20th week of 2015 patent applcation highlights part 54 |
Patent application number | Title | Published |
20150133628 | POLYAMINE AND METHOD FOR PRODUCING THEREOF - A method for producing a polyamine is described that provides excellent safety, a lot of flexibility regarding a variety of its productions, and that can produce a polyamine of high-molecular weight easily and inexpensively.
| 2015-05-14 |
20150133629 | DIEPOXY COMPOUND AND METHOD FOR PRODUCING SAME - There is provided a diepoxy compound that can be polymerized to form a cured product having thermal stability that has excellent heat resistance, and can maintain excellent mechanical properties even if exposed to a high temperature environment. The saturated diepoxy compound of the present invention is represented by the following formula (1) and can be produced by hydrogenating the unsaturated bond of an unsaturated diepoxy compound represented by the following formula (2). In the following formulas, R | 2015-05-14 |
20150133630 | Screening Method for Peptide Binding to Target Molecule in PH-Dependent Manner - An object of the present invention is to provide molecules that bind to a target molecule in a pH dependent manner and a screening method for selecting such molecules. Provided is a screening method for selecting peptides that bind to a target molecule at a first pH and do not bind thereto at a second pH, including a step of preparing a peptide library in which each mRNA contains at least one special amino acid that undergoes a pH-dependent change in the charge of the side chain thereof, a step of bringing the peptide library into contact with the target molecule and incubating them under the first pH condition and selecting peptides that bind to the target molecule, and a step of selecting, from the peptides which have bound to the target molecule, peptides that do not bind to the target molecule under the second pH condition. | 2015-05-14 |
20150133631 | Compositions and Methods for Conjugating Oligonucleotides - An oligonucleotide derivative having the structure of formula (A) and methods for preparing the oligonucleotide derivative are disclosed. wherein R | 2015-05-14 |
20150133632 | CONFORMATIONALLY DYNAMIC PEPTIDES - Disclosed are novel peptides that are useful, for example, for detecting target proteins having a β-sheet secondary structure which may be associated with a disease, and for diagnosing and treating such a disease. Related methods and kits also are disclosed. | 2015-05-14 |
20150133633 | MODIFICATION OF PEPTIDES USING A BIS(THIOETHER)ARYLBRIDGE APPROACH - This invention provides novel methods of stabilizing peptides and peptides so stabilized. In certain embodiments the methods involve providing a peptide containing at least two S bearing residues within the peptide; and reacting the peptide with a di-halogen-aryl-compounds to form a bis(thioether)-aryl-bridge between said two residues. | 2015-05-14 |
20150133634 | KIT AND METHOD FOR PRODUCING A RADIOPHARMACEUTICAL - A kit for producing a radiopharmaceutical, having: a cation exchange cartridge; a reaction vial having a marker precursor; a solution vial having a solvent; an elution vial having a sterile solution including common salt (NaCl) and hydrochloric acid (HCl); and a buffer salt. A method for producing a radiopharmaceutical is also disclosed. | 2015-05-14 |
20150133635 | BACTERIAL TOXIN VACCINE - A bacterial toxin protein such as a Shiga toxin protein is efficiently produced using plant cells. The plant cells are transformed using a DNA construct containing DNA encoding a hybrid protein in which the bacterial toxin proteins such as the Shiga toxin proteins are tandemly linked through a peptide having the following characteristics (A) and (B) to produce the bacterial toxin protein in the plant cells: (A) a number of amino acids is 12 to 30; and (B) a content of proline is 20 to 35%. | 2015-05-14 |
20150133636 | Purification of Biological Molecules - The present invention relates to improved processes and systems for purification of biological molecules, where the processes can be performed in a continuous manner. | 2015-05-14 |
20150133637 | P2X7 RECEPTOR ANTAGONISTS AND AGONISTS - The present invention relates to biological materials against P2X7 and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the biological materials of the present invention inhibit the biological activity of the P2X7 receptor, such as activation by ATP. | 2015-05-14 |
20150133638 | SINGLE-CHAIN ANTIBODIES AND OTHER HETEROMULTIMERS - The invention provides engineered heteromultimeric protein complexes constructed using one, two, or three tethers and methods for making, using, and purifying such complexes, such as antibodies with different binding properties. | 2015-05-14 |
20150133639 | Use of Metal Ions for Modulation of Protein Glycosylation Profiles of Recombinant Proteins - Protein glycosylation greatly influences the structure, function, and pharmacokinetics of recombinant proteins. Here, growth media supplemented with metal ions is shown to modulate the protein glycosylation profile of recombinant proteins expressed in a variety of eukaryotic cell lines. In particular, millimolar amounts of ferric salts (e.g. ferric nitrate, ferric citrate, etc.) significantly increased the percentage of galactosylated N-glycan species. The effect on protein glycosylation was concentration-dependent manner up to 1.0 mM across multiple cell lines without adverse effects on cell viability. The use of iron supplements in cell culture media provides an efficient and effective approach towards the specific re-targeting of N-glycan glycoform profiles of recombinantly expressed proteins. | 2015-05-14 |
20150133640 | Production of T cell retargeting hetero-dimeric immunoglobulins - The present invention describes novel hetero-dimeric immunoglobulins or fragments thereof which bind to CD3 and a disease associated antigen. These hetero-dimeric immunoglobulins have been engineered to promote hetero-dimer formation during expression and can be purified to a high degree using a Protein A differential purification technique. | 2015-05-14 |
20150133641 | TRANSGENIC NON-HUMAN VERTEBRATE FOR THE IN VIVO PRODUCTION OF DUAL SPECIFICITY IMMUNOGLOBULINS OR HYPERMUTATED HEAVY CHAIN ONLY IMMUNOGLOBULINS - The invention relates, in one aspect, generally to novel concept of guided selection of antibody variable domains, combination and expression entirely in vivo. An application is to produce multivalent polypeptides. The present invention relates to multivalent (eg, multispecific) antibodies, antibody chains and polypeptides, as well as heavy chain-only antibodies (H2 antibodies) that are devoid of light chains. The invention further relates to the selection, maturation and production of these in vivo in non-human vertebrates and non-human vertebrate cells. To this end the invention also relates to such non-human vertebrates and cells. The invention also relates to the provision of means to produce and select heavy chain-only antibodies and heavy chains comprising variable domains that have undergone affinity maturation. | 2015-05-14 |
20150133642 | CRYSTALLIZATION METHODS FOR PURIFICATION OF MONOCLONAL ANTIBODIES - This application teaches methods for crystallizing antibodies from cell-free culture supernatants. They produce high purity, stable, crystallized monoclonal antibodies suitable for formulation in pharmaceutical products in high yield from cell-free culture supernatant without the use of costly steps or equipment. | 2015-05-14 |
20150133643 | Low Organic Extractable Depth Filter Media Processed with Solvent Extraction Method - Provided is a primary clarification depth filtration process of cell-culture feeds, including chemically treated flocculated feeds, containing target biomolecules of interest such as mAbs, mammalian cell cultures, or bacterial cell cultures, utilizing a primary clarification depth filtration device containing a media with significantly lower flushing requirements, resulting in lower levels of organic extractables released after media flushing, and increased throughput for the pre-treated feed streams, without the use of a primary clarification centrifugation step or primary clarification tangential flow microfiltration step. The primary clarification depth filtration device used in the primary clarification of fluid cell culture feeds, including chemically treated flocculated feeds containing flocculated cellular debris and/or colloidal particulates having a particle size distribution of about 0.5 μm to 200 um, contains a porous depth filter media having porous layers of varying pore ratings, and achieves the desired level, of total organic extractables (1-3 ppm) measured in the feed filtered through the media with, significantly lower flushing requirements. Kits and methods of using and making the same are also provided. | 2015-05-14 |
20150133644 | METHOD TO PRODUCE AN IMMUNOGLOBULIN PREPARATION WITH IMPROVED YIELD - The present invention provides improved methods for the manufacturing of IVIG products. These methods offer various advantages such as reduced loss of IgG during purification and improved quality of final products. In other aspects, the present invention provides aqueous and pharmaceutical compositions suitable for intravenous, subcutaneous, and/or intramuscular administration. In yet other embodiments, the present invention provides methods of treating a disease or condition comprising administration of an IgG composition provided herein. | 2015-05-14 |
20150133645 | Labeled Alginate Conjugates For Molecular Imaging Applications - Described are bifunctional NOTA-based derivatives capable of conjugating with alginate and with metal ions, as well as NOTA-alginate conjugates which can be labeled with stable or radioactive metal ions. Also described are conjugation methods of the bifunctional NOTA-based linker with alginate, and methods of using radiometal-labeled NOTA-alginate conjugates or other radio-labeled alginate conjugates as imaging reagents. | 2015-05-14 |
20150133646 | REDOX-AUXILIARY CATALYSIS - Disclosed herein is a method of activating a compound for a chemical reaction comprising functionalizing a compound with a redox auxiliary group and oxidizing the redox auxiliary group that is bonded to the compound, thereby activating the compound, wherein the activated compound undergoes a chemical reaction to form a product and the oxidation of the redox auxiliary group is reversible. Methods of making and using these materials are also disclosed. | 2015-05-14 |
20150133647 | Method for Producing Oligosaccharides and Oligosaccharide Glycosides by Fermentation - The application discloses a method for producing anomerically protected glycosidic oligosaccharide derivatives comprising the step of culturing, in a culture medium containing an anomerically protected lactose acceptor, a genetically modified cell having a recombinant gene that encodes a glycosyl transferase that can transfer a glycosyl residue of an activated sugar nucleotide to said lactose acceptor. The application further discloses a method for producing an oligosaccharide comprising the steps of: (a) culturing, in a culture medium containing an anomerically protected lactose acceptor, a genetically modified cell having a recombinant gene that encodes a glycosyl transferase that can transfer a glycosyl residue of an activated sugar nucleotide to said lactose acceptor to produce an anomerically protected glycosidic oligosaccharide derivative, then (b) removing/deprotecting the anomeric protective group. | 2015-05-14 |
20150133648 | HYBRID SOLID SUPPORTS USEFUL FOR OLIGONUCLEOTIDE PRODUCTION - A method for preparing a crosslinked polymer coated controlled porosity glass (CPG) particle is provided. The method involves mixing CPG particles in a solution comprising polyvinylbenzylchloride and a first solvent at a temperature below 10° C. A second solvent is added and a crosslinking agent is added to the mixture. The first solvent is removed rapidly within hours of addition of the crosslinking agent. The crosslinking reaction is permitted to proceed and the mixture is then cooled and treated to remove any remaining solvent. The resulting coated CPG particles are washed and dried. Also provided a polymer coated CPG particles using for loading ligand thereon. | 2015-05-14 |
20150133649 | System and Method for Emulsion Breaking - A method of recovering a bead support from an emulsion includes supplying an aqueous surfactant solution into a centrifuge tube; supplying a hydrophobic liquid over the surfactant solution in the centrifuge tube, wherein a ratio of the volume of the aqueous surfactant solution to the volume of the hydrophobic liquid is not greater than 0.5; and applying an emulsion over the hydrophobic liquid while centrifuging, the emulsion comprising a dispersed aqueous phase including the bead support, the emulsion breaking and material of the dispersed phase preferentially partitioning to the surfactant solution. | 2015-05-14 |
20150133650 | DEVICE AND METHOD FOR THE PRODUCTION OF RADIOCHEMICAL COMPOUNDS - The invention relates to a device for the preparation of radiochemical compounds. It is provided that the device comprises at least a reaction module, a dosing module, and a storage module, wherein
| 2015-05-14 |
20150133651 | CslA9 Gluco-mannan Synthase Gene - The invention relates to plants that contain higher proportions of mannans. Such plants express transcription factors that increase the expression of CSLA9, a mannan synthase. | 2015-05-14 |
20150133652 | ACETATIC ABIRATERONE TRIFLUOROACETATE AND PREPARATION METHOD AND APPLICATION OF SAME - Provided are acetaic abiraterone trifluoroacetate, a preparation method and an application of same. The acetaic abiraterone trifluoroacetate is obtained through a salt-forming reaction between acetaic Abiraterone and trifluoroacetic acid. The acetaic abiraterone trifluoroacetate undergoes self-purification through recrystallization, and dissociation and recrystallization are performed on the purified abiraterone acetate trifluoroacetate, so that the obtained acetaic abiraterone has a high purity, a high yield and stable quality, and is capable of meeting the requirement for mass production of acetaic abiraterone. | 2015-05-14 |
20150133653 | COMPOUNDS AND BIOLOGICAL MATERIALS AND USES THEREOF - The invention provides compounds of Formula I: | 2015-05-14 |
20150133654 | NOVEL METHODS AND INTERMEDIATES FOR THE PREPARATION OF (4bS,5aR)-12-CYCLOHEXYL-N-(N,N-DIMETHYLSULFAMOYL)-3-METHOXY-5a-((1R,5S)-3- -METHYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBONYL)-4b,5,5a,6-TETRAHYDROBENZ- O [3,4]CYCLOPROPA[5,6]AZEPINO[1,2-A]INDOLE-9-CARBOXAMIDE - The present invention provides methods and intermediates for the preparation of (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide (formula I), including pharmaceutically acceptable salts. The compound has activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV. | 2015-05-14 |
20150133655 | METHODS AND COMPOSITIONS FOR PREPARING NORIBOGAINE FROM VOACANGINE - Disclosed are methods and compositions for preparing and purifying the non-addictive alkaloid noribogaine. | 2015-05-14 |
20150133656 | NOVEL BICYCLIC THIAZOLE COMPOUNDS - The present invention relates to novel bicyclic thiazole compounds that inhibit Traf2- and Nck-interacting kinase (TNIK), and as such are useful as TNIK inhibitors administered to cancer patients, especially to solid cancer patients such as colorectal cancer, pancreatic cancer, non-small cell lung cancer, prostate cancer or breast cancer. The bicyclic thiazole compounds are showed by a next formula (I). (wherein R | 2015-05-14 |
20150133657 | PROCESS FOR THE PREPARATION OF RIVAROXABAN - The present invention provides processes for the preparation of rivaroxaban. The present invention also provides an intermediate for the preparation of rivaroxaban. | 2015-05-14 |
20150133658 | NEPRILYSIN INHIBITORS - In one aspect, the invention relates to compounds having the formula: | 2015-05-14 |
20150133659 | (E)-1-(5-METHOXY-2,2-DIMETHYL-2H-CHROMEN-8-YL)-3-(4-METHOXYPHENYL)PROP-2-E- N-1-ONE AND ANALOGS THEREOF, AS WELL AS PREPARATION METHOD AND USE THEREOF - The present invention relates to millepachine ((E)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one) and its analogues. The present invention provides methods for preparing these compounds, pharmaceutical compositions including these compounds, and methods of treating diseases utilizing pharmaceutical compositions including these compounds. | 2015-05-14 |
20150133660 | METHOD FOR PRODUCING N-SULFONYL-SUBSTITUTED OXINDOLES - Process for the selective N-sulfonylation of oxindoles, in particular process for the N-sulfonylation of 3-triazinyloxindoles, and also N-sulfonyl-substituted 3-triazinyl-oxindoles and the use of N-sulfonyl-substituted oxindoles and of N-sulfonyl-substituted 3-triazinyloxindoles as intermediates for the synthesis of fine chemicals and of active ingredients in the field of pharmacy and agriculture, and also the use of these compounds as active ingredients in the field of agriculture. | 2015-05-14 |
20150133661 | INHIBITORS OF BRUTON'S TYROSINE KINASE - Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate irreversible inhibitor of a protein, including a kinase. | 2015-05-14 |
20150133662 | NOVEL ORGANIC ELECTROLUMINESCENCE COMPOUNDS AND ORGANIC ELECTROLUMINESCENCE DEVICE CONTAINING THE SAME - The present invention relates to novel organic electroluminescent compounds and an organic electroluminescent device comprising the same. The organic electroluminescent compounds according to the present invention have high luminescent efficiency and a long lifespan, and thus an organic electroluminescent device having a long operating lifespan can be prepared by using the organic electroluminescent compounds according to the present invention. | 2015-05-14 |
20150133663 | NOVEL SYNTHESIS METHOD - The present invention relates to a method of making compounds having affinity for the 1 A subtype of the serotonin receptor, i.e. 5HT | 2015-05-14 |
20150133664 | CHEMICAL TRANSFORMATIONS OF (-)-CODEINE TO AFFORD DERIVATIVES OF CODEINE AND MORPHINE THEREOF - The present invention relates to methods for the synthesis of morphine, codeine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency, steroselectivity, and overall yield of said codeine and morphine related derivatives and intermediates thereof. The present invention relates to new codeine and morphine related derivative compositions. | 2015-05-14 |
20150133665 | PROCESSES AND INTERMEDIATES IN THE PREPARATION OF MORPHINE ANALOGS VIA N-DEMETHYLATION OF N-OXIDES USING CYCLODEHYDRATION REAGENTS - A high-yielding method for the N-demethylation of oxycodone- and oxymorphone-N-oxides by the reaction of these compounds with cyclodehydration reagents has been performed. This method has been utilized to improve the synthesis of various morphine analogs, such as naltrexone, nalbuphone and naloxone. | 2015-05-14 |
20150133666 | TRITOQUALINE FOR USE IN THE TREATMENT OF CYSTIC FIBROSIS - The present invention relates to the use of a histamine H4 agonist molecule, the enantiomers of the (AMINO-7 TRIETHOXY-4,5,6 OXO-1 DIHYDRO-1,3 ISOBENZOFURANNYL-3)-1METHOXY-8 METHYL-2 METHYLENEDIOXY-6,7 TETRAHYDRO-,2,3,4 ISOQUINOLINE or tritoqualine for the treatment of respiratory impairment caused by cystic fibrosis and the reduction and prevention of bronchial superinfections. | 2015-05-14 |
20150133667 | PROCESS FOR THE PREPARATION OF METHYLPHENIDATE AND PHARMACEUTICAL SALTS THEREOF - The present invention is directed to an improved process for the preparation of methylphenidate, stereoisomer, mixture of stereoisomers and pharmaceutically acceptable salts thereof, more particularly, the sulfate and hydrochloride salts of methylphenidate, di-threo-methylphenidate and dex-methylphenidate. Methods of removing or reducing the amount of impurities from the above described process are also disclosed. | 2015-05-14 |
20150133668 | PROCESS FOR THE PREPARATION OF METHYLPHENIDATE AND PHARMACEUTICAL SALTS THEREOF - The present invention is directed to an improved process for the preparation of methylphenidate, stereoisomer, mixture of stereoisomers and pharmaceutically acceptable salts thereof, more particularly, the sulfate and hydrochloride salts of methylphenidate, di-threo-methylphenidate and dex-methylphenidate. Methods of removing or reducing the amount of impurities from the above described process are also disclosed. | 2015-05-14 |
20150133669 | NEW PROCESS FOR THE PREPARATION OF 2-CYCLOPENTYL-6-METHOXY-ISONICOTINIC ACID - The present invention relates to new processes for the preparation of 2-cyclopentyl-6-methoxy-isonicotinic acid, which is a useful intermediate for the synthesis of pyridine-4-yl derivatives as immunomodulating agent. Moreover, the present invention also relates to new intermediates used in those processes. | 2015-05-14 |
20150133670 | PROCESS FOR SORAFENIB TOSYLATE POLYMORPH III - The present invention provides a novel process for the preparation of sorafenib tosylate polymorph III. | 2015-05-14 |
20150133671 | The Process For Preparing a Ketosulfone Derivative - The present invention relates to a process for preparing a ketosulfone derivative and, more particularly, to an improved method for synthesising 1-(6-methylpyridin-3-yl)-2-[(4-methylsulfonyl)-phenyl]ethanone by means of Pd-catalysed alpha arylation process of a heteroaromatic ketone derivative. | 2015-05-14 |
20150133672 | PROCESS FOR FLUORINATING COMPOUNDS - Methods of preparing a fluorinated aryl or heteroaryl substrate by combining a quaternary ammonium cyanide and an aryl or heteroaryl substrate substituted with at least one chloro, bromo, sulfonyl, or nitro group to thereby provide a mixture, and combining the mixture with hexafluorobenzene to thereby provide the fluorinated substrate. | 2015-05-14 |
20150133673 | PROCESS FOR FLUORINATING COMPOUNDS - Methods of preparing a fluorinated substrate by combining potassium fluoride, imidazolium salt, and a substrate substituted with at least one chloro, bromo, sulfonyl, or nitro group to thereby provide the fluorinated substrate are disclosed. | 2015-05-14 |
20150133674 | PROCESS FOR THE SYNTHESIS OF AN INDOLEAMINE 2,3-DIOXYGENASE INHIBITOR - The present application is directed to processes and intermediates for making 4-({2-[(aminosulfonyl)amino]ethyl}amino)-N-(3-bromo-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide, which is an inhibitor of indoleamine 2,3-dioxygenase, useful in the treatment of cancer and other disorders. | 2015-05-14 |
20150133675 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS - Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette's syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. Pharmaceutically acceptable salts, stereoisomers, solvates and prodrugs of the compounds are also provided. Also disclosed are compositions containing a compound in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting PDE10 in a warm-blooded animal in need of the same. | 2015-05-14 |
20150133676 | Process for Preparing Disubstituted Urea and Carbamate Compounds from Amines, Carbon Dioxide, and Epoxides - The present disclosure relates to a method for preparing a disubstituted urea and carbamate compounds simultaneously through a one-pot reaction of an amine, carbon dioxide and an alkylene oxide compound in the presence of an ionic liquid-based complex catalyst system containing indium. In accordance with the present disclosure, a disubstituted urea and carbamate compounds can be prepared simultaneously at high yield. In addition, the ionic liquid-based catalyst containing indium according to the present disclosure is economical because it can be reused several times. | 2015-05-14 |
20150133677 | SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'-INDOLIN]-2'-ONES - The present invention is directed to novel synthetic methods for preparing a spiro cyclopropyl indolinone compound represented by Structural Formula (A): | 2015-05-14 |
20150133678 | ORGANIC COMPOUNDS CONTAINING SQUARIC ACID OR CROCONIC ACID MOIETIES FOR APPLICATION IN ELECTRONIC DEVICES - A compound containing a squaric acid or a croconic acid group as an anchoring group. The compound containing a squaric acid or a croconic acid group has formula 1: | 2015-05-14 |
20150133679 | ASYMMETRIC FUSED POLYHETEROAROMATIC COMPOUND, ORGANIC THIN FILM INCLUDING THE ASYMMETRIC FUSED POLYHETEROAROMATIC COMPOUND, AND ELECTRONIC DEVICE INCLUDING THE ORGANIC THIN FILM - An asymmetric fused polycyclic heteroaromatic compound is represented by the above Chemical Formula 1-1 or Chemical Formula 1-2, and is highly fused due to fusion of greater than or equal to 4 rings. | 2015-05-14 |
20150133680 | DIRECT ANTI-MARKOVNIKOV ADDITION OF ACIDS TO ALKENES - A method of making an anti-Markovnikov addition product is carried out by reacting an acid with an alkene or alkyne in a dual catalyst reaction system to the exclusion of oxygen to produce said anti-Markovnikov addition product; the dual catalyst reaction system comprising a single electron oxidation catalyst in combination with a hydrogen atom donor catalyst. Compositions useful for carrying out such methods are also described. | 2015-05-14 |
20150133681 | METHODS OF PURIFYING AND IDENTIFYING THE PRESENCE OF AND LEVELS OF PROCYANIDIN OLIGOMERIC COMPOUNDS - The invention provides methods of purifying and quantifying procyanidin oligomers from cocoa-containing sources. The methods advantageously provide ways to isolate commercially useful quantities of a range of procyanidin oligomers. | 2015-05-14 |
20150133682 | PREPARATION OF ISOCYANATO SILANES - A process for the preparation of alkoxysilyl group-containing isocyanate compounds which includes the step of reacting carbonyl chloride ClC(═O)Cl with an alkoxysilyl group-containing amine in the presence of a high boiling point base, and optionally in the presence of an inert organic solvent, in order to minimize by product production and to simplify product purification, is disclosed. | 2015-05-14 |
20150133683 | Production of Terephthalic Acid Di-Esters Using Alcohol-Amine Promoters - The invention is directed to a process for preparing a terephthalic acid di-ester. The process includes contacting terephthalic acid with a C | 2015-05-14 |
20150133684 | METHODS OF MAKING L-ORNITHINE PHENYL ACETATE - Disclosed herein are processes for making L-ornithine phenyl acetate. The process may include, for example, intermixing a halide salt of L-ornithine with silver phenyl acetate. The process may also include forming a phenyl acetate salt in situ. The present application also relates to various compositions obtained from these processes, including crystalline forms. | 2015-05-14 |
20150133685 | PROCESS TO PRODUCE A DIENE FROM A LACTONE - The invention provides a process for the production of a diene. In the process, a lactone is heated in the presence of a first catalyst system to produce an alkene and carbon dioxide and the alkene is contacted with a second catalyst system to produce an alkyldiene. | 2015-05-14 |
20150133686 | MECHANICALLY STABLE HOLLOW CYLINDRICAL SHAPED CATALYST BODIES FOR GAS PHASE OXIDATION OF AN ALKENE TO AN UNSATURATED ALDEHYDE AND/OR AN UNSATURATED CARBOXYLIC ACID - A hollow cylindrical shaped catalyst body for gas phase oxidation of an alkene to an α,β-unsaturated aldehyde and/or an α,β-unsaturated carboxylic acid comprises a compacted multimetal oxide having an external diameter ED, an internal diameter ID and a height H, wherein ED is in the range from 3.5 to 4.5 mm; the ratio q=ID/ED is in the range from 0.4 to 0.55; and the ratio p=H/ED is in the range from 0.5 to 1. The shaped catalyst body is mechanically stable and catalyzes the partial oxidation of an alkene to the products of value with high selectivity. It provides a sufficiently high catalyst mass density of the catalyst bed and good long-term stability with acceptable pressure drop. | 2015-05-14 |
20150133687 | PROCESS FOR PREPARING AN UNSATURATED ALDEHYDE AND/OR AN UNSATURATED CARBOXYLIC ACID - An α,β-unsaturated aldehyde and/or an α,β-unsaturated carboxylic acid are prepared by gas phase oxidation of alkene with molecular oxygen over a fixed catalyst bed comprising a bed of hollow cylindrical shaped catalyst bodies having a multimetal oxide active composition. The fixed catalyst bed comprises at least three successive reaction zones; the highest local temperature in the fixed catalyst bed does not occur in the reaction zone closest to the reactor outlet; the highest local temperature in the fixed catalyst bed does not occur in the reaction zone closest to the reactor inlet; and the value WT=(ED−ID)/2 in the reaction zone in which the highest local temperature in the fixed catalyst bed occurs is lower than in the other reaction zones, in which ED is the external diameter and ID is the internal diameter of the shaped catalyst body. The yield of the products of value is enhanced in this way. | 2015-05-14 |
20150133688 | BIFUNCTIONAL COMPOUNDS USEFUL AS LIGANDS OF URANIUM (VI), METHODS OF SYNTHESISING SAME AND USES THEREOF - New compounds which meet general formula (I): | 2015-05-14 |
20150133689 | UREA GRANULATION PROCESS WITH SCRUBBING SYSTEM - Disclosed is a method for producing granular urea and reducing ammonia emissions in a gaseous waste stream of the urea granulation process. The method includes the steps of granulating urea and generating a gaseous waste stream from the granulation of the urea, first washing the waste stream in a first scrubber dust stage to remove dust form the gaseous waste stream, and then reacting the gaseous waste stream with formaldehyde in a formaldehyde stage to generate a hexamethylenetetramine and urea-formaldehyde liquid stream, and an ammonia-reduced off-gas stream. | 2015-05-14 |
20150133690 | UREA PRODUCTION PLANT - Disclosed is a plant for the production of urea. The plant comprises conventional sections for synthesis and recovery, for evaporation and condensation, for urea finishing, and for dust scrubbing. According to the invention, an additional evaporation and condensation loop is introduced from and to the dust scrubbing section. This loop results in a more favorable energy consumption of the plant. | 2015-05-14 |
20150133691 | RECOVERY METHOD AND RECYCLING METHOD FOR BORON TRIFLUORIDE COMPLEX - In a reaction in which a boron trifluoride complex is used as a catalyst, the expensive and harmful boron trifluoride complex is separated from a reaction mixture containing the boron trifluoride complex by separating the boron trifluoride complex present in the reaction mixture by using a saturated hydrocarbon-based solvent. | 2015-05-14 |
20150133692 | METHOD FOR PRODUCING POLYTHIOL COMPOUND, POLYMERIZABLE COMPOSITION FOR OPTICAL MATERIAL, AND USES THEREOF - Provided is a method for producing a polythiol compound, comprising: a step for reacting 2-mercaptoethanol with a defined epihalohydrin compound at a temperature of 10° C. to 50° C. to obtain a defined polyalcohol compound; a step for reacting the polyalcohol compound thus obtained with thiourea in the presence of hydrogen chloride to obtain an isothiuronium salt; a step for adding, while maintaining a reaction solution containing the isothiuronium salt thus obtained at a temperature of 15° C. to 60° C., aqueous ammonia to the reaction solution within 80 minutes, thereby hydrolyzing the isothiuronium salt to obtain a defined polythiol compound; and a step for adding hydrochloric acid which is a concentration of 25% to 36% to the solution containing the polythiol compound thus obtained, washing the solution at a temperature of 10° C. to 50° C. to purify the polythiol compound. | 2015-05-14 |
20150133693 | METHODS OF CONVERTING MIXTURES OF PALMITOLEIC AND OLEIC ACID ESTERS TO HIGH VALUE PRODUCTS - The invention describes methods and systems for making particular organic compounds from unsaturated fatty acids derived from biological materials. Particular embodiments describe synthesizing civetone and olefins from a mixture of palmitoleic and oleic unsaturated fatty acid esters. The inventive methods use reaction steps such as metathesis, cyclization, hydrolysis, and/or decarboxylation. | 2015-05-14 |
20150133694 | GREEN PROCESS FOR PRODUCING 3-METHYL-3-PENTENE-2-ONE - The present invention relates to an improved and sustainable process for producing 3-methyl-3-pentene-2-one which is used in the synthesis of fragrance ingredients for perfumery applications. | 2015-05-14 |
20150133695 | HYDROFORMYLATION PROCESS - A process comprising contacting a reaction fluid, which contains at least one phosphorus acidic compound, with a buffer solution to neutralize at least some amount of the phosphorus acidic compound, wherein the buffer solution comprises at least one salt of an unsaturated aliphatic carboxylic acid. | 2015-05-14 |
20150133696 | Process for the Production of Polyether Polyols - A method to provide polyether polyols comprises the steps of •providing a crude polyether polyol mixture comprising polyether polyol and a base catalyst; •neutralizing said base catalyst; •removing, in a first dehydration step, at least part of the water from the neutralized polyether polyol; •redissolving at least part of the salt crystals obtained by removal of at least part of the water; •removing, in a second dehydration step, at least part of the water from the neutralized polyether polyol mixture, thereby providing salt crystals; •removing the salt crystals from the neutralized polyether polyol, thereby providing the polyether polyol mixture. | 2015-05-14 |
20150133697 | METHOD FOR PRODUCING GLYCOLS FROM OXIRANE COMPOUND - There is provided a method for producing dipropylene glycol (DPG) and/or tripropylene glycol (TPG) including: (A) reacting a raw material liquid including propylene oxide and water to obtain a reaction liquid including unreacted water, propylene glycol (PG), DPG and/or TPG, and an alcohol compound excluding PG, DPG, and TPG; (B) separating, from the reaction liquid, a first liquid containing water and the alcohol compound and a second liquid containing the PG, DPG and/or TPG and optionally the alcohol compound; (C) removing a part of the alcohol compound from the first liquid to obtain a third liquid containing water and optionally a part of the alcohol compound; (D) separating, from the second liquid, a fourth liquid containing the PG and optionally the alcohol compound, and a fifth liquid containing the DPG and/or TPG and optionally the alcohol compound; and (E) recycling a part of the third liquid to step (A). | 2015-05-14 |
20150133698 | PRODUCTION OF FATTY ALCOHOLS FROM ENGINEERED MICROORGANISMS - The invention generally relates to the production of a fatty alcohol composition from recombinant microbial cells. The fatty alcohols are produced by expressing a gene encoding a heterologous fatty alcohol forming acyl-CoA reductase (“FAR”); a gene encoding a heterologous thioesterase (“TE”) gene and a gene encoding an acyl-CoA synthetase (“ACS”). | 2015-05-14 |
20150133699 | PROCESS FOR THE PREPARATION OF METHANOL AND METHANOL-DERIVED PRODUCTS FROM CARBON OXIDES - A process for the preparation of methanol having the process a carbon oxides per-pass conversion equal to or higher than 65%, and a selectivity to methanol formation equal to or higher than 75% by submitting carbon dioxide, carbon monoxide or a mixture of carbon monoxide and carbon dioxide to a hydrogenation reaction using a specific metal compound and specific reaction conditions of temperature, pressure, space velocity and a specific range of molar ratio of hydrogen to carbon dioxide, of hydrogen to carbon monoxide, or of hydrogen to the mixture of carbon monoxide and carbon dioxide. It further relates to a process for converting the methanol obtained into dimethyl ether or into a mixture of (C | 2015-05-14 |
20150133700 | Process for Producing Ethanol by Hydrogenation with Carbon Monoxide Controls - A process for produce ethanol by hydrogenation acetic acid and/or esters thereof is disclosed. The process involves reacting hydrogen feed stream with an acetic acid feed stream in a reactor operated in the presence of a catalyst to form an ethanol mixture and monitoring carbon monoxide concentration of the fresh hydrogen feed stream and adjusting temperature in the reactor in response to the carbon monoxide concentration of the fresh hydrogen feed stream. | 2015-05-14 |
20150133701 | Integrated Steam Methane Reformer and Hydrogenation of Acetic Acid to Produce Ethanol - A process is disclosed for integrating a steam methane reformer to produce hydrogen that is used for converting acetic acid and/or ethyl acetate to ethanol. The process may use a methane-containing stream obtained from a stranded natural gas or associated gas source. The process water from the hydrogenation reaction is used to saturate the methane-containing stream. The process water comprises water and oxygenates, wherein the maximum amount of oxygenates is less than or equal to 10 wt. %. Processes for integrating fuel sources, steam and electricity are also disclosed. | 2015-05-14 |
20150133702 | EMISSIONS CONTROL OF SPENT AIR FROM CUMENE OXIDATION - Methods and systems for removing volatile organic compounds from spent air are provided. The method can include oxidizing cumene in the presence of an oxidant to produce an oxidized product containing methanol and a spent air, separating the spent air from the oxidized product, contacting the spent air with an absorbent, an adsorbent, or a mixture thereof to remove at least a portion of any impurities in the spent air to produce a first purified air, and contacting the first purified air with a biological material to produce a treated air. | 2015-05-14 |
20150133703 | Method Of Making Oxygenates From A Non-Catalytic Chemical Reaction - A system and a method for forming oxygenates from a non-catalytic reaction. A hydrocarbon gas and an oxygen-containing gas are fed into a mixer and then heated to form a reactant gas stream. The reactant gas stream is fed into a fluidized bed reactor where the reaction of the gases occurs by oxidization to produce oxygenates. The oxygenate products are then removed from the reactor. | 2015-05-14 |
20150133704 | PROCESS FOR PRODUCING HYDROCARBONS - A process for converting biomass to products is described. Biomass is contacted with hydrogen in the presence of a fluidized bed of hydropyrolysis catalyst in a reactor vessel under hydropyrolysis conditions; and products and char are removed from the reactor vessel. The products leave the fluidized bed at an exit bed velocity, the char has a settling velocity that is less than the exit bed velocity and hydropyrolysis catalyst has a settling velocity that is greater than the exit bed velocity. | 2015-05-14 |
20150133705 | DEHYDROGENATION OF ALKANOLS TO INCREASE YIELD OF AROMATICS - The present invention provides methods, reactor systems, and catalysts for increasing the yield of aromatic hydrocarbons produced while converting alkanols to hydrocarbons. The invention includes methods of using catalysts to increase the yield of benzene, toluene, and mixed xylenes in the hydrocarbon product. | 2015-05-14 |
20150133706 | METHODS OF PRODUCING JET FUEL FROM NATURAL OIL FEEDSTOCKS THROUGH OXYGEN-CLEAVED REACTIONS - Methods are provided for producing a jet fuel composition from a feedstock comprising a natural oil. The methods comprise reacting the feedstock with oxygen under conditions sufficient to form an oxygen-cleaved product. The methods further comprise hydrogenating the oxygen-cleaved product under conditions sufficient to form a jet fuel composition. | 2015-05-14 |
20150133707 | SEPARATION OF COMPONENTS FROM A MULTI-COMPONENT HYDROCARBON STREAM - A process ( | 2015-05-14 |
20150133708 | AN APPARATUS FOR PRODUCING ETHYLENE AND A PRODUCING METHOD THEREOF - An apparatus for producing ethylene includes: a reactor; a first separation column, connected to the reactor; a second separation column, the upper part of the second separation column being connected to the bottom of the first separation column, and the top of the second separation column being connected to the lower part of the first separation column; a first condenser, an inlet of the first condenser being connected to the top of the first separation column, and an outlet of the first condenser being connected to the upper part of the first separation column; and a third separation column, used for receiving a second part of a first condensate from the condenser and separating the received part. A method for producing ethylene using the aforementioned apparatus is also described. | 2015-05-14 |
20150133709 | LOW NOx BURNER FOR ETHYLENE CRACKING FURNACES AND OTHER HEATING APPLICATIONS - A burner assembly for and method of producing ethylene having a mechanism to inject either primary fuel, staged fuel, or both by premix methods before combustion in a furnace. The burner assembly has at least one premix injection assembly for either exclusively primary fuel or exclusively staged fuel injection paired with a nozzle mix injection or injection means for primary and staged fuel both by premix methods. The primary fuel premix assembly associates with a burner tile that consists of multiple inlets and outlets connected by venturi channels to direct and combine combustion air and staged fuel coming from staged fuel orifice spuds. Primary fuel and combustion air are mixed in a premix assembly and directed inside the furnace, and above the burner tile to complete the reaction with the staged fuel and combustion air mixture in a combustion zone inside of the furnace. | 2015-05-14 |
20150133710 | FLUID CATALYTIC CRACKING SYSTEM AND PROCESS - One exemplary embodiment can be a fluid catalytic cracking system. The system can include a reaction zone, in turn including a reactor receiving, a fluidizing stream, a fuel gas stream, a fluidizable catalyst, a stream having an effective amount of oxygen for combusting the fuel gas stream, and a feed. | 2015-05-14 |
20150133711 | Separations With Ionic Liquid Solvents - Disclosed are systems and methods which provide a process stream comprising a gaseous component, capture the gaseous component from the process stream by an ionic liquid solvent of a separator, and recover a captured gaseous component from the ionic liquid solvent in a regenerator. A second gaseous component from the process stream may be captured by the ionic liquid solvent of the separator, and the second gaseous component may be recovered from the ionic liquid solvent in the regenerator. Alternatively, the second gaseous component from the process stream may be uncaptured by the ionic liquid solvent, and the uncaptured second gaseous component may be recovered from a membrane unit. | 2015-05-14 |
20150133712 | PROCESS FOR THE ISOLATION OF CAROTENOIDS - Described herein is a material for reversibly binding to a carotenoid comprising a support coupled to silver ions in an amount to enable reversible binding with carotenoids, and wherein with the exception of silver ions, is substantially free of transition metals. Also described herein is a process for reversibly binding a carotenoid, the process comprising the steps of: providing a support coupled to silver ions in an amount to enable reversible binding with the carotenoid, wherein with the exception of silver, the support is substantially free of transition metals, contacting the support with the carotenoid under binding conditions to bind it thereto and dissociating the carotenoidod from the support under dissociating conditions to release the carotenoid. | 2015-05-14 |
20150133713 | Method For Compensating The Deviation Of A Hadron Beam Produced By A Hadron-Therapy Installation - The present invention relates to a method for compensating the deviation of an energetic beam of hadrons delivered by an irradiation unit of a hadron-therapy installation, with respect to an isocentre of a rotatable gantry supporting said irradiation unit, said irradiation unit comprising a collimator comprising an opening for the passage of said beam. The present invention also relates to a program comprising an algorithm for calculation of a correction to be applied to the position of an opening of a collimator of an irradiation unit of a hadron-therapy installation. The invention finally also relates to a hadron therapy installation. | 2015-05-14 |
20150133714 | IRRADIATION PLANNING APPARATUS AND CHARGED PARTICLE IRRADIATION SYSTEM - A planning apparatus ( | 2015-05-14 |
20150133715 | PARTICLE BEAM IRRADIATION APPARATUS AND PARTICLE BEAM THERAPY SYSTEM - When IMRT technology for a radiation therapy system utilizing an X-ray or the like is applied to a particle beam therapy system having a conventional wobbler system, it is required to utilize two or more boluses. The present invention solves the problem of excess irradiation in IMRT by a particle beam therapy system. More specifically, the problem of excess irradiation in IMRT by a particle beam therapy system is solved by raising the irradiation flexibility in the depth direction, without utilizing a bolus. A particle beam irradiation apparatus has a scanning irradiation system that performs scanning with a charged particle beam accelerated by an accelerator and is mounted in a rotating gantry for rotating the irradiation direction of the charged particle beam. The particle beam irradiation apparatus comprises a columnar-irradiation-field generation apparatus that generates a columnar irradiation field by enlarging the Bragg peak of the charged particle beam. | 2015-05-14 |
20150133716 | Hearing devices based on the plasticity of the brain - The invention describes a hearing improvement device including components for training the brain to connect and stimulate the auditory and visual corteces and strengthen pathways between them, in order to overcome the shortcomings of the damaged auditory channel. | 2015-05-14 |
20150133717 | Monitoring and Detecting Magnetic Stimulation - A method, system, and apparatus for monitoring a magnetic field related to magnetic stimulation may be provided. A system for monitoring a pulsing magnetic field related to magnetic stimulation therapy may include a magnetic stimulation component, a sensor, and a processor. The magnetic stimulation component may be configured to generate the pulsing magnetic field for the magnetic stimulation therapy. The sensor may be configured to generate a signal associated with the pulsing magnetic field. The processor may be configured to estimate a first characteristic associated with a first peak of the signal, estimate a second characteristic associated with a second peak of the signal, and determine a third characteristic of the signal based on the first characteristic and the second characteristic. The processor may be configured to determine whether a failure occurred based on the third characteristic of the signal. | 2015-05-14 |
20150133718 | HINGED TRANSCRANIAL MAGNETIC STIMULATION ARRAY FOR NOVEL COIL ALIGNMENT - Adjustable devices and methods of adjusting and customizing Transcranial Magnetic Stimulation (TMS) electromagnets to produce an elongated path of induced electrical current along a user-defined trajectory in patients having a variety of different head shapes and curvatures. Existing TMS electromagnets (“coils”) allow only limited adjustment of the current delivery surfaces. The present invention provides means for adjusting the sub-coil loops within a double coil structure. The present design may be powered with the use of a single TMS pulse generator unit. | 2015-05-14 |
20150133719 | MODULAR IMPLANTABLE MEDICAL PUMP - An implantable medical pump system can include a blood pump comprising a pump housing defining a passage therethrough and a rotor within the passage. The blood pump further includes one or more elements at least partially contained within the housing adapted to actuate the rotor to drive fluid though the passage. The pump housing includes at least one coupling feature. The system further includes an inflow cannula defining a lumen therethrough. The inflow cannula is adapted to be mechanically coupled to the at least one coupling feature. | 2015-05-14 |
20150133720 | BIFURCATED OUTFLOW CANNULAE - A bifurcated cannula for directing blood into the arterial system. The bifurcated cannula including an ingress channel and first and second egress channels. The first egress channel directs a first portion of the blood entering the bifurcated cannula into the arterial system in a first direction. The second egress channel directs a second portion of the blood entering the bifurcated cannula into the arterial system in a direction that opposes the first direction. | 2015-05-14 |
20150133721 | HEART ASSIST APPARATUS AND METHOD OF USE THEREOF - The invention comprises a heart assist device. In one embodiment, the heart assist device comprises a compressible sleeve about a body part, where one or more portions of the sleeve compress to provide a force on blood generating a flow or pulse of blood in the human circulatory system. In one case, the sleeve is external to the body, such as circumferentially about a limb or about a body extremity. In another case, the sleeve is internal to the body, such as circumferentially about an artery or vein. In still another case, two or more sleeves cooperatively function in parallel and/or in series. The heart assist device is optionally configured to auto-start in an emergency system, is in on-demand or in continuous contact with an emergency response system, and/or is linked to a medical professional's system. | 2015-05-14 |
20150133722 | PULSATILE BLOOD PUMP - An extravascular pulsation blood pump possesses a bidirectionally acting pumping system (P, M) having a pump (P) which is connected via a first conduit (L | 2015-05-14 |
20150133723 | VENTRICULAR ASSIST DEVICE AND RELATED METHODS - A method and system are provided for percutaneously gaining access to oxygenated blood with one or more anastomosis devices and pumping such oxygenated blood directly to the aorta adjacent to the right atrium or left atrium via a VAD system. In one embodiment, a VAD system can be implanted with open surgery. | 2015-05-14 |
20150133724 | PERINEAL PROBE - Provided is a perineal probe including a substantially cylindrical support rod in an insulating material, defining an axial direction and a circumferential direction, an end portion, constituting the inner end of said support rod, a grip for said perineal probe positioned on the support rod at the opposite end of said end portion, four electrodes positioned on the outer surface of the support rod, wherein each electrode extends for a circumferential portion ranging from 60° to 180°, wherein the electrodes are two by two aligned in an axial direction and reciprocally distanced in a circumferential direction, are in addition two by two aligned in a circumferential direction and distanced in an axial direction, and wherein each electrode is connected to a different electric output. | 2015-05-14 |
20150133726 | Stabilizer for the Transvaginal Placement of a Midurethral Sling - A sling for stress urinary incontinence (SUI) may be placed and stabilized using a midurethral sling stabilizer. First, a sling may be placed beneath the urethra in a position to support the urethra, without tension. The midurethral sling stabilizer may then be inserted in a manner where the distal end partially encompasses and stabilizes the sling through a partial aperture and stabilizes the sling in a desired position, without tension. Once the sling is stabilized in the desired position, the sheath may be removed from the sling. | 2015-05-14 |
20150133727 | APPARATUS AND METHODS FOR ACCESSING AND SEALING BODILY VESSELS AND CAVITIES - Everting balloon systems and methods for using the same are disclosed herein. The systems can be configured to access and dilate body lumen and cavities. For example, the systems can be used to dilate the cervix and access the uterine cavity. The systems can also be used to occlude the cervix. The systems can also be used to occlude the urethra. | 2015-05-14 |
20150133728 | AIMING BEAM DETECTION FOR SAFE LASER LITHOTRIPSY - Medical apparatus includes an endoscope, which includes a distal end configured for insertion into a body cavity and which includes an imaging assembly, configured to capture and output an image of a region of the body cavity in proximity to the distal end. An energy source is configured to emit pulses of energy through an energy guide. A control unit is configured to process the image so as to identify a target mass in the body cavity and to verify that an aiming beam directed through the energy guide is incident on the target mass and, responsively to so verifying, to actuate the energy source to direct a pulse of the energy via the energy guide onto the target mass. | 2015-05-14 |