23rd week of 2017 patent applcation highlights part 29 |
Patent application number | Title | Published |
20170159065 | MEANS AND METHODS TO INCREASE PLANT YIELD - This disclosure relates to plants having a decreased expression of the KIX8 and KIX9 genes that result in an increased yield, particularly an increased leaf biomass. The disclosure provides plants and chimeric genes that can be used to decrease the combined KIX8/KIX9 gene expression. | 2017-06-08 |
20170159066 | METHOD FOR MANUFACTURING TRANSGENIC PLANT PRODUCING IMMUNOGENIC COMPLEX PROTEINS AND IMMUNOGENIC COMPLEX PROTEINS OBTAINED THEREFROM - The present invention relates to a method for manufacturing a transgenic plant producing immunogenic complex proteins and immunogenic complex proteins obtained therefrom and, more specifically, to a method for manufacturing a transgenic plant producing immunogenic complex proteins, a plant manufactured by the method, and immunogenic complex proteins obtained from the plant, wherein the method comprises the steps of: (a) manufacturing a transgenic plant expressing an antigen; (b) manufacturing a transgenic plant expressing an antibody specific to the antigen in step (a); and (c) cross-breeding the plants in steps (a) and (b) to manufacture a cross-bred plant. Immunogenic complex proteins can be mass-produced through the method for manufacturing a transgenic plant, comprising steps (a) to (c), and the transgenic plant manufactured by the method, of the present invention. Further, the immunogenic complex proteins (antigen-antibody complex) obtained from the plant have a gigantic four-dimensional structure, thereby having an excellent immune reaction boosting effect, thus exhibiting an excellent antibody producing capacity in a host animal, even without the use of an immune adjuvant. | 2017-06-08 |
20170159067 | QTLs ASSOCIATED WITH AND METHODS FOR IDENTIFYING SHATTER RESISTANCE IN CANOLA - Markers associated with shatter resistance in | 2017-06-08 |
20170159068 | PLANTS HAVING ALTERED AGRONOMIC CHARACTERISTICS UNDER ABIOTIC STRESS CONDITIONS AND RELATED CONSTRUCTS AND METHODS INVOLVING ABIOTIC STRESS TOLERANCE GENES - Isolated polynucleotides and polypeptides, and recombinant DNA constructs useful for conferring improved nitrogen use efficiency and/or drought tolerance and/or cold tolerance; compositions (such as plants or seeds) comprising these recombinant DNA constructs; and methods utilizing these recombinant DNA constructs are disclosed. The recombinant DNA constructs comprise a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotides encode low nitrogen tolerance polypeptides. | 2017-06-08 |
20170159069 | PATHOGEN RESISTANT CITRUS COMPOSITIONS, ORGANISMS, SYSTEMS, AND METHODS - The present disclosure relates, according to some embodiments, to pathogen resistant citrus compositions, organisms, systems, and methods. For example, a composition may comprise a peptide (e.g., a defensin peptide) and/or a nucleic acid (e.g., a defensin nucleic acid). A pathogen resistant citrus plant may comprise, in some embodiments, a defensin peptide and/or an expressible nucleic acid encoding a defensin peptide. | 2017-06-08 |
20170159070 | TRANSPOSON FOR GENOME MANIPULATION - Disclosed is a vector comprising a piggyBac like element (PLE) transposon and/or transposase. Also disclosed are vectors comprising a combination of the vectors of the present disclosure, a transformation system comprising the vectors of the present disclosure, an oligonucleotide primer, methods of amplifying nucleotide sequences, methods of transforming a cell with a gene and a transgenic organism. | 2017-06-08 |
20170159071 | RAAV-BASED COMPOSITIONS AND METHODS FOR TREATING ALPHA-1 ANTI-TRYPSIN DEFICIENCIES - The invention relates to isolated nucleic acids and rAAV-based compositions, methods and kits useful for treating genetic diseases (e.g., alpha-1 antitrypsin deficiency). | 2017-06-08 |
20170159072 | Endothelial-targeted Adenoviral Vectors, Methods and Uses Therefor - Disclosed are adenovirus vectors comprising a ROBO4 enhancer/promoter operatively linked to a transgene. Also disclosed are adenovirus vectors comprising a chimeric AD5-T4 phage fibritin shaft, a trimerization domain displaying a myeloid cell-binding peptide (MBP), and a ROBO4 enhancer promoter operatively linked to a transgene. Also disclosed are methods of expressing a transgene in an endothelial cell in vivo, comprising administering to a mammal an adenovirus comprising a ROBO4 enhancer/promoter operatively linked to a transgene. Also disclosed are uses of the adenoviral vectors, including mobilization of granulocytes, monocytes and lymphocytes from bone marrow, mobilization of cancer cells in vivo, selective targeting of endothelial cells, and cancer treatment methods. | 2017-06-08 |
20170159073 | ENGINEERED NUCLEIC ACID-TARGETING NUCLEIC ACIDS - The present disclosure provides engineered polynucleotide sequences that form scaffolds and nucleoprotein complexes comprising such engineered polynucleotide sequences that form scaffolds and nucleic acid binding proteins. Nucleic acid sequences encoding the engineered polynucleotide sequences that form scaffolds, as well as expression cassettes, vectors and cells comprising such polynucleotide sequences, are described. A variety of methods for making and using the engineered polynucleotide sequences that form scaffolds are also disclosed. | 2017-06-08 |
20170159074 | RECOMBINANT MICROORGANISMS FOR THE ENHANCED PRODUCTION OF MEVALONATE, ISOPRENE, ISOPRENOID PRECURSORS, ISOPRENOIDS, AND ACETYL-COA-DERIVED PRODUCTS - The invention features compositions and methods for the increased production of mevalonate, isoprene, isoprenoid precursor molecules, isoprenoids, and/or acetyl-CoA-derived products in recombinant microorganisms by engineering the microorganisms to comprise one or more acetylating proteins such that the expression and/or activity of the one or more acetylating proteins is modulated. | 2017-06-08 |
20170159075 | MICROORGANISMS AND METHODS FOR IMPROVING PRODUCT YIELDS ON METHANOL USING ACETYL-COA SYNTHESIS - The invention provides non-naturally occurring microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing carbon flux through acetyl-CoA. In some embodiments, the microbial organisms having such pathways also include pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation. The enhanced carbon flux through acetyl-CoA, in combination with pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation can, in some embodiments, be used for production of a bioderived compound. Accordingly, in some embodiments, the microbial organisms of the invention can include a pathway capable of producing a bioderived compound of the invention. The invention still further provides a bioderived compound produced by a microbial organism of the invention, culture medium having the bioderived compound of the invention, compositions having the bioderived compound of the invention, a biobased product comprising the bioderived compound of the invention, and a process for producing a bioderived compound of the invention. | 2017-06-08 |
20170159076 | METHOD FOR FRACTIONATING A LIGNOCELLULOSIC BIOMASS - The present invention relates to a method for fractionating a lignocellulosic biomass. More specifically, the present invention lies in the field of cellulose solvent- and organic solvent-based lignocellulose fractionation (COSLIF) of lignocellulosic biomasses. In this type of process, a cellulose solvent, such as phosphoric acid or an ionic liquid is used to disrupt the structure of cellulose in a lignocellulosic biomass. Subsequent washing and treatment steps are used to fractionate the biomass. | 2017-06-08 |
20170159077 | PROCESSING BIOMASS - Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example, systems are described that can be useful in enhancing sugar yields from biomass. | 2017-06-08 |
20170159078 | PROCESS FOR PRODUCING FUEL USING TWO FERMENTATIONS - A process is provided for forming a fuel or a fuel intermediate from two fermentations that includes feeding an aqueous solution comprising a fermentation product from a first bioreactor to a second bioreactor and/or a stage upstream of the second bioreactor, which also produces the fermentation product. The aqueous solution may be added at any stage of the second fermentation and/or processing steps upstream from the second bioreactor that would otherwise require the addition of water. Accordingly, the product yield is increased while fresh/treated water usage is decreased. | 2017-06-08 |
20170159079 | PROCESS FOR THE MANUFACTURE OF BUTANOL OR ACETONE - A process for the manufacture of butanol, acetone and other renewable chemicals utilizes one or more of by-products of the manufacture of malt whisky, such as pot ale and spent lees, biomass substrates, such as paper, sludge from paper manufacture and spent grains from distillers and brewers, and diluents, such as water and spent liquid from other fermentations. The process includes treating a substrate to hydrolyze it and fermenting the treated. Also provided is a biofuel including butanol manufactured according to the process. | 2017-06-08 |
20170159080 | CHEMICAL ENGINEERING PROCESSES AND APPARATUS FOR THE SYNTHESIS OF COMPOUNDS - The present invention provides methods for producing cannabinoids and cannabinoid analogs as well as a system for producing these compounds. The inventive method is directed to contacting a compound according to Formula I or Formula II with a cannabinoid synthase. | 2017-06-08 |
20170159081 | METHOD FOR PRODUCING ACETOIN - The present invention relates to a recombinant yeast having a reduced pyruvate decarboxylase activity, in the genome of which has been inserted:—one or more nucleic acids encoding an acetolactate synthase or ALS,—one or more nucleic acids en coding an acetolactate decarboxylase or ALD, and—one or more copies of a nucleic acids encoding a NADH oxidase or NOXE. | 2017-06-08 |
20170159082 | METHODS AND MATERIALS FOR PRODUCING 7-CARBON MONOMERS - This document describes biochemical pathways for producing 7-aminoheptanoic acid using a β-ketoacyl synthase or a β-ketothiolase to form either a 5-amino-3-oxopentanoyl-[ACP] or 5-amino-3-oxopentanoyl-CoA intermediate. 7-aminoheptanoic acid can be enzymatically converted to pimelic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol or the corresponding salts thereof. This document also describes recombinant microorganisms producing 7-aminoheptanoic acid as well as pimelic acid, 7-hydroxyheptanoic acid, heptamethylenediamine and 1,7-heptanediol or the corresponding salts thereof. | 2017-06-08 |
20170159083 | ARGININE SUPPLEMENTATION TO IMPROVE EFFICIENCY IN GAS FERMENTING ACETOGENS - The invention provides methods for improving efficiency of fermentation by arginine supplementation, and genetically modified bacterium for use therefor. More particularly the invention provides methods for (i) increasing the production ATP intensive products with arginine supplementation, (ii) increasing utilization of arginine by a C1-fixing bacterium; and (iii) providing C1-fixing bacterium with optimized arginine de-aminase pathways. | 2017-06-08 |
20170159084 | Modified Cyanobacteria - Provided is a cyanobacterium with improved productivity of fatty acid. A method for producing a modified cyanobacterium, comprising causing loss of functions of an AbrB-like transcriptional regulator and acyl-ACP synthetase in a cyanobacterium. | 2017-06-08 |
20170159085 | MICROORGANISMS FOR PRODUCING DIAMINE AND PROCESS FOR PRODUCING DIAMINE USING THEM - The present invention relates to a microorganism for producing diamine, in which activity of a protein having an amino acid sequence of SEQ ID NO: 6 or an amine acid sequence having 42% or higher sequence homology with SEQ ID NO: 6 is introduced or enhanced, and a method of producing diamine using the same. | 2017-06-08 |
20170159086 | METHODS AND MATERIALS FOR PRODUCING 5 AND 7-CARBON MONOMERS - This document describes biochemical pathways for biosynthesizing a 3-oxo-7-hydroxyheptanoyl-CoA intermediate using a β-ketothiolase, and enzymatically converting 3-oxo-7-hydroxyheptanoyl-CoA to 7-hydroxyheptanoic acid. -7-hydroxyheptanoic acid can be further enzymatically converted to pimelic acid, 7-aminoheptanoic acid, heptamethylenediamine or 1,7-heptanediol. This document also describes recombinant hosts producing 7-hydroxyheptanoic acid as well as pimelic acid, 7-aminoheptanoic acid, heptamethylenediamine and 1,7-heptanediol. | 2017-06-08 |
20170159087 | Methods of Using Natural and Engineered Organisms to Produce Small Molecules for Industrial Application - Aspects of the invention relate to methods of producing small molecules for industrial application using natural organisms and engineered organisms. | 2017-06-08 |
20170159088 | PROCESSES FOR THE PREPARATION OF (R)-2-(7-(4-CYCLOPENTYL-3-(TRIFLUOROMETHYL)BENZYLOXY)-1,2,3,4-TETRAHYDROC- YCLOPENTA[B]INDOL-3-YL)ACETIC ACID AND SALTS THEREOF - The present invention relates to processes and intermediates useful in the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid of Formula (Ia) and salts thereof, an S1P1 receptor modulator that is useful in the treatment of S1P1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (e.g., acute and chronic inflammatory conditions), cancer, and conditions characterized by an underlying defect in vascular integrity or that are associated with angiogenesis such as may be pathologic (e.g., as may occur in inflammation, tumor development and atherosclerosis). | 2017-06-08 |
20170159089 | METHOD OF PRODUCING GLUCOSE FROM A CELLULOSIC BIOMASS USING ENZYMATIC HYDROLYSIS - The present invention relates to a method of producing glucose from a cellulosic biomass using enzymatic hydrolysis. The present invention also relates to a device for performing such method. | 2017-06-08 |
20170159090 | Compositions for Producing Glucose Syrups - The present invention relates to a method of making glucose syrup from liquefied starch comprising, (a) contacting the liquefied starch with a glucoamylase, a pullulanase, and optionally an alpha-amylase wherein the ratio of pullulanase dose expressed as NPUN/gDS, to alpha-amylase dose expressed as FAU(A)/gDS is at least 60, particularly at least 75, particularly at least 100, more particularly at least 150, more particularly at least 200, more particularly at least 250, more particularly at least 300, more particularly at least 400, more particularly at least 500, more particularly at least 600, more particularly at least 800 or if no alpha-amylase is present the pullulanse is present in a dose of at least 0.5, particularly at least 0.75, particularly at least 1.0, particularly at least 1.5 NPUN/gDS, and (b) saccharifying the liquefied starch. | 2017-06-08 |
20170159091 | BIOMASS FRACTIONATION PROCESS FOR BIOPRODUCTS - A fractionation process for producing value-added products from a lignocellulosic biomass, comprises: a) mechanically refining the lignocellulosic biomass under mild refining conditions to form a refined biomass pulp with enhanced susceptibility to separation of hemicellulose, cellulose and lignin, and enhanced digestibility of carbohydrates in hydrolysis b) separating hemicellulose and sulfur-free high-quality lignin from cellulose in the refined biomass, and, optionally c) producing various bioproducts from the above said process. | 2017-06-08 |
20170159092 | METHODS AND MATERIALS FOR PRODUCING 7-CARBON MONOMERS - This document describes biochemical pathways for producing 7-aminoheptanoic acid using a β-ketoacyl synthase or a β-ketothiolase to form an N-acetyl-5-amino-3-oxopentanoyl-CoA intermediate. 7-aminoheptanoic acid can be enzymatically converted to pimelic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol or corresponding salts thereof. This document also describes recombinant microorganisms producing 7-aminoheptanoic acid as well as pimelic acid, 7-hydroxyheptanoic acid, heptamethylenediamine and 1,7-heptanediol or corresponding salts thereof. | 2017-06-08 |
20170159093 | MODIFICATION OF RNA-RELATED ENZYMES FOR ENHANCED PRODUCTION - The present invention provides, among other things, methods and compositions for large-scale production of capped mRNA using SUMO-Guanylyl Transferase fusion protein. | 2017-06-08 |
20170159094 | PRODUCTION OF GLYCOPROTEINS WITH MAMMALIAN-LIKE N-GLYCANS IN FILAMENTOUS FUNGI - The present disclosure relates to compositions and methods useful for the production of recombinant glycoproteins in filamentous fungal cells, such as | 2017-06-08 |
20170159095 | METHOD OF PRODUCTION OF RECOMBINANT GLYCOPROTEINS WITH INCREASED CIRCULATORY HALF-LIFE IN MAMMALIAN CELLS - Provided herein are methods and recombinant expression systems for the production of recombinant glycoproteins that have increased sialic acid content and contain predominantly alpha2-6 sialic acid linkages. Also provided herein are recombinant glycoproteins that have an increased in vivo circulatory half-life. One potential application of the glycoproteins described herein is for the treatment and prophylaxis of poisoning by neurotoxins. | 2017-06-08 |
20170159096 | METHOD FOR FUSION EXPRESSION OF ION CHANNEL PROTEIN AND TRANSPORT PROTEIN AND PROTEIN FRAGMENT USED THEREFOR - The present invention provides a protein fragment for fusion expression of ion channel protein and transport protein. The protein fragment is a Bril protein fragment or a T4L protein fragment. Also provided is a method for preparing a fusion protein by inserting a Brit protein fragment or T4L protein fragment into the N-terminal, C-terminal or intramembrane loop region of the ion channel protein and transport protein so as to improve its, in-vitro stability and crystallizability. | 2017-06-08 |
20170159097 | CELL FREE TRANSLATION SYSTEM FOR COMPOUND SCREENING AND RELATED USES - The invention provides a cell-free system comprising not more than about 5% wheat germ extract for expressing proteins such as viral proteins and proteins required for viral capsid assembly, and proteins that assemble into multiprotein complexes in a manner analogous to viral capsids, are provided. Further provided are methods for expressing proteins such as viral proteins, proteins required for capsid assembly, and proteins that assemble into multiprotein complexes in a manner analogous to viral capsids using a cell-free system comprising not more than about 5% wheat germ extract. Further provided are methods to assay for compounds that modulate viral protein, viral capsid assembly, and assembly of proteins into multiprotein complexes whose disruption can ameliorate bacterial, parasitic, metabolic, oncologic, immunologic, or CNS disease in a cell-free system comprising not more than about 5% wheat germ extract. | 2017-06-08 |
20170159098 | SALMONELLA DETECTION ARTICLES AND METHODS OF USE - An article for detecting | 2017-06-08 |
20170159099 | PREPARING ANTIBODIES FROM CHO CELL CULTURES FOR CONJUGATION - The invention is based in part on the observation that a CHO cell oxidizing enzyme, particularly QSOX1, can survive a seemingly rigorous antibody purification process to reduce subsequent conjugation efficiency of the antibody to a drug. Whether the oxidizing enzyme survives the purification procedure depends on which purification techniques are employed which can vary from one antibody to another. With knowledge that contamination with a CHO cell oxidizing enzyme is a potential problem for subsequent conjugation, a suitable purification scheme can be devised for any antibody that eliminates or at least reduces CHO oxidizing enzyme(s) to an acceptable level. | 2017-06-08 |
20170159100 | WATER-SOLUBLE ACTIVATABLE MOLECULAR PROBES, INTERMEDIATES FOR THE SYNTHESIS THEREOF AND ASSOCIATED DETECTION METHODS - The invention provides probes with formula (I): | 2017-06-08 |
20170159101 | DRUG-RESISTANT P97 ATPASE MUTATIONS - The invention relates to detection of drug insensitivity by detecting mutations in the p97 gene or the p97 gene product following treatment with a p97 inhibitor, and identification of drugs to overcome such drug insensitivity. | 2017-06-08 |
20170159102 | COMPOSITIONS AND METHOD FOR IDENTIFYING ENZYME AND TRANSPORT PROTEIN INHIBITORS - The invention is directed to compositions to screen for small molecule drugs that inhibit proteases, such as viral proteases, e.g., HIV proteases; and methods for making and using these compositions. The invention provides compositions and methods for identifying compositions, e.g., drug molecules, that can inhibit proteases, e.g., HIV proteases. In alternative embodiments, the invention provides cell-based assays to screen for compositions, e.g., small molecules or drugs, that inhibit or modify the activity of enzymes such as calcium-dependent protein convertases involved in HIV envelop protein processing, including cleavage of the HIV gp160 envelope precursor, resulting in gp120 and gp41 envelope products. | 2017-06-08 |
20170159103 | METHODS AND COMPOSITIONS FOR ASSAYING THE ACTIVITY OF ONE OR MORE LYSOSOMAL ENZYMES - Methods and liquid compositions for assaying the activity of one or more lysosomal enzymes in a sample are provided. In some embodiments, the assay is a multiplexed assay for the activities of a plurality of lysosomal enzymes in the sample. The compositions and methods can comprise or employ: one or more metal cations effective for precipitating sulfate ions, one or more metal cations effective for precipitating phosphate ions, a maltase glucoamylase inhibitor, a beta-N-acetylhexosaminidase inhibitor, and one or more surfactants. | 2017-06-08 |
20170159104 | METHODS FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN SOLUTION - Disclosed is a method for measuring the concentration of an analyte or analytes in a solution. Although the methods can be conducted using a number of different assay formats, in one embodiment, the assays are conducted in reaction vessels defined, at least in part, by the distal ends of fiber optic strands. | 2017-06-08 |
20170159105 | Enzyme Assays on a Droplet Actuator - The invention is directed to droplet actuator devices and assay methods. The invention includes assay methods of conducting an assay comprising combining a sample with an umbelliferyl derivative, wherein the sample potentially comprises an enzyme capable of cleaving the umbelliferyl derivative and where the umbelliferyl derivative comprises an umbelliferyl core modified with one or more modifying moieties. | 2017-06-08 |
20170159106 | METHODS AND COMPOSITIONS FOR DETECTION OF SMALL RNAS - Currently, the circularization of small RNAs is broadly regarded as an obstacle in ligation-related assays and explicitly avoided while short lengths of linear RNA targets is broadly recognized as a factor limiting use of conventional primers in PCR-related assays. In contrast, the disclosed invention capitalizes on circularization of small RNA targets or their conjugates with oligonucleotide adapters. The circular RNA templates provide amplification of the target sequences via synthesis of multimer nucleic acids that can be either labeled for direct detection or subjected to PCR amplification and detection. Structure of small circular RNAs and corresponding multimeric nucleic acids provide certain advantages over current methods including flexibility in design of conventional RT and PCR primers as well as use of 5′-overlapping dimer-primers for efficient and sequence-specific amplification of short target sequences. Our invention also reduces number of steps and reagents while increasing sensitivity and accuracy of detection of small RNAs with both 2′OH and 2′-OMe at their 3′ ends. Our invention increase sensitivity and specificity of detection of microRNAs and other small RNAs with both 2′OH and 2′-OMe at their 3′ ends while allowing us to distinguish these two forms from each other. | 2017-06-08 |
20170159107 | UNHEATED EXTRACTION OF GENOMIC DNA IN AN AUTOMATED LABORATORY SYSTEM - A method for analyzing genomic DNA includes introducing a plurality of samples comprising human cells into individual vessels in each of a plurality of multi-vessel well plates. At least a subset of the human cells in the plurality of samples is lysed without the use of heat. DNA in the at least a subset of lysed human cells is isolated with the use of a plurality of paramagnetic beads. The isolated DNA is analyzed to identify one or more single nucleotide polymorphisms (SNPs), wherein the lysing, isolating, and analyzing steps are performed substantially in parallel for each of the plurality of samples. | 2017-06-08 |
20170159108 | MICROBIAL POPULATION ANALYSIS - The present invention relates to a method of typing a microbiome for having a desirable or undesirable signature, comprising analyzing the composition of the population of microorganisms in said microbiome based on taxonomic variation in the DNA sequence of the microbial 16S-23S rRNA internal transcribed spacer (ITS) regions in the genomic DNA of said microorganisms, wherein the sequences of conserved DNA regions comprised in the 16S and 23S rRNA sequences flanking said ITS region in the genome of said microorganisms comprise primer binding sites for amplification of said ITS regions. | 2017-06-08 |
20170159109 | METHODS AND COMPOSITIONS FOR NUCLEIC ACID ANALYSIS - The present invention is directed to methods, compositions and systems for analyzing sequence information while retaining structural and molecular context of that sequence information. | 2017-06-08 |
20170159110 | SEQUENCES AND THEIR USE FOR THE DETECTION AND CHARACTERIZATION OF E. COLI O157:H7 - This invention relates to a rapid method for detection and characterization of | 2017-06-08 |
20170159111 | FRET-LABELED COMPOUNDS AND USES THEREFOR - FRET-labeled compounds are provided for use in analytical reactions. In certain embodiments, FRET-labeled nucleotide analogs are used in place of naturally occurring nucleoside triphosphates or other analogs in analytical reactions comprising nucleic acids, for example, template-directed nucleic acid synthesis, DNA sequencing, RNA sequencing, single-base identification, hybridization, binding assays, and other analytical reactions. | 2017-06-08 |
20170159112 | AMPLIFIED ISOTHERMAL DETECTION OF POLYNUCLEOTIDES WITH ATP RELEASE - The presence of a target polynucleotide sequence of interest, including targets comprising genetic variations or a single nucleotide polymorphism, is detected by a DNA polymerization reaction, where the reaction mixture includes mixtures of nucleotides including at least one chimeric nucleoside tetraphosphate dimer ATP-linked nucleotide (ARN), in which ATP is the leaving group. DNA synthesis with ARNs is shown to be sequence specific, based on priming with a primer or template complementary to a target sequence. The released ATP is assayed in a qualitative or quantitative analysis, where one equivalent of ATP is released for every deoxynucleotide incorporated from an ARN. | 2017-06-08 |
20170159113 | METHODS AND COMPOSITIONS FOR DETECTION OF ANALYTES - The present invention relates to methods and compositions for detecting analytes, including proteins, polysaccharides, viruses, nucleic acids and cells. The methods and compositions utilize a reporter probe, suitably a multivalent reporter probe, to detect the presence of the analytes. In embodiments, the methods and compositions can be used for non-enzymatic detection of nucleic acids. | 2017-06-08 |
20170159114 | GENETIC POLYMORPHISMS IN AGE-RELATED MACULAR DEGENERATION - Methods for determining whether a patient is at increased risk of developing wet AMD or whether a patient has an increased likelihood of benefiting from treatment with a high-affinity anti-VEGF antibody. | 2017-06-08 |
20170159115 | SINGLE MOLECULE NUCLEIC ACID SEQUENCING WITH MOLECULAR SENSOR COMPLEXES - The present disclosure relates to methods and constructs for single molecule electronic sequencing of template nucleic acids. The constructs are molecular sensor complexes which comprise a processive nucleic acid processing enzyme localized to a nanopore. Conformational changes in the enzyme induced by single nucleic acid processing events are transduced into electric signals by the nanopore, which are used to identify individual nucleotides. The methods can include the steps of providing a membrane with the nanopore and the enzyme complexed with a template nucleic acid localized proximal to an opening in the pore, contacting the enzyme with an ion conductive reaction mixture including the reagents required for nucleic acid processing, providing a voltage drop across the pore that induces ion current through the pore that is modulated by conformational changes in the enzyme, measuring current through the pore over time to detect nucleotide-dependent conformational changes in the enzyme, and identifying the type of nucleotide processed by the enzyme using current modulation characteristics, thus determining sequencing information about the nucleic acid molecule. | 2017-06-08 |
20170159116 | MODULAR NUCLEOTIDE COMPOSITIONS AND USES THEREFOR - Nucleic acid compositions, methods of making and using such compositions that comprise modular functional groups that can be configured to provide desired functionality to different nucleotide types through a swappable and preferably non-covalent linkage component. Such compositions are useful in a variety of applications including nucleic acid analyses. | 2017-06-08 |
20170159117 | Nanopore-Based Single DNA Molecule Characterization, Identification and Isolation Using Speed Bumps - The present invention relates to a method of using nanopores to obtain sequence information of sample DNAs in ss test DNAs. The method comprises using speed bumps to stall the ss test DNAs in the nanopores at random positions of the ss test DNAs to obtain sequence information of each and every nucleotides of the sample DNAs, and to construct the whole sequences of the sample DNAs. The present invention also relates to identification and/or isolation of test DNAs having desired sequence(s) using nanopore detectors facilitated by speed bump. | 2017-06-08 |
20170159118 | SEQUENCING BY ORTHOGONAL SYNTHESIS - A method for sequencing includes steps of (a) providing first and second nucleic acid templates, wherein the two templates have different sequences; (b) extending a first primer bound to the first template using a first polymerase species and a first set of nucleotide analogs; (c) extending a second primer bound to the second template using a second polymerase species and a second set of nucleotide analogs, wherein the first polymerase species is different from the second polymerase species and wherein the first set of nucleotide analog is different from the second set of nucleotide analog, (d) detecting the first and second primer extension products; and (e) repeating steps (b) through (d), thereby determining the different sequences of the first and second templates. | 2017-06-08 |
20170159119 | METHODS AND COMPOSITIONS FOR LOADING OF POLYMERASE COMPLEXES - The present disclosure provides methods, compositions, and systems for distributing polymerase compositions into array regions. In particular, the described methods, compositions, and systems utilize density differentials and/or additives to increase efficiency in the distribution of polymerase compositions to a surface as compared to methods utilizing only diffusion control. | 2017-06-08 |
20170159120 | HIGH THROUGHPUT SCREENING OF POPULATIONS CARRYING NATURALLY OCCURRING MUTATIONS - Efficient methods are disclosed for the high throughput identification of mutations in genes in members of mutagenized populations. The methods comprise DNA isolation, pooling, amplification, creation of libraries, high throughput sequencing of libraries, preferably by sequencing-by-synthesis technologies, identification of mutations and identification of the member of the population carrying the mutation and identification of the mutation. | 2017-06-08 |
20170159121 | Genomic Regions with Epigenetic Variation That Contribute to Phenotypic Differences in Livestock - The invention provides compositions and methods for selecting milk-producing livestock with a preferred phenotype. In one embodiment, the method includes detecting methylation status of one or more genes and gene regulatory regions in a sample to identify the preferred phenotype. | 2017-06-08 |
20170159122 | METHODS AND KITS FOR DETECTING GENETIC MARKERS FOR LITTER SIZE IN PIGS - Methods and kits useful for identifying a pig as producing an increased litter size are provided. Genetic makers, in particular SNP markers are provided that are useful in distinguishing pigs for a phenotype associated with increased litter size. | 2017-06-08 |
20170159123 | MICRORNAS AS NEW THERAPEUTIC TARGETS FOR THE PREVENTION AND/OR TREATMENT OF RETINOPATHY - Methods and compositions are disclosed to identify plasma and vitreous microRNA (miRNA) signatures of diabetic retinopathy (DR), and then as diagnostic biomarkers for the onset and progression of DR. | 2017-06-08 |
20170159124 | EXAMINATION NOTIFICATION OUTPUT DEVICE, EXAMINATION NOTIFICATION OUTPUT METHOD, EXAMINATION NOTIFICATION OUTPUT PROGRAM, AND GENE CHROMOSOME EXAMINATION SYSTEM - There are provided an examination notification output device, an examination notification output method, an examination notification output program, and a gene chromosome examination system capable of outputting information, which is an indicator for determining whether or not a re-examination is required, in a case where it is determined that a re-examination is required for a gene chromosome examination. An examination notification output device that outputs an examination notification of a gene chromosome examination for examining the abnormalities of chromosomes included in embryonic cells includes: an information acquisition unit that acquires information including an examination result of a gene chromosome examination; an examination notification generation unit that generates an examination notification by adding re-examination necessity determination information that is used in determining whether or not a re-examination is required; and an examination notification output unit that outputs the generated examination notification. | 2017-06-08 |
20170159125 | MICRO-RNA BIOMARKERS FOR HAEMOLYSIS AND METHODS OF USING SAME - The present disclosure relates to micro-RNAs associated with haemolysis and methods of using them. One disclosed method is a procedure for identifying biological samples in which haemolysis is present by assessing the levels of expression of miRNA in the blood or another biological fluid. Also described is a method for identifying individuals at risk of having a disease or disorder associated with haemolysis. | 2017-06-08 |
20170159126 | GENE FOR PREDICTING THE PROGNOSIS FOR EARLY-STAGE BREAST CANCER, AND A METHOD FOR PREDICTING THE PROGNOSIS FOR EARLY-STAGE BREAST CANCER BY USING THE SAME - The present invention relates to a method for selecting a gene intended to predict the prognosis for a cancer, to the selected gene for predicting the prognosis of cancer and to a kit for predicting and a method for predicting metastasis in breast-cancer patients by using the same. In the present invention, a straight forward method is used to achieve high-reliability prediction of the patient's prognosis by analysing for the genetic characteristics of early stage breast cancer, and thus the present invention can be used to advantage in prognosis diagnosis which can reduce unnecessary anticancer therapy. | 2017-06-08 |
20170159127 | AN IN VITRO DIAGNOSTIC METHOD OF CANCER - The present invention relates to an in vitro method for the diagnosis, prognosis and treatment of cancer through the analysis in a body fluid sample of the total circulating DNA and the amount of DNA released by non-apoptic cells. | 2017-06-08 |
20170159128 | METHOD FOR SELECTING PERSONALIZED TRI-THERAPY FOR CANCER TREATMENT - The present invention relates to a method for determining the best combinations of at least three drugs for treating cancer, which is based on the determination of the most relevant intervention points for an individual. | 2017-06-08 |
20170159129 | METHODS FOR DETECTING TELOMERE MAINTENANCE MECHANISMS - Presented herein are methods for detecting the activity of alternative lengthening of telomeres, a telomere maintenance mechanism, by measuring relative G-rich and C-rich telomere DNA in a sample. Detection of ALT activity is accomplished with fluorescent probes that recognize G-strand and C-strand telomeric sequences, and fluorescent in-situ hybridization is used to measure the amounts of G-strand and C-strand DNA in a sample cell. The amounts of G-rich and C-rich telomere sequence in the sample cell is determined, relative to the same sequences in a standard, which may be a characterized cell line or a synthetic standard, such as a microbead with telomeric DNA attached. | 2017-06-08 |
20170159130 | TRANSCRIPTIONAL CLASSIFICATION AND PREDICTION OF DRUG RESPONSE (T-CAP DR) - A method to predict the response. e.g., a strong positive response or a strong lack of responsive, of myeloma cells of a multiple myeloma patient to a proteasome inhibitor is provided. | 2017-06-08 |
20170159131 | PREDICTING CANCER OUTCOME - This document provides methods and materials related to assessing prostate cancer in mammals. For example, this document provides nucleic acids and polypeptides that can be analyzed to determine whether a male mammal having prostate cancer is susceptible to a good or poor outcome. | 2017-06-08 |
20170159132 | DETECTING METHYLATION IN A SUBPOPULATION OF GENOMIC DNA - This invention provides methods of determining the biological, pathological, genetic, epigenetic or disease status in a biological sample by determining the methylation status of a subpopulation of genomic DNA in the sample. | 2017-06-08 |
20170159133 | MDM2-Containing Double Minute Chromosomes And Methods Therefore - Contemplated systems and methods allow for computational genomic analysis using paired-end sequence analysis and split read refinement to thereby identify high-confidence breakpoints associated with high copy numbers and orientation of rearrangements, which is then the basis for full reconstruction of double minutes (DM). In especially preferred aspects, the DM will also include an oncogene or tumor suppressor gene, and/or may be found in blood or blood derived fluids. | 2017-06-08 |
20170159134 | DNA-Based Method for Forensic Identification of Controlled Substances Using Plant DNA Markers - A method for determining the presence or absence of an illicit plant-derived compound in a sample. The method includes the steps of: (i) providing a sample potentially containing an illicit plant-derived compound; (ii) extracting DNA in the illicit plant-derived compound from the identified sample; (iii) amplifying, using PCR, the target plant DNA sequence from the extracted DNA; and (iv) detecting an amplified target plant DNA sequence, where detection of the amplified target plant DNA sequence indicates the presence of the illicit plant-derived compound. | 2017-06-08 |
20170159135 | LOW-LEAKAGE CELLULAR BIOSENSOR SYSTEM - The present invention is directed to a cellular biosensor system comprising (A) a repressor module comprising one or more genes, which in their cumulative gene action exert repressing and/or inhibitory effect(s) on (B), an output module comprising at least one gene comprising at least one output sequence generating one or more output signals (i) in the absence of repressing and/or inhibitory effect(s) of the repressor module (A) and (ii) in the presence of at least one recombinase expressed by (C), a recombinase module comprising at least one gene comprising at least one sequence encoding a site-specific recombinase that enables gene rearrangement in the output module resulting in one or more output signals in the absence of repressing and/or inhibitory effect(s) of the repressor module, wherein the repressing and/or inhibitory effects of the repressor module are controlled by one or more inputs that negatively affect the repressing and/or inhibitory effects of the repressor module (A). In addition, the present invention relates a biosensor network comprising the cellular biosensor system of the present invention and their uses in the diagnosis of a disease, for drug discovery, for biomanufacturing methods, for producing a transgenic animal, and for methods for the identification or classification of a cell status. | 2017-06-08 |
20170159136 | Methods for High-Throughput Labelling and Detection of Biological Features in situ Using Microscopy - Methods of labelling one or more subcellular components (e.g., an organelle and/or subcellular region) in vivo are provided. Methods of labelling a protein in vivo are provided. Methods of determining a nucleic acid sequence in situ are also provided. | 2017-06-08 |
20170159137 | METHODS FOR DETERMINING DRUG RESPONSE OF PATIENT SPECIFIC MUTATIONS - Methods for identifying and determining drug response of patient specific oncogenic mutations are provided. The methods provided identify specific (personalized) drug treatment based on the effect of drug on the patient derived markers associated with aberrant signal transduction pathways, in biological samples of a cancer patient. | 2017-06-08 |
20170159138 | METHODS AND SYSTEMS FOR DETERMINING ONCOGENIC INDEX OF PATIENT SPECIFIC MUTATIONS - Methods for determining various oncogenic-related indexes of patient specific mutations are provided. The methods provided allow determination and grading of various patient specific mutations and qualitative and quantitative determination of various related oncogenic indexes. | 2017-06-08 |
20170159139 | COMPOSITIONS AND METHODS FOR DETERMINING WHETHER A SUBJECT WOULD BENEFIT FROM CO-RECEPTOR INHIBITOR THERAPY - The present invention provides methods and compositions for determining whether a subject would benefit from co-receptor inhibitor therapy. In certain aspects, the methods can be used to determine whether a subject infected with a dual-mixed tropic population of HIV would benefit from CCCR5-inhibitor therapy or CXCR4-inhibitor therapy, the methods comprising determining whether the HIV population is a homogeneous or heterogeneous population of HIV, wherein the nature of the homogenous or heterogenous population of HIV indicates whether the patient would benefit from co-receptor inhibitor therapy. | 2017-06-08 |
20170159140 | PRODUCTION METHOD FOR MARAGING STEEL AND PRODUCTION METHOD FOR MARAGING STEEL CONSUMABLE ELECTRODE - The invention provides a maraging steel production method in which an oxide is added during an Mg oxide formation step, the production method including: the Mg oxide formation step in which Mg is added to molten steel and MgO is formed in the molten steel, during primary melting; a consumable electrode production step in which, after the Mg oxide formation step, the molten steel is solidified and a consumable electrode having residual MgO is obtained; and a vacuum arc re-melting step in which the consumable electrode is used and vacuum arc re-melting is performed. | 2017-06-08 |
20170159141 | FAR-INFRARED RADIATION MULTI-STAGE TYPE HEATING FURNACE FOR STEEL SHEETS FOR HOT STAMPING - An object of the present invention is to stably support steel sheets for hot stamping accommodated in a far-infrared radiation multi-stage type heating furnace over a long period of time using steel sheet support members having a small projected area and inhibited from thermally deforming. The far-infrared radiation multi-stage type heating furnace of the present invention includes: heating units and a ceiling unit arranged in a vertical direction with multiple stages to accommodate steel sheets for hot stamping that are aluminum-coated steel sheets or zinc-coated steel sheets; and far-infrared radiation heaters disposed within the heating units and the ceiling unit to heat the steel sheets for hot stamping to a temperature ranging from the Ac | 2017-06-08 |
20170159142 | Cooling Apparatus - A cooling apparatus includes a convoying unit and a spraying unit. The convoying unit includes a base and a plurality of rollers. The base includes a feeding end and a discharging end in which a convoying direction extends from the feeding end to the discharging end. The rollers are arranged on the base. Each roller includes a convoying portion. The convoying portion has a diameter which reduces from two ends to a center thereof. Each roller includes a shaft. The shaft has an axle direction which is at a diverted angle to the convoying portion. The diverted angle is 15° to 90°. The spraying unit includes at least one nozzle unit arranged between the feeding end and the discharging end. In this arrangement, a cooling operation can be performed on a rod-shaped steel material that is moving and rotating at the same time, attaining uniform and fast cooling effect. | 2017-06-08 |
20170159143 | Method for Manufacturing a High Strength Steel Sheet having Improved Formability and Ductility and Sheet Obtained - A method for manufacturing a high-strength sheet having improved formability and ductility accord which the chemical composition of the steel contains, in percent by weight: 0.25%2017-06-08 | |
20170159144 | METHOD FOR IMPROVING AN IRON-NICKEL-CHROMIUM-MANGANESE ALLOY FOR TIMEPIECE APPLICATIONS - Method for improving an iron-nickel-chromium-manganese alloy for timepiece applications, particularly for producing a balance spring, where a base alloy is chosen and produced, comprising by mass:
| 2017-06-08 |
20170159145 | METHOD FOR FABRICATION OF A TIMEPIECE BALANCE SPRING - Method for fabrication of an antiferromagnetic and temperature compensated timepiece balance spring, including the steps of:
| 2017-06-08 |
20170159146 | Tubular Strengthening and Patterning Method for Enhanced Heat Transfer - A process for hardening tubulars and increasing their surface area for heat transfer can be performed in place in a borehole or on the surface. A pattern is applied to an interior wall with at laser, electron beam or radiation source that is remotely controlled to apply the hardening pattern to the inside or outside wall as inert gas or clean fluid is applied. Pressure differential is applied to the wall so that the non-hardened portions or the negative of the hardened pattern plastically or elastically deform to increase surface area and enhance load resistance of tubular or sheets. Alternatively, wall differential pressure is applied with an insert having a raised pattern on its exterior surface causing the spaces where the pattern is absent to plastically deform to enhance surface area. When done in a borehole annulus pressure or stand pipe pressure is applied or a vacuum is pulled inside the tubular to generate differential pressure for hydro-forming or switching dents in an opposite stable condition. The insert can be removed mechanically, or by dissolving or disintegration. Geothermal and SAGD applications are envisioned. | 2017-06-08 |
20170159147 | A TIRE RASP BLADE - Methods and apparatus for treating a shaped tire rasp blade for mounting on a rasp hub, said tire rasp blade comprising a blade body and blade teeth, wherein the method comprises an austenitising process for austenitising the main part of the tire rasp blade by heating it to an austenitisation temperature, a subsequent quenching process and finally a tempering process for tempering the tire rasp blade. The austenitising process is performed by using induction heating for heating of said tire rasp blade, increasing the durability of a rasp blade by 30-50%. Induction heating is fast (austenitisation temperature can be reached within 15 seconds), wherein energy is focused into the rasp blade, enabling austenitisation temperature to be reached quite fast throughout the entire rasp blade. | 2017-06-08 |
20170159148 | SEAL RINGS COMPRISING CHROMIUM AND BORON CAST IRON - A seal ring comprising a chromium and boron containing cast iron alloy composition is disclosed. The cast iron alloy composition comprises each of boron, chromium and silicon in the following amounts: boron up to 1.5 wt. %; chromium from 8 to 14 wt. %; and silicon up to 3.0 wt. %. The seal ring may be produced by melting a cast iron composition further comprising the foregoing alloying elements; pouring the melted alloy into a mold; cooling the melted alloy to form a cast iron seal ring; and separating the cast iron seal ring from the mold. The seal ring is typically used in the undercarriage of earth-working machines, such as in the drive train or power train of such machines. | 2017-06-08 |
20170159149 | HOT-ROLLED STEEL SHEET AND PRODUCTION METHOD OF THEREFOR - A hot-rolled steel sheet has predetermined chemical composition, a sum of a Si content and an Al content is higher than 0.20% and lower than 0.81%, a microstructure includes, by area fraction, 90% to 99% of a ferrite, 1% to 10% of a martensite, and a bainite limited to 5% or less, the grain size of the martensite is 1 to 10 μm, the X-ray random intensity ratio of a {211}<011> orientation which is parallel to a rolled surface of the steel sheet and is parallel to a rolling direction is 3.0 or less. | 2017-06-08 |
20170159150 | FAR -INFRARED RADIATION MULTI-STAGE TYPE HEATING FURNACE FOR STEEL SHEETS FOR HOT STAMPING - Provided is a far-infrared radiation multi-stage type heating furnace for steel sheets for hot stamping, the furnace including far-infrared radiation heaters having flexibility that are prevented from deflecting even during heating at temperatures ranging from the Ac | 2017-06-08 |
20170159151 | METHOD FOR MANUFACTURING HIGH-STRENGTH GALVANIZED STEEL SHEET - A method for manufacturing a high-strength galvanized steel sheet. The method includes a first heating step of holding the steel sheet in a temperature range of 750° C. to 880° C. for 20 s to 600 s in an atmosphere having an H | 2017-06-08 |
20170159152 | APPARATUSES AND METHODS FOR PROCESSING A METAL RIBBON - An apparatus ( | 2017-06-08 |
20170159153 | LEACHING AIDS AND METHODS OF USING LEACHING AIDS - Leaching aids, for example, when present in a leaching solution, and methods of using the leaching aids. The leaching aids can include one or a combination of compounds. The method of using the leaching aids can include a process of recovering metal from ore, for example, a process involving heap leaching, solvent extraction and electrowinning. | 2017-06-08 |
20170159154 | METHOD FOR PRODUCING INTERMETALLIC COMPOUND - A metal paste that includes a metal component and a flux. The metal component includes a first metal powder and a second metal powder. The first metal powder is Sn. The second metal powder is a CuNi alloy. The metal paste is heated for a time t1 to a temperature T1 where the first metal powder is melted. Next, the metal paste is heated for a time t2 longer than the time t1 at a temperature T2 lower than the temperature T1 to produce an intermetallic compound from the first metal Sn and the second metal CuNi alloy. | 2017-06-08 |
20170159155 | Nb-Silicide Based Composites, High-Temperature Component and High-Temperature Heat Engine Employing the Same - To provide a Nb-silicide based composite achieving both mechanical characteristics and toughness at high levels in an ultrahigh temperature region (1200° C. or more) as well as a high-temperature component and a high-temperature heat engine which employ the same. The Nb-silicide based composite according to the present invention includes 13 to 23 at % of Si, 2.0 to 10 at % of Cr, 5.0 to 23 at % of Ti, 0.0 to 6.0 at % of Al, 0.10 to 8.0 at % of Zr, 1.0 to 8.0 at % of Hf, 0.0 to 2.0 at % of W, 0.10 to 6.0 at % of Sn, 3.1 to 8.0 at % of Mo, 0.20 to 5.0 at % of B, and the balance being Nb and inevitable impurities. | 2017-06-08 |
20170159156 | IRON-BASED ALLOY COATING AND METHOD FOR MANUFACTURING THE SAME - A method of manufacturing an iron-based alloy coating is provided, which includes (a) providing an iron-based alloy powder having a chemical formula of Fe | 2017-06-08 |
20170159157 | ULTRA-HIGH-STRENGTH AND ULTRA-HIGH-TOUGHNESS OIL CASING AND MANUFACTURING METHOD THEREOF - There is disclosed an ultrahigh strength and ultrahigh toughness oil casing pipe, comprising the following chemical elements in mass percentages: C: 0.12-0.18%; Si: 0.1-0.4%; Mn: 1.1-1.6%; Cr: 0.1-0.4%; Mo: 0.2-0.5%; Nb: 0.02-0.04%; Ti: 0.02-0.05%; B: 0.0015-0.005%; Al: 0.01-0.05%; Ca: 0.0005-0.005%; N≦0.008%; with the proviso of 0<(Ti—3.4N)≦0.02%, Ti/B≧10; and the balance of Fe and other unavoidable impurities. The strength of the oil casing pipe can be equal to or higher than 150 ksi steel grade, and the zero degree lateral Charpy impact work is not less than 10% of the yield strength of the 150 ksi steel grade. | 2017-06-08 |
20170159158 | ULTRA-HIGH-STRENGTH SPRING STEEL - An ultra-high-strength spring steel, for use as a valve spring steel in a vehicle engine, includes 0.5 to 0.7% by weight of C, 1.2 to 1.5% by weight of Si, 0.6 to 1.2% by weight of Mn, 0.6 to 1.2% by weight of Cr, 0.1 to 0.5% by weight of Mo, 0.05 to 0.8% by weight of Ni, 0.05 to 0.5% by weight of V, 0.05 to 0.5% by weight of Nb, 0.05 to 0.3% by weight of Ti, 0.3% or less by weight of Cu (but not 0%), 0.0001 to 0.3% by weight of Al, 0.03% or less by weight of N (but not 0%), 0.0001 to 0.003% by weight of O, and a remainder of Fe and other unavoidable impurities, based on 100% by weight of the ultrahigh-strength spring steel. | 2017-06-08 |
20170159159 | COIL SPRING STEEL - a coil spring steel which includes: 0.4 to 0.9 wt % of carbon (C); 1.3 to 2.3 wt % of silicon (Si), 0.5 to 1.2 wt % of manganese (Mn); 0.1 to 0.5 wt % of molybdenum (Mo); 0.05 to 0.80 wt % of nickel (Ni); 0.05 to 0.50 wt % of vanadium (V); 0.01 to 0.50 wt % of niobium (Nb); 0.05 to 0.30 wt % of titanium (Ti); 0.6 to 1.2 wt % of chromium (Cr); 0.0001 to 0.3 wt % of aluminum (Al); less than or equal to 0.3 wt % but greater than 0% of copper (Cu); less than or equal to 0.3 wt % but greater than 0% of nitrogen (N); 0.0001 to 0.0030 wt % of oxygen (O); and a balance of iron (Fe) and unavoidable impurities. | 2017-06-08 |
20170159160 | ULTRA HIGH-STRENGTH SPRING STEEL - A steel composition is provided and includes carbon of about 0.5 to 0.7 wt %; silicon of about 1.3 to 2.3 wt %; manganese of about 0.6 to 1.2%; chromium of about 0.6 to 1.2 wt %; molybdenum of about 0.1 to 0.5 wt %; nickel of about 0.05 to 0.8 wt %; vanadium of about 0.05 to 0.5 wt %; niobium of about 0.05 to 0.5 wt %; titanium of about 0.05 to 0.3 wt %; cobalt of about 0.01 to 3 wt %; zirconium of about 0.001 to 0.2 wt %; yttrium of about 0.01 to 1.5 wt %; copper of about 0.3% or less but greater than 0 wt %; aluminum of about 0.3% or less but greater than 0 wt %; nitrogen of about 0.03% or less but greater than 0 wt %; oxygen of about 0.003% or less but greater than 0 wt %. Additionally, a balance iron, based on the total weight is included. | 2017-06-08 |
20170159161 | ULTRA-HIGH-STRENGTH SPRING STEEL FOR VALVE SPRING - An ultra-high-strength spring steel for an engine valve spring steel comprises, by weight: 0.5-0.7% of carbon (C), 1.3-2.3% of silicon (Si), 0.6-1.2% of manganese (Mn), 0.6-1.2% of chrome (Cr), 0.1-0.5% of molybdenum (Mo), 0.05-0.8% of nickel (Ni), 0.05-0.5% of vanadium (V), 0.05-0.5% of niobium (Nb), 0.05-0.3% of titanium (Ti), 0.001-0.01% of boron (B), 0.01-0.52% of tungsten (W), 0.3% or less (0% exclusive) of copper (Cu), 0.3% or less (0% exclusive) of aluminum (Al), 0.03% or less (0% exclusive) of nitrogen (N), 0.003% or less (0% exclusive) of oxygen (O), and a remainder of Fe and other inevitable impurities, based on 100% by weight of the ultra-high-strength spring steel. | 2017-06-08 |
20170159162 | METHODS FOR PROCESSING NICKEL-BASE ALLOYS - A method for heat treating a powder metallurgy nickel-base alloy article comprises placing the article in a furnace at a start temperature in the furnace that is 80° C. to 200° C. below a gamma prime solvus temperature, and increasing the temperature in the furnace to a solution temperature at a ramp rate in the range of 30° C. per hour to 70° C. per hour. The article is solution treated for a predetermined time, and cooled to ambient temperature. | 2017-06-08 |
20170159163 | PLASMA COATING DEVICE AND METHOD FOR PLASMA COATING OF A SUBSTRATE - The invention relates to a plasma coating device ( | 2017-06-08 |
20170159164 | SURFACE COATING TREATMENT - A method for conditioning a ceramic layer with a thickness of less than 150 μm over a substrate is provided. The ceramic layer is cleaned. A region of the ceramic layer is scanned with a pulsed excimer laser beam at a repetition rate of 3-300 Hz. | 2017-06-08 |