VIRUS PURIFICATION USING ULTRAFILTRATION - The invention provides a method for the purification, of a virus comprising a step of ultrafiltration wherein the reteniate contains the virus, wherein back pressure of at least 5 kPa is applied on the permeate side. The invention also provides a method for purification of a recombinant adenovirus, said method consisting essentially of: a) culturing cells that are infected with said recombinant adenovirus, b) lysing said cells and removing free nucleic acid, to provide a lysate comprising the recombinant adenovirus, c) clarifying the lysate to obtain an adenovirus preparation, d) subject the adenovirus preparation to ultrafiltration, wherein the adenovirus preparation is in the retentate, to concentrate the adenovirus preparation, e) subjecting the adenovirus preparation of step d) to ultrafiltration, wherein the adenovirus preparation is in the retenate and exchanging it with at least 5 diafiltration volumes (DFVs) of buffer, wherein in steps d) and e) back pressure of at least 5 kPa is applied on the permeate side. | 2009-05-14 |
20090123990 | COMPOSITION COMPRISING ENZYMATICALLY DIGESTED YEAST CELLS AND METHOD OF PREPARING SAME - The present invention relates to the field of fermentation media. More specifically, the invention provides a method for preparing a composition useful for culturing microbial cells wherein whole and/or autolysed yeast cells are enzymatically treated to obtain the composition. The microbial cultures obtained have increased stability and are useful in the manufacturing of food, feed and as a pharmaceutical product. | 2009-05-14 |
20090123991 | RETRONS FOR GENE TARGETING - The invention provides methods and nucleic acid constructs that may be used to modify a nucleic acid of interest at a target locus within the genome of a host. In some aspects, the invention contemplates producing in vivo a gene targeting substrate (GTS), which may be comprised of both DNA and RNA components. The gene targeting substrate may comprise a gene targeting nucleotide sequence (GTNS), which is homologous to the target locus, but comprises a sequence modification compared to the target locus. The gene targeting substrate may be produced by reverse transcription of a gene targeting message RNA (gtmRNA). The gene targeting message RNA may be folded for self-priming for reverse transcription by a reverse transcriptase. The gene targeting message RNA may in turn be the product of transcription of a gene targeting construct (GTC) encoding the gene targeting message RNA. The gene targeting construct may for example be a DNA sequence integrated into the genome of the host, or integrated into an extrachromosomal element. Following expression of the gene targeting systems of the invention, hosts may for example be selected having genomic modifications at a target locus that correspond to the sequence modification present on the gene targeting nucleotide sequence. In some embodiments, the structure of retrons may be adapted for use in the gene targeting systems of the invention. | 2009-05-14 |
20090123992 | Shape-Shifting Vitrification Device - This invention is a storage device (cryocontainer) for the vitrification method of cryopreservation that uses shape memory materials to create a novel shape-shifting feature in which the relevant heat transfer zone of the cryocontainer can be thermally morphed between a shape conducive to biological specimen handling and to a shape conducive to rapid heat transfer. This feature utilizes the temperature induced phase transformation of shape memory materials. The temperature inducement occurs naturally within the normal temperature changes that occur during vitrification. | 2009-05-14 |
20090123993 | BIOREACTOR FOR DEVELOPMENT OF BLOOD VESSELS - The present invention provides a blood vessel bioreactor and accessory system to harvest, maintain, transport, and/or develop a native blood vessel or a tissue-engineered biosynthetic blood vessel construct in which regulated nutritive fluid flow as well as a pressure and shear stress regimen is supplied which nutritionally and mechanically conditions the native or tissue-engineered blood vessel construct to withstand an in vitro or in vivo environment. The present invention includes a blood vessel harvest and carriage cassette ( | 2009-05-14 |
20090123994 | Lockable Signalling Column - The invention relates to a signalling column with levels which are assembled by means of a relative pivoting limited in amplitude and interconnected by means of axially-extending conductors. The body of a level (A) has a locking bar ( | 2009-05-14 |
20090123995 | WASTE TREATMENT SYSTEM - A waste treatment system comprising an impermeable container adapted to accommodate waste, and presenting at least an opening for introducing waste and a plurality of preferential breaking lines for creating respective openings; air-tight closing element of the opening; percolate introduction element within the impermeable container; collector for the formed biogas; a covering layer arranged so as to close the openings; and an air circulation system comprising in turn, within the permeable container a plurality of intake tubes and a plurality of air intakes. | 2009-05-14 |
20090123996 | Vitrification Device with Shape Memory Seal - A closing device to create a seal in a cryocontainer for a biological specimen utilizes the temperature-induced phase transformation of shape memory materials to cause an actuator to toggle between a sealed and unsealed state. The temperature inducement occurs naturally within the normal temperature changes that occur during cryogenic vitrification of biological specimens. | 2009-05-14 |
20090123997 | MODULATORS OF ODORANT RECEPTORS - The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for odorant receptor accessory protein polymorphisms and mutations associated with disease states, as well as methods of screening for therapeutic agents, ligands, and modulators of such proteins. | 2009-05-14 |
20090123998 | Signature encoding sequence for genetic preservation - The present invention describes a method for fabrication of nucleic acid-based medium for storage of socially valuable information. This medium offers the possibility of simple and efficient reproduction of the information and cm be used for preserving information over periods of time, far surpassing those currently achievable by information storage devices utilizing conventional media. | 2009-05-14 |
20090123999 | NUCLEOTIDE SEQUENCES INVOVLED IN PLANT DISEASE RESISTANCE - The present invention relates to methods for producing plants having enhanced disease resistance. NRC1 proteins and nucleic acid sequences encoding these are provided, as well as transgenic plants producing NRC1 proteins. | 2009-05-14 |
20090124000 | Recombinant Vectors - Methods and materials are provided for integrating heterologous nucleic acids into the genome of a cell or virus without disrupting expression of genes adjacent to the insertion site. | 2009-05-14 |
20090124001 | 9-AMINO-ACRIDINE DERIVATIVES AND THEIR USE FOR ELIMINATING MISFOLDED PROTEINS - The invention relates to compounds according to general formula (1) and/or their enantiomers, diastereomers as well as their pharmaceutically compatible salts, and to the use thereof for producing a medicament suited for treating diseases associated with misfolded proteins. | 2009-05-14 |
20090124002 | ALPHA-1D CALCIUM CHANNEL EXPRESSED IN ATRIUM - Novel calcium channel nucleic acids and polypeptides are disclosed herein. Methods of using the novel nucleic acids and polypeptides are also disclosed. | 2009-05-14 |
20090124003 | MODULATORS OF ODORANT RECEPTORS - The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for odorant receptor accessory protein polymorphisms and mutations associated with disease states, as well as methods of screening for therapeutic agents, ligands, and modulators of such proteins. | 2009-05-14 |
20090124004 | Insect desiccation resistance genes and uses thereof - An objective of the present invention is to provide polynucleotides encoding insect desiccation resistance proteins, and uses thereof. cDNA libraries were produced from | 2009-05-14 |
20090124005 | Enhanced Expression and Stability Regions - Expression-enhancing nucleotide sequences for expression in eukaryotic systems are provided that allow for enhanced and stable expression of recombinant proteins in eukaryotic cells. Enhanced expression and stability regions (EESYRs) are provided for expression of a gene of interest in a eukaryotic cell. Chromosomal loci, sequences, and vectors are provided for enhanced and stable expression of genes in eukaryotic cells. | 2009-05-14 |
20090124006 | Serum-Free Culture Medium for the Production of Recombinant Gonadotropins - The present invention is in the field of the manufacture of recombinant proteins. More specifically, it relates to the use of a serum-free culture medium comprising an antioxidant for the production of recombinant dimeric gonadotropins. The antioxidant may be selected from the group consisting of L-glutathione, 2-mercaptoethanol, L-methionine and a combination of ascorbic acid and of (+)-alpha-tocoplierol. | 2009-05-14 |
20090124007 | Method for the Simultaneous Primary-Isolation and Expansion of Endothelial Stem/Progenitor Cell and Mesenchymal Stem Cell Derived From Mammal Including Human Umbilical Cord - Disclosed herein is a method for isolating and culturing the endothelial stem/progenitor cells and mesenchymal stem cells derived from the umbilical cord of mammals, including human beings. More specifically, disclosed are a method for isolating and culturing endothelial stem/progenitor cells and mesenchymal stem cells at high purity from the umbilical cord of mammals, including human beings, and preferably from the human umbilical cord, as well as endothelial stem/progenitor cells and mesenchymal stem cells, isolated and cultured according to said method, and a method for freezing and thawing the isolated and cultured cells. According to the disclosed method, endothelial stem/progenitor cells and mesenchymal stem cells can be easily isolated and purified with high purity from umbilical cord, and can be cultured with high viability for a long period of time. | 2009-05-14 |
20090124008 | PEPTIDES FOR USE IN CULTURE MEDIA - The present invention provides peptides libraries which are useful for rapid identification of biologically active compounds. The invention further provides peptides which include cell-growth affecting peptides and peptides which enhance or inhibit production of cellular proteins. Many of the peptides of the invention may be produced in large quantity by recombinant techniques and formulated in culture medium to produce the desired effect on cultured cells and tissues. Certain of the libraries of the invention and the peptides identified in them are particularly useful in concatemer-based recombinant expression methods. | 2009-05-14 |
20090124009 | ANTISENSE MODULATION OF PTP1B EXPRESSION - Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided. | 2009-05-14 |
20090124010 | Peptide Fractions Promoting Growth and Synthesis of Desired Product (S) Into Cell and/or Tissue Culture - The invention relates to preparing and/or supplementing a cell or tissue culture medium. In particular, said invention relates to a serum-free and/or protein-free cell culture medium comprising peptide fractions isolated from rapeseeds, in particular rapeseeds cakes. A method for the production of a cell culture comprising said peptide fractions and for the use thereof is also disclosed. | 2009-05-14 |
20090124011 | Serum Production System - Bovine serum compositions having controlled bovine serum characteristics and a method of producing such bovine serum compositions having such controlled serum characteristics from the whole blood of an offspring of a female bovine mammal. | 2009-05-14 |
20090124012 | TOXIN/ANTITOXIN SYSTEMS AND METHODS FOR REGULATING CELLULAR GROWTH, METABOLIC ENGINEERING AND PRODUCTION OF RECOMBINANT PROTEINS - The present invention provides compositions and method for regulating cellular growth and metabolism, intra- and extracellular enzymatic activities, and synthesis of endogenous and/or heterologous proteins, comprising the steps of cloning genes encoding an mRNA interferase (toxin) and its cognate antitoxin; expressing these proteins in a host cell from two separate constitutive or inducible promoters on one or more plasmid vectors or on a chromosome; and regulating the cellular growth and metabolism by controlling the ratio of toxin and antitoxin present in the host cell. Optionally, the method provides further steps of modifying an endogenous or heterologous gene of interest to substitute all mRNA recognition sequences with sequences that are not cleavable by the mRNA interferase being expressed without any change in the amino acid sequence of the protein encoded by the gene; and co-expressing the gene of interest in the same host cell. | 2009-05-14 |
20090124013 | Stem-Like Cells - A method for the production and use of multipotential stem-like cells is disclosed. The preparation utilized in this method is characterized by the contact of low level electrical currents with cultures of fibroblasts or other -blast cells enriched by fibroblast growth factor and other nutrients. The electrical current is conducted by means of silver electrode(s) brought into contact with the fibroblast preparation or other -blast cell preparation cultured for that purpose. The cells of the preparation may be used in applications that require the use of stem cells, including therapeutic applications, without the need for human fetuses or human umbilical cords or penetrating human bones to extract bone marrow. The cells thus produced have the ability to redifferentiate into endoderm, ectoderm and mesoderm to form any tissue of the body except the lens of the eye. Any cell found in the blood may be copied and multiplied. Any tissue of the body may be copied and multiplied with the lone exception of the lens of the eye as noted above. | 2009-05-14 |
20090124014 | METHOD FOR HOMOLOGOUS RECOMBINATION IN FUNGAL CELLS - The present invention discloses a method to construct fungal cells having a target sequence in a chromosomal DNA sequence replaced by a desired replacement sequence, comprising: providing a DNA molecule comprising a first DNA fragment comprising a desired replacement sequence flanked at its 5′ and 3′ sides by DNA sequences substantially homologous to sequences of the chromosomal DNA flanking the target sequence and a second DNA fragment comprising an expression cassette comprising a gene encoding diphtheria toxin A and regulatory sequences functional in the fungal cell operably linked thereto; transforming the fungal cells with the resulting DNA molecule; growing the cells to obtain transformed progeny cells having the DNA molecule inserted into the chromosome, wherein cells in which the DNA molecule is inserted in the chromosome via a non-homologous recombination event are selectively killed by expression of diphtheria toxin A; and obtaining cells wherein the target sequence in the chromosomal DNA sequence is replaced by the desired replacement sequence. | 2009-05-14 |
20090124015 | Modular chemistry analyzer - A chemistry analyzer is disclosed that can include a unitary base with vertical and horizontal supports for constraining subassemblies. The subassemblies include at least a reagent/sample carousel subassembly, a transfer arm subassembly, and a reaction carousel subassembly. A centralized hydraulic system can also be provided behind a user access panel. The analyzer can use machine-readable test specifications coupled with its reagent vessels to define tests that include operations that employ the reagents. The analyzer can also display to the operator a pictorial representation that includes graphical elements that convey levels of usage for the storage vessels, and access icons that are each associated with a color and each lead to a set of screens for different types of operations for the analyzer. | 2009-05-14 |
20090124016 | Nanopatterned surfaces and related methods for selective adhesion, sensing and separation - Nanodimensioned heterogeneous surface compositions and configurations, related systems and methods for sensing particle or analyte interaction therewith. | 2009-05-14 |
20090124017 | Sampling Device and Method for the Rapid Detection of Proteins in Mold, Allergens or Other Protein-Containing Substances - Provided is sampling device and method for the detection of protein-containing substances. The sampling device includes a first reagent holder coupled to a second reagent holder by an activating member. Coupled to first reagent holder is a first reagent reservoir and coupled to second reagent holder is a second reagent reservoir. The first reagent reservoir is protected from the ambient environment by a first reagent protector and the second reagent reservoir is similarly protected from the ambient environment by a second reagent protector. After a sample has been obtained from the surface of a sampling object, the application of a sufficient activation force on the activating member places the first reagent reservoir in fluid communication with the second reagent reservoir. | 2009-05-14 |
20090124018 | MIX FOR QUALITY CONTROL OF THE MEDICINE "GLYCINE TABLETS FOR SUBLINGUAL APPLYING O.1G." AND ITS PREPARATION METHOD - The invention relates to the chemical-pharmaceutical industry and specifically to mix for quality control of the medicine “Glycine tablets for sublingual applying 0.1” and its preparation method. The method involves process of analysis by dissolution of 2.5 g of porphyrized tablets in 250 ml of purified water and light transmission spectrophotometer examination at a wave length of 700±2 in a cuvet with layer thickness of 10 mm relative to purified water Process of dissolution takes 20 minutes and is carried out at a temperature of 370° C. in the apparatus for dissolving determination at a paddle rotation speed of 150 rpm. After mix is dissolved it is allowed for 10 minutes then there are selected 4 ml for light transmission analysis. Mix for quality control includes water in a ratio 100:1 to porphyrized tablets, containing in one tablet 0.101 g microcapsules of non-agglomerated crystals of amino-acetic acid covered with polymeric film of water-soluble methylcellulose, MC-100 and 0.001 g of magnesium stearate. Mix light transmission coefficient is within the limits of 50 to 70% in comparison with purified water at a wave length 700±2 nm for 4 ml of mix and with layer thickness of 10 mm. | 2009-05-14 |
20090124019 | ABSOLUTE METHOD FOR THE QUANTIFICATION OF ORGANIC COMPOUNDS - The present invention relates to the quantification of organic compounds originating from a chromatography system that does not involve the use of patterns, comprising the continuous conversion of the carbon of the compounds into carbon dioxide (CO | 2009-05-14 |
20090124020 | Method for Characterizing the Porosity in Fuel Cell Electrodes - A method for evaluating the composition of an MEA for a fuel cell. The method includes soaking the MEA in an unsaturated organic compound for a predetermined period of time, and then allowing the MEA to dry. The method then includes staining the MEA with osmium tetroxide (OsO | 2009-05-14 |
20090124021 | Device for Containing, Reacting and Measuring, and Method of Containing, Reacting and Measuring - The invention relates to a device for containing, reacting and measuring, and a method of containing, reacting and measuring, and provides a device for containing, reacting and measuring, and a method of containing, reacting and measuring which is also able to effectively and quickly perform the reaction processing, measuring and identification. The invention comprises; a transparent container section having a liquid inlet/outlet and which is able to contain a base member with various substances for detection having predetermined chemical structures fixed at respective fixed positions which are arranged in a predetermined condition, and with each of the chemical structures associated with each of the fixed positions, a drawing and discharging section which is able to draw and discharge the liquid into and from the container section via the inlet/outlet, and a measuring device which is able to receive light from the contained base member, external to the container section and in a condition associated with the fixed position. | 2009-05-14 |
20090124022 | ANTIBODIES THAT BIND TO MAMMALIAN NGAL AND USES THEREOF - The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies. | 2009-05-14 |
20090124023 | Reagens for the Detection of Protein Acetylation Signaling Pathways - The invention discloses 432 novel acetylation sites identified in signal transduction proteins and pathways underlying human protein acetylation signaling pathways, and provides acetylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these acetylated sites/proteins, as well as methods of using the reagents for such purpose. Among the acetylation sites identified are sites occurring in the following protein types: Acetyltransferases, Adaptor/Scaffold proteins, Actin binding proteins, Adhesion proteins, Apoptosis proteins, Calcium-binding proteins, Cell Cycle Regulation proteins, Cell Surface proteins, DNA binding proteins, DNA replication proteins, Channel proteins, Chaperone proteins, Cellular Metabolism enzymes, Cytoskeletal proteins, DNA repair proteins, Endoplasmic reticulum proteins, Enzyme proteins, G protein and GTPase Activating proteins, Guanine Nucleotide Exchange Factors, Helicase proteins, Isomerase proteins, Extracelluar matrix proteins, Hydrolases, Ligase proteins, Lipid kinases, Inhibtor proteins, Lipid Binding proteins and Lyases. | 2009-05-14 |
20090124024 | OPTICAL-WAVEGUIDE SENSOR CHIP, METHOD OF MANUFACTURING THE SAME, METHOD OF MEASURING SUBSTANCE, SUBSTANCE-MEASURING KIT AND OPTICAL-WAVEGUIDE SENSOR - An optical-waveguide sensor chip includes an optical waveguide having a first substance immobilized on the surface thereof, the first substance being specifically reactive with an analyte substance, and fine particles dispersed on the optical waveguide and having a second substance immobilized on the surface thereof, the second substance being specifically reactive with the analyte substance. | 2009-05-14 |
20090124025 | Nanowire-based sensor configurations - This invention provides nanowire based molecular sensors and methods for detecting analytes in a microfluidic system. Methods for sensing analytes include detecting changed electrical parameters associated with contact of a nanowire with the analyte in a microfluidic system. Sensors of the invention include nanowires mounted in microchambers of a microfluidic system in electrical contact with the detector, whereby electrical parameter changes induced in the nanowire by the analyte can be monitored by the detector. | 2009-05-14 |
20090124026 | Use of Perfluoropolymer Submicrometric Latexes in the Determination of Molecular Interactions By Laser Light Scattering (Lls) - Use of a latex of perfluorinated polymers having particles with an average diameter between 5 and 200 nm for determining the binding constant of two interacting molecular species by Laser Light Scattering (LLS), said polymeric particles comprising on the surface an amphiphilic non ionic surfactant, the same or a different surfactant ended with a receptor and a ligand interacting with the receptor. | 2009-05-14 |
20090124027 | Structure and Method for Placement, Sizing and Shaping of Dummy Structures - A material layer on a substrate being processed, e.g. to form chips, includes one or more functional structures. In order to control pattern density during fabrication of the chip, dummy fill structures of different sizes and shapes are added to the chip at different distances from the functional structures of the material layer. In particular, the placement, size and shape of the dummy structures are determined as a function of a distance to, and density of, the functional structures of the material layer. | 2009-05-14 |
20090124028 | Imaging device and method for a bonding apparatus - An imaging device and method of a bonding apparatus in which the imaging device includes: a high-magnification optical system having first and second high-magnification optical paths that extend to multiple imaging planes through a high-magnification lens and have different optical path lengths from the high-magnification lens to the respective imaging planes correspondingly to multiple subject imaging ranges which are at different distances from the high-magnification lens; and a low-magnification optical system having a low-magnification optical path that extends to an imaging plane through a low-magnification lens and having a field of view wider than those of the high-magnification optical paths. The imaging elements on the respective imaging planes in the high-magnification optical system are adapted to image semiconductor chips, while the imaging element on the imaging plane in the low-magnification optical system is adapted to image a lead frame. | 2009-05-14 |
20090124029 | METHOD OF FABRICATING RESISTOR AND PROXIMATE DRIVE TRANSISTOR FOR A PRINTHEAD - A method of fabricating a resistor-drive transistor architecture for a printhead of a printer, by depositing printer communication and drive electronics on the printhead. The drive electronics are positioned within a range of one to sixty microns from correlated resistors. | 2009-05-14 |