21st week of 2013 patent applcation highlights part 50 |
Patent application number | Title | Published |
20130130185 | METHOD FOR STARTING A SINTERING FURNACE, AND SINTERING EQUIPMENT - The invention relates to a method and equipment for starting up a strand sintering furnace ( | 2013-05-23 |
20130130186 | METHOD FOR THE CONTINUOUS SINTERING OF MINERAL MATERIAL AND SINTERING EQUIPMENT - The invention relates to a method and equipment for the continuous sintering of mineral material in a sintering furnace (S). In the method, a material bed ( | 2013-05-23 |
20130130187 | TEMPERATURE MEASUREMENT APPARATUS, METHOD OF ESTIMATING TEMPERATURE PROFILE, RECORDING MEDIUM AND HEAT TREATMENT APPARATUS - A temperature measurement apparatus for estimating a temperature profile in a process container, includes a radiation temperature measurement unit configured to measure the temperature of plural temperature measurement areas at a surface of the rotating table in a radius direction of the rotating table by scanning the surface of the rotating table in the radius direction; an operation control unit that controls to start heating of the process container by a heater while keeping the rotating table immobilized, and controls to repeat a scanning operation, in which the radiation temperature measurement unit scans the surface of the rotating table in the radius direction to obtain the temperature of the plural temperature measurement areas while the rotating table is rotated in a circumferential direction of the rotating table, after a predetermined period has passed from starting the heating of the process container. | 2013-05-23 |
20130130188 | GRID PLATE - The present invention relates to a grid plate for the transporting and cooling of very hot materials leaving a It furnace, said plate having cavities of rectangular shape, the largest dimension being perpendicular to the direction of advance of the materials, the cross section of these cavities being triangular with a fin-shaped bottom terminating in a turned-up end of reverse slope, the slope (α) of the cavities being between 10° and 45°, preferably between 20° and 30°, to the horizontal and the reverse slope (β) of the turned-up end making an angle equal to or up to 6° less than the angle of the slope of the cavities. The flow of material under gravity through the air injection slits is interrupted. Any contact of the material with the framework and with the mechanism of the equipment is avoided. | 2013-05-23 |
20130130189 | ORTHODONTIC BRACKET - An orthodontic bracket which can be selectively active or passive, and can be active or passive on one tooth and can be independently active or passive on adjacent or any other tooth. The bracket includes a body having a groove for receiving an archwire, a slide for moving from an open position to a closed position to thereby capture the archwire, and a spring slidably engageable in the slide in either a passive or an active position. When in the active position the spring bears on the archwire. A method of using this orthodontic bracket comprises mounting the body to a patient's tooth with the slide in the open position, inserting an archwire into the groove in the body and closing the slide to secure the archwire in the groove. The spring can be in the passive or in the active position. | 2013-05-23 |
20130130190 | Orthodontic Force Module Including Elastomeric Member for Class II and Class III Correction - Orthodontic force modules for use in correcting class II and/or class III malocclusions. In one embodiment, the force module ( | 2013-05-23 |
20130130191 | OPTICAL TOMOGRAPHY IMAGE ACQUISITION DEVICE - The optical tomography image acquisition device comprises a tomographic image computer ( | 2013-05-23 |
20130130192 | LUMINESCENT IMPRESSION MATERIAL - A physiologically compatible impression material comprises 0.005 wt % to 4.99 wt %, preferably 0.01 wt % to 1.0 wt %, and particularly preferably 0.025 wt % to 0.25 wt % of at least one luminescent material. | 2013-05-23 |
20130130193 | ORAL ORTHOSIS HANDLE - A handle for removably attaching to a moldable orthosis positions the orthosis in boiling water. The handle includes an arm with an oral orthosis engaging member at one end. The engaging member includes one of a tab or slot which removably engages the oral orthosis. In a preferred embodiment, the arm further includes a hook-like member for supporting the oral orthosis on the rim of a container of boiling water during the molding process. In one embodiment, the handle forms the cover of a storage case for the orthosis. | 2013-05-23 |
20130130194 | NON-CUSTOM DENTAL TREATMENT TRAYS HAVING IMPROVED ANATOMICAL FEATURES - A non-custom, dental tray device includes a moisture-resistant barrier layer having a labial-buccal wall, a lingual wall, and a bottom wall. The dental tray device includes at least one of the following structural features to enhance the fit of the device; (1) the bottom wall includes an abrupt reduction of width at a location corresponding to where the first bicuspid meets the canine; (2) a bottom wall in the posterior region having a width that is equal to or less than the width of the bottom wall in the anterior region, with no lingual wall in the posterior region; or (3) a transition portion between the bottom wall and either the labial-buccal wall or the lingual wall has a larger radius of curvature as compared to a radius of curvature at a transition portion between the bottom wall the other of the labial-buccal wall and the lingual wall. | 2013-05-23 |
20130130195 | MANDIBLE POSITION INDICATOR FOR MEASURING AND REPLICATING OCCLUSION - One embodiments of the present subject matter include a method that includes fixing a top pantograph to a patient via clutches to the top teeth of the patient, fixing a bottom pantograph to a patient via clutches to the bottom teeth of the patient, optically monitoring the bite of the patient by monitoring the relation of the top pantograph to the bottom pantograph during a bite cycle, storing data relating to the actual bite storing patient data including a three-dimensional model including a top teeth model and a bottom teeth model, storing a digital top pantograph model associated with the top pantograph, storing a digital bottom pantograph model associated with the bottom pantograph, digitally pairing the bite data, the top pantograph model and the bottom pantograph model to the patient data, and digitally modeling the bite. | 2013-05-23 |
20130130196 | DRUG-CONTAINING PERSONAL HYGIENE IMPLEMENT - To provide an economical and sanitary drug-containing personal hygiene implement that is easy to produce and manage, and has an excellent portability even when both personal hygiene implement and drug are used away from home. | 2013-05-23 |
20130130197 | SYRINGE-TO-SYRINGE MIXING SYSTEMS AND RELATED APPARATUS AND METHODS - A hollow syringe barrel for use in syringe mixing systems for mixing a two-component composition. A hollow body of the syringe barrel includes a proximal end, a distal end, and continuous cylindrical wall defining an internal chamber for containing a first component. A rupturable membrane disposed at the distal end caps and seals off a single dispensing orifice. A second syringe barrel can be coupled to the distal end of the hollow syringe barrel to form a syringe-to-syringe mixing system. First and second plungers disposed within the hollow syringe barrel and second syringe barrel, respectively, are used to mix and cycle back and forth first and second components initially contained within the hollow syringe barrel and second syringe barrel. The two components are initially separated by the rupturable membrane, which is irreversibly ruptured by applying sufficient pressure to the first plunger within the hollow syringe barrel prior to mixing. | 2013-05-23 |
20130130198 | PROPHY ANGLE - The present invention provides a dental prophylaxis angle that includes a housing, a rotor disposed in the housing, and a drive shaft driving the rotor. The drive shaft and the rotor operate together with a sidewall of the housing against a common surface of the rotor to prevent removal of the rotor from the housing in a direction along an axis of rotation of the rotor. | 2013-05-23 |
20130130199 | Apparatus and Method for Dental Seating - An apparatus and method for a consistent and efficient way to seat dental prosthetics in any area of a patient's mouth is disclosed. The present invention comprises an apparatus and method to allow for easy and efficient seating of Dental Prosthetics by use of an inventive dental seater apparatus (“Dental Seater”). The present invention addresses all of the above mentioned deficiencies of the conventional methods. In particular, the present invention increases the predictability and utility of seating results by having the Dental Seater fabricated using preferred firm materials, including without limitation any of the currently used dental materials. In addition, the present invention can be used in any part of the mouth, and in either arch (maxilla or mandible), and with any currently used Dental Prosthetics. | 2013-05-23 |
20130130200 | Flatbed Dental Implant - A flatbed dental implant that includes an open-topped cylindrical body having an ovoid elongate planar portion centrally disposed thereabouts, said planar portion disposed perpendicularly relative the cylindrical body proximal to the open end of said body, and a frustoconical member disposed basally upon the cylindrical body, said frustoconical member having a lip disposed circumferentially about the body, which lip tapers to a cylindrical ring tip enclosing the cylindrical body at a bottom end, wherein the planar portion is osteally engaged when mounted within a shallow subcortical bed incised beneath a mucoperiosteal flap of a jawbone, whereby the flatbed dental implant is securely implanted to support an extant denture therein without risking injury to the inferior aveolar nerve, maxillary sinus, or other endosteal tissue and proximal anatomy as may otherwise occur when incising to a greater depth. | 2013-05-23 |
20130130201 | Process For Fabrication of a Dental Implant Restoration System - A process for the manufacture of a dental implant restoration system including an abutment for attaching a dental prosthesis within a patient's mouth. The abutment is a single unit structure fabricated of a ceramic material, multicolored throughout to match the color of the dental prosthesis, the surrounding dentition and the surrounding gingival tissue. | 2013-05-23 |
20130130202 | METHOD FOR DENTAL RESTORATION AND RELATED KIT - The disclosure generally relates to a method for forming a dental mold. The method generally includes: (a) scanning an existing dental structure to generate a three-dimensional first digital model of the existing dental structure, (b) modifying the first digital model of the existing dental structure to generate a three-dimensional second digital model of a planned dental structure; (c) generating a three-dimensional third digital model corresponding to a negative of the second digital model; (d) digitally sectioning the third digital model into at least one buccal model portion and at least one lingual model portion of the third digital model; and (e) creating a dental mold comprising at least one buccal mold portion and at least one lingual mold portion based on the sectioned third digital model. The disclosure also relates to (a) methods of assembling the dental mold over a tooth and a gum of a patient having an existing dental structure in need of dental restoration, (b) methods of performing a dental restoration on the existing dental structure of the patient using the dental mold, and (c) kits including components for forming the dental mold and/or for performing the dental restoration using the dental mold. | 2013-05-23 |
20130130203 | POLYMER COATED DENTAL ARTICLES AND METHOD OF MAKING THE SAME - Provided are methods of improving the wear resistance and aesthetic properties of dental articles, as well as dental articles having an abrasion resistant polymeric coating thereon. | 2013-05-23 |
20130130204 | FIREARM SIMULATION SYSTEM SIMULATING LEADING FIRE, LASER-EMITTING DEVICE, AND TARGET DETECTION DEVICE - Provided is a firing weapon simulation system simulating leading firing. The firing weapon simulation system is configured to include laser firing apparatus mounted on a firing weapon and a target sensing apparatus attached to a target. The laser firing apparatus includes a first control unit, a firing switch which is driven cooperatively with firing of the firing weapon, an image processing unit which measuring a leading angle from an image including the moving target, a first GPS receiver, a laser beam firer, and a motor assembly which rotates the laser beam firer. When the firing switch is switched on, the first control unit generates the firing data, allows the motor assembly to reversely rotate the laser beam firer by a measured value of the leading angle, and allows the laser beam firer to emit the laser beam carrying the firing data. The target sensing apparatus includes a second control unit, a sensing circuit unit which extracts firing data from the laser beam, a second GPS receiver, and a hitting situation indicator which indicates hitting result according to a driving signal transmitted from the second control unit. The second control unit solves simultaneous equations of the trajectory equation of the firing weapon and the equation of motion of the target to determine whether or not the target is hit and outputs a result of the determination to the hitting situation indicator. | 2013-05-23 |
20130130205 | DYNAMIC TARGETING AND TRAINING SYSTEM - A live-fire simulation system uses a position sensitive detector (PSD) in a weapon-mounted sensor to intercept emitted light from target emitters spatially distributed about a target. Each target emitter is modulated with a unique frequency. The system can thus not only determine the points of interception on the PSD but also determine which emitter caused which interception by using a frequency analysis. | 2013-05-23 |
20130130206 | Rowing Simulator and Training Aid - An apparatus that enables one or more people to simulate on land the action of rowing on water, including the simulation of an oar blade entering into and being extracted from water that is moving relative to a boat, and including feedback on rowing performance and technique. The apparatus includes the same fundamental elements as a real rowing boat, with one or two oar handles | 2013-05-23 |
20130130207 | OBSERVATION PLATFORM FOR TRAINING, MONITORING AND MINING STRUCTURED COMMUNICATIONS - Using an observation platform for training, monitoring, and mining structured communications. A signal is received from a first communication device at a second communication device associated with a computer system, wherein a first characteristic of the signal corresponds to an audible source and a second characteristic of the signal corresponds to information indicative of a geographic position of the first communication device. | 2013-05-23 |
20130130208 | SYSTEMS AND METHODS FOR ORDERING PREPARED FOOD PRODUCTS - Systems and methods are provided for ordering prepared food products via a network using an electronic device. A menu of available prepared food products may be presented on a display, and one of the prepared food products may be selected using an interface of the device. A menu of bread items available may be presented including visual representations of each available bread item. One of the bread items may be selected, whereupon a visual representation of the selected bread may be presented. One or more ingredients may be selected using the interface, whereupon visual representations of the ingredients are superimposed on the visual representation of the selected bread item. The systems and methods may provide an enhanced visual experience similar to ordering the product in person and watching the product being made. | 2013-05-23 |
20130130209 | METHODS AND APPARATUS FOR FOREIGN LANGUAGE INSTRUCTION VIA A TOUCH INTERFACE - Methods and apparatus for foreign language instruction. In one exemplary aspect, a “cascading” user interface is used for foreign language instruction in limited form factor devices. The cascading user interface is based on a “multiple choice” type selection, where each selection is further “modified” in subsequent selections. By cascading multiple steps for each translation step, the device can represent a significantly larger set than would otherwise be possible, given the limitations of the user interface. Proper (and improper) selection may be indicated e.g., via a chime, animation, etc. | 2013-05-23 |
20130130210 | LANGUAGE TEACHING SYSTEM THAT FACILITATES MENTOR INVOLVEMENT - Disclosed herein, in certain embodiments, are computer-based language immersion teaching systems, products, programs, and methods comprising a digital processing device and a computer program that creates a language immersion teaching environment, wherein said environment comprises: a plurality of learning activities associated with a target language; a software module for providing voiceover audio in said target language; and a software module for providing translation of said voiceover and/or text from said target language to a specified language, wherein said translation is both written and voiced, and wherein said software module for providing translation of voiceover and/or text is adapted for use by a mentor to a learner of said target language. | 2013-05-23 |
20130130211 | COMPUTER-BASED LANGUAGE IMMERSION TEACHING FOR YOUNG LEARNERS - Disclosed herein, in certain embodiments, are computer-based language immersion teaching systems, products, programs, and methods for learners aged about 3 to about 10 years comprising a digital processing device and a computer program that creates a language immersion teaching environment, wherein said environment comprises a plurality of learning activities associated with a target language, and wherein said plurality of activities comprises: at least one learning activity based on a taxonomy of phonemes; at least one learning activity selected from: songs, chants, books, poems, puzzles, games, art activities, and printable activities; voiceover audio in said target language; and a software module for recording said learner's pronunciation and comparing it to one or more model pronunciations. | 2013-05-23 |
20130130212 | LANGUAGE PHONEME PRACTICE ENGINE - Disclosed herein, in certain embodiments, are computer-based language phoneme practice systems, products, programs, and methods comprising a digital processing device and a computer program that creates a language phoneme practice engine, wherein said engine comprises: a taxonomy of phonemes of a target language; a software module for providing an interface for practicing each said phoneme in said taxonomy, wherein said interface allows a learner to optionally access a visual representation and an auditory representation of each said phoneme in said taxonomy; and a software module for providing an interface for practicing each said phoneme in the context of the beginning, middle, and end of words of said target language, wherein said interface allows a learner to optionally access a visual and an auditory representation of each said word and each said phoneme in each said word. | 2013-05-23 |
20130130213 | ACTIVITY MONITOR AND ANALYZER WITH VOICE DIRECTION FOR EXERCISE - A system is disclosed for monitoring and analyzing activity of a subject. The system includes a condition setting unit for setting a schedule for the subject in association with a clock, a voice recording and play-back unit for recording a set of personalized messages for the subject, and a motion detection unit for monitoring, in association with the clock, whether an expected activity has occurred. The voice recording and play-back unit plays one of the set of personalized messages responsive to whether the expected activity has occurred. | 2013-05-23 |
20130130214 | BEHAVIOR CHARACTERISTIC EXTRACTION DEVICE, A BEHAVIOR CHARACTERISTIC EXTRACTION SYSTEM, A BEHAVIOR CHARACTERISTIC EXTRACTION METHOD AND A BEHAVIOR CHARACTERISTIC EXTRACTION PROGRAM - A behavior pattern storing unit stores stay point information for a plurality of stay points including a stay point of a first behavior base type corresponding to a first behavior type and a stay point of a second behavior base type corresponding to a second behavior type, a behavior characteristic extraction unit extracts days on which a stay at a stay point of the first behavior base type was performed as a day regarding the first behavior type by referring the stay point information, calculates, if a stay at an other stay point different from the stay points of the first and the second behavior base type was performed on days regarding the first behavior type, a stay frequency at the stay point of the first behavior base type during the same time zone as the stay at the other stay point, for the days regarding the first behavior type. | 2013-05-23 |
20130130215 | System and Method Considering the Effect of Physical Activity on the Glucoregulatory System - A system and method for considering the effects of aerobic exercise on blood glucose levels for individuals is described. In at least one embodiment of the system of the present disclosure, the system comprises a computing device for generating a prediction of future blood glucose levels for the individual at least partly based on an exercise model, wherein the exercise model is based on parameters that are independent of intensity of the aerobic exercise, and a means for taking an action at least based on the prediction from the exercise model. | 2013-05-23 |
20130130216 | CUSTOM NARRATION OF ELECTRONIC BOOKS - A system and method are disclosed for correlating an electronic book with a narration. A correlation is determined between a first portion of the narration and a first segment of the text within the electronic book. The correlation is stored as instructions to present the first segment of the text with emphasis simultaneously with playback of the first the portion of the narration. A determination is made that a second portion of the audio recording, immediately following the first portion, does not match a second segment of the text that immediately follows the first segment. A correlation between the second portion and a component of the electronic book is determined and stored as instructions to present the component with emphasis simultaneously with playback of the second portion of the narration. | 2013-05-23 |
20130130217 | E-LEARNING LESSON DELIVERY PLATFORM - Disclosed herein are e-learning lesson delivery platforms, products, programs, and methods comprising a digital processing device and a program that creates a lesson delivery server, wherein said server comprises: a plurality of learning activities, wherein said activities are organized according to an instructional plan designed to accomplish one or more educational objectives in at least one subject, wherein said plan identifies one or more activities for use in a guided environment and one or more activities for assignment as independent work; a module for displaying and providing access to said one or more activities in a guided environment; a module for assigning said one or more activities as independent work to one or more learners, wherein said module is only accessible by a mentor; and a module for displaying and providing access to activities assigned as independent work, wherein said module is accessible by a mentor or a learner. | 2013-05-23 |
20130130218 | Application for Remote Administration and Scoring of NIHSS on Mobile Devices - Systems and methods for remotely administering and scoring a scored diagnostic test on a mobile device including a graphical display. In accordance with the methods, a scoring component of the scored diagnostic test is provided to the graphical display of the mobile device. The scoring component instructs a remote healthcare professional to measure and document different aspects of the scored diagnostic test. Further, a video component of the scored diagnostic test is provided on the graphical display of the mobile device. The video component allows the remote healthcare professional to view a patient while remotely administering the scored diagnostic test. | 2013-05-23 |
20130130219 | SYSTEMS AND METHODS FOR PROVIDING A DYNAMIC CONTINUAL IMPROVEMENT EDUCATIONAL ENVIRONMENT - Dynamic systems and methods for gathering/tracking data, automatically adapting to an individual's pace of learning, selectively determining the type of content provided to an individual, selectively providing an exposure frequency for the content, and/or enabling rapid design modifications within the educational environment. Educational content is dynamically designed and customizably presented to an individual learner. An analysis is performed on the data to optimize learning. Modifications are selectively or automatically made to the educational content. The process of designing, implementing, analyzing, and selectively modifying creates a cycle that optimizes the learning process and adapts to individual learners. Furthermore, the educational content is dynamically provided to the learner on an iterative basis according to the need of that learner in the learning process. | 2013-05-23 |
20130130220 | PRINTED ARTICLE COMPRISING AN ELECTRONIC DEVICE - An article ( | 2013-05-23 |
20130130221 | System and Method to Facilitate Creation of Educational Information - The computer-implemented system to facilitate creation of educational information employs a networked computer system that stores at least one resource in association with a first electronic file, storing metadata information about usage of the resource. A resource assembly tool implemented by a computer is programmed to access the networked computer system to display information to an instructor about at least one resource, including the metadata information. This aids the instructor in selecting resources for inclusion in educational information being created. The resource assembly tool is configured to assemble the educational information to include resources selected for inclusion being created for dissemination to learners via said networked computer system. The networked computer system is further configured to capture information about usage of the resource and to update the stored metadata information to reflect said captured information. | 2013-05-23 |
20130130222 | DEVICE, KIT AND METHOD FOR USE IN OPHTHALMOLOGY - The present invention refers to a device and a kit for the shipment and the preservation of corneal lenticules ready for use in a lamellar keratoplasty surgery. The present invention also refers to a method for preserving, shipping and prearranging the lenticules so as to facilitate posterior lamellar keratoplasty surgery (or endokeratoplasty). | 2013-05-23 |
20130130223 | NOVEL CONDITIONALLY IMMORTALIZED HUMAN PROXIMAL TUBULE CELL LINE EXPRESSING FUNCTIONAL INFLUX AND EFFLUX TRANSPORTERS - The invention relates to the field of biology and medicine. In particular, the invention relates to the field of pharmaceutical research and drug development, and especially to means for physiological, pharmacological and toxicological research. More in particular, the invention provides renal cell lines with proximal tubular characteristics including multiple influx and efflux transporters. These cell lines are termed ciPTEC. Four representative examples have been deposited at the Deutsche Sammlung von Mikroorganismen and Zellkulturen GmbH (DSMZ or German Collection of Microorganisms and Cell Cultures) at Inhoffenstrasse 7 B, 38124 Braun-schweig, Germany under accession number DSM ACC3019, DSM AC-C3020, DSM ACC3021 and DSM ACC3022. | 2013-05-23 |
20130130224 | Method For The Analysis of Biological Samples Through Medical Ultrasound - A method for the conservation of human and animal anatomical parts, both normal and pathological, which comprises a hydration phase, immersion phase and packing phase. The hydration phase comprises immersing the anatomical part in and preserving and hydrating substance. The Immersion and Packing phases comprise immersing the specimen in a gel substance contained in a polyurethane, gel latex or silicone container that allows its analysis and study by ultrasound. | 2013-05-23 |
20130130225 | COMPOSITION FOR THE COLD STORAGE OF ORGANS - The present invention relates to a cold organ preservation composition for transplantation comprising a cold organ preservation solution and cardiotrophin-1 or a functionally equivalent variant thereof. The invention also relates to methods and kits for the preparation of said composition, the uses thereof for the cold organ protection and/or preservation for transplantation (particularly for kidney, lung and heart) and also to the cold preservation methods and cold-preserved isolated organs by these methods. | 2013-05-23 |
20130130226 | Microfluidics Sorter For Cell Detection And Isolation - A method of detecting one or more diseased blood cells in a blood sample includes introducing a blood sample into at least one inlet of a microfluidic device comprising one or more linear channels wherein each channel has a length and a cross-section of a height and a width defining an aspect ratio adapted to isolate diseased blood cells along at least one portion of the cross-section of the channel based on reduced deformability of diseased blood cells as compared to non-diseased blood cells, wherein diseased blood cells flow along a first portion of the channel to a first outlet and non-diseased blood cells flow along a second portion of the channel to a second outlet. The one or more channels can be adapted to isolate cells along portions of the cross-section of the channel based on cell size. In some embodiments, the one or more channels can be spiral channels. | 2013-05-23 |
20130130227 | Infectious Disease Detection System - A method and apparatus for managing a zone. Information is obtained about an environment in the zone with a sensor system. A determination is made by an analyzer system as to whether a contagious condition is present in the zone using the information from the sensor system. An action is performed by a management system in response to the contagious condition being present. | 2013-05-23 |
20130130228 | METHOD AND DEVICE FOR IDENTIFYING MULTIPOTENT STEM CELL COLONY, AND METHOD AND DEVICE FOR AUTOMATICALLY CULTURING MULTIPOTENT STEM CELLS - A method and device achieves identification on whether a colony on a cultivation container is differentiated or undifferentiated on an occasion of cultivation of multipotent stem cell, and a method and device achieves a rapid culture of undifferentiated multipotent stem cells. Undifferentiated colony containing only undifferentiated multipotent stem cells is identified from other types of colonies by means of the circularity C of the colony in an image-processed taken image of the inside of cultivation container of a multipotent stem cell. More specifically, when a first threshold of the circularity of the colony is C | 2013-05-23 |
20130130229 | Method for Detecting Nucleic Acid Amplification in Sample and Device Therefor - A device for detecting nucleic acid amplification in a sample, comprising: a loading unit (thermoregulation unit) which is provided with a plurality of holes for loading reaction containers and capable of arbitrarily controlling a measurement unit for measuring samples in the containers that are loaded in the holes. The loading unit and the measurement unit, which are placed opposite to each other, can be operated independently from each other. In a transfer operation, the operation speeds of the thermoregulation unit and measurement unit are controlled so that the sum of these speeds amounts to an arbitrary constant value. | 2013-05-23 |
20130130230 | PROTEIN-ENCLOSED CARBON NANOTUBE FILM, AND SENSOR AND POWER-GENERATING DEVICE EACH EQUIPPED WITH THE CARBON NANOTUBE FILM AS ELECTRODE - The present invention answers the demands of power generating device and biosensor development and provides a flexible, free-standing type protein containing carbon nanotube film, and a sensor and power generating device each equipped with the carbon nanotube film as an electrode. According to the present invention a carbon nanotube free standing film is provided including a carbon nanotube aggregate formed by aggregating a plurality of carbon nanotubes, and a plurality of enzymes included between the plurality of carbon nanotubes. The carbon nanotube film may include a different protein to the enzyme and may include a surfactant agent between the plurality of carbon nanotubes. | 2013-05-23 |
20130130231 | Bioinformatically detectable group of novel viral regulatory genes and uses thereof - The present invention relates to a group of novel viral RNA regulatory genes, here identified as “viral genomic address messenger genes” or “VGAM genes”, and as “genomic address genes” or “GR” genes. VGAM genes selectively inhibit translation of known host target genes, and are believed to represent a novel pervasive viral attack mechanism. GR genes encode an operon-like cluster of VGAM genes. VGAM and viral GR genes may therefore be useful in diagnosing, preventing and treating viral disease. Several nucleic acid molecules are provided respectively encoding several VGAM genes, as are vectors and probes both comprising the nucleic acid molecules, and methods and systems for detecting VGAM genes, and for counteracting their activity. | 2013-05-23 |
20130130232 | SELF-LOADING MICROFLUIDIC DEVICE AND METHODS OF USE - Microfluidic devices and methods for conducting chemical assays and biological assays using microfluidic devices are disclosed. The microfluidic devices do not require external connections, tethers, tubing, valves and actuators. The microfluidic devices are useful in methods for analyzing a wide variety of chemical and biological assays such as, for example, molecule-molecule interactions, enzyme-substrate interactions, molecule identification, minimum inhibitory concentrations, therapeutically effective amounts, and toxic amounts. | 2013-05-23 |
20130130233 | MONOCLONAL ANTIBODIES TO HUMAN IMMUNODEFICIENCY VIRUS AND USES THEREOF - The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample. | 2013-05-23 |
20130130234 | POST PROTEIN HYDROLYSIS REMOVAL OF A POTENT RIBONUCLEASE INHIBITOR AND THE ENZYMATIC CAPTURE OF DNA - The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate confining the pathogens and introducing a fibrin lysis reagent to expose the pathogens for analysis. The present invention also concerns materials and methods for removing aurintricarboxylic acid (ATA) from a sample. | 2013-05-23 |
20130130235 | PROBES AND PRIMERS FOR DETECTION OF DENGUE - The present disclosure gives description of a method used for the detection and quantification of dengue viral infection caused by dengue virus using nucleic acids isolated from blood, plasma or serum samples by employing Oligonucleotide probes. The method employed here for detection is by Real time PCR. The instant disclosure also provides for primers, probes, PCR Reaction mixture and kit thereof. | 2013-05-23 |
20130130236 | SEPARATION METHOD OF LABELED CELLS AND USES THEREOF - A method for separating labeled cells and a use (of the labeled cells) thereof are provided. More specifically, a method for labeling cells using fluorescent magnetic nanodiamonds, and a method for separating the labeled cells using the labeling method by the fluorescent or magnetic properties of the nanodiamonds are provided. | 2013-05-23 |
20130130237 | APPARATUS AND METHOD FOR ANALYZING STATE OF DNA - The present invention provides an analysis apparatus including: an irradiation section for irradiating the chromatin structure with terahertz waves; a detection section for acquiring a set of terahertz wave spectral information from the chromatin structure; a memory section for memorizing the sets of terahertz wave spectral information corresponding to the states of the chromatin structure; and a data processing section for analyzing the state of the chromatin structure by comparing the set of spectral information acquired in the detection section and the sets of spectral information memorized in the memory section. | 2013-05-23 |
20130130238 | Fluorimetric Process for Evaluating the Influence of A Condition on A Biological Sample and Applications Thereof - The present invention relates to a process for determining the influence of a condition on a biological sample comprising a step consisting in establishing the kinetic profile of the fluorescence emitted, during the excitation at a suitable excitation wavelength, of a fluorescent compound bound to said biological sample, said sample having been, prior to said excitation, subjected to said condition and said process not necessitating the utilization of a fluorescence donor component and of a different fluorescence acceptor component. The present invention also relates to the various applications of such a process. | 2013-05-23 |
20130130239 | Test for Detecting Xanthomonas axonopodis pv. allii - The present invention relates to novel tools for detecting | 2013-05-23 |
20130130240 | METHODS FOR IDENTIFYING DRUG RESISTANT MYCOBACTERIUM - Presented herein are methods for determining the presence of a non-mutated | 2013-05-23 |
20130130241 | ANDROGEN RECEPTOR ISOFORMS AND METHODS - The invention relates to exploiting differences in androgen receptor gene amplification and expression of androgen receptor isoforms in various cell types such as, for example, prostate tumor cells. In one aspect, the invention provides a method for detecting unbalanced amplification of androgen receptor isoforms. Generally, the method includes receiving a biological sample obtained from a subject, the biological sample comprising cells expressing a plurality of non-wild-type androgen receptors, measuring the copy number of at least a polynucleotide encoding a first non-wild-type androgen receptor and a polynucleotide encoding a second non-wild-type androgen receptor, thereby producing an expression ratio, and identifying the sample as exhibiting unbalanced amplification of androgen receptor if the expression ratio is no less than a predetermined expression ratio. In another aspect, the invention provides a method of analyzing a biological sample from a subject. Generally, the method includes receiving the biological sample, the biological sample comprising cells expressing a plurality of androgen receptor isoforms, measuring expression of at least one androgen receptor isoform, and identifying the sample as exhibiting a predetermined pattern of androgen receptor isoform expression if at least one predetermined pattern of androgen receptor expression is detected. | 2013-05-23 |
20130130242 | METHOD FOR DETERMINING PRESENCE OR ABSENCE OF CANCER CELL IN BIOLOGICAL SAMPLE, AND MOLECULAR MARKER AND KIT FOR DETERMINATION - The present invention relates to a method for determining presence or absence of a cancer cell in a biological sample based on the analysis result obtained by analyzing methylation status of DNA extracted from the biological sample with a novel molecular marker allowing a determination of presence or absence of the cancer cell. | 2013-05-23 |
20130130243 | METHOD AND DEVICE FOR DETECTING AND QUANTIFYING AN ANALYTE WITH RECYCLING OF THE REAGENTS - The present invention relates to a method for detecting and quantifying an analyte present in a liquid of interest using a solid support, the surface of which comprises at least one active area on which at least one probe capable of binding said analyte is immobilized and a solution containing at least one secondary reagent capable of binding to the analyte, said method comprising a step consisting of recycling said solution in order to put it back into contact with the surface and notably with the active area at least one additional time. The present invention also relates to a device which may be applied within the scope of such a method. | 2013-05-23 |
20130130244 | P53 ASSAY FOR A URINE TEST FOR HCC SCREENING - A rapid and sensitive assay to detect p53 mutations in urine has been developed for use in screening cancer patients. The method uses a locked nucleic acid (LNA) clamp mediated one-step PCR-based assay with a sensitivity of up to a single copy and can be used not only in urine, but also other biological samples. The assay is particularly useful for hepatocellular carcinoma, colon cancer, breast cancer, lung cancer, prostate cancer, ovarian cancer, bladder cancer, lymphoma, and stomach cancer. | 2013-05-23 |
20130130245 | METHOD OF PLANT GENOME DESIGN, METHOD OF CREATING NEW CULTIVAR AND NEW CULTIVAR - Plant genome design method defines DNA markers M1 to M5, for each target region, DNA marker M2 is at an upstream side of a target region, or upstream thereof, DNA marker M1 is upstream of DNA marker M2, DNA marker M4 is at a downstream side of the target region, or downstream thereof, DNA marker M5 is downstream of DNA marker M4, and DNA marker M3 is in the target region; and designs a genome so that a substitution region, containing the target region, in a chromosome of the original cultivar to be substituted with a chromosome fragment derived from the foreign cultivar has an end on an upstream side between DNA marker M1 and DNA marker M2, and an end on a downstream side of the substitution region between DNA marker M4 and DNA marker M5. | 2013-05-23 |
20130130246 | METHODS FOR THE DETECTION, VISUALIZATION AND HIGH RESOLUTION PHYSICAL MAPPING OF GENOMIC REARRANGEMENTS IN BREAST AND OVARIAN CANCER GENES AND LOCI BRCA1 AND BRCA2 USING GENOMIC MORSE CODE IN CONJUNCTION WITH MOLECULAR COMBING - Methods for detecting genomic rearrangements in BRCA1 and BRCA2 genes at high resolution using Molecular Combing and for determining a predisposition to a disease or disorder associated with these rearrangements including predisposition to ovarian cancer or breast cancer. Primers useful for producing probes for this method and kits for practicing the methods. | 2013-05-23 |
20130130247 | Kits and Methods for Assessing Skin Health - The invention relates to kits and methods for assessing skin health for a human and the human's susceptibility to skin disorders. The methods involve assessing occurrence in the human's genome of one or more polymorphisms (e.g., single nucleotide polymorphisms) that occur in one or more genes associated disclosed herein and that are associated with a disorder in humans. Preferred assessment and scoring methods are disclosed, as are kits for performing the methods. | 2013-05-23 |
20130130248 | ENDORIBONUCLEASE COMPOSITIONS AND METHODS OF USE THEREOF - The present disclosure provides variant Csy4 endoribonucleases, nucleic acids encoding the variant Csy4 endoribonucleases, and host cells genetically modified with the nucleic acids. The variant Csy4 endoribonucleases find use in a variety of applications, which are also provided. The present disclosure also provides methods of detecting a specific sequence in a target polyribonucleotide; and methods of regulating production of a target RNA in a eukaryotic cell. | 2013-05-23 |
20130130249 | NUCLEIC ACID PRODUCTION AND SEQUENCE ANALYSIS - A method for producing a nucleic acid molecule from a template nucleic acid sequence and a linking unit attached to a primer, which method comprises a step of contacting the template nucleic acid sequence with a nucleic acid polymerase under conditions which allow the nucleic acid polymerase to produce the nucleic acid molecule from the primer based on the template nucleic acid sequence, wherein the linking unit is attached to a target site in the template nucleic acid sequence with a covalent linkage. | 2013-05-23 |
20130130250 | ISOLATED GLUCOKINASE GENOMIC POLYNUCLEOTIDE FRAGMENTS FROM CHROMOSOME 7 - Provided are isolated genomic polynucleotide fragments that encode human SNARE YKT6, human glucokinase, human adipocyte enhancer binding protein (AEBP1) and DNA directed 50 kD regulatory subunit (POLD2), vectors and hosts containing these fragments and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using these fragments to obtain SNARE YKT6, human glucokinase, AEBP1 protein and POLD2 and to diagnose, treat, prevent and/or ameliorate a pathological disorder. | 2013-05-23 |
20130130251 | IDENTIFICATION OF SNARE YKT6 SEQUENCES - Provided are isolated genomic polynucleotide fragments that encode human SNARE YKT6, human glucokinase, human adipocyte enhancer binding protein (AEBP1) and DNA directed 50 kD regulatory subunit (POLD2), vectors and hosts containing these fragments and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using these fragments to obtain SNARE YKT6, human glucokinase, AEBP1 protein and POLD2 and to diagnose, treat, prevent and/or ameliorate a pathological disorder. | 2013-05-23 |
20130130252 | IDENTIFICATION OF POLD2 SEQUENCES - Provided are isolated genomic polynucleotide fragments that encode human SNARE YKT6, human glucokinase, human adipocyte enhancer binding protein (AEBP1) and DNA directed 50kD regulatory subunit (POLD2), vectors and hosts containing these fragments and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using these fragments to obtain SNARE YKT6, human glucokinase, AEBP1 protein and POLD2 and to diagnose, treat, prevent and/or ameliorate a pathological disorder. | 2013-05-23 |
20130130253 | METRONIDAZOLE RESISTANCE IN TRICHOMONAS VAGINALIS AND SINGLE NUCLEOTIDE POLYMORPHISMS - The present invention is directed to the discovery of single nucleotide polymorphisms (SNPs) in the presence of metronidazole-resistant | 2013-05-23 |
20130130254 | OPTICAL RESONATOR DIAGNOSTIC DEVICE AND METHODS OF USE - An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times. | 2013-05-23 |
20130130255 | OPTICAL MAPPING OF GENOMIC DNA - A method for single-molecule optical DNA profiling using an exceptionally dense, yet sequence-specific coverage of DNA with a fluorescent probe, using a DNA methyltransferase enzyme to direct the DNA labeling, followed by molecular combing of the DNA onto a polymer-coated surface and subsequent sub-diffraction limit localization of the fluorophores. The result is a ‘DNA fluorocode’; a simple description of the DNA sequence, with a maximum achievable resolution of less than 20 bases, which can be read and analyzed like a barcode. The method generates a fluorocode for genomic DNA from the lambda bacteriophage using a DNA methyltransferase to direct fluorescent labels to four-base sequences reading 5′-GCGC-3′. A consensus fluorocode is constructed that allows the study of the DNA sequence at the level of an individual labeling site and is generated from a handful of molecules and entirely independently of any reference sequence. | 2013-05-23 |
20130130256 | ACF DETECTION METHOD - The present invention provides a method for detecting ACF by analyzing a test region of large intestine tissue at the molecular level. Namely, the present invention relates to a method for detecting aberrant crypt foci (ACF) that comprises detecting one or more types of molecules for which ACF-specific expression increases selected from the group consisting of GSTp, iNOS, CD44, EGFR, COX2 and Fzd1 present in a test region of large intestine tissue; the aforementioned ACF detection method wherein the diameter of the test region is 0.5 mm or less; a an ACF detection marker that is GSTp, iNOS, CD44, EGFR, COX2 or Fzd1; and, a method for evaluating risk of colorectal cancer and colorectal adenoma in subjects based on the results of detecting ACF in a test region of large intestine tissue of the subjects using the aforementioned ACF detection method. | 2013-05-23 |
20130130257 | MOBILE RAPID TEST SYSTEM FOR NUCLEIC ACID ANALYSIS - A mobile rapid test system for nucleic acid analysis. A method comprising the steps of amplification of the nucleic acids by means of rapid-PCR technology, conversion of a double-stranded amplification product into a single-stranded DNA fragment, hybridization with a labeled probe and detection of the nucleic acids on a lateral-flow test strip. A device comprising a reaction cavity which preferably consists of a thin film, inlet and outlet openings for the reaction cavity, one or more heatable sample blocks which are connected to miniaturized cooling bodies and a window for reading off the result. The lateral-flow test strip is a component of the mobile rapid test system. Operation of the instrument system requires no external power source, but only batteries or a rechargeable battery. | 2013-05-23 |
20130130258 | DETECTION, IDENTIFICATION AND DIFFERENTIATION OF EUBACTERIAL TAXA USING A HYBRIDIZATION ASSAY - The present invention relates to a method for the specific detection and/or identification of | 2013-05-23 |
20130130259 | Methods for evaluating the methylation status of a polynucleotide - The invention provides methods related to evaluating the methylation status of a polynucleotide that includes an internal control. | 2013-05-23 |
20130130260 | Methods to Fix and Detect Nucleic Acids - In one aspect, the invention relates to a method for fixing a short nucleic acid in a biological sample. In another aspect, the invention relates to a method for detecting a target short nucleic acid in a biological sample. The method includes contacting the biological sample with an aldehyde-containing fixative, and subsequently contacting the sample with a water-soluble carbodiimide. In a further aspect, the invention relates to a kit for fixing a short nucleic acid in a biological sample. The kit includes a support substrate for holding the sample; an aldehyde-containing fixative; and a water-soluble carbodiimide. | 2013-05-23 |
20130130261 | CHEMICAL SENSOR - A sensor comprising a memory device having a first electrode and a first chemical-sensing layer coupled to the first electrode. The chemical-sensing layer, in the presence of an analyte, is arranged to change a property of the Memristive device. The sensor can detect an analyte by providing a sample to be detected proximate the chemical sensing layer, observing the state of the memory element; and determining a property of the sample by comparing the observed state of the memory element with a previous state. The sensor is manufactured by depositing a second electrode on a surface, depositing an active layer or layers onto said second electrode, depositing a first electrode onto said active layer(s), and coupling a chemically sensitive layer to the first electrode. | 2013-05-23 |
20130130262 | SAMPLE-TO-ANSWER MICROFLUIDIC CARTRIDGE - A microfluidic cartridge and methods for performing a diagnostic, molecular or biochemical assay thereon, where all dried and/or liquid reagents necessary for the assay are contained in the cartridge and the assay requires only the addition of sample. Pneumohydraulic features, chamber and diaphragm technologies are introduced for overcoming the problems of bubble interference and reagent washout during operation of a microfluidic cartridge. The cartridges are inserted into a host instrument for performance of an assay and the cartridge is supplied as a consumable. | 2013-05-23 |
20130130263 | GAMETES SEPARATION METHODS, COMPOSITIONS AND USES THEREOF - The present invention relates to a method of separating gametes of a subject, which method comprises discriminating a first population of gametes containing an abnormal nucleic acid sequence involved in a genetic disease or in a multifactorial disorder in the offspring of the subject, from a second population of gametes which does not contain said abnormal nucleic acid sequence. The invention further relates to products and compositions which may be used in such a method. | 2013-05-23 |
20130130264 | Methods of Detecting BRAF Mutations in Cancer - The present disclosure relates to detecting BRAF mutations and methods of utilizing BRAF mutations to diagnose cancer. | 2013-05-23 |
20130130265 | METHODS AND DEVICES FOR OBTAINING AND ANALYZING CELLS - A method for concentrating and isolating nucleated cells, such as maternal and fetal nucleated red blood cells (nRBCs), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal genetic testing. The invention also pertains to methods and apparatus for discriminating fetal nucleated red blood cells from maternal nucleated red blood cells obtained from a blood sample taken from a pregnant woman. | 2013-05-23 |
20130130266 | METHODS AND DEVICES FOR OBTAINING AND ANALYZING CELLS - A method for concentrating and isolating nucleated cells, such as maternal and fetal nucleated red blood cells (nRBCs), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal genetic testing. The invention also pertains to methods and apparatus for discriminating fetal nucleated red blood cells from maternal nucleated red blood cells obtained from a blood sample taken from a pregnant woman. | 2013-05-23 |
20130130267 | REACTION VESSEL FOR PCR DEVICE AND METHOD OF PERFORMING PCR - The present invention provides a reaction vessel ( | 2013-05-23 |
20130130268 | EPITOPES OF THE HUMAN PDGF RECEPTOR ABLE TO BIND HUMAN AUTO-ANTIBODIES, ANTIBODIES AND USES THEREOF - The present invention refers to peptides comprised in the extracellular region of human PDGF receptor (hPDGFR) alpha, their use for detecting auto-antibodies anti-hPDGFR alpha and to a method for the diagnosis or the monitoring control for therapy of SSc. The present invention also refers to antibodies or recombinant or synthetic derivatives thereof able to recognize and bind to the above peptide and to their use in the treatment of SSc. | 2013-05-23 |
20130130269 | SCREENING TOOL FOR ANTI-INFLAMMATORY DRUG DISCOVERY COMPRISING THE FPR2/ALX GENE PROMOTER - A screening tool for anti-inflammatory drug discovery and for the detection of the risk or presence of inflammatory conditions, comprising the sequence of the FPR2/ALX gene promoter, is disclosed. | 2013-05-23 |
20130130270 | FILTRATION METHODS AND DEVICES - A method of filtering a liquid sample that includes passing a sample comprising at least one biological organism through a filter membrane at a water volume flux of at least 100 L/m | 2013-05-23 |
20130130271 | POST PROTEIN HYDROLYSIS REMOVAL OF A POTENT RIBONUCLEASE INHIBITOR AND THE ENZYMATIC CAPTURE OF DNA - The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate confining the pathogens and introducing a fibrin lysis reagent to expose the pathogens for analysis. The present invention also concerns materials and methods for removing aurintricarboxylic acid (ATA) from a sample. | 2013-05-23 |
20130130272 | METHOD, REAGENT, AND APPARATUS FOR DETECTING A CHEMICAL CHELATOR - A method for detecting a first chelator (shown in the figure as dipicolinic acid DPA ( | 2013-05-23 |
20130130273 | METHOD FOR DETECTING INTERACTIONS BETWEEN TWO AND MORE BIOLOGICAL MACROMOLECULES - Disclosed is a novel method for detecting interactions of biomolecules. More particularly, the disclosed method includes (a) preparing a cell comprising (i) a first construct comprising a bait, a first labeling material and a translocation module; and (ii) a second construct comprising a prey and a second labeling material; (b) detecting the distribution of the first construct and the second construct in the cell. the present invention provides a method capable of detecting bindings and interactions occurring in a living cell in real time, and a method for screening a material that alters the binding and the interaction. The method of the present invention overcomes the disadvantages including inaccuracy and complexity of existing biomaterial interaction detection techniques. By labeling both constructs to promote accuracy, the present invention provides a novel real-time, antibody-free analysis. | 2013-05-23 |
20130130274 | DETECTION METHOD - A method of analysis of a hydrocarbon fuel for the presence of a micro-organism comprises contacting a fuel sample with an aqueous diluent and with an antibody reactive with the micro-organism, or reactive with a metabolite of breakdown product produced by the micro-organism, to detect the presence or absence of the micro-organism. | 2013-05-23 |
20130130275 | IMMUNOASSAY METHODS AND REAGENTS FOR DECREASING NONSPECIFIC BINDING - Methods and kits for reducing non-specific binding in an immunoassay for PIVKA-II in a test sample are described, in which the test sample is reacted with an anti-prothrombin antibody in the presence of one or more of the following additives: skim milk, saponin, CaCl | 2013-05-23 |
20130130276 | METHOD FOR DETECTING GASTRIC CANCER - The object of the present invention is to provide a method for detecting gastric cancer, and a kit for detecting gastric cancer. The object can be solved by a method for detecting gastric cancer characterized by analyzing β1,4-N-acetylgalactosamine transferase 1. According to the present invention, gastric cancer patients can be detected at high rates, even early stage gastric cancer patients without a subjective symptom. | 2013-05-23 |
20130130277 | REMEDY FOR DIABETES - A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the β subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the β subunit of a trimeric GTP-binding protein, as the active ingredient, etc. | 2013-05-23 |
20130130278 | DETECTION OF RISK FOR PREGNANCY-RELATED MEDICAL CONDITIONS - Generally, there is provided a method of determining risk of determining intrauterine growth restriction (IUGR)/fetal growth restriction (FGR). The method comprises obtaining a sample from a pregnant woman, taking a measurement indicative of IGFBP-4 level in the sample, and determining that increased of IUGR/FGR exists if the IGFBP-4 level is elevated. The sample may be taken during the first trimester of pregnancy, and may comprise maternal serum. The measurement may be one of IGFBP-4 protein which may be made using an immunoassay, such as a Western blot or an enzyme-linked immunosorbent assay (ELISA). | 2013-05-23 |
20130130279 | METHODS FOR DIAGNOSIS, PROGNOSIS AND METHODS OF TREATMENT - The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN. | 2013-05-23 |
20130130280 | MAGNETIC IMMUNODIAGNOSTIC METHODS AND KIT FOR THE DEMONSTRATION OF ANTIBODY/ANTIGEN COMPLEXES IN ERYTHROCYTE BLOOD GROUPING AND PHENOTYPING - The current invention relates to a magnetic immunodiagnostic method for the demonstration of antibody/antigen complexes of blood group and phenotype. Such a method involves the research and/or identification of antibodies or antigens, preferably anti-antigen antibodies or antigens of a blood group. This method implements a suspension of magnetic particles coated with an antibody anti-glycophorin A that can recognize and specifically magnetize erythrocytes. The invention also includes a device and kit for carrying out one such method. | 2013-05-23 |
20130130281 | CYSTEINE PROTEASE Cwp84 (CD2787) AS A DIAGNOSTIC MARKER FOR CLOSTRIDIUM DIFFICILE - Accurate and fast detection of the presence of | 2013-05-23 |
20130130282 | Fibrinogen Assay - The present invention is directed to a method of detecting intact fibrinogen, comprising the steps of: a) providing a sample containing at least some fibrinogen optionally converted at least in part to fibrin, and optionally containing thrombin; b) solubilizing the sample in a solubilizing solution that inhibits thrombin activity; c) after optional SDS-PAGE transferring/applying a portion of said sample to a protein-binding membrane; d) reacting the fibrinogen with a primary monoclonal antibody capable of binding to fibrinopeptide A moiety; and e) detecting the quantity of intact fibrinogen in the sample by quantifying the amount of the bound primary monoclonal antibody. | 2013-05-23 |
20130130283 | Methods for Identifying Inhibitors of the Type III Secretion System - A method for determining whether a test compound has the ability to inhibit the function of the type 3 secretion system. In a first step, the compound is tested for its ability to inhibit secretion of an effector and/or a translocator protein, in a second step, it is further tested for its ability to inhibit the assembly of the structural components to form the needle complex. By this method, drug candidates can be identified that are highly specific anti-bacterial agents for treating diseases caused by Gram-negative bacteria with a T3SS. | 2013-05-23 |
20130130284 | ENZYME-FIBER MATRIX COMPOSITE OF THREE-DIMENSIONAL NETWORK STRUCTURE, PREPARATION METHOD THEREOF, AND USE THEREOF - Disclosed is a composite of enzyme and fiber matrix with three-dimensional structure. The composite of enzyme and fiber matrix with three-dimensional structure includes a significantly large amount of an enzyme loaded in and immobilized in/onto a matrix when compared to conventional composites. In addition, the immobilized enzyme is prevented from leaching from the matrix when an external impact is applied to the composite of enzyme and fiber matrix with three-dimensional structure. Therefore, the stability of the composite of enzyme and fiber matrix with three-dimensional structure of the present invention is maintained even after a long period passes since a remarkably great amount of enzymes compared with a known composite can be supported and immobilized to a matrix, and the immobilized enzyme is not easily released by an external impact. In addition, it is possible to stably immobilize a great amount of enzymes even if a functional group covalently bonding to enzymes is hardly present on the surface of fiber. Therefore, it is possible to remarkably improve performance by using the composite of enzyme and fiber matrix with three-dimensional structure of the present invention in a biosensor, a bio-fuel cell and the like, compared with the case using a known matrix composite. | 2013-05-23 |