20th week of 2016 patent applcation highlights part 38 |
Patent application number | Title | Published |
20160139071 | Gas Sensor Apparatus and Installation Structure of Gas Sensor Apparatus - To provide a gas sensor apparatus capable of preventing clogging of a gas intake port due to particles, droplets, or the like, of a gas and maintaining measurement accuracy for a long time, a gas sensor apparatus | 2016-05-19 |
20160139072 | BIOSENSOR AND MANUFACTURING METHOD THEREFOR - A biosensor and a method for manufacturing the biosensor. The biosensor comprises an insulative substrate ( | 2016-05-19 |
20160139073 | OXYGEN SENSOR CONTROL BASED ON WATER CONTACT - Various methods for operating an oxygen sensor are provided. In one example, a method of operating an oxygen sensor comprises applying power to a heater of the oxygen sensor, and indicating whether water is in contact with the oxygen sensor based on a time rate of change of a temperature of the oxygen sensor. | 2016-05-19 |
20160139074 | NITROGEN OXIDE RESPONSIVE ELEMENT AND METHOD FOR PRODUCING SAME - The present specification provides a NOx responsive element suitable for directly sensing NOx. The NOx responsive element an oxygen ion conductive layer has a first electrode layer having a nitrogen oxide decomposition catalyst phase composed of perovskite-type oxide, being in contact with the oxygen ion conductive layer, and being exposed to NOx, and a second electrode layer opposing the first electrode layer across the oxygen ion conductive layer. The nitrogen oxide decomposition catalyst phase has a nitrogen oxide adsorption stabilizing surface on its surface exposed to nitrogen oxide. | 2016-05-19 |
20160139075 | METHOD AND SYSTEM FOR HYDRATING AND CALIBRATING AN ELECTROCHEMICAL SENSOR - Methods and systems for hydrating and calibrating an electrochemical sensor are disclosed. The method comprises providing an electrochemical sensor, providing a calibration solution to a measuring chamber of the electrochemical sensor, contacting the sensor with the calibration solution within the measuring chamber, exposing the sensor and the calibration solution to an elevated temperature, and over a cooling period, cooling the sensor and the calibration solution with a tempering device, wherein the temperature is controllable within a device error range of temperature, performing a plurality of calibrations of the sensor, wherein a calibration of the plurality of calibrations is valid for a calibration margin of temperature error, the calibration margin of temperature error exceeds the device error range of temperature, and controlling a decrease of the temperature of the sensor and the calibration solution not to exceed the calibration margin of temperature error between consecutive calibrations of the sensor. | 2016-05-19 |
20160139076 | ELECTRODE-TYPE SOLUTION MEASURING APPARATUS, STORAGE CONTAINER, AND ENDOSCOPE REPROCESSOR - In an electrode unit, a working electrode and a counter electrode are disposed in a cylindrical section having a cylindrical shape, which is a sensor main body, a distal end face of the working electrode is covered with a diaphragm that allows liquid to be measure to permeate, and an internal liquid chamber in which internal liquid of an electrolyte is stored and a standard solution chamber in which a standard solution for calibration is stored are partitioned by the diaphragm. The standard solution chamber is surrounded by an inner wall of the cylindrical section and a cap. When the electrode unit is mounted on a medical solution tank, zero adjustment is automatically performed using a standard solution inside the electrode unit. Thereafter, when the cap is opened, the standard solution is discharged and measurement in an actual use can be performed. | 2016-05-19 |
20160139077 | Apparatus for Analyzing Ion Kinetics in Dielectrics - An apparatus for analyzing ion kinetics in a dielectric probe structure includes an ion reservoir abutting the dielectric probe structure and configured to supply mobile ions to the dielectric probe structure, a capacitor structure configured to generate an electric field in the dielectric probe structure along a vertical direction, and an electrode structure configured to generate an electrophoretic force on mobile ions in the dielectric probe structure along a lateral direction. A method for analyzing ion kinetics in the dielectric probe structure of the apparatus is also provided. | 2016-05-19 |
20160139078 | GRADIENT ELUTION ISOTACHOPHORETIC APPARATUS FOR SEPARATING, PURIFYING, CONCENTRATING, QUANTIFYING, AND/OR EXTRACTING CHARGED ANALYTES AND METHODS THEREOF - Gradient elution isotachophoretic apparatus, and systems for performing gradient elution isotachophoresis to separate, purify, concentrate, quantify, and/or extract charged analytes from a sample. The isotachophoretic apparatus include an electrophoretic assembly, a sampling assembly connected to the electrophoretic assembly, and/or a support structure connected to the electrophoretic assembly and/or to the sampling assembly. The system includes an isotachophoretic apparatus, and a controller communicatively coupled to the isotachophoretic apparatus. The controller includes a storage medium and a processor for executing computer readable and executable instructions. | 2016-05-19 |
20160139079 | Molecular Characterization Device - Provided is a solid state support structure including an aperture having a molecular entrance and a molecular exit. A first reservoir is in fluidic communication with the molecular entrance of the aperture and contains a molecule-bearing liquid solution. A second reservoir is in fluidic communication with the molecular exit of the aperture for containing a molecule-bearing liquid solution. A first liquid channel is connected to the first reservoir within less than about 300 microns of the aperture in the support structure and includes molecule-bearing liquid solution for delivery to the first reservoir. A second liquid channel is connected to the second reservoir for accepting molecule-bearing liquid solution from the second reservoir. An electrical connection between the first reservoir and the second reservoir imposes an electrical bias between the first reservoir and the second reservoir for driving the molecule-bearing liquid solution through the aperture in the solid state support structure. | 2016-05-19 |
20160139080 | CHARACTERIZATION OF BLOOD HEMOSTASIS AND OXYGEN TRANSPORT PARAMETERS - An integrated system for determining a hemostasis and oxygen transport parameter of a blood sample, such as blood, is disclosed. The system includes a measurement system, such as an ultrasonic sensor, configured to determine data characterizing the blood sample. For example, the data could be displacement of the blood sample in response to ultrasonic pulses. An integrated aspect of the system may be a common sensor, sample portion or data for fast and efficient determination of both parameters. The parameters can also be used to correct or improve measured parameters. For example, physiological adjustments may be applied to the hemostatic parameters using a HCT measurement. Also, physical adjustments may be applied, such as through calibration using a speed or attenuation of the sound pulse through or by the blood sample. These parameters may be displayed on a GUI to guide treatment. | 2016-05-19 |
20160139081 | SYSTEM AND METHOD FOR A NONDESTRUCTIVE TESTING OF METAL FUSION WELDS AT THIN-WALLED PIPES - The invention relates to a system for the nondestructive testing of metal fusion welds at thin-walled pipes having a maximum wall thickness of 6 mm. It is formed with at least one test probe for the emission and detection of soundwaves as well as with at least one adjustment body which is composed of a material which is the same or a material having at least approximately the same acoustic properties as the respective pipe to be tested. The outline dimensions and the diameters/thicknesses of the adjustment body are at least approximately the same as those of the respective pipe to be tested. A plurality of blind bores each having different lengths/depths starting from their openings to their bases are formed in the adjustment body. | 2016-05-19 |
20160139082 | Ultrasonic NDT Inspection System - A method and system for the ultrasonic non-destructive testing of joints in plastic pipesusing A-scans. Ahand-held ultrasonic transducer is used to perform an A-scan and a comparison made on a response from the interface region of the jointused to determine a quality of the joint. Levels of result can providea binary outputto give an indicationof whether or not a defect is present in thejoint. Comparison techniques are described. Tests for coupling efficiency and performance are described making the system useable by an unskilled technician.The system finds application in fault detection on electro-fusion welds in plastic pipe joints. | 2016-05-19 |
20160139083 | METHOD TO DETECT VIBRATION NODES BETWEEN A SENSOR AND AN ACTUATOR IN A ROTATABLE COMPONENT - A method of detecting a vibration node between a non-collocated sensor-actuator pair of a rotatable component includes applying an excitation signal to an actuator of the sensor actuator pair. The method also includes obtaining frequency response data from the sensor-actuator pair. The method further includes analyzing the frequency response data to ascertain a resonant frequency of the rotatable component. The method includes identifying a resonance/anti-resonance peak pair in the frequency response data for the non-collocated sensor-actuator pair. Furthermore, the method includes determining whether the vibration node is located between a sensor and the actuator of the non-collocated sensor-actuator pair based on the resonance/anti-resonance peak pair. | 2016-05-19 |
20160139084 | SIGNAL PROCESSING APPARATUS, SERVER, DETECTION SYSTEM, AND SIGNAL PROCESSING METHOD - According to an embodiment, a signal processing apparatus includes a receiver, a time information generator, a processor, and a communicator. The receiver receives a voltage signal from a sensor that detects an elastic wave generated from a structure. The time information generator generates time information having a bit length based on a measurement continuing time period of the structure, a propagation velocity of the elastic wave, and a position identification accuracy of a generation source of the elastic wave. The processor generates detection information in which feature amount information that indicates a feature of the voltage signal and the time information that indicates a reception time of the voltage signal are in association with each other. The communicator transmits the detection information to a server. | 2016-05-19 |
20160139085 | APPARATUS AND METHOD FOR ANALYSIS OF A FLUID SAMPLE - An method for analyzing a fluid comprises collecting a sample of the fluid and exposing the fluid sample to a light of a predetermined wavelength at a predetermined modulation frequency. An acoustic signal caused by the interaction of the light and the fluid sample is sensed, and the sensed acoustic signal is related to at least one component of the fluid. | 2016-05-19 |
20160139086 | COUPLANT AND ARRANGEMENT OF COUPLANT, TRANSDUCER, AND CONSTRUCTION COMPONENT - A couplant and an arrangement of a couplant include a transducer and a construction component. The couplant is adapted to couple the transducer to a surface of the construction component. The couplant comprises basically 15% to 75% mass portion of hard metal. | 2016-05-19 |
20160139087 | METHOD OF DETERMINING THE MAGNITUDE OF A FIELD VARIABLE OF AN ENERGY WAVE - Determining magnitude of a field variable of an energy wave through domain of interest, including steps of: defining plurality of master-particles spaced within domain, master-particles being representative of field variables of energy wave at location of respective master-particle, and defining supporting domain Ω | 2016-05-19 |
20160139088 | METHOD AND APPARATUS FOR INSPECTING A GAS SAMPLE - An apparatus for detecting a presence of at least one analyte in a gas sample. The apparatus comprises a pump for drawing a gas sample from an ambient air, a passage having first and second ends, a chamber connected to the first end and containing a concentrating element for collecting at least one analyte from the gas sample, a chromatographic separator connected to a second end of the passage, and a gas source for streaming a carrier gas via the chamber to transfer the at least one analyte toward at least one chemical detector, via the chromatographic separator, in a first direction. The pump draws the gas sample via the chamber in a second direction and the first and second directions are substantially opposing to one another. | 2016-05-19 |
20160139089 | METHOD AND APPARATUS FOR INSPECTING A GAS SAMPLE - An apparatus for detecting a presence of at least one analyte in a gas sample. The apparatus comprises a pump for drawing a gas sample from an ambient air, a passage having first and second ends, a chamber connected to the first end and containing a concentrating element for collecting at least one analyte from the gas sample, a chromatographic separator connected to a second end of the passage, and a gas source for streaming a carrier gas via the chamber to transfer the at least one analyte toward at least one chemical detector, via the chromatographic separator, in a first direction. The pump draws the gas sample via the chamber in a second direction and the first and second directions are substantially opposing to one another. | 2016-05-19 |
20160139090 | METHOD AND DEVICE FOR RECEIVING A DROPLET - The present invention relates to a droplet receiver, comprising a receptacle for receiving a droplet, a fluid conduit connected at a first end thereof to the droplet receptacle thereby providing a course within which the droplet received in the droplet receptacle moves, the conduit at its distal end in communication with a reservoir,and a fluid layer wetting the internal walls of the receptacle and conduit in such a way as permit reception of the droplet without loss of the received droplet due to wetting of the internal receptacle and conduit walls. | 2016-05-19 |
20160139091 | TRAPS FOR USE WITH CHROMATOGRAPHY SYSTEMS - Certain configurations are provided herein of a trap that can be used with chromatography systems. In certain instances, the trap may be designed to remove substantially all oil in a sample comprising the oil and an analyte of interest. Methods using the gravity trap are also described. | 2016-05-19 |
20160139092 | CARBON DIOXIDE LIQUID PHASE FORMING USING HIGH VOLUME HEAD DISPLACEMENT - Systems and methods for pumping carbon dioxide in a chromatography system include an actuator that receives and compresses carbon dioxide at or above room temperature at a given pressure to put the carbon dioxide in or near supercritical form. This actuator can be a pre-pump disposed on the intake side of a pumping system. Alternatively, this actuator can be a primary actuator in the pumping system. The actuator includes an intake chamber that receives the carbon dioxide and a movable plunger extending into and closely received by the intake chamber. The plunger has a diameter and stroke length adapted to compress the carbon dioxide received by the intake chamber in sufficient volume at the given pressure to put the carbon dioxide in or near supercritical form at or above room temperature. A metered amount of the carbon dioxide in or near supercritical form can then be pumped. | 2016-05-19 |
20160139093 | HPLC SAMPLE INTRODUCTION WITH COUPLING SAMPLE RESERVOIRS IN PARALLEL BETWEEN MOBILE PHASE DRIVE AND SEPARATION UNIT - Disclosed is a sample dispatcher configured for individually introducing a plurality of portions of one or more sample fluids into a flow of a mobile phase of a separation system configured for separating compounds of the sample fluids. The separation system comprises a mobile phase drive configured for driving the mobile phase through a separation unit configured for separating compounds of the sample fluids in the mobile phase. The sample dispatcher comprises a plurality of sample reservoirs, each configured for receiving and temporarily storing a respective sample fluid portion or at least a part thereof. The sample dispatcher is configured for selectively coupling one of the plurality of sample reservoirs between the mobile phase drive and the separation unit, and further for coupling at least two of the plurality of sample reservoirs in parallel between the mobile phase drive and the separation unit. | 2016-05-19 |
20160139094 | MULTI-POSITION, MICRO-FLUIDIC VALVE ASSEMBLY WITH MULTIPLE RADIAL GROOVES TO ENABLE INDIVIDUAL OR COMBINED FLOWS - A rotary shear valve having a rotor device and a stator device both with planar faces. The stator face includes a central port located at a common rotational axis, a second port radially spaced a radius R | 2016-05-19 |
20160139095 | SYSTEMS AND METHODS OF COMPENSATION FOR CHROMATOGRAPHY COLUMN VOLUME VARIATIONS - Provided are systems and methods for adapting to volume variations in microfluidic chromatography columns. A column is calibrated by comparing a parameter of the column with a same parameter of a reference column and generating, by a processor, an adjustment factor in response to the comparison between the parameter of the column with a same parameter of the reference column. Volume differences between the calibrated column and the reference column are compensated for by integrating the generated adjustment factor into a sample separation involving the calibrated column. | 2016-05-19 |
20160139096 | Method And Apparatus Determining An Amount of Phosphine (PH3) In An Atmosphere of An Enclosed Area - A process is provided for determining the amount of phosphine gas in the atmosphere of an enclosed area that has been fumigated with phosphine (PH | 2016-05-19 |
20160139097 | METHOD FOR VERIFYING CORRECT FUNCTION OF SAMPLING EQUIPMENT - The invention relates to methods for verification of correct function of sampling equipment is disclosed, wherein said method comprises the steps of: a) providing a pump assembly ( | 2016-05-19 |
20160139098 | MEASUREMENT APPARATUS - A measurement apparatus includes a plurality of modules and a main unit for collecting measurement data output from the modules. The housing of the main unit can be carried by a user of the measurement apparatus, and the plurality of modules are removably accommodated in the housing. A CAN I/F circuit of the main unit collects the measurement data output from the module accommodated in the housing. A main CPU of the main unit outputs the collected measurement data to, for example, a personal computer connected to the main unit. An internal memory and a USB memory connected to a USB memory module store the collected measurement data. | 2016-05-19 |
20160139099 | AUTOMATED MACHINE AND METHOD FOR FRUIT TESTING - An improved fruit tester and method provides a plunger intrusion-type mechanism, a precision scale and an associated computer for control of the mechanism and for recordation, presentation and analysis of data sensed by the mechanism. An electrically powered variable speed motor carries an optical encoder to sense rotary direction and speed data, which is transmitted through circuitry to an associated computer for analysis to determine control data to maintain pre-programmed motor function. Computer software determines plunger position and resultant penetration into a fruit at either pre-determined plunger speed or constant plunger resistive pressure in fine increments over the plunger trajectory and stores this data in computer memory. The precision scale is used to determine the weight of the fruit before and after the penetration tests and the difference in weight is used to automatically calculate the Specific juice Content (SJC) of the fruit. | 2016-05-19 |
20160139100 | METHOD FOR CONTROLLING A DISINFECTION STATUS OF A TEMPERATURE CONTROL DEVICE AND TEMPERATURE CONTROL DEVICE FOR HUMAN BODY TEMPERATURE CONTROL DURING EXTRACORPOREAL CIRCULATION - The present application relates to a method for controlling a disinfection status of a heater and/or cooler for human body temperature control during extracorporeal circulation. The temperature control is conducted by use of a heat exchanger and a temperature control liquid circulating through the heat exchanger and the heater and/or cooler. The inventive method comprises using a long term disinfectant in the temperature control liquid, measuring and preferably recording the concentration of the disinfectant in the temperature control liquid and deducing a disinfectant status of the temperature control liquid from the measured concentration of the disinfectant in the temperature control liquid. | 2016-05-19 |
20160139101 | SUBMERSIBLE MULTI-PARAMETER SONDE HAVING A HIGH SENSOR FORM FACTOR SENSOR - Provided are multi-parameter sonde systems having a unique form-factor, wherein the plurality of sensors are arranged in a tight-fit configuration. This provides a single distal sensing surface and minimal separation distance between adjacent sensors. The sensors may be pie shaped with an interlocking feature to tightly hold the sensors together, with a sensor guard disposed over the outer surface of the interlocked sensors. Sensor-guards disclosed herein may have an integrated sensor storage and sensor guard configuration, thereby avoiding a need for a separate storage cup and that are configured to minimize unwanted biological growth. Also provided are uniquely shaped individual sensors having interlocking features to hold several sensors together in a sonde. | 2016-05-19 |
20160139102 | PAPER MICROFLUIDIC DEVICES FOR DETECTION OF IMPROVISED EXPLOSIVES - Paper microfluidic devices for testing for explosives are provided, along with methods of fabricating and using the same. One or more channels are formed on a paper substrate, and a test spot is formed in at least one of the channels. The channels can be hydrophobic. A test reagent is provided in the test spot and tests for explosives. | 2016-05-19 |
20160139103 | OIL IDENTIFICATION SYSTEM - An oil identification system is disclosed. The oil identification system includes a parameter sensor coupled to at least one of an oil pan or an oil flow path of a machine. The oil identification system also includes an identification module. The identification module is also configured to receive a signal indicative of movement of charged particles in the oil of the at least one of the oil pan or the oil flow path. The identification module is further configured to determine a resistivity of the oil in the at least one of the oil pan or the oil flow path. The identification module is configured to compare the resistivity of the oil with resistivity data readings. The identification module is also configured to identify a type of oil in the at least one of the oil pan or the oil flow path based on the comparison. | 2016-05-19 |
20160139104 | Fluid Quality Monitoring and Filtration System - A fluid filtration system may include a fluid filter assembly that includes a filter element configured to filter a fluid and a sensor probe incorporated into the fluid filter assembly. The sensor probe may include a chemically reactive material sensitive to at least one property of the fluid and at least a portion of the sensor probe may be exposed to the fluid. | 2016-05-19 |
20160139105 | DNA SEQUENCING USING MULTIPLE METAL LAYER STRUCTURE WITH DIFFERENT ORGANIC COATINGS FORMING DIFFERENT TRANSIENT BONDINGS TO DNA - A nanodevice includes a reservoir filled with conductive fluid and a membrane separating the reservoir. A nanopore is formed through the membrane having electrode layers separated by insulating layers. A certain electrode layer has a first type of organic coating and a pair of electrode layers has a second type. The first type of organic coating forms a motion control transient bond to a molecule in the nanopore for motion control, and the second type forms first and second transient bonds to different bonding sites of a base of the molecule. When a voltage is applied to the pair of electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels via the first and second transient bonds formed to be measured as a current signature for distinguishing the base. The motion control transient bond is stronger than first and second transient bonds. | 2016-05-19 |
20160139106 | APPARATUS AND METHOD FOR BLOOD ANALYSIS - Provided is an apparatus for blood analysis. The apparatus for blood analysis includes a spin coater to which blood is supplied, a light source part emitting light onto the spin coater, a measurement part detecting light reflected from the blood on the spin coater, and outputting a detected signal, and an analysis part analyzing information on the blood from the detected signal from the measurement part. | 2016-05-19 |
20160139107 | CENTRIFUGE - A centrifuge is provided. The centrifuge includes a power source, the power source configured to generate electrical power from a renewable power source. At least one battery electrically coupled to the power source. A motor is electrically coupled to the at least one battery. A rotor is coupled to the motor. The rotor has a generally cylindrical body and a pair of opposing openings opposite the motor, and a pair of holders each disposed in one of the pair of opposing openings, each of the holders having an opening on one end sized to receive a capillary tube. | 2016-05-19 |
20160139108 | SYSTEM AND METHOD FOR CONTROLLING A FLOW THROUGH A PNEUMATIC SYSTEM - A device, system and method related to a pneumatic system for fluid analysis. The device, system and method comprises a connection interface for a fluid analyser unit, a connection interface for a pump unit, a flow sensor and a pressure sensor. The device, system and method further comprises control unit for calculating a pump stroke force or amplitude, and/or pump frequency based on measurements from the flow sensor and the pressure sensor for obtaining a constant flow through the pneumatic system. | 2016-05-19 |
20160139109 | A Method of Determining or Predicting a Characteristic of a Cell - A method of determining or predicting a characteristic of a query cell, for example the identity of the query cell, is described. The method comprises the steps of incubating the query cell with a plurality of chemical cell stressor molecules, determining the growth response of the query cell in the presence of each of the at least three chemical cell stressor molecules to generate a query cell-specific growth response fingerprint, and comparing the query cell-specific growth response fingerprint with one or more reference cell-specific growth response fingerprints corresponding to one or more cells having known characteristics. The characteristic of the cell (for example the identity of the cell) may be determined based on the level of correlation between the query cell-specific growth response fingerprint and the one or more reference cell-specific growth response fingerprints. | 2016-05-19 |
20160139110 | FLUID CHANNEL SYSTEM FOR EXAMINING CELLS - A fluid channel system for examining cells may comprise a chamber filled with at least one photopolymerized hydrogel and/or one polymerized photodepolymerizable hydrogel to at least 90% capacity. The chamber may open exclusively towards at least one fluid channel via at least two openings. The at least one fluid channel and the chamber may each be in the form of a hollow space in a substrate, and each fluid channel may have two openings to the outside. In an embodiment, the system may comprise a hollow space in a substrate with at least one photopolymerized hydrogel and/or one polymerized photodepolymerizable hydrogel may be arranged and structured such that at least one fluid channel and a coherent hydrogel structure are formed. The hydrogel structure may adjoin the at least one fluid channel at two separate surface areas and connect to the outside exclusively via the at least one fluid channel. | 2016-05-19 |
20160139111 | SCREENING METHODS FOR COGNITIVE ENHANCERS - The present invention provides methods for identifying cognitive enhancers able to enhance CREB pathway function. Cognitive enhancers identified in accordance with the invention can be used in rehabilitating an animal with cognitive dysfunction and for enhancing memory or normal cognitive performance (ability or function) in the animal. | 2016-05-19 |
20160139112 | MECHANISM AND DRUG TARGETS FOR REDUCING CELL EDEMA (NEUROPROTECTION) AND CYTOPLASMIC EXCITABILITY IN ASTROCYTES IN NORMAL AND PATHOLOGICAL STATES - The present invention pertains to a method for screening a compound useful in reducing astroglial edema, said method comprising: (i) providing a compound; (ii) bringing said compound in contact with an astrocyte; and (iii) determining the cAMP level in said astrocyte contacted with said compound; wherein said compound is identified as a compound useful in reducing astroglial edema, if the cAMP level in the astrocyte increases after contact. The present invention further pertains to an agent elevating the cAMP level in astrocytes for use in reducing astroglial edema. | 2016-05-19 |
20160139113 | Methods and Compositions for Phototransfer - Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through a photocleavable linker are put in proximity (or contact) with a second surface, and then phototransferred to the second surface upon exposure to electromagnetic radiation. Illuminating the compound with radiation photocleaves the compound from the first surface and transfers the compound to the second surface. | 2016-05-19 |
20160139114 | Rapid Test for Detecting Pathogen Material, in Particular in Order to Support the Diagnosis of Sepsis, and Kit and Device for Performing a Sepsis Test - A rapid test is provided for detecting pathogenic material, particularly for supporting the diagnosis of sepsis, as well as a kit and a device for the implementation of a sepsis test. | 2016-05-19 |
20160139115 | DEVICE FOR USE IN THE DETECTION OF BINDING AFFINITIES | 2016-05-19 |
20160139116 | IN VITRO CAPTURE AND ANALYSIS OF CIRCULATING TUMOR CELLS - This invention provides methods and compositions for capturing circulating tumor cells (CTCs) as well as various divergent CTC phenotypes using seprase-specific affinity reagents. Methods of analyzing CTCs and assessing their metastatic potential in vivo and in vitro are also disclosed. | 2016-05-19 |
20160139117 | METHOD FOR PREDICTING POST-THERAPY PROGNOSIS OF RELAPSING-REMITTING MULTIPLE SCLEROSIS (RRMS) PATIENT, AND METHOD FOR DETERMINING APPLICABILITY OF NOVEL THERAPY - According to the present invention, the amount of a plasmablast (PB) in a sample of a relapsing-remitting multiple sclerosis (RRMS) patient can be measured, thereby predicting the therapeutic effect of interferon beta (IFN-β) or predicting a RRMS case for which the continuous administration of IFN-β is difficult due to the manifestation of a serious adverse reaction or the aggravation of concomitant immune disorder. In addition, the amount of PB in a sample of a RRMS patient can also be measured, thereby predicting the therapeutic effect of an IL-6 inhibitor in the treatment of RRMS. As a result, a treatment method effective for patients not suitable for IFN-β in the treatment of RRMS can be provided. | 2016-05-19 |
20160139118 | NOVEL ASSAY - The present invention relates to a CFI bioactivity assay designed to quantitatively measure (a) CFI bioactivity of plasma or other body fluids; and (b) bioactivity of CFI in plasma or other body fluids of a human patient afflicted by a disease that involves amyloid deposition in tissues, in particular Alzheimer disease, AMD, glaucoma, or beta-amyloid cataract formation. | 2016-05-19 |
20160139119 | METHOD OF DETECTING THE PRESENCE OR ABSENCE OF AUTOANTIBODIES - The invention relates to methods of detecting the presence or absence of autoantibodies in an individual and to related methods and kits. | 2016-05-19 |
20160139120 | RAGE AS A C1Q RECEPTOR, METHODS AND APPLICATIONS - A method of identifying a compound capable of reducing or increasing the amount of the receptor for RAGE-C1q Binding comprising a) providing an amount of the compound to be tested; b) contacting the amount of the compound with C1q and RAGE; c) measuring the amount of RAGE-C1q binding in step b); d) comparing the amount of RAGE-C1q binding measured in step c) with the amount of RAGE-C1q binding measured under corresponding conditions in the absence of the compound; and e) identifying the compound as capable of reducing or increasing the amount of RAGE-C1q binding. The present invention also provides a method of treating a subject suffering from a RAGE-related disorder comprising administering to the subject a therapeutically effective amount of a compound that is a modulator of the amount of RAGE-C1q binding so as to thereby treat the subject. | 2016-05-19 |
20160139121 | Methods for Assaying Cellular Binding Interactions - There are provided methods, and devices for assaying for a binding interaction between a protein, such as a monoclonal antibody, produced by a cell, and a biomolecule. The method may include retaining the cell within a chamber having an aperture; exposing the protein produced by the cell to a capture substrate, wherein the capture substrate is in fluid communication with the protein produced by the cell and wherein the capture substrate is operable to bind the protein produced by the cell; flowing a fluid volume comprising the biomolecule through the chamber via said aperture, wherein the fluid volume is in fluid communication with the capture substrate; and determining a binding interaction between the protein produced by the cell and the biomolecule. | 2016-05-19 |
20160139122 | MARKERS FOR LONG-TERM KIDNEY GRAFT DYSFUNCTION - An in vitro method for determining the risk of occurrence of long-term kidney graft dysfunction in a subject comprising: a) measuring the level of CD8 | 2016-05-19 |
20160139123 | Shear Wave Imaging Method and Installation for Collecting Information on a Soft Solid - The invention relates to methods comprising a step consisting of determining the proportion and/or the level of T regulatory lymphocytes with a CD4 | 2016-05-19 |
20160139124 | METHOD TO BIOENGINEER DESIGNER PLATELETS USING GENE EDITING AND STEM CELL METHODOLOGIES - A method of creating cells expressing specific platelet alloantigens is disclosed. In one embodiment, the method comprises the steps of (a) combining one or more guide RNAs targeting within a platelet alloantigen target locus; (b) adding a repair template comprising a mutation in the target locus flanked by a homology arm on each side, wherein the template may additionally include a diagnostic restriction enzyme site at the target locus; (c) ligating the guide sequence of step (b) into a plasmid which also expresses a nuclease and, optionally, a selectable marker or a reporter gene; (d) transfecting pluripotent cells with the plasmid of step (c) in the presence of an HDR repair oligo; (e) cloning and testing the resulting reporter positive clones for expression of the alloantigen target of interest; and (f) culturing the resulting cells to expand their numbers or to create a differentiated cell type of interest. | 2016-05-19 |
20160139125 | IMMUNOCHROMATOGRAPHY DEVICE FOR DETECTING RSV - The present invention provides an easy-to-use and higher-sensitivity immunochromatography device for an RSV, the device using an antibody that binds specifically to F protein of the RSV in a determination region of a chromatography medium, a test kit by an immunochromatography method, and a method for detecting an RSV using these device and kit. The present invention relates to an immunochromatography device in which not only an antibody that binds specifically to F protein of an RSV but also an antibody that binds specifically to N protein of the RSV is solid-phased in a determination region of a chromatography medium. The present invention also relates to a test kit by an immunochromatography method, and a method for detecting an RSV using these device and kit. | 2016-05-19 |
20160139126 | METHOD FOR THE PROGNOSIS AND TREATMENT OF CANCER METASTASIS - The present invention relates to a method for the prognosis of bone metastasis in triple negative (including basal-like) breast cancer or, alternatively, ER+ breast cancer (including luminal A and B) which comprises determining if the c-MAF gene is amplified in a primary tumor sample. Likewise, the invention also relates to a method for determining the tendency to develop bone metastasis with respect to metastasis in other organs, which comprise determining the c-MAF gene expression level, amplification or translocation. The invention also relates to a method for predicting early bone metastasis in a subject suffering breast cancer. The invention also relates to a c-MAF inhibitor as therapeutic agent for use in the treatment of triple negative (including basal-like) breast cancer metastasis or, alternatively, ER+ breast cancer (including luminal A and B) metastasis. The invention relates to kits for predicting bone metastasis and predicting the clinical outcome of a subject suffering from bone metastasis. Finally, the invention relates to a method for typing of a subject suffering breast cancer and for classifying a subject from breast cancer into a cohort. | 2016-05-19 |
20160139127 | ONCOGENE ASSOCIATED WITH HUMAN CANCERS AND METHODS OF USE THEREOF - The present invention provides methods of treating cancer by inhibiting MECP2 and identifying cancers that will respond to therapy using MECP2 as a biomarker. | 2016-05-19 |
20160139128 | METHODS AND MATERIALS FOR TREATING RENAL CELL CARCINOMA - This document provides methods and materials related to treating renal cell carcinoma. For example, methods and materials for assessing a cancer patient (e.g., a renal cell carcinoma patient) for tumor or peritumoral tissue containing CD14 | 2016-05-19 |
20160139129 | BIOMARKERS FOR THE DIAGNOSIS AND THE RESPONSE TO TREATMENT OF PANCREATIC CANCER - The invention related to biomarkers, a method and a kit for early diagnosis of pancreatic cancer, in particular of pancreatic ductal adenocarcinoma (PDAC); and to biomarkers, a method and a kit or device for predicting or prognosticating an individual's response to combination treatment with a nucleoside analogue (preferably gemcitabine) and with a growth factor receptor (preferably erlotinib) in patients with pancreatic ductal adenocarcinoma. | 2016-05-19 |
20160139130 | DETECTING CANCER WITH ANTI-CXCL16 AND ANTI-CXCR6 ANTIBODIES - Methods for detecting cancer or monitoring cancer progression in a subject are disclosed. The method includes detecting the level of expression of one or more cancer markers in a biological sample obtained from the subject; and comparing the level of expression of the one or more cancer markers in the biological sample to a normal level of expression of the one or more cancer markers. The one or more cancer markers comprises CXCL16 or CXCR6 or both CXCL16 and CXCR6. Also disclosed is a kit for detecting cancer or monitoring cancer progression. | 2016-05-19 |
20160139131 | ANTIBODIES RECOGNIZING A CARBOHYDRATE CONTAINING EPITOPE ON CD-43 AND CEA EXPRESSED ON CANCER CELLS AND METHODS USING SAME - The present invention provides novel antibodies specifically bind to an epitope on CD43 and CEA expressed on nonhematopoietic cancer cells, but do not specifically bind to a CD43 expressed by a leukocyte or by a Jurkat cell, and is capable of inducing apoptosis of the nonhematopoietic cancer cell after binding to the epitope on cell surface of the nonhematopoietic cancer cell in the absence of cytotoxin conjugation and immune effector function, wherein the epitope comprises a carbohydrate structure and the binding of the antibody to the epitope is inhibited by a carbohydrate comprising a Le | 2016-05-19 |
20160139132 | Method of Diagnosis or Prognosis of a Neoplasm Comprising Determining the Level of Expression of a Protein in Stromal Cells Adjacent to the Neoplasm - The invention provides diagnostic and therapeutic methods for neoplastic disease patients with neoplasms of, for example, the breast, skin, kidney, lung, pancreas, rectum and colon, prostate, bladder, epithelial, non-epithelial, lymphomas, sarcomas, melanomas, and the like, wherein the method comprises determining the level of expression of cavcolin-1, cavcolin-2, vimentin, calponon2, tropomyosin, gelsolin, prolyl 4-hydroxylase alpha, EF-I-delta, or M2-isoform of pyruvate kinase in stromal cells adjacent to the neoplasm. | 2016-05-19 |
20160139133 | DESIGN, SYNTHESIS AND USE OF SYNTHETIC NUCLEOTIDES COMPRISING CHARGE MASS TAGS - Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced. | 2016-05-19 |
20160139134 | METHOD FOR ANALYSIS OF COMPOUNDS WITH AMINO GROUP AND ANALYTICAL REAGENT THEREFOR - The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino group is labeled with a specific carbamate compound such as p-trimethylammonium anilyl-N-hydroxysuccinimidyl carbamate iodide to enhance the selectivity and sensitivity. The present invention is preferably used in conjunction with mass spectrometry such as MS/MS method to facilitate quantitative analysis. The present invention further provides labeling reagents for mass spectrometry. | 2016-05-19 |
20160139135 | Optically-Detectable Enzyme Substrates and Their Method of Use - The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a β-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a β-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a β-lactmase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a β-lactmase or instructions for using the components in an assay. | 2016-05-19 |
20160139136 | RAPID FLUORESCENCE TAGGING OF GLYCANS AND OTHER BIOMOLECULES WITH ENHANCED MS SIGNALS - Reagents comprising MS active, fluorescent molecules with an activated functionality for reaction with amines useful in tagging biomolecules such as N-glycans and uses thereof are taught and described. | 2016-05-19 |
20160139137 | RATIOMETRIC ASSAY FOR HYDROLYTIC ENZYME QUANTIFICATION - The invention refers to a nanoparticle comprising (i) a core comprising a first population of quantum dots (QDs) embedded in silica, (ii) a shell comprising a second population of QDs embedded in silica, (iii) at least one biomolecule selected from a peptide, a nucleic acid, a carbohydrate or a lipid which comprises a cleavage site that is susceptible of being cleaved by a hydrolytic enzyme, said biomolecule being bound to the surface of the shell through a moiety, and (iv) a photoluminescent label for each biomolecule, wherein the label is bound to the part of the biomolecule which detaches from the nanoparticle after cleavage of said biomolecule by a hydrolytic enzyme, wherein the first and second QD populations have different maximum photoluminescence emission wavelengths, and only the second QD population is susceptible of producing Forster resonance energy transfer (FRET) with the photoluminescent label. | 2016-05-19 |
20160139138 | MODULAR POINT-OF-CARE DEVICES, SYSTEMS, AND USES THEREOF - The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications. | 2016-05-19 |
20160139139 | Systems and Methods for Developing Diagnostic Tests Based on Biomarker Information from Legacy Clinical Sample Sets - Disclosed are systems and methods for developing diagnostic tests (e.g., detection, screening, monitoring, and prognostic tests) based on biomarker information from legacy clinical sample sets, for which only small sample volumes (e.g., about 0.05 to about 1.0 mL or less per sample) are typically available. For example, biomarkers (e.g., about 10, 50, 100, 150, 200, 300, or more) may be detected in the clinical samples through the use of single molecule detection and each biomarker may be detected in an assay that includes about 1 μL. or less of a legacy clinical sample. | 2016-05-19 |
20160139140 | MASS LABELS - The present invention provides set of two or more mass labels, wherein each mass label in the set has the same integer mass as every other label in the set, and each mass label in the set has an exact mass which is different to the mass of all other mass labels in the set such that all the mass labels in the set are distinguishable from each other by mass spectrometry. | 2016-05-19 |
20160139141 | IMAGING MASS CYTOMETRY USING MOLECULAR TAGGING - Methods of imaging a biological sample by mass cytometry using molecular tagging are disclosed. | 2016-05-19 |
20160139142 | METHODS FOR MEASURING THE METABOLISM OF NEURALLY DERIVED BIOMOLECULES IN VIVO - The present invention relates to methods of diagnosing, monitoring, and assessing treatment effects for neurological and neurodegenerative diseases and disorders, such as Alzheimer's Disease, early in the course of clinical disease or prior to the onset of brain damage and clinical symptoms. Methods of measuring the in vivo metabolism of biomolecules produced in the CNS in a subject are provided. | 2016-05-19 |
20160139143 | DETECTING TARGETS USING MASS TAGS AND MASS SPECTROMETRY - Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses. Mass codes produced by ionizing the mass tags are detected and/or quantified using mass spectrometry. The method can be used for multiplexed detection of multiple targets in a particular sample. In some embodiments, a map divided into sections representing sections of the tissue sample may be prepared, with the map sections including data corresponding to quantification data wherein the size of a mass peak is determined and correlated with the amount of a target for the corresponding tissue sample section. | 2016-05-19 |
20160139144 | ASSAYS FOR DETECTION OF PHENYLALANINE AMMONIA-LYASE AND ANTIBODIES TO PHENYLALANINE AMMONIA-LYASE - Provided herein are methods of detecting the presence of a pegylated enzyme, an enzyme-specific antibody (e.g., a neutralizing antibody or of a particular isotype), or a polyethylene glycol (PEG)-specific antibody in a sample, such as a bodily fluid or tissue of a patient. In certain embodiments, the enzyme is phenylalanine ammonia-lyase (PAL), such as | 2016-05-19 |
20160139145 | DIAGNOSTIC BLOOD TEST FOR SARCOIDOSIS - Sarcoidosis is a multisystem disease characterized by granulomatous inflammation in affected organs. The present invention discloses kits and a system for a blood test using mycobacterial catalase-peroxidase that has a high positive predictive value for confirming a diagnosis of sarcoidosis. | 2016-05-19 |
20160139146 | GI PROTEIN PHOSPHORYLATION AS MARKER FOR SCOLIOSIS AND SCOLIOSIS PROGRESSION, METHODS OF INCREASING GIPCR SIGNALING IN SCOLIOTIC SUBJECTS - Methods of stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's Giα protein serine phosphorylation profile and/or the degree of imbalance in G-protein coupled receptor responses to Giα and Gsα protein stimulation. In some embodiments, the methods involve detecting or determining the level of serine phosphorylated Giα1 and/or Giα3 proteins in the cell sample, and/or determining a ratio between the response to Giα protein stimulation and the response to Gsα protein stimulation from a biological sample from the subject. Methods for predicting the risk of an AIS subject for developing a severe scoliosis, for predicting the subject's responsiveness to bracing treatment, and for identifying therapeutically useful compounds are also provided, as well as kits therefor. | 2016-05-19 |
20160139147 | Method for Aiding Differential Diagnosis of Stroke - The present invention provides a method of aiding the differential diagnosis of haemorrhagic stroke, ischemic stroke and a transient ischemic attack in a patient who has suffered or is suffering a stroke. The method comprises: (i) determining the concentration of the biomarkers VCAM-1, GFAP and CRP in an ex vivo sample obtained from the patient; and (ii) establishing the statistical significance of the concentration of the biomarkers. Optionally, the method further comprises steps of (iii) determining the concentration of the biomarkers IL-6 and sTNFR1 in an ex vivo sample obtained from the patient; (iv) determining the gender of the patient; and (v) establishing the statistical significance of the concentration of the five biomarkers, in conjunction with the patient's gender. The present invention also provides substrates comprising probes for VCAM-1, GFAP and CRP for use in a method for aiding the differential diagnosis of stroke. | 2016-05-19 |
20160139148 | PATHWAY SPECIFIC MARKERS FOR DIAGNOSING IRRITABLE BOWEL SYNDROME - The present invention provides methods for aiding in the diagnosis of irritable bowel syndrome (IBS) in an individual. In particular, the present invention is useful for determining whether the individual does not have either celiac disease or inflammatory bowel disease (IBD), and has IBS and/or a subtype thereof. Thus, the present invention provides an accurate diagnostic prediction of IBS and is useful for guiding treatment decisions. | 2016-05-19 |
20160139149 | CHI3L1 FOR THE DETECTION AND TREATMENT OF NONALCOHOLIC STEATOHEPATITIS - Disclosed herein are compositions and methods for detecting nonalcoholic steatohepatitis (NASH) measuring CHI3L1 levels. In some embodiments, the methods described herein can distinguish NASH from nonalcoholic fatty liver disease. CHI3L1 levels can also be used to monitor treatment progress in patients having NASH. Also disclosed herein are compositions and methods for treating NASH by targeting CHI3L1. | 2016-05-19 |
20160139150 | METHODS FOR DIAGNOSING AND ASSESSING NEUROLOGICAL DISEASES - The present invention provides methods for diagnosing a neurological disease in a subject, screening for or assessing the risk of developing a neurological disease in a subject, monitoring progression of a neurological disease in a subject, assessing efficacy of a therapy for a neurological disease in a subject, and identifying a subject suffering from a neurological disease that may be successfully treated by an agent that affects levels of a biomarker such as a tau protein or an amyloid beta. The methods generally feature (a) obtaining a cerebrospinal fluid (CSF) sample from a subject; (b) providing a cerebrospinal fluid (CSF) correction factor for CSF obtained from a subject for at least one biomarker; and (c) determining whether the biomarker is present in elevated amounts or concentrations in the cerebrospinal fluid (CSF) sample. The neurological disease may be, for instance, impaired cognition or dementia such as Alzheimer's Disease (AD) or Mild Cognitive Impairment (MCI). The biomarker may be a tau protein such as P-tau | 2016-05-19 |
20160139151 | METHODS AND COMPOSITIONS RELATING TO NEURODEGENERATIVE DISEASES - The present invention provides a method for diagnosing or assessing a neurodegenerative disease in a test subject, comprising: (i) providing a protein-containing sample that has been obtained from the test subject; (ii) determining the concentration, amount or degree of expression of at least one specific protein isoform and/or glycoform derived from a protein biomarker selected from the group consisting of: clusterin precursor; apolipoprotein A-IV precursor; apolipoprotein C-III precursor; transthyretin; galectin 7; complement C4 precursor; alpha-2-macroglobulin precursor; Ig alpha-1 chain C; histone 2B; Ig lambda chain C region; fibrinogen gamma chain precursor; complement factor H; inter-alpha-trypsin heavy chain H4 precursor; complement C3 precursor; gamma or beta actin; haptoglobin precursor; and the serum albumin precursor, or a fragment thereof; (iii) comparing said concentration, amount or degree determined in (ii) with a reference from a control subject with a specific neurodegenerative disease, dementia or stage of disease, or from a control subject that does not have a neurogenerative disease or dementia; and (iv) based on the level of the at least one specific protein isoform and/or glycoform of the protein biomarker in the test subject relative to the reference, making a diagnosis or assessment as to the presence of and/or stage of neurodegenerative disease or dementia of the test subject. Also provided are related products and systems for use in such a method. | 2016-05-19 |
20160139152 | Biosensor Using Cell That Expresses Chemosensory Receptor That Can Detect Sugar, And Alzheimer's Disease Diagnostic Apparatus Comprising Same - The present invention relates to a biosensor that uses a cell that expresses a chemosensory receptor that can detect sugar, and an Alzheimer's disease diagnostic apparatus comprising the same. The biosensor and the Alzheimer's disease diagnostic apparatus of the present invention can sensitively detect a particular sugar in a sample, more inexpensively and more quickly, by fixing a drosophila cell having an over-expressed target sensory receptor protein on the cell surface through genetic engineering, and can thereby be efficaciously used for diagnosing Alzheimer's disease. | 2016-05-19 |
20160139153 | BIOMARKERS FOR SEIZURES - The application relates to markers for seizures and epilepsy. Polypeptide expression panels or arrays are provided, comprising one or more probes capable of binding specific polypeptides in blood plasma or blood serum of a mammalian subject. Also provided are methods for detecting seizure, methods for predicting seizure, use of sICAM-5 in the treatment of seizure, methods for assessing the effectiveness of a treatment of seizure, and diagnostic kits. | 2016-05-19 |
20160139154 | METHODS FOR DETERMINING TOTAL BODY SKELETAL MUSCLE MASS - The present invention is based on the finding that enrichment of isotope-labeled creatinine in a urine sample following oral administration of a single defined dose of isotope-labeled can be used to calculate total-body creatine pool size and total body skeletal muscle mass in a subject. The invention further encompasses methods for detecting creatinine and isotope-labeled creatinine in a single sample. The methods of the invention find use, inter alia, in diagnosing disorders related to skeletal muscle mass, and in screening potential therapeutic agents to determine their effects on muscle mass. | 2016-05-19 |
20160139155 | Method for determining mutateable ligand-GPCR binding at single amino acid resolution and pairs of mutated ligand and GPCR - Method of determining GPCR and mutatable ligand binding ability, includes providing a well microtiter plate with well array having rows and columns, GPCR or rhodopsin in wells, and parent ligand mutant binding to GPCR when GPCR resides in conformation, contacting parent ligand mutants in wells with GPCR, coupling parent ligand to GPCR, and determining mutant ligand binding strength compared to standard parent ligand and GPCR by determining coupled mutant-GPCR complex in wells. Rhodopsin binding 403 mutants covering arrestin sequence provides functional 4th dimension arrestin crystal structures. Resulting single amino acid resolution functional maps reveal critical interactions in arrestin polar core and C-tail interrupted during activation. Amino acid patches reduce binding and act as direct binding rhodopsin interfaces. This and computational molecular docking active arrestin4 and light-activated rhodopsin develop arrestin-rhodopsin complex model. Combined mutants allow binding affinity modification and GPCR-ligand complex stability for diagnostics or intervention. | 2016-05-19 |
20160139156 | APPARATUSES, METHODS, AND SYSTEMS FOR HOME MONITORING OF PHYSIOLOGICAL STATES AND CONDITIONS - Methods, systems and apparatuses for monitoring a physiological condition of a user. The apparatus includes a housing, a processor, a power source, a receptacle configured to receive an inserted test strip, an imaging unit configured to image the inserted test strip, and a communication unit configured to communicate data received from the imaging unit to a communication network. The apparatus is configured to read color change results produced by more than one different type test strip, and the more than one different type of test strip each produce a different color to indicate the presence of an analyte. The apparatus may include two separate but connectable units: an analyte sensing unit and a base unit. The apparatus may further include a temperature sensing unit which may alternatively connect with the base unit. The apparatus may communicate with a mobile application on a hand held device. | 2016-05-19 |
20160139157 | METHODS FOR DETECTING VITAMIN D METABOLITES BY MASS SPECTROMETRY - Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay. | 2016-05-19 |
20160139158 | FLUOROGENIC PH SENSITIVE DYES AND THEIR METHOD OF USE - A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula I: | 2016-05-19 |
20160139159 | DEVICES, SYSTEMS AND METHODS FOR EVALUATION OF HEMOSTASIS - Provided are devices, systems and methods for evaluation of hemostasis. Also provided are sound focusing assemblies. | 2016-05-19 |
20160139160 | CARDIOVASCULAR DISEASE RISK ASSESSMENT - The invention provides improved methods for analyzing cardiovascular disease risk. According to the invention, an algorithm that considers LDL and HDL subfractions, along with Lp(a) provides significant improvement in predicting CVD versus standard assays that include standard risk factors. Methods of the invention comprise measuring LDL and HDL subfractions in addition to Lp(a) without reference to standard risk factor measurements, such as CRP, total cholesterol, body mass index, weight, triglycerides, and the like. It is unexpected that an algorithm focusing only on LDL and HDL subfractions and Lp(a) would be more informative as to CVD risk than measurements that are much more comprehensive in terms of the markers that are reviewed. In particular, the sdLDL-C subfraction of LDL and the ApoA-1 in large alpha-1 HDL are most informative in conjunction with Lp(a). | 2016-05-19 |
20160139161 | SEROTONIN TRANSPORTER GENE AND TREATMENT OF ALCOHOLISM - The gene responsible for encoding SERT has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3′ UTR SNP rs1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on variations in the polymorphisms of the SERT gene as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders. | 2016-05-19 |
20160139162 | Inhibitors Of Fatty Acid Amide Hydrolase And Monoacylglycerol Lipase For Modulation Of Cannabinoid Receptors - Disclosed are compounds and compositions that inhibit the action of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL), methods of inhibiting FAAH and MGL, methods of modulating cannabinoid receptors, and methods of treating various disorders related to modulation of cannabinoid receptors. | 2016-05-19 |
20160139163 | Mobile Tip Waste Rack - A method of wasting tips in an automated processing module is disclosed, which includes at least three positions for holding sample racks. One of the positions is a tip waste rack position holding a tip waste rack, which includes tip receiving openings. Furthermore, it includes a SWAP rack holding mechanism for temporarily holding a sample rack. The method includes transferring the tip waste rack from the tip waste rack position to an adjacent sample rack position. Once the tip waste rack is placed in the adjacent sample rack position, the error pipette tip is discarded into one of the tip receiving openings of the tip waste rack. Following this, the tip waste rack is transferred back to the tip waste rack position. The sample rack temporarily placed in the SWAP rack holding mechanism is transferred from the SWAP rack holding mechanism to the adjacent sample rack position. | 2016-05-19 |
20160139164 | CARTRIDGE FOR DISPENSING A FLUID, AUTOMATIC ANALYZER AND METHOD OF ANALYZING A BIOLOGICAL SAMPLE - A cartridge for dispensing a fluid is presented. The cartridge comprises a reservoir chamber for receiving the fluid. The reservoir chamber has a fluid outlet. The cartridge further comprises a controllable dispenser component for dispensing a dispensing volume of the fluid from the reservoir chamber. The dispenser component is connected to the fluid outlet of the reservoir. The cartridge further comprises a single compressible fluid pump with a single elastic pumping element and a conduit extending from the fluid pump towards the fluid outlet. The fluid pump discharges a mixing volume of the fluid from the conduit into the reservoir chamber upon compression of the elastic pumping element. The mixing volume depends on the degree of compression of the elastic pumping element. The fluid pump sucks in the mixing volume from the reservoir into the conduit upon decompression of the elastic pumping element. | 2016-05-19 |
20160139165 | Method and Apparatus for a Controlled Delivery of Particles - In a method and in an apparatus for the controlled delivery of particles, said particles are supplied to a measurement station in which the quantity of particles is detected. The particles are subsequently transferred by the measurement station to a dispensing device and are dispensed. | 2016-05-19 |
20160139166 | Control unit for pipetting machines - A control unit for controlling a pipetting machine a pipetting machine, and a method for controlling a pipetting machine, wherein the control unit controls at least one actuator for moving a pipetting device between receptacle units for liquids to be pipetted and for receiving or dispensing liquids to be pipetted. The control unit, by selecting one or more graphic receptacle unit equivalents which correspond to receptacle units, assigns at least one transfer parameter to the receptacle unit equivalents. The transfer parameter corresponds to a transfer volume, which is to be received from the receptacle unit corresponding to the respective receptacle unit equivalent or is to be dispensed into the receptacle unit corresponding to the respective receptacle unit equivalent. The control unit is additionally designed so that selected source receptacle unit equivalents are simultaneously assignable to multiple target receptacle unit equivalents. | 2016-05-19 |
20160139167 | System including a sensor and an electrical cable - A system including a sensor and an electrical cable including electrical conductors, which are provided with an electrically insulating sheathing, the sensor being accommodated in a housing, the conductors of the cable are exposed from the sheathing at certain locations and the housing is fastened in an integrally bonded or form-fitting manner on the conductors of the cable at the exposed locations in the sheathing, and an electrically insulating sheathing is provided, which encloses the housing in a form-fitting manner and covers at least the cable in the area of the housing. | 2016-05-19 |
20160139168 | Fastening Device for an Electronic Component, in Particular an Acceleration Sensor for Airbag Systems - A fastening device for an electronic component, in particular an acceleration sensor for airbag systems, in which the electronic component is fixable in a motor vehicle with the aid of fastening elements, a first connection pair being present both on the motor vehicle and on the housing of the electronic component, which interlocks in a form-locked and/or force-fit manner for a pre-mounting of the electronic component and a second connection pair is present on the housing of the electronic component and on the motor vehicle, with the aid of which the electronic component may be fastened and positioned on the vehicle. The second connection pair is made up of a clip connection. | 2016-05-19 |
20160139169 | SEMICONDUCTOR DEVICE, PORTABLE TERMINAL DEVICE, AND OPERATION DETECTING METHOD - A semiconductor device in provided, the semiconductor device including an input unit to which an acceleration signal representing acceleration is input from an acceleration detecting unit installed in a portable terminal device, and a detection unit which detects that a tap operation is performed on the portable terminal device, in a case in which the acceleration signal input to the input unit reaches both of a first threshold value set on the positive side and a second threshold value set on the negative side and a period until the acceleration signal exceeds any one of the first threshold value and the second threshold value and then exceeds the other threshold value is equal to or more than a predetermined first period and is equal to or less than a second period larger than the first period. | 2016-05-19 |
20160139170 | ACCELEROMETER WITH STRAIN COMPENSATION - In some examples, a device comprises a proof mass and a support base configured to support the proof mass, wherein the proof mass is configured to displace in response to an acceleration of the device. The device also comprises a flexure configured to flexibly connect the proof mass to the support base. The device also comprises a strain-monitoring device configured to measure an amount of strain on the support base. | 2016-05-19 |