23rd week of 2014 patent applcation highlights part 52 |
Patent application number | Title | Published |
20140155258 | PROCESS FOR THE CONVERSION OF ETHANE TO AROMATIC HYDROCARBONS - A process for producing aromatic hydrocarbons which comprises (a) contacting ethane with a dehydroaromatization aromatic catalyst which is comprised of 0.005 to 0.1% wt platinum, an amount of iron which is equal to or greater than the amount of the platinum, from 10 to 99.9% wt of an aluminosilicate, and a binder, and (b) separating methane, hydrogen, and C | 2014-06-05 |
20140155259 | SUPERABSORBENT POLYMER HAVING A CAPACITY INCREASE - The present invention relates to a particulate superabsorbent polymer comprising a monomer and an internal crosslinker agent wherein the particulate superabsorbent polymer has a Centrifuge Retention Capacity Increase of 2 g/g or more as set forth herein in the Centrifuge Retention Capacity Increase Test. The present invention further relates to a superabsorbent polymer comprising an internal crosslinker agent comprising a silane compound comprising at least one vinyl group or one allyl group attached to a silicon atom, and at least one Si—O bond. The present invention further relates to an absorbent article that includes such particulate superabsorbent polymers. | 2014-06-05 |
20140155260 | COMPOSITION AND PROCESS FOR MERCURY REMOVAL - A process for removing mercury from a gas or liquid phase, wherein the gas or liquid phase containing mercury is placed in contact with a composition comprising a precipitated metal sulfide. The precipitated metal sulfide may be made by the process of combining a metal source, sulfide source, and modifier to form the precipitated metal sulfide. The metal source may comprise iron, cobalt, nickel, copper, zinc, zirconium, molybdenum, silver, or gold salts. The metal salt may be selected from metal nitrate, metal sulfate, metal phosphate, metal acetate, metal carbonate, metal hydroxide, metal ammonium carbonate, and metal hydroxycarbonate. The sulfide source is selected from hydrogen sulfide (H | 2014-06-05 |
20140155261 | Honeybee Repellents and Uses Thereof - The present specification discloses honeybee repellents exhibiting repellent properties similar to 2-heptanone, compositions comprising such repellents, uses to repel a honeybee from a mammal, location, plant, structure treated of such repellents, and methods of treating a mammal, location, plant, structure by applying such repellents. | 2014-06-05 |
20140155262 | Fungicidal substituted 2-[2-halogenalkyl-4-(phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds - The present invention relates to substituted 2-[2-halogenalkyl-4-(phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds of formula I as defined in the description, and the N-oxides, and salts thereof, their preparation and intermediates for preparing them. The invention also relates to the use of these compounds for combating harmful fungi and seed coated with at least one such compound and also to compositions comprising at least one such compound. | 2014-06-05 |
20140155263 | Fungicidal Mixtures Based on Azolopyrimidinylamines - Fungicidal mixtures comprising, as active components,
| 2014-06-05 |
20140155264 | N-Thio-Anthranilamide Compounds and Their Use as Pesticides - The present invention relates to N-thio-anthranilamide compounds of the formula (I), the stereoisomers, the salts, the tautomers and the N-oxides thereof, | 2014-06-05 |
20140155265 | HERBICIDAL COMPOSITIN COMPRISING PINOXADEN AND FLUROXYPYR AND METHODS OF USE THEREOF - The invention provides a liquid herbicidal composition in the form of an emulsifiable concentrate, comprising a mixture of: (i) pinoxaden; (ii) a C | 2014-06-05 |
20140155266 | POTENTIATOR FOR SOLUBLE LIQUID HERBICIDE - An emulsion composition for use as potentiator in a soluble liquid herbicide formulation comprising a natural oil-based ester, a hydrophilic surfactant, a lipophilic surfactant, a natural oil-based ethanol amide co-surfactant and a natural oil-based glyceride ethoxylate co-surfactant. | 2014-06-05 |
20140155267 | THERMOPLASTIC PASTE FOR REPAIRING LIVING TISSUES - This invention relates to a thermoplastic paste with a highly thixotropic rheology, the components of which are a block biopolymer and a bioceramic. The material described herein can be used in bone implants and in the regeneration of both animal and plant live tissues. | 2014-06-05 |
20140155268 | SYSTEM AND APPARATUS FOR COMPENSATING FOR MAGNETIC FIELD DISTORTION IN AN MRI SYSTEM - A magnet apparatus for a magnetic resonance imaging system, the magnet apparatus includes a cylindrical vacuum vessel, a closed loop cooling system disposed within the vacuum vessel and a cylindrical thermal shield disposed between the vacuum vessel and the closed loop cooling system. A set of passive compensation coils are disposed within the vacuum vessel and used to compensate for magnetic field distortion caused by mechanical vibrations within the magnet apparatus. | 2014-06-05 |
20140155269 | OXIDE SUPERCONDUCTOR WIRE AND SUPERCONDUCTING COIL - An oxide superconductor wire includes: a superconductor laminate that comprises a substrate which is formed in a tape shape and an intermediate layer, an oxide superconductor layer, and a metal stabilizing layer which are laminated on the substrate; and an insulating coating layer that covers an outside surface of the superconductor laminate, Also, either the entire outside surface or the entire inside surface of the insulating coating layer is coated with a coating layer formed of a fluororesin. | 2014-06-05 |
20140155270 | NbTi superconductor with reduced weight - A superconducting wire ( | 2014-06-05 |
20140155271 | METHODS AND COMPOSITIONS FOR DIAGNOSING, PROGNOSING, AND TREATING NEUROLOGICAL CONDITIONS - This document provides methods and materials related to genetic variations of neurological disorders. For example, this document provides methods for using such genetic variations to assess susceptibility of developing Parkinson's disease. | 2014-06-05 |
20140155272 | Use Of Diatomaceous Earth As The Base Substrate For Nucleic Acid Tags - A nucleic acid tag comprising: a nanoparticle nucleotide-support platform attached to a plurality of nucleic acid molecules, each of said nucleic acid molecules comprising identifying information, with a spacer located between the nanoparticle nucleotide-support platform and the identifying information, and where the nanoparticle nucleotide-support platform comprises diatomaceous earth; and an encapsulant surrounding the nanoparticle nucleotide-support platform. | 2014-06-05 |
20140155273 | Method for Detecting the Genus of Bacillus in Samples from Oil Reservoirs - The invention provides a quick method for detecting the genus of | 2014-06-05 |
20140155274 | Single Cell Nucleic Acid Detection and Analysis - Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided. | 2014-06-05 |
20140155275 | SEMI-DIGITAL LIGATION ASSAY - Assays for detecting mutant sequences at particular locations, especially against a background of non-mutant sequences, employ thermocycling ligase reactions. Differentially labeled or sized probes can be used to distinguish wild-type and mutant sequences. Physico-chemical properties of the probes can be critical to successful detection. Mutation detection can be used for diagnosis, monitoring, or prognosticating diseases such as cancers. | 2014-06-05 |
20140155276 | ISOLATION OF POLYMERASE-NUCLEIC ACID COMPLEXES - Compositions, methods and systems are provided for the isolation of polymerase-nucleic acid complexes. Complexes can be separated from free enzyme by using hook molecules to target single stranded regions on the nucleic acid. Hook oligonucleotides are used to capture polymerase nucleic acid complexes where the nucleic acids comprise circular nucleic acids having a double stranded central region with hairpin regions on each end. Methods for loading such complexes onto substrates and for single molecule sequencing of such complexes are also provided. | 2014-06-05 |
20140155277 | Adaptive Immunity Profiling and Methods for Generation of Monoclonal Antibodies - Methods are provided for producing monoclonal antibody candidates using adaptive immunity profiling. In some aspects, the method provides for the use of massively parallel signature sequencing. | 2014-06-05 |
20140155278 | SYSTEM AND METHOD FOR DETECTING BIOLOGICAL MATERIALS - A method of identifying a target biological material by using captures and probes. Each capture is specific for a kind of target. Each probe is designed to distinguish the type of the target. The captures and probes are each labeled with one or more detectable labels. | 2014-06-05 |
20140155279 | Detection of a panel of urine DNA markers for HCC screening and disease management - Provided herein is a method for detecting the presence or absence of a cancer in a biological sample of an individual, by determining the level of mutation and methylation of one or more genes from a group of genes comprising TP53, CTNNB1, hTERT, RASSF1A, GSTP1, p16, p15 and SFRP-1. Also provided herein is an assay to detect p53 mutations suitable for DNA isolated from biological body fluid in order to screen cancer patients. | 2014-06-05 |
20140155280 | METHOD OF DIAGNOSING NEOPLASMS - The present invention relates generally to a method for screening a subject for the onset, predisposition to the onset and/or progression of a colorectal neoplasm by screening for modulation in the level of expression of one or more nucleic acid markers. More particularly, the present invention provides a method for screening a subject for the onset, predisposition to the onset and/or progression of a colorectal neoplasm by screening for modulation in the level of expression of one or more gene markers in membranous microvesicles. The expression profiles of the present invention are useful in a range of applications including, but not limited to, those relating to the diagnosing and/or monitoring of colorectal neoplasms, such as colorectal adenoma and adenocarcinomas. | 2014-06-05 |
20140155281 | Method of assessing infection status - The present invention relates to a method for assessing the infection status of a subject and in particular to a method for assessing the infection status of a subject by analysing the cellular and/or humoral composition of breastmilk from said subject. The invention has been developed primarily for use as a method for detecting infection in a breastfeeding mother and/or infant. | 2014-06-05 |
20140155282 | METHODS OF DETERMINING STABILIZATION COMPOUNDS FOR PREDICTIVE BIOMARKERS - Methods of determining stabilization compounds for predictive biomarkers. According to at least one embodiment of a method of the present disclosure, the method comprises introducing a diagnostic marker and a stabilization agent to a detection platform, mixing the diagnostic marker and stabilization agent, and determining their binding characteristics. Additionally, the method may further comprise generating a report based on the binding characteristics and delivering the report to a recipient. | 2014-06-05 |
20140155283 | MICROARRAY FOR DETECTING VIABLE ORGANISMS - A methodology of microarray using the fluorescent DNA intercalating agent propidium monoazide (PMA) to selectively block DNA of dead cells from amplification and its application in detecting and enumerating viable microbes in complex microbial communities is described. A phylogenetic array is used in the preferred embodiment to enhance the sensitivity of the method. The PMA-Microarray assay is particularly applicable for monitoring samples from environments with extremely low microbial burden such as spacecraft surfaces. | 2014-06-05 |
20140155284 | SYSTEM FOR IDENTIFICATION OF MICROORGANISM AND DETECTION OF INFECTIOUS DISEASE - Methods for the identification of microorganisms or infectious disorders are disclosed, comprising obtaining a suitable sample from sources such as persons, animals, plants, food, water or soil. The methods also comprise providing tailored nucleic acid substrate(s) designed to react with a type 1 topoisomerase from one or more microorganism(s) or infectious agent(s), and incubating said substrate with said sample, or extracts or preparations from the sample, so that the substrate is processed by said topoisomerase if said microorganism(s) or infectious agent(s) is present in the sample. Microfluidic-implemented methods of detecting an enzyme, in particular a DNA-modifying enzyme, are also provided, as well as methods for detecting a cell, or a microorganism expressing said enzyme. The enzyme is detected by providing a nucleic acid substrate, which is specifically targeted by that enzyme. | 2014-06-05 |
20140155285 | NOVEL CELL LINE SCREENING METHOD - The invention provides a novel cell line development method useful to screen for recombinant protein production. The method utilizes a membrane-anchored reporter or an intracellular reporter residing in the expression vector for a gene of interest to facilitate initial cell selection by FACS or MACS. A switching mechanism can be used to delete the reporter from the chromosome by providing an appropriate DNA recombinase, which turns the selected cells into production cells that secrete the protein of interest without co-expression of the reporter. | 2014-06-05 |
20140155286 | MODIFIED TYROSINE AMINO ACIDS, PEPTIDES CONTAINING THEM, AND THEIR USE FOR DETECTING HYDROLASE ENZYME ACTIVITY - The present invention relates to a method and tools which allow the kinetic monitoring of hydrolase enzyme activity. The present invention also aims to provide synthetic peptides and peptide residues modified such that they can be used in assays for monitoring hydrolase enzyme activity, and preferably phosphatase activity. Also claimed are modified tyrosine amino acid derivatives of formula (IV), wherein Y is chosen from —PO | 2014-06-05 |
20140155287 | METHODS AND COMPOSITIONS FOR ASSESSMENT OF PULMONARY FUNCTION AND DISORDERS - The present invention provides methods for the assessment of risk of developing lung cancer in smokers and non-smokers using analysis of genetic polymorphisms. The present invention also relates to the use of genetic polymorphisms in assessing a subject's risk of developing lung cancer, and the suitability of a subject for an intervention in respect of lung cancer. Nucleotide probes and primers, kits, and microarrays suitable for such assessment are also provided. | 2014-06-05 |
20140155288 | METHODS FOR DIAGNOSING CANCER - The invention provides cDNAs which encodes a signal peptide-containing proteins. It also provides for the use of a cDNA, protein, and antibody in the diagnosis, prognosis, treatment and evaluation of therapies for cancer. The invention further provides vectors and host cells for the production of the protein and transgenic model systems. | 2014-06-05 |
20140155289 | NUCLEIC ACID ANALYSIS METHOD - Embodiments relate to a method of analyzing nucleic acid. The nucleic acid analysis method includes subjecting a sample to an amplifying reaction using first and second primers, reacting an amplification product with a nucleic acid probe, measuring presence/absence of hybridization and/or a quantity thereof, and determining presence/absence of a target nucleic acid in the sample and/or a quantity of target nucleic acid. The amplification product obtained with the first or second primer forms a stem-and-loop structural body. With the detection of the presence/absence of the hybridization between a nucleic acid probe for the loop structure and the amplification product, and/or the amount thereof, the nucleic acid analysis is carried out on the sample. | 2014-06-05 |
20140155290 | HOST CELLS COMPRISING ALPHA 1, 2 MANNOSIDASE AND CULTURE METHODS THEREOF - Improved host cells and culture methods involving overexpression of MAN1C1 activity to improve protein production are provided. | 2014-06-05 |
20140155291 | Method for Identifying Lineage-Related Antibodies - In certain embodiments, the method may comprise: a) obtaining the antibody sequences from a population of B cells; b) grouping the antibody sequences to provide a plurality of groups of lineage-related antibodies; c) testing a single antibody from each of the groups in a bioassay and, after the first antibody has been identified, d) testing further antibodies that are in the same group as the first antibody in a second bioassay. In another embodiment, the method may comprise: a) testing a plurality of antibodies obtained from a first portion of an antibody producing organ of an animal; b) obtaining the sequence of a first identified antibody; c) obtaining from a second portion of said antibody producing organ the sequences of further antibodies that are related by lineage to said first antibody; and, c) testing the further antibodies in a second bioassay. | 2014-06-05 |
20140155292 | METHODS OF MONITORING ANGIOGENESIS AND METASTASIS IN THREE DIMENSIONAL CO-CULTURES - This disclosure relates to fluorescent cell lines and to the use of such cell lines in monitoring cellular activity, such as angiogenesis. This disclosure further relates to the use of such cell lines in a three-dimensional cell culture to monitor angiogenic and metastatic potential of tumor cells and selecting personalized therapeutics for treatment of cancer. | 2014-06-05 |
20140155293 | IDENTIFICATION OF BIOMARKERS FOR DETECTING PROSTATE CANCER - The present invention relates to a method of qualifying prostate cancer status in a subject comprising: (a) measuring at least one of the disclosed biomarkers in a sample from the subject and (b) correlating the measurement with prostate cancer status. The invention further relates to kits for qualifying prostate cancer status in a subject. | 2014-06-05 |
20140155294 | CELL CHIP, CELL SLICE SAMPLE AND MANUFACTURING METHOD THEREOF - There is provided a cell chip, a cell slice sample, and a manufacturing method thereof. The cell chip includes a plate member; biomaterials attached to one surface of the plate member; and a solidifiable material formed on one surface of the plate member to form a layer including the biomaterials. | 2014-06-05 |
20140155295 | CAPSULE ARRAY DEVICES AND METHODS OF USE - This disclosure provides microwell capsule array devices. The microwell capsule array devices are generally capable of performing one or more sample preparation operations. Such sample preparation operations may be used as a prelude to one more or more analysis operations. For example, a device of this disclosure can achieve physical partitioning and discrete mixing of samples with unique molecular identifiers within a single unit in preparation for various analysis operations. The device may be useful in a variety of applications and most notably nucleic-acid-based sequencing, detection and quantification of gene expression and single-cell analysis. | 2014-06-05 |
20140155296 | METHODS AND COMPOSITIONS FOR IMPROVED CATTLE LONGEVITY AND MILK PRODUCTION - A single nucleotide polymorphic site at position 10793 of the bovine POU1F1 gene is associated with improved longevity and milk product traits. Disclosed are nucleic acid molecules, kits, methods of genotyping and marker assisted bovine breeding methods. | 2014-06-05 |
20140155297 | METHOD AND APPARATUS FOR LIGHT BASED RECOVERY OF SEQUENCE VERIFIED DNA - A method of retrieving sequence-verified deoxyribonucleic acid (DNA) from a DNA sequencing plate includes directing a laser beam to impinge on a predetermined area on the DNA sequencing plate. The DNA sequencing plate contains a plurality of sequence-verified DNA disposed thereon. The method also includes exposing the predetermined area to a radiation dosage provided by the laser beam to generate at least one of an optical pressure or an ablating force in the predetermined area. The optical pressure or ablating force result in the ejection of at least one sequence-verified DNA disposed proximate to the predetermined area. | 2014-06-05 |
20140155298 | MOLECULAR PROFILING OF TUMORS - Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. | 2014-06-05 |
20140155299 | USE OF OLIGO-QUATERNARY COMPOSITIONS TO INCREASE SCALE INHIBITOR LIFETIME IN A SUBTERRANEAN FORMATION - A method of inhibiting scale in a subterranean formation comprises pretreating the subterranean formation with a polyquaternary amine that serves as a squeeze life extention (SLE) agent, and then introducing a scale inhibitor pill into the subterranean formation, wherein the scale inhibitor pill includes one or more scale inhibitor compositions. For example, the polyquaternary amine may be a polymer having up to 5 quaternary amine centers, but is preferably a nonpolymeric diquaternary amine having a molecular weight of from 250 to 500. One such example is 1,3-propandiaminium, 2-hydroxy-N,N,N,N′,N′,N′-hexamethyl-, dichloride. The SLE agent is preferably introduced into the formation in a brine solution having a concentration from 0.1 to 20 weight percent. The SLE agents may be used with a variety of known scale inhibitors and scale inhibitor chemistries. | 2014-06-05 |
20140155300 | OIL OR GAS TREATMENT FLUID CONTAINING A CHELATE OR COORDINATION COMPLEX THAT SETS - A treatment fluid comprises: a metal oxide, wherein the metal oxide is capable of forming a chelate complex or coordination complex with a ligand, wherein the chelate complex or coordination complex has a setting time of less than 90 minutes at a temperature of 71° F. and a pressure of 1 atmosphere. A method of treating a portion of a subterranean formation comprises: introducing the treatment fluid into the subterranean formation; allowing or causing a chelate complex or coordination complex to form between the metal oxide and a ligand; and allowing or causing the chelate complex or coordination complex to set. | 2014-06-05 |
20140155301 | PROCESSES AND APPARATUS FOR PRODUCING NANOCELLULOSE, AND COMPOSITIONS AND PRODUCTS PRODUCED THEREFROM - Processes disclosed are capable of converting biomass into high-crystallinity nanocellulose with surprisingly low mechanical energy input. In some variations, the process includes fractionating biomass with an acid (such as sulfur dioxide), a solvent (such as ethanol), and water, to generate cellulose-rich solids and a liquid containing hemicellulose and lignin; and mechanically treating the cellulose-rich solids to form nanofibrils and/or nanocrystals. The total mechanical energy may be less than 500 kilowatt-hours per ton. The crystallinity of the nanocellulose material may be 80% or higher, translating into good reinforcing properties for composites. The nanocellulose material may include nanofibrillated cellulose, nanocrystalline cellulose, or both. In some embodiments, the nanocellulose material is hydrophobic via deposition of some lignin onto the cellulose surface. Optionally, sugars derived from amorphous cellulose and hemicellulose may be separately fermented, such as to monomers for various polymers. These polymers may be combined with the nanocellulose to form completely renewable composites. | 2014-06-05 |
20140155302 | OIL WELL DRILLING FLUIDS, OIL WELL CEMENT COMPOSITION AND SLURRY OF WEIGHTING MATERIAL - The present invention relates to oil well drilling comprising a weighting agent consisting of microfine, particulate ilmenite having a FeTiO | 2014-06-05 |
20140155303 | ZERO-LEAKOFF GEL - A silicate gel composition that is useful for sealing the face of a fracture of a formation. A method of sealing a face of a fracture of a formation with the silicate gel composition and diverting an acid treatment fluid. | 2014-06-05 |
20140155304 | ANTICORROSIVE COMPOSITION - The present invention relates to the discovery that melanoidins, and higher molecular weight fractions of products containing melanoidins, provide significant corrosive inhibition, which render these melanoidins suitable for use as anticorrosive agents in corrosive environments. In addition to being highly anticorrosive, the melanoidins of the present invention are environmentally friendly and non-toxic, and can be found in animal food and in human foodstuffs. | 2014-06-05 |
20140155305 | THICKENING OF FLUIDS - An aqueous solution comprising a thickening polymer with diol groups distributed along it, such as guar or other polysaccharide, is cross linked with a cross-linker which contains a plurality of boroxole groups of the partial formula | 2014-06-05 |
20140155306 | Lubricating Grease Based On Perfluoropolyether - A lubricating grease is provided that comprises 90 to 99.45 percent by mass of perfluoropolyethers (PFPE) and 0.5 to 5 percent by mass of fumed silica. | 2014-06-05 |
20140155307 | BIODEGRADABLE LUBRICATING OIL COMPOSITION - [PROBLEMS] To provide a biodegradable lubricating oil composition which has excellent biodegradability, a high viscosity index, a low pour point, a high flash point, being satisfactory with lubricity, oxidative stability, property of preventing the corrosion of iron and non-ferrous metals, and suitability for use with sealing materials. | 2014-06-05 |
20140155308 | COPOLYMERS OF POLYAMINOPOLYOLEFINS AND POLYANHYDRIDES AND METHODS OF THEIR PREPARATION - Provided herein are copolymers of a polyaminopolymer and polyanhydride, wherein the polyaminopolymer comprises a polyaminopolyolefin; and methods of their preparation. | 2014-06-05 |
20140155309 | COMPOSITION COMPRISING FATTY ACYL ISETHIONATE AND SYNTHETIC WAX AND METHOD PRODUCING THE SAME - A method of preparing a component of a personal care bar, the method comprising: (a) providing a composition comprising an isethionate surfactant at a temperature of at least 20° C.; (b) combining the composition comprising the isethionate surfactant with a synthetic 5 wax and optional further components at a temperature of at least 120° C.; and (c) cooling the mixture obtained in step (b). | 2014-06-05 |
20140155310 | DYNAMIC MULTI-PURPOSE COMPOSITION FOR THE REMOVAL OF PHOTORESISTS AND METHOD FOR ITS USE - The disclosure is directed solutions and processes to remove substances from substrates. The substances can include photoresist. The solutions can include dimethylsulfoxide, a quaternary ammonium hydroxide, an alkanolamine, and less than 3% by weight water of a total weight of the solution. The quaternary ammonium hydroxide can include tetramethylammonium hydroxide, dimethyldipropylammonium hydroxide, or methyltriethylammonium hydroxide. Additionally, the solutions can include a secondary solvent. For example, the secondary solvent can include an alcohol. In another example, the secondary solvent can include ethylene glycol. Methods for the preparation and use of the solution to remove substances from substrates are also described. | 2014-06-05 |
20140155311 | CLEANING COMPOSITION - An industrial cleaning composition is provided that includes: (a) from 5 to 50% by volume of an anionic surfactant having a log | 2014-06-05 |
20140155312 | APE-FREE LAUNDRY EMULSIFIER - A detergent emulsifier for laundry and other hard surface cleaning using an APE-free surfactant blend is disclosed. The emulsifier system is efficacious for removal of oily soils and greasy food removal. The compositions according to the invention include linear and branched fatty alcohol ethoxylates and ethoxylate propoxylate block copolymers. Methods of using the same are disclosed. | 2014-06-05 |
20140155313 | HYDROGELS WITH COVALENTLY LINKED POLYPEPTIDES - The present invention provides methods of synthesizing hydrogels that contain covalently linked polypeptides. These polypeptides may be tetravalent peptides or polypeptides that bind to cell surface receptors. The hydrogels synthesized by the methods of the present invention may be used in wound dressings or applied directly to wounds to promote healing. | 2014-06-05 |
20140155314 | PEPTIDE COMPOSITIONS AND METHODS FOR TREATING LUNG INJURY, ASTHMA, ANAPHYLAXIS, ANGIOEDEMA, SYSTEMIC VASCULAR PERMEABILITY SYNDROMES, AND NASAL CONGESTION - Provided herein are peptide inhibitors of the interaction between End Binding Protein 3 (EB3) and Inositol 1,4,5-Trisphosphate Receptor Type 3 (IP3R3). Also provided are methods and materials for treating lung injury, including acute lung injury, which may include hyperpermeability of lung vessels, vascular leakage, the development of edema, asthma, anaphylaxis, angioedema, systemic vascular permeability syndromes, and nasal congestion. | 2014-06-05 |
20140155315 | SYNTHETIC LINEAR APELIN MIMETICS FOR THE TREATMENT OF HEART FAILURE - The invention provides a synthetic polypeptide of Formula I′ (SEQ ID NO: 1): | 2014-06-05 |
20140155316 | FIBROBLAST GROWTH FACTOR 1 PROTEIN FRAGMENTS AND METHODS OF USE - The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine fibroblast growth factor (“FGF”) and the C-terminus includes a C-terminal portion of an FGF19 molecule. The portion of the paracrine FGF is modified to decrease binding affinity for heparin and/or heparan sulfate compared to the portion without the modification. The present invention also relates to pharmaceutical compositions including chimeric proteins according to the present invention, methods for treating a subject suffering from diabetes, obesity, or metabolic syndrome, and methods of screening for compounds with enhanced binding affinity for the βKlotho-FGF receptor complex involving the use of chimeric proteins of the present invention. | 2014-06-05 |
20140155317 | SELECTIVELY TARGETED ANTIMICROBIAL PEPTIDES AND THE USE THEREOF - The present invention relates to targeting peptides capable of specifically binding to microbial organisms (e.g., | 2014-06-05 |
20140155318 | PEPTIDES AND COMPOSITIONS FOR PREVENTION OF CELL ADHESION AND METHODS OF USING SAME - Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of FDYDWY (SEQ ID NO: 2), SFSQNKSVHSFDYDWYNVSDQADLKN (SEQ ID NO: 3) or CSFSQNKSVHSFDYDWYNVSDQADLKNC (SEQ ID NO: 1), or any cyclized version thereof, and methods of using same, including for treatment of or prevention of formation of microbial biofilms and against adhesion of a cell to a surface. | 2014-06-05 |
20140155319 | ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE THEREOF - The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif. | 2014-06-05 |
20140155320 | USE OF STORAGE STABLE VISCOUS PHOSPHOLIPID DEPOT TO TREAT WOUNDS - The present invention provides a method of preventing and/or treating a wound infection by introducing to a wound a clear depot comprising a hydrophilic water-soluble pharmaceutically active agent(s) selected from the group consisting of vancomycin, gentamicin, and a mixture thereof, water, a phospholipid, an oil, a pH adjusting agent, and a viscosity modifying agent, wherein the water present in the viscous depot is no more than about 4 wt %, no more than about 2 wt %, or no more than about 0.5 wt % of water relative to the total weight of the depot. | 2014-06-05 |
20140155321 | Polypeptides and Their Use - The present invention relates to a polypeptide or a product comprising said polypeptide for use in the treatment and/or prevention of a fungal infection caused by | 2014-06-05 |
20140155322 | Method of Preventing Or Reducing Scarring Of Human Skin - Insulin or a peroxisome proliferator-activated receptor (PPAR) agonist provides reliable and effective prevention of scarring in human skin, or at least a reduction in the severity of scarring. The application of insulin or the PPAR agonist to wounds topically or by local injection is particularly advantageous since it simultaneously reduces/prevents scarring whilst enhancing re-epithelialisation of the wound and thus provides a dual action wound healing treatment. The present invention accordingly provides a highly effective prophylactic treatment for any individual suffering tissue trauma to reduce and/or prevent normal and/or pathological scarring. | 2014-06-05 |
20140155323 | POLYPEPTIDES, NUCLEIC ACID MOLECULE ENCODING POLYPEPTIDES, AND USES OF POLYPEPTIDES - A polypeptide, a nucleic acid molecule encoding the polypeptide and a pharmaceutical composition comprising the polypeptide are provided. The polypeptide is as defined in the description, can bind to insulin receptors, and is effective in reducing blood sugar, reducing glycated hemoglobin, and ameliorating hepato-renal disorders caused by diabetes. | 2014-06-05 |
20140155324 | NOVEL PEPTIDES AND USES THEREOF IN THERAPEUTIC METHODS - The invention relates to polypeptides exhibiting metabolic-modulating as well as immunomodulatory properties, nucleic acids encoding them, compositions comprising them, and methods of treating metabolic disorders and/or immune-related disorders comprising their administration and to their use in preparing pharmaceutical compositions for the treatment, amelioration, prophylaxis or delaying the onset of at least one of a metabolic disorder and an immune-related disorder. | 2014-06-05 |
20140155325 | EGFR AND C-MET FIBRONECTIN TYPE III DOMAIN BINDING MOLECULES - Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders. | 2014-06-05 |
20140155326 | EGFR AND C-MET FIBRONECTIN TYPE III DOMAIN BINDING MOLECULES - Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders. | 2014-06-05 |
20140155327 | Process for the Synchronization of Ovulation for Timed Breeding Without Heat Detection - A method for synchronizing ovulation in sows and gilts without heat detection by a single injection of hormones is disclosed. A hormone, gonadotropin releasing hormone (GnRH), luteinizing hormone (LH), follicle stimulating hormone (FSH), human chorionic gonadotropin (hCG), analogues, derivatives, agonists or combinations thereof is administered to an open sow post weaning at a specific time to stimulate ovulation of mature responsive follicles. The sow is then bred without heat detection at a specific subsequent timed interval after injection with hormone, with one or two artificial or natural breedings. In gilts, the hormone is injected at a timed interval from onset of estrus or at a specific timed interval following Prostaglandin F2a for those gilts which have been held in a state of pseudopregnancy. | 2014-06-05 |
20140155328 | ALPHA-AND GAMMA-MSH ANALOGUES - The present invention provides peptide analogues of α-MSH and γ-MSH, comprising the amino acid sequence of human α-MSH or γ-MSH, or variants thereof, and having a branched amino acid probe in the N-terminal part of the peptide. | 2014-06-05 |
20140155329 | Long-Acting Peptide Analogs - Long-acting agonistic analogs for CLR/RAMP receptors are provided that have an extended half-live in vivo. | 2014-06-05 |
20140155330 | Compositions And Methods For Modulating Apoptosis - Peptides, compositions and methods for modulating apoptosis, useful for treating diseases or disorders characterized by dysregulated apoptosis, such as cancer or neurodegenerative diseases. Screening methods for identifying agents that mediate apoptosis by regulating Atg12 binding to Bcl-2 family members. | 2014-06-05 |
20140155331 | NOVEL HIGH AFFINITY BIVALENT HELICALLY CONSTRAINED PEPTIDE AGAINST CANCER - The present invention describes a novel bivalent helically constrained peptide targeted against S100B that is an effective anti-cancer drug against cancers that over-express S100B. This helix mimetic targeted against S100B induces rapid apoptosis in cancer cells that over-express a calcium binding protein S100B through simultaneous inhibition of key growth pathways including activation of p53. | 2014-06-05 |
20140155332 | SELECTIVE INHIBITORS OF TUMOR-INITIATING CELLS - Described herein are novel malignancy associated gene signature biomarkers, and assays and methods thereof, to classify prognosis or malignant potential of a cancer and identify cancer-initiating cells. The malignancy associated gene signature biomarkers, assays and methods described herein provide, in part, new methodologies to screen for novel drugs for treating cancers and tumors, such as, for example, triple-negative breast tumors. Using the assays and methods described herein proteasome inhibitors, histone deacetylase inhibitors, and glycolysis inhibitors, were identified as being highly effective in altering gene expression signatures specifically in malignant or cancer-initiating cells. | 2014-06-05 |
20140155333 | COMPOSITIONS AND METHODS FOR CANCER TREATMENT USING TARGETED CARBON NANOTUBES - Compositions for detecting and/or destroying cancer tumors and/or cancer cells via photodynamic therapy are disclosed, as well as methods of use thereof. The compositions comprise a linking protein or peptide attached to or otherwise physically associated with a carbon nanotube to form a targeted protein-carbon nanotube complex. | 2014-06-05 |
20140155334 | POLYPHOSPHATE AND PYROPHOSPHATE DERIVATIVE OF SACCHARIDES - The present invention provides, among other things, phosphorylated and pyrophosphate derivatives of mono-, di- and oligosaccharides, as well as structural derivatives of these compounds. These compounds have a variety of uses including for pharmaceutical applications. Also provided are methods of use in the treatment of disease, including diseases related to oxygen delivery. | 2014-06-05 |
20140155335 | ELASTIN PROTECTIVE POLYPHENOLICS AND METHODS OF USING THE SAME - Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging. The present invention provides methods and compositions containing the polyphenols ellagic acid and/or tannic acid for protection against degradation of cutaneous elastic fibers by the elastolytic enzymes. The use of ellagic acid and/or tannic acid increased the overall deposition of elastic fibers in healthy and damaged skin cells. The protection of both intra-tropoelastin and extra-cellular mature elastic fibers from proteolytic enzymes by ellagic acid and tannic acid caused an increase in the net deposition of elastic fibers. Therefore, embodiments of the present invention provide methods and composition for the treatment of skin and prevention and treatment of degradation of dermal elastic fibers. | 2014-06-05 |
20140155336 | WATER-SOLUBLE CAMPTOTHECIN DERIVATIVE, PHARMACEUTICAL COMPOSITION AND USE THEREOF - The present invention relates to a water soluble derivative of camptothecin and preparation method thereof, the derivative having a structure of formula I and being appropriate in water solubility, and having anti-cancer activity and stability of lactonic ring. The present invention also relates to a method for synthesizing the compound and medical use of the compound. | 2014-06-05 |
20140155337 | Molluscicidal Agents and Uses Thereof - The present invention provides molluscicidal saponins and saponin fractions from | 2014-06-05 |
20140155338 | USE OF PDE III INHIBITORS FOR THE REDUCTION OF HEART SIZE IN MAMMALS SUFFERING FROM HEART FAILURE - A phosphodiesterase type III (PDE III) inhibitor or Ca | 2014-06-05 |
20140155339 | HYDROXYTYROSOL AND OLEUROPEIN COMPOSITIONS FOR INDUCTION OF DNA DAMAGE, CELL DEATH AND LSD1 INHIBITION - Compositions comprising hydroxytyrosol-containing formulations and treatment regiments comprising hydroxytyrosol and/or oleuropein and chemotherapeutic agents are disclosed. Compositions and/or regiments may optionally include the administration of vitamins, minerals, and anti-oxidants. Methods for using these compositions and treatment regimens for treating subjects for diseases, such as a malignancy, and for inducing or enhancing angiogenesis, treating or preventing oxidative stress, for treating or preventing high glucose-induced dysfunction, treating or preventing chemotherapy-induced dysfunction, and for improving cell viability are provided. Various methods for use of the hydroxytyrosol compositions for inhibition of lysine specific demethylase 1 (LSD1) in various cancers are also provided. | 2014-06-05 |
20140155340 | GEL BASED LIVESTOCK FEED, METHOD OF MANUFACTURE AND USE - A method of making a gel-type livestock feed includes initially forming a feed mixture by mixing feed nutrient components, water, alginate, and a calcium component insoluble in water or a sequestrate to inhibit the calcium component from reacting with the alginate. Once the feed mixture is formed, the calcium component is solubilized or the sequestrates affecting the reactivity between the alginate and the calcium component is removed such that a gel feed is formed that includes a gel matrix containing the feed nutrient components. The gel feed may then be fed to the livestock. In another aspect of the present invention, piglets are weaned by feeding the gel feed for at least seven days directly after weaning. The gel feed may also include protein derived from blood with or without egg protein. | 2014-06-05 |
20140155341 | USE OF SS'-DIMETHYL-GLIOTOXIN AS DIAGNOSTIC MARKER OF PATHOLOGIES CAUSED BY GLIOTOXIN-PRODUCING FUNGI OR THEIR DERIVATIVES - The present invention relates to an in vitro method of diagnosis, prognosis and/or monitoring of pathologies caused by gliotoxin-producing fungi or their derivatives, characterized in that it is based on the detection of SS′-dimethyl-gliotoxin in a biological sample. Also relates to the use of the SS′-dimethyl-gliotoxin as marker for the diagnosis, prognosis and/or monitoring of pathologies caused by gliotoxin-producing fungi or their derivatives in a subject. | 2014-06-05 |
20140155342 | PATCH CONTAINING DICLOFENAC AND THIOCOLCHICOSIDE - The present invention relates to a patch for the transdermal release of diclofenac or a pharmaceutically acceptable salt thereof, in particular diethylamine salt, and thiocolchicoside. | 2014-06-05 |
20140155343 | TARGETED DELIVERY OF DRUGS, THERAPEUTIC NUCLEIC ACIDS AND FUNCTIONAL NUCLEIC ACIDS TO MAMMALIAN CELLS VIA INTACT KILLED BACTERIAL CELLS - A composition comprising intact killed bacterial cells that contain a therapeutic nucleic acid, a drug or a functional nucleic acid is useful for targeted delivery to mammalian cells. The targeted delivery optionally employs bispecific ligands, comprising a first arm that carries specificity for a killed bacterial cell surface structure and a second arm that carries specificity for a mammalian cell surface receptor, to target killed bacterial cells to specific mammalian cells and to cause endocytosis of the killed bacterial cells by the mammalian cells. Alternatively, the delivery method exploits the natural ability of phagocytic mammalian cells to engulf killed bacterial cells without the use of bispecific ligands. | 2014-06-05 |
20140155344 | COMBINATION THERAPY METHODS FOR TREATING PROLIFERATIVE DISEASES - The present invention provides combination therapy methods of treating a proliferative disease (such as cancer) comprising a first therapy comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a second therapy which may include the administration of an effective amount of at least one other agent that modifies the epigenetics in a cell. | 2014-06-05 |
20140155345 | BIOTINYLATED COMPOUNDS - The invention provides new biotinylated compounds and methods for their use. | 2014-06-05 |
20140155346 | COSMETIC AND/OR DERMATOLOGICAL USE OF OLIGOSACCHARIDE COMPOUNDS FOR PREVENTING AND TREATING STRETCH MARKS - The present invention relates to a topical composition, in particular a cosmetic and/or dermatological composition, to be used for preventing and/or treating stretch marks, including, in a physiologically acceptable medium, an effective amount of at least one synthetic polysulfated oligosaccharide having 1 to 4 glycose units, the salts thereof, and/or the derivatives thereof. The invention also relates to a cosmetic method, in particular for treating stretch marks, including at least one step of applying said composition to the skin. | 2014-06-05 |
20140155347 | Spray Drying of High Molecular Weight Hyaluronic Acid - A method of producing spray-dried hyaluronic acid comprising a) spray drying hyaluronic acid, wherein the concentration of the hyaluronic acid in the feed to the spray dryer is in the range of from 3.5 g/l to 7.0 g/l; b) having the temperature in the feed to the spray dryer in the range of from 0° C. to 100° C.; and wherein the molecular weight of the hyaluronic acid in the feed to the spray dryer is ≧1200 kDa. | 2014-06-05 |
20140155348 | Inclusion Compounds of Fumagillol Derivative or its Salt, and Pharmaceutical Compositions Comprising the Same - The present invention relates to an inclusion compound of fumagillol derivative or its salt with hydroxypropyl-β-cyclodextrin or sulfobutylether-7-β-cyclodextrin, and pharmaceutical compositions comprising the same. The inclusion compound according to the present invention has superior water solubility and stability while exhibiting low toxicity, rendering it valuable as an anticancer agent or inhibitor of tumor metastasis. | 2014-06-05 |
20140155349 | Health Care - The use of a pharmaceutical regimen to deter in an individual, as the individual ages, the development of a cardiovascular disease (CVD) or Alzheimer's disease or to treat an individual who has CVD or Alzheimer's, the individual ingesting on a daily basis a regimen comprising pharmaceutically effective amounts of magnesium salicylate and naproxen, the amount of the magnesium salicylate being no greater than about 260 mg, and also the use of a pharmaceutical regimen to treat an individual who has Type 2 diabetes, the regimen being ingested daily by the individual and comprising pharmaceutically effective amounts of at least one glucose-lowering drug and magnesium salicylate in an amount no greater than about 260 mg. | 2014-06-05 |
20140155350 | Prodrugs of Neuraminidase Inhibitors - A new class of neuramidase inhibitor prodrugs is provided characterized by a prodrug moiety of a carboxyl group modified to form a carbonyl ethoxy amino acid, a carbonyl ethoxy dipeptide or a carbonyl ethoxy tripeptide, a guanidine group modified to form a carbonyl ethoxy amino acid, a carbonyl ethoxy dipeptide, a carbonyl ethoxy tripeptide; a primary alcohol modified to form an esterified single amino acid, dipeptide or tripeptide of zanavimir of the unaltered therapeutic agent. Exemplary therapeutic agents so modified to form prodrugs include zanavimir, oseltamivir and peramivir. The prodrug has increased oral bioavailability relative to the unaltered neuraminidase inhibitor and is effective in the inhibition of viral infections involving neuraminidase in the viral reproductive cycle. | 2014-06-05 |
20140155351 | PROCESS FOR THE PREPARATION OF PRASUGREL AND SEVERAL NOVEL CRYSTALLINE FORMS OF PRASUGREL HYDROCHLORIDE - Disclosed herein are a process or method for the preparation of prasugrel and several novel crystalline forms of prasugrel hydrochloride. The process comprises preparation of prasugrel by acetylation in solvents which have low boiling point and/or low toxicity, and the process not only avoids using solvents which have high boiling point and/or high toxicity such as toluene, acetonitrile and so on, but also resolves the problem about thermal instability of prasugrel, and the loss of prasugrel is reduced, as well as the yield is raised. The yield of prasugrel is higher than 85% and the purity is higher than 99.5%. The process can prepare prasugrel and its pharmaceutically acceptable salts. The novel crystalline forms of prasugrel hydrochloride are crystalline form H1, H2 and H3, and their performance in oral absorbability, activating metabolism and inhibiting platelet aggregation is excellent. They have a low toxicity and good thermal stability, and are applicable to the preparation of a drug for preventing or treating diseases caused by thrombosis or embolism. | 2014-06-05 |
20140155352 | COSMETIC TREATMENT PROCESSES AND KIT - The present invention relates to a cosmetic process for treating keratin materials, which can give them, especially in a long-lasting and reversible manner, interesting cosmetic properties; this process comprising the application to said materials:
| 2014-06-05 |
20140155353 | COSMETIC COMPOSITION - Provided is a cosmetic composition which has a structure-recovering property, is transparent, is satisfactory in smoothness when applied to the skin or hair, and has a good feeling in use, which comprises components (A) to (D) as described. | 2014-06-05 |
20140155354 | PROCESSES FOR THE PREPARATION OF PHOSPHOLIPID-ENRICHED DAIRY PRODUCTS AS NEUTRACEUTICALS FOR THE FORMULATION OF FUNCTIONAL FOODS, AND NEUTRACEUTICAL AND/OR PHARMACEUTICAL COMPOSITIONS THEREOF - The present invention discloses processes for the preparation of phospholipid-enriched dairy products as nutraceuticals for the formulation of functional foods, and nutraceutical and/or pharmaceutical compositions thereof, the processes include the steps of: combining a non-dairy-based PL-containing material with an oil component and water to form a paste; removing an excess amount of the water from the paste to form a PL-oil solution; and mixing the PL-oil solution with a dairy component, thereby obtaining a PL-enriched dairy product. Preferably, the PL-containing material includes at least one material selected from the group consisting of: a vegetal-derived lecithin, a non-vegetal-derived lecithin, a de-oiled lecithin, a native lecithin-oil solution, and an enzymatically-processed lecithin. Preferably, the PL-oil solution has a weight-to-weight (w-w) concentration of at least about 0.01% of a residual amount of the water to the PL-containing material. | 2014-06-05 |
20140155355 | MAO-B INHIBITORS USEFUL FOR TREATING OBESITY - The invention provides novel compounds of formulae I and II: | 2014-06-05 |
20140155356 | CURABLE BONE SUBSTITUTE - A novel composition, kit, and method of using the composition as a bone substitute for dental, orthopedic and drug delivery purposes. Specifically, the bone substitute comprises a plurality of polymeric beads having a crosslinkable shell where the shell is cured by light and/or chemical curing. | 2014-06-05 |
20140155357 | SUBSTITUTED TETRACYCLINE COMPOUNDS - The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression. | 2014-06-05 |