22nd week of 2009 patent applcation highlights part 38 |
Patent application number | Title | Published |
20090136885 | APPARATUS FOR TOASTING A WINE BARREL - A platform has an opening therein. The platform is adapted to receive a heat source therein. The platform is rotatably disposed about the heat source. A motor is operatively coupled to the platform for rotating the platform about the heat source. A temperature sensor senses the temperature at a predetermined position on the interior surface of a barrel disposed on said platform and provides a temperature output. A central processing unit has a clock for measuring an interval during which a barrel is exposed to the heat source. A database stores toasting recipes, which are a function of time and temperature. The central processing unit receives an input from the sensor and clock and utilizes the recipe stored in the database to provide an output to an alarm if the sensed temperature during the input time interval does not substantially correspond the recipe as stored in the database. | 2009-05-28 |
20090136886 | Method and Device for Removing Volatile Organic Components From Waste Gases of a Clinker Installation - In a method for removing volatile organic components (VOC) from waste gases of a cement clinker kilns installation, in which the largely cooled waste gases are subjected to post-combustion, a post-combustion is carried out to an extent as to ensure a reduction of the concentration of the VOC below the admissible threshold values. The post-combustion is carried out for the production of vapour, whereby the production of vapour in the post-combustion is dimensioned for a gas volume to be post-combusted, ensuring that a partial quantity of the waste gas corresponding to the gas volume allows for the reduction of emitted VOC per unit time in the waste gas below admissible concentration values by rarefaction and whereby this partial quantity is simultaneously dimensioned for the production of a amount of vapour sufficient for the economical operation of a given steam turbine. The device for carrying out said method is characterized in that a branch line is connected to the waste gas line of the cement clinker kiln installation, between the pre-calciner and the waste gas suction fan, to which branch line a combustion chamber for a heat exchanger for the production of vapour and a steam turbine are connected. The invention also relates to a device for carrying out said method, characterised in that a branch line is connected to the waste gas line of the clinker installation, between a preheater and the waste gas suction fan, a combustion chamber for a heat exchanger for producing water vapour and a steam turbine being connected to said branch line. | 2009-05-28 |
20090136887 | ROTARY HEARTH FURNACE - PROBLEM TO BE SOLVED: To provide a rotary hearth furnace which has a simple furnace structure in which the furnace is not damaged even if the furnace is operated for a long term while presenting general equations capable of adequately determining a thermal expansion margin in the rotary hearth furnace. | 2009-05-28 |
20090136888 | Heat processing apparatus - The present invention is a heat processing apparatus comprising: a processing vessel that receives a plurality of objects to be processed in a tier-like manner to subject the objects to be processed to a predetermined heating process; a tubular heater disposed to surround the processing vessel, the tubular heater being capable of heating the objects to be processed; an exhaust heat system for discharging an atmosphere in a space between the heater and the processing vessel; and a cooling unit that blows-out a cooling fluid into the space to cool the processing vessel. The heater has a tubular heat insulating member, and a heating resistor arranged on an inner circumference of the heat insulating member. The cooling unit has a plurality of blowing nozzles embedded in the heat insulating member. Each of the blowing nozzles is formed in such a manner that an inlet orifice of the blowing nozzle and an outlet orifice thereof are not linearly aligned to each other. | 2009-05-28 |
20090136889 | ORTHODONTIC BRACKET INCLUDING MECHANISM FOR REDUCING SLOT WIDTH FOR EARLY TORQUE CONTROL - Orthodontic brackets include a bracket base, at least one arch wire slot formed in the base adapted to receive and arch wire therein, and means for selectively narrowing the width of at least a portion of the arch wire slot so as to allow for engagement of an undersized arch wire having a width less than the slot width. The means for selectively narrowing the width of the arch wire slot may comprise one or more spaced apart cuts disposed in at least one side wall defining the arch wire slot so as to define a bendable portion of the sidewall. | 2009-05-28 |
20090136890 | BRACKET FOR REVISING A SET OF TEETH, BRACKET POSITIONING JIG, SYSTEM FOR REVISING A SET OF TEETH USING THE SAME, AND METHOD OF MAKING THE JIG - A system for revising a set of teeth including a bracket for revising a set of teeth and a bracket positioning jig is provided. The bracket positioning jig includes a cap at the lower portion of which a groove contacting tooth is formed, and which has a throughhole to lengthy direction on the upper portion of a cap body, and a connector one side of which has a fixed protrusion which is detachably inserted into and fixed to the throughhole of the cap, and the other side of which is bent toward the lower end of the body and has a coupler which is combined on a slot of an orthodontics treatment bracket for revising a set of teeth. An individual prescription value which is the most appropriate for an individual patient is given to the bracket positioning jig on a computer program to thus manufacture a desired jig, so that a non-prescription bracket as well as a bracket having a given prescription value can be used. | 2009-05-28 |
20090136891 | ORTHODONTIC APPLIANCE - Disclosed herein relates to an orthodontic appliance, in particular to an orthodontic appliance connected to a tooth and coacting with an archwire. The orthodontic appliance has at least one archwire slot extending through mesiodistally. At least one sub-slot opening to the archwire slot is provided in the sidewalls of the archwire slot. The above-mentioned configurations facilitate the movement of the tooth mesiodistally. With different archwires and different ligation manners, the position of the archwire in the archwire slot can be controlled, thus it is easy to tip teeth mesiodistally and to upright the teeth mesiodistally with small force. The orthodontic appliance has simple structure, and with which it is not necessary to employ extraoral force and mini-implant to strengthen the anchorage. | 2009-05-28 |
20090136892 | Measuring Apparatus For The Programming And Welding Of Adjustable Brackets - This invention refers to a MEASURING APPARATUS FOR THE PROGRAMMING AND WELDING OF ADJUSTABLE BRACKETS permitting the electrical spot welding with a great accuracy of the elements of an adjustable bracket, in this manner being able to adjust or to program the information that the orthodontist wants to incorporate in the bracket in regard to inclination, angulation and rotation. In order to achieve this aim I developed two attachments: THE POSITION MEASURING ACCESSORY and the WELDING ACCESSORY. | 2009-05-28 |
20090136893 | Oral appliance for delivering a medicament - An oral appliance is provided for delivering a medicament to at least a portion of teeth and/or soft tissue areas inside a mouth, the oral appliance comprising an interior surface having a porous material disposed on at least a portion of the interior surface of the oral appliance, the porous material containing a medicament and the interior surface being formed to fit contours of at least the portion of the teeth and/or soft tissue areas inside the mouth and being capable of supporting and holding the porous material in contact with at least the portion of the teeth and/or soft tissue areas inside the mouth to deliver the medicament. | 2009-05-28 |
20090136894 | Insert For A Handheld Ultrasound Surgical Device - An insert for a handheld ultrasound surgical device is disclosed. The insert comprises an interface to receive ultrasound vibrations and provide fluid to a channel within the insert. The insert also comprises a tip having a plurality of cutting elements disposed in a substantially circular configuration. Each of the cutting elements is disposed radially from the opening to provide a plurality of corridors that allows that fluid to pass from the opening to an edge of the tip. | 2009-05-28 |
20090136895 | Evacuation Tips having Lateral Vents - Disclosed is an evacuation tip that is adapted to be used with an evacuation apparatus for collecting the debris and fluids during dental procedures. The evacuation tip comprises a cylindrical body. The evacuation tip has a first end portion and a second end portion. The first end portion comprises at least one vent on a lateral surface of the evacuation tip and a cutout on the first end portion. The at least one vent is configured to suck the oral debris and fluids during the dental procedures. Further, the second end portion is connected to the evacuation apparatus. The evacuation tip is configured to transfer the oral debris and the fluids collected through the at least one vent from the first end portion to the evacuation apparatus connected to the second end portion. | 2009-05-28 |
20090136896 | DENTAL APPARATUS FOR SHAPING AND CLEANING A ROOT CANAL - Apparatus is disclosed for use in cleaning dental root canals using an endodontic file. The file is mounted in a drill head driven by an electric motor. The motor is normally driven in one, forward direction, but periodically, the motor rotation is reversed for a very short time. The duration of the motor reversal is so short that although the motor rotates in the reverse direction, the inertia and backlash in the transmission between the motor output shaft and the drill head is such that the direction of rotation of the file in the root canal is not changed. | 2009-05-28 |
20090136897 | DENTAL INSTRUMENT AND METHOD OF USE - A dental instrument ( | 2009-05-28 |
20090136898 | Tap Drill for Dental Implant - A tap drill for dental implant for forming a space for coupling a fixture of the implant in an alveolar bone, includes: a shank part coupled with a torque transferring mechanism; and a tap part connected with the shank part, the tap part having: a tapping screw thread formed on the outer peripheral surface thereof for forming a space to insert and fix a fixture of the dental implant thereto; and cutting blades radially formed from the center of a front end face thereof, which is perpendicular to a rotary axis of the tap drill, whereby the tap drill can simultaneously perform a tapping work, on the outer peripheral surface of the tap part, against a cartilaginous tissue or an alveolar bone of a patient's body, and a cutting work on the front end face of the tap part while the tap part is rotated by the torque transferring mechanism. | 2009-05-28 |
20090136899 | DENTAL IMPLANT SYSTEM - An implant comprising two internal anti-rotational features. One anti-rotational feature is adapted to engage a driving tools while the other anti-rotational feature is adapted to engage an abutment. An implant abutment system is provided with an angled abutment adapted to mate with one of the anti-rotational features. A second, straight abutment is adapted to engage with the other anti-rotational feature. An abutment is provided with resilient fingers to interface with the implant and provide tactile and audible feedback indicating when the abutment is properly seated. An abutment screw extends through the abutment and engages the implant bore distal of the stem of the abutment. The abutment screw limits axial movement of the abutment relative to the implant. A driving tool comprising one of at least retention structure and visual alignment indicia is provided to facilitate screwing the implant into a patient's bone. | 2009-05-28 |
20090136900 | Muffle for the production of dental prostheses | 2009-05-28 |
20090136901 | Method and System for Preparing Dental Restorations - The present invention relates to a method and a system for preparing dental restorations from ceramic or polymeric material to achieve color and opacity gradients simulating natural dentition, wherein an ingot of ceramic or polymeric material is entirely or partially forced through a system of channels in a press mold into a mold cavity in the press mold, wherein the mold cavity corresponds to a dental restoration. | 2009-05-28 |
20090136902 | BLANK AS A DRILLING TEMPLATE AND FOR RECORDING DATA SETS - Process for defining a common reference system between, on the one hand, a set of image data, which show the jaw ( | 2009-05-28 |
20090136903 | PORTABLE ATV/ DIRT BIKE/ SNOWMOBILE SAFETY TRAINER AND METHOD FOR USE - Disclosed is a portable safety trainer that can be totally controlled by an instructor and provides safety training in operating an ATV, a dirt bike or a snowmobile. The trainer uses an actual ATV, dirt bike or snowmobile as part of a course in basic safety. In one embodiment, the trainer is used in conjunction with a movie player and a screen to show students real-life examples of driving an ATV, dirt bike or snowmobile without endangering the safety of the students being trained. | 2009-05-28 |
20090136904 | Device, system and game to plan meals and snacks - A device to plan meals, comprising, at least one Food Item Piece corresponding to an item of food, at least one Food Item Storage Page adapted to temporarily store the at least one Food Item Piece and at least one Daily Meal Planning Chart adapted to temporarily store the at least one Food Item Piece, wherein an individual may plan a meal by selecting at least one Food Item Piece corresponding to an item of food from the at least one Food Item Storage Page and temporarily store it on the at least one Daily Meal Planning Chart. | 2009-05-28 |
20090136905 | PERSONALIZEABLE GAMING SYSTEM - Game and gaming system which can be individualized and accessorized according to the user's desires. The system can be educational and instructive. The systems include a game board member and a plurality of pin members. The game board member is made of an elastomeric material and has a plurality of openings therein for receipt of pin members. The pin members are held in place by the elastomeric material. | 2009-05-28 |
20090136906 | Backlit map with interchangeable pictures - This invention is directed toward a map overlaying a lighted display box. The map has a plurality of magnified eye holes though which a person can view lighted, magnified pictures or photographs. The map can be easily opened such that the pictures can be interchanged, such that a user may begin with a map containing generic, stock photos of various national parks, surf spots, or baseball stadiums, then, over time, as the user physically visits these locations he/she can replace the stock photos with personalized photos. The color of light can be changed as well once a location is visited, to give the user a sense of visual association and accomplishment. | 2009-05-28 |
20090136907 | R.O.C. Syllable System - An English syllable system which uses English words, Partial English Words, and Phonics to teach people how to speak other languages with the accent as if the student were from that country. This system uses the preceding three types of words from the English Language to teach foreign languages. | 2009-05-28 |
20090136908 | MATHEMATICS TEACHING METHOD - A method for teaching mathematics that includes presenting one or more mnemonic tools that are non-arbitrarily associated with a module or “chunk” of information that covers a particular mathematics concept. | 2009-05-28 |
20090136909 | INTERPERSONAL RELATIONSHIP EVALUATION DEVICE, INTERPERSONAL RELATIONSHIP EVALUATION METHOD, INTERPERSONAL RELATIONSHIP EVALUATION SYSTEM, AND TERMINAL DEVICE - An interpersonal relationship evaluation method includes the steps of: obtaining position information obtained at each of the two or more terminal devices over a plurality of points in time; and calculating a mean value of distance between the respective terminal devices with a point in time as a target wherein a predetermined condition holds to obtain the mean value as an interpersonal relationship evaluation value regarding each terminal device user. | 2009-05-28 |
20090136910 | MEMORIZATION AID - A teaching system including a database including multiple question/answer sets, wherein substantially each question/answer set includes a question and at least one correct answer, and wherein at least two sets are adapted to test substantially a same data item; and a presentation module adapted to present to a user a second question/answer set relating to a first data item immediately following or subsequent to the user correctly responding to a first question/answer set relating to the first data item, and said presentation module further adapted to stop presenting question/answer sets related to the first data item once the user has responded correctly to two question/answer sets relating to the first data item without incorrectly responding to a question/answer set related to the first data item. | 2009-05-28 |
20090136911 | Interactive Guide Toy Vehicle Apparatus - A guide toy vehicle is used for obtaining related knowledge of exhibit in a pleasant and interactive way. Guidance materials are transferred between different guidance systems through a wireless network. Thus, a user can have a wide, easy and effective learning. | 2009-05-28 |
20090136912 | CARRIER FOR CELL CULTURE - A carrier for cell culture is provided which improves the cell proliferativity in serum-free culture and which is free from risk from infection factor contamination. The gist of the features of the present invention is to be formed of a crosslinked poly (meth) acrylic acid (salt) particle (A) and an artificial polypeptide (P) having at least one cell-adhesive minimal amino acid sequence (X) in one molecule and to have a water retention value of from 2 to 50 g/g. The (A) is preferably a particle produced by reversed phase suspension polymerization of an aqueous monomer solution containing (meth)acrylic acid and/or an alkali metal salt of (meth)acrylic acid. The (P) preferably has at least one auxiliary amino acid sequence (Y) in one molecule of the (P). The (X) is preferably an Arg Gly Asp sequence. | 2009-05-28 |
20090136913 | Gravity-Assisted Mixing Methods - A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle. | 2009-05-28 |
20090136914 | Identification and use of genes encoding holins and holin-like proteins in plants for the control of microbes and pests - This invention provides: 1) methods for the identification of broad-spectrum holins with a high level of nonenzymatic activity in membranes; 2) conditions required for maintaining and increasing the anti-microbial and anti-pest efficacy of holins in gene fusions; 3) a method for effective targeting of holins expressed in plants through use of a leader peptide to direct the holin protein to the plant apoplast and xylem; 4) methods for the control of bacterial and fungal diseases of plants and control of insect and nematode pests that attack plants by expression of gene fusions involving holins, C-terminal additions and leader peptides, and optionally, endolysins; 5) methods for increasing the shelf-life of cut flowers, and 6) transgenic plants useful for the production of novel antimicrobial proteins based upon holins. | 2009-05-28 |
20090136915 | Methods and compositions for determining altered susceptibility of HIV-1 to anti-HIV drugs - This invention relates, in part, to methods and compositions for determining altered susceptibility of a human immunodeficiency virus (“HIV”) to the non-nucleoside reverse transcriptase inhibitors (“NNRTIs”) efavirenz (“EFV”), nevirapine (“NVP”), and delavirdine (“DLV”), the nucleoside reverse transcriptase inhibitor AZT, and the integrase strand transfer inhibitors diketo acid 1, diketo acid 2, and L-870,810 by detecting the presence of a mutation or combinations of mutations in the gene encoding HIV reverse transcriptase that are associated with altered susceptibility to the anti-HIV drugs. | 2009-05-28 |
20090136916 | METHODS AND MICROARRAYS FOR DETECTING ENTERIC VIRUSES - The present invention relates to methods, microarrays and kits for detecting one or more human astrovirus serotypes in a sample (e.g., a fecal sample) from an individual. The method includes amplifying nucleic acid molecules of the sample with one or more primers, to thereby obtain an amplified nucleic acid product; contacting the amplified nucleic acid product with one or more serotype specific probes having a nucleic acid sequence that is specific for only one astrovirus serotype in the group of astroviruses being assessed, wherein the nucleic acid sequence includes between about 9 and 25 nucleic acid bases (e.g., SEQ ID NO: 5-24); and detecting the hybridization complex. The presence of hybridization complexes with a serotype specific probe indicates the presence of one or more specific astrovirus serotypes, and the absence of hybridization complexes with a serotype specific probe indicates the absence of the specific astrovirus serotype. Identification of the astrovirus serotypes allows for one to diagnose an individual infected with the serotype. The present invention further includes microarrays having any one of the astrovirus specific probe, or kits having microarrays and reagents for carrying out the assay. | 2009-05-28 |
20090136917 | Systems and methods for viral therapy - Diagnostic methods and compositions associated with viral therapy are provided. In particular, methods, compositions, and kits to measure markers and therapeutic indicator predictive of viral efficacy in antitumor therapy are provided. Therapeutic viruses and combinations and kits for use in the practicing the methods also are provided. | 2009-05-28 |
20090136918 | QUANTIFICATION OF MICROSPHERE SUSPENSION HYBRIDIZATION AND USES THEREOF - A novel suspension hybridization assay was used to determine nucleic acid copy number by flow cytometry. The assay was validated with low copy (lc) products ranging in length from 100 to 2304 bp conjugated to spectrally-distinct polystyrene microspheres. In the example provided herein, these conjugated microspheres were used as multiplex hybridization probes to detect homologous sequences in genomic DNA extracted from cytogenetic cell pellets and labeled with biotin-dUTP. Hybridization was detected with phycoerythrin-labeled streptavidin and analyzed by flow cytometry. Copy number differences were distinguishable by comparing the mean fluorescence intensities of test probes with a diploid reference probe in genomic DNA of patient samples and abnormal cell lines. The assay is capable of distinguishing a single allele and three alleles at a test locus from a biallelic reference sequence, regardless of chromosomal context. The assay is an improvement on previous methods which require prior amplification of locus-specific target DNA because, lc probes provide adequate specificity and sensitivity for accurate copy number determination of homologous targets. Because of its high sensitivity and accuracy, the assay is useful for determination of nucleic acid copy number for a variety of applications, including determination of genomic copy number in humans, animal models of disease and in solution, measurement of transcript levels, forensic DNA analysis, and quality control analysis in agriculture. | 2009-05-28 |
20090136919 | METHOD TO RAPIDLY QUANTIFY MYCOBACTERIA IN INDUSTRIAL FLUIDS - The invention is a method for detecting and quantifying environmental mycobacteria in industrial fluids comprising extracting bacterial DNA from a sample of an industrial fluid; amplifying the extracted DNA; hybridizing an aliquot of the DNA to two or more amplification primers; and detecting the amplification product. | 2009-05-28 |
20090136920 | Diagnostics and therapeutics for diseases associated with serum/glucocorticoid regulated kinase 1 (sgk1) - The invention provides a human SGK1 which is associated with cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of SGK1 as well as pharmaceutical compositions comprising such compounds. | 2009-05-28 |
20090136921 | Association of Breast Cancer DNA Methylation Profiles with Hormone Receptor Status and Response to Tamoxifen - Particular embodiments provide novel and clinically useful DNA methylation predictors of hormone receptor status, and predictors of response to endocrine (e.g., hormonal) and non-endocrine breast cancer therapy. The ESR1 gene, encoding the estrogen receptor (ER) alpha proved to be the preferred predictor of progesterone receptor (PR) status, while methylation of the PGR gene, encoding PR, was the preferred predictor of ER status. ESR1 methylation outperformed hormone receptor status as a predictor of clinical response in patients treated with antiestroges (e.g., tamoxifen), while promoter methylation of the CYP1B1 gene, encoding a tamoxifen and estradiol metabolizing cytochrome P450, predicted response differentially in tamoxifen-treated and non-treated patients. High levels of promoter methylation of the ARHI gene, encoding a RAS-related small G-protein, were shown to be preferred predictors of better survival in patients who had not received tamoxifen therapy. | 2009-05-28 |
20090136922 | Method for carrying out an electrochemical measurement on a liquid measuring sample in a measuring chamber that can be accessed by lines, and corresponding arrangement - Especially in order to carry out the so-called enzyme-coupled DNA hybridisation test in a closed cartridge including a microfluid system, using stored dry reagents, the reagents must be dissolved in the microfluid system and transported into the measuring chamber directly before the measurement. During the dissolution of the reagents in water, air cushions that cannot reach the measuring chamber must absolutely be prevented from forming upstream of the reagent liquid. According to an embodiment of the invention, the liquid measuring sample and the liquid reagents are transported in such a way that the air cushion is directed into the waste line and the measuring sample and the reagents are then introduced into the measuring chamber without any air bubbles. In this way, measuring errors can be avoided. | 2009-05-28 |
20090136923 | PRIMER COMPOSITION FOR DETECTING MYCOBACTERIUM SP. AND THE DETECTION METHOD - Disclosed are a primer composition including two pairs of primers targeting one gene (mpb64) concerning Mycobacterium sp., and a pair of primers targeting a human-derived gene (HLA-DR); and a method for detecting Mycobacterium sp. using a multiplex one-tube nested PCR method in which their primers are used to amplify two genes in one tube at the same time. The method of the present invention may provide a useful guide post capable of clinically diagnosing Mycobacterium sp. in a specimen in a more specific, rapid and convenient manner. | 2009-05-28 |
20090136924 | RAPID GENERATION OF LONG SYNTHETIC CENTROMERIC TANDEM REPEATS FOR MAMMALIAN ARTIFICIAL CHROMOSOME FORMATION - Methods are described for construction of long synthetic arrays of DNA repeats, such as alphoid repeats or other repeat sequences. The methods include concatamerization of DNA into short repeats (for instance using rolling circle amplification or directional in vitro ligation), followed by assembling the short repeats into long arrays by homologous recombination during transformation into microbe cells. These methods can be described generally as Recombinational Amplification of Repeats (RAR). The long arrays are engineered centromere-like regions that allow one to construct mammalian artificial chromosomes with a predefined centromeric region structure. Artificial chromosomes, including human artificial chromosomes with a regulated centromere, and methods of their use are also provided | 2009-05-28 |
20090136925 | IDENTIFICATION OF TERPENOID-BIOSYNTHESIS RELATED REGULATORY PROTEIN-REGULATORY REGION ASSOCIATIONS - Materials and methods for identifying terpenoid regulatory region-regulatory protein associations are disclosed. Materials and methods for modulating expression of a sequence interest are also disclosed. | 2009-05-28 |
20090136926 | Device and method for standardizing nucleic acid concentrations - The present invention relates to a device and a method for normalising nucleic acid concentrations, preferably for normalising nucleic acid concentrations in enzymatic nucleic acid amplification and modification methods. | 2009-05-28 |
20090136927 | RANDOM HOMOZYGOUS GENE PERTURBATION TO ENHANCE ANTIBODY PRODUCTION - The invention reflects enhanced antibody expression of an antibody of interest by cell lines transformed by random homozygous gene perturbation methods to either increase or decrease the expression pattern of a gene of the cell line other than the antibody of interest. The transformed cell line exhibits specific productivity rates, SPR, for the RHGP transformed cell liens of 1.5 or more, as compared with the antibody expressing cell line parents prior to transformation by RHGP. A knock out or anti-sense construct may be devised to reduce expression of the target gene, a promoter may be inserter to enhance expression of the target gene. The antibodies expressed by the transformed cell lines exhibit the binding properties of their parent cell lines prior to transformation with RHGP, and increase Total Volumetric Production of said antibody by said cells in a given volume. | 2009-05-28 |
20090136928 | Compositions and Methods for the Diagnosis and Treatment of Tumor - The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. | 2009-05-28 |
20090136929 | NOVEL IN VITRO METHOD OF QUANTIFYING DEMINERALIZED BONE OSTEOINDUCTIVITY - The present invention provides an in vitro method for determining the osteoinductive potential of a biomaterial. In particular, the method measures the expression of osterix by osteoblast progenitor cells incubated with the biomaterial. In various embodiments, the biomaterial is demineralized bone (DMB) and the progenitor cells are incubated with DMB or proteins extracted from DMB. | 2009-05-28 |
20090136930 | METHOD FOR THE IDENTIFICATION OF MICROORGANISMS BY MEANS OF IN SITU HYBRIDIZATION AND FLOW CYTOMETRY - The invention relates to a combined method for specifically identifying microorganisms by means of in situ hybridization and flow cytometry. The inventive method is particularly characterized by an improved specificity and a shorter duration of the process as opposed to methods known in prior art. | 2009-05-28 |
20090136931 | Novel fluorescent labeling compound - A rare-earth fluorescent complex which forms a fluorescent complex with two or more rare-earth metals such as europium and terbium and can effectively be excited at a wavelength of 340 nm or longer; a fluorescent labeling agent comprising the rare-earth fluorescent complex; a method of fluorescent labeling in which the rare-earth fluorescent complex is used as a labeling agent; and a method of fluorometric analysis in which the fluorescent labeling agent is used. The rare-earth fluorescent complex is characterized by having a cyclic ligand comprising a 4-biphenyl-2,2′:6′,2″-terpyridine skeleton and a 2,6-bis(3′-aminomethyl-1′-pyrazolyl)pyrazine skeleton bonded thereto. | 2009-05-28 |
20090136932 | FIBERS WITH ISOLATED BIOMOLECULES AND USES THEREOF - The present invention relates to compositions, methods, and uses for isolated biomolecule-containing fibers. The invention also relates to isolated, elongated biopolymers such as nucleic acids, polypeptides, lipids, and carbohydrates within fibers. The invention relates to methods of detecting and analyzing biomolecules in fibers using light, electrons, and neutrons. The invention further relates to methods of determining the sequence, structure, and properties of isolated, elongated biopolymers fixed within fibers. | 2009-05-28 |
20090136933 | Method for Determination of Amount of Double-Stranded DNA and Kit for the Determination - A method and kit for electrochemically simply determining with excellent precision the amount of double-stranded DNA does not require an expensive measurement electrode, such as an immobilized enzyme electrode or any high level electrode production technique which can retain uniform surface area accuracy. A method and kit are provided for electrochemically determining the amount of double-stranded DNA in a sample solution based on a residual amount of a substance capable of binding to the double-stranded DNA which is added to the solution in excess amount, in which a buffering substance is added to a sample solution, the buffering substance being capable of allowing an oxidation wave potential of the potential-current curve for the substance capable of binding to the double-stranded-DNA determined in a solution containing the buffering substance to change depending on the concentration of the free substance capable of binding to the double-stranded DNA in the solution. | 2009-05-28 |
20090136934 | TARGETING AND TRACING OF ANTIGENS IN LIVING CELLS - The present invention relates to a method of detecting the presence, amount or subcellular location of an antigenic structure of interest in a cell, comprising the steps of: (a) (i) expressing a fusion protein directed to the antigenic structure of interest in said cell or (ii) introducing a fusion protein directed to the antigenic structure of interest and coupled to a (poly) peptide capable of transducing into said cell; wherein said fusion protein comprises a first (poly) peptide sequence comprising the variable region of a heavy chain antibody of Camelidae and a second (poly) peptide sequence derivable from a fluorescent or chromophoric protein. | 2009-05-28 |
20090136935 | Dye Compounds - The present disclosure provides compounds that may be used as chromogens, fluorochromes, or as both. Said compounds may further be used as substrate for at least one enzyme, wherein said enzyme is capable of processing an aromatic amine group (—NH | 2009-05-28 |
20090136936 | IMMUNOGLOBULIN FC LIBRARIES - Methods and composition for the screening and isolation of aglycosylated antibody Fc domain polypeptides. For example, in certain aspects methods for identifying aglycosylated Fc domains that bind to Fc receptors or preferentially bind to particular Fc receptors are described. Furthermore, the invention provides aglycosylated Fc domains that bind to Fc receptors with high affinity. Enhanced methods and media for prokaryotic based interaction screening are also provided. | 2009-05-28 |
20090136937 | METHODS AND SYSTEMS FOR MONITORING PRODUCTION OF A TARGET PROTEIN IN A NANOLIPOPROTEIN PARTICLE - Provided herein are methods and systems for the monitoring production of a target protein in of a nanolipoprotein particle (NLP) that also includes a scaffold protein and a membrane forming lipid. The target protein is capable of assuming an active form and an inactive form. Monitoring is performed by an indicator protein that is capable of assuming an active form and an inactive form, the active form associated with a detectable activity of the indicator protein, the detectable activity further associated with the active form of the target protein. | 2009-05-28 |
20090136938 | METHODS FOR SEQUENCE-DIRECTED MOLECULAR BREEDING - The present invention provides breeding methods and compositions to enhance the germplasm of a plant by the use of direct nucleic acid sequence information. The methods describe the identification and accumulation of preferred nucleic acid sequences in the germplasm of a breeding population of plants. | 2009-05-28 |
20090136939 | Methods for diagnosis and therapy for pancreatic cancer and composition useful therein - Polynucleotide and polypeptide UKW are specific for pancreatic tumors. Diagnosis of UKW is therefore valuable for diagnosis of pancreatic tumors. Antibodies against UKW are, besides their value in diagnosis, useful as therapeutic agents for the treatment of pancreatic tumors. | 2009-05-28 |
20090136940 | PHOSPHORAMIDITE NUCLEOSIDE ANALOGS - Described are phosphoramidite nucleoside analog monomers, precursors thereof, and oligonucleotides including one or more of the monomers. The monomers can be used during automated synthesis of oligonucleotide derivatives, and allow for incorporation of one or several reporter groups, organic molecules, bio-molecules, small molecules or other chemical groups at the internucleoside phosphotriesters. Oligonucleotides including the monomers have a number of uses in therapeutic, diagnostic, and research applications. | 2009-05-28 |
20090136941 | METHODS, KITS AND COMPOSITIONS PERTAINING TO LINEAR BEACONS - This invention is directed to methods for determining amplified nucleic acid using Linear Beacons | 2009-05-28 |
20090136942 | Analysis of Extracellular RNA - The invention provides methods for detecting tumor-associated RNA in plasma, serum, and other bodily fluids. In particular, the invention provides methods for detecting translocated gene RNA, including fusion gene RNA, in plasma or serum or other bodily fluids. | 2009-05-28 |
20090136943 | METHOD OF DETECTING CANCER USING DELTA-CATENIN - The present invention provides a method for detecting or screening for the presence of cancer in a subject. The method comprises obtaining, providing or collecting a tissue or fluid sample (such as a urine sample) from said subject, and then determining the presence or absence of delta-catenin in said sample, or increased levels of delta-catenin in said sample as compared to a normal or control subject. The presence of delta-catenin in said sample, or increased levels of delta-catenin in said sample, indicating said subject is afflicted with or at least at risk of developing cancer. | 2009-05-28 |
20090136944 | Aberrantly Methylated Genes as Markers of Breast Malignancy - The invention is directed to a method of diagnosing a cell proliferative disorder of breast tissue by determining the methylation status of nucleic acids obtained from a subject. Aberrant methylation of several genes including TWIST, HOXA5, NES-1, retinoic acid receptor beta (RARβ), estrogen receptor (ER), cyclin D2, WT-1, 14.3.3 sigma, HIN-1, RASSF1A, and combinations of such genes serve as markers of breast malignancy. | 2009-05-28 |
20090136945 | COMPOSITIONS AND METHODS FOR ASSESSING DISORDERS - The present invention relates to compositions and methods for disorder (e.g., hyperproliferative disorders, inflammatory disorders) research, diagnosis, and treatment, including but not limited to, bio-markers specific for a particular disorder (e.g., cancer, systemic lupus erythematosus). In particular, the present invention relates to peripheral blood mononuclear cells (PBMCs) as bio-markers specific for particular disorders. | 2009-05-28 |
20090136946 | Automated Enumeration and Characterization of Circulating Melanoma Cells in Blood - The CellTracks® System provides a system to enumerate circulating melanoma cells in blood. The system immunomagnetically concentrates epithelial cells, fluorescently labels the cells and identifies and quantifies circulating melanoma cells. The absolute number of circulating melanoma cells detected in the peripheral blood tumor load is, in part, a factor in prediction of survival, time to progression, and response to therapy. Diagnosis and monitoring of melanoma has been limited by the inability to monitor circulating melanoma cells. The present invention provides a method to enumerate circulating melanoma cells in blood samples. Accordingly, this technology provides a means and device for monitoring disease progression in patients with melanoma. | 2009-05-28 |
20090136947 | METHOD FOR CONDUCTING AN ASSAY FOR NEUTRALIZING ANTIBODIES - A method for conducting a neutralization assay for the determination of the titer of antibodies in a sample is provided which is an improvement over existing neutralization assays because the sensitivity of the reporter gene assay to determine neutralization is increased by the use of a “one time use” cell line transformed with a reporter gene construct. The titer is determined for antibodies specific for a predetermined target molecule that activates the signal transduction activity of a cell surface protein or a pattern recognition receptor or are specific for an antagonist for the predetermined target molecule. | 2009-05-28 |
20090136948 | NANOCONFINEMENT- BASED DEVICES AND METHODS OF USE THEREOF - The present invention provides a device/kit and methods of use thereof in rapid detection of target molecule binding to a cognate binding partner. The methods, inter-alia, make use of a device comprising channels or reservoirs, which are linked to nanochannels, whereby upon application of the cognate binding partner to the nanochannel comprising the target molecule under flow, a detectable change in conductance, capacitance or fluorescence or surface potential occurs. | 2009-05-28 |
20090136949 | PROCESS FOR PREDICTING THE PROGNOSIS OF SQUAMOUS CELL LUNG CANCER - Disclosed in this specification is a method for predicting the prognosis of squamous cell lung cancer by observing regulatory changes in select miRNA sequences. These sequences may include hsa-mir-146b, hsa-mir-191, hsa-mir-206, hsa-mir-299-3p, hsa-mir-155, hsa-mir-15a, hsa-mir-122a, hsa-mir-513, hsa-mir-184, hsa-mir-511, hsa-mir-100, hsa-mir-10a, hsa-mir-453, hsa-mir-379, hsa-mir-202, hsa-mir-21, hsa-mir-126, hsa-mir-494, hsa-mir-432, hsa-mir-370, and combinations of these sequences. | 2009-05-28 |
20090136950 | IMMUNOGLOBULIN DISPLAY VECTORS - Disclosed are mammalian expression vectors for expressing simultaneous expression of immunoglobulins as both a secreted and cell surface bound form. | 2009-05-28 |
20090136951 | QUANTIFICATION OF NUCLEIC ACID MOLECULES USING MULTIPLEX PCR - Described are novel quantification methods and systems that permit, within the context of multiplex PCR, the quantification of all targets within a single reaction tube. The methods employ quantitation algorithms applied to the amplification profiles of internal calibration controls or standards utilizing a plurality of nucleic acid templates that are amplified within the same reaction tube as the nucleic acid target(s) interrogated. | 2009-05-28 |
20090136952 | MANGANESE SUPEROXIDE DISMUTASE VAL16ALA POLYMORPHISM PREDICTS RESISTANCE TO CHEMOTHERAPEUTIC DRUG CANCER THERAPY - The present invention provides, for the first time, the finding that the manganese superoxide dismutase Val16Ala polymorphism is significantly associated with prognosis for cancer patients treated with chemotherapeutic drug therapy. The alanine allele is a novel biomarker that predicts poor response and poor outcome to chemotherapeutic drug cancer therapy. Conversely, the valine allele predicts a good response and a good outcome to chemotherapeutic drug cancer therapy. Therefore, a genotype assay can be used to determine which alleles a subject is carrying, and subsequently this information can be used to determine if chemotherapeutic drug therapy is appropriate, and to customize therapy according to the patient's MnSOD genotype. | 2009-05-28 |
20090136953 | MOLECULAR DIAGNOSTIC METHOD FOR DETERMINING THE RESISTANCE OF A MICROORGANISM TO AN ANTIBIOTIC | 2009-05-28 |
20090136954 | GENETIC MARKERS FOR SCD OR SCA THERAPY SELECTION - Variations in certain genomic sequences useful as genetic markers of Sudden Cardiac Death (“SCD”), or Sudden Cardiac Arrest (“SCA”) risk, are described. Novel genetic markers useful in assessing the risk of SCD, or SCA, and kits containing the same are provided herein. Methods of distinguishing patients having an increased susceptibility to SCD, or SCA, through use of these markers, alone or in combination with other markers, are also provided. Further, methods of assessing the need for an Implantable Cardio Defibrillators (“ICD”) in a patient are taught. | 2009-05-28 |
20090136955 | Protocols for making hepatocytes from embryonic stem cells - This disclosure provides a newly developed strategy and particular options for differentiating pluripotent stem cells into cells of the hepatocyte lineage. Many of the protocols are based on a strategy in which the cells are first differentiated into early germ layer cells, then into hepatocyte precursors, and then into mature cells. The cells obtained have morphological features and phenotypic markers characteristic of human adult hepatocytes. They also show evidence of cytochrome p450 enzyme activity, validating their utility for commercial applications such as drug screening, or use in the manufacture of medicaments and medical devices for clinical therapy. | 2009-05-28 |
20090136956 | Use of Dual-Tags for the Evaluation of Genomic Variable Repeat Regions - The methods and compositions of the present invention allow for the evaluation of a nucleotide expansion, contraction or deletion. In one embodiment, the present invention provides a method for detecting a nucleotide expansion, contraction or deletion comprising amplifying a target nucleic acid sequence with a primer pair, each primer comprising a target specific sequence and a differentiating tag sequence, labeling the target nucleic acid sequence to produce a dual-tagged amplification product; digesting the dual-tagged amplification product to produce an expansion region fragment and an internal control fragment; hybridizing the fragments to separate capture complexes; detecting the signals produced by the labels on the immobilized fragments and comparing the intensity of the signals to detect the nucleotide expansion, contraction or deletion region. | 2009-05-28 |
20090136957 | Methods and compositions for regulating cell cycle progression via the miR-106B family - In one aspect, a method is provided of inhibiting proliferation of a mammalian cell comprising introducing into said cell an effective amount of at least one microRNA-specific inhibitor of at least one miR-106b family member. In another aspect a method is provided for accelerating proliferation of a mammalian cell comprising introducing into said cell an effective amount of at least one miR-106b family member. | 2009-05-28 |
20090136958 | Capture, recapture, and trapping of molecules with a nanopore - In a molecular analysis system, there is provided a structure including a nanopore and first and second fluidic reservoirs. The two reservoirs are fluidically connected via the nanopore. A detector is connected to detect molecular species translocation of the nanopore, from one of the two fluidic reservoirs to the other of the two fluidic reservoirs. A controller is connected to generate a control signal to produce conditions at the nanopore to induce the molecular species to re-translocate the nanopore at least once after translocating the nanopore. This enables a method for molecular analysis in which a molecular species is translocated a plurality of times through a nanopore in a structure between two fluidic reservoirs separated by the structure. | 2009-05-28 |
20090136959 | Novel genes encoding proteins having prognostic, diagnostic preventive, therapeutic, and other uses - The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes. | 2009-05-28 |
20090136960 | METHODS AND COMPOSITIONS FOR THE IDENTIFICATION OF CANCER MARKERS - The present invention relates to methods and compositions for the identification of cancer markers. In particular, the present invention provides methods and compositions for the identification of glycosylated proteins and protein glycosylation patterns. The present invention further provides cancer markers identified using the described methods. | 2009-05-28 |
20090136961 | Novel compositions and methods for identification, assessment, prevention, and therapy of ovarian cancer - The present invention is directed to the identification of markers that can be used to determine whether ovarian cancer is sensitive or resistant to a therapeutic agent. In particular, the present invention is directed to the use of certain combinations of markers, wherein the expression of the markers correlates with sensitivity or resistance to a therapeutic agent. Thus, by examining the expression of the individual markers of a marker set, also referred to as the expression profile of the marker set, it is possible to determine whether a therapeutic agent, or combination of agents, will be most likely to reduce the growth rate of the ovarian cancer. | 2009-05-28 |
20090136962 | DIAGNOSTIC MARKERS FOR CANCER - The present invention provides compositions and methods useful for diagnosing cancer and for monitoring the progression and treatment of cancer, as well as targets for treating cancer. The invention provides sperm and testis associated antigens, such as the protein CABYR, as biomarkers and as targets for chemotherapy. | 2009-05-28 |
20090136963 | METHODS OF CONCENTRATING AN ANALYTE - A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle. | 2009-05-28 |
20090136964 | NOVEL ANTI-HEPARAN SULFATE ANTIBODY, METHOD FOR DETECTION OF HEPARAN SULFATE, AND KIT FOR DETECTION OF HEPARAN SULFATE - An antibody which reacts with N-acetylheparosan and heparan sulfate that is derived from bovine kidney but does not substantially react with heparan sulfate derived from a murine Engelbreath-Holm-Swam tumor tissue, the antibody being produced with a hybridoma which is prepared using a substance composed of a protein and N-acetylheparosan bound to the protein. | 2009-05-28 |
20090136965 | Use of antibody-ligand binding to characterise diseases - We have found that when an antibody binds to (captures) its specific ligand, the antibody-ligand complex is redirected to a route of elimination which is different from that which occurs naturally for the specific ligand that is not bound to an antibody. As a consequence, the amount of antibody-bound ligand in the blood increases over time. The increase in total ligand concentration is a property that is specific to the patient to whom the antibody is administered. Accordingly, the invention provides a method for diagnosing disease in a subject and a method for identifying the most appropriate treatment for a particular patient. Patients who produce more ligand, and thus more antibody-ligand complex, may be more likely to have a disease which is predominantly driven by that ligand. These patients should respond better to a therapy targeted against that ligand. The better understanding of the underlying malfunctions in disease biology provided by the methods of the invention, in respect of the rates of production of natural ligands in health and disease, provides a logical and targeted selection of the appropriate treatments to address specific biological abnormalities. | 2009-05-28 |
20090136966 | Normalization of Complex Analyte Mixtures - The present invention relates to methods and compositions for the normalization of complex analyte mixtures. The invention allows the preparation of profiled samples from highly complex analyte mixtures, allowing the identification of relevant targets or biomarkers. The invention also relates to methods for producing devices, such as a support, suitable for normalization of complex analyte samples. The invention can be used for the normalization of any complex mixture, such as immunogenic libraries, particularly of human source, and to identify or produce biomarkers highly relevant to human traits or conditions. | 2009-05-28 |
20090136967 | Peptides for Discrimination of Prions - The aim of the present invention is to provide a non-intrusive way to isolate, concentrate and monitor the TSE disease-related pathogenic prion protein. The invention described several peptides and their ability to capture PrP | 2009-05-28 |
20090136968 | Novel in vitro methods for studying receptors recognizing volatile compounds - The present invention in particular relates to in vitro methods to identify and/or confirm the binding and/or function of a volatile compound onto a membrane-integrated receptor using volatile-compound-Binding Protein (BP) or compositions thereof. Additionally, the present invention relates to kits comprising receptor proteins recognizing volatile compounds or a candidate receptor for said compound; and; BP, a complex or composition thereof. Said kits may be used to identify and/or confirm the binding and/or function of volatile compounds onto a membrane-integrated receptor. | 2009-05-28 |
20090136969 | Lipoprotein Associated Phospholipase A2, Inhibitors Thereof and Use of the Same in Diagnosis and Therapy - The enzyme Lp-PLA | 2009-05-28 |
20090136970 | NOGO RECEPTOR HOMOLOGUES AND THEIR USE - This invention relates to gene polypeptides and polynucleotides that encode proteins of the Nogo-66 receptor (NgR) family and are therefore called NgR homologue 1 (NgRH1). The invention further relates to their use in identifying compounds that may be agonists or antagonists that are potentially useful in regeneration and protection of the nervous system, and to production of NgRH1 polypepfldes, derivatives, and antibodies. | 2009-05-28 |
20090136971 | MULTIPLEX LIQUID TISSUE METHOD FOR INCREASED PROTEOMIC COVERAGE FROM HISTOPATHOLOGICALLY PROCESSED BIOLOGICAL SAMPLES, TISSUES, AND CELLS - The invention provides methods for multiplex analysis of biological samples of formalin-fixed tissue samples. The invention provides for a method to achieve a multiplexed, multi-staged plurality of Liquid Tissue preparations simultaneously from a single histopathologically processed biological sample, where the protocol for each Liquid Tissue preparation imparts a distinctive set of biochemical effects on biomolecules procured from histopathologically processed biological samples and which when each of the preparations is analyzed can render additive and complementary data about the same histopathologically processed biological sample. | 2009-05-28 |
20090136973 | DETERMINATION OF SHORT-CHAIN SRL ALCOHOL DEHYDROGENASE (DHRS4) AS A BIOMARKER FOR INFLAMMATIONS AND INFECTIONS - The present invention relates to the use of short-chain SRL alcohol dehydrogenase (DHRS4, SEQ ID NO: 1) and peptides thereof as humoral biomarkers for the diagnostic detection and prognosis of the course, and also monitoring the course and therapy of septic inflammations and infections. | 2009-05-28 |
20090136974 | Luciferin Luminescent Substrate of Marine Ostracod Crustacean and Method for Production Thereof - The present invention relates to a method for producing marine ostracod crustacean luciferin or a derivative thereof represented by a general formula (4), characterized by reacting a compound represented by a general formula (2) with a compound represented by a general formula (3): | 2009-05-28 |
20090136975 | Non-desensitizing mutant of the transient receptor potential TRPM5 ion channel - There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods, especially electrophysiological, suffer from a lack of sensitivity, rapid signal loss, low throughput, and are labor intensive. The claimed methods and compositions provide electrophysiology methods that allow prolonged sample testing and fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5. | 2009-05-28 |
20090136976 | Luminescence-based composition - Luminescence-based compositions for measurement of aspartate aminotranserase, alanine aminotransferase, total-bilirubin, creatinine phosphokinase, or lactate dehydrogenase, wherein the chemiluminescence-based composition comprises 0.01-100 mM of luminol, 0.001-1000 U/mL of horseradish peroxidase (HRP), 0-10% of Triton X-100, 0-100 mM PIP, and 5˜500 mM of buffer at pH 6˜9, and the luminescence-base composition measures Aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, or lactate dehydrogenase (LDH). | 2009-05-28 |
20090136977 | NOVEL TARGETS FOR ALZHEIMER'S DISEASE - Compositions and methods for post-translational modifications that include acetylCoA:lysine acetyltransferase activity in the ER lumen are provided. The disclosed compositions and methods are especially suited for the identification of compounds useful for the prevention or treatment of neurodegenerative diseases such as Alzheimer's. | 2009-05-28 |
20090136978 | METHOD FOR MEASURING PHOSPHORIC ACID - In measuring phosphoric acid by the use of an enzyme cycling system using a dehydrogenase together with a thio-NADP, a thio-NAD, a reduced thio-NADP or a reduced thio-NAD as a coenzyme, phosphoric acid is measurable in a wide concentration range from a low concentration to a high concentration by measuring phosphoric acid after previous removal of free phosphoric acid in reagent components for the measurement. | 2009-05-28 |
20090136979 | Class IIA Histone Deacetylase (HDAC) Substrate - The present invention relates to the use of trifluoroacetylated lysine (Boc-L-Lys(ε- trifluoroacetyl)-MCA) as a substrate for histone deacetylases, specific for the class Ha subtype. | 2009-05-28 |
20090136980 | CD10-activated prodrug compounds - The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the CD10 enzyme. Methods of treatment using the prodrug and methods of designing the prodrug are also disclosed. | 2009-05-28 |
20090136981 | METHODS OF MEASURING CELL VIABILITY IN TISSUE ENGINEERED PRODUCTS - This invention provides methods of measuring the viability of cultured cells by detecting one or more cell death-stable proteins or enzyme activities. Methods provided by the invention correlate viability to relative levels of enzyme activity in cell-containing and non-cell-containing fractions of a cell culture. | 2009-05-28 |
20090136982 | CELL SEPARATION USING MICROCHANNEL HAVING PATTERNED POSTS - A micro now device ( | 2009-05-28 |
20090136983 | TARGET SEQUENCES FOR SYNTHETIC MOLECULES - The invention is based on the discovery that certain biarsenical molecules react with specified target sequences, thereby providing a facile means for labeling polypeptides containing the target sequence. The invention is useful in creating stable mammalian cell lines expressing a certain tetracysteine tagged polypeptides, thereby overcoming toxicity associated with native tetracysteine. In addition, the invention allows for orthogonal labeling of polypeptides, thereby allowing for the observation of protein-protein interactions and conformational changes in proteins, for example. | 2009-05-28 |
20090136984 | METHOD AND MEANS FOR ENRICHMENT REMOVAL AND DETECTION OF LISTERIA - The present invention relates to polypeptide fragments of endolysin Ply511, which recognise and bind | 2009-05-28 |
20090136985 | Vascular Aging-Predicting Factor and Utilization of the Same - Abstract A predicting factor for vascular aging and an examination method for an early-stage lesion resulting from vascular aging are provided. Specifically, a predicting factor for vascular aging comprising a human apolipoprotein B100 having a glutathionylated thiol group; a method of examining a lesion resulting from vascular aging contain measurement of a human apolipoprotein B100 having a glutathionylated thiol group in the blood sample; an antibody specifically recognizing an apolipoprotein B100 having a glutathionylated thiol group; a diagnostic agent or a diagnostic kit for an early-stage lesion resulting from vascular aging containing an antibody recognizing a human apolipoprotein B100 having a glutathionylated thiol group, are provided. | 2009-05-28 |