20th week of 2011 patent applcation highlights part 41 |
Patent application number | Title | Published |
20110117524 | UNIVERSAL DENTAL CROWN AND SYSTEM AND METHOD OF RESTORING A TOOTH USING A UNIVERSAL DENTAL CROWN - The present invention relates to dental crowns for use in restoring a prepared tooth wherein the dental crown comprises a universally sized crown shell and crown matrix to enable the sizing and fitting of the dental crown to the patient in a single sitting and without an impression or laboratory procedure. | 2011-05-19 |
20110117525 | REFRESHABLE BRAILLE DISPLAY DEVICE - Disclosed is a refreshable Braille display device comprised of a rotary character display assembly which can display a refreshable Braille character in the plane of the rotary display assembly. Also disclosed is a method of displaying a refreshable Braille character. | 2011-05-19 |
20110117526 | TEACHING GESTURE INITIATION WITH REGISTRATION POSTURE GUIDES - A method for providing multi-touch input initiation training on a display surface is disclosed. A set of one or more registration hand postures is determined, where each registration hand posture corresponds to one or more gestures executable from that registration hand posture. A registration posture guide is displayed on the display surface. The registration posture guide includes a catalogue for each registration hand posture, where the catalogue includes a contact silhouette showing a model touch-contact interface between the display surface and that registration hand posture. | 2011-05-19 |
20110117527 | WELDING TRAINING SYSTEM - A system for training welders that includes a data generating component, a data capturing component and a data processing and visualization component. The data generating component operates in real time and derives data from an actual manually-executed weld and further includes a weld process-specific jig, a calibration block positioned on the jig, wherein the geometric configuration of the calibration block is specific to a particular type of weld joint, a weld coupon positioned on the welding process-specific jig adjacent to the calibration block, a welding gun for use by a trainee, wherein the welding gun is operative to form the weld; and at least one target mounted on the welding gun that is recognized by the data processing and visualization component for providing multidimensional position and orientation feedback to the trainee. | 2011-05-19 |
20110117528 | REMOTE PHYSICAL THERAPY APPARATUS - This invention discloses methods and apparatus for tracking prescribed movement of body parts. According to the present invention multiple sensors are used to track body part motion. The tracked motion may then be compared to prescribed motion and also be stored for ascertaining compliance with a prescribed therapy regimen. | 2011-05-19 |
20110117529 | CPR Competition System - A computer-implemented method for managing rescue training includes registering a plurality of individuals as potential rescue trainees through a central computer server system, receiving from computing devices that are remote from the central server system information indicative of rate and depth of compression for ones of the potential rescue trainees, and generating comparative data that reflects performance of CPR chest compressions for a first rescue trainee against other rescue trainees. The method also includes providing the comparative data over a network for review by one or more of the rescue trainees. | 2011-05-19 |
20110117530 | METHOD AND SYSTEM OF SIMULATING PHYSICAL OBJECT INCISIONS, DEFORMATIONS AND INTERACTIONS THEREWITH - A method of simulating a formation of an incision or a deformation in a physical object. The method comprises spatially simulating a physical object in a simulation space using a volumetric arrangement of a plurality of prismatic elements, each the prismatic element having at least one adjustable parameter simulating a physical property of a respective segment of the physical object, measuring a movement of at least one simulation tool in the simulation space, selecting at least one of the plurality of prismatic elements according to the measurement, adjusting at least one adjustable parameter of at least one selected prismatic element according to the measurement, and spatially simulating an incision or deformation formed in the physical object in response to the movement using the adjusted volumetric arrangement. | 2011-05-19 |
20110117531 | MOLD FOR PRODUCING SIMULATED BLOOD VESSEL, METHOD OF PRODUCING SIMULATED BLOOD VESSEL AND SIMULATED BLOOD VESSEL - Disclosed is a method whereby a narrowed part similar to an actual lesioned blood vessel can be easily obtained. A mold ( | 2011-05-19 |
20110117532 | IMAGE COMPOSITING VIA MULTI-SPECTRAL DETECTION - A video image capture component includes a light source operable in a first spectrum, a first image detector operable in the first spectrum, a second light source operable in a second spectrum, and a second image detector operable in the second spectrum. A filtering component generates a combination image by filtering a first image obtained by the first image detector with a high-contrast filter, resulting in a high-contrast image, and masking a second image obtained by the second image detector using the high-contrast image. A compositing component creates a composite image from the combination image and a selected image. A display component displays the composite image. | 2011-05-19 |
20110117533 | Mechanical edge video application and learning system - Mechanical Edge Application is a videogame and learning program. Identity in the videogame comes with a model with interchangeable parts and an activation code. In order to advance in the videogame, actual mechanical/technical lessons have to be learned and passed. These mechanical science lessons would include knowing actual plane components/systems (boat, car) and physics behind their function. Other lessons included upgrading your characters status by a repairman learning to be a pilot by taking simulated flight lessons. Therefore, the “front end” end of the game is an exciting video game, but continuation and increased scoring and winning opportunities is based on technical science lessons of the components and mechanics of an aircraft (boat, car). | 2011-05-19 |
20110117534 | EDUCATION MONITORING - Group-based, periodic education intervention that provides a targeted curriculum selected specifically for each period based on current skill assessment data is described. For example, candidates' skill levels in multiple skills are assessed, and groups are formed based on commonality of skill level. A period-specific curriculum is generated for each group to address the specific needs of the individuals of the respective group. After delivery of the period-specific targeted curriculum over the period, re-assessments of the current skill of the group members are made, and a period-specific curriculum for the subsequent period is generated and delivered. Fidelity of an implementation of the curriculum is analyzed, and alerts, reminders, and reports are provided to improve fidelity of an implementation of the curriculum. | 2011-05-19 |
20110117535 | TEACHING GESTURES WITH OFFSET CONTACT SILHOUETTES - A method for providing multi-touch input training on a display surface is disclosed. A touch input is detected at one or more regions of the display surface. A visualization of the touch input is displayed at a location of the display surface offset from the touch input. One or more annotations are displayed at a location of the display surface offset from the touch input and proximate to the visualization, where each annotation shows a different legal continuation of the touch input. | 2011-05-19 |
20110117536 | GAME TABLE POINT OF PURCHASE DISPLAY - A display device having a segment of a functional game table, and display means attached to the segment for providing information about the segment to a viewer is disclosed. The segment of a functional game table may be taken along a longitudinal axis, transverse axis, or other section of the table. | 2011-05-19 |
20110117537 | USAGE ESTIMATION DEVICE - Predicting a transition of usage of a user on a terminal device. A trajectory made by dividing operation history information of a user on the terminal device by time, calculating a group of feature amount representing the usage for each piece of the operation history information in each division section, and connecting points corresponding to the group of feature amount on a space based on the feature amount is referred to as a usage trajectory. A processing device | 2011-05-19 |
20110117538 | BIOREACTORS FOR FERMENTATION AND RELATED METHODS - Bioreactors suitable for housing a predetermined volume of liquid comprising nutrient medium and biological culture comprising: (a) a container having at least one interior wall; (b) at least one nutrient medium inlet; (c) at least one liquid outlet; (d) at least one gas inlet; (e) at least one gas outlet; and (f) at least one cylindrical sparging filter attached to the at least one gas inlet, wherein the sparging filter comprises a plurality of pores along its axis which permit gas to be emitted radially from the sparging filter into the liquid, wherein the diameter of the plurality of pores does not exceed about 50 μm, and wherein the orientation of the at least one sparging filter within the container provides for immersion of the plurality of pores within the liquid and substantially uniform distribution of emitted gas throughout the liquid, and related methods of using said bioreactors to prepare various biological products. | 2011-05-19 |
20110117539 | Detection of an Analyte in a Sample - There is provided mechanisms for the detection of an analyte in a sample. The mechanisms utilize at least a first measurement channel comprising a detection reactant corresponding to the analyte to be detected, and at least a microstructure associated with the first measurement channel. When the mechanisms are in use, the sample is introduced into the first measurement channel and propagated by way of the first measurement channel towards the microstructure. If the analyte, if it is present in the sample, the analyte interacts with the detection reactant to form a networked product, and the microstructure is configured to filter the networked product. | 2011-05-19 |
20110117540 | Highly Simplified Lateral Flow-Based Nucleic Acid Sample Preparation and Passive Fluid Flow Control - Highly simplified lateral flow chromatographic nucleic acid sample preparation methods, devices, and integrated systems are provided for the efficient concentration of trace samples and the removal of nucleic acid amplification inhibitors. Methods for capturing and reducing inhibitors of nucleic acid amplification reactions, such as humic acid, using polyvinylpyrrolidone treated elements of the lateral flow device are also provided. Further provided are passive fluid control methods and systems for use in lateral flow assays. | 2011-05-19 |
20110117541 | Method for Screening of Agents for the Prevention of Hepatitis C Virus Infection with Cell Culture Tool - The invention relates to an improved method of screening of anti-HCV agents that may have an efficacy for prevention of hepatitis C virus. The method involves the isolation and cryopreservation of HCV-infected hepatocytes from multiple infected individuals. The isolated and cryopreserved hepatocytes are stored in a cryopreservation bank made up of HCV-infected hepatocytes representing the different genotypes of HCV. These stored hepatocytes then are co-cultured in a culture medium with uninfected hepatocytes, and anti-HCV screening of the hepatocytes is done by subjecting HCV infected hepatocytes and uninfected hepatocytes in parallel to the actions of different anti-HCV compounds at various concentrations. An effective anti-HCV agent will lead to prevention of increase in concentration of HCV content of uninfected cells in the co-culture. | 2011-05-19 |
20110117542 | REAL TIME ELECTRONIC CELL SENSING SYSTEM AND APPLICATIONS FOR CYTOTOXICITY PROFILING AND COMPOUND ASSAYS - The invention provides methods of investigating a mechanism of action of a compound, which includes providing a device for monitoring cell-substrate impedance; attaching the device to an impedance analyzer; adding cells to two or more wells; adding a test compound to at least one of the wells and providing at least one control well; monitoring impedance of the wells to obtain a series of impedance measurements; plotting impedance measurements to obtain impedance curves and comparing the impedance curves to determine a time frame at which the test compound has a significant effect on cell growth or behavior. Determining the time frame provides information on changes in cell status in response to the test compound, including cell attachment or adhesion status, cell growth or proliferation status, the number of viable or dead cells, cytoskeletal organization or structure, and the number of cells going through apoptosis or necrosis. | 2011-05-19 |
20110117543 | DIAGNOSTIC METHOD AND PRODUCTS USEFUL THEREIN - A method for simultaneous detection and identification of | 2011-05-19 |
20110117544 | METHOD FOR PRODUCING AN AMPLIFIED POLYNUCLEOTIDE SEQUENCE - There is a method for converting at least a part of a target polynucleotide sequence into a different sequence, comprising the steps of: (i) hybridising two or more first polynucleotides to adjacent positions on the target and linking first polynucleotides together, wherein at least one of the first polynucleotides comprises at least one nucleotide that is not complementary to the target; and (ii) dissociating the hybrid of step (i) and forming a second polynucleotide hybridised to the first polynucleotide, the second polynucleotide comprising at least one portion complementary to a portion on the first polynucleotide and comprising the complement to the at least one nucleotide of step (i). | 2011-05-19 |
20110117545 | GENETIC VARIANTS ON CHR2 AND CHR16 AS MARKERS FOR USE IN BREAST CANCER RISK ASSESSMENT, DIAGNOSIS, PROGNOSIS AND TREATMENT - The invention pertains to certain genetic variants on Chr2q14, Chr2q35 and Chr16q12 as susceptibility variants of breast cancer. Methods of risk assessment and diagnosis of increased and/or decreased susceptibility to breast cancer, using such variants are described. The invention further relates to kits for diagnosing a susceptibility to breast cancer. | 2011-05-19 |
20110117546 | INCREASE OF SIGNAL SENSITIVITY USING DUAL PROBES IN PCR REACTIONS - A method increases the signal strength generated when performing real-time PCR on a target nucleic acid sequence. The method performs real-time PCR using forward primers, forward probes, reverse primers, reverse probes, nucleotides for strand/antistrand extension, and nucleic acid polymerase. Two different types of probes are used, a forward probe configured to anneal to a sense strand of a target nucleic acid sequence and a reverse probe configured to anneal to an antisense strand of the target nucleic acid sequence. The forward probe is complementary to an inner sequence of the target sense strand, and the reverse probe is complementary to an inner sequence of the target antisense strand. The forward probe and the reverse probe each include the same detectable element, that when released from the probe during strand extension results in an additive detectable signal. | 2011-05-19 |
20110117547 | TARGET DNA DETECTION METHOD AND TARGET DNA DETECTION KIT - The present invention provides a method for detecting a target DNA easily and highly accurately through simultaneous analysis of a sense strand and an antisense strand of the target DNA, and a kit therefor. The target DNA detection method of the present invention is a method for detecting a target DNA composed of a sense strand having a target nucleotide sequence and an antisense strand complementary to the sense strand, wherein: a first oligonucleotide which hybridizes with the sense strand, and a second oligonucleotide which hybridizes with the antisense strand are used; at least a part of a region, of the antisense strand, which hybridizes with the second oligonucleotide is complementary to at least a part of a region, of the sense strand, which hybridizes with the first oligonucleotide; and the first oligonucleotide and the second oligonucleotide are simultaneously added into one reaction solution to effect respective hybridizations with the target DNA, followed by ligation reactions and/or PCR, thereby detecting resultant products. | 2011-05-19 |
20110117548 | Detecting Fetal Chromosomal Abnormalities Using Tandem Single Nucleotide Polymorphisms - The invention provides tandem single nucleotide polymorphisms and methods for their use, for example, in diagnosing Down Syndrome. | 2011-05-19 |
20110117549 | METHOD FOR DETECTING NUCLEIC ACID, AND DEVICE OR KIT - The present invention has its object to provide a method and a device or kit for detecting a nucleic acid, which enable simple and precise visual detection of a nucleic acid amplified by a nucleic acid amplification method, without necessity of a special device. | 2011-05-19 |
20110117550 | METHOD OF DETERMINING ANTI-HYPERTENSIVE DRUG THERAPY BY GENETIC PROFILING - The present invention comprises a method for determining an anti-hypertension therapy for an individual based upon the presence or absence of specific alleles affecting baseline blood pressure and sensititivity to different therapeutic formulations. | 2011-05-19 |
20110117551 | DETECTION AND PROGNOSIS OF LUNG CANCER - Methods and tools are provided for detecting and predicting lung cancer. The methods and tools are based on epigenetic modification due to methylation of genes in lung cancer or pre-lung cancer. The tools can be assembled into kits or can be used seperately. Genes found to be epigentically silenced in association with lung cancer include ACSL6, ALS2CL, APC2, ART-S1, BEX1, BMP7, BNIP3, CBR3, CD248, CD44, CHD5, DLK1, DPYSL4, DSC2, EDNRB, EPB41L3, EPHB6, ERBB3, FBLN2, FBN2, FOXL2, GNAS, GSTP1, HS3ST2, HPN, IGFBP7, IRF7, JAM3, LOX, LY6D, LY6K, MACF1, MCAM, NCBP1, NEFH, NID2, PCDHB15, PCDHGA12, PFKP, PGRMC1, PHACTR3, PHKA2, POMC, PRKCA, PSEN1, RASSF1A, RASSF2, RBP1, RRAD, SFRP1, SGK, SOD3, SOX17, SULF2, TIMP3, TJP2, TRPV2, UCHL1, WDR69, ZFP42, ZNF442, and ZNF655. | 2011-05-19 |
20110117552 | METHODS OF USING A NOD2/CARD15 HAPLOTYPE TO DIAGNOSE CROHN'S DISEASE - The present invention provides a method of diagnosing or predicting susceptibility to Crohn's disease in an individual by determining the presence or absence in the individual of a disease-predisposing haplotype containing a JW1 variant allele at the NOD2/CARD15 locus, where the presence of the disease-predisposing haplotype is diagnostic of or predictive of susceptibility to Crohn's disease. | 2011-05-19 |
20110117553 | Methods for PCR and HLA typing using raw blood - Provided are methods for amplifying a gene or RNA or sets thereof of interest using a tandem PCR process. The primers in the first PCR or set of PCR reactions are locus-specific. The primers in the second PCR or set of PCR reactions are specific for a sub-sequence of the locus-specific primers and completely consumed during the secondary PCR amplification. For RNA amplification, the first PCR is reverse transcription and the resulting cDNA(s) provide a template for cRNA synthesis, endpoint PCR or real time PCR. Also provided is a method of allelotyping a gene or set thereof by amplifying the gene(s) using tandem PCR on DNA or RNA comprising the sample, hybridizing the resulting amplicon or sets thereof to probes with sequences of gene-associated allele variations. A detectable signal indicating hybridization corresponds to an allelotype of the gene or a set of allelotypes for the set of genes. | 2011-05-19 |
20110117554 | Formamide-containing mixtures for detecting nucleic acids - Specific sequences of DNA are often detected by a process that comprises a step where the sequence to be detected (the “analyte”) binds to give a duplex with a DNA molecule or analog that is complementary in the Watson-Crick sense to some portion of the analyte in an aqueous “assay environment” that may contain buffer, salt, and/or detergent. Such purely aqueous systems cannot be exposed indefinitely to the environment, however, as the water in the system will evaporate. Further, such systems often support the growth of bacteria and other organisms, destroying their effectiveness. This invention provides for compositions of matter and processes that use them that comprise assay mixtures containing more than 40% formamide. This mixture remains a liquid at equilibrium with water in environments normally inhabited by humans. This invention also provides for mixtures containing formamides that include detergents. Formamide is usually regarded as a denaturant for duplex formation, destabilizing the binding that is key to detection. This invention therefore also provides for materials that form duplexes in formamide-water mixtures. | 2011-05-19 |
20110117555 | CD38 as a prognostic indicator in chronic lymphocytic leukemia - The subject invention discloses a method for determining the prognosis and probable clinical course of a subject diagnosed with B-CLL. Specifically, the invention involves comparing CD38 expression in a biological sample from the subject containing B-CLL cells to a baseline level of CD38 expression, wherein an elevated level of CD38 expression in relation to the baseline level of CD38 expression may indicate poor prognosis or aggressive course of disease in the subject. Also disclosed is a method for determining whether the Ig V genes of the B-CLL cells of a B-CLL patient are mutated, comprising comparing CD38 expression in a biological sample from the subject containing B-CLL cells to a baseline level of CD38 expression, wherein a lower level of CD38 expression in relation to the baseline level indicates IG V gene mutation. | 2011-05-19 |
20110117556 | HIGH-SENSITIVE FLUORESCENT ENERGY TRANSFER ASSAY USING FLUORESCENT AMINO ACIDS AND FLUORESENT PROTEINS - The disclosure provides method and composition utilizing fluorescent amino acids and endogenous fluorescent proteins comprising a moiety capable of undergoing FRET. The methods and compositions of the disclosure are useful in analyzing protein structure and function, and screening molecular inhibitors. | 2011-05-19 |
20110117557 | Methods and Compositions For Diagnosis of Age-Related Macular Degeneration - The invention generally concerns methods and compositions for screening individuals for susceptibility to age-related macular degeneration (AMD). In particular, association with the various markers including complement factor H, LOC387717/ARMS2, C2/CFB, C3 and VEGF, indicates that a subject is at risk of AMD. | 2011-05-19 |
20110117558 | DIAGNOSIS OF HEREDITARY SPASTIC PARAPLEGIAS (HSP) BY IDENTIFICATION OF A MUTATION IN THE ZFYVE26 GENE OR PROTEIN - The Invention relates to an ex vivo method of diagnosing or predicting a hereditary spastic paraplegias (HSP), in a subject, which method comprises detecting a mutation in the ZFYVE26 gene or protein (spastizin), wherein said mutation is indicative of a hereditary spastic paraplegias (HSP). | 2011-05-19 |
20110117559 | SMALL RNA DETECTION ASSAYS - The present invention comprises use of cleavable primers to perform qPCR detection of cDNA made from small RNA species. The cleavable primers offer improved specificity over standard PCR primers and are the method is compatible with a variety of methods to introduce priming sites at the 5′-end and 3′-end of the small RNA species. | 2011-05-19 |
20110117560 | ASSESSING LEFT VENTRICULAR REMODELING VIA TEMPORAL DETECTION AND MEASUREMENT OF microRNA IN BODY FLUIDS - Disclosed are methods and materials for assessing cardiac failure, cardiac hypertrophy, and left ventricular remodeling using microRNA levels. The level of microRNAs can be measured in a body fluid, such as plasma and serum. | 2011-05-19 |
20110117561 | Magnetic Pigment - Magnetic particles with an outer glass surface being essentially poreless or having pores of a diameter of less then 10 nm as well as ferromagnetic particles with a glass surface are preferentially useful for the isolation of biological material from samples. They provide a quick and reliable purification. | 2011-05-19 |
20110117562 | Diagnosis and Treatment of Chronic Lymphocytic Leukemia (CLL) - The present invention provides diagnostic methods and kits for diagnosis of chronic lymphocytic leukemia (CLL) by determining expression levels of isoforms of cyclic nucleotide phosphodiesterases (PDEs) associated with CLL, particularly, PDE7B and/or PDE3B, and a ratio of mRNA expression of PDE7B to PDE3B. The present invention provides that CLL lymphocytes uniformly expressed high levels of PDE7B and low levels of PDE3B relative to those of normal lymphocytes. A method of treatment and a pharmaceutical composition for CLL comprising one or more therapeutic agents capable of modulating expression or activity levels of isoforms of PDEs associated with CLL, and/or reversing the ratio of PDE7B/PDE3B mRNA expression levels are also provided. | 2011-05-19 |
20110117563 | ANTIVIRAL THERAPY - The application relates to treatments for improving antiviral therapies and to method for determining whether or not antiviral therapies will be effective. In particular, the present application provides a method for determining the likelihood that a subject having a viral infection of the liver will be responsive to antiviral therapy that includes stimulation of Interferon (IFN) activity, and kits for the performance of said determination. | 2011-05-19 |
20110117564 | COMPOSITIONS, KITS AND RELATED METHODS FOR THE DETECTION AND/OR MONITORING OF SALMONELLA - Provided are compositions, kits, and methods for the identification of | 2011-05-19 |
20110117565 | SERUM OR PLASMA MICRORNA AS BIOMARKERS FOR NON-SMALL CELL LUNG CANCER - The present invention provides non-small cell lung cancer markers and the use thereof. The non-small cell lung cancer markers in the present invention include at least one of the 26 selected detectable mature microRNAs existing stably in human serum or plasma. The invention also provides a probe combination, kit and biochip for detecting the non-small cell lung cancer markers. The invention further provides a method for detecting microRNAs in the serum of lung cancer patients. By detecting the variations of microRNAs in the serum of lung cancer patients, the disease can be diagnosed in vitro; the progression course of the disease can be predicted; the occurrence of complications, the rate of relapse and the prognosis of the disease can be monitored; the drug efficacy and therapeutic effects can be analyzed. The method in the present invention enables extensive detection spectrum, high sensitivity, low cost, convenient sample taking and preservation. The method can be applied in the general survey of disease, solves problems of the low specificity and sensitivity encountered with previous single markers, and increases significantly the clinical detection rate of diseases, all of which make it an effective means for diagnosing diseases at an early stage. | 2011-05-19 |
20110117566 | Model System for Diagnosing Lipid Metabolism - The invention relates to a population model for the analysis of blood lipoprotein physiology in a test subject comprising: a. a submodel for the production of blood lipoproteins; b. a submodel for the lipolysis of blood lipoproteins; c. a submodel for the reabsorption of blood lipoproteins; and d. a submodel relating blood lipoprotein particle size to biochemical composition, more specifically triglyceride content, there-by providing an analysis of the physiological processes underlying a steady state particle population distribution. Each submodel is given as function, using the size of the lipoprotein particle as the independent variable. | 2011-05-19 |
20110117567 | Micro-RNA Associated With Rheumatoid Arthritis - An object of the present invention is to provide a novel marker for rheumatoid arthritis (RA), and more specifically, to provide a marker whose expression may be specifically increased or decreased in RA. Another object of the present invention is to confirm whether or not miRNA serving as the marker is involved as the etiology of RA, and to provide an inspection method for RA and a therapeutic agent for RA each using the miRNA involved. The marker includes miRNA (for example, miR124a) whose expression is specifically increased or decreased in RA synovial cells based on a small RNA expression profile in the RA synovial cells. In addition, the therapeutic agent for RA includes miRNA (for example, miR124a) as an active ingredient. | 2011-05-19 |
20110117568 | Method for Amplifying Target Nucleic Acid Sequence, Method for Detecting Mutation Using the Same, and Reagent Used for the Same - The present invention provides a method for detecting a mutation capable of detecting a mutation with high sensitivity and high reliability in one reaction system. Using primers (Xmt) and (Xwt), a target nucleic acid sequence whose objective base to be detected is a mutant-type is amplified with amplification efficiency higher than a target nucleic acid sequence whose objective base to be detected is a normal-type. The (Xmt) is a primer that is complementary to a region including a mutant-type base in the template nucleic acid and has a base complementary to a mutant-type base at a 3′ region, and the (Xwt) is a primer that is complementary to a region including a normal-type base in the template nucleic acid and has a base complementary to a normal-type base at a 3′ region. It is preferable that amplification efficiency by the (Xmt) with reference to a mutant-type template nucleic acid is higher than that by the (Xwt) with reference to a normal-type template nucleic acid. Then, a signal value that shows a molten state of a hybridization product between the thus obtained amplification product and the probe is measured, and the presence or absence of the mutation of the objective base site is determined from a change in the signal value accompanying a change in the temperature. | 2011-05-19 |
20110117569 | POLYMIDE NUCLEIC ACID DERIVATIVES, AND AGENTS AND PROCESSES FOR PREPARING THEM - The present invention relates to PNA derivatives which carry, at the C terminus, or at both the C and N termini of the PNA backbone, one or more phosphoryl radicals. The phosphoryl radicals carry, where appropriate, one or more labeling groups, groups for crosslinking, groups which promote intracellular uptake, or groups which increase the binding affinity of the PNA derivative for nucleic acids. The invention furthermore relates to a process for preparing the above-mentioned PNA derivatives and to their use as pharmaceuticals or diagnostic agents. | 2011-05-19 |
20110117570 | METHODOLOGIES, PROCESSES AND AUTOMATED DEVICES FOR THE ORIENTATION, SAMPLING AND COLLECTION OF SEED TISSUES FROM INDIVIDUAL SEED - Apparatus, methods, and systems for high throughput, useful sampling of seed, wherein viability is optionally maintained, are disclosed. Seed from one generation in a plant advancement experiment is individually sampled by removal and collection of tissue from the seed. The tissue is then processed to derive one or more biochemical, genetic, or phenotypic characteristic of the seed before a decision is made whether to utilize that seed further in a plant advancement experiment or other plant research and development. In some embodiments of the method, the sampling is controlled to remove a useful amount of tissue for analytical purposes without significant effect on viability potential of the sampled seed. In some embodiments, the sampling is controlled to deter contamination of the sample. In some embodiments, the seed is automatically positioned and oriented to facilitate efficient and accurate sampling. | 2011-05-19 |
20110117571 | Transporter assay - This invention concerns a non-radioactive homogenous proximity assay for cellular transport system. The assay format disclosed here takes advantageous of the fact that ABC transporters have two similar ATP binding sites, and thus allowing two ATP molecules to bind simultaneously to these adjacent sites. | 2011-05-19 |
20110117572 | Antibody Specific to the AIMP2-DX2 - The present invention relates to a variant of AIMP2 lacking exon 2 gene, named as AIMP2-DX2 gene, which is specifically expressed in cancer cells. The AIMP2-DX2 gene and siRNA targeting AIMP2-DX2 can be successfully used in the development of diagnosis and treatment of cancer | 2011-05-19 |
20110117573 | CELL DIVISION MARKER - This application relates to a newly identified animal cell structure, the midbody scar. This structure is a remnant of the midbody that is retained by one daughter cell following cytokinesis and persists through multiple subsequent cell cycles. The midbody scar can be useful as a marker of dividing cells or of a cell's replicative age. | 2011-05-19 |
20110117574 | FLUORESCENCE BASED ASSAY TO DETECT SODIUM/CALCIUM EXCHANGER "FORWARD MODE" MODULATING COMPOUNDS - Transporters are an emerging target family with enormous potential, offering scientific and economic opportunities. The sodium/calcium exchanger is an important mechanism for removing Ca | 2011-05-19 |
20110117575 | ISOLATION AND/OR IDENTIFICATION OF STEM CELLS HAVING ADIPOCYTIC, CHONDROCYTIC AND PANCREATIC DIFFERENTIATION POTENTIAL - The present invention relates to a method for isolating and/or identifying stem cells having adipocytic, chondrocytic and pancreatic differentiation potential, wherein an antibody is used that binds to the antigen TNAP, alone or in combination with an antibody that binds to the cell surface antigen CD56. The invention also relates to stem cells isolated by the method according to the invention for treating defects or damages or diseases in bone or cartilage of a patient in need thereof. | 2011-05-19 |
20110117576 | MCT-1, A HUMAN ONCOGENE - A novel gene, designated MCT-1 (for Multiple Copies in T-cell malignancy), is provided. A protein encoded by MCT-1, designated MCT-1, is also provided. Antisense oligonucleotides complementary to or homologous with a portion of MCT-1, substantially purified MCT-1, and methods of determining whether a cell is a tumor cell are also provided. The invention also includes monoclonal and polyclonal antibody preparations which bind with specificity to MCT-1. The invention further includes methods of determining whether a compound or a gene product is a modulator of MCT-1 expression, a method of reducing MCT-1 expression in a cell, and a method of conferring a growth advantage on a cell. | 2011-05-19 |
20110117577 | MICROFLUIDIC SYSTEM FOR TRAPPING AND DETECTION OF A BIOLOGICAL ENTITY IN A SAMPLE - According to embodiments of the present invention, a microfluidic system for detecting a biological entity in a sample volume is provided. The microfluidic system includes: an inlet configured to receive the sample volume; at least one microchannel in fluid communication with the inlet; a magnetic trapping region comprising the at least one microchannel; at least one detection region in fluid communication with the magnetic trapping region for detecting the biological entity to be detected; and at least one outlet in fluid communication with the at least one detection region. | 2011-05-19 |
20110117578 | BIOMARKER FOR SELECTING PATIENTS AND RELATED METHODS - The present invention concerns methods for inducing an immune response to an antigen in a patient for treating human disease by administering an immunogenic composition wherein said patient is selected in a patient population of interest. The present invention further concerns methods for determining whether a subject is or is not susceptible to developing a prophylactic or therapeutic immune response after such treatment. | 2011-05-19 |
20110117579 | System and Method for Quantitative Assessment of Biological Migration Behavior - The present invention provides systems and methods for assessing migration behavior of biological particles, such as neutrophils, under the effect of a gradient. The systems can include one or more migration chambers, one or more gradient sources configured to generate particular gradients, e.g., of chemokines or the like across the width of the migration chamber, and a detection arrangement that is configured to determine spatial profiles across the migration chamber that indicate the extent of migration. | 2011-05-19 |
20110117580 | REDUCING LEUKOCYTE INTERFERENCE IN NON-COMPETITIVE IMMUNOASSAYS - The invention is directed to methods and devices for reducing interference from leukocytes in an analyte immunoassay, and in particular in non-competitive immunoassays. In one embodiment, the invention is to a method comprising the steps of (a) amending a biological sample such as a whole blood sample with sacrificial beads; and (b) performing a non-competitive immunoassay on the amended sample to determine the concentration of said analyte in said sample. Preferably, the sample is amended with IgG-coated sacrificial beads. | 2011-05-19 |
20110117581 | REDUCING LEUKOCYTE INTERFERENCE IN COMPETITIVE IMMUNOASSAYS - The invention is directed to methods and devices for reducing interference from leukocytes in an competitive analyte immunoassays. In one embodiment, the invention is to a method comprising the steps of (a) amending a biological sample such as a whole blood sample with sacrificial beads opsonized for leukocytes; and (b) performing a competitive immunoassay on the amended sample to determine the concentration of said analyte in said sample. Preferably, the sample is amended with IgG-coated sacrificial beads. | 2011-05-19 |
20110117582 | MULTI-BIOMARKER BIOSENSOR - Nanosubstrates as biosensors, methods of making such nanosubstrates, and methods of using such nanosubstrates to detect biomarkers are described. | 2011-05-19 |
20110117584 | Detection of Chronic Kidney Disease Patients or Coronary Artery Disease Using Bone Morphogenic Protein-4 - The invention is a method of detecting CAD in a CKD diagnosed human patient or CKD in a CAD diagnosed human patient, or detection of the presence of both CKD and CAD by assaying a plasma or serum sample of a human patient for elevated levels of BMP-4. | 2011-05-19 |
20110117585 | Quantitative multiplex detection of pathogen biomarkers - The present invention addresses the simultaneous detection and quantitative measurement of multiple biomolecules, e.g., pathogen biomarkers through either a sandwich assay approach or a lipid insertion approach. The invention can further employ a multichannel, structure with multi-sensor elements per channel. | 2011-05-19 |
20110117586 | Protocol for Risk Stratification of Ischemic Events and Optimized Individualized Treatment - A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, through platelet-fibrin interaction and lysis to generate blood hemostasis parameters. The measured blood hemostasis parameters permit preparation of an individualized assessment of ischemic event risk and individualized treatment of a subject. | 2011-05-19 |
20110117587 | SINGLE MOLECULE DETECTION PLATFORM, MANUFACTURING METHOD THEREOF AND METHOD USING THE SAME - A single molecule detection platform is disclosed. The single molecule detection platform comprises a light-transmissive substrate, a plurality of spherical particles and a thin film. The surface of the light-transmissive substrate is etched to form a plurality of cone-shaped structures. Each spherical particle is disposed on top of each cone-shaped structure. The sizes of the plurality of spherical particles are suitable to allow only a single protein to be attached to each spherical particle. The thin film is deposited on the surface of the plurality of cone-shaped structures and acts as a reflective layer of one-dimensional waveguide. The plurality of spherical particles is not covered by the thin film. | 2011-05-19 |
20110117588 | METHOD OF PREDICTING DRUG-INDUCED PHOSPHOLIPIDOSIS - The present invention provides a method of predicting drug-induced phospholipidosis, comprising a step of contacting a mammalian cell with a test compound, a step of measuring extracellular and/or intracellular lysosomal enzyme level or activity, or measuring intracellular LC3 level, and a step of selecting a test compound that has enhanced extracellular secretion of the enzyme or increased the protein level as a compound capable of inducing drug-induced phospholipidosis. | 2011-05-19 |
20110117589 | USE OF PROCALCITONIN (PCT) IN PROGNOSIS FOLLOWING ACUTE CORONARY SYNDROMES - Subject of the present invention are assays and in vitro methods for determining a prognosis for a patient having an acute coronary syndrome, whereby the level of procalcitonin or fragments thereof is measured in a sample obtained from said patient. Said level of procalcitonin or fragments thereof may then be correlated to a predisposition to an adverse outcome of said acute coronary syndrome. | 2011-05-19 |
20110117590 | Heavy Metal Biosensor - Compositions and methods are provided for detection of certain heavy metals using bacterial whole cell biosensors. | 2011-05-19 |
20110117591 | CHEMICAL PROBE COMPOUNDS THAT BECOME FLUORESCENT UPON REDUCTION, AND METHODS FOR THEIR USE - Chemical stain compounds containing a fluorophore and a reducible quenching unit are disclosed. The reducible quenching unit quenches the fluorophore while in its oxidized state. Upon reduction, the quenching properties of the quenching unit are diminished or eliminated. The chemical compounds can be used in a variety of applications, including the detection of bacterial cells, monitoring the electron transport chain function of bacterial cells, monitoring the oxidation state of non-biological systems, and assaying the effectiveness of antibacterial or antimicrobial agents. | 2011-05-19 |
20110117592 | Methods for Natural Product Optimization - Methods and compositions for natural product optimization are provided. In particular, methods and compositions for selecting bacterial strains (e.g., predatory bacteria such as myxobacteria) which produce a desired compound (e.g., antibiotic, antifungal, or anticancer agent) are provided. | 2011-05-19 |
20110117593 | CELL DISPERSION METHOD, CELL DISPERSING AGENT AND CELL MEASUREMENT METHOD - A cell dispersion method, a cell dispersing agent and a cell measurement method, each of which can disperse a cell mass while reducing damage to a cell are provided. Upon dispersing a cell mass, a fluororesin particle is used. A cell mass composed of an aggregated of multiple cells is mixed with a fluororesin particle in a liquid medium, thereby separating the cell mass into individual cells to disperse the cells. In addition, the dispersed cells are measured by flow cytometry, thereby carrying out cell measurement. | 2011-05-19 |
20110117594 | PROBE CONNECTOR ASSEMBLY AND MEHTOD OF USE - A probe assembly includes a tubular sleeve having a passage extending between a first end and an opposing second end. The tubular sleeve is movable between an extended position wherein the first end and the opposing second end are spaced apart and a collapsed position wherein the first end and the opposing second end are moved closer together. A connector is secured to the second end of the tubular sleeve, the connector having an opening extending therethrough that communicates with the passage of the tubular sleeve, a sealing layer removably covering the opening of the connector. An elongated probe has a first end and an opposing second end, the second end of the probe being positioned within the passage of the tubular sleeve, the second end of the probe being configured to pass through the opening of the connector when the sealing layer is removed therefrom. | 2011-05-19 |
20110117595 | Testing Unit and Method for Testing a Sterilization Packaging Unit - A testing unit and a method of testing a sterilization packaging unit for microbial contamination of sterilized objects after they have been sterilized are disclosed. The testing unit includes a dry matrix for accommodating a nutrient medium and a receptacle containing a liquid. By applying the liquid onto the matrix, the matrix is provided with a nutrient medium. In the method, the testing unit is inserted into the sterilization packaging unit which is sterilized and stored. At a desired point in time, the receptacle is opened in order to produce the nutrient medium in the matrix. After a possible multiplication of microbes on the matrix, an observation of microbes takes place. The invention also relates to a sterilization packaging unit which has a rigid outer casing and is suitable for the application of the method. | 2011-05-19 |
20110117596 | COMPOSITE SORBENT MATERIAL, ITS PREPARATION AND ITS USE - A composite sorbent material is disclosed which comprises A) a housing of a dense, insoluble material having openings therein and B) a porous polymer gel housed within said housing, said housing being provided with openings therein for fluid communication between said porous monolithic polymer gel and the surroundings, and said porous monolithic polymer gel occupying the inner space of said housing and being kept on place within said housing by mechanical means. Processes for the preparation of composite sorbent materials by cryoprecipitation are also disclosed as well as the use of the composite sorbent material according to the invention e.g. for the removal of pollutants from gases or liquids, for the enrichment or separation of molecules and for cell culture. | 2011-05-19 |
20110117597 | Enhancement of in vitro translation by nanoparticle conjugates - Provided herein are kits and methods suitable for enhancing in vitro translation of a nuclei acid sequence of interest. | 2011-05-19 |
20110117598 | Enhanced Protein Production in Bacillus - The present invention relates to cells that have been genetically manipulated to have an altered capacity to express and/or produce proteins of interest. In particular, the present invention relates to modified host cells of Gram-positive microorganisms, such as | 2011-05-19 |
20110117599 | ARTIFICIAL ENTROPIC BRISTLE DOMAIN SEQUENCES AND THEIR USE IN RECOMBINANT PROTEIN PRODUCTION - Compositions and methods for recombinant protein production and, more particularly, fusion polypeptides, polynucleotides encoding fusion polypeptides, expression vectors, kits, and related methods for recombinant protein production. | 2011-05-19 |
20110117600 | PROCESS FOR OBTAINING ASPART INSULIN USING A PICHIA PASTORIS YEAST STRAIN - The present invention refers to a method for producing a human insulin analogue with high efficiency and excellent yield, by means of a biotechnological process comprising transformation of a | 2011-05-19 |
20110117601 | Glycosylation Profile Analysis - The present invention provides a method for the production of a glycosylated heterologous polypeptide comprising the steps of obtaining a sample from a crude fermentation broth, incubation of the sample with magnetic affinity beads, releasing glycans from the immobilized glycosylated polypeptides, measuring a glycosylation profile, comparing the glycosylation profile with a desired glycosylation profile of the recombinant glycosylated polypeptide, modifying the culture conditions in accordance to the glycosylation profile obtained, and repeating the process in order to obtain a glycosylated heterologous polypeptide with the desired glycosylation profile. With a similar method diagnostic markers can be identified and quantified. | 2011-05-19 |
20110117602 | HUMAN ANTIBODY CAPABLE OF INDUCING APOPTOSIS - A human antibody that has a specific reactivity with multiple tumor cell lines including ATL cells and possesses both safety and therapeutic efficacy and a fragment of said antibody are provided. A human antibody and a fragment of said antibody that may recognize HLA-DR β chain expressed on the surface of tumor cells were obtained. In particular, it was found that a dimer of scFv (diabody) of said antibody may induce potent apoptosis in cells expressing the HLA-DR β chain. The antibody and a fragment of said antibody obtained in accordance with the present invention are useful for a detection reagent, a diagnostic and a medicament for protection or treatment of cancers including ATL and/or viral infectious diseases. | 2011-05-19 |
20110117603 | ENHANCEMENT OF CELLULAR PRODUCTION THROUGH MECHANOTRANSDUCTION - Disclosed herein are methods of modulating protein production via the application of tensegrity forces on cells and cell cultures. The methods of the invention increase production of protein from cells and cell culture. The tensegrity forces can be stress that is applied to the cells, and can include one or more of the following: mechanical stress, shear stress, stretch effects, and pressure induced stress. | 2011-05-19 |
20110117604 | COPPER-ENRICHED BIOMASS, METHOD FOR THE PREPARATION THEREOF AND PRO-BIOTIC , COSMETIC, DIETARY AND NUTRACEUTIC PRODUCTS COMPRISING THE SAME - The invention relates to a method for the preparation of a copper-enriched biomass, comprising, in a first step, culturing | 2011-05-19 |
20110117605 | Methods for Manufacturing a Polyclonal Protein - The invention relates to methods for manufacturing drug products comprising at least two distinct members of a polyclonal protein, for example a polyclonal antibody, where each distinct member is expressed by a separate population of cells. The methods involve at least an initial step in which the cell populations expressing the distinct members of the polyclonal protein are cultured separately. The individual cell populations, or proteins expressed by the individual cell populations, are combined at a later point of the upstream or downstream processing to result in a single drug product comprising the distinct members of the polyclonal protein. | 2011-05-19 |
20110117606 | NRPS-PKS Gene Cluster and its Manipulation and Utility - The present invention provides a nucleic acid molecule comprising: (a) a nucleotide sequence as shown in SEQ ID No. 1; or (b) a nucleotide sequence which is the complement of SEQ ID No. 1; or (c) a nucleotide sequence which is degenerate with SEQ ID No. 1; or (d) a nucleotide sequence having at least 85% sequence identity (preferably at least 87%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% sequence identity) with SEQ ID No. 1; or (e) a part of any one of (a) to (d), wherein said nucleic acid molecule encodes or is a complementary to a nucleic acid molecule encoding one or more polypeptides, or comprises or is complementary to a nucleic acid molecule comprising one or more genetic elements, having functional activity in the synthesis of a polyketide-based or macrolactam molecule. Particularly the invention contemplates the modification of the nucleic acid of the invention, encoding the biosynthetic machinery for the synthesis of the polyketide macrolactam BE-14106, including expressing in a microorganism the modified nucleic acid molecule. In certain aspects the modification includes introducing, mutating, deleting, replacing or inactivating a sequence encoding one or more activities or proteins encoded by said nucleic acid molecule. Other aspects of the invention include a microorganism containing the modified and unmodified nucleic acid and recovering the polyketide-based or macrolactam molecule from said mircoorganism. | 2011-05-19 |
20110117607 | ANNULAR COMPRESSION SYSTEMS AND METHODS FOR SAMPLE PROCESSING DEVICES - Systems and methods for processing sample processing devices. The system can include a base plate adapted to rotate about a rotation axis. The base plate can include at least one first magnetic element. The system can further include an annular cover, and a sample processing device comprising at least one thermal process chamber. The annular cover can include an inner edge, an outer edge, and at least one second magnetic element. The method can include positioning the sample processing device between the base plate and the annular cover, such that the inner edge of the annular cover is positioned inwardly of the at least one thermal process chamber, and such that the at least one first magnetic element attracts the at least one second magnetic element to force the annular cover in a first direction along the z-axis, urging the sample processing device into contact with the base plate. | 2011-05-19 |
20110117608 | DOUBLE-STRANDED NUCLEIC ACID - The invention is directed towards constructs for RNAi techniques. The invention provides a ribonucleic acid (RNA) for use as interfering RNA in gene silencing techniques to silence a target gene comprising in a 5′ to 3′ direction at least a first effector sequence, a second effector sequence, a sequence substantially complementary to the second effector sequence and a sequence substantially complementary to the first effector sequence, wherein the complementary sequences are capable of forming double stranded regions with their respective effector sequences and wherein at least one of these sequences is substantially identical to the predicted transcript of a region of the target gene, and a nucleic acid construct encoding such an RNA. | 2011-05-19 |
20110117609 | Homologous Recombination Method, Cloning Method, and Kit - Disclosed is a method which can achieve the homologous recombination of a gene of interest selectively. Also disclosed is a recombinant DNA molecule produced by the method. Specifically disclosed is a homologous recombination method which uses a PCR product and a linearized vector. The PCR product comprises a sequence for a target gene and amplification primer sequences P | 2011-05-19 |
20110117610 | Modified Dicer Polypeptide and Methods of Use Thereof - A modified Dicer polypeptide is provided, which modified Dicer polypeptide exhibits enhanced catalytic activity. Also provided is a method for producing small regulatory RNAs from a dsRNA, involving contacting a dsRNA with a subject modified Dicer. Small regulatory RNAs produced by a subject method find use in a variety of applications, including research and therapeutic applications. | 2011-05-19 |
20110117611 | Nucleotide Sequences Which Code for the tal Gene - The invention relates to an isolated polynucleotide from coryneform bacteria, comprising a polynucleotide sequence chosen from the group consisting of
| 2011-05-19 |
20110117612 | CORYNEFORM BACTERIUM TRANSFORMANT HAVING IMPROVED D-XYLOSE-UTILIZING ABILITY - A coryneform bacterium transformant prepared by transferring an exogenous gene which encodes a protein having a sugar transporter function into a coryneform bacterium capable of utilizing D-xylose. | 2011-05-19 |
20110117613 | METHOD FOR PRODUCTION OF L-AMINO ACID - An L-amino acid can be produced by culturing a bacterium which belongs to the Enterobacteriaceae family, and has an enhanced ability to use a fatty acid. The bacterium is capable of producing the L-amino acid in a culture medium containing a fatty acid or a hydrolysate of an oil-and-fat as a carbon source, thereby producing and accumulating the L-amino acid in a culture. | 2011-05-19 |
20110117614 | Production Process for Methionine Using Microorganisms with Reduced Isocitrate Dehydrogenase Activity - The present invention is directed to a method utilizing a microorganism with reduced isocitrate dehydrogenase activity for the production of methionine. | 2011-05-19 |
20110117615 | PRODUCTION PROCESS - The invention relates to a process for producing organic acids, acid derivatives thereof and/or organic alcohols. In particular, the invention relates to a process for culturing a butyric acid-producing micro-organism in a culture vessel; transferring a portion of the butyric acid which is produced in the culture vessel to a separate compartment; and then reintroducing a portion of the acids from the second compartment in a controlled manner into the culture vessel. The invention also relates to a process for making butanol. The invention further relates to a process for culturing a butyrate-producing micro-organism in a first compartment of an electrochemical reactor, passing a direct current electric field across the electrochemical reactor and harvesting butyric acid or acid derivatives thereof in a second compartment of the reactor. The invention further relates to a process for producing butanol from the butyric acid. | 2011-05-19 |
20110117616 | METHOD FOR PRODUCING (1S,2R)-2-CHLORO-2-FLUOROCYCLOPROPANECARBOXYLIC ACID - The present invention provides a method for producing (1S,2R)-2-chloro-2-fluorocyclopropanecarboxylic acid with a high yield and high selectivity. Specifically, disclosed is a method for producing (1S,2R)-2-chloro-2-fluorocyclopropanecarboxylic acid, wherein (1S)-2-chloro-2-fluorocyclopropanecarboxylic acid ester is hydrolyzed using an esterase derived from Burkholderia cepacia. | 2011-05-19 |
20110117617 | METHODS AND GENETICALLY ENGINEERED MICRO-ORGANISMS FOR THE COMBINED PRODUCTION OF PDO, BDO AND PHP BY FERMENTATION - The present invention relates to methods and genetically engineered micro-organisms for the combined production of PDO, BDO, and PHP by fermentation. The micro-organism is characterized in that its D-lactate dehydrogenase gene has been deleted or functionally inactivated, and it comprises heterogenous polynucleotides encoding the Coenzyme A-dependent Aldehyde dehydrogenase and the Polyhydroxyalkanoate synthase. Methods for the construction of such micro-organisms are also disclosed | 2011-05-19 |
20110117618 | Methods and Compositions for the Recombinant Biosynthesis of n-Alkanes - The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently convert carbon dioxide and light into n-alkanes, and in particular the use of such organisms for the commercial production of n-alkanes and related molecules. | 2011-05-19 |
20110117619 | Method for Pretreatment of Cellulosic and Lignocellulosic Materials for Conversion into Bioenergy - A process for converting organic waste materials into usable products and products thereof is disclosed. According to the process, organic waste materials are contacted with an oxidant to form a product and then an amount of the oxidant is removed from the product to form a reactor-ready feedstock. The oxidant is removed by various means, including washing, photolysis, catalytic means, oxidation of the oxidant, reduction of the oxidant, and heat. The reactor-ready feedstock may then be introduced into a reactor, such as a digester or incubator, and the reactor-ready feedstock is converted by microorganisms into biofuel or other products. | 2011-05-19 |
20110117620 | PROCESS FOR PRODUCING METHANE FROM PROCESS WATER AND BIOGENIC MATERIAL - A process for producing methane from process water and biogenic material such as that occurring in the production of sugar and ethanol, wherein at least one mixing/preliminary tank is supplied with process water and biomass, and optionally with washing and/or fresh water and/or substrate water to produce a mash, the mash is set to a suitable pH value and temperature. The mash is transferred into at least one bioreactor with anaerobic methane bacteria for biogas production, the biogas developed is extracted and the biodegraded fluid is drawn off. A biogas plant for performing this process has at least one mixing or preliminary tank for mash provided with a heat exchanger system, and at least one downstream biogas reactor having bacteria producing biogas. The biogas plant is used for producing biogas and storing waste and process water and by-products from the sugar and ethanol production operation. | 2011-05-19 |
20110117621 | Aldehyde Tags, Uses Thereof in Site-Specific Protein Modification - The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide. | 2011-05-19 |
20110117622 | SEAMLESS CAPSULE - The seamless capsule of the invention is obtained by immersing in an aqueous fluid a two-layered seamless capsule comprising an inner layer comprising a suspension composition comprising a biocatalyst suspended in an oily substance and an outer layer comprising a shell composition comprising a water permeable substance. The seamless capsule of the invention, which has a pseudo three-layer structure of outer layer/oil layer/aqueous layer, is useful in that it is applicable to, for example, a bioreactor. | 2011-05-19 |
20110117623 | DYNAMIC THERMORESPONSIVE NANOPARTICLES FOR STABILIZATION OF ENZYMES AT HIGH TEMPERATURES - The present invention provides a thermoresponsive nanoparticle useful for the stabilization of enzymes in environments having a temperature greater than thirty degrees Centigrade. The thermoresponsive nanoparticle has (a) a functionalized enzyme conjugate having one or more enzymes or biological catalysts, the enzymes or biological catalysts are modified with palmitic acid N-hydroxysuccinimide ester and acryclic acid N-hydroxysuccinimide ester, and (b) a thermally responsive polymer, wherein the functionalized enzyme conjugate is encapsulated within the thermally responsive polymer. A nanocatalyst is provided that has one or more proteins. The proteins are covalently immobilized and encapsulated within a thermally responsive polymer shell. The proteins are one or more enzymes or biological catalysts. A method for protecting the proteins is also set forth. | 2011-05-19 |
20110117624 | PROTEASES AND VARIANTS THEREOF - The present invention relates to isolated proteases of the RP-II type and variants of RP-II proteases exhibiting improved properties in comparison to the parent RP-II protease, DNA constructs and vectors coding for the expression of said proteases and variants, host cells capable of expressing the proteases and variants from the DNA constructs, as well as a method of producing them by cultivating said host cells. The proteases may advantageously be used as constituents in detergent compositions and additives, optionally in combination with other enzymes such as proteases, lipases, cellulases, amylases, peroxidases or oxidases. | 2011-05-19 |