22nd week of 2009 patent applcation highlights part 43 |
Patent application number | Title | Published |
20090137387 | Catalyst for purifying exhaust gas - The present invention provides an exhaust gas purification catalyst comprising a base material, and a two or more layered catalyst coating layer, formed on the base material, wherein the two or more layers have upper and lower layers, and wherein the upper layer contains a large amount of noble metal per liter of the base material more than that of the lower layer, and the lower layer contains a large amount of an oxygen storage/release material per liter of the base material more than that of the upper layer. This exhaust gas purification catalyst has more excellent H | 2009-05-28 |
20090137388 | SOLID CATALYSTS AND FUEL CELL EMPLOYING THE SOLID CATALYSTS - A solid catalyst has a close-packed structure and has a first surface layer and a second surface layer, wherein the first surface layer includes platinum as a main component and the second surface layer contains Pt | 2009-05-28 |
20090137389 | NOVEL COLOR-FORMING COMPOUNDS AND USE THEREOF IN IMAGING MEMBERS AND METHODS - There are described novel rhodamine color-forming compounds. The rhodamine color-forming compounds exhibit a first color when in a crystalline form and a second color, different from the first color, when in an amorphous form. Thermal imaging members containing these color-formers are also described. | 2009-05-28 |
20090137390 | Materials and methods for enhancing nitrogen fixation in plants - The subject invention concerns materials and methods for providing or enhancing nitrogen fixation in plants. The invention provides for the use of nitrogen fixing bacteria that are isolated from nitrogen efficient plants. Plants for which enhanced nitrogen fixation is desired are inoculated with an effective amount of nitrogen firing bacteria of the invention. In an exemplified embodiment, the bacteria is | 2009-05-28 |
20090137391 | Use of benzyladenine to improve emergence of seeds treated with abscisic acid - This invention relates to the use of N | 2009-05-28 |
20090137392 | METHOD TO USE A SYNERGISTIC COMPOSITION - This invention relates to a method to use synergistic composition made of a herbicidally effective amount of a propanil-based product, such as Super Wham® and the at least one ACCase inhibitor herbicide such as Clincher® in an amount sufficient to facilitate the herbicidal activity of the propanil-based herbicide. It has been found that this synergistic composition, when applied to a field of rice, allows a reduction in the amount of herbicide needed, greater flexibility in timing of the application and broad spectrum of weed control. | 2009-05-28 |
20090137393 | 2,4,6-TRIALKYLPHENYL SUBSTITUTED CYCLOPENTANE-1,3-DIONE - The invention relates to novel 2,4,6-trialkylphenyl-substituted cyclopentane-1,3-diones of the formula (I) | 2009-05-28 |
20090137394 | ZEA MAYS NFB2 PROMOTER - The present invention provides non-coding regulatory element polynucleotide molecules isolated from the transcription factor Nuclear Factor B (NFB2) gene of | 2009-05-28 |
20090137395 | Maize event DP-098140-6 and compositions and methods for the identification and/or detection thereof - Compositions and methods related to transgenic glyphosate/ALS inhibitor-tolerant maize plants are provided. Specifically, the present invention provides maize plants having a DP-098140-6 event which imparts tolerance to glyphosate and at least one ALS-inhibiting herbicide. The maize plant harboring the DP-098140-6 event at the recited chromosomal location comprises genomic/transgene junctions having at least the polynucleotide sequence of SEQ ID NO:5 and/or 6. The characterization of the genomic insertion site of the DP-098140-6 event provides for an enhanced breeding efficiency and enables the use of molecular markers to track the transgene insert in the breeding populations and progeny thereof. Various methods and compositions for the identification, detection, and use of the maize DP-098140-6 events are provided. Methods and compositions for improving yield are further provided. | 2009-05-28 |
20090137396 | Piperazine Compounds with a Herbicidal Action - The present invention relates to the use of piperazine compounds of the formula I | 2009-05-28 |
20090137397 | COMPOSITION AND METHOD FOR CROP PROTECTION - This invention relates generally to crop protection compositions and methods for making and using the compositions. More specifically, the invention relates to crop protection compositions utilizing talc and one or more additives providing for improved aqueous suspension of the talc and methods for making such compositions. The present invention also discloses horticultural substrates coated with a crop protective composition utilizing talc and one or more additives providing for improved aqueous suspension of the talc. | 2009-05-28 |
20090137398 | High Temperature Interfacial Superconductivity - High-temperature superconductivity confined to nanometer-scale interfaces has been a long standing goal because of potential applications in electronic devices. The spontaneous formation of a superconducting interface in bilayers consisting of an insulator (La | 2009-05-28 |
20090137399 | METHOD OF FABRICATING SUPERCONDUCTING WIRE AND SUPERCONDUCTING APPARATUS - An object of the present invention is to provide a method of fabricating a superconducting wire that can reduce the fabrication cost and increase the mechanical strength of the superconducting wire, and a superconducting apparatus including a superconducting wire obtained by the method. The present invention provides a method of fabricating a superconducting wire including the steps of forming a superconducting layer on a substrate or an intermediate layer formed on the substrate, forming a silver stabilization layer on the superconducting layer immersing the substrate in a copper sulfate solution after the superconducting layer and the silver stabilization layer are formed thereon, and forming a copper stabilization layer on the silver stabilization layer by electroplating with the copper sulfate solution as a plating bath. A superconducting apparatus including a superconducting wire obtained by the method is also provided. | 2009-05-28 |
20090137400 | SUPERCONDUCTING THIN FILM MATERIAL AND METHOD OF MANUFACTURING THE SAME - A superconducting thin film material that can realize attainment of an excellent property such as a high J | 2009-05-28 |
20090137401 | Chemical Solution Deposition Method of Fabricating Highly Aligned MgO Templates - A superconducting article includes a substrate having an untextured metal surface; an untextured barrier layer of La | 2009-05-28 |
20090137402 | Ditag genome scanning technology - The present invention provides for a method for analyzing large genomes using a process by where the genomic DNA is digested by a small base pair restriction enzyme. The fragments are then cloned and a unique ta-vector-tag is created. The tag-vector-tag fragments are purified and re-ligated to create a “ditag” library, which are then sequenced. In the final step, the sequenced ditags can be mapped back to the genome using software containing mapping algorithms and a unique ditag reference database to provide a method for scanning large portions of the genome in a reduced amount of time and cost. | 2009-05-28 |
20090137403 | METHODS FOR USE IN HUMAN-ADAPTING MONOCLONAL ANTIBODIES - Methods useful for human adapting non-human monoclonal antibodies are disclosed. The methods select candidate human antibody framework sequences from a human germline framework database. | 2009-05-28 |
20090137404 | Single molecule arrays for genetic and chemical analysis - Random arrays of single molecules are provided for carrying out large scale analyses, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the invention comprise concatemers of DNA fragments that are randomly disposed on a regular array of discrete spaced apart regions, such that substantially all such regions contain no more than a single concatemer. Preferably, such regions have areas substantially less than 1 μm | 2009-05-28 |
20090137405 | DETECTION OF NUCLEIC ACID BIOMARKERS USING POLYMERIZATION-BASED AMPLIFICATION - The invention provides methods for highly-specific detection of hybridization of single stranded nucleic acids. The invention also provides methods for target identification which rely on this highly-specific hybridization detection. Targets suitable for detection include, but are not limited to, nucleic acid biomarkers. The methods of the invention can employ an on-chip, DNA polymerase-dependent labeling scheme termed primer extension (PEX) to couple biotinylated deoxyribonucleotide triphosphate (dNTP) molecules to nucleic acid hybrids bound to a solid substrate, allowing for subsequent recognition by biotin-binding-protein-labeled photoinitiators. Surface-initiated polymerization from these surface bound photoinitiators can lead to the formation of macroscale amounts of polymeric material, thereby amplifying the signal from the initial molecular recognition event. | 2009-05-28 |
20090137406 | RNA Detection Method - The present invention provides an RNA detection method detecting, from a reaction system containing a target sample, a target RNA chain originated from the target sample, using a surface having on the surface thereof a polymer substance which contains a first unit having a group derived from a phosphate ester composing the hydrophilic portion of a phospholipid and a second unit having a carboxylic acid derivative group composed of an electron-attractive substitutional group bound to a carbonyl group, while being provided with at least one reaction space, the reaction space having an immobilized nucleic acid primer immobilized therein. | 2009-05-28 |
20090137407 | GENOMIC LIBRARY CONSTRUCTION - Compositions and methods for amplifying nucleic acid sequences from a single cell are provided. Compositions and methods for constructing a genomic library from a single cell are also provided. | 2009-05-28 |
20090137408 | Methods, systems, and apparatus for facilitating the design of molecular constructs - A system and method for aiding in the design of molecular constructs is provided. A feature set associated with a molecular building block in a construct may be determined, wherein the feature set may comprise data indicative of third party rights that restrict use of the molecular segment or the lack of such rights. The method may include steps of defining a molecular structure for use in the construct; searching a database including a plurality of molecular structures and a plurality of rights, each right of the plurality of rights associated with each of the plurality of molecular structures; and displaying rights associated with the defined molecular structures in response to the search of said database. The system may include a library aggregating a plurality of intellectual property rights relating to fabricating biological constructs; a licensing module licensing the intellectual property rights required to make the specific construct for a fee; an accounts receivable module receiving the fee from a potential maker of the specific construct; and an accounts payable module distributing remuneration to the holders of the intellectual property rights required to make the specific construct. | 2009-05-28 |
20090137409 | COMPUTATIONAL METHODS FOR SYNTHETIC GENE DESIGN - The present invention is drawn to methods for designing synthetic nucleotide sequences encoding polypeptides of interest. The methods involve organizing a database of sequences as a set of N-length oligomer sequences and compiling a list of probability scores for each N-length sequence. The probability scores are used to substitute one or more higher-scoring sequences into the parent nucleotide sequence to generate an optimized sequence. The nucleotide sequence of interest may be further optimized by removing either or both of unintended open reading frames or undesired short DNA elements, and/or substituting oligomer sequences to achieve a specific G:C content. These methods may be used for optimizing expression of heterologous genes in any organism, particularly in plants. The method generates synthetic sequences with a composition similar to that of a target database. These synthetic sequences may be used, for example, for regulating pesticidal activity or herbicide resistance in organisms, particularly plants or plant cells. | 2009-05-28 |
20090137410 | METHOD FOR COMPUTER-BASED PROCESSING OF BIOLOGICAL DATA - A method for computer-based processing of biological data, comprising the steps of: selecting a gene as lead gene to be patented; searching homologues for the selected lead gene; creating a patent pool on the basis of the selected lead gene; generating and outputting a pool report for the planned patent application. | 2009-05-28 |
20090137411 | Methods and biochips for detecting small molecule compounds - The present invention discloses methods for detection of small molecule compounds and its specific biochips. Biochips of the present invention comprise a solid support and carrier-linked small molecules immobilized onto the solid support. The invention also provides methods and kits for detection of small molecule compounds using the biochips of the invention. | 2009-05-28 |
20090137412 | CHROMOGENIC IN SITU HYBRIDIZATION METHODS, KITS, AND COMPOSITIONS - The present invention relates to chromogenic (calorimetric) in situ hybridization (CISH) and nucleic acid probes useful for in situ hybridization. Specifically, the present invention provides methods, kits, and compositions for performing bright field cancer diagnostics employing chromogenic in situ hybridization (e.g. to detect gene amplifications, gene translocations, and chromosome polysomy). In preferred embodiments, the present invention provides CISH methods, kits and compositions for detecting HER2 gene status. | 2009-05-28 |
20090137413 | Manipulation of Microparticles In Microfluidic Systems - Arrays of flowable or fixed particle sets are used in microfluidic systems for performing assays and modifying hydrodynamic flow. Also provided are assays utilizing flowable or fixed particle sets within a microfluidic system, as well as kits, apparatus and integrated systems comprising arrays and array members. | 2009-05-28 |
20090137414 | Single molecule arrays for genetic and chemical analysis - Random arrays of single molecules are provided for carrying out large scale analyses, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the invention comprise concatemers of DNA fragments that are randomly disposed on a regular array of discrete spaced apart regions, such that substantially all such regions contain no more than a single concatemer. Preferably, such regions have areas substantially less than 1 μm | 2009-05-28 |
20090137415 | SUBTRACTIVE SEPARATION AND AMPLIFICATION OF NON-RIBOSOMAL TRANSCRIBED RNA (nrRNA) - The invention provides a method of separating non-ribosomal transcribed RNA (nrRNA) fragments from ribosomal RNA (rRNA) and rRNA fragments. The method comprises (i) providing a sample comprising rRNA, rRNA fragments, and nrRNA fragments, and (ii) providing a plurality of probes. The probes hybridize to RNA targeting sequences of at least 50% of the contiguous regions of the rRNA and to rRNA fragments comprising the rRNA targeting sequences. The method further comprises (iii) adding the plurality of probes to the sample, (iv) hybridizing the probes to the rRNA and rRNA fragments to form rRNA-probe complexes and rRNA fragment-probe complexes, and (v) separating the rRNA-probe complexes and rRNA fragment-probe complexes. The invention also provides a method of amplifying an nrRNA fragment, a method of analyzing nrRNA expression, a method of determining the level of nrRNA in a sample, and a kit and system useful in any of the foregoing methods. | 2009-05-28 |
20090137416 | Isolating Cells Expressing Secreted Proteins - A method of detecting and isolating cells that produce a secreted protein of interest (POI) that has a T cell receptor variable domain, comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; b) transfecting said cell simultaneously or subsequently with a second nucleic acid that encodes a POI wherein such POI is secreted; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule. | 2009-05-28 |
20090137417 | Microarray-Based Gene Copy Number Analyses - This invention contemplates an accurate and efficient estimation of gene copy number using oligonucleotide microarrays. The method integrates gene copy number data obtained from perfect match and mismatch probe sequence structure intensities and probe binding affinities. In one embodiment, an accurate determination of single nucleotide polymorphisms (SNPs) sequences is obtained. In another embodiment, an accurate detection and determination of DNA copy number alteration is obtained. In another embodiment, an accurate estimation for RNA gene expression is obtained. | 2009-05-28 |
20090137418 | DNA MICROARRAY HAVING HAIRPIN PROBES TETHERED TO NANOSTRUCTURED METAL SURFACE - A sensor chip and detection device are disclosed. The sensor chip includes a substrate, at least a portion of which is covered by a metal nanoparticle film; a first nucleic acid molecule that is characterized by being able to (i) self-anneal into a hairpin conformation and (ii) hybridize specifically to a target nucleic acid molecule, the first nucleic acid molecule having first and second ends, which first end is tethered to the metal nanoparticle film; and a first fluorophore bound to the second end of the first nucleic molecule. When the first nucleic acid molecule is in the hairpin conformation, the metal nanoparticle film substantially quenches fluorescent emissions by the first fluorophore, and when the first nucleic acid molecule is in a non-hairpin conformation fluorescent emissions by the first fluorophore are surface plasmon-enhanced. | 2009-05-28 |
20090137419 | Sequencing of surface immobilized polymers utilizing microfluorescence detection - Means for simultaneous parallel sequence analysis of a large number of biological polymer macromolecules. Apparatus and methods may use fluorescent labels in repetitive chemistry to determine terminal monomers on solid phase immobilized polymers. Reagents which specifically recognize terminal monomers are used to label polymers at defined positions on a solid substrate. | 2009-05-28 |
20090137420 | METHODS, COMPOUNDS AND COMPOSITIONS WITH GENOTYPE SELECTIVE ANTICANCER ACTIVITY - This invention is directed to methods for screening and identification of compounds capable of selectively eliminating cancer cells with specific loss-of-function alterations, including but not limited to mutations, deletions, hypermethylations, and other types of gene silencing. This invention is also directed to novel compounds that selectively eliminate cancer cells with specific loss-of-function alterations. Furthermore, this invention is directed to methods for production and therapeutic use of compounds that selectively eliminate cancer cells with specific loss-of-function alterations. | 2009-05-28 |
20090137421 | GENETIC SELECTION SYSTEM FOR IDENTIFICATION OF MicroRNA TARGET GENES - There is provided an expression cassette comprising a 3′-UTR cDNA library fragment, mammalian cells transfected with the expression cassette, and kits comprising the same. Furthermore, methods for identifying target genes for microRNAs are provided that utilize the expression cassette hereof. | 2009-05-28 |
20090137422 | Methods for Identifying Modulators of Ion Channels - The invention provides methods for identifying modulators of ion channels without the use of recombinant cell lines over-expressing the ion channel proteins or the use of detection labels. | 2009-05-28 |
20090137423 | Micro-electrode array - A method of fabricating a micro-electrode array comprising the steps of coating an electrode with an insulating polymer coating by screen printing an insulating polymer onto the electrode and then curing said polymer; and sonically ablating the insulating polymer coating to produce a plurality of micro-pores. | 2009-05-28 |
20090137424 | Selective Posttranslational Modification of Phage-Displayed Polypeptides - The invention relates to posttranslational modification of phage-displayed polypeptides. These displayed polypeptides comprise at least one unnatural amino acid, e.g., an aryl-azide amino acid such asp-azido-L-phenylalanine, or an alkynyl-amino acid such as para-propargyloxyphenylalanine, which are incorporated into the phage-displayed fusion polypeptide at a selected position by using an in vivo orthogonal translation system comprising a suitable orthogonal aminoacyl-tRNA synthetase and a suitable orthogonal tRNA species. These unnatural amino acids advantageously provide targets for posttranslational modifications such as azide-alkyne [3+2]cycloaddition reactions and Staudinger modifications. | 2009-05-28 |
20090137425 | SUPPORTS FOR ASSAYING ANALYTES AND METHODS OF MAKING AND USING THEREOF - Described herein are supports for assaying an analyte and methods of making and using thereof. | 2009-05-28 |
20090137426 | MICROARRAY, SUBSTRATE FOR MICROARRAY AND METHODS OF FABRICATING THE SAME - A microarray, a substrate for a microarray and more productive methods of fabricating the microarray and the substrate are provided. The microarray includes a substrate divided into a first region and a second region; a plurality of linkers represented by formula 1 or 2: | 2009-05-28 |
20090137427 | Method for generating hypermutable organisms - Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. The enhanced rate of mutation can be further augmented using mutagens. Moreover, the hypermutability of mismatch repair deficient cells can be remedied to stabilize cells or mammals with useful mutations. | 2009-05-28 |
20090137428 | METHOD OF MANUFACTURING PROBE-IMMOBILIZED CARRIER - A probe-immobilized carrier for detecting a target substance is manufactured such that a spot is prevented from being contaminated with another spot and a probe is prevented from nonspecifically adsorbing a background area in the manufacture of the probe-immobilized carrier and nonspecific adsorption cannot be occurred even after the formation of an array. A substrate containing a reactive group for immobilizing a probe thereon is used and the steps of: (i) supplying a liquid droplet containing a probe on the substrate; (ii) inactivating a reactive group existing in an area other than a supplying area of the substrate, and (iii) removing an unreacted probe existing in the supplied liquid droplet are carried out. | 2009-05-28 |
20090137429 | Temperature-Extended Enzyme Systems - Water-soluble amphoteric surfactants at low concentration thermostabilize enzymes in brine. The thermostabilized enzyme compositions can be used in a method to digest polymers at temperatures and/or salinities at which the enzyme is normally inactivated and/or coagulated without the surfactant. In oilfield applications, the composition can be used in well treatment methods including filtercake removal and polymer viscosity breaking in well treatment fluids. | 2009-05-28 |
20090137430 | Method for simultaneous removal of asphaltene, and/or paraffin and scale from producing oil wells - A method for cleaning oil wells to increase the flow of oil thereof by use of a unique aqueous cleaning emulsion comprising of water, hydrocarbon solvent, and detergent. This one step method provides for the simultaneously cleaning/removal of asphaltene and/or paraffin and scale. This method can be used alone or with the assistance of a wash tool which is a combination pressure and surge wash tool having a nipple assembly. A by-pass port is coupled to the nipple assembly and a diverter cup is coupled to the by-pass port. A plurality of pressure wash cups are positioned on the tool. A pressure wash port is located between the plurality of pressure wash cups and a pump shoe assembly is coupled to a bottom pressure wash cup. | 2009-05-28 |
20090137431 | Oilwell sealant compositions comprising alkali swellable latex - Sealant compositions comprising an alkali swellable latex and a pH increasing material and methods of using the same to service a wellbore are provided. In one embodiment, the sealant composition can be used in a wellbore and includes an alkali swellable latex and a pH increasing material. The sealant composition can have a pH of from about 7 to about 14. In other embodiments, the pH increasing material includes a base-producing material. The base-producing material can include alkali and alkali earth metal carbonates, alkali and alkali earth metal bicarbonates, alkali and alkali earth metal hydroxides, alkali and alkali earth metal oxides, alkali and alkali earth metal phosphates, alkali and alkali earth metal hydrogen phosphates, alkali and alkaline earth metal sulphides, alkali and alkaline earth metal salts of silicates, alkali and alkaline earth metal salts of aluminates, water soluble or water dispersible organic amines, polymeric amine, amino alcohols, or combinations thereof. | 2009-05-28 |
20090137432 | pH Sensitive Emulsion System - An oilfield treatment fluid in the form of an emulsion wherein the emulsion contains at least one treatment agent sequestered within a phase of the emulsion, wherein the emulsion is stable when the pH is maintained within a predetermined range, and breaks to release the at least one treatment agent when the pH is changed to a release pH value outside the predetermined stable pH range. | 2009-05-28 |
20090137433 | Composition And Method For Making A Proppant - The present invention relates to proppants which can be used to prop open subterranean formation fractions. Proppant formulations are further disclosed which use one or more proppants of the present invention. Methods to prop open subterranean formation fractions are further disclosed. In addition, other uses for the proppants of the present invention are further disclosed, as well as methods of making the proppants. | 2009-05-28 |
20090137434 | BINDER RESIN FOR FRICTION MATERIAL, BINDER RESIN COMPOSITION FOR FRICTION MATERIAL, COMPOSITE MATERIAL FOR FRICTION MATERIAL CONTAINING THE SAME, FRICTION MATERIAL AND PRODUCTION METHOD THEREOF - The present invention provides a binder resin for a friction material, which enables high-temperature short-time thermoforming and can omit a post-curing step and suppress the generation of a pyrolysis component at molding; a friction material using the binder resin; and a binder resin composition for a friction material, which is enhanced in the heat resistance and can suppress a rapid increase of the wear amount, and in addition to these properties, which has good dynamic property and enables high-temperature short-time thermoforming. The present invention relates to a binder resin for a friction material which comprises (A) one kind or two or more kinds of polybenzoxazine resins selected from a condensation reaction product of an aminophenol compound with formaldehydes and a condensation reaction product of a bifunctional phenol compound and a bifunctional amine compound with formaldehydes; a binder resin composition for a friction material which comprises: the component (A); and further (B) one kind or two or more kinds of particles selected from an inorganic particle and an inorganic-organic composite particle, and a friction material obtained by the binder resin or binder resin composition. | 2009-05-28 |
20090137435 | Electrical Oil Formulation - Electrical oil formulation comprising a base oil component and an additive, wherein (i) at least 80 wt % of the base oil component is a paraffin base oil having a paraffin content of greater than 80 wt % paraffins and a saturates content of greater than 98 wt % and comprising a series of iso-paraffins having n, n+1, n+2, n+3 and n+4 carbon atoms and wherein n is between 20 and 35; and (ii) an anti-oxidant additive; wherein the base oil component has a flash point of at least 170° C., as determined by ISO 2592. | 2009-05-28 |
20090137436 | Lubricant Additive Packages for Improving Load-Carrying Capacity and Surface Fatigue Life - The present invention provides a multifunctional lubricant additive package or composition for improving load-carrying capacity, pressure resistance, surface fatigue life, and other performance characteristics of a lubricant or base oil. The composition typically includes four components: (a) an alkyl or aryl neutral phosphate, (b) a long-chain organic partial ester, (c) an aryl or alkyl phosphite, and (d) a phenol compound. The present invention further provides a multifunctional lubricant having improved performance characteristics, which are obtained by mixing a lubricant with the above-described multifunctional lubricant additive package or composition. | 2009-05-28 |
20090137437 | Waxlike Ionomers - Through hydrolysis of reaction products of polyethylene or Fischer-Tropsch waxes and α,β-unsaturated carboxylic acids or their derivatives it is possible to gain access to innovative ionomer waxes which, in contrast to known ionomers of low molecular mass, exhibit low melt viscosities even at high degrees of hydrolysis. The ionomer waxes of the invention are suitable inter alia as components of pigment masterbatches, as plastics additives, and for application in polishes, paints, and printing inks. | 2009-05-28 |
20090137438 | Hydrocolloids and Process Therefor - The present invention relates to a shampoo composition comprising a minced polygalactomannan hydrocolloid(s) in combination with a water soluble silicone compound. | 2009-05-28 |
20090137439 | Printer Head and Printer Disk Cleaning Compositions and Methods of Use - The present invention generally relates to compositions and methods for cleaning by contacting a hard disk data storage device, an inkjet printer cartridge head, or the like having residue thereon, particularly organometallic or metal oxide residue, with a cleaning composition of the present invention for a time and at a temperature sufficient to remove the residue. Stirring, agitation, circulation, sonication or other techniques as are known in the art optionally may be used. The hard disk data storage device, an inkjet printer cartridge head, or the like is generally immersed in the cleaning composition. The time and temperature can be determined based on the particular material being removed from a substrate. Generally, the temperature is in the range of from about ambient or room temperature to about 100° C. and the contact time is from about 1 to about 60 minutes. The preferred temperature and time of contact for this invention is about 25 to about 45° C. for about 2 to about 60 minutes. Generally the hard disk data storage device, an inkjet printer cartridge head, or the like may optionally be rinsed after using the composition or the method may be rinse-free, as such rinse is unnecessary with Al | 2009-05-28 |
20090137440 | CLEANING COMPOSITIONS AND METHODS - Cleaning compositions are described comprising an aqueous component; an organic solvent; an anionic surfactant; an amine co-surfactant containing either (a) an N-oxide group or (b) a zwitterionic group; and a nonionic surfactant; in a form of a microemulsion or microemulsion preconcentrate. Methods of cleaning a hard surface using such compositions are also described. | 2009-05-28 |
20090137441 | Fast Release Granules - The present invention provides a granule that releases antioxidants rapidly and a method of preparing an antioxidant granule comprising the steps of: (i) melting a non-ionic surfactant the nonionic surfactant having a starting melting point of 40° C. or above as measured by differential scanning calorimetry; (ii) dissolving an antioxidant in the melted non-ionic surfactant with mixing to form a antioxidant/non-ionic solution; (iii) cooling the antioxidant/non-ionic solution to form a solid whilst forming a particulate matter. | 2009-05-28 |
20090137442 | Stain Removal - The present invention provides a laundry detergent composition comprising an efficient sequestrant. | 2009-05-28 |
20090137443 | Fabric Prespotter with Delivery System - Universal cleaning composition that cleans grease, tar, oil, grass stains, dirt, chocolate, spaghetti sauce, juice, greasy food and is compatible with many different washable fabric types. When soiled portions of washable clothing fabric are treated directly with cleaning composition, with an applicator that sprays, rubs, dabs, or squeezes liquid where necessary, stain or soil is removed after machine washing in hot water, without any damage to clothing fabric. Even stains that are washed, dried and set in fabric can be removed with this cleaning composition and application method. | 2009-05-28 |
20090137444 | Laundry Detergent Acting on Cotton and Comprising Soil-Releasing Cellulose Derivative - A method of improving the cleaning performance of laundry detergents when washing textiles that are made of or contain cotton by contacting the textile with a cellulose derivative that contains, on average, 0.4 to 2.7 alkyl groups and 0.001 to 0.3 carboxyalkyl groups per anhydroglycose monomer unit. | 2009-05-28 |
20090137445 | Inorganic Optical Brightener - The invention relates to novel inorganic brighteners, a process for their preparation and their use for brightening substrates. More specifically, the novel inorganic brighteners are phosphors characterized in that they have (i) an absorption maximum in the range of from 350 to 375 nm; (ii) a steep decrease of the absorption band near 400 nm; (iii) a quantum yield of the phosphorescence of at least 0.8; and (iv) a phosphorescence maximum in the range between 415 and 445 nm. | 2009-05-28 |
20090137446 | DEFOAMER COMPOSITIONS - A composition for defoaming includes an organosilicon compound having radicals that are attached directly to the silicon and that have a specific number of carbon atoms. The composition may also include filler particles, and organopolysiloxane resin, and combinations thereof. | 2009-05-28 |
20090137447 | Coated sodium percarbonate particles - Sodium percarbonate particles with a coating layer which comprises from 70 to 99.8% by weight of anhydrous sodium sulfate and from 0.2 to 20% by weight of a sodium borate, and whose proportion by weight is from 1 to 10% based on the mass of the sodium percarbonate particle, exhibit a high storage stability in detergent and cleaning composition formulations through a synergistic effect of sodium sulfate and sodium borate on the storage stability, and at the same time only have a small content of boron. | 2009-05-28 |
20090137448 | Coated sodium percarbonate particles - Sodium percarbonate particles with a coating layer comprising sodium sulfate in the form of a high-temperature phase of sodium sulfate and/or of a high-temperature phase of a double salt of composition Na | 2009-05-28 |
20090137449 | WASHING OR CLEANING AGENT - Washing- or cleaning-agent shaped elements made of a compressed particulate material, wherein the compressed particulate material encompasses a particulate surfactant granulate having a concentration of nonionic surfactants above 50 wt %, and at least 70 wt % of the particles of said surfactant granulate have a particle size below 1,250 μm, are notable for increased transport and shelf stability, improved cleaning and rinsing performance, and an improved tablet appearance. | 2009-05-28 |
20090137450 | Perfume Compositions - Perfume compositions comprise over 50% by weight of perfume ingredients characterized by possessing (i) a molecular formula possessing from 8 to 13 carbon atoms, including at least one phenyl moiety, substituted or unsubstituted; (ii) an octanol/water partition coefficient (logP) of at least 1.5; (iii) a saturated vapour pressure (SVP) of at least 3 micron Hg at 25 C; and (iv) belonging to one of the following groups (i) ethers of general formula R1OR2; (ii) aldehydes or nitriles of general formula RIX, wherein X is CHO (formyl group) or CN (cyano group); (iii) esters of general formula R1CO2R2; (iv) alcohols or phenols of general formula R1OH; or (v) ketones of general formula R1COR2; wherein R1 and R2 are alkyl, aryl, aralkyl or alkaryl residues, optionally substituted, whose alkyl moieties may be straight-chained or branched, and which may be linked as part of a ring structure. The compositions find particular application in the form of encapsulates for use in consumer products. | 2009-05-28 |
20090137451 | Methods for Assessing Suitability of Cancer Patients for Treatment with Histone Deacetylase Inhibitors - This invention is in the field of cancer therapy and provides the use of E2F1 activity for assessing suitability of a cancer patient for treatment with histone deacetylase inhibitors (HDACIs). | 2009-05-28 |
20090137452 | Antagonists of the bradykinin B1 receptor - The present invention relates to composition of matter involving bradykinin B1 receptor antagonist peptides conjugated to a multivalent vehicle, including peptides conjugated to multivalent PEG. These compositions can be used as therapeutics or prophylactics against diseases or conditions, such as inflammation or pain, linked to the bradykinin B1 receptor. | 2009-05-28 |
20090137453 | COMPOSITION COMPRISING AT LEAST ONE OXAZOLINE TO INHIBIT MIGRATION OF LANGERHANS CELLS, AND USES THEREOF - The invention concerns a composition containing at least an oxazolin, optionally combined with at least a compound such as a metalloprotease inhibitor, a PKC inhibitor, an anti-inflammatory agent, a soothing agent, an immunosuppressor, an ion chelating agent, an alkanolamide, an oxazolidinone and a carbamic acid derivative. The invention also concerns the use of such a composition as medicine, in particular for preventing or treating skin pathologies of allergic and/or inflammatory and/or irritative origin or resulting from a danger signal. The invention further concerns a method for cosmetic treatment of sensitive, irritated, intolerant, allergy-prone, ageing skin and/or mucosa exhibiting skin barrier disorder, or exhibiting non-pathological immunologic imbalance, which consists in applying such composition on the skin and/or mucosa. | 2009-05-28 |
20090137454 | Insulin Derivatives - The present invention is related to insulin derivatives having a side chain attached to an ε-amino group of a Lys residue present in the A-chain or to an ε-amino group of a Lys residue in the B-chain. | 2009-05-28 |
20090137455 | RAPID ACTING AND LONG ACTING INSULIN COMBINATION FORMULATIONS - An injectable formulation containing a combination of a rapid acting insulin and a long acting insulin has been developed wherein the pH of the rapid acting insulin is adjusted so that the long acting insulin, e.g. insulin glargine, remains soluble when they are mixed together. In the preferred embodiment, this injectable basal bolus insulin is administered before breakfast, provides adequate bolus insulin levels to cover the meal, does not produce hypoglycemia after the meal and provides adequate basal insulin for up to 24 hours. Lunch and dinner can be covered by two bolus injections of a fast acting, or a rapid acting or a very rapid acting insulin. Alternatively, through adjustment of the ratio of rapid acting insulin to long acting insulin, the long acting insulin may be shortened to a 12 hour formulation. This rapid and long acting blend is re-administered to the patient at dinner time, providing a safe and effective basal insulin level until morning. As a result, a patient using intensive insulin therapy should only inject three, rather than four, times a day. | 2009-05-28 |
20090137456 | GLUCAGON ANALOGS EXHIBITING PHYSIOLOGICAL SOLUBILITY AND STABILITY - Modified glucagon peptides are disclosed having improved solubility and stability, wherein the native glucagon peptide has been modified by pegylation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 19, SEQ ID NO: 20, SEQ ID NO: 21, or both. | 2009-05-28 |
20090137457 | Pyrimidinedione derivatives - This invention relates to novel compounds that are pyrimidinedione derivatives and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel pyrimidinedione derivatives that are derivatives of alogliptin. This invention also provides compositions comprising one or more compounds of this invention and a carrier, and the use of the disclosed compound and compositions in methods of treating diseases and conditions that are beneficially treated by administering a dipeptidyl peptidase IV (DPP4) inhibitor. | 2009-05-28 |
20090137458 | METHODS AND COMPOSITIONS FOR INCREASING SKIN REMODELING - Skin remodeling is stimulated at the site of blemished skin using an ionic metal-peptide complex to diminish or remove the skin imperfection. The blemish can be a scar, especially surgical or wound scars, acne scars, keloid scars, and the like, or a skin tag, callus, benign skin mole, stretch marks, facial keratosis, thickened sunspots of the skin, or a vitiligo spot. The peptide-ionic metal complex is comprised of an ionic metal selected from copper(II), tin(II), tin(IV), and zinc(II), and salts thereof, and the peptide component can be a hydrolysis of casein, collagen, elastin, meat products, silk protein, or soybean protein, or a chemically synthesized dipeptide, tripeptide, tetrapeptide or the like which complexes with the ionic metal. | 2009-05-28 |
20090137459 | Food Product for Enteral or Oral Nutrition - This invention relates to a food product for enteral or oral nutrition, comprising a novel protein mixture, a novel lipid mixture, as well as carbohydrates, soluble and insoluble fibre, vitamins and minerals, composing a nutritional product adequate for pathologic conditions where there is some kind of impairment to meet nutritional needs with a normal oral diet. | 2009-05-28 |
20090137460 | Cross-linked glycopeptide-cephalosporin antibiotics - This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds. | 2009-05-28 |
20090137462 | PHARMACEUTICAL COMPOSITION COMPRISING CYCLIC SOMATOSTATIN ANALOGUES - The present invention describes parenteral pharmaceutical compositions comprising a somatostatin analogue and novel somatostatin analogues. | 2009-05-28 |
20090137463 | Treatment for Neurodegeneration - Polypeptides which are an N- and/or C-terminally truncated fragment of the human osteopontin (hOPN) sequence or species variant, and which minimally have a 15 amino acid sequence corresponding to amino acids 138 to 152 of hOPN, and polynucleotides encoding said polypeptide, are useful for treatment or prevention of neurodegeneration. | 2009-05-28 |
20090137464 | Therapeutic fibrin-derived peptides and uses thereof - The invention relates to peptides having the general formula (I), or a salt or amide thereof, wherein R | 2009-05-28 |
20090137465 | NOVEL USE - The present invention relates generally to the use of PA131 polypeptides and polynucleotides for healing various wounds arising from different causes. | 2009-05-28 |
20090137466 | Use of GLP-1, Exendin and Agonists Thereof To Delay or Prevent Cardiac Remodeling - The present invention relates generally to the novel use of cardioprotective incretin compounds (CICs) such as GLP-1 and exendin and agonists thereof, including analogs and derivatives to prevent, delay, attenuate, or ameliorate cardiac remodeling. The present invention relates to methods for using CICs for the treatment of conditions associated with cardiac remodeling. The present invention further relates to methods for using CICs for the reduction of the risk or severity of congestive heart failure. | 2009-05-28 |
20090137467 | Bipartite Inhibitors of Bacterial RNA Polymerase - The invention provides a compound having a structural formula (I): X-α-Y, wherein X is an moiety that binds to the Rif pocket of a bacterial RNA polymerase, Y is a moiety that binds to the secondary channel of a bacterial RNA polymerase, and α is a linker. The compound can act as an inhibitor of bacterial RNA polymerase. The invention has applications in control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy. | 2009-05-28 |
20090137468 | CYTOTOXIC FACTORS FOR MODULATING CELL DEATH - Cytotoxic factors having use in modulating cell death, and their use in methods of treating necrosis or apoptosis-related conditions are disclosed. The invention also relates to methods for identifying active agents useful in treating conditions related to cell death. The present inventors have found that different pathogens produce different cytotoxic factor(s) having anticancer activity. The substantially pure cytotoxic factors can be used in a method of treating an infectious disease or a cancer. | 2009-05-28 |
20090137469 | Use of ADNF polypeptides for treating peripheral neurotoxicity - This invention relates to the use of ADNF polypeptides in the treatment of neurotoxicity induced by chemical agents or by disease processes. The ADNF polypeptides include ADNF I and ADNF III (also referred to as ADNP) polypeptides, analogs, subsequences such as NAP and SAL, and D-amino acid versions (either wholly D-amino acid peptides or mixed D- and L-amino acid peptides), and combinations thereof which contain their respective active core sites. | 2009-05-28 |
20090137470 | METHODS OF TREATING CANCER USING NOTCH PATHWAY INHIBITORS - The present invention is based on the discovery that the Notch signaling pathway is associated with cancer. Accordingly, the invention provides methods and compositions for treating cancer. Also provided are methods of modulating the expression and/or activity of proteins in the Notch signaling pathway for use in diagnoses and treatment of cancer in a subject. | 2009-05-28 |
20090137471 | NGF VARIANTS - NGF variants which have trkC-binding activity and trkC-signal inducing activity are provided. The variants optionally have trkA or trkB binding and signal induction activity. The NGF variants of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the NGF variant neurotrophins are also provided. | 2009-05-28 |
20090137472 | CHIMERIC MHC PROTEIN AND OLIGOMER THEREOF - The invention concerns a oligomeric MHC complex comprising at least two chimeric proteins, said chimeric proteins comprising a first section derived from an MHC peptide chain or a functional part thereof and a second section comprising an oligomerising domain derived from an oligomer-forming coiled-coil protein, wherein formation of the oligomeric MHC complex occurs by oligomerisation at the oligomerising domain of the chimeric proteins, and wherein at least two of the first sections are derived from the same MHC peptide chain. The invention also concerns a chimeric protein comprising a first section derived from an MHC peptide chain or a functional part thereof and a second section comprising an oligomerising domain derived from an oligomer-forming coiled-coil protein. The invention further concerns a method of labeling and/or detecting mammalian T cells according to the specificity of their antigen receptor, by combining an oligomeric MHC complex according to the invention and a suspension or biological sample comprising T cells, and detecting the presence of specific binding of said complex and the T cells. Finally the invention concerns primers consisting of DNA sequences for genetic engineering of the above chimeric protein. | 2009-05-28 |
20090137473 | INHIBITION OF MICROTUBULE PROTRUSION IN CANCER CELLS - The present invention generally concerns microtubule protrusions in cancer cells, including detached cancer cells, and inhibition of the protrusions. In particular aspects, the inhibition of the protrusions interferes with attachment of the cell to a vessel wall, and in further aspects the cell is killed by forcing it to enter capillaries and be destroyed, for example by shearing. Inhibition by a variety of agents and methods is contemplated. | 2009-05-28 |
20090137474 | USE OF POLYPEPTIDES HAVING ANTIMICROBIAL ACTIVITY - The present invention relates to the use of polypeptides related to a | 2009-05-28 |
20090137475 | MEDICAMENTS AND PROTEINS BASED ON TGF-BETA MONOMERS FOR THE TREATMENT OF WOUNDS - There is provided the use of monomeric TGF-βs, or there fragments or derivatives, as medicaments. These medicaments preferably comprise monomeric TGF-β3, or fragments or derivatives thereof. The medicaments provided may be used in the acceleration of wounding and/or the inhibition of scarring, in the promotion of epithelial regeneration, or in the prevention and/or treatment of fibrotic disorders. | 2009-05-28 |
20090137476 | Apo-2 ligand variants and uses thereof - The disclosure provides Apo-2 ligand variant polypeptides. Methods of making and chemically modifying Apo-2 ligand variant polypeptides are also provided. In addition, formulations of Apo-2 ligand variant polypeptides are provided. | 2009-05-28 |
20090137477 | Treatment of oropharyngeal candidiasis in cancer patients - A method for local treatment of severe oral lesions caused by oropharyngeal candidiasis in immunocompromised patients, in particularly having head and neck cancer and undergoing or have undergone radiation therapy, by administering a prolonged release mucoadhesive tablet containing at least one active principle of miconazole. Methods of treating xerostomia in cancer patients having severe oral lesions is also provided. | 2009-05-28 |
20090137478 | Hormone normalization therapy and uses therefor - The present invention discloses a novel method of prevention of birth defects, miscarriages and infertility in women. The two therapies, disclosed herein, the hormone normalization therapy and the aromatase inhibitor-hormone normalization therapy, focus on restoring young hormonal levels in women in order to prevent female infertility and miscarriages, guide follicular and oocyte maturation, and promote correct chromosomal segregation in oocytes and early embryos. | 2009-05-28 |
20090137479 | METHODS OF TREATING AND DIAGNOSING LAMINOPATHY - The invention provides a method of treating laminopathy in a subject comprising administering a therapeutically effective amount of centrobin polypeptide to the subject such that laminopathy is treated. The invention also provides a method of identifying an agent that enhances nuclear envelope integrity. The method comprises administering an agent to a cell comprising mutant centrobin, allowing the cell to replicate to form daughter cells, and observing nuclear envelope morphology within the daughter cells. In addition, the invention includes a method for diagnosing or identifying a predisposition to a laminopathy. The method comprises detecting the presence or absence of mutant centrobin in a sample, wherein the presence of mutant centrobin indicates that the subject is suffering from, or is predisposed to develop, a laminopathy. A kit for diagnosing or identifying a predisposition to a laminopathy also is provided. | 2009-05-28 |
20090137480 | TRANSDERMAL DELIVERY SYSTEM FOR DRIED PARTICULATE OR LYOPHILIZED MEDICATIONS - The present invention provides a system for transdermal delivery of dried or lyophilized pharmaceutical compositions and methods using thereof. The system comprises an apparatus for facilitating transdermal delivery of an agent that generates hydrophilic micro-channels, and a patch comprising a therapeutically active agent. The present invention is useful for transdermal delivery of hydrophilic agents, particularly of high molecular weight proteins. | 2009-05-28 |
20090137481 | ANTIMICROBIAL POLYPEPTIDES - The present invention relates to polypeptides having antimicrobial activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides. | 2009-05-28 |
20090137482 | BIOLOGICALLY ACTIVE PEPTIDE AND AGENT CONTAINING THE SAME - A peptide having any one of the amino acid sequences of SEQ ID NO: 1 or 13, preferably a peptide having any one of the amino acid sequences of SEQ ID NOS: 2 to 9 or a peptide having any one of the amino acid sequences of SEQ ID NOS: 10 and 15 to 17, is used as an active ingredient of an agent for promoting growth or differentiation of cells such as osteoblasts, chondroblasts, cementoblasts, bone marrow-derived mesenchymal stem cells and periodontal ligament-derived cells. | 2009-05-28 |
20090137483 | Antagonists of the bradykinin B1 receptor - The present invention relates to composition of matter involving bradykinin B1 receptor antagonist peptides conjugated to a univalent vehicle, including peptides conjugated to univalent PEG. These compositions can be used as therapeutics or prophylactics against diseases or conditions, such as inflammation or pain, linked to the bradykinin B1 receptor. | 2009-05-28 |
20090137484 | Neuronal Network-Interacting Peptide - The invention provides a method for treating a neuronal-associated condition comprising administering a composition comprising a therapeutically effective amount of a polypeptide or a biologically active fragment thereof, the polypeptide or the fragment thereof capable of modulating the interaction between Nogo-ephrinB and/or Nogo-Grb4 third SH3 domain. There are also provided isolated polypeptide or fragment thereof. The invention further provides a method of screening a compound for effectiveness as an agonist or as an antagonist of the polypeptide or fragment thereof according to the invention. | 2009-05-28 |
20090137485 | Antigens Targeted by Pathogenic T Cells in Type 1 Diabetes and Uses Thereof - Provided are polypeptides that are capable of binding a human HLA-A2 MHC class I molecule. Kits comprising these polypeptides in a container are also provided. Further provided are methods for determining whether a mammal is at risk for or has type 1 diabetes. Additionally provided are methods of preventing a CD8 | 2009-05-28 |
20090137492 | METHOD TO REDUCE THE RISK AND/OR SEVERITY OF ANTHRAX INFECTION - Neuropeptides are used to treat mammals who have been exposed to or who are suspected of having been exposed to spores of | 2009-05-28 |
20090137493 | Inhibition of tumor metastases using protein kinase C (PKC) inhibitors - Described are methods for reducing tumor metastasis in an animal by administering an inhibitor of a protein kinase C (PKC) isozyme. | 2009-05-28 |