21st week of 2016 patent applcation highlights part 25 |
Patent application number | Title | Published |
20160145617 | COMPOSITIONS FOR MODULATING TAU EXPRESSION - Disclosed herein are antisense compounds and methods for decreasing Tau mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate Tau-associated diseases, disorders, and conditions. | 2016-05-26 |
20160145618 | ALBUMIN PRODUCTION AND CELL PROLIFERATION - The present invention provides short activating RNA molecules which up-regulate albumin production. The present invention also provides methods of up-regulating albumin production, such methods involving the use of short activating RNA molecules capable of increasing the expression of albumin. The present invention also provides the use of the short activating RNA molecules in therapy, such as treating or preventing a hyperproliferative disorder and/or a disorder characterised by hypoalbuminemia. | 2016-05-26 |
20160145619 | MULTIVALENT APTAMER COMPLEXES - A compound of the formula A-B-C, is provided, wherein: A is a first nucleic acid that specifically binds to an extracellular surface protein expressed by a cell of interest, B is an alkyl linker; and C is a second nucleic acid that hybridizes to a complementary nucleic acid. In some embodiments, the first nucleic acid is an aptamer. In some embodiments, the nucleic acid comprises an active compound, particularly cytotoxic nucleotides such as poly-FdUMP. Compositions and methods of using such compounds for treating and/or detecting cancer are also described. | 2016-05-26 |
20160145620 | OLIGOMERS WITH IMPROVED OFF-TARGET PROFILE - The present invention provides oligomers that binds RNA that consists of a lower affinity region and a higher affinity region, wherein the monomers in the higher affinity region increases the melting temperature (i.e. affinity) of the oligomer base paired to RNA more than the monomers used in the lower affinity region, wherein said increase in melting temperature is relatively to the alternative use of DNA monomers of the same (base) sequence. The oligomers of the invention are useful for binding to target RNA such as mRNA and non-coding RNA and have the advantage that they will be less prone to off-target binding via the lower affinity region than via the higher affinity region. | 2016-05-26 |
20160145621 | RNAi Agent for Inhibition of Chikungunya Virus - Provided herein are RNAi agents for inhibition of Chikungunya virus. The present disclosure provides RNAi agents for inhibition of Chikungunya virus, particularly by targeting the E2 gene and nsP1 gene or both of the Chikungunya virus; the RNAi agents comprising of the entire nucleotide sequence set forth is SEQ ID 1 or SEQ ID 5 or combination thereof; or comprising of 15 or more contiguous nucleotides as set forth is SEQ ID 1 or SEQ ID 5 or combination thereof along with the addition nucleotides from the contiguous region of the E2 and nsP1 target gene. The invention further provides a RNAi composition for reducing the E2 protein and nsP1 protein level of Chikungunya virus and inhibition of Chikungunya virus replication. The combination of RNAi agents provides an excellent therapeutic composition for treatment of Chikungunya virus infection. | 2016-05-26 |
20160145622 | DENGUE VIRUS-SPECIFIC SIRNA, DOUBLE HELIX OLIGO-RNA STRUCTURE COMPRISING SIRNA, AND COMPOSITION FOR SUPPRESSING PROLIFERATION OF DENGUE VIRUS COMPRISING RNA STRUCTURE - The present invention relates to a dengue virus-specific siRNA, a double-stranded oligo RNA structure comprising the siRNA, and a composition for inhibiting dengue virus replication, which comprises the same, in which the double-stranded oligo RNA structure comprises a hydrophilic compound and hydrophobic compound conjugated to both ends of the double-stranded RNA (siRNA) by a single covalent bond or a linker-mediated covalent bond so that they will be efficiently delivered into cells, and can be converted into nanoparticles by hydrophobic interactions between the double-stranded oligo RNA structures in an aqueous solution. The siRNA included in the double-stranded oligo RNA structure acts specifically on all dengue virus serotypes. The present invention also relates to a method for preparing the double-stranded oligo RNA structure, and a pharmaceutical composition for preventing or treating dengue virus infection, which comprises the double-stranded oligo RNA structure. | 2016-05-26 |
20160145623 | METHOD FOR THE TARGETED KILLING OF CELLS BY NUCLEOTIDE MOLECULES THAT ARE DIRECTED TO mRNA BINDING, AND ALSO NUCLEOTIDE MOLECULES AND APPLICATION KIT FOR SUCH USE - Nucleotide molecules are used for the targeted killing of cells, which bind with a nucleotide sequence to a single region of the mRNA which, according to sequencing analyses, is statistically very rarely subject to a mutation and, thus, also in case of increased mutation rates in the whole genome, reliably kills the cell without further mRNA binding or other influence on the cell being necessary. | 2016-05-26 |
20160145624 | LIVER CANCER RELATED GENES-SPECIFIC siRNA, DOUBLE-STRANDED OLIGO RNA MOLECULES COMPRISING THE siRNA, AND COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME - There is provided a liver cancer related specific siRNA and high efficiency double-stranded oligo RNA molecules containing the same. The double-stranded oligo RNA molecules have a structure in which hydrophilic and hydrophobic compounds are conjugated to both ends of the double-stranded oligo RNA molecules by a simple covalent bond or a linker-mediated covalent bond in order to be efficiently delivered into cells and may be converted into nanoparticles in an aqueous solution by hydrophobic interactions of the double-stranded oligo RNA molecules. The siRNA contained in the double-stranded oligo RNA molecules may be liver cancer related genes, particularly ZBTB7A, YAP1 or CHD1L specific siRNA. | 2016-05-26 |
20160145625 | DNAZYME FOR SILENCING THE EXPRESSION OF EGFR - The invention provides DNAzymes which are capable to silence the expression of EGFR at allele-specific level. These allele-specific DNAzymes against EGFR T790M mutation will knockdown the expression of EGFR T790M mRNA while keeping EGFR wild-type mRNA intact. Hence, these allele-specific DNAzymes against EGFR T790M mutation may overcome T790M-derived TKI resistance accompanied with lower unwanted side effects on normal cells in lung cancer patients. | 2016-05-26 |
20160145626 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF TMPRSS6 GENE - The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the TMPRSS6 gene, and methods of using such dsRNA compositions to inhibit expression of TMPRSS6. | 2016-05-26 |
20160145627 | RNA Interference-Based Therapeutic Against Anthrax - The present invention includes siRNAs and antibodies that block the interaction between TEM8 and/or CMG2 cell surface proteins and anthrax toxin and methods of treating anthrax exposure with the same. | 2016-05-26 |
20160145628 | NANOCARRIER SYSTEM FOR MICRORNAS AND USES THEREOF - Described herein are novel polyglycerol-amine polymeric nanocarriers in complex with microRNAs and their uses in the treatment of cancer, in particular glioblastoma. Delivery of the polymeric nanocarriers in complex with microRNAs in cell lines and in vivo inhibited cell proliferation, cell cycle progression, cell migration and tumor growth. | 2016-05-26 |
20160145629 | TMPRSS6 iRNA COMPOSITIONS AND METHODS OF USE THEREOF - The invention relates to RNAi agents, e.g., double-stranded RNAi agents, targeting the TMPRSS6 gene, and methods of using such RNAi agents to inhibit expression of TMPRSS6 and methods of treating subjects having a TMPRSS6 associated disorder, e.g., an iron overload associated disorder, such as β-thalassemia or hemochromatosis. | 2016-05-26 |
20160145630 | COMPOSITIONS AND METHODS FOR THE IMPROVED PRODUCTION AND DELIVERY OF RNA BY EFFICIENT TRANSCRIPTION TERMINATION - Compositions and methods for efficiently producing and delivering double stranded RNA (dsRNA) are provided. Vector constructs useful for in vitro and in vivo expression of dsRNA are described. Also described are cell expression systems for efficient and cost-effective production of dsRNA in living cells and methods and compositions for providing the expressed dsRNA to target organisms. The described compositions and methods can be used to produce RNA molecules for screening or other uses, and to amplify RNA sequences for analysis. | 2016-05-26 |
20160145631 | METHODS FOR NON-TRANSGENIC GENOME EDITING IN PLANTS - Materials and methods for creating genome-engineered plants with non-transgenic methods are provided herein. | 2016-05-26 |
20160145632 | PLANT TRANSFORMATION WITH IN VIVO ASSEMBLY OF A SEQUENCE OF INTEREST - A process of producing transgenic plants or plant cells stably transformed on a chromosome with a DNA sequence of interest and capable of expressing a function of interest from said DNA sequence of interest, said process comprising (a) providing plant cells or plants with at least two different vectors, whereby (i) said at least two different vectors are adapted to recombine with each other by site-specific recombination in said plant cells for producing a non-replicating recombination product containing said DNA sequence of interest, (ii) said at least two different vectors are adapted for integrating said DNA sequence of interest into said chromosome, (iii) said DNA sequence of interest contains sequence portions from at least two of said at least two different vectors, said sequence portions being necessary for expressing said function of interest from said DNA sequence of interest; and (b) selecting plants or plant cells expressing said function of interest | 2016-05-26 |
20160145633 | WOODY PLANTS HAVING IMPROVED GROWTH CHARACTERISTICS AND METHOD FOR MAKING THE SAME - The present invention pertains to a novel and extensive analytical platform for selecting genes with a possible commercial phenotype from a large group of candidate genes identified using tools in bioinformatics, data from EST sequencing and DNA array. An aspect of the invention provides a method of producing a transgenic plant having an increased growth compared to its wild type. The method comprises altering in the plant the level of a gene product of at least one gene specifically expressed during different phases of wood formation. Further aspects of the invention provide a plant cell or plant progeny of a transgenic plant comprising a recombinant polynucleotide according to the invention. Other aspects pertain a DNA construct comprising a nucleotide sequence of the invention and a plant cell or plant progeny comprising the DNA construct. | 2016-05-26 |
20160145634 | ROOT-PREFERRED PROMOTER AND METHODS OF USE - The present invention provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for a promoter for the gene encoding Sorghum bicolor pLTP. A method for expressing a heterologous nucleotide sequence in a plant using the promoter sequences disclosed herein is provided. The method comprises transforming a plant or plant cell with a nucleotide sequence operably linked to one of the promoters of the present invention. | 2016-05-26 |
20160145635 | KITS COMPRISING PLUS-SENSE SINGLE STRANDED RNA VIRAL VECTORS AND METHODS FOR PRODUCING POLYPEPTIDES USING THE KITS - The present invention relates to kits comprising plus-sense single stranded RNA viral vectors, as well as mixtures of these vectors and uses thereof, and methods for producing in a plant, or plant tissue, or plant cell simultaneously two or more polypeptides using the kits and vectors. | 2016-05-26 |
20160145636 | COMPOSITIONS AND METHODS FOR THE PRODUCTION OF GLUTEN FREE FOOD PRODUCTS - Compositions and methods for the production of baked goods and flour, which do not induce CD are disclosed. | 2016-05-26 |
20160145637 | Abiotic Stress Resistance - Transformed plants are disclosed with enhanced resistance to abiotic stresses, such as salt stress, water stress, or temperature stress. Also disclosed are vectors useful for making such transformed plants, and methods of transforming plants to enhance resistance to abiotic stresses, such as salt stress, water stress, or temperature stress. For example, the | 2016-05-26 |
20160145638 | MUTATED ALLENE OXIDE SYNTHASE 2 (AOS2) GENES - Provided are compositions and methods relating to gene and/or protein mutations in plants. In certain embodiments, the disclosure relates to mutations in the allene oxide synthase 2 gene (i.e., AOS2). In some embodiments the disclosure relates to plants that are pathogen resistant. | 2016-05-26 |
20160145639 | AGENT FOR IMPARTING RESISTANCE TO FEEDING DAMAGE BY PHYTOPHAGOUS ARTHROPOD (As Amended) - An object of the present invention is to develop and provide a method for enhancing the resistance of a plant itself to feeding damage by a phytophagous arthropod. A gene expression system containing, in an expressible state, a gene encoding a variant BIL1/BZR1 protein with a particular point mutation is transferred to a desired plant to thereby impart resistance to feeding damage by a phytophagous arthropod to the plant. | 2016-05-26 |
20160145640 | METHOD FOR PROPAGATING STERILE MALE PLANT LINE - A method for propagating a sterile male plant line includes: (a) providing a first plant that comprises a homozygous recessive male sterility allele; (b) providing a second plant comprising the homozygous recessive allele and a construct, where the construct exists in a heterozygous state and comprises i) a first nucleotide sequence that will restore the male fertility of the first plant after expression, and ii) a second nucleotide sequence that is able to affect the grain shape or the endosperm nutrient material composition in a heterozygous state, which allows for distinguishing the grains with or without said construct by observation through naked eyes or devices; the first nucleotide sequence and the second nucleotide sequence are tightly connected with each other and coexist in plants; and (c) fertilizing the female gametes of the first plant with the male gametes of the second plant. | 2016-05-26 |
20160145641 | STEPWISE DIFFERENTIATION OF STEM CELLS FOR THE PRODUCTION OF EUKARYOTIC MEMBRANE PROTEINS - A method useful for making a eukaryotic membrane protein in vitro may be carried out by (a) propagating in vitro vertebrate stem cells; (b) transforming the vertebrate stem cells in vitro with a heterologous expression vector containing a nucleic acid encoding the eukaryotic membrane protein; and then (c) differentiating the stem cells in vitro into differentiated cells (or photoreceptor-like cells) that express the membrane protein. | 2016-05-26 |
20160145642 | GENERATION OF INDUCED PLURIPOTENT STEM CELLS FROM NORMAL HUMAN MAMMARY EPITHELIAL CELLS - Described herein are reprogramming techniques allowing for production of mammary-derived iPSCs (“m-iPSCs”). The m-iPSCs described herein exhibit all the hallmarks of stem cell identity including round cluster, bright colony morphology, clonal expansion, and pluripotent marker expression (alkaline phosphatase expression, Oct-4, nanog, etc.) Further refined techniques allow for generation of m-iPSCs under essentially defined conditions. | 2016-05-26 |
20160145643 | Endothelial-targeted Adenoviral Vectors, Methods and Uses Therefor - Disclosed are adenovirus vectors comprising a ROBO4 enhancer/promoter operatively linked to a transgene. Also disclosed are adenovirus vectors comprising a chimeric AD5-T4 phage fibritin shaft, a trimerization domain displaying a myeloid cell-binding peptide (MBP), and a ROBO4 enhancer promoter operatively linked to a transgene. Also disclosed are methods of expressing a transgene in an endothelial cell in vivo, comprising administering to a mammal an adenovirus comprising a ROBO4 enhancer/promoter operatively linked to a transgene. Also disclosed are uses of the adenoviral vectors, including mobilization of granulocytes, monocytes and lymphocytes from bone marrow, mobilization of cancer cells in vivo, selective targeting of endothelial cells, and cancer treatment methods. | 2016-05-26 |
20160145644 | TARGETED GENOMIC MODIFICATION WITH PARTIALLY SINGLE-STRANDED DONOR MOLECULES - Disclosed herein are donor molecules comprising single-stranded complementary regions flanking one or more sequences of interest. The donor molecules and/or compositions comprising these molecules can be used in methods for targeted integration of an exogenous sequence into a specified region of interest in the genome of a cell. | 2016-05-26 |
20160145645 | TARGETED INTEGRATION - The present disclosure encompasses an isolated cell comprising an exogenous nucleic acid sequence located within or proximal to a predetermined genomic locus, wherein the exogenous nucleic acid sequence comprises at least one recognition sequence which can be exploited by one or more polynucleotide modification enzymes for targeted integration of a recombinant protein. The disclosure further provides methods for preparing such cells, and methods for retargeting such cells for the production of recombinant proteins, and kits for the same. | 2016-05-26 |
20160145646 | METHODS AND COMPOSITIONS FOR TARGETED GENETIC MODIFICATION USING PAIRED GUIDE RNAS - Compositions and methods are provided for creating and promoting biallelic targeted modifications to genomes within cells and for producing non-human animals comprising the modified genomes. Also provided are compositions and methods for modifying a genome within a cell that is heterozygous for an allele to become homozygous for that allele. The methods make use of Cas proteins and two or more guide RNAs that target different locations within the same genomic target locus. Also provided are methods of identifying cells with modified genomes. | 2016-05-26 |
20160145647 | FERMENTATION PROCESSES WITH REDUCED FOAMING - The present invention relates to processes of producing a fermentation product from readily fermentable sugar-material in a fermentation vat comprising a fermentation medium, comprising: feeding the readily fermentable sugar-material into the fermentation vat comprising a slurry of fermenting organism; fermenting the readily fermentable sugar material into a desired fermentation product, wherein protease is added during or after feeding of the readily fermentable sugar-material into fermentation vat or during fermentation of the readily fermentable sugar-material into the desired fermentation product. The invention also related to the use of protease for reducing foaming in the fermentation yells generating by the fermenting organism during fermentation of the readily fermentable sugar-material. | 2016-05-26 |
20160145648 | ESCHERICHIA COLI CONTAINING MUTATED LPDA GENE AND APPLICATION THEREOF - The invention relates to the field of modifying | 2016-05-26 |
20160145649 | Ethanol Production in Microorganisms - The present disclosure relates to methods and compositions for engineering photoautotrophic organisms to convert carbon dioxide and light into fatty acid esters and other molecules, including biofuels. The molecules are then secreted by the organism into a growth medium. | 2016-05-26 |
20160145650 | CORN BLENDS THAT INCLUDE HIGH OIL CORN AND METHODS OF MAKING ONE OR MORE BIOCHEMICALS USING HIGH OIL CORN OR CORN BLENDS THAT INCLUDE HIGH OIL CORN - The present invention relates to using high oil corn to make a biochemical such as ethanol. More particularly, the invention relates to methods of making a biochemical using relatively low temperature saccharification followed by fermentation or simultaneous saccharification and fermentation of high oil corn. | 2016-05-26 |
20160145651 | METHOD OF PRODUCING SUGAR LIQUID - A method of producing a sugar liquid from biomass includes decomposing a fermentation inhibitor contained in a sugar aqueous solution obtained from biomass with a microorganism incapable of utilizing glucose and/or xylose or a crude enzyme derived from the microorganism, wherein the fermentation inhibitor includes one or more compounds selected from the group consisting of courmaric acid, coumaramide, ferulic acid, ferulamide, vanillin, vanillic acid, acetovanillone, furfural, and 3-hydroxymethylfurfural. | 2016-05-26 |
20160145652 | METHODS FOR INCREASING PRODUCT YIELDS - A non-naturally occurring microbial organism includes a microbial organism having a reductive TCA or Wood-Ljungdahl pathway in which at least one exogenous nucleic acid encoding these pathway enzymes is expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. A method for enhancing carbon flux through acetyl-CoA includes culturing theses non-naturally occurring microbial organisms under conditions and for a sufficient period of time to produce a product having acetyl-CoA as a building block. Another non-naturally occurring microbial organism includes at least one exogenous nucleic acid encoding an enzyme expressed in a sufficient amount to enhance the availability of reducing equivalents in the presence of carbon monoxide or hydrogen, thereby increasing the yield of redox-limited products via carbohydrate-based carbon feedstock. A method for enhancing the availability of reducing equivalents in the presence of carbon monoxide or hydrogen includes culturing this organism for a sufficient period of time to produce a product. | 2016-05-26 |
20160145653 | RECOMBINANT ESCHERICHIA COLI FOR PRODUCING D-LACTATE AND USE THEREOF - Provided is recombinant | 2016-05-26 |
20160145654 | POLYMER PARTICLES AND USES THEREOF - The present invention relates to polymer particles and uses thereof. The polymer particle may comprise a polymer selected from poly-beta-amino acids, polylactates, polythioesters and polyesters. In particular the present invention relates to functionalised polymer particles, processes of production and uses thereof. The methods, polymer particles and fusion proteins of the present invention have utility in diagnostics, protein production, biocatalyst immobilisation, and drug delivery. | 2016-05-26 |
20160145655 | POLYHYDROXYALKANOIC ACID COMPOSITIONS AND METHODS FOR GENERATING SAME - Embodiments of the invention relate to the microbial production of polyhydroxyalkanoic acids, or polyhydroxyalkanoates (PHA), from substrates which cannot be used as a source of carbon and/or energy for microbial growth or PHA synthesis and which have microbial and environmental toxicity. According to one embodiment of the invention, a process for the production of PHA is provided wherein an enzyme such as methane monooxygenase is used to convert volatile organic compounds into PHA through the use of microorganisms that are unable to use volatile organic compounds as a source of carbon for growth or PHA production. | 2016-05-26 |
20160145656 | BIOMASS OF THE MICROALGAE SCHIZOCHYTRIUM MANGROVEI AND METHOD FOR PREPARING SAME - The invention concerns a strain of | 2016-05-26 |
20160145657 | Methods and Materials for Producing 7-Carbon Chemicals via a C9 Route - This document describes biochemical pathways for producing 7-hydroxyheptanoic acid using a polypeptide having monooxygenase activity to form a 8-hydroxynonanoate intermediate, which can be converted to 7-hydroxyheptanoate using a polypeptide having monooxygenase activity, a polypeptide having secondary alcohol dehydrogenase activity, and a polypeptide having esterase activity. 7-hydroxyheptanoic acid can be enzymatically converted to pimelic acid, 7-aminoheptanoic acid, heptamethylenediamine or 1,7 heptanediol. This document also describes recombinant hosts producing 7-hydroxyheptanoic acid as well as pimelic acid, 7-aminoheptanoic acid, heptamethylenediamine and 1,7 heptanediol. | 2016-05-26 |
20160145658 | PROCESS AND COMPOSITION FOR PRODUCTION OF ORGANIC PRODUCTS - The present invention comprises a process to produce organic products from a single-carbon substrate; microbial compositions used in the process; and a process to isolate microorganisms for the process. | 2016-05-26 |
20160145659 | PRODUCING RESINS FROM ORGANIC WASTE PRODUCTS - Producing a resin from an organic waste product includes assessing a weight percent of a first volatile fatty acid and a weight percent of a second volatile fatty acid in a liquid mixture having volatile fatty acids from the organic waste product. The weight percent of the volatile fatty acids is based on the total weight of the carboxylic acids in the liquid mixture, the total weight of volatile fatty acids in the liquid mixture, or the total weight of lactic acid and volatile fatty acids in the mixture. A ratio of the weight percent of the first volatile fatty acid to the weight percent of the second volatile fatty acid in the liquid mixture is adjusted to yield a modified liquid mixture. The modified liquid is combined with polyhydroxyalkanoate-producing bacteria to yield a polyhydroxyalkanoate copolymer; and the polyhydroxyalkanoate copolymer is extracted from the polyhydroxyalkanoate-producing bacteria. | 2016-05-26 |
20160145660 | PRODUCTION OF MICROBIAL OILS - The present invention relates to the | 2016-05-26 |
20160145661 | Microorganism of the Genus Corynebacterium with Enhanced ability to produce L-Arginine and Method for Producing L-Arginine Using the Same (AS AMENDED) - The present invention relates to a microorganism of the genus | 2016-05-26 |
20160145662 | PROCESS FOR THE PREPARATION OF 2,5-FURANDICARBOXYLIC ACID - The invention is directed to a process for the preparation of 2,5-furandicarboxylic acid (FDCA) by fermentation comprising fermenting a suitable starting compound to produce an aqueous solution of a salt of FDCA having a pH of at least 7, optionally removing solids from said solution, e.g. by filtration, subsequently freeze crystallizing the said salt of FDCA from said solution at said pH, isolating the said FDCA salt in the form of solid crystals, preparing an aqueous solution of said salt and crystallizing FDCA as the free acid from said solution at an acidic pH. | 2016-05-26 |
20160145663 | Compositions for saccharification of cellulosic material - The present invention relates to enzyme compositions for high temperature saccharification of cellulosic material and to uses thereof. | 2016-05-26 |
20160145664 | SYNTHESIS OF SIALIC ACID IN PLANTS - A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase. | 2016-05-26 |
20160145665 | METHOD FOR PRODUCING METHACRYLYL-COA - The invention provides a method for producing methacrylyl-CoA that converts 3-hydroxyisobutyryl-CoA into methacrylyl-CoA using an enzyme having dehydratase activity as a method for producing methacrylyl-CoA using an enzyme catalyst. In this production method, conversion rate of 3-hydroxyisobutyryl-CoA into methacrylyl-CoA by the enzyme having dehydratase activity is 50% or higher. In this production method, furthermore, the enzyme having dehydratase activity derives from a microorganism belonging to the genus | 2016-05-26 |
20160145666 | Poly(UG) Polymerase, Constructs, and Methods of Making and Using the Same - Methods, kits, and compositions of matter relating to poly(UG) polymerases are disclosed. In one embodiment, a method includes: contacting an RNA substrate with a poly(UG) polymerase; and allowing the poly(UG) polymerase to add a poly(UG) sequence to the end of the RNA substrate by retaining contact between the RNA substrate and the poly(UG) polymerase for a period of time from about 1 second to about 28 days. The poly(UG) polymerase can be | 2016-05-26 |
20160145667 | Methods For Producing Secreted Polypeptides Having Biological Activity - The present invention relates to methods for producing a polypeptide having biological activity, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first polynucleotide encoding the polypeptide operably linked to a second polynucleotide encoding a variant signal peptide or a variant prepropeptide; and (b) isolating the secreted polypeptide having biological activity from the cultivation medium. | 2016-05-26 |
20160145668 | UNCOUPLED CELL CULTURE METHOD - Disclosed is a method for producing biomass by culturing cells in mixotrophic conditions, in particular in the presence of discontinuous and/or variable lighting conditions, and/or in heterotrophic conditions, making it possible to obtain an increase in both the cellular concentration and the production of molecules of interest. | 2016-05-26 |
20160145669 | Biological supercapacitor structure and method for manufacturing and use of the same - A biological supercapacitor comprising at least one pair of electrodes that comprise immobilized biological materials that includes enzymes. The enzymes are immobilized to the electrodes and may be isolated enzymes, enzyme cascades comprising multiple enzymes, whole cells, organelles from cells, or parts of organelles from cells. An aspect of the disclosed biological supercapacitor is that a byproduct is water. The disclosed biological supercapacitor combines the energy density of a battery with the power density of a supercapacitor in order to reduce the size and weight of the energy storage devices. Methods of fabrication and of use of the biological supercapacitor are also disclosed. | 2016-05-26 |
20160145670 | Microbial Ecology Shift Assay - The disclosure provides assay methods for characterizing the effects of an agent on a microbiome of a subject. Moreover, the disclosure provides methods for practical applications of assay results. The biological sample is extracted and the microbial population is enumerated by using signals or markers specific to the microbial species. The enumerated population is subjected to the action of one or many therapeutic agents and the efficiency is assessed by deriving a score based on the effects in the individual samples and in the population of samples. | 2016-05-26 |
20160145671 | METHOD OF PROCESSING LIQUID BIOLOGICAL MATERIAL - A method of processing liquid biological material includes providing a liquid processing system. The liquid processing system includes a trunk, a first arm, a second arm, a driving mechanism, and physiochemical equipment. The first arm includes a first robot hand. The second arm includes a second robot hand. A process is performed on a cell suspension in which periphytic cultured cells are suspended as a liquid biological material. In the process, a culture vessel is held with the first robot hand in a state with an open top of the culture vessel facing upwards. The culture vessel has a culture face where the cultured cells are cultured on a base thereof. A cell scraper is held with the second robot hand. The cell scraper is provided with a blade to scrape the cultured cells from the culture face. | 2016-05-26 |
20160145672 | PARAOXONASE 1 ENZYMATIC ACTIVITY, A RISK PREDICTOR FOR MAJOR ADVERSE CARDIOVASCULAR EVENTS - Provided herein are methods for assessing the risk a subject or patient without significant evidence of cardiovascular disease has of experiencing a major adverse cardiac event or requiring revascularization near term. Also provided are methods of determining whether a subject who has experienced a major adverse cardiac event is at risk of experiencing a recurrent major adverse cardiac event near term. The present methods comprise determining the levels of paraoxonase 1 enzymatic activity in the blood, serum, plasma, or any combination of said bodily fluids in the subject. | 2016-05-26 |
20160145673 | DETECTING SINGLE NUCLEOTIDE POLYMORPHISM USING OVERLAPPING HYDROLYSIS PROBES - Methods for the rapid detection of the presence or absence of a SNP in a target nucleic acid in a sample are described. The methods can include performing an amplifying step, a hybridizing step utilizing a double stranded probe with two overlapping SNP specific hydrolysis probe sequences where one of the probe sequences can include a hairpin structure toward the 3′ end, and a detecting step. Furthermore, the double stranded SNP specific hydrolysis probes along with kits are provided that are designed for the detection of a SNP in a target nucleic acid. | 2016-05-26 |
20160145674 | NUCLEIC ACID AMPLIFICATION METHOD - A nucleic acid amplification method includes: heating a first region of a nucleic acid amplification reaction vessel filled with a nucleic acid amplification reaction mixture and a liquid which has a specific gravity different from that of the nucleic acid amplification reaction mixture and is immiscible with the nucleic acid amplification reaction mixture to a first temperature; heating a second region of the nucleic acid amplification reaction vessel to a second temperature; switching over from a first arrangement in which the first region is located lower than the second region in the direction of the gravitational force to a second arrangement in which the second region is located lower than the first region in the direction of the gravitational force; and switching over from the second arrangement to the first arrangement, wherein the nucleic acid amplification reaction mixture contains a probe, and the probe contains an artificial nucleic acid. | 2016-05-26 |
20160145675 | NUCLEIC ACID AMPLIFICATION REACTION APPARATUS AND NUCLEIC ACID AMPLIFICATION METHOD - A nucleic acid amplification reaction apparatus includes: a fitting section capable of fitting a reaction vessel filled with a reaction mixture and a liquid which has a specific gravity different from that of the reaction mixture and is immiscible with the reaction mixture; a first heating section which heats a first region of the reaction vessel; a second heating section which heats a second region of the reaction vessel; and a driving mechanism which switches over between a first arrangement in which the first region is located lower than the second region in the direction of the gravitational force and a second arrangement in which the second region is located lower than the first region in the direction of the gravitational force, wherein the concentration of magnesium ions in the reaction mixture is 1.8 mM or more and 9.0 mM or less. | 2016-05-26 |
20160145676 | SYSTEMS FOR BIOAGENT IDENTIFICATION - The present invention provides systems and methods for analysis of samples, particularly biological and environmental sample to detect biomolecules of interest contained therein. A variety of system components are described herein, including, but not limited to, components for sample handling, mixing of materials, sample processing, transfer of materials, and analysis of materials. The invention further provides mechanisms for combining and integrating the different components and for housing, moving, and storing system components or the system as a whole. The systems may include any one or more or all of these components. The system finds particular use when employed for analysis of nucleic acid molecule using mass spectrometry, however, the invention is not limited such specific uses. | 2016-05-26 |
20160145677 | SPATIALLY ENCODED BIOLOGICAL ASSAYS USING A MICROFLUIDIC DEVICE - The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of abundance, expression, and/or activity of one or more biological targets across multiple sites in a sample. In particular, the present disclosure provides methods and assay systems capable of high levels of multiplexing where reagents are provided to a biological sample in order to address tag the sites to which reagents are delivered; instrumentation capable of controlled delivery of reagents, in particular, microfluidic device based instrumentation; and a decoding scheme providing a readout that is digital in nature. | 2016-05-26 |
20160145678 | MULTIPLEX ASSAY FOR THE DETECTION OF AT LEAST TWO CITRUS PATHOGENS - The present invention provides methods and compositions for detecting multiple citrus pathogens using a multiplex branched DNA signal amplification reaction. | 2016-05-26 |
20160145679 | OLIGONUCLEOTIDE FUNCTIONALIZED QUANTUM DOTS - The present invention provides a DNA-functionalized conjugate comprising single-stranded DNA (ssDNA) strands conjugated to a semi-conductor nanoparticle, wherein the nanoparticle provides fluorescent emissions. The present invention also provides a method to efficiently conjugate DNA strands to a wide variety of quantum dots having fluorescent emissions | 2016-05-26 |
20160145680 | METHOD AND APPARATUS FOR DETECTING TRANSLOCATION - Disclosed are a method and an apparatus for detecting a translocation. The apparatus acquires BAM for a first pair of chromosomes and a second pair of chromosomes. Also, the apparatus detects a translocation generated in at least one chromosome by selecting at least one translocation case corresponding to the translocation information produced on the basis of BAM from among multiple translocation cases in which a translocation may be generated in at least one of the first and the second chromosomes. | 2016-05-26 |
20160145681 | METHODS AND MATERIALS FOR ASSESSING ALLELIC IMBALANCE - Methods and systems for detecting allelic imbalance using nucleic acid sequencing are provided. | 2016-05-26 |
20160145682 | METHODS OF MONITORING IMMUNOSUPPRESSIVE THERAPIES IN A TRANSPLANT RECIPIENT - The present disclosure relates to methods of monitoring the status of an allograft in a transplant recipient, as well as to methods of monitoring and adjusting immunosuppressive therapies being administered to the transplant recipient. | 2016-05-26 |
20160145683 | MASSIVELY PARALLEL SINGLE CELL ANALYSIS - The disclosure provides for methods, compositions, and kits for multiplex nucleic acid analysis of single cells. The methods, compositions and systems may be used for massively parallel single cell sequencing. The methods, compositions and systems may be used to analyze thousands of cells concurrently. The thousands of cells may comprise a mixed population of cells (e.g., cells of different types or subtypes, different sizes). | 2016-05-26 |
20160145684 | METHODS OF DETECTING SYNTHETIC URINE AND MATCHING A URINE SAMPLE TO A SUBJECT - Provided herein are methods for determining if a urine sample comprises synthetic urine, methods for matching a urine sample to a subject, and methods for amplifying DNA. Also provided are kits that include a set of at least 3 pairs of a pre-amplification forward and reverse primer, where each pair of pre-amplification forward and reverse primers is designed to amplify 250 to 300 nucleotides of genomic DNA that contains one of at least 3 SNPs, where the pre-amplification forward and reverse primers in each of the three or more pairs of pre-amplification primers contains (i) a sequence of about 17 to about 25 contiguous nucleotides that is complementary to a sequence in the genomic DNA and (i) a tag sequence of about 17 to about 25 contiguous nucleotides that is not complementary to a sequence in the genomic DNA. | 2016-05-26 |
20160145685 | METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS - Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations. | 2016-05-26 |
20160145686 | BIOMARKER FOR SENESCENCE AND USE THEREOF - A biomarker for diagnosing senescence, a composition and a kit for diagnosing a senescence level to detect the same, a method of diagnosing a senescence level in a cell or subject, and a method of screening a senescence inhibitor. | 2016-05-26 |
20160145687 | Method of Predicting Risk for Type 1 Diabetes - The present invention relates to methods, transcriptome profiles and kits useful for determining, before seroconversion, the risk that an individual will develop Type 1 diabetes (T1D). | 2016-05-26 |
20160145688 | Methods and Compositions for Diagnosing Disease - The present invention relates to methods and compositions for diagnosing a disease or disorder in a subject by introducing into cells of the subject a diagnostic gene switch construct and monitoring expression of a reporter gene. The invention further relates to methods and compositions for monitoring the progression of a disease or disorder or the effectiveness of a treatment for a disease or disorder. | 2016-05-26 |
20160145689 | STRATEGIES FOR HIGH THROUGHPUT IDENTIFICATION AND DETECTION OF POLYMORPHISMS - The invention relates to a method for the high throughput identification of single nucleotide polymorphisms by performing a complexity reduction on two or more samples to yield two or more libraries, sequencing at least part of the libraries, aligning the identified sequences and determining any putative single nucleotide polymorphisms, confirming any putative single nucleotide polymorphism, generating detection probes for the confirmed single nucleotide polymorphisms, subjection a test sample to the same complexity reduction to provide a test library and screen the test library for the presence or absence of the single nucleotide polymorphisms using the detection probe. | 2016-05-26 |
20160145690 | Methods of Detecting Prenatal or Pregnancy-Related Diseases or Conditions - This invention provides methods of using phagocytic cells alone or in combination with non-phagocytic cells in the diagnosis, prognosis, or monitoring of prenatal or pregnancy-related diseases or conditions. The invention also provides methods of using phagocytic cells alone or in combination with non-phagocytic cells to identify markers of prenatal or pregnancy-related diseases or conditions. | 2016-05-26 |
20160145691 | NOVEL ESTROGEN RECEPTOR MUTATIONS AND USES THEREOF - Novel mutant ESR1 molecules and uses are disclosed. | 2016-05-26 |
20160145692 | METHODS AND COMPOSITIONS INVOLVING LINCRNA AND LEUKEMIA - The instant disclosure relates to the finding that lincRNA expression is associated with particular cytogenetic abnormalities and is related to disease pathogenesis of certain cancers. Long intergenic non-coding RNAs (lincRNAs) have been found to play a role in gene regulation, but their expression has not been described in B acute lymphoblastic leukemia (B-ALL). Methods and compositions are provided regarding B-ALL associated long intergenic RNAs (BALIRs). | 2016-05-26 |
20160145693 | METHODS FOR THE DIAGNOSIS OF ONCOLOGICAL DISORDERS USING EPIMETABOLIC SHIFTERS, MULTIDIMENSIONAL INTRACELLULAR MOLECULES, OR ENVIRONMENTAL INFLUENCERS - Methods and formulations for diagnosing onocological disorders in humans using epimetabolic shifters, multidimensional intracellular molecules or environmental influencers are described. | 2016-05-26 |
20160145694 | METHOD FOR DETECTING METHYLATION OF COLORECTAL CANCER SPECIFIC METHYLATION MARKER GENE FOR COLORECTAL CANCER DIAGNOSIS - The present invention relates to a method for detecting methylation of the bowel-cancer-specific methylation marker GPM6A (NM_201591, glycoprotein M6A) gene in order to diagnose bowel cancer, and more specifically relates to a method for providing information for diagnosing bowel cancer by detecting the methylation of a bowel-cancer-specific marker gene that is specifically methylated in bowel cancer cells. The method for detecting methylation and a diagnostic composition, kit and nucleic-acid chip according to the present invention can be used to advantage in diagnosing bowel cancer more accurately and quickly than by normal methods as they permit bowel cancer to be diagnosed at the initial genetic transformation step and so allow early diagnosis. | 2016-05-26 |
20160145695 | Epigenetic regulation of fruit trait with rapid periodic thermal shock treatment - A method to improve fruit quality by manipulating the epigenetic trajectory of fruit in a commercially beneficial direction during the growth and ripening stages of the fruit by applying a special thermal stress treatment of the fruit in the field using periodic, rapid, short duration, pulses of heat. The levels of applied thermal stress are meant to keep the growth and ripening on the desired epigenomic trajectory. With such a process, targeted fruit traits may be consistently obtained. | 2016-05-26 |
20160145696 | MICROBIAL MARKERS AND USES THEREFOR - Disclosed are methods for identifying and/or classifying microbes using one or more single nucleotide polymorphisms (SNPs) in 16S ribosomal RNA (16S rRNA) of prokaryotes and/or one or more SNPs in 5.8S ribosomal RNA (5.8S rRNA) of eukaryotes. Also disclosed are probes, primers and kits that are useful in those methods. Methods for the diagnosis of sepsis based upon these SNPs are also disclosed. | 2016-05-26 |
20160145697 | A Method for Determining the Vase Life or Storage History of One or More Cut Flowers, Wherein the Method Comprises Assaying Xylose Concentration or Beta-Xylosidase Expression/Activity - A method for determining the vase life or storage history of one or more cut flowers, wherein the method comprises assaying a test sample obtained from the one or more cut flowers for one or more of: (a) an indicator representative of xylose concentration; (b) an indicator representative of β-xylosidase expression; and (c) an indicator representative of β-xylosidase activity; to determine a value for (each of) the one or more indicators in the test sample. | 2016-05-26 |
20160145698 | PRIMERS AND PROBES FOR DETECTION AND DISCRIMINATION OF EBOLA VIRUS - This invention relates to primers and probes for detecting Ebola virus and one or more subtypes of Ebola virus as well as kits including the probes and primers and methods of using the probes and primers. | 2016-05-26 |
20160145699 | L-ISOLEUCINE-PRODUCING MICROORGANISM AND METHOD OF PRODUCING L-ISOLEUCINE USING THE SAME - The present invention relates to a microorganism having an enhanced ability to produce L-isoleucine and a method of producing L-isoleucine using the same. More specifically, the present invention relates to a | 2016-05-26 |
20160145700 | METHOD FOR HEATING A BLAST FURNACE STOVE - A method for heating a blast furnace stove includes combining flue gas recycling and oxy-fuel combustion for concentrating CO | 2016-05-26 |
20160145701 | STAINLESS STEEL RESISTANT TO DELAYED CRACKING AND A METHOD FOR ITS PRODUCTION - The invention relates to a stainless steel exhibiting transformation-induced plasticity (TRIP) effect resistant to delayed cracking and to the method for producing the stainless steel. The resistance to delayed cracking in the stainless steel is achieved limiting the total hydrogen content of the stainless steel measured by inert gas fusion method below 4 weight ppm, preferably below 3 weight ppm by a heat treatment performed at the temperature range between 100° C. and 700° C. for 0.1-300 hours, preferably at 200-600° C. for 1-100 hours, and more preferably at 250-500° C. for 1-100 hours. | 2016-05-26 |
20160145702 | BEARING STEEL HAVING IMPROVED FATIGUE DURABILITY AND METHOD OF MANUFACTURING THE SAME - Disclose is an alloy composition for bearing steel having improved fatigue durability and a method of manufacturing the bearing steel comprising the same. The alloy composition comprises: based on a total weight of the alloy composition, an amount of about 0.8 to 1.0 wt % of carbon (C), an amount of about 0.35 to 0.9 wt % of silicon (Si), an amount of about 0.5 to 1.0 wt % of manganese (Mn), an amount of about 0.6 to 1.5 wt % of nickel (Ni), an amount of about 1.2 to 1.55 wt % of chromium (Cr), an amount of about 0.2 to 0.5 wt % of molybdenum (Mo), an amount of about 0.01 to 0.06 wt % of aluminum (Al), an amount of about 0.01 to 0.1 wt % of copper (Cu), and iron (Fe) constituting the balance of the weight of the alloy composition. Preferred alloy composition can provide improved strength, hardness, and fatigue life due to spheroidized carbide complex. | 2016-05-26 |
20160145703 | HOT-FORGED TiAl-BASED ALLOY AND METHOD FOR PRODUCING THE SAME - Provided is a hot-forged TiAl-based alloy of the present invention containing 40 to 45 atom % of Al and additive elements in the following composition ratio (A) or (B), and the balance Ti with inevitable impurities: (A) Nb: 7 to 9 atom %, Cr: 0.4 to 4.0 atom %, Si: 0.3 to 1.0 atom %, and C: 0.3 to 1.0 atom %; and (B) at least one of Cr: 0.1 to 2.0 atom %, Mo: 0.1 to 2.0 atom %, Mn: 0.1 to 4.0 atom %, Nb: 0.1 to 8.0 atom %, and V: 0.1 to 8.0 atom %. The TiAl-based alloy is characterized by having a fine structure of densely arranged lamella grains that are laminated alternately with a Ti | 2016-05-26 |
20160145704 | HOT-STAMPED PART AND METHOD OF MANUFACTURING THE SAME - A hot-stamped part includes a chemical composition represented by, in mass %: C: 0.120% to 0.400%; Si: 0.005% to 2.000%; Mn or Cr, or both thereof: 1.00% to 3.00% in total; Al: 0.005% to 0.100%; B: 0.0003% to 0.0020%; P: not more than 0.030%; S: not more than 0.0100%; O: not more than 0.0070%; N: not more than 0.0070%; Ti: 0% to 0.100%; Nb: 0% to 0.100%; V: 0% to 0.100%; Ni: 0% to 2.00%; Cu: 0% to 2.00%; Mo: 0% to 0.50%; Ca or REM, or both thereof: 0% to 0.0300% in total; and the balance: Fe and impurities, and a structure represented by: an area fraction of martensite or bainite, or both thereof: not less than 95% in total; a coverage factor of prior austenite grain boundary by iron-based carbides: not more than 80%; and a number density of iron-based carbides in prior austenite grains: not less than 45/μm | 2016-05-26 |
20160145705 | WEAR-RESISTANT, PARTIALLY UNCOATED STEEL PARTS AND METHODS OF PRODUCING SAME - A wear-resistant steel part may be formed by hot forming and/or hardening a hardenable steel grade semifinished part. The steel part may be used, for example, as a processing, conveying, and/or crushing mechanism in agricultural machines, conveying machines, mining machines, or building machines. The semifinished part may be heated to a temperature above an Ac1 transformation temperature and then subsequently hot formed and/or hardened. The steel part may be particularly suitable for use with abrasive materials. To that end, the steel part may have at least one region that has been hardened to a depth of not more than 100 microns by surface hardening before the semifinished part is hot formed or hardened.” | 2016-05-26 |
20160145706 | HIGH-STRENGTH STEEL SHEET AND MANUFACTURING METHOD THEREFOR - A high-strength steel sheet according to the present invention comprises, by weight, 10.0-15.0% Mn, 6.0-9.0% Al, 0.5-2.0% Cr, 0.8-1.6% C, and 0.001-0.01% N, and further comprises, by weight, 0.02-0.1% V, 0.005-0.015% Nb, and 0.005-0.02% Mo, or further comprises 0.1-0.5 wt % TiAl particles. The high-strength steel sheet has a mixed structure comprising austenite and a fine k-carbide having a mean particle diameter of 10-500 nm. | 2016-05-26 |
20160145707 | Process and Installation for Producing a Press-Hardened Sheet Steel Component - A method and a system for producing a press-hardened sheet steel component is disclosed. The method includes: a) heating of a component blank formed from a hot-formable steel material at least to the austenitising temperature of the steel material by a heating device; b) hot forming of the component blank by a forming tool; c) cooling of the component blank in the forming tool to a temperature above the material-specific martensite finish temperature; d) bringing of the component blank from the forming tool to a warming device; and e) annealing of the component Hank, stabilizing the austenite in the component blank by the warming device. The component blank is brought directly from the forming tool to the waning device, preventing a cooling of the component Hank to less than the material-specific martensite finish temperature. | 2016-05-26 |
20160145708 | METHOD FOR PRODUCING A FLAT PRODUCT FROM AN IRON-BASED SHAPE MEMORY ALLOY - Methods for producing a flat product from an iron-based shape memory alloy may involve casting a melt comprised of iron, alloying elements, and impurities into a strip having a thickness of 1-30 mm and cooling the melt as the strip is formed. A twin-roll caster may be employed to help cool and form the melt into the strip. The resultant flat product is highly resistant to bending and is robust under pressure and torsion. | 2016-05-26 |
20160145709 | HIGH-CARBON HOT-ROLLED STEEL SHEET AND METHOD FOR PRODUCING THE SAME - There is provided is a high-carbon hot-rolled steel sheet and method for producing the same. The steel sheet has excellent hardenability consistently, even when annealed in a nitrogen atmosphere, and excellent formability. The steel sheet has a hardness in the range of 83 HRB or less and a total elongation of 30% or more before being subjected to a quenching treatment. | 2016-05-26 |
20160145710 | HIGH-CARBON HOT-ROLLED STEEL SHEET AND METHOD FOR MANUFACTURING THE SAME - There is provided a high-carbon hot-rolled steel sheet and method for producing the same. The steel sheet has excellent hardenability consistently, even when annealed in a nitrogen atmosphere, and excellent workability. The steel sheet has a hardness in the range of 65 or less in terms of HRB and a total elongation El of 40% or more before a quenching treatment is performed. | 2016-05-26 |
20160145711 | METHOD FOR PRODUCING JOURNAL PART OF 9 TO 12% Cr STEEL TURBINE ROTOR, AND JOURNAL PART PRODUCED BY THE METHOD - In a journal part of a 9 to 12 wt % Cr steel turbine rotor, a groove face is formed, and on the groove face, a lower build-up layer is formed by using a first welding material containing C: 0.10 to 0.25 wt %, Si: 0.20 to 0.80 wt %, Mn: 1.0 to 2.5 wt %, Ni: 0.4 to 1.0 wt %, Cr: 1.0 to 3.0 wt %, Mo: 0.2 to 1.5 wt %, V: 0.03 to 0.10 wt %, and a remainder composed of Fe and inevitable impurities, and further on this lower build-up layer, an upper build-up layer is formed using a second welding material containing C: 0.10 to 0.25 wt %, Si: 0.20 to 0.80 wt %, Mn: 1.0 to 2.5 wt %, Ni: 0.4 to 1.0 wt %, Cr: 1.0 to 3.0 wt %, Mo: 0.2 to 1.5 wt %, and a remainder consisting of Fe and inevitable impurities. | 2016-05-26 |
20160145712 | HIGH CARBON STEEL WIRE ROD AND METHOD FOR MANUFACTURING SAME - A high carbon steel wire rod includes required amounts of chemical components and a remainder including Fe and impurities; in which the area ratio of pearlite in a cross section perpendicular to a longitudinal direction is 95% or more and a remainder includes a non-pearlite structure which includes one or more of a bainite, a degenerate pearlite, a proeutectoid ferrite and a proeutectoid cementite; the average block size of the pearlite is 15 μm to 35 μm and the area ratio of the pearlite having a block size of 50 μm or more is 20% or less; and the area ratio of a region where a lamellar spacing of the pearlite is 150 nm or less is 20% or less in a region within a depth from a surface of the high carbon steel wire rod of 1 mm or less. | 2016-05-26 |
20160145713 | STEEL ROD AND HIGH STRENGTH STEEL WIRE HAVING SUPERIOR DUCTILITY AND METHODS OF PRODUCTION OF SAME - The present invention inexpensively provides with high productivity and good yield a steel rod superior in drawability and a steel wire superior in twistability using the same as a material, that is, draws a high strength steel rod superior in ductility where the chemical components contain C: 0.80 to 1.20%, Si: 0.1 to 1.5%, Mn: 0.1 to 1.0%, Al: 0.01% or less, Ti: 0.01% or less, one or both of W: 0.005 to 0.2% and Mo: 0.003 to 0.2%, N: 10 to 30 ppm, B: 4 to 30 ppm (of which, solute B is 3 ppm or more), and O: 10 to 40 ppm, which has a balance of Fe and unavoidable impurities, has an area percentage of pearlite structures of 97% or more, has a balance of non-pearlite structures, and has a total of the area percentage of the non-pearlite structures and the area percentage of the coarse pearlite structures of 15% or less, to obtain high strength steel wire superior in ductility having a tensile strength of 3600 MPa or more and a number density of voids of lengths of 5 μm or more at the center of 100/mm | 2016-05-26 |
20160145714 | TREATMENT PROCESS FOR EXTRACTION OF PRECIOUS, BASE AND RARE ELEMENTS - This invention describes a hydrometallurgical process for the recovery and separation of valuable elements, in particular gold and silver, from a feed material comprising a refractory, intractable or otherwise poorly responding to conventional treatment routes ores, concentrates and other materials. In particular, the process is a process integrated into one or more existing value element extraction processes. | 2016-05-26 |
20160145715 | TREATMENT PROCESS FOR RECOVERY AND SEPARATION OF ELEMENTS FROM LIQUORS - This invention provides a hydrometallurgical process for extracting one or more saleable products from a sulphate or chloride pregnant leach solution (PLS), or both. The products may be any one or more of the products selected from the group consisting of: precious metals including platinum group metals (PGMs), gold and silver, base metals, and rare metal elements, and metal cathodes, powders, salts or precipitates thereof; sulphur; hydrochloric acid (HCl); calcium; and silica. | 2016-05-26 |
20160145716 | Method for Treating Aluminum Slags - A method for treating aluminum slags in the form of dross or aluminum salt slags obtained in the preparation of aluminum, in which the aluminum slag in the melting process is brought with the exception of the surrounding atmosphere onto a cooling conveyor which is arranged in a housing provided with extraction facilities and whose first section adjoining the supply of the aluminum slag is flushed with an inert gas and whose second section serves for further cooling of the aluminum slag with introduction of air, wherein the lengths of the first section and the second section of the cooling conveyor are designed so that in the first section of the aluminum slag is cooled to a temperature at which the aluminum slag can no longer be chemically changed by exposure to atmospheric oxygen and in the second section, the slag is cooled to a temperature at which the cooled aluminum slag can be processed further to recover the aluminum in the aluminum slag after leaving the cooling conveyor. | 2016-05-26 |