22nd week of 2014 patent applcation highlights part 40 |
Patent application number | Title | Published |
20140147827 | SYSTEM FOR DOWNLOADINGING STUDENT HOMEWORK AND ANALYZING HOMEWORK AND METHOD THEREOF - A system for downloading student homework and analyzing homework and a method thereof are provided. A teacher uploads a lesson file to a server through a data providing client for a student to download the lesson file conveniently, and the student uploads a homework file to the server through a mobile client for the server to find wrong answer content to perform answering content similarity analysis and provide an analysis result to the data providing client, so as to achieve the technical efficacy of providing digital homework to a student conveniently and analyzing student homework plagiarism fast. | 2014-05-29 |
20140147828 | System and Method For Facilitating Computer-Based Testing Using Traceable Test Items - A computer-based method for facilitating a computer-based test is provided. The method includes storing a test question in a memory of a server facility coupled to a network, associating a unique identifier with the test question, generating a traceable test question based on the test question and the unique identifier, the traceable test question including the unique identifier, and sending the traceable test question to a test taker computer coupled to the network for display to the test taker. | 2014-05-29 |
20140147829 | WEARABLE FOOD NUTRITION FEEDBACK SYSTEM - A see-through, head mounted display and sensing devices cooperating to provide feedback on food items detected in the device field of view. Feedback can include warnings based on personal wearer needs, general nutrition information, food consumption tracking and social interactions. The system includes one or more processing devices in communication with display and the sensors which identify food items proximate to the apparatus, determine feedback information relevant to a wearer of the apparatus; and render feedback information in the display. | 2014-05-29 |
20140147830 | COMPOSITIONS AND METHODS RELATED TO ORGAN OR TISSUE DECELLULARIZATION - Embodiments include methods for decellularizing an organ or tissue comprising conditioning the organ or tissue to be decellularized by exposing the organ or tissue to an electric current, as well as methods of using such decellularized organs or tissues. | 2014-05-29 |
20140147831 | METHODS FOR FORMING NORMAL REGENERATED TISSUES, THE NORMAL REGENERATED TISSUES AND METHODS FOR ASSESSING SENSITIVITIES AND SO ON - A normal regenerated tissue is formed by exposing to radiation a connective tissue or a supporting tissue originating in an organ to thereby form a feeder layer and then transplanting epithelial cells thereon to form a stratified structure. By conveniently and surely providing regenerated tissue by the 3-dimensional culture with the use of a human-origin normal tissue as a base, it is possible to construct systems for assessing effects and side effects of chemicals such as drugs or assessing sensitivities thereof with the use of regenerated tissues as models of corresponding tissues respectively. | 2014-05-29 |
20140147832 | SIGNAL BASED SAMPLE PREPARATION - Described is a system and method for detecting whether a biological event has occurred in a cellular sample, and then activating a fluidics system to fix the cell at the point in time with the event occurred. In one example, a sample preparation system includes a camera linked to a confocal microscope that is interrogating a cellular sample. Once a detectable event, such as a binding event, has occurred, the sample preparation system releases a fixative to fix the cell at the point in time when the event was detected. | 2014-05-29 |
20140147833 | BASE RECOGNITION BASED ON THE CONFORMATION CHANGE OF A MOTOR MOLECULE - A mechanism is provided for base recognition in a nanopore detection system. A complex including a long chain polynucleotide and a motor molecule is formed. The complex is localized in a nanopore of the nanopore detection system. A conformation change of the motor molecule is detected while localized in the nanopore by an ionic current having an amplitude and duration time. The detected conformation change includes the motor molecule forming a base pair by incorporating a single base of the long chain polynucleotide and by synthesizing a complementary base of the single base. An identity of the single base of the long change polynucleotide is determined from the amplitude and the duration time of the conformation change of the motor molecule for the base pair. | 2014-05-29 |
20140147834 | KIT FOR DETECTING BOVINE LEUKEMIA VIRUS(BLV), AND USE THEREOF - A kit for detecting Bovine leukemia virus (BLV) according to the present invention includes: a first PCR primer being oligonucleotide including successive 20 bases or more in the base sequence denoted by SEQ ID NO: 1, the first PCR primer being oligonucleotide having 50 bases or less; and second PCR primer being including successive 20 bases or more in the base sequence denoted by SEQ ID NO: 2, the second PCR primer being oligonucleotide having 50 bases or less is included. | 2014-05-29 |
20140147835 | BASE RECOGNITION BASED ON THE CONFORMATION CHANGE OF A MOTOR MOLECULE - A mechanism is provided for base recognition in a nanopore detection system. A complex including a long chain polynucleotide and a motor molecule is formed. The complex is localized in a nanopore of the nanopore detection system. A conformation change of the motor molecule is detected while localized in the nanopore by an ionic current having an amplitude and duration time. The detected conformation change includes the motor molecule forming a base pair by incorporating a single base of the long chain polynucleotide and by synthesizing a complementary base of the single base. An identity of the single base of the long change polynucleotide is determined from the amplitude and the duration time of the conformation change of the motor molecule for the base pair. | 2014-05-29 |
20140147836 | METHODS AND APPARATUS FOR IMAGING MOLECULES IN LIVING SYSTEMS - Methods and apparatus are disclosed for imaging molecular interactions in living cells at high resolution, low light levels and high acquisition speeds. | 2014-05-29 |
20140147837 | METHOD FOR ANALYZING BLOOD CELLS AND BLOOD CELL ANALYZER - A method for analyzing blood cells includes: preparing a measurement specimen for classifying white blood cells, by mixing a sample with a reagent in order to hemolyze red blood cells contained in the sample and to fluorescently stain nucleic acid in white blood cells contained in the sample; detecting, by flowing the prepared measurement specimen in a flow cell, fluorescence emitted from each blood cell in the measurement specimen and two types of scattered light at respective different angles, and obtaining a fluorescence signal and two types of scattered light signals; and classifying the white blood cells into at least four groups and detecting neoplastic lymphocytes, by performing analysis using at least three types of parameters based on the obtained fluorescence signal and two types of scattered light signals. | 2014-05-29 |
20140147838 | METHOD FOR MULTICOLOR CODETECTION OF MICRORNA AND PROTEINS - The present invention is directed to systems and methods of conducting a purchase transaction of eligible goods or services using a stored value associated with an indicia. Methods in accordance with the invention may include steps | 2014-05-29 |
20140147839 | MICROVESICLE-BASED ASSAYS - Methods are disclosed herein for assaying a biological sample or a bodily fluid obtained from a subject by isolating, obtaining or using a microvesicle fraction from the biological sample or bodily fluid and detecting in the microvesicle fraction the presence or absence of a genetic aberration in an IDH1, IDH2, TP53, PTEN, CDKN2A, NF1, EGFR, RB1, PIK3CA, or BRAF gene. The methods may be used for aiding the diagnosis, prognosis, monitoring, or therapy selection in relation to a disease or other medical condition (e.g., a glioma) in a subject. | 2014-05-29 |
20140147840 | METHOD OF LABELING A TARGET NUCLEIC ACID - Methods of labeling and detecting a target nucleic acid by incubating a target nucleic acid with a terminal transferase to extend a terminus of the target nucleic acid and provide an extended region; hybridizing the extended region of the target nucleic acid with a template polynucleotide having a nucleotide sequence complementary to the extended region to obtain a hybridization product; and incubating the hybridization product with a nucleic acid polymerase and either a deoxynucleotide triphosphate (dNTP) having a detectable label or nucleotide triphosphate (NTP) having a detectable label to further extend the extended target nucleic acid. | 2014-05-29 |
20140147841 | Method of Enzymatic Gene Chip Detection Kit - A gene chip is provided for detection. When used on clinical detection, the gene chip directly detects blood without magnification. Gene expressions are examined with high sensitivity and convenience simultaneously. | 2014-05-29 |
20140147842 | METHOD FOR DETECTING SINGLE NUCLEOTIDE POLYMORPHISMS - An object of the present invention is to provide a method for rapidly and simply detecting single nucleotide polymorphisms. The present invention is a method for detecting single nucleotide polymorphisms, comprising analyzing wild-type and mutant-type products amplified by an AS-PCR method using ion-exchange chromatography. | 2014-05-29 |
20140147843 | METHOD FOR QUANTIFYING HUMAN DNA USING AN INTERNAL CONTROL - The present invention relates to a method for quantifying and/or detecting one or more nucleic acids of a genome in a sample, wherein in an amplification reaction, (i) a first nucleic acid is amplified, the locus that is amplified is a multicopy locus (MCL) within the genome, wherein the locus shares at least 80% sequence identity to a sequence according to SEQ ID NO. 1 over a stretch of 80 base pairs, and wherein the multicopy locus has copies on at least two different chromosomes, (ii) a second nucleic acid that has been added as an internal control (IC) is also amplified, and (iii) the amount of amplification product from the amplification of the first nucleic acid is determined. | 2014-05-29 |
20140147844 | Nucleic Acids, Methods and Kits for the Diagnosis of DYT6 Primary Torsion Dystonia - This invention relates generally to the THAP1 gene and mutations in this gene, as well as the THAP1 protein and mutations in this protein, that are associated with dystonia. The invention relates to the identification, isolation, cloning and characterization of the DNA sequence corresponding to the wild type and mutant THAP1 genes, as well as isolation and characterization of their transcripts and gene products. The invention further relates to methods and kits useful for detecting mutations in THAP1 that are associated with dystonia, as well as to methods and kits useful for diagnosing dystonia. The present invention also relates to therapies for treating dystonia, including gene therapeutics and protein/antibody based therapeutics. | 2014-05-29 |
20140147845 | CONCATAMERIC LIGATION PRODUCTS: COMPOSITIONS METHODS AND KITS FOR SAME - The present teachings relate to methods, compositions, and kits for detecting one or more target polynucleotide sequences in a sample, and methods compositions and kits for forming concatameric ligation products. In some embodiments of the present teachings, oligonucleotides are hybridized to complementary target polynucleotides and are ligated together to form a concatameric ligation product. In some embodiments of the present teachings, the concatameric ligation product can be amplified, and the identity and quantity of the target polynucleotides determined based on sequence introduced in the ligation reaction. Some embodiments of the present teachings provide methods for removing unligated probes from the reaction mixture. Some embodiments of the present teachings provide for highly multiplexed detection, identification, and quantification of a plurality of target polynucleotides using a variety of analytical procedures. | 2014-05-29 |
20140147846 | DETECTION OF SEQUENCE VARIANTS IN THE HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) GENE - Provided herein are methods for detecting and identifying sequence variants in the human epidermal growth factor receptor (EGFR) gene, and compositions and kits for performing such methods. In particular, nucleic acid amplification and fluorescence detection methods are provided for the detection and identification of EGFR sequence variants. | 2014-05-29 |
20140147847 | Methods for producing polypeptides in enzyme-deficient mutants of fusarium venentatum - The present invention relates to methods of producing a polypeptide, comprising: (a) cultivating a mutant of a parent | 2014-05-29 |
20140147848 | COMPOSITIONS AND METHODS FOR LINEAR ALKYLBENZENE SULFONATE (LAS) RISK ASSESSMENT - The present disclosure provides a method for assessing the environmental effects of alkylbenzenesulfonate (LAS). For example, the method includes contacting a population of cells with a sample, measuring an expression level of one or more LAS biomarkers in the cell population, comparing the level of expression of the one or more LAS biomarker to one or more reference values corresponding to the one or more LAS biomarkers, and determining an LAS risk associated with the sample. | 2014-05-29 |
20140147849 | QUANTITATION OF HUMAN GENOMIC AND MITOCHONDRIAL DNA - Methods are provided for determining, in a single polymerase chain reaction (PCR) reaction, the quantity, quality, and gender of origin of DNA in a sample, and whether or not the sample contains PCR amplification inhibitors. The methods involve carrying out a single PCR multiplex reaction utilizing primer sets specific for amplifying: the human amelogenin locus; an X- and/or Y-chromosome specific gene that is shorter than the amelogenin gene; at least one mitochondrial DNA sequence, and preferably two differently-sized mitochondrial sequences; and a heterologous, non-human reporter gene. | 2014-05-29 |
20140147850 | DIABETES-RELATED BIOMARKERS AND METHODS OF USE THEREOF - The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify individuals at risk of developing Diabetes. | 2014-05-29 |
20140147851 | METHODS AND KITS FOR DETECTING CELL-FREE PATHOGEN-SPECIFIC NUCLEIC ACIDS - The present invention relates to a method for detecting a target nucleic acid derived from a pathogen in a subject. The method comprises (a) amplifying the nucleic acid sequence of the target nucleic acid, which is obtained from a cell-free fraction of a blood sample from the subject, to produce a double stranded DNA is produced, and (b) detecting the double stranded DNA. The presence of the double stranded DNA indicates the presence of the target nucleic acid in the subject. Also provided are kits for detecting a target nucleic acid derived from a pathogen in a subject. | 2014-05-29 |
20140147852 | NUCLEIC ACID AMPLIFICATION - In some embodiments, the present teachings provide methods for nucleic acid amplification, comprising forming a reaction mixture, and subjecting the reaction mixture to conditions suitable for nucleic acid amplification. In some embodiments, methods for nucleic acid amplification include subjecting the nucleic acid to be amplified to partially denaturing conditions. In some embodiments, methods for nucleic acid amplification include amplifying without fully denaturing the nucleic acid that is amplified. In some embodiments, the methods for nucleic acid amplification employ an enzyme that catalyzes homologous recombination and a polymerase. In some embodiments, methods for nucleic acid amplification can be conducted in a single reaction vessel. In some embodiments, methods for nucleic acid amplification can be conducted in a single continuous liquid phase of a reaction mixture, without need for compartmentalization of the reaction mixture or immobilization of reaction components. In some embodiments, methods for nucleic acid amplification comprise a amplifying at least one polynucleotide onto a surface under isothermal amplification conditions, optionally in the presence of a polymer. The polymer can include a sieving agent and/or a diffusion-reducing agent. | 2014-05-29 |
20140147853 | Method for Predicting Respiratory Toxicity of Compounds - The invention provides methods for analyzing and predicting the in vivo respiratory toxicity of a compound (e.g., pharmaceutical, biological, cosmetic, or chemical compounds) or composition comprising a combination of an in vitro mammalian cell model with multiple endpoint analysis, and time and concentration response curves. The methods allow the determination of a predicted in vivo respiratory toxicity value of a compound without the use of animals, with a high degree of accuracy. The methods comprise detecting any combination of cell viability markers and expression levels of genes implicated in respiratory toxicity and/or sensitization, such as pro-inflammatory response genes, combining the viability and gene expression level data with concentration response and time response data, conducting a computational analysis, and comparing test compound data to a database of known respiratory toxicants/sensitizers to predict and/or analyze the respiratory toxicity. An indication of organ specificity is provided by a toxicity index, which is determined by comparing mean 10 | 2014-05-29 |
20140147854 | METHOD FOR DETECTING A TARGET PARTICLE - This method for detecting a target particle has: (a) a step for preparing a sample solution containing target particles and one type or two or more types of a luminescent probe that binds to the target particles, and allowing two or more molecules of the luminescent probe to bind per one molecule of the target particles in the sample solution, and (b) a step for calculating the number of molecules of target particles bound to the luminescent probe present in the sample solution prepared in step (a) by a scanning molecule counting method by using as an indicator thereof the strength of light signals of the individually detected particles, and the luminescent probe is one type or two or more types of a luminescent probe to which the same type of luminescent substance is bound. | 2014-05-29 |
20140147855 | Method for Extracting RNA from Fixed Embedded Tissue - The present invention provides methods for extracting RNA from formalin fixed embedded tissue wherein the extracted RNA provides reliable results in assays for RNA quantity such as PCR assays. | 2014-05-29 |
20140147856 | Intestinal Permeability Assay for Neurodegenerative Diseases - A method of identifying a subject at risk of developing or having a neurodegenerative disorder is provided. The method includes obtaining a biological sample from the subject and assaying a level of a marker of intestinal permeability in the sample. The method further includes comparing the subject's level to a control level for the marker of intestinal integrity and identifying the subject having an increased intestinal permeability relative to the control intestinal permeability as having an increased risk of developing or having a neurodegenerative disorder. A method of monitoring the efficacy of a treatment for a neurodegenerative disorder is also provided. | 2014-05-29 |
20140147857 | METHODS FOR DIAGNOSIS PROGNOSIS AND METHODS OF TREATMENT - The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN. | 2014-05-29 |
20140147858 | MONOCLONAL ANTIBODIES AGAINST PCBP-1 ANTIGENS, AND USES THEREFOR - The present invention provides and includes monoclonal antibodies specific or preferentially selective for PCBP-1 antigens, as well as methods utilizing these antibodies to determine the severity of breast cancer in a patient. | 2014-05-29 |
20140147859 | Venlafaxine Assay - The invention describes antibodies that bind venlafaxine and O-desmethylvenlafaxine. The antibodies are derived from novel haptens and immunogens and are used in methods and kits to detect and quantify venlafaxine and O-desmethylvenlafaxine. The invention also describes novel detecting agents which can be used in the methods and kits of the invention. | 2014-05-29 |
20140147860 | Acoustic Cytometry Methods and Protocols - Various embodiments disclosed herein comprise acoustic cytometry based methods, kits, computer software methods and systems to analyze a variety of bioparticles. In one embodiment, a method for analyzing bioparticles comprises: acoustically focusing one or more bioparticles through an interrogation zone; optically exciting the one or more bioparticles in the interrogation zone with an excitation source; detecting an optical signal from the bioparticles; and analyzing the optical signal to characterize at least one quality or quantity parameter of the bioparticles. Properties of biomolecules that may be analyzed include but are not limited to cell proliferation analysis, live/dead cell discrimination, cell cycle analysis, basic phenotyping, immunophenotyping, rare-event detection, apoptosis, phagocytosis, pinocytosis, detection of phosphoproteins, detection of one or more cellular markers, detection of one or more intracellular marker, detection of cancer cells, detection of pathological markers on a cell, microbial cell analysis and/or picophytoplankton analysis. | 2014-05-29 |
20140147861 | MARKERS TO IDENTIFY PRIMARY CELLS FROM TUMOR BIOPSIES - A process that utilizes a panel of primary monoclonal antibodies (mAbs) specific for cell markers that are directly conjugated to fluorophores (Alexa Fluor dyes and Quantum Dots). The mAb-fluorophore conjugates are used to interrogate the presence or absence and relative level of expression of each of the cell markers using laser scanning confocal microscopy. Complex tissues contain various cellular subsets each of which contribute in different ways to the biological behavior and each of which has, if selected well, a unique pattern of cell marker molecules capable of being identified by monoclonal antibodies and therefore provide a specific phenotype. The cell markers may be cell surface or intracellular in location. The expression patterns of heterogeneous mixtures of cells are detected by the mAb-fluorophore conjugates, and are used to decipher the identity of the cells based on their expression or lack thereof, of the cell markers. | 2014-05-29 |
20140147862 | MICROFLUIDIC APPARATUS AND METHOD OF ENRICHING TARGET CELLS BY USING THE SAME - A microfluidic apparatus capable of being mounted on a rotation driving unit. When mounted on the rotation driving unit and rotated, a fluid flow is induced in the apparatus due to a centrifugal force. the microfluidic apparatus includes a sample supplying unit that comprises a sample chamber to house a sample and provides a fluid including a target material in which fine beads are bound to a target cell in the sample; a density-gradient separation unit that houses a density gradient material with a lower density than the target material, and receives the fluid from the sample supplying unit to separate the target material from the fluid based on a density difference; a fluid supplying channel connecting the sample supplying unit to the density-gradient separation unit to form a passage of the fluid; and a fluid supplying valve provided to the fluid supplying channel to selectively allow a flow of the fluid. | 2014-05-29 |
20140147863 | METHODS AND DEVICES FOR DIAGNOSING ALZHEIMERS DISEASE - Methods and devices for predicting, diagnosing, monitoring, or determining Alzheimer's disease in a human are described. In particular, methods and devices for predicting diagnosing, monitoring, or determining AD using measured concentrations of a combination of three or more analytes in a test sample taken from the human are described. | 2014-05-29 |
20140147864 | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE - The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Proheparin-binding EGF-like growth factor, Tenascin C, Angiopoietin-related protein 4, Fibroblast growth factor 19, Fibroblast growth factor 21, Heparin-binding growth factor 1, Angiopoietin-related protein 6, Proepiregulin, Probetacellulin, Amphiregulin, Angiogenin, Thrombospondin-2, and Collagen alpha-1 (XVIII) chain as diagnostic and prognostic biomarkers in renal injuries. | 2014-05-29 |
20140147865 | METHODS FOR DIAGNOSING DEGENERATIVE JOINT DISEASE - The invention provides methods for diagnosing degenerative joint disease in an animal by collecting a saliva sample from an animal; determining the amount of at least one diagnostic agent selected from the group consisting of interferon gamma, interferoninducible protein-10, interleukin-2, and total saliva protein in the saliva sample; comparing the amount of diagnostic agent found in the saliva sample to a corresponding amount of the same diagnostic agent found in a saliva sample from one or more comparable control animals that do not suffer from degenerative joint disease; and diagnosing that the animal is susceptible to or suffering from degenerative joint disease if the amount of diagnostic agent in the saliva sample from the animal is greater than the amount of same diagnostic agent found in the saliva sample from the one or more comparable control animals. | 2014-05-29 |
20140147866 | COMPOUND FOR INHIBITING SNAIL-P53 BINDING AND THERAPEUTIC AGENT FOR CANCER INCLUDING THE COMPOUND AS EFFECTIVE COMPONENT - Provided are compounds for inhibiting Snail-p53 binding and therapeutic agents for cancer including the compounds as an effective component. The Snail-p53 binding inhibitors induce expression of p53 in K-Ras mutant cell lines, thereby enabling effective treatment or prevention of K-Ras mutant cancer, such as, pancreatic cancer, lung cancer, cholangioma, and colon cancer, of which diagnosis or treatment is not easy. | 2014-05-29 |
20140147867 | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND RISK PREDICTION IN HEART FAILURE - The present invention relates in part to diagnosing the occurrence of heart failure, particularly in subjects who exhibit a normal body fluid level of a natriuretic peptide. The present invention further relates in part to assigning an outcome risk (e.g., worsening cardiac function or a mortality risk, a risk of rehospitalization) to a subject. The methods comprise performing one or more assays that detect one or more biomarkers selected from the group consisting of WAP4C, ESAM, LTBR, Mesothelin, and Syndecan-1 performed on a body fluid sample obtained from a subject, and assigning diagnosis or risk based, at least in part, on the result(s) obtained thereby. | 2014-05-29 |
20140147868 | COBALAMIN ASSAY - The present invention provides a specific binding partner for holoTC having a specificity for holoTC over apoTC of at least 40-fold and an assay method for assaying for holoTC in a sample, the method comprising contacting the sample with a specific binding partner for holoTC and detecting the resultant conjugates. | 2014-05-29 |
20140147869 | Method and Kit for Measuring Cholesterol in Low-Density Lipoproteins - A new measurement method by which LDL cholesterol can be measured readily and precisely is provided. The measurement method is for measuring LDL cholesterol in a sample. | 2014-05-29 |
20140147870 | NON-PRECIPITATING BODILY FLUID ANALYSIS SYSTEM - A bodily fluid analyzer including a dry test strip impregnated with a reagent providing a non-precipitating reaction to exclude non-desired analytes. The reagent complexes the non-desired analytes so they remain in solution but cannot participate in the test reaction. Red blood cells are removed from the detection area by slowing their vertical movement and stopping flow when the detection membrane is saturated. | 2014-05-29 |
20140147871 | METHOD AND MEDIUM FOR DETECTING THE PRESENCE OR ABSENCE OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS IN A FIRST GENERATION BIOLOGICAL TEST SAMPLE - A presence/absence test for | 2014-05-29 |
20140147872 | OXIDIZABLE SPECIES AS AN INTERNAL REFERENCE IN CONTROL SOLUTIONS FOR BIOSENSORS - Testing of the performance of an electrochemical meter used to measure the presence of an analyte in a biological sample, particularly glucose in whole blood, includes introducing a control solution containing a predetermined amount of the analyte and a predetermined amount of an internal reference compound. The internal reference compound is selected such that it is oxidized at a potential greater than that used to oxidize the analyte, thereby making it possible to distinguish the control solution from a biological sample. | 2014-05-29 |
20140147873 | SURFACE DISPLAY OF CELLULOLYTIC ENZYMES AND ENZYME COMPLEXES ON GRAM-POSITIVE MICROORGANISMS - In various embodiments a system is provided that displays heterologous proteins on the surface of a Gram-positive microorganism. In certain embodiments the system displays proteins using a sortase transpeptidase to covalently anchor proteins to the cell wall of the microbe. Novel bacterial strains are provided to exploit this system to display cellulase enzymes and multi-enzyme complexes on the surface of Gram-positive microorganisms (e.g., | 2014-05-29 |
20140147874 | BIOMARKERS OF CARDIAC ISCHEMIA - The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing cardiac ischemia. In a specific embodiment, a method for diagnosing acute cardiac ischemia in a patient comprises the steps of (a) measuring the levels of one or more post-translationally modified and unmodified serum albumin peptides in a sample collected from the patient using SRM-MS, wherein the post-translationally modified peptides are phosphorylated and/or cysteinylated; (b) comparing the levels of the measured one or more post-translationally modified serum albumin peptides to the levels of the measured one or more unmodified serum albumin peptides; and (c) correlating the compared levels to a patient having ACI or to a patient not having ACI, thereby providing the diagnosis. | 2014-05-29 |
20140147875 | DISEASE SEVERITY INDEX FOR ASSESSMENT OF CHRONIC LIVER DISEASE AND METHOD FOR DIAGNOSIS OF THREE DISTINCT SUBTYPES OF PRIMARY SCLEROSING CHOLANGITIS - A Disease Severity Index (DSI) is provided for assessment of chronic liver disease in a patient using non-invasive liver function test results. A DSI was derived from non-invasive liver function test results based on hepatic blood flow. The DSI is used in methods for prediction of clinical outcomes, prediction of response to antiviral treatment, and assessment of progression of chronic liver diseases. Non-invasive methods to diagnose three distinct categories of patients with Primary Sclerosing Cholangitis (PSC) are provided. The methods can be used to diagnose PSC patients as Slow Progressors, Moderate Progressors and Rapid Progressors. | 2014-05-29 |
20140147876 | MULTI-LAYER DEVICE FOR SELECTIVELY DETERMINING MAGNESIUM ION - The invention relates to devices comprising a sensor layer capable of binding magnesium ions and a scavenging layer that preferentially binds to calcium ions in the presence of both magnesium ions and calcium ions. The sensor layers can comprise known or novel luminionophores. The invention further relates to methods of selectively detecting magnesium ion concentration in the presence of calcium ions. | 2014-05-29 |
20140147877 | METHOD AND APPARATUS FOR INCREASING ADIPOSE VASCULAR FRACTION - A method and device for processing mammalian adipose tissue such that the vascular rich fraction is separated from the vascular poor fraction, Mammalian adipose tissue in the form of morselated surgical biopsies and/or lipoaspirate from liposuction is placed within a novel syringe attached to a detection device measuring either color, light saturation, infra-red light, heme, iron or oxygen saturation. This process involves no label and minimal manipulation and handling of the tissue. This process and device may also be used intra-operatively under sterile conditions for immediate use within the same individual receiving liposuction or surgery. | 2014-05-29 |
20140147878 | LC-MS SEPARATION AND DETECTION OF VITAMIN D METABOLITES - Systems, kits, and methods for quantitation of metabolites of vitamin D by liquid chromatography-mass spectrometry (LC-MS). The systems, kits, and methods described herein stabilize and/or promote the formation of the protonated molecular ion ([M+H]+) for the vitamin D metabolites in the ionization source (e.g., electrospray ionization (“ESI”)). Formation of the molecular ion does not involve loss of a water molecule from the parent molecule. Subsequent fragmentation of the [M+H]+ ion yields product ions that are specific to each molecular ion. The systems, kits, and methods described herein provide for no compromise in specificity and provide for a significant increase in sensitivity relative to previously described methods. | 2014-05-29 |
20140147879 | CELL CULTURE APPARATUS, APPARATUS FOR LONG-TERM OBSERVATION OF CELL CULTURE, METHOD FOR LONG-TERM CELL CULTURE, AND METHOD FOR LONG-TERM OBSERVATION OF CELL CULTURE - To provide a cell culture apparatus, an apparatus for long-term observation of cell culture, a method for long-term cell culture, and a method for long-term observation of cell culture, which are capable of continuously culturing and observing cells under a uniform environmental condition without variation in physiological state associated with aging of the cultured cells, and also tracing the history (genealogy) of a certain cell. | 2014-05-29 |
20140147880 | ORGAN MIMIC DEVICE WITH MICROCHANNELS AND METHODS OF USE AND MANUFACTURING THEREOF - System and method includes a body having a central microchannel separated by one or more porous membranes. The membranes are configured to divide the central microchannel into a two or more parallel central microchannels, wherein one or more first fluids are applied through the first central microchannel and one or more second fluids are applied through the second or more central microchannels. The surfaces of each porous membrane can be coated with cell adhesive molecules to support the attachment of cells and promote their organization into tissues on the upper and lower surface of the membrane. The pores may be large enough to only permit exchange of gases and small chemicals, or to permit migration and transchannel passage of large proteins and whole living cells. Fluid pressure, flow and channel geometry also may be varied to apply a desired mechanical force to one or both tissue layers. | 2014-05-29 |
20140147881 | MULTIPLE LAMINAR FLOW-BASED PARTICLE AND CELLULAR IDENTIFICATION - The present invention provides a method and apparatus to identify at least one component from a plurality of components in a fluid mixture, the apparatus including a first input channel into which a first flow containing a plurality of components is introduced; a plurality of buffer input channels, into which additional flows of buffer solution are introduced, disposed on either side of the first input channel; wherein the first flow and the additional flows have a flow direction along a length of the apparatus; a detector apparatus which detects and identifies selected components of the plurality of components; a laser which emits a laser beam which damages or kills selected components of the plurality of components; and at least one channel disposed at the another end of the apparatus which is adapted to receive the first flow and the additional flows after operation of the laser on the selected components. | 2014-05-29 |
20140147882 | METHOD AND DEVICE FOR DETECTION AND QUANTIFICATION OF THERMODURIC MICROORGANISMS IN A PRODUCT - Method of detecting the presence of thermoduric microorganisms in a product that includes the steps of (i) placing an aliquot A of a product into a vessel 10 equipped with a probe 30 sensitive to a thermoduric microorganism metabolite, (ii) pasteurizing the aliquot A within the vessel 10, (iii) incubating the pasteurized aliquot A within the vessel 10 for an incubation period, and (iv) periodically interrogating the probe 30 during the incubation period. | 2014-05-29 |
20140147883 | FILTER SUPPORT WITH A PHASE-CHANGING MEDIUM - The present invention relates to a method for processing isolated cells, in particular rare cells such as circulating tumor cells, to render them suitable for optical imaging, comprising the steps of (a) depositing filter material comprising captured cells on a phase-change medium; (b) melting said phase-change medium until the medium is spread out below said filter material; and (c) lowering the temperature of said phase-change medium until the medium solidifies, resulting in an optically flat filter comprising said cells at a fixed position. The method may additionally comprise an initial step of capturing a cell on a filter material. The phase-change medium, preferably paraffin wax, may comprise a porous, or mesh-like structure allowing the passage of a fluid through the medium. The phase-change medium may further be mounted on a carrier such as a glass carrier or a polymer material carrier. The present invention further relates to processed filter material comprising isolated cells suitable for optical imaging, which is obtainable by the method; the use of such filter material for diagnostic, histological, microbiological, biochemical, oncologic, or hematologic analysis, as well as a device for isolating cells or processing cells to render them suitable for optical imaging. | 2014-05-29 |
20140147884 | LASER MICRODISSECTION DEVICE AND METHOD - A laser microdissection device includes a microscope stage for carrying a specimen to be cut, a laser light source for generating a laser beam and a microscope objective for focusing the laser beam onto the specimen. An optical laser scanning device is configured to deflect the laser beam so as to move the laser beam focus in an X-Y direction perpendicular to a main axis of the microscope objective. The laser microdissection device also includes at least one of a Z displacement device configured to move the microscope stage in a Z direction, or an optical focus shifting device configured to move the focus of the laser beam in the Z direction. The Z displacement device and/or optical focus shifting device are controllable, together with the optical laser scanning device, so as to move the laser beam focus in the specimen along a three-dimensional cut line in an X-Y-Z direction. | 2014-05-29 |
20140147885 | PARTICLES CONTAINING ORGANIC CATALYTIC MATERIALS AND USES - Semi-permeable particle can be used to facilitate chemical reactions such as catalytic reactions. The semi-permeable particles are permeable to molecules having a molar mass of 1000 Daltons or less and have a mode particle size of at least 1 μm. The semi-permeable particles have multiple discrete cavities containing an aqueous solution or suspension of an organic catalytic material. The semi-permeable particles are also impermeable to the organic catalytic materials so they are retained within the multiple discrete cavities, and the semi-permeable particles can be reused multiple times for the same or different chemical reaction. | 2014-05-29 |
20140147886 | METHOD TO INCREASE THE YIELD OF PRODUCTS IN PLANT MATERIAL - A method to increase the production of products of interest in plant material including plant cultures, such as, for example, cell suspension cultures, root cultures, and hairy root cultures is provided. In one embodiment, the method is to contacting the plant material with a precursor or xenobiotic when producing a product of interest from a plant. In another embodiment the plant material is also contacted with a trapping agent. The process may also provide for contacting an elicitor of the product of interest with the plant material. An embodiment provides for contacting an elicitor, precursor and trapping agent with the plant material. The ability to produce novel compounds such as glucosides and glucuronides is provided. | 2014-05-29 |
20140147887 | NOVEL 12 ALPHA-HYDROXYSTEROID DEHYDROGENASES, PRODUCTION AND USE THEREOF - The invention provides 12α-hydroxysteroid dehydrogenases, nucleic acid sequences coding for the same, expression cassettes and vectors, recombinant microorganisms containing the corresponding coding nucleic acid sequences, methods for producing said 12α-hydroxysteroid dehydrogenases, methods for enzymatic oxidation of 12α-hydroxysteroids using said enzyme, methods for enzymatic reduction of 12-ketosteroids using said enzyme, methods for qualitative or quantitative determination of 12-ketosteroids and/or 12α-hydroxysteroids using said 12α-hydroxysteroid dehydrogenases and methods for production of ursodesoxycholic acid, comprising the enzyme-catalysed cholic acid oxidation using said 12α-hydroxysteroid dehydrogenases. | 2014-05-29 |
20140147888 | Method for Producing a Polypeptide in Yarrowia Lipolytica - This invention relates to a method for the production of proteins, preferably, heterologous proteins, under the regulation of the hp4d promoter, in | 2014-05-29 |
20140147889 | PROMOTER OF CORYNEBACTERIA - An isolated nucleic acid comprising a promoter region having a nucleotide sequence of SEQ ID NO: 1, which can maintain high expression under aerobic and anaerobic conditions, and related compositions and methods. | 2014-05-29 |
20140147890 | GENETICALLY MODIFIED PHAGE AND USE THEREOF - The present invention relates to a genetically modified phage and use thereof in a method for producing a bio molecule of interest. | 2014-05-29 |
20140147891 | MUTANT ENDOGLYCOCERAMIDASES WITH ENHANCED SYNTHETIC ACTIVITY - The present invention relates to a novel endoglycoceramidase whose hydrolytic activity has been substantially reduced or eliminated, such that the enzyme is useful for synthesis of glycolipids from a monosaccharide or oligosaccharide and a ceramide. More specifically, the endoglycoceramidase is a mutant version of a naturally occurring endoglycoceramidase, preferably comprising a mutation within the active site or the nucleophilic site of the enzyme and more preferably comprising a substitution mutation of the Glu residue within the active site or the nucleophilic site. Also disclosed are a method for generating the mutant endoglycoceramidase and a method for enzymatically synthesizing glycolipids using this mutant enzyme. | 2014-05-29 |
20140147892 | METHOD AND MATERIALS FOR ISOLATION OF NUCLEIC ACID MATERIALS - A method for nucleic acid isolation comprising: receiving a binding moiety solution within a process chamber; mixing the binding moiety solution with a biological sample, within the process chamber, in order to produce a moiety-sample mixture; incubating the moiety-sample mixture during a time window, thereby producing a solution comprising a set of moiety-bound nucleic acid particles and a waste volume; separating the set of moiety-bound nucleic acid particles from the waste volume; washing the set of moiety-bound nucleic acid particles; and releasing a nucleic acid sample from the set of moiety-bound nucleic acid particles. The method preferably utilizes a binding moiety comprising at least one of poly(allylamine) and polypropylenimine tetramine dendrimer, both of which reversibly bind and unbind to nucleic acids based upon environmental pH. | 2014-05-29 |
20140147893 | ALPHA AMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME - The present invention relates to variants of alpha amylase. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants. | 2014-05-29 |
20140147894 | VARIANT CBH I POLYPEPTIDES WITH REDUCED PRODUCT INHIBITION - The present disclosure relates to variant CBH I polypeptides that have reduced product inhibition, and compositions, e.g., cellulase compositions, comprising variant CBH I polypeptides. The variant CBH I polypeptides and related compositions can be used in variety of agricultural and industrial applications. The present disclosure further relates to nucleic acids encoding variant CBH I polypeptides and host cells that recombinantly express the variant CBH I polypeptides. | 2014-05-29 |
20140147895 | Processes for Pretreating Cellulosic Material and Improving Hydrolysis Thereof - The present invention relates to processes for pre-treating cellulosic material and processes for improving hydrolysis thereof. In particular, cellulosic material such as woody biomass is contacted with one or more enzymes in a re-pulping step. The cellulosic material is then contacted with one or more enzymes to improve hydrolysis of the cellulosic material. The hydrolysis is also enzymatically enhanced by use of an amylase and/or mannanase. | 2014-05-29 |
20140147896 | ENZYME FOR THE PRODUCTION OF OPTICALLY PURE 3-QUINUCLIDINOL - The present invention provides a process for production of optically pure quinuclidinol of formula-(I) by reduction of quinuclidinone of formula-(II) in presence of suitable oxidoreductase enzyme derived from | 2014-05-29 |
20140147897 | TWO STAGE HIGH SPEED CENTRIFUGES IN SERIES USED TO RECOVER OIL AND PROTEIN FROM A WHOLE STILLAGE IN A DRY MILL PROCESS - Methods of and devices for recovering oil and protein and increasing production yields using two centrifuges in series or a centrifuge with dual oil and protein separating functions in a dry mill are provided. | 2014-05-29 |
20140147898 | Separation Process - A process for treating a mixture of R,R- and S,S-lactide is provided. The process involves contacting the mixture with an aliphatic alcohol and an enzyme to produce a mixture comprising aliphatic ester of lactic acid corresponding to one lactide enantiomer and the aliphatic ester of lactyllactic acid corresponding to the other lactide enantiomer; separating the mixture from the enzyme, and recycling the enzyme to the process; and separating the aliphatic ester of lactic acid from the aliphatic ester of lactyl-lactic acid by fractional distillation. Also provided are processes for the production of S-lactic acid, S,S-lactide, poly-S-lactic acid, R-lactic acid, R,R-lactide, poly-R-lactic acid and stereocomplex polylactic acid. | 2014-05-29 |
20140147899 | VARIANT SUCROSE TRANSPORTER POLYPEPTIDES - Variant sucrose transporter polypeptides that enable bacterial growth over a wide range of gene expression levels and sucrose concentrations are described. Additionally, recombinant bacteria comprising these variant sucrose transporter polypeptides, and methods of utilizing the bacteria to produce products such as glycerol and glycerol-derived products are provided | 2014-05-29 |
20140147900 | MICROORGANISMS AND METHODS FOR CONVERSION OF SYNGAS AND OTHER CARBON SOURCES TO USEFUL PRODUCTS - A non-naturally occurring microbial organism having an isopropanol, 4-hydroxybutryate, or 1,4-butanediol pathway includes at least one exogenous nucleic acid encoding an isopropanol, 4-hydroxybutryate, or 1,4-butanediol pathway enzyme expressed in a sufficient amount to produce isopropanol, 4-hydroxybutryate, or 1,4-butanediol. The aforementioned organisms are cultured to produce isopropanol, 4-hydroxybutryate, or 1,4-butanediol. | 2014-05-29 |
20140147901 | IMMOBILIZED PRODUCT TOLERANT MICROORGANISMS - Methods for adapting or selecting microorganisms with increased product tolerance are provided. Additionally, a bioreactor capable of operation in either packed bed or fluidized bed is disclosed along with methods to use the bioreactor for culturing microorganisms adapted or selected increased product tolerance. | 2014-05-29 |
20140147902 | COMPOSITIONS AND METHODS FOR IMPROVED ISOPRENE PRODUCTION USING TWO TYPES OF ISPG ENZYMES - The invention provides for compositions and methods for producing isoprene by using recombinantly engineered cells that utilize a system of dual IspG enzymes in addition to isoprene synthase. | 2014-05-29 |
20140147903 | Process for the Preparation of Amoebocyte Lysate from Haemolymph of the Horseshoe Crab - The present invention relates to a non-destructive process for the preparation of amoebocyte lysate from the haemolymph of horseshoe crab, characterized by the steps of firstly, means for acclimatizing a live specimen of horseshoe crab in treated seawater under controlled conditions; then, means for cleaning the live specimen, including cleaning the base of the last pair of thoracic appendages of the live specimen; next, means for withdrawing the haemolymph through the base of the last pair of thoracic appendage under aseptic condition; then, means for transferring the collected haemolymph into a pre-cooled disposable centrifuge tube; then, means for centrifuging the collected haemolymph to separate amoebocyte cells from lymph; then, means for decanting the lymph out of the disposable centrifuge tube; then, means for washing the white amoebocyte cells and centrifuging; then, means for sonicating the amoebocyte cells for lysing of the amoebocyte cells; then, means for storing the sonicated amoebocyte cells for further lysing of the amoebocyte cells; then, means for centrifuging the sonicated mixture, thereby separating the amoebocyte lysate in the form of a supernatant; then, means for decanting the amoebocyte lysate into a sterilized vessel; then, means for pre-freezing the amoebocyte lysate; and subsequently, freeze-drying the amoebocyte lysate. | 2014-05-29 |
20140147904 | FILTERING APPARATUS AND METHOD FOR MIXING, EXTRACTION AND/OR SEPARATION - The present invention relates to a filtering apparatus and method for mixing a compound of solid and fluid phases, separating the phases and/or extracting fluid from the compound. One embodiment of the invention discloses a filtering apparatus comprising a first filter section accommodating a first group of filter members, and a second filter section accommodating a second group of filter members, a piping system providing pipelined fluid communication between the filter sections and between a filter section and said filter section's corresponding group of filter members, the piping system configured such that the filter members form filtered fluid openings of the filtering apparatus, and circulation means, such as a pump, configured for passing fluid in a forward flow and/or in a reverse flow between the filter sections. In particular the invention may be used for the mashing process in a beer brewing procedure. | 2014-05-29 |
20140147905 | Boronic and Borinic Acid Compounds as Inhibitors of Sulfenic Acid-Containing Proteins - A boronic or borinic acid compound is used to inhibit the activity of a sulfenic acid-containing protein. Thus, a biologically-active sulfenic acid-containing protein is contacted with an activity-inhibiting effective amount of a boronic or borinic acid compound of Formula I or a salt, hydrate or solvate thereof, whose components are disclosed within, and that contact is maintained for a time sufficient to inhibit the biological activity of the protein. | 2014-05-29 |
20140147906 | ANTIBODY CONJUGATES - Antibody/signal-generating moiety conjugates are disclosed that include an antibody covalently linked to a signal-generating moiety through a heterobifunctional polyalkyleneglycol linker. The disclosed conjugates show exceptional signal-generation in immunohistochemical and in situ hybridization assays on tissue sections and cytology samples. In one embodiment, enzyme-metallographic detection of nucleic acid sequences with hapten-labeled probes can be accomplished using the disclosed conjugates as a primary antibody without amplification. | 2014-05-29 |
20140147907 | PROCESSING BIOMASS - Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems can use feedstock materials, such as cellulosic and/or lignocellulosic materials, to proceed ethanol and/or butanol, e.g., by fermentation. | 2014-05-29 |
20140147908 | METHOD FOR SPLITTING DROPLETS ON DEMAND IN MICROFLUIDIC JUNCTION - The invention relates to a method for splitting droplets on demand in a microfluidic junction, comprising the supply channel, the first drain channel and the second drain channel, the method comprises the following steps:
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20140147909 | Method for Producing an L-Amino Acid Using a Bacterium of the Enterobacteriaceae Family - The present invention provides a method for producing an L-amino acid from ethanol using a bacterium of the | 2014-05-29 |
20140147910 | METHODS AND SYSTEMS FOR RECOVERING PHOSPHORUS FROM WASTEWATER WITH ENHANCED REMOVAL OF PHOSPHORUS FROM BIOSOLIDS - Methods and systems for removal and recovery of phosphorus from wastewater and producing inorganic phosphorus complexes with enhanced removal of phosphorus from biosolids. | 2014-05-29 |
20140147911 | PREFABRICATED MULTI-MODAL BIOENERGY SYSTEMS AND METHODS - A prefabricated, multi-modal, bio-mimicry system that can be quickly deployed. | 2014-05-29 |
20140147912 | BIO-SENSOR - A bio-sensor configured with a lower substrate including a plurality of electrode portions, an insulating layer, a spacer layer, and an upper substrate provided on the spacer layer is provided. The bio-sensor includes a first sample injection portion provided between the upper substrate and the lower substrate along a longitudinal direction in which a sample is introduced and a second sample injection portion that is connected with the first sample injection portion in a direction substantially longitudinal direction, and formed larger than a sample inlet of the first sample injection portion. | 2014-05-29 |
20140147913 | Test Element Analysis System with Contact Surfaces Coated with Hard Material - The invention concerns a test element analytical system for the analytical examination of a sample, especially a body fluid, comprising at least one test element with one or more measuring zones and contact areas located on the test element, in particular electrodes or conductor paths, the sample to be examined being brought into the measuring zone to carry out an analysis in order to determine a characteristic measured quantity for the analysis, and an evaluation instrument with a test element holder for positioning the test element in a measuring position and a measuring device for measuring the characteristic change, the test element holder containing contact elements with contact areas which enable an electrical contact between the contact areas of the test element and the contact areas of the test element holder, characterized in that one of these contact areas is provided with an electrically conductive hard material surface. | 2014-05-29 |
20140147914 | BIOTIP - A biotip according to an embodiment of the invention moves a reaction mixture along a longitudinal direction under the force of gravity. The biotip includes a chamber formed of a transparent material and filled with a liquid having a smaller specific gravity than the reaction mixture and immiscible with the reaction mixture, and a seal that seals the chamber. The liquid has a volume resistivity of greater than 0 Ω·cm and 5×10 | 2014-05-29 |
20140147915 | CULTURE DEVICE - The culture device ( | 2014-05-29 |
20140147916 | CELL CRYOPRESERVATION CONTAINER - Provided is a cell cryopreservation container which is provided with a plurality of storage chambers and enables efficient storage of cells in a definite capacity. The cell cryopreservation container ( | 2014-05-29 |
20140147917 | REIC-EXPRESSING ADENOVIRUS VECTOR - An objective of the present invention is to provide an adenovirus vector expressing a REIC/Dkk-3 protein at a high level and containing a DNA construct for expression of REIC/Dkk-3 DNA, wherein the DNA construct is prepared by ligating, from the 5′ terminal side,
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20140147918 | MICRO AND NANO GLASS BALLS EMBEDDED IN A GEL PRESENTING MICROMETER AND NANOMETER SCALE CURVATURE AND STIFFNESS PATTERNS FOR USE IN CELL AND TISSUE CULTURING AND A METHOD FOR MAKING SAME - A substrate for use in culturing cells or tissues. The substrate comprises a gel, one or more microstructures partially embedded within a surface of the gel, the one or more microstructures presenting two different curvatures or presenting two different stiffness values or presenting a combination of different curvatures and different stiffness values, wherein the microstructures are disposed at defined locations within the surface of the gel, and wherein the cells and tissues are cultured on an exposed surface of the microstructures. | 2014-05-29 |
20140147919 | HOMOZYGOUS AND HETEROZYGOUS IDH1 GENE-DEFECTIVE CELL LINES DERIVED FROM HUMAN COLORECTAL CELLS - IDH1 gene-defective cell lines (e.g., IDH1R132H heterozygous) have been made from a robust cell line, HCT116. The IDH1 gene-defective cell lines can be used to determine the effect of IDH1R132H on cell biology, tumorigenesis, and cellular metabolic profiles. These cell lines can be used to test potential therapeutic targets and to screen potential therapeutic agents. Kits and xenografts are also contemplated. | 2014-05-29 |
20140147920 | Specific nNOS Inhibitors for the Therapy and Prevention of Human Melanoma - Methods for melanoma treatment and prevention with selective nitric oxide synthase inhibitor compounds and related pharmaceutical compositions, alone or in conjunction with one or more other melanoma therapies. | 2014-05-29 |
20140147921 | MICROSECOND TIME-RESOLVED MASS SPECTROMETRY - A microsecond time-resolved mass spectrometry device and method of using desorption electrospray ionization ( | 2014-05-29 |
20140147922 | Device for Positioning Vessels and Utilization of a Device for Positioning Vessels - A device for positioning vessels, with | 2014-05-29 |
20140147923 | METHODS AND DEVICES FOR TESTING WATER - Methods and systems for testing fluid samples include a diffused air flotation (DAF) system and a jar. The jar includes a diffuser for injecting the diffused air into the jar and a tap for drawing a fluid out of the jar. | 2014-05-29 |
20140147924 | Apparatus and Method for the Remote Sensing of Blood in Human Feces and Urine - The apparatus and method for detecting blood in urine or feces includes a photodetector configured to detect a transient light emitted in a toilet bowl by luminol and an oxidizer catalyzed by iron in the blood. The apparatus may include dispensers for the luminol, the oxidizer and a base. The apparatus may include a microprocessor and a network connection and may perform statistical analyses, store data and alert the patient or a healthcare provider if blood is detected. The photodetector may be configured to detect light emitted in the toilet bowl by a fluorophore present in the water and excited by the transient light from the luminol and oxidizer. | 2014-05-29 |
20140147925 | Method for Profiling Phytohormone Levels in Plant Tissue - The present invention provides a method for profiling phytohormone levels in plant tissue or tissue of other plastid containing organisms, i.e. a method for the simultaneous determination of a multitude of phytohormone levels in plant tissue or tissue of other plastid containing organisms, which method comprises the following steps:
| 2014-05-29 |
20140147926 | METHOD OF ANALYZING ALDEHYDE COMPOUND IN METAL PLATING SOLUTION - This invention relates to a method of analyzing an aldehyde compound in a metal plating solution, including adding a pH control solution to an aldehyde derivative, thus preparing an oversaturated aldehyde derivative solution in which the aldehyde derivative is dissolved to be oversaturated while the pH of the aldehyde derivative solution is adjusted to be the same as that of the metal plating solution; adding the oversaturated aldehyde derivative solution to the metal plating solution, so that the aldehyde compound which is present in the metal plating solution undergoes derivation, thus obtaining an aldehyde derivative compound; extracting the aldehyde derivative compound; and analyzing the aldehyde compound from the extracted aldehyde derivative compound. | 2014-05-29 |