21st week of 2021 patent applcation highlights part 35 |
Patent application number | Title | Published |
20210156823 | METHOD FOR INSPECTION OF POLYMERIC MATERIAL WITH FERROUS REINFORCEMENT TO DETERMINE PRESENCE OF REINFORCEMENT JOINT OR DAMAGE - The present disclosure describes methods of inspecting polymeric material that includes one or more elongated ferrous reinforcements. The method includes applying a magnetic field to any one or more reinforcements. The method further includes positioning an array of magnetic flux sensors near the one or more reinforcements, and detecting the presence of magnetic flux leakage along any of the one or more reinforcements. It is then determined whether the magnetic flux leakage occurs at a damaged location along the one or more reinforcements or at a reinforcement joint. | 2021-05-27 |
20210156824 | ONLINE ANALYZERS FOR FLARE GAS PROCESSING - A method includes receiving data characterizing a speed of an acoustic signal through a gas mixture in a pipe. The speed of the acoustic signal can be detected by an ultrasonic flow meter coupled to the pipe. The method also includes receiving data characterizing a concentration of one or more inert gases in the gas mixture detected by an inert gas analyzer. The method further includes determining, based on the received data characterizing the speed of the acoustic signal and the received data characterizing the concentration of the one or more inert gases in the gas mixture, a net heating value of the gas mixture. The method also includes adjusting a processing of the gas mixture based on the determined net heating value. | 2021-05-27 |
20210156825 | COMOLDED NON-DESTRUCTIVE INSPECTION STANDARD FUNCTIONING AS A BOND BUMP - An inspection feature for an adhesive bond portion between parts of a component comprising the inspection feature extending from a surface of the part of the component a predetermined bond line thickness, the inspection feature having a density configured to imitate a defect of the adhesive bond portion responsive to a non-destructive inspection scan. | 2021-05-27 |
20210156826 | SAMPLE INJECTION FOR LIQUID CHROMATOGRAPHY USING SPLIT SOLVENT FLOW - Described herein are a selectable flow restriction device and a fluidic network for chromatographic sample dilution during injection. A selectable flow restriction device is used in combination with a splitter to define an adjustable splitter for separating a high-pressure solvent flow into two separate solvent flows having the same solvent composition. The first solvent flow passes to a sample manager where a sample is injected as a discrete fluidic plug at an injection valve into a flow comprising at least one solvent. The second solvent flow is merged downstream from the location of injection with the first solvent carrying the sample fluidic plug. The second solvent flow dilutes the sample plug during the mixture of the two solvent flows. | 2021-05-27 |
20210156827 | GRADIENT PROPORTIONING VALVE - Disclosed is a gradient proportioning valve for liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of conduits internal to the manifold, each of the plurality of conduits receiving fluid through a respective one of the plurality of inlet ports, an actuation mechanism having a piston located within a bored structure surrounding the piston, the actuation mechanism configured to open and close at least one of the plurality of conduits in a controlled manner where the piston and the bored structure have a tight tolerance configured to create a fluid tight seal, and a common outlet port configured to receive the fluid composition. | 2021-05-27 |
20210156828 | PASSIVE DAMPENING GRADIENT PROPORTIONING VALVE - Disclosed is a gradient proportioning valve for liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of fluid conduits internal to the manifold, each of the plurality of fluid conduits receiving fluid through a respective one of the plurality of inlet ports, each of the plurality of fluid conduits operatively communicable to a respective actuation mechanism configured to open and close each of the plurality of fluid conduits in a controlled manner, a common outlet port configured to receive the fluid composition, and a passive fluidic dampening system configured to dampen unwanted fluidic pressure pulses in the manifold where at least one of the plurality of fluid conduits is compliant. | 2021-05-27 |
20210156829 | ACTIVE DAMPENING GRADIENT PROPORTIONING VALVE - Disclosed is a gradient proportioning valve for use in liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of conduits internal to the manifold, each of the plurality of conduits receiving fluid through a respective one of the plurality of inlet ports, each of the plurality of conduits operatively communicable to a respective actuation mechanism configured to open and close each of the plurality of conduits in a controlled manner, a common outlet port configured to receive the fluid composition, and an active fluidic dampening system configured to dampen unwanted fluidic pressure pulses in the manifold. Liquid chromatography systems and methods are further disclosed. | 2021-05-27 |
20210156830 | CHARACTERIZATION OF SOLID CATALYSTS - Examples described herein provide a method for characterizing a catalyst in a chemisorption unit. The method includes treating a catalyst sample with gas blend comprising ammonia in an inert gas and performing a first temperature programmed desorption (TPD) to desorb the ammonia from the catalyst sample. A temperature programmed reduction (TPR) of the catalyst sample is performed with hydrogen. The catalyst sample is treated after the TPR with a gas blend comprising ammonia in an inert gas. A second temperature programmed desorption is performed to desorb the ammonia from the catalyst sample. | 2021-05-27 |
20210156831 | BIOLOGICAL SAMPLE ANALYSIS SYSTEM - A data storage section stores LC/MS analysis data for a large number of culture-medium samples acquired with an LC-MS. Based on those data, a quantitative analyzer calculates concentration values of a large number of compounds in each sample and stores the result in an analysis result storage section. A result display processor retrieves analysis results with the same culture name and different sampling date from the analysis result storage section, creates a table in which concentration values are arranged for each compound and for each sampling date, as well as a graph showing a temporal change in the concentration value of one compound, and displays the table and graph on the same window on a display unit. An operator using an operation unit selects a compound on the displayed table. The result display processor creates a graph for the selected compound and renews the graph on the display. | 2021-05-27 |
20210156832 | QUALITY CONTROL REAGENTS AND METHODS - The present invention provides reagents for instrumentation quality control and methods of use thereof. In particular, sets of peptides or other molecules are provided for evaluating the performance of instruments with mass spectrometry (MS) and/or liquid chromatography (LC) functionalities. | 2021-05-27 |
20210156833 | METHOD AND SYSTEM FOR TESTING AND CALIBRATING GAS SENSORS - A system including one or more gas sensor assemblies having one or more gas sensors. The gas sensor is for sensing a preselected gas. The gas sensor assembly includes a housing with a cavity therein, and the sensor is mounted on the housing so that the sensor is able to detect the preselected gas in the cavity. The gas sensor assembly includes a sensor control module in communication with the gas sensor, and also in communication with a central controller. Via the central controller, the sensor may be tested using a purge gas, and the sensor may be zeroed if necessary. Also, via the central controller, the sensor may be calibrated using a calibration gas mixture having the preselected gas in a known concentration. The central controller is configured for manual or automatic testing and calibration. Accordingly, the testing and calibration, whether manual or automatic, is done remotely. | 2021-05-27 |
20210156834 | SECURE DATA HANDLING IN A BREATH ALCOHOL CALIBRATION STATION - A breath alcohol device calibration system includes a computerized calibration module operable to calibrate a breath alcohol device, and an interface operable to couple the breath alcohol device to a remote server. The interface uses a connection employing a cryptographic function such that data stored on the breath alcohol device can be securely transferred from the breath alcohol device to the remote server using the calibration system. The interface is further operable to transfer data stored on the breath alcohol device from the breath alcohol device to the remote server directly without storing the data in nonvolatile storage on the calibration station. | 2021-05-27 |
20210156835 | Creating Mass Flow Parity in a Variant Multi-Channel Sampling System - An equal mixture of gas flows from multiple inputs is provided to gas analysis instrumentation, despite the unequal gas flow properties of the inputs often seen in practice. E.g., due to unequal input sample line lengths. We provide gas flow symmetry into a gas manifold that provides the output(s) to the gas analysis instrument(s). Such symmetry has two parts—equal gas flow properties from a set of reference points (one reference point for each input) to the manifold, and equal pressures at the reference points. Such equal pressures can be provided for unequal input gas flow properties by having a bypass valve for each input controlled so as to equalize the pressures. | 2021-05-27 |
20210156836 | GAS SENSOR DEVICE FOR DETECTING GASES WITH LARGE MOLECULES - The present disclosure is directed to a gas sensor device that detects gases with large molecules (e.g., a gas with a molecular weight between 150 g/mol and 450 g/mol), such as siloxanes. The gas sensor device includes a thin film gas sensor and a bulk film gas sensor. The thin film gas sensor and the bulk film gas sensor each include a semiconductor metal oxide (SMO) film, a heater, and a temperature sensor. The SMO film of the thin film gas sensor is an thin film (e.g., between 90 nanometers and 110 nanometers thick), and the SMO film of the bulk film gas sensor is an thick film (e.g., between 5 micrometers and 20 micrometers thick). The gas sensor device detects gases with large molecules based on a variation between resistances of the SMO thin film and the SMO thick film. | 2021-05-27 |
20210156837 | SENSOR THAT DETECTS AN ANALYTE IN THE PRESENCE OF AN INTERFERING STIMULUS - A sensor includes a first sensing element electronically sensitive to an analyte and to an interfering stimulus. The first sensing element provides a first electrical signal in response to a presence of the analyte and/or the interfering stimulus. The sensor also includes a second sensing element electronically sensitive to the analyte and to the interfering stimulus. The second sensing element provides a second electrical signal in response to the presence of the analyte and/or the interfering stimulus. A conductive link electrically connects the first sensing mechanism and the second sensing mechanism. An electrical property is measured within the sensor that is indicative of a concentration of the analyte based on the first electrical signal and the second electrical signal. | 2021-05-27 |
20210156838 | MODULAR SENSOR ARCHITECTURE FOR SOIL AND WATER ANALYSIS AT VARIOUS DEPTHS FROM THE SURFACE - A method of analyzing soil using a modular sensor device. The modular sensor device including a sensor bus head, a sensor bus terminus, and a sensor rod in a stacked arrangement. The sensor rod disposed between the sensor bus head and the sensor bus terminus. The method including setting on an output pin of the sensor bus. The method further including, subsequent to setting the output pin of the sensor bus, detecting a transition on an input pin of the sensor rod, the output pin of the sensor bus and the input pin of the sensor rod being part of a daisy chain. The method further including, in response to detecting the transition at the input pin of the sensor rod, enabling bidirectional communication between the sensor rod and the sensor bus head over a communication bus electrically coupling the sensor bus head to the sensor rod. | 2021-05-27 |
20210156839 | COMPOSITIONS AND METHODS FOR DIAGNOSING PARASITIC INFECTIONS - Provided herein are compositions and methods for diagnosing parasitic infections. In particular, provided herein are compositions and methods for preparing samples (e.g., canine fecal samples) and performing Raman spectroscopy detection of parasites infections in the samples. | 2021-05-27 |
20210156840 | CRYPTIC ANTIBIOTICS AND METHODS FOR DETECTING BIOACTIVE CRYPTIC METABOLITES - Bacteria harbor an immense reservoir of potentially new and therapeutic small molecules in the form of “silent” biosynthetic gene clusters. These clusters can be identified bioinformatically but are at best sparingly expressed under normal laboratory growth conditions; their products are therefore not interrogated during bioactivity screening exercises. An estimated 80-90% of biosynthetic loci are silent, meaning that routine bioactivity screens miss the majority of microbial biosynthetic potential. Disclosed herein is a method that allows access to this vast hidden metabolome, thereby allowing researchers to screen the complete metabolomes of microorganisms in the search of new therapeutic leads. The disclosed approach, “Bioactivity-HiTES”, broadly activates the secondary metabolomes of bacteria and links the cryptic metabolites produced to a desired biological activity. Using the disclosed method, induction of cryptic antibiotics was detected in all four actinomycete bacterial strains that were tested as proof-of-concept. Follow-up in two cases demonstrated the production of two new antibiotics: In one case, the taylorflavins, pyrimidine antibiotics that harbor selective growth-inhibitory activity toward Gram-negative bacteria, were identified. For example, taylorflavin B shows potent minimal inhibitory concentration toward | 2021-05-27 |
20210156841 | CYTODIAGNOSIS DEVICE AND CYTODIAGNOSIS METHOD - A cytodiagnosis method includes a preparation step, a first injection step, a first discharge step, a second injection step, a second discharge step, a contact step of bringing a filter and a pressing member into contact with each other after the second discharge step, a flattening step of flattening the fine undulations of the filter by pressing the filter with the pressing member after the contact step, and an observation step of observing the cells on the filter flattened by the flattening step with an observation unit while illuminating the filter with a light source while the filter is located between the light source and the observation unit. | 2021-05-27 |
20210156842 | DEVICES AND METHODS FOR PLASMA SEPARATION AND STORAGE - A centrifugal cartridge or disk used for extraction of light supernatant fractions from fluid samples is described, particularly for non-homogenous fluid biological samples such as whole blood. The device may be used to collect cell-free blood plasma or a fraction of whole blood containing target cells such as leukocytes. Single or multiple channels are described, including channels with passive valves, gaskets, receiving cavities, inlet holes, capillary wicking ridges, distal cavities for cell retention, separator gel, and density medium. Centrifugal action causes whole blood in a receiving cavity to pass into one or more channels where it separates into blood cells, plasma and optionally fractions of an intermediate density. After spin, the plasma returns to the receiving cavity by way of the one or more channels for extraction through the inlet hole or other inwardly located hole. Disposable cartridges are constructed of monolithic top and bottom plates, which may be joined together by an elastomeric outer seal. | 2021-05-27 |
20210156843 | BREATH SENSING DEVICE FOR A PORTABLE ELECTRONIC DEVICE - The invention relates to a breath sensing devices for a portable apparatus, in particular a portable telecommunication device or a wearable device, the sensing device comprising an acoustic wave sensing means, like a microphone; and a gas sensing means, The invention furthermore relates to an electronic device comprising such a sensing device. In addition, methods are provided that allow calibrating a gas volume based on an output signal of an acoustic wave sensing means. | 2021-05-27 |
20210156844 | TMEM16A Modulation for Diagnostic or Therapeutic Use in Pulmonary Hypertension (PH) - Provided is a method of assessing the occurrence or the risk of occurrence of pulmonary hypertension (PH), in which an increased level of expression of the channel TMEM16A indicates a risk of occurrence of PH. Provided is also a method of treating PH, in which a compound effective in reducing activity of TMEM16A is being administered. Provided are also screening methods for a compound suitable for modulating activity ex vivo and in vitro and for PH treatment in vivo. | 2021-05-27 |
20210156845 | METHOD FOR DETECTING HUMAN INGESTED SUBSTANCE AND INGESTION TIMES - A method for detecting ingestion times comprises the following steps: obtaining hair samples or nail samples; sampling hair samples or nail samples per unit length, and judging whether the target ingested substance and its metabolites are present in each sample; and counting times of detected target ingested substance and its metabolites as the ingestion times. | 2021-05-27 |
20210156846 | MICROFLUIDIC PLATFORM FOR TARGET AND BIOMARKER DISCOVERY FOR NON-ALCOHOLIC FATTY LIVER DISEASE - A method for developing stratified medicine for nonalcoholic fatty liver disease (NAFLD includes obtaining a microphysiological system (MPS) comprising a liver tissue cytoarchitecture, adipose tissue, or both. The method includes inducing metabolic dysfunction representing NAFLD in the liver or adipose tissue of the MPS. The method includes generating, based on inducing the metabolic dysfunction, transcriptomics data for the MPS. The method includes applying a drug to the MPS using a dosing regimen. The method includes monitoring changes in the transcriptomics data based on applying the drug. The method includes generating a model relating the changes in the transcriptomics data to the dosing regimen of the drug. | 2021-05-27 |
20210156847 | METHODS AND USES OF ENZYMATIC LABELING OF ADP-RIBOSE CONTAINING MOLECULES - Described is ELTA (Enzymatic Labeling of Terminal ADP-ribose) to label free, protein-conjugated, or nucleic acid-conjugated ADP-ribose monomer and polymers at their 2′-OH termini. When coupled with different chemical analogs, ELTA can be used for various applications including fluorescence-based biophysical measurement of PAR-protein interaction, detection of PAR length from cells, and enrichment of ADP-ribosylated peptides for mass spectrometry identification. | 2021-05-27 |
20210156848 | MODULAR POINT-OF-CARE DEVICES, SYSTEMS, AND USES THEREOF - The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications. | 2021-05-27 |
20210156849 | ANALYTICAL METHOD, REAGENT KIT AND ANALYTIC DEVICE - According to one embodiment, an analytical method of detecting a target substance in a sample, includes mixing a) a first substance containing a stimuli-sensitive macromolecule and an environment-responsive fluorescent substance, b) a second substance containing a first capturing body, and c) a third substance containing a second capturing body labeled with an aggregation inhibitor which inhibits aggregation of the stimuli-sensitive macromolecule, with the sample, maintaining the mixture under such a condition that the stimuli-sensitive macromolecule aggregates, detecting fluorescence from the environment-responsive fluorescent substance, and determining presence/absence or quantity of the target substance in the sample. | 2021-05-27 |
20210156850 | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE - The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in sepsis patients . In particular, the invention relates to using assays that detect one or more biomarkers selected from the group consisting of Insulin-like growth factor-binding protein 7, Beta-2-glycoprotein 1, Metalloproteinase inhibitor 2, Alpha-1 Antitrypsin, Leukocyte elastase, Serum Amyloid P Component, C—X—C motif chemokine 6, Immunoglobulin A, Immunoglobulin G subclass I, C—C motif chemokine 24, Neutrophil collagenase, Cathepsin D, C—X—C motif chemokine 13, Involucrin, Interleukin-6 receptor subunit beta, Hepatocyte Growth Factor, CXCL-1, -2, -3, Immunoglobulin G subclass II, Metalloproteinase inhibitor 4, C—C motif chemokine 18, Matrilysin, C—X—C motif chemokine 11, and Antileukoproteinase as diagnostic and prognostic biomarker assays of renal injury in the sepsis patient. | 2021-05-27 |
20210156851 | MAGNETIC GRADIENT CONCENTRATOR/RELUCTANCE DETECTOR FOR MOLECULE DETECTION - Disclosed herein are devices for molecule detection and methods for using detection devices for molecule detection, such as nucleic acid sequencing. In some embodiments, a detection device comprises one or more pole pieces, one or more sensors, each of the one or more sensors coupled to at least one of the one or more pole pieces, and detection circuitry coupled to the one or more sensors. The detection circuitry is configured to detect a characteristic of each of the one or more sensors, the characteristic indicating presence or absence of one or more magnetic nanoparticles (MNPs) coupled to at least one of a plurality of molecules to be detected, and at least one of the one or more pole pieces is operable to draw the one or more MNPs toward at least one of the one or more sensors. | 2021-05-27 |
20210156852 | COMBINED IMMUNOASSAY AND MAGNETIC IMMUNOASSAY METHODS FOR EXTENDED RANGE OF SENSITIVITY - The present invention relates to methods that utilize a combination of immunoassay and magnetic immunoassay techniques to detect an analyte within an extended range of specified concentrations. In particular, a method includes forming, in a biological sample, a first complex of signal antibodies and analyte, and a second complex of the first complex and capture antibodies immobilized on magnetic beads, and contacting a first immunosensor with the biological sample to form a third complex localized on or near a surface of the first immunosensor. The first immunosensor includes an immobilized layer of capture antibodies configured to bind to the analyte, and the third complex includes the first complex bound to the immobilized layer of capture antibodies. The method further includes contacting a magnetic field localized around a second immunosensor with the biological sample such that the second complex is localized on or near a surface of the second immunosensor. | 2021-05-27 |
20210156853 | Devices, kits and methods for detecting misfolded proteins - The invention discloses a device, a kit and a method for determining whether a biological sample contains misfolded protein or misfolded protein aggregates. The detection device comprises a testing component and a sample applicator, the testing component comprises one or more microporous membranes, and the sample applicator comprises one or more capillary tubes. The kit comprises a dye that is capable of binding to misfolded proteins and microporous membranes. During the detection, the sample to be tested is mixed with the dye to form a mixture. The mixture is taken up by a capillary tube. The liquid outlet of the capillary tube is then place in close contact with the surface of a microporous membrane, allowing the mixture to be drawn from the capillary tube into the microporous membrane. The presence or absence of misfolded proteins in the test sample is determined based on the diffusion of the dye in the membrane, as observed by naked eyes or using an instrument. | 2021-05-27 |
20210156854 | ASSAY TO DETERMINE IN VIVO RECEPTOR OCCUPANCY - The present invention relates to assays for monitoring and measuring the binding of a drug of interest to a receptor. In this assay, a blood sample collected from a subject dosed with the compound of interest is incubated with a lysis solution containing a quencher. The drug bound and quencher bound receptor is then isolated from the lysed blood sample. The isolated drug bound and quencher bound receptor is digested to generate surrogate drug bound and quencher bound peptides. The amount of surrogate peptides is determined. Receptor occupancy can be determined by comparing the amount of drug bound surrogate peptide to the total of drug bound and quencher bound surrogate peptide. | 2021-05-27 |
20210156855 | METHODS AND APPARATUS FOR SAMPLE ANALYSIS USING LATERAL FLOW - Methods and assays for performing a lateral flow test are disclosed. A sample is applied to a receiving portion of a lateral flow device such that the sample flows to at least a first test zone and a second test zone. First and second signals levels at the first and second test zones over an assay period are monitored. If a first analyte of interest is present in the sample, the first analyte is labelled and the presence of labelled first analyte in the sample causes one of the first and second signals levels to increase during the assay period. A change between the first and second signal levels over a period of time during the assay period is monitored. The sample can be incubated prior to application to the receiving portion to provide homogeneity to labelling and therefore a substantially linear increase of the signal level at one of the test zones and a substantially constant signal level at the other one of the test zones. | 2021-05-27 |
20210156856 | SYSTEMS, DEVICES, AND METHODS FOR AMPLIFYING SIGNALS OF A LATERAL FLOW ASSAY - Lateral flow assay devices, systems, and methods described herein detect analyte present in a sample in low quantity or at low concentration by amplifying a signal generated at a detection zone. The generated signal can exceed a detection threshold of a measurement system and increase the sensitivity of the lateral flow assay devices, systems, and methods. In one aspect, the lateral flow device includes a signal-amplification conjugate that binds to a complex bound to immobilized capture agent in the detection zone, causing a chain reaction of binding events in the detection zone that result in an amplification of the signal generated in the detection zone. | 2021-05-27 |
20210156857 | Immunoassay Methods Utilizing Trapping Conjugate - Methods are provided for determining the presence of a first ligand in a sample. In some embodiments depletion conjugates are used to deplete the ligands different from but related to the first ligands from the sample. In some embodiments, interim binding agents are used to enhance the test signal. | 2021-05-27 |
20210156858 | RAPID TEST FOR LYME BACTERIA - The subject matter disclosed herein provides a method and a device for detection of one or more bacteria in a sample. | 2021-05-27 |
20210156859 | COMBINATION TREPONEMAL AND NON-TREPONEMAL SYPHILIS TEST - Provided herein are multiplex assays for detecting antibodies indicative of presence and stage of syphilis infection in an individual. Individuals infected with syphilis produce antibodies directed to syphilis components and the lipid cellular debris associated with the infection. The present disclosure represents the first combination of these diverse antibody targets in a single assay. | 2021-05-27 |
20210156860 | SYSTEMS AND METHODS FOR RAPID DIAGNOSTIC FOR VARIOUS CANCERS - A method for setting a threshold for basal levels of QSOX1-L in urine comprising: Storing de-identified urine from 100 BC patient samples and from 100 patients with non-malignant conditions; serially diluting the patient samples with a blocking buffer in triplicate followed by incubation in ELISA plates coated with anti-QSOX-L capture Ab; after 1-hour incubation at 37 C, washing plates followed by addition of biotinylated anti-QSOX-L detection antibody; using Streptavidin-HRP to generate dose dependent signal; obtaining a standard curve for each plate using recombinant QSOX1-L protein spiked into urine that has been depleted of QSOX1-L using affinity chromatography column conjugated with anti-sera against 100aa peptide; calculating concentrations of QSOX1-L based on a standard curve for each plate; and calculating a mean concentrations, ±2 SD to establish a reference range for QSOX1-L levels in urine from patients and individuals without malignant disease. | 2021-05-27 |
20210156861 | METHOD FOR TREATING NEOADJUVANT CHEMOTHERAPY-INDUCED METASTASIS - Methods of reducing chemotherapy-induced metastasis, or chemotherapy-induced cancer cell dissemination, for patients subject to chemotherapy using Tie-2 inhibitors. Methods of reducing chemotherapy-induced metastasis, or chemotherapy-induced cancer cell dissemination, for patients subject to chemotherapy using inhibitors of Mena expression and/or function are also provided. | 2021-05-27 |
20210156862 | MOLECULAR VIBRATIONAL SPECTROSCOPIC MARKERS FOR DETECTION OF CANCER - Methods of detecting diagnostic biomarkers on cancer-derived extracellular vesicles such as exosomes by mid-infrared spectroscopy are provided. In particular, methods of detecting ovarian cancer by spectral fingerprint analysis of molecular vibrational spectroscopic markers on individual or subpopulations of extracellular vesicles are disclosed. | 2021-05-27 |
20210156863 | CANCER DETECTION, CLASSIFICATION, PROGNOSTICATION, THERAPY PREDICTION AND THERAPY MONITORING USING METHYLOME ANALYSIS - There is described herein a method of detecting the presence of DNA from cancer cells in a subject comprising: providing a sample of cell-free DNA from a subject; subjecting the sample to library preparation to permit subsequent sequencing of the cell-free methylated DNA; optionally denaturing the sample; capturing cell-free methylated DNA using a binder selective for methylated polynucleotides; sequencing the captured cell-free methylated DNA; comparing the sequences of the captured cell-free methylated DNA to control cell-free methylated DNAs sequences from healthy and cancerous individuals; identifying the presence of DNA from cancer cells if there is a statistically significant similarity between one or more sequences of the captured cell-free methylated DNA and cell-free methylated DNAs sequences from cancerous individuals. | 2021-05-27 |
20210156864 | Diagnostic and Therapeutic Biomarkers in Human Cancers and Methods of Use Thereof - Methods of analyzing a sample, diagnosing a cancer, and a treating a patient are described. Various markers for cancers, including triple negative breast cancer, are disclosed. | 2021-05-27 |
20210156865 | METHODS FOR ASSESSING EFFICACY OF MALT1 INHIBITORS USING AN NF-KB TRANSLOCATION ASSAY - Methods and reagents for determining treatment efficacy of a MALT1 inhibitor in a human subject are described. The method involves determining NF-κB nuclear translocation in stimulated PBMCs of a blood sample obtained from the subject. The method provides information for guiding treatment decisions for those subjects receiving a MALT1 inhibitor therapy, improves the accuracy of optimizing therapy, reduces toxicity, and/or monitors the efficacy of therapeutic treatment. | 2021-05-27 |
20210156866 | DETECTION OF IMMUNE CHECKPOINT MOLECULES BY DEGLYCOSYLATION - Provided herein are methods of detecting glycosylated proteins, such as immune checkpoint proteins. Further provided are methods of treating cancer, such as by administering immune checkpoint inhibitors. | 2021-05-27 |
20210156867 | QUINOLINE BASED CYANINE DYE TURN-ON FLUORESCENT PROBES AND METHODS OF USE THEREOF - This invention is directed to a turn-on fluorescent probe, wherein said probe comprises a quinoline based cyanine dye derivative (QBC) and a specific protein binder covalently attached thereto directly or via a linker. This invention is further directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins. This invention further describes methods for using these turn-on probes and compounds for detecting and labelling a wide range of proteins in their native environment. | 2021-05-27 |
20210156868 | COMPOSITIONS AND METHODS FOR DETECTING ALBUMIN - The present disclosure provides a method for determining the amount of albumin in a sample. In one embodiment, the method involves treating the sample with an esterase inhibitor that selectively inhibits non-albumin esterase activity; combining the sample with a selective substrate of albumin, which has a carboxylic ester bond, so that the carboxylic ester bond is cleaved to generate a hydrolysate; detecting the amount of the hydrolysate generated in a period of time; and determining the amount of the albumin in the sample based on the amount of the hydrolysate in the period of time. | 2021-05-27 |
20210156869 | RADICAL DOSIMETRY METHODS FOR IN VIVO HYDROXYL RADICAL PROTEIN FOOT-PRINTING - Flash Photo-Oxidation Device and Higher Order Structural Analysis is employed for higher order structural analysis of biomolecules. Biomolecular higher order structure (HOS) results from the confounded superimposition of a biomolecule's secondary, tertiary, and quaternary structure and defines the manner in which a biomolecule presents itself and interacts with other biomolecules in living systems. A rapidly growing class of therapeutic drugs, known as biotherapeutics, comprises a variety of proteins, whose therapeutic properties are inherently linked and dependent upon their HOS. As such, HOS analysis of biotherapeutics is an important analytical requirement in the biopharmaceutical industry. The present invention provides new means and methods for the determination of biopharmaceutical HOS and associated conformation using improved devices and methodologies for flash photo-oxidation of proteins to determine their higher order biomolecular structure, and such is responsive to the increased demand for new and improved HOS analytical means in the biopharmaceutical industry. | 2021-05-27 |
20210156870 | BIOMARKERS AND METHODS FOR PREDICTING PREECLAMPSIA - The disclosure provides biomarker panels, methods and kits for determining the probability for preeclampsia in a pregnant female. The present disclosure is based, in part, on the discovery that certain proteins and peptides in biological samples obtained from a pregnant female are differentially expressed in pregnant females that have an increased risk of developing in the future or presently suffering from preeclampsia relative to matched controls. The present disclosure is further based, in part, on the unexepected discovery that panels combining one or more of these proteins and peptides can be utilized in methods of determining the probability for preeclampsia in a pregnant female with relatively high sensitivity and specificity. These proteins and peptides disclosed herein serve as biomarkers for classifying test samples, predicting a probability of preeclampsia, monitoring of progress of preeclampsia in a pregnant female, either individually or in a panel of biomarkers. | 2021-05-27 |
20210156871 | PEPTIDE ANALYZING METHOD - In the analysis method according to the present invention, a predetermined peptide is separated by immunoprecipitation using an antibody which specifically binds to either an N-terminus or a C-terminus of the predetermined peptide. The separated predetermined peptide is digested with a protease to prepare peptide fragments, and among the peptide fragments, a peptide fragment at a terminus opposite to a terminus binding to the antibody is mass-spectrometrically detected. | 2021-05-27 |
20210156872 | POLYSPECIFICITY REAGENTS, METHODS FOR THEIR PREPARATION AND USE - The present invention relates, inter alia, to polyspecificity reagents, methods of making the same, and methods of using the same in, inter alia, the selection, screening, enrichment, and identification of non-polyspecific, and thus developable, polypeptides. | 2021-05-27 |
20210156873 | METHODS AND COMPOSITIONS FOR ASSESSING ANTIBODY SPECIFICITIES - The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition. | 2021-05-27 |
20210156874 | METHODS FOR QUANTIFYING FRATAXIN ACTIVITY - The present disclosure provides methods, compositions and kits for measuring activity of a frataxin (FXN) protein, e.g., an FXN fusion protein. The present invention also provides methods for identifying compounds capable of modulating activity of an FXN protein, e.g., an FXN fusion protein. | 2021-05-27 |
20210156875 | CIRCULATING DKK3 (DICKKOPF-RELATED PROTEIN 3) IN THE ASSESSMENT OF ATRIAL FIBRILLATION - The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of DKK3 in a sample from the subject, and comparing the amount of DKK3 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to a method for diagnosing heart failure and/or at least one structural or functional abnormality of the heart associated with heart failure. | 2021-05-27 |
20210156876 | METHOD AND DEVICE FOR CONTROLLING DETECTION-COMPOSITION PREPARATION INSTRUMENT - Provided is a method and device for controlling a preparation instrument that prepares a detection composition used for detecting a target nucleic acid molecule in a specimen using an integrated instruction file. | 2021-05-27 |
20210156877 | RACK FOR AUTOMATED ANAYLZER - A rack for automated analyser systems and provides a rack for automated analyser systems, the rack comprising a main body having an extended front side and a corresponding extended reverse side as well as at least two side walls defining at least one opening that is accessible from the main body's upper side for taking up a container for a sample that is to be processed; an upper insert that is arranged onto an upper end of the main body, wherein the upper insert has openings with a predefined diameter defining the upper surface of the rack. | 2021-05-27 |
20210156878 | INTELLIGENT PRESSURE CONTROL APPARATUS AND METHODS FOR MAINTAINING MANIFOLD PRESSURE IN A DIAGNOSTIC TESTING APPARATUS - Apparatus configured to control chamber pressure during pipette rinsing having lower pressure recovery time. Pressure control apparatus includes pipettes to dispense liquid, a manifold chamber to supply liquid to the pipettes, a flow control valve in each flow path, a pump to supply the liquid, a pressure sensor to provide measured pressure, and a flow controller, which in a calibration mode, decreases a pump drive setting if measured pressure is high, increases the setting if measured pressure is low, and stores the pump drive setting for the individual combined operational state if the pressure is within predetermined pressure threshold limits, or in a testing mode, determines if the measured pressure is within the threshold limits for a previously-commanded state combination, and adjusts the pump drive setting if not within the threshold limits for a next time. Methods for operating pressure control apparatus are described, as are other aspects. | 2021-05-27 |
20210156879 | AUTOMATIC ANALYZER AND METHOD FOR CARRYING OUT CHEMICAL, BIOCHEMICAL AND/OR IMMUNOCHEMICAL ANALYSES - Aspects of the present disclosure relate to a method and/or a device for carrying out chemical, biochemical and/or immunochemical analyses of liquid samples, which are present in a sample store of an automatic analyzer, with the aid of liquid reagents which are present in at least one reagent store of the analyzer, with cuvettes for receiving the liquid samples and reagents, wherein a plurality of cuvettes is arranged as at least one stationary, linear cuvette array in the analyzer. The analyzer has movable and stationary automated components, wherein at least two automated components are designed so as to be movable in the x-direction independently of one another along or parallel to the line of movement defined by the linear cuvette array and each have access to different cuvettes or groups of cuvettes in a freely selectable sequence. | 2021-05-27 |
20210156880 | STRUCTURE OF SPEED SENSOR ARRANGEMENT OF VEHICLE - A structure of a speed sensor arrangement of a vehicle is provided. The vehicle includes a power unit. The power unit is connected with a transmission system. The transmission system is formed with a sensing space. The sensing space is provided therein with a speed sensor. As such, the speed sensor is arranged in a completely concealed space to prevent the speed sensor from being hit by external sand and stones or corroded by external dust or moisture. | 2021-05-27 |
20210156881 | DYNAMIC MACHINE VISION SENSOR (DMVS) THAT PERFORMS INTEGRATED 3D TRACKING - Provided are embodiments for a device and method for measuring three-dimensional ( | 2021-05-27 |
20210156882 | ACOUSTIC DETECTION OF STALL OVER A WING SURFACE - Apparatus and associated methods relate to detecting turbulence of an airstream over an airfoil surface of an aircraft using a sequence of acoustic transducers attached to the airfoil surface of the aircraft along a path. Each of the sequence of acoustic transducers is configured to detect acoustic waves indicative of airstream condition proximate the acoustic transducer. A processor is configured to determine, for each of the sequence of acoustic transducers, a level of turbulence of the airstream proximate the acoustic transducer. | 2021-05-27 |
20210156883 | Fluid Hose Splice Assembly - A fluid hose splice assembly for visually diagnosing fluid flowing through a fluid hose includes a tube that is spliceable into an existing fluid hose such that a fluid flows through the tube. The tube is comprised of a translucent material thereby facilitating the fluid to be visible through the tube for diagnostic observation of the fluid. The tube has a plurality of observation windows that are each integrated into the tube. Each of the observation windows is convexly arcuate with respect to the tube to enhance visibility of the fluid flowing through the tube. | 2021-05-27 |
20210156884 | PORTABLE ELECTROCHEMICAL MICROSCOPY DEVICE, KITS COMPRISING SAME AND USES THEREOF - The invention relates to the field of localized surface analysis, characterization and modification by electrochemistry. It particularly relates to a portable electrochemical microscopy device, to kits comprising such a portable device, and to uses of the portable device and kits. According to the invention, the portable device comprises: a body having a gripping surface for a user and a bearing surface that can be applied to a surface of a substrate to be analyzed; an electrolytic chamber formed in the body and arranged so as to receive an electrolyte, the electrolytic chamber comprising an opening leading to the bearing surface; and a working probe having a distal end arranged in the electrolytic chamber. | 2021-05-27 |
20210156885 | PROBE - A probe includes: a tubular barrel; a first plunger that has a proximal end portion inserted from one opening end of the barrel and slides along an axial direction of the barrel in a state in which a distal end is exposed; and a coil spring that is disposed inside the barrel and urges the first plunger in the axial direction of the barrel. The proximal end portion of the first plunger includes: an insertion portion that extends inside the coil spring from one end of the coil spring; and a head portion that is coupled to the insertion portion, has an outer diameter larger than an outer diameter of the coil spring, and abuts against the one end of the coil spring. | 2021-05-27 |
20210156886 | CONDUCTIVE TEST PROBE - A conductive probe may include a probe body for communicating with a circuit tester or a jumper. The probe body may be formed of metal and may have a free end. A probe tip may be mounted to the end of the probe body. The probe tip may be formed of thorium-tungsten. The probe tip may be configured for contacting a circuit node. | 2021-05-27 |
20210156887 | CONTACT PROBE AND PROBE UNIT - A contact probe includes: a cylindrical pipe member; a collar including a hollow portion and fixed to an inner circumferential side of at least one end in a longitudinal direction of the pipe member; and an inner conductor including a flange configured to abut on a stepped portion formed by the pipe member and the collar, the inner conductor being expandable and contractible along the longitudinal direction and penetrating the pipe member. | 2021-05-27 |
20210156888 | SHUNT RESISTOR FOR DETECTING THE STATUS OF AN ELECTRICAL ENERGY STORAGE UNIT - The invention relates to a shunt resistor ( | 2021-05-27 |
20210156889 | HIGH DENSITY WAVEGUIDE ASSEMBLY FOR MILLIMETER AND 5G APPLICATIONS - Embodiments of the present disclosure use a customizable ganged waveguide that comprises a top metal plate and a bottom metal plate with trenches that come together in a way so as to form waveguide channels. The waveguide assembly of the present invention also comprises a waveguide adapter affixed to a first end of the ganged waveguide and operable to conduct the signal to a tester. Further, it comprises an air barrier affixed to a second end of the ganged waveguide to prevent air from flowing from the ganged waveguide to a printed circuit board connected at the second end. Finally, it comprises a tuning plate comprising double ridge slots configured to allow maximal signal to be transferred to the printed circuit board from the ganged waveguide. | 2021-05-27 |
20210156890 | STAGE AND INSPECTION APPARATUS - A stage on which an inspection object having an electronic device is placed, the electronic device being pressed against a contact terminal of a probe card of an inspection apparatus by applying a load, includes: a first cooling plate including a first coolant flow path formed in the first cooling plate; a heating source mounted on the first cooling plate and configured to heat the inspection object; a transmission member installed on the heating source and transmits light output from the heating source; and a second cooling plate installed on the transmission member, including a placement surface configured to vacuum-suction the inspection object and a second coolant flow path, made of ceramic, and subjected to a mirror polishing process on the placement surface. | 2021-05-27 |
20210156891 | STAGE AND INSPECTION APPARATUS - A stage on which an inspection object having an electronic device against which a contact terminal of a probe card of an inspection apparatus is pressed by a load applied thereto is placed, includes a first cooling plate including a first coolant flow path formed therein, a heating source mounted on the first cooling plate and including a plurality of light emitting elements so as to heat the inspection object, a transparent member provided on the heating source and transmitting light output from the heating source, a second cooling plate provided on the transparent member so as to hold the inspection object and including a second coolant flow path formed therein, and a transparent resin layer filled between the first cooling plate and the transparent member so as to cover the heating source. | 2021-05-27 |
20210156892 | Portable Device for a Contactless Current Measurement Using Induced Magnetic Fields - Portable device for a contactless measurement of a current passing through an electrical conductor, the device including a measuring module and a processing module, the measuring module, configured to be held by an operator in contact with the conductor in a plane substantially orthogonal to this conductor and without clamping this conductor, including one or two pluralities of magnetic field sensors, and the processing module being configured to perform a determined linear combination of the plurality of signals delivered by one or the two pluralities of magnetic field sensors, so as to perform an angular spatial filtering isolating the current to be measured from other disturbing currents passing through other conductors. | 2021-05-27 |
20210156893 | ARC DETECTOR FOR DETECTING ARCS, PLASMA SYSTEM AND METHOD OF DETECTING ARCS - An arc detector for detecting arcs in an RF plasma system includes at least two inputs configured to connect to an RF source, at least one output configured to connect to a plasma load, and a 3 dB coupler connected to the at least two inputs and the at least one output. The arc detector further includes a measuring device configured to measure at least two physical quantities transmitted between the 3 dB coupler and the at least one output, a determinator configured to determine an evaluation quantity based on the at least two physical quantities, and a differentiator configured to differentiate the evaluation quantity. The arc detector additionally includes a comparator configured to compare the output quantity of the differentiator with a reference value indicative of an arc. | 2021-05-27 |
20210156894 | HIGH-SPEED AFE FOR CURRENT MONITORING APPLICATIONS - A current monitoring circuit includes: an output terminal configured to be coupled to a controller; an inverter having an output coupled to the output terminal; a first transconductance amplifier having first and second inputs configured to be coupled across a sense resistive element, and an output coupled to an input of the inverter; and a current generator having a second transconductance amplifier configured to generate a reference current at an output of the current generator based on a reference voltage, the output of the current generator being coupled to the input of the inverter, where the output of the inverter is configured to be in a first state when a load current flowing through the sense resistive element is higher than a predetermined threshold, and in a second state when the load current is lower than the predetermined threshold, and where the predetermined threshold is based on the reference current. | 2021-05-27 |
20210156895 | MULTI-DEVICE CURRENT MEASUREMENT CROSSTALK COMPENSATION - A measurement module receives crosstalk compensation factors that include distance factors based on respective distances of a current sensor of the module from respective current sensors of other measurement modules and phase difference factors based on respective differences between the phase of a source current measured by the module and respective phases of source currents measured by the other modules. The module monitors messages reporting current measurements transmitted from the other modules connected to a broadcast bus, of current measurements made by respective current sensors of the other modules measuring other respective source currents. The module determines a reported current that is computed as a function of current measurement by the module's current sensor, reported current measurements monitored from the other modules, and the received crosstalk compensation factors. The module transmits the determined reported current over the broadcast bus to the other modules and a central controller. | 2021-05-27 |
20210156896 | CIRCUIT ARRANGEMENT AND METHOD FOR DETERMINING A RESISTANCE CHANGE AND METHODS FOR DETERMINING LEAD RESISTANCES - In a circuit arrangement for determining a resistance change, a measuring resistor can be connected by first and second supply leads and first and second sensor leads in a four-wire arrangement, such that the first supply lead and the measuring resistor form a first resistor of a first voltage divider, and the second supply lead and a supplementary resistor form a second resistor of the first voltage divider. The circuit arrangement has a second voltage divider with third and fourth resistors. The first and second voltage dividers form a Wheatstone bridge. The circuit arrangement is configured to apply a supply voltage across the Wheatstone bridge, to determine first and second supply voltage drops across the first and second supply leads, and to determine an ascertainment voltage in proportion to a reference voltage. The ascertainment voltage depends on a bridge voltage applied between the first and second voltage dividers. | 2021-05-27 |
20210156897 | NOISE-INDEPENDENT LOSS CHARACTERIZATION OF NETWORKS - An S-parameter of a reference impedance is determined and converted to a desired mode of operation. Example modes of operation include a single-ended input output mode, a differential input output mode, and a common input output mode. The complex values of the impedance at each port as a function of frequency can be computed using the novel closed-form quadratic S-parameter equation which utilizes the concept of matched networks by setting the reflections and re-reflections to zero through S-parameter renormalization. Using the S-parameter renormalization, the insertion loss corresponding to zero reflections and re-reflections is calculated. Based on the determination of the matching impedance used to reduce the reflections and re-reflections to zero, a parameter of a circuit comprising the network may be modified to reduce noise. | 2021-05-27 |
20210156898 | Photonic-Crystal Vapor Cells for Imaging of Electromagnetic Fields - In a general aspect, vapor cells are disclosed that include a dielectric body having a first surface and a second surface. The dielectric body includes a plurality of cavities extending from the first surface to the second surface and ordered periodically to define a photonic crystal structure in the dielectric body. Each cavity has a first opening defined by the first surface and a second opening defined by the second surface. The photonic crystal structure has a photonic band gap. The vapor cells additionally include a first optical window covering the first openings and having a surface bonded to the first surface of the dielectric body to form a seal around each of the first openings. A second optical window covers the second openings and has a surface bonded to the second surface of the dielectric body to form a seal around each of the second openings. | 2021-05-27 |
20210156899 | Method for fault location to multi-terminal traveling wave in direct current distribution line - A method for fault location to multi-terminal traveling wave in a direct current distribution line, which belongs to the field of power line fault ranging and location technology. The method includes a main site and a plurality of acquisition points installed into the distribution line and includes steps as follows. Step | 2021-05-27 |
20210156900 | Method for fault location to single-terminal traveling wave - A method for fault location to single-terminal traveling wave includes steps as follows. Step (a): recording a waveform of a traveling wave signal of disturbance by a traveling wave device when a line disturbance occurs. Step (b): performing a phase mode transformation on the waveform recorded by the step (a), so as to obtain components of line mode and zero mode of a fault initial traveling wave, and performing a wavelet transform to decompose the components of the line mode to obtain singularities in the waveform of the traveling wave. Step (c): calculating a wavefront slope k of the components of the line mode of the fault initial traveling wave. Step (d): computing a preliminary fault distance D according to the slope k computed in the step (c). Step (e): confirming a fault point according to the preliminary fault distance and wavelet singularities of the components of the line mode. Step (f): end. | 2021-05-27 |
20210156901 | PROBER - An object of the present invention is to provide a prober that is able to carry out accurate inspection of semiconductor device in wafer state by reducing the effect of the external noises and the leakage of current and further by eliminating the stray capacitance of the chuck stage against the prober housing. The present invention attains this object by providing a prober comprising a chuck cover conductor that comprises a bottom conductor and a side conductor and an open top, wherein a chuck stage can be contained within a space surrounded by the bottom conductor and the side conductor; an upper cover conductor which has opening through which the conducting support members of the probe for front-side electrodes and the probe for back-side electrodes can be passed, and which is large enough to cover, in a plane view, at least the open top of the chuck cover conductor when the contact member of the probe for front-side electrodes moves relatively within a wafer under inspection; and, a conducting means that brings the chuck cover conductor and the upper cover conductor into contact and makes them electrically continuous. | 2021-05-27 |
20210156902 | SEMICONDUCTOR CHIP AND CIRCUIT AND METHOD FOR ELECTRICALLY TESTING SEMICONDUCTOR CHIP - A semiconductor chip and a circuit and a method for electrically testing a semiconductor chip are disclosed, which pertain to the field of semiconductor technology. The semiconductor chip includes: a first electrical connection point, configured to connect a first pole of a force power supply in a Kelvin testing circuit; and a second electrical connection point, configured to connect a first terminal of a detecting device in the Kelvin testing circuit, wherein the first electrical connection point and the second electrical connection point are connected with each other within the semiconductor chip, and the first pole of the force power supply and the first terminal of the detecting device are arranged on the same side of the Kelvin testing circuit. According to the present disclosure, the semiconductor chip can be electrically tested with an enhanced accuracy and no impact from external contact and conduction resistances. | 2021-05-27 |
20210156903 | PROBING APPARATUS EQUIPPED WITH HEATING DEVICE FOR LIGHT EMITTING CHIP - A probing apparatus includes a carrier having an opening, a supporter disposed on the carrier in a way that its bottom surface faces toward the carrier, its top surface for disposition of a wafer, and its light permeable portion allowing light to pass through the top and bottom surfaces corresponding in position to the opening, an air heating device having a covering plate and an air supply unit, and a probing device having a probe protruding out of the bottom surface of the air heating device. A thermal air source provides thermal air to a heating space between the bottom surface of the air heating device and the top surface of the supporter through an air supply passage of the air supply unit. The probing apparatus can test light emitting efficiency of a light emitting chip in the wafer and heat the chip at the same time. | 2021-05-27 |
20210156904 | SEMICONDUCTOR TEST DEVICE AND SYSTEM AND TEST METHOD USING THE SAME - A test method for a semiconductor device includes determining a contact failure between a first semiconductor chip and a second semiconductor chip during assembly of a semiconductor package including the first semiconductor chip and the second semiconductor chip, using a test circuit embedded in the first semiconductor chip, and after the assembly of the semiconductor package, determining whether the semiconductor package is defective by using the test circuit. | 2021-05-27 |
20210156905 | METHOD AND APPARATUS FOR CONTROLLING TESTER, MEDIUM AND ELECTRONIC DEVICE - A method and apparatus for controlling a tester, related medium and electronic device are provided. The apparatus includes a vibration data collector attached on a side wall of the tester to collect vibration data from the tester during operation thereof. The method includes: receiving the vibration data collected by the vibration data collector; comparing the vibration data with a predetermined threshold to generate a comparison result; and controlling an operating state of the tester based on the comparison result. This method may timely identify any instability of the tester and prompt for repair if necessary. It substantially reduces the time and material costs associated with a test, and thus reduces the non-chip-attributable defect rate. | 2021-05-27 |
20210156906 | SEMICONDUCTOR TEST SOCKET WITH A FLOATING PLATE AND LATCH FOR HOLDING THE SEMICONDUCTOR DEVICE - A test socket assembly for a semiconductor device used for burn-in testing comprising a base assembly, a floating plate coupled to the base assembly, and a latch assembly mounted on the floating plate for the retention and movement of the semiconductor device. The base assembly further includes a pin assembly for electrically coupling to the semiconductor device for burn-in testing and at least two upstanding flex arms. In addition, the floating plate and the latch assembly move to a test position for accommodating a varying height of the semiconductor device when mating with a test fixture while the latch still effectively retains the semiconductor device. Lastly, the floating plate is held in a fixed load position due to the support provided by the upstanding flex arms when inserting the semiconductor device into the test socket. | 2021-05-27 |
20210156907 | OPTICAL TEST EQUIPMENT WITH HEATING FUNCTION - An optical test equipment includes a chuck, a light receiving device corresponding in position to an opening of the chuck, a transparent heating plate disposed on the chuck or light receiving device in a way that the bottom surface of the transparent heating plate faces toward the light receiving device for a wafer to be disposed on the top surface of the transparent heating plate, allowing light to pass through the top and bottom surfaces and being powered to generate heat to heat the wafer, and a probing device including a seat and a probe protruding from the seat toward the top surface of the transparent heating plate for probing a light emitting chip of the wafer. The equipment can perform light emitting efficiency test to the light emitting chip on the wafer before dicing and heat the light emitting chip at the same time. | 2021-05-27 |
20210156908 | THROUGH-SILICON VIA (TSV) FAULT-TOLERANT CIRCUIT, METHOD FOR TSV FAULT-TOLERANCE AND INTEGRATED CIRCUIT (IC) - An integrated circuit with a through-silicon via (TSV) fault-tolerant circuit, a TSV fault tolerance method are disclosed. The IC may include a plurality of operational TSVs, a spare TSV, a plurality of fault-tolerance control modules each coupled to one of the plurality of operational TSVs and the spare TSV, and a decoder coupled to the fault-tolerance control modules. The fault-tolerance control modules may be configured to deactivate an operational TSV that is determined to be defective and activate the spare TSV based on a positioning code for the defective operational TSV from the decoder. The IC may reduce the defect rate in the fabrication of TSV-based three-dimensional (3D) IC chips. | 2021-05-27 |
20210156909 | ELECTRONIC COMPONENT HANDLER AND ELECTRONIC COMPONENT TESTER - An electronic component handler includes a first holder that is movable in a first direction and a second direction different from the first direction and is capable of holding an electronic component, a second holder that is movable in the first direction and the second direction independently of the first holder and is capable of holding the electronic component, a light irradiation section that is arranged so as to be capable of irradiating an electronic component placement portion on which the electronic component is placed with light through a gap between the first holder and the second holder, and an imaging section that is capable of imaging the electronic component placement portion irradiated with the light in the first direction, and determines whether or not the electronic component is placed on the electronic component placement portion based on the imaging result obtained by imaging by the imaging section. | 2021-05-27 |
20210156910 | DYNAMIC WEIGHT SELECTION PROCESS FOR LOGIC BUILT-IN SELF TEST - A series of pseudo-random test patterns provide inputs to a logic circuit for performing logic built-in self test (LBIST). A weight configuration module applies one or more weight sets to the pseudo-random test patterns, to generate a series of weighted pseudo-random test patterns. A logic analyzer determines a probability expression for each given net of the logic circuit, based on associated weight sets and a logic function performed by the net. A probability module computes an output probability for each net based on associated probability expressions and associated input probabilities. The weight configuration module optimizes the weight sets, based on the computed net probabilities, and further based on a target probability range bounded by lower and upper cutoff probabilities. | 2021-05-27 |
20210156911 | LOGIC BUILT-IN SELF TEST DYNAMIC WEIGHT SELECTION METHOD - An approach for testing, including a self-test method, a semiconductor chip is disclosed. The approach generates test patterns, including weighted random test patterns, for testing random pattern resistant faults, and un-modeled faults directed at specific logic groups, where the dynamically generated test pattern weights are configured to optimize test coverage and test time. The dynamically generated test patterns are based on factors related to random pattern resistant logic structures interconnected via scan chains. More particularly, the dynamically generated test patterns are designed to enable fault detection within logic structures that are resistant to fault detection when tested with random patterns. | 2021-05-27 |
20210156912 | Method For Boundary Scan Inspection And Functional Circuit Test Of Motherboard And Device Using The Same - A method and a device for a boundary scan inspection and a functional circuit test of a motherboard are disclosed. The method is applicable to a machine and includes steps of connecting a BSI fixture, a functional circuit test fixture and a hard drive to the motherboard, and making a host computer and the motherboard in communication connection with each other; performing, by the host computer, the boundary scan inspection on the motherboard based on the BSI fixture; performing, by a function test system installed in the hard drive, the functional circuit test on the motherboard based on the functional circuit test fixture. The boundary scan inspection and the functional circuit test can be integrated in the same machine, so as to facilitating to perform the boundary scan inspection and the functional circuit test on the motherboard, thereby speeding up test speed and reducing the number of the machines. | 2021-05-27 |
20210156913 | BOUNDARY TEST CIRCUIT, MEMORY AND BOUNDARY TEST METHOD - Boundary test circuit, memory and boundary test method are provided. The boundary test circuit may include a plurality of serially-connected wrapper boundary registers (WBRs) and a plurality of toggle circuits (TCs). Each WBR may include a first I/O for receiving an initial test signal and a second I/O for transmitting the initial test signal to the WBR at a succeeding stage. Each TC may include an input for receiving the initial test signal stored in a corresponding WBR, a control I/O for receiving a toggle signal, and an output for transmitting a real-time test signal to the integrated circuit. The toggle signal may be configured to control phase switching of the real-time test signal, and, depending on the toggle signal, the real-time test signal may have a phase identical or inverse to a phase of the initial test signal. This method improves the efficiency and flexibility of the boundary test. | 2021-05-27 |
20210156914 | TEST METHOD AND TEST SYSTEM - The present invention provides a method, device, and system for testing devices under testing (DUTs). The method comprises: sending a scan activated signal and a synchronous clock signal via the second signal line, and sending a first preset signal via the serial signal line, wherein each bit of the first preset signal is transmitted to a corresponding scan chain unit in a sequence of serial connection of the plurality of scan chain units with according to the synchronous clock signal, the corresponding scan chain unit is one of the plurality of scan chain units connected serially and coupled to the plurality of DUTs via a third signal line; sending a scan deactivated signal via the second signal line, to deactivate the scan chain units from identifying and receiving the first preset signal; and sending a second preset signal via the second signal line, and sending a test signal via the first signal line. | 2021-05-27 |
20210156915 | SIGNAL ANALYSIS METHOD AND MEASUREMENT INSTRUMENT - A signal analysis method is disclosed. The method comprises the following steps: An input signal comprising a symbol sequence is received, wherein the input signal is associated with a first clock signal comprising at least one jitter component. A second clock signal is recovered based on said input signal. At least one jitter parameter is determined that is associated with said at least one jitter component. A jitter signal is reconstructed based on said at least one jitter parameter, wherein said jitter signal is associated with said at least one jitter component. A third clock signal is determined based on said second clock signal and said jitter signal. Further, a measurement instrument is disclosed. | 2021-05-27 |
20210156916 | TESTING DEVICE AND TESTING METHOD - A testing device includes a transmitter circuit, a receiver circuit, and a loopback circuit. The transmitter circuit is configured to receive a plurality of first test signals. The receiver circuit is configured to receive input data from a plurality of pads in a normal mode. The loopback circuit is coupled to the plurality of pads and input terminals of a sampler circuit, and the loopback circuit is configured to transmit the plurality of first test signals from the transmitter circuit to the input terminals of the sampler circuit, in order to generate test data for subsequent analysis. | 2021-05-27 |
20210156917 | SIGNAL SKEW MEASUREMENT METHOD, APPARATUS, MEDIUM, AND ELECTRONIC DEVICE - The present invention discloses a signal skew measurement method for integrated circuit, a medium, and an electronic device. The method comprises: by a test machine, acquiring a first signal and a second signal output by an IC, respectively performing under-sampling on the first and second signals to obtain a first sampled signal and a second sampled signal; respectively performing digital conversion on the first and second sampled signals based on a preset threshold voltage to obtain a first digital signal and a second digital signal; respectively performing convolution on the first and second digital signals using a preset pulse signal to obtain a first comparison signal and a second comparison signal; and calculating a skew between the first and second comparison signals to obtain a reference skew, and determining a skew between the first and second signals according to the reference skew. | 2021-05-27 |
20210156918 | Trajectory-Optimized Test Pattern Generation for Built-In Self-Test - A circuit comprises: a bit-flipping signal generation device comprising a storage device and configured to generate a bit-flipping signal based on bit-flipping location information, the storage device configured to store the bit-flipping location information for a first number of bits, the bit-flipping location information obtained through a fault simulation process; a pseudo random test pattern generator configured to generate test patterns based on the bit-flipping signal, the pseudo random test pattern generator comprising a register configured to be a linear finite state machine, the register comprising storage elements and bit-flipping devices, each of the bit-flipping devices coupled to one of the storage elements; and scan chains configured to receive the test patterns, wherein the bit-flipping signal causes one of the bit-flipping devices to invert a bit of the register each time a second number of test patterns is being generated by the pseudo random test pattern generator during a test. | 2021-05-27 |
20210156919 | DYNAMIC SECURITY PROTECTION IN CONFIGURABLE ANALOG SIGNAL CHAINS - A system and method for dynamically protecting against security vulnerabilities in a reconfigurable signal chain. The system includes a signal chain formed from at least a first component connected with a second component. The first component has a set of source outputs and a first authentication block, and the second signal chain component has a set of destination inputs and a second authentication block. The system also includes a signal chain configurator that populates the first authentication block with at least one validated endpoint from the set of destination inputs. A signal chain integrity block, which is communicatively coupled with the first authentication block and the second authentication block, identifies a source-destination pair from one or more endpoint pairs formed from the at least one validated endpoint and the set of source outputs. The signal chain integrity block propagates the source-destination pair to the first authentication block and the second authentication block. The second authentication block authenticates any received input using the source-destination pair. | 2021-05-27 |
20210156920 | Electrical Installation Measuring System - It is described an electrical installation measuring system comprising a control and measuring device configured to be installed on an electrical panel of an electrical installation and perform at least one measure of an electrical parameter of the electrical installation depending on an electrical load connected to the electrical installation and transmit command signals along a telecommunication link. The system further comprises a variable load device connectable to the electrical installation and configured to: receive the command signals from the telecommunication link; and assume a plurality of load configurations according to the command signals. | 2021-05-27 |
20210156921 | BATTERY STATE DETERMINATION SYSTEM AND BATTERY STATE DETERMINATION METHOD - A battery state determination system is a battery state determination system including an in-vehicle device and a server device, the in-vehicle device includes an acquisition part acquires physical quantity data showing a physical quantity related to a state of a battery mounted in a vehicle, an observation part that observes a feature related to a state change of the battery on the basis of the physical quantity data at a plurality of different observation times, and a transmission part that transmits a plurality of pieces of feature data which expresses the feature observed each observation time to the server device, and the server device includes a reception part that receives the plurality of pieces of feature data transmitted from the in-vehicle device, and a diagnosis part that diagnoses a deterioration state of the battery on the basis of the plurality of pieces of feature data. | 2021-05-27 |
20210156922 | METHOD FOR DETERMINING DISPERSIBILITY OF ELECTRODE MATERIAL LAYER - The present invention discloses a method for determining dispersibility, comprising (a) selecting two random points ( | 2021-05-27 |