24th week of 2015 patent applcation highlights part 33 |
Patent application number | Title | Published |
20150160151 | Formulation and Storage Method to Enhance the Enzyme and Sensor Stabilities - An analyte sensor and method of making are provided. The analyte sensor includes a crosslinked, hydrophilic copolymer in contact with a surface of an electrode; and an analyte sensing component embedded within the crosslinked, hydrophilic copolymer, where the analyte sensing component is surrounded by a buffer having a predetermined buffering component and pH value and where the crosslinked, hydrophilic copolymer includes: backbone chains having first methacrylate-derived units, each having a first hydrophilic side chain; second methacrylate-derived units, each having a second hydrophilic side chain, where the first and second side chains are the same or different; third methacrylate-derived units; and hydrophilic crosslinks between third methacrylate-derived units in different backbone chains. The analyte sensor may be maintained at a humidity level of less than 25% to maintain its performance during storage. | 2015-06-11 |
20150160152 | ELECTRODE FOR SUPEROXIDE ANION AND SENSOR INCLUDING THE SAME - An electrode for superoxide anions characterized by comprising a conductive component and, superimposed on a surface thereof, a film resulting from electrolytic polymerization of a metal thiofurylporphyrin/axial ligand complex; and a sensor for measuring a superoxide anion concentration including the same. The electrode for superoxide anions, by virtue of not only the excellent performance of electrode provided with the metal porphyrin complex polymer film, but also the presence of the axial ligand, can prevent poisoning by a catalyst poison such as hydrogen peroxide. Accordingly, in any of in vitro or in vivo environments, this electrode for superoxide anions enables detection of superoxide anion radicals without suffering any influence from a catalyst poison such as hydrogen peroxide. Moreover, quantitative assay of superoxide anions can be performed by the use of this electrode for superoxide anion in combination with a counter electrode or a reference electrode. Thus, this electrode for superoxide anions can find wide applicability in various fields. | 2015-06-11 |
20150160153 | System and Method for Forming Microwells - A method of forming a sensor component includes forming a first layer over a sensor pad of a sensor of a sensor array. The first layer includes a first inorganic material. The method further includes forming a second layer over the first layer. The second layer includes a polymeric material. The method also includes forming a third layer over the second layer, the third layer comprising a second inorganic material; patterning the third layer; and etching the second layer to define a well over the sensor pad of the sensor array. | 2015-06-11 |
20150160154 | INTEGRATED SENSOR ARRAYS FOR BIOLOGICAL AND CHEMICAL ANALYSIS - The invention is directed to apparatus and chips comprising a large scale chemical field effect transistor arrays that include an array of sample-retaining regions capable of retaining a chemical or biological sample from a sample fluid for analysis. In one aspect such transistor arrays have a pitch of 10 μm or less and each sample-retaining region is positioned on at least one chemical field effect transistor which is configured to generate at least one output signal related to a characteristic of a chemical or biological sample in such sample-retaining region. In one embodiment, the characteristic of said chemical or biological sample is a concentration of a charged species and wherein each of said chemical field effect transistors is an ion-sensitive field effect transistor having a floating gate with a dielectric layer on a surface thereof, the dielectric layer contacting said sample fluid and being capable of accumulating charge in proportion to a concentration of the charged species in said sample fluid. In one embodiment such charged species is a hydrogen ion such that the sensors measure changes in pH of the sample fluid in or adjacent to the sample-retaining region thereof. Apparatus and chips of the invention may be adapted for large scale pH-based DNA sequencing and other bioscience and biomedical applications. | 2015-06-11 |
20150160155 | ELECTROPHORESIS GEL CASSETTE AND A MTHOD OF FILLING AN ELECTROPHORESIS GEL CASSETTE - Electrophoresis gel cassette comprising a cassette housing defining a gel compartment for molding a gel member wherein the gel compartment comprises a fill port at an inlet end of the gel compartment and one or more over-fill ports at a distal end of the gel compartment with respect to a filling direction, and wherein the over-fill port(s) is arranged in fluidic communication with an overfill chamber. | 2015-06-11 |
20150160156 | CASSETTE FOR ELECTROPHORESIS AND ELECTROPHORESIS METHOD - To easily introduce a sample into a sample separation medium without formation of a well in the sample separation medium, a cassette ( | 2015-06-11 |
20150160157 | SCANNING PROBE WITH TWIN-NANOPORE OR A-SINGLE-NANOPORE FOR SENSING BIOMOLECULES - A mechanism is provided for sensing molecules. A twin-nanopore probe includes a first channel and a second channel. A first pressure-controlled reservoir is connected to the first channel to generate a positive pressure. A second pressure-controlled reservoir is connected to the second channel to generate a negative pressure. A container includes ionic solvent with molecules, and a tip of the twin-nanopore probe is submerged in the container of the ionic fluid with the molecules. The first channel, the second channel, the first pressure-controlled reservoir, and the second pressure-controlled reservoir are filled with the ionic fluid. The first pressure-controlled reservoir drives the ionic fluid out of the first channel and the second pressure-controlled reservoir draws in the ionic fluid with the molecules and solvent through the second channel. A flow of ionic current in the twin-nanopore probe is measured to differentiate the molecules that flow through the second channel. | 2015-06-11 |
20150160158 | ELECTROPHORESIS INSTRUMENT, ELECTROPHORESIS DEVICE, SAMPLE INTRODUCTION METHOD, AND SAMPLE SEPARATION METHOD - There is provided an electrophoresis instrument capable of easily performing a separation of a biological sample by isoelectric focusing with excellent reproducibility. | 2015-06-11 |
20150160159 | DNA SEQUENCING USING MULTIPLE METAL LAYER STRUCTURE WITH DIFFERENT ORGANIC COATINGS FORMING DIFFERENT TRANSIENT BONDINGS TO DNA - A nanodevice includes a reservoir filled with conductive fluid and a membrane separating the reservoir. A nanopore is formed through the membrane having electrode layers separated by insulating layers. A certain electrode layer has a first type of organic coating and a pair of electrode layers has a second type. The first type of organic coating forms a motion control transient bond to a molecule in the nanopore for motion control, and the second type forms first and second transient bonds to different bonding sites of a base of the molecule. When a voltage is applied to the pair of electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels via the first and second transient bonds formed to be measured as a current signature for distinguishing the base. The motion control transient bond is stronger than first and second transient bonds. | 2015-06-11 |
20150160160 | DUAL-PORE DEVICE - Provided is a device comprising an upper chamber, a middle chamber and a lower chamber, wherein the upper chamber is in communication with the middle chamber through a first pore, and the middle chamber is in communication with the lower chamber through a second pore, wherein the first pore and second pore are about 1 nm to about 100 nm in diameter, and are about 10 nm to about 1000 nm apart from each other, and wherein each of the chambers comprises an electrode for connecting to a power supply. Methods of using the device are also provided, in particular for sequencing a polynucleotide. | 2015-06-11 |
20150160161 | Substances Detection System and Method - A system and methodology for the detection of threat substances is described. The detector system consists of a method to evaporate the sample into a primary separator and thermal release of trapped target materials into a secondary separator like conventional GC. The GC column is thermally ramped to elute all substances and the end of the column terminates into an atmospheric pressure chemical ionization source of an axial ion mobility spectrometer (AIMS). Both polarity ions are pulsed into a single construction separator tube at different timing. Their arrival time is detected on a collector plate, which allows registering their ion mobility spectra of both polarities for a single GC peak. | 2015-06-11 |
20150160162 | USER INTERFACES, SYSTEMS AND METHODS FOR DISPLAYING MULTI-DIMENSIONAL DATA FOR ION MOBILITY SPECTROMETRY-MASS SPECTROMETRY - A user interface, and related systems and methods, are provided for displaying multi-dimensional spectrometric data obtained from IMS-MS operations. The user interface displays such data in alternative data plots, such as drift spectra, mass spectra, and multi-dimensional maps. Different plots may be dynamically linked to each other, enabling a user to select a data range or ranges in one plot and consequently cause other plots to be updated, changed, or replaced, or new plots to be extracted or generated, in accordance with the selected data range or ranges. | 2015-06-11 |
20150160163 | Hydrogen Concentration Meter - A hydrogen concentration meter for measuring density of hydrogen in gas, is disclosed having a first electrode and a second electrode. The first electrode is formed of a first metal. The second electrode is formed of a second metal having a work function different from a work function of the first metal. The second electrode faces the first electrode. At least one of the first electrode or the second electrode detects an electrically charged particle generated electrically between the first electrode and the second electrode by a recoil proton generated by an irradiated neutron. | 2015-06-11 |
20150160164 | SYSTEM AND METHOD FOR INSPECTION OF COMPONENTS - An automatic portable inspection system includes a part holder for holding a component to be inspected and a rotary actuator coupled to the part holder. The system further includes an eddy current probe for scanning the component and providing eddy current signals. The system also includes a self-alignment unit coupled to the eddy current probe and configured to align an axis of the probe substantially perpendicular to a surface of the component and to maintain constant contact with said surface of the component. The system also includes a linear actuator coupled to the self-alignment unit, for providing movement of the eddy current probe along the X, Y and Z axes. A motion control unit is coupled to the rotary actuator and the linear actuator, for controlling the rotary actuator and the linear actuator for moving said probe about the component in accordance with a scan plan. | 2015-06-11 |
20150160165 | Method and Device for Detecting Odorants in Hydrocarbon Gases - A quartz crystal microbalance (QCM) is disclosed for use in a hand-held detection device for detecting the presence of an odorant in hydrocarbon gaseous fuels. The odorant is a thiol-based compound, such as ethanethiol. The QCM is coated with a coating typically containing a reagent that specifically reacts with the thiol of the odorant and alters its oscillation frequency as a result of mass gained in the reaction. Signal measurement and processing circuitry is provided for monitoring the change in oscillation frequency, for nulling out the effect of interfering compounds, and for reporting out the result. | 2015-06-11 |
20150160166 | NON-DESTRUCTIVE ULTRASOUND TESTING OF STRUCTURES MADE OF COMPOSITE MATERIAL - The invention relates to a diagnostic apparatus | 2015-06-11 |
20150160167 | ULTRASONIC INSPECTION DEVICE AND METHOD - An ultrasonic transmitter | 2015-06-11 |
20150160168 | LIGHT SOURCE UNIT AND PHOTOACOUSTIC MEASUREMENT APPARATUS USING THE SAME - It is desirable to more stably and efficiently transmit light in a housing of a light source unit. A light source unit | 2015-06-11 |
20150160169 | METHOD AND SYSTEM FOR MULTI-PATH ACTIVE DEFECT DETECTION, LOCALIZATION AND CHARACTERIZATION WITH ULTRASONIC GUIDED WAVES - A method and system of detecting, localizing, and characterizing a defect at one or more spatial points of interest on a structure. The method may include collecting first data in a first state using one or more transducers on the structure, collecting second data in a second state subsequent to the first state, computing a scattered impulse response based on the collected first data and the collected second data, comparing the scattered impulse response with an estimated scattered impulse response corresponding to the case when damage is present at one or more spatial points of interest on the structure, and combining the generated comparison results to detect, localize, and characterize a defect at the one or more spatial points of interest on the structure. | 2015-06-11 |
20150160170 | CHROMATOGRAPHY COLUMN DISTRIBUTION SYSTEM - A chromatography column distribution system includes a set of first bed support ribs extending radially from an inner, first radial position near the centre of the plate to an outer radial position nearer to the periphery of the plate and at least one set of intermediate bed support ribs starting at an intermediate radial position and extending to an outer radial position nearer to the periphery of the plate. Channels are formed between adjacent bed support ribs. The desired local effective channel height varies in accordance with a predetermined formula from the first radial position to the outer radial position. The transverse cross-sectional areas of the ribs or the channels are adapted such that the actual local effective channel height is within 15% of the desired local effective channel height over portions of the distribution system situated between the first radial position and the outer radial position. The length of the portions correspond to at least 80% of the distance between the first and outer radial position and the outer radial position. | 2015-06-11 |
20150160171 | Automated Quality Control System for Radiopharmaceuticals - An automated HPLC-based quality control system to perform quality control testing on a radiopharmaceutical solution shortly after synthesis. An automated HPLC-based quality control system makes efficient use of sample volume and is compatible with a variety of radioisotopes and radiopharmaceutical compounds. In several embodiments, the automated nature of an automated HPLC-based quality control system allows for quality control tests to be conducted quickly and with minimal impact on user workflow. When used as part of an integrated PET biomarker radiopharmaceutical production system, the present general inventive concept permits a manufacturer to produce product and conduct quality control tests with lower per dose costs and shorter testing times. | 2015-06-11 |
20150160172 | Double-sided Diaphragm Micro Gas-preconcentrator with a Back-on-face Configuration - A double-sided diaphragm micro gas-preconcentrator has a micro-gas chamber which is formed by stacking an upper silicon substrate with a lower silicon substrate with a back-on-face configuration. One or more suspended membranes are provided on every silicon substrate. The silicon where the suspended membrane is provided is completely removed for forming a cavity. A thin-film heater is deposited on every suspended membrane. A sorptive film is coated on an inner wall of every suspended membrane. Thus, the upper and lower sides of the preconcentrator in the present invention are suspended membranes, which improve the area of the sorptive film on the diaphragm. As a result, the preconcentrating factor is improved while keeping the small heat capacity, fast heating rate, and low power consumption features of the planar diaphragm preconcentrator. | 2015-06-11 |
20150160173 | THIN LAYER CHROMATOGRAPHY PLATES AND RELATED METHODS - In an embodiment, a method for manufacturing a thin layer chromatography (“TLC”) plate is disclosed. The method includes forming a layer of elongated nanostructures (e.g., carbon nanotubes), and at least partially coating the elongated nanostructures with a coating including silicon nitride. At least a portion of the elongated nanostructures may be removed after being coated. The silicon nitride of the coating may be at least partially oxidized to form silicon dioxide. | 2015-06-11 |
20150160174 | SYSTEM AND METHOD FOR FLEXIBLE FUEL ETHANOL CONCENTRATION AND HARDWARE MALFUNCTION DETECTION - A system and method for flexible fuel ethanol concentration and hardware malfunction detection compares a current hardware reference value learned based on an air-fuel ratio detected during a pre-fuel mix period with a previous hardware reference value from a previous vehicle driving cycle, and detects a hardware malfunction when a difference between current and previous hardware reference values exceeds a predetermined threshold. The system and method also monitors the air-fuel ratio during a post-fuel mix period, and detects a hardware malfunction when the air-fuel ratio changes by more than a predetermined threshold during the post-fuel mix period. The system and method also compares an observed slope of the air-fuel ratio detected during a fuel mixing period over an amount of fuel consumed with an expected slope when a cold-start is detected, and detects a hardware malfunction when a difference between observed and expected slopes exceeds a predetermined threshold. | 2015-06-11 |
20150160175 | PARTICLE DETECTOR, SYSTEM AND METHOD - The invention provides use of one or more emitted beams of radiation ( | 2015-06-11 |
20150160176 | Apparatus and Method for Testing Medicaments - Apparatus for testing the solubility of a medical dosage form includes a chamber ( | 2015-06-11 |
20150160177 | METHOD OF MEASURING A PHYSICAL PROPERTY OF A SOLID BODY - A method of measuring a physical property of a solid body is provided. The method includes remotely deploying a measurement device into a body of ice prone water. The method also includes embedding the measurement device within an ice pack newly formed within the body of ice prone water. The method further includes storing data of the physical property within the measurement device. | 2015-06-11 |
20150160178 | UNIVERSAL WATER CONDITION MONITORING DEVICE - The present invention is directed to a water condition monitoring device and related methods of use that significantly reduce the cost of the water condition monitoring devices by replacing the expensive and bulky multiple sensor electrodes of currently available devices with a single set of two or three metal electrodes to detect and/or measure such water quality parameters as pH, electric conductivity, temperature, and dissolved oxygen content. A microcontroller activates each sensor one at a time in a continuous loop, processing the sensor signals into near real time water condition data, which may be stored, displayed, or sent to a remote location for storage or display. | 2015-06-11 |
20150160179 | Method for Determining the Concentration of Iron Ions in Hydrocarbon Compositions - The present invention relates to a method for determining the concentration of iron ions in a hydrocarbon composition, as well as reagents and kits for use in such methods. The method utilises a thiocarboxylic acid having formula (I) which reduces the ferric ions and complexes ferrous ions producing a colored solution, which can be analysed to determine the amount of iron ions in the starting sample. | 2015-06-11 |
20150160180 | SENSOR STRUCTURE FOR EVAP HYDROCARBON CONCENTRATION AND FLOW RATE - A system and method controls a ratio of fuel to gas delivered to an internal combustion engine. Fuel for the engine is stored in a fuel supply. The fuel supply generates fuel vapor that is retained in a canister. The canister is in fluid communication with the engine via a flow path. Hydrocarbon concentration of fuel vapor in the flow path is determined. Pressure drop across a restrictive orifice provided in the flow path is measured to determine a flow rate of the fuel vapor in the flow path. A flow of the fuel vapor through the flow path and to the engine is controlled and injection valves that inject fuel into the engine are controlled so that an amount of fuel injected into the engine is based on the determined concentration of hydrocarbons in the fuel vapor. | 2015-06-11 |
20150160181 | EXPLOSIVE MATERIAL DETECTION - A system for detecting explosive materials. The system includes radiated high power electromagnetic radiation at one or more frequencies in the millimeter wave spectrum or above to interact with a sample and be reflected therefrom. The system also includes at least one electromagnetic sensor to measure emissions at harmonic frequencies and characteristics unique to one or more explosive materials. The system also includes a processor to collate and maintain a lookup table to identify specific explosive material types. | 2015-06-11 |
20150160182 | SOIL-WATER-AIR COUPLED ANALYZER, SOIL-WATER-AIR COUPLED ANALYZING METHOD AND SOIL-WATER-AIR COUPLED ANALYZING PROGRAM - Soil-water-air coupled analyzing computes various matrices with respect to a time rate of volume change of a soil skeleton, tangent stiffness and water permeability, air permeability, moisture characteristic and mass of soil, based on the settings of soils such as clay, intermediate soil and sand with regard to respective soil elements of a soil foundation, settings of a solid soil model and settings of analysis conditions, establishes simultaneous equations using these matrices, provides a boundary condition regarding deformation, a stress rate or the like, a hydraulic condition regarding pore water and an air boundary condition regarding pore air and determines solutions of unknown “jerk field”, pore water pressure field and pore air field. This enables the soil foundation made of any type of soil in any state to be analyzed with high accuracy. | 2015-06-11 |
20150160183 | Diamine-Based Oil Marker Compositions and Method of Identifying Oil Product Using the Same - Provided is a method of identifying authenticity of oil by reacting oil marked by a Oil Marker Composition with a developer to develop a color and then measuring absorbance. According to the present invention, an oil maker capable of quantitatively and qualitatively measuring authenticity of oil due to a rapid reaction rate, excellent reproducibility, and distinct color development that may be observed by the naked eyes, and a method of identifying oil using the same. | 2015-06-11 |
20150160184 | METHOD OF EASILY IDENTIFYING LUBRICATING OILS, IDENTIFICATION KIT AND LUBRICATING OILS THAT CAN BE EASILY IDENTIFIED - Method for the identification of a lubricating oil composition, characterised in that it comprises the following steps: a heating process to heat the lubricating oil composition which is the target of the investigation and which has the possibility of containing a volatile amine as a marker; after the heating process, a first reaction process which disposes into a vapour phase on top of the liquid surface of the lubricating oil composition a medium which contains an amine colouring reagent to be used in at least one kind of amine-based colouring reaction selected from a group comprised of quinhydrone reactions, ninhydrin reactions and Dragendorff reactions; after the heating process, a second reaction process which disposes into a vapour phase on top of the liquid surface of the lubricating oil composition a medium which contains a pH-dependent colouring reagent to be used in a pH-dependent colouring reaction; and an evaluation process in which the lubricating oil composition which is the target of the investigation is assessed as to whether or not it is a specific lubricating oil composition by at least comparing a standard colouring pattern, in which a first colouring pattern attributable to the reaction or non-reaction of an amine colouring reagent and a volatile amine and a second colouring pattern attributable to the reaction or non-reaction of a pH-dependent colouring reagent and a volatile amine are displayed, with a colouring pattern which is the result of the first reaction process and the second reaction process. | 2015-06-11 |
20150160185 | METHOD FOR CONTROLLING ELECTRODES FOR BIO-IMPEDANCE MEASUREMENTS AND APPARATUS FOR BIO-IMPEDANCE MEASUREMENTS - Method for Controlling Electrodes for Bio-impedance Measurements and Apparatus for Bio-impedance Measurements There is provided a control circuit for electrodes in a bio-impedance measurement system, the bio-impedance measurement system comprising screening current injecting electrodes and measuring current injecting electrodes, the control circuit comprising: a current generator for connection to at least one screening current injecting electrode; and an measuring signal output configured to establish a measuring potential between the measuring current injecting electrodes, wherein the control circuit is configured such that the measuring potential is dependent on a measure of a potential difference resulting from the screening current. The control circuit uses the value of the potential resulting from the screening current to determine the potential difference between the measuring current injecting electrodes. In this way the flow of measuring current can be made smaller than the screening current and necessarily at a safe level. | 2015-06-11 |
20150160186 | Diabetic Testing Supply Dispenser - Single-use and refillable diabetic testing supply dispensers are disclosed. In various embodiments, the dispenser uses an ejector coupled to an actuator external to the dispenser to move single testing supplies contained within the internal volume of the dispenser through a port in the dispenser for selection by the user. In various embodiments the dispenser has a dispenser head unit that is coupled to one of a variety of magazine designs which store the testing supplies to be dispensed. A bulk loader rapidly refills the dispenser. In some embodiments, testing supplies are affixed to a carrier strip which is carried on a spool internal to the dispenser, incremented out of the dispenser, and cut to dispense a single testing supply during each operation. In some embodiments, tamper resistant elements are added to discourage fraudulent resale of the testing supplies contained in the dispenser. In some embodiments, the dispenser includes a lancing device that is fed by a magazine and deters re-use of lancets. | 2015-06-11 |
20150160187 | APPARATUS AND METHODS FOR REDUCING ELECTRICAL SHOCK HAZARD FROM BIOSENSOR METERS - A biosensor meter ( | 2015-06-11 |
20150160188 | Method for Flagging a Sample - A hematology analyzer is provided. In certain embodiments, the hematology analyzer comprises: a) a flow cell; b) a light source for directing light to the flow cell; c) a plurality of detectors for detecting a plurality of optical characteristics of a blood cell passing through the flow cell; and d) a data analysis workstation programmed to: i. enumerate test blood cells passing through the flow cell; and ii. flag a blood sample as containing lysis-resistant red blood cells or fragile white blood cells. | 2015-06-11 |
20150160189 | Method for Discriminating Red Blood Cells from White Blood Cells by Using Forward Scattering from a Laser in an Automated Hematology Analyzer - A method for identifying, analyzing, and quantifying the cellular components of whole blood by means of an automated hematology analyzer and the detection of the light scattered, absorbed, and fluorescently emitted by each cell. More particularly, the aforementioned method involves identifying, analyzing, and quantifying the cellular components of whole blood by means of a light source having a wavelength ranging from about 400 nm to about 450 nm and multiple in-flow optical measurements and staining without the need for lysing red blood cells. | 2015-06-11 |
20150160190 | VAPORIZED FLUID DETECTOR CALIBRATION DEVICE - A disposable, single use calibration cartridge for calibrating vaporized fluid detection equipment, such as a breath alcohol tester. The calibration cartridge has a sealed housing having an interior volume, with a saturated working fluid present therein, the saturated working fluid present both in a vapor phase and a liquid phase. The working fluid includes the substance to be detected and a carrier fluid. | 2015-06-11 |
20150160191 | FUCOSE AS A BIOMARKER FOR GUT IMMUNITY - The present invention generally relates to the field of biomarkers. For example, the present invention relates to biomarkers that can be used to assess the likelihood of having the FUT2 secretor genotype in a subject. The invention also relates to biomarkers that can be used to assess gut health. Fucose was identified as biomarker that can be used for these purposes. | 2015-06-11 |
20150160192 | Antibody-Binding Protein-Drug Conjugate and Methods of Use - The present invention provides compositions and methods for preparing protein drug conjugate and its application to stem cell therapy and treating cancer cells. The composition is an antibody-binding-therapeutic drug conjugate that binds antibodies targeted to cancer or stem cells. The method of using the composition includes the steps of combining an antibody that targets the cancer cells or stem cells with a sample for a time sufficient to allow said antibody to bind the targeted cells present in said sample and adding the antibody-binding-drug conjugate for a time sufficient to allow binding to the antibody bound to the targeted cells. The presence of the drug reduces the number of or eliminates the targeted cancer cells or stem cells. A similar method is disclosed for selecting antibodies that may be effective antibody drug conjugates. | 2015-06-11 |
20150160193 | TUMOR CELL ISOLATION/PURIFICATION PROCESS AND METHODS FOR USE THEREOF - Methods of isolating and purifying hematologic or non-hematologic tumor cells useful in a variety of assays and procedures, including tumor drug efficacy screening such as Microculture Kinetic assays, are disclosed herein. Further, Microculture Kinetic assays and methods suitable for comparing the relative efficacy of generic versus proprietary anti-cancer drugs are also disclosed. | 2015-06-11 |
20150160194 | METHOD FOR SCREENING FOR SUBSTANCE - The object of the present invention is to provide a method for screening a substance capable of promoting induction of induced pluripotent stem cells from cells derived from an individual affected by a disease for which it is impossible to produce induced pluripotent stem cells simply by introducing reprogramming genes. The present invention provides a method for screening a substance, which comprises culturing cells derived from an individual affected by a disease for which it is impossible to produce induced pluripotent stem cells simply by introducing reprogramming genes, the cells being transfected with reprogramming genes, in the presence of test substances, and selecting a test substance capable of promoting induction of induced pluripotent stem cells from the cells. | 2015-06-11 |
20150160195 | HUMAN LIVER TUMOR CELL LINE AND METHOD OF AGENT SCREENING - An isolated human liver tumor cell line is provided and is named as ITRI-H16, and which was deposited in the Food Industry Research and Development Institute with the accession number BCRC960432 on Nov. 7, 2011. A method of an agent screening is also provided. The method includes providing the isolated human liver tumor cell line ITRI-H16 and treating an interest compound to the ITRI-H16 cell line to determine an effect of the interesting compound on the ITRI-H16 cell line. | 2015-06-11 |
20150160196 | DEVICES AND METHODS FOR DETERMINING AND/OR ISOLATING CELLS SUCH AS CIRCULATING CANCER OR FETAL CELLS - The present invention generally relates to devices and methods for determining and/or isolating cells. One aspect is generally directed to methods and devices for detecting, identifying, counting, and/or potentially sorting cells of interest in blood or other biological sample. In some embodiments, blood samples (or other biological fluids) may be treated with signaling entities, such as pH-sensitive entities, that change color or otherwise produce a signal in suitable internal environments. For example, certain cells, such as cancer or fetal cells, may have differences in intracellular pH compared to other cells, which can be detected using pH-sensitive entities. In certain embodiments, the cells may be sorted based on such signaling entities; for example, illumination of cells in a suitable machine for sorting cells (e.g., using fluorescent light) may allow determination of the cells, which may also be recovered or isolated for further manipulation in some cases. | 2015-06-11 |
20150160197 | System and Method for Analyzing Samples Labeled with 5, 10, 15, 20 Tetrakis (4-Carboxyphenyl) Porphine (TCPP) - One embodiment of the present invention provides for a method of determining if a sputum sample contains dysplastic or carcinomic cells by obtaining a sputum sample containing cells. The sputum sample is labeled with TCPP to stain cells suspected to be dysplastic or carcinomic. The labeled sputum sample is excited with an excitation wavelength of light of about 475 nm +/−30 nm and emission at about 560 nm +/−30 nm is detected from cells identified to be macrophages. An imager focuses on the plasma membrane of one or more cells suspected to be dysplastic or carcinomic and emission at about 655 nm +/−30 nm, if present, is detected for TCPP labeled cells of the sputum sample after focusing on the plasma membrane of the cells of the sputum sample. Photon flux for each pixel of a sensor is measured to obtain a value for the imaged cell. The measured value is scored to determine if a cell is cancerous or dysplastic. | 2015-06-11 |
20150160198 | DEVICES AND METHODS FOR DETERMINING AND/OR ISOLATING CELLS SUCH AS CIRCULATING CANCER OR FETAL CELLS - The present invention generally relates to devices and methods for determining and/or isolating cells. One aspect is generally directed to methods and devices for detecting, identifying, counting, and/or potentially sorting cells of interest in blood or other biological sample. In some embodiments, blood samples (or other biological fluids) may be treated with signaling entities, such as pH-sensitive entities, that change color or otherwise produce a signal in suitable internal environments. For example, certain cells, such as cancer or fetal cells, may have differences in intracellular pH compared to other cells, which can be detected using pH-sensitive entities. In certain embodiments, the cells may be sorted based on such signaling entities; for example, illumination of cells in a suitable machine for sorting cells (e.g., using fluorescent light) may allow determination of the cells, which may also be recovered or isolated for further manipulation in some cases. | 2015-06-11 |
20150160199 | DIAGNOSIS DEVICE HAVING LINEAR TRANSPORT FUNCTION AND APPLICATION THEREOF - A diagnosis device having linear transport function with capillarity action, which includes a test paper and a linear transporting means. The present invention is configured with a linear transporting means so as to achieve clear colorimetric effects without being interfered by original liquid color during diagnosis. In addition, the present invention may achieve controlled colorimetric region by confined hydrophilic area defined by hydrophobic area. Therefore, the present invention has advantages in being fast, easy to observe and cheap. A flushing bag with a linear transporting means having diagnostic capability is also herein provided, wherein the other end of the linear transporting means is connected to the flushing bag such as a tea bag, a hot spring bag or an herb medicine bag. The linear transporting means may be a cotton thread or a strip or other cellulose-based/non-cellulose-based material with capillarity transporting function. | 2015-06-11 |
20150160200 | MICROCANTILEVER SENSOR WITH BIMORPH ACTUATION AND PIEZORESISTIVE READ-OUT - There is provided a method of monitoring one or more specified reactions in a fluid medium sample using a thermal signature, comprising providing at least one micro-cantilever sensor, said micro-cantilever sensor comprising at least two materials having different coefficients of thermal expansion, and having a heater and piezo-resistive sensor integrated therein, calibrating the at least one micro-cantilever response to thermal changes to form a calibrated micro-cantilever response characteristic, starting the specified reaction in the fluid medium sample, pulsing the heater with one or more electrical pulses to induce heat generation in the micro-cantilever, sampling the output of the integrated piezo-resistive sensor to characterise a response of the micro-cantilever during the specified reaction in the fluid medium, and subtracting the calibrated micro-cantilever response characteristic from the sampled output to determine a characteristic of the one or more specified reactions in the fluid medium sample. There is also provided a method for measuring at least one thermal property of a fluid medium sample, and a fluid medium sample reaction detection apparatus. | 2015-06-11 |
20150160201 | Compositions and Methods for Detecting Unstable Arteriosclerotic Plaques - The present disclosure provides methods of detecting an unstable arteriosclerotic plaque in an individual, involving detecting in a biological sample from the individual an enzymatic cleavage product of a protein component of an arteriosclerotic plaque. The present disclosure provides methods of assessing the risk that an individual will develop an occlusive vascular event. The present disclosure further provides kits for carrying out a subject method. | 2015-06-11 |
20150160202 | Assays for Affinity Profiling of Nucleic Acid Binding Proteins - Methods, compositions and kits are disclosed for assays to determine the binding affinity of DNA-binding proteins or RNA-binding proteins for their corresponding recognition site(s). In particular, assays are disclosed for measuring binding affinities when either the binding protein, or the recognition sequence of the recognition site, or cofactor proteins, contain one or more mutations. The disclosed assays can thus be utilized to measure the effect on transcription factor binding caused by mutations within the recognition site, or mutations within the binding domain of the protein, and to provide binding affinity information that can be correlated with altered gene regulation and expression. The disclosed assays can be personalized to a specific person or organism, with the measured binding affinities based upon an individual's specific binding proteins and recognition sites. Furthermore, embodiments are capable of measuring binding affinities between multiple binding proteins and multiple recognition sites through an entirely in vitro process. | 2015-06-11 |
20150160203 | Freeze-Dried Conjugate Structure for Point-of-Care Testing (POCT) Immunochromatography, Immunoassay Kit Comprising the Same, and Method for Analysis Using the Kit - The present invention relates to a freeze-dried conjugate structure for immunochromatography, an immunoassay kit comprising the freeze-dried conjugate structure and an immunochromatographic strip, and a method for qualitatively or quantitatively analyzing an analyte in a sample using the immunoassay kit. | 2015-06-11 |
20150160204 | METHODS OF POLYPEPTIDE IDENTIFICATION, AND COMPOSITIONS THEREFOR - Methods are disclosed for identifying one or more proteins or polypeptides comprised by a sample. The methods comprise determining binding of each polypeptide with respect to each binding pool of a plurality of binding pools, wherein each binding pool comprises one or more probes which bind a structure comprised by a protein or polypeptide. In some aspects, polypeptides can be denatured and separated into individual polypeptide strands and immobilized on a solid support prior to determining binding of the binding pools. A protein, polypeptide or polypeptide strand can be identified by searching, in at least one database, for a protein or polypeptide sequence comprising binding pool targets either identical to or most similar to the binding pool targets comprised by the protein, polypeptide or polypeptide strand to be identified. Kits for identifying proteins, polypeptides and polypeptide strands are also disclosed. | 2015-06-11 |
20150160205 | Device And Method For Detecting A Target Analyte - One aspect of the present disclosure relates to a calorimeter for detecting the presence of a target analyte in a fluid sample. The calorimeter can include a support structure, a hermetically-sealed, thermally decoupled central reaction zone associated with the support structure, at least one droplet transport region, and detection electronics. The at least one droplet transport region can be associated with the support structure and configured to merge a reagent droplet with a sample droplet including the fluid sample to form a reaction droplet in the central reaction zone. The detection electronics can be in electrical and/or thermal communication with the central reaction zone and associated with the support structure. The calorimeter can be configured to detect a heat of reaction produced by a reaction event between the target analyte and a capture reagent upon formation of the reaction droplet. | 2015-06-11 |
20150160206 | MICROFLUIDIC DEVICE AND APPARATUS FOR TESTING THE SAME - Provided is a microfluidic device that is capable of rapidly performing an in vitro diagnosis and being miniaturized. The microfluidic device includes: a platform which includes a sample injection hole through which a sample may be injected; and a chamber which is formed in the platform and in which a first reagent, which includes target antigens that exist in the sample and antibodies that are specifically combined with the target antigens, and a second reagent, which includes an antigen-enzyme conjugant in which antigens that are specifically combined with the antibodies and enzymes are conjugated, are stored. | 2015-06-11 |
20150160207 | NUCLEIC ACID APTAMER-BASED DIAGNOSTIC METHODS WITH NOVEL TECHNIQUES FOR SIGNAL ENHANCEMENT - The present invention concerns methods for the detection f target molecules in a sample including several steps of signal amplification allowing the detection of a very low number of target molecules in the tested sample. The detection assay is based on the use of a universal probe which enables the signal amplification. The specific recognition of the target molecule is achieved by using a specific binding agent, preferably an aptamer. The invention further concerns kits and methods for the diagnosis of pathological conditions. | 2015-06-11 |
20150160208 | INTEGRATED DEVICE FOR ANALYTE TESTING, CONFIRMATION, AND DONOR IDENTITY VERIFICATION - The present invention provides an apparatus for fluid sample collection and analyte testing, including a sample receiving member and at least one membrane test strip, and optionally a sample retention member, fingerprint acquisition pad, and/or fluid collector. It also provides a fluid collection apparatus having an absorbent material, compression element, and closure element, and optionally a lid that allows the apparatus to be used in conjunction with a fluid container. Also provided are methods of collecting, testing, and retaining a fluid sample and verifying the identity of one or more individuals associated with the sample, such as the test subject, test administrator, and/or witnesses. | 2015-06-11 |
20150160209 | BIOMARKER FOR LYMPHOCYTIC INFUNDIBULONEUROHYPOPHYSITIS, AND USE APPLICATIONS THEREOF - The purpose of the present invention is to provide: a biomarker specific to lymphocytic infundibuloneurohypophysitis; and use applications of the biomarker. Provided are: a biomarker comprising an anti-rabphilin 3a antibody; and a test method using the biomarker. | 2015-06-11 |
20150160210 | COMPOSITIONS AND METHODS FOR ASSESSING GASTROINTESTINAL HEALTH - The present invention relates to kits designed for the collection of stool samples and methods of analyzing those samples for biological markers of maldigestion, inflammation, and imbalanced gut flora. | 2015-06-11 |
20150160211 | METHOD OF DETECTING OXA-048 CARBAPENEMASE PRODUCING BACTERIA - A method of detecting and/or specifically identifying bacteria producing OXA-048-type carbapenemase in a biological sample, includes the steps of: (a) placing the biological sample likely to contain the bacteria in contact with a reaction medium including at least one chromogenic substrate to detect an enzymatic activity, and temocillin at a concentration equal to or greater than 150 mg/L, preferably between 200 and 500 mg/L, (b) incubating the sample in the medium to allow the bacteria to grow, and (c) detecting the strains corresponding to the OXA-48 carbapenemase producing bacteria. A culture medium as implemented in step (a) is also provided. | 2015-06-11 |
20150160212 | METHOD FOR DETECTING SPECIFIC SUBSTANCE IN MILK - An immunochromatographic method for detecting a specific substance contained in milk, which comprises (1) the step of contacting the milk with a test strip having a first part retaining a labeled first antibody directed to the specific substance or the specific substance that is labeled, a second part disposed downstream from the first part, on which a second antibody directed to the specific substance is immobilized, and a third part disposed upstream from the first part or the second part and having voids enabling removal of milk fat globules contained in the milk, at the third part or a further upstream part, and (2) the step of flowing the milk up to the second part or a further downstream part to obtain a detectable signal of the label at the second part or a further downstream part. | 2015-06-11 |
20150160213 | COMPOSITIONS AND METHODS FOR ASSAYING PLATELET REACTIVITY AND TREATMENT SELECTION - Compositions and methods are provided for determining platelet reactivity where the levels of FcγRIIa on the surface of platelets is measured and if the levels of FcγRIIa are greater than a reference value, the platelets have enhanced reactivity. | 2015-06-11 |
20150160214 | Quantitation of Cellular Adhesion Dynamics Across Immobilized Receptors Under Rheological Shear Flow - The present invention includes an apparatus and methods for measuring cell or platelet adhesion comprising: a rheological shear flow surface coated with an agent that provides cell or platelet adhesion; a detector to track the transit of cells or platelets on the surface under shear flow; and a processor that calculates both a pause time and a roll time of platelets, wherein the processor determines a median and a mean pause time and a median and a mean roll time of cells or platelets and compares them to cells or platelets having at least one of: no cell adhesion dysfunction, a mild adhesion dysfunction, or a severe adhesion dysfunction, between a cell surface adhesion molecule on the cell or platelet and the agent, wherein the processor provides a real-time, quantitative measurement of a dynamic range of cell or platelet adhesion. | 2015-06-11 |
20150160215 | ISOLATING CELLS EXPRESSING SECRETED PROTEINS - A method of detecting and isolating cells that produce a secreted protein of interest (POI), for example, an antibody, comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; b) transfecting said cell simultaneously or subsequently with a second nucleic acid that encodes a POI wherein such POI is secreted; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule. | 2015-06-11 |
20150160216 | METHODS TO IDENTIFY MODULATORS OF RYR CALCIUM CHANNELS - Provided herein are methods for identifying a compound that modulates a Ryanodine receptor (Ryr). Fluorescence resonance energy transfer between an FKBP bound to an RyR and fluorescent derivatives of RyR binding partners (e.g., calmodulin) or domain-peptide biosensors is used to provide a readout dependent on the RyR functional state. The methods permit measurement of RyR present in a permeabilized cell or in a purified membrane. | 2015-06-11 |
20150160217 | GLYCAN ARRAYS FOR HIGH THROUGHPUT SCREENING OF VIRUSES - Glycan arrays that can detect and distinguish between various sub-types and strains of influenza virus are provided. Methods for using the glycan arrays with assays using nanoparticle amplification technique are disclosed. Sandwich assays using gold nanoparticles conjugated to phage particles comprising influenza virus-specific antibodies for detecting multiple serotypes using a single reaction are provided. Plurality of glycans directed to specific target HA of influenza virus comprises the array. Detector molecules comprising noble metals conjugated to (a) phage display particles expressing antibodies against hemagglutinin and (b) neuraminidase binding agents are disclosed. | 2015-06-11 |
20150160218 | Detection, Capture and Quantification of Biological Moieties from Unprocessed Bodily Fluids Using Nanoplasmonic Platform - A nanoplasmonic platform can be used for the detection and quantification of multiple HIV subtypes in whole blood with localized surface plasmon resonance. Among other things, this nanoplasmonic platform provides a viable way to detection and quantification of viral load at a point of care with significantly less cost, time, and laboratory resources than existing methods of detection. Although an example of HIV detection in whole blood is provided, the nanoplasmonic platform is adaptable to detect other pathogens and infectious agents or macromolecules. | 2015-06-11 |
20150160219 | ENZYME DETECTION DEVICE - The present invention relates to an enzyme detection device for detecting or measuring the presence in a test sample of the activity of an enzyme capable of cleaving a substrate. The invention also relates to methods for detecting enzyme activity, in particular the presence in a test sample of an enzyme capable of cleaving a substrate, and methods for determining the level or amount of such an enzyme in a test sample. | 2015-06-11 |
20150160220 | METHODS TO PREDICT PROGRESSION OF BERRET'S ESOPHAGUS TO HIGH GRADE DYSPLASIA ESOPHAGEAL ADENOCARCINOMA - In some embodiments, a method for aiding prediction of the likelihood of progression from Barrett's esophagus to high grade dysplasia or esophageal adenocarcinoma in a subject, is disclosed. The method can include (a) providing an oesophagal sample from said subject (b) determining if said sample stains abnormally with | 2015-06-11 |
20150160221 | BIOMARKERS FOR BREAST CANCER PREDICTIONS AND DIAGNOSES - The applications of CST4 gene, mRNA of CST4, cDNA of the splice variants of CST4, the amplicons of the CST4 primers, cystatin S protein coded by CST4 and epitope peptide of cystatin S in the predictions and diagnoses of human breast cancers, is disclosed in this invention. It can be used for the diagnosis and real time monitoring of breast cancers and tumor prognosis predictions. This methods disclosed are verified with large-scale clinical trials, and are of significant reliability and sensitivity. | 2015-06-11 |
20150160222 | COMPOSITIONS AND METHODS FOR PROGNOSIS AND TREATMENT OF CANCER - A method of diagnosing and/or treating a patient diagnosed with breast cancer includes the steps of: (a) identifying a patient as having a triple negative breast cancer; (b) obtaining a sample from the triple negative breast cancer patient comprising breast cancer cells; and (c) determining whether the cells in the sample express an elevated level of nuclear HSET, wherein an elevated level indicates a poorer prognosis. The method may further include the step of determining whether the cells in the sample express elevated level(s) of one or more products upregulated with HSET, elevated levels of phosphorylated histone-H3 and/or exhibit enhanced Cdk1 activity. In certain embodiments, the method further includes the step of administering one or more therapeutic agents, such as HSET inhibitors, centrosome declustering agents, PARP inhibitors, Ras/MAPK pathway inhibitors, PI3K/AKT/mTOR pathway inhibitors or a combination thereof. | 2015-06-11 |
20150160223 | METHOD OF PREDICTING NON-RESPONSE TO FIRST LINE CHEMOTHERAPY - The invention provides a method for determining a prognosis of colorectal cancer in a colorectal cancer patient, comprising classifying said patient as having a good prognosis or a poor prognosis using measurements of a plurality of gene products in a cell sample taken from said patient, said gene products being respectively products of at least 1 of the genes listed in Table 1, or respective functional equivalents thereof, wherein said good prognosis predicts a positive response to standard chemotherapy regimens, and said poor prognosis predicts non-responsiveness. Provided herein, the invention includes a gene signature to predict which patients will to benefit from standard colon cancer therapy; alternatively, patients who are classified as non-responders may be more likely to benefit from a novel agent such as a Notch inhibitor. | 2015-06-11 |
20150160224 | QUANTITATION OF BIOMARKERS FOR THE DETECTION OF PROSTATE CANCER - The present invention provides biomarkers that are useful in determining whether a subject has cancer, specifically prostate cancer. Specifically, betaine, malate, proline, N-acetylaspartate, uracil, xanthine, cysteine, alanine, and N-acetylglucosamine can be used to diagnose an individual with prostate cancer, one at risk for developing prostate cancer, and/or to determine the prognosis of a subject with prostate cancer. This invention also relates to multiplexed assays for quantitating such biomarkers. | 2015-06-11 |
20150160225 | Renal Cell Carcinoma Biomarkers and Uses Thereof - The subject disclosure concerns methods for evaluation of renal cell carcinoma (RCC). Such methods include a method of determining of a diagnosis of the individual as having or not having RCC; determination of a prognosis of a future course of RCC; determination of disease burden; or determination of recurrence of RCC in an individual who had been apparently cured of RCC. The methods each involve the detection of the value of at least one biomarker of Table 1. The biomarker value is used, in some of the methods, to determine whether the individual does or does not demonstrate evidence of disease, and in another method, to determine the degree or a score indicative of the individual's extent of disease. | 2015-06-11 |
20150160226 | METHOD, REAGENTS, AND KITS FOR DETECTING MINIMAL RESIDUAL DISEASE - The invention relates to the field of minimal residual disease (MRD) diagnostics, which is progressively more applied for the evaluation of treatment effectiveness in patients with a hematological malignancy, such as B-cell precursor acute lymphoblastic leukemia (BCP-ALL), B-cell chronic lymphocytic leukemia (B-CLL), and multiple myeloma (MM). Provided are unique reagent compositions with carefully selected and thoroughly tested combinations of antibodies, for ≧8-color flow cytometric stainings as well as for 10-color and 12-color flow cytometric stainings, which can reach sensitivities of at least 10 | 2015-06-11 |
20150160227 | ANTI-CXCR1 COMPOSITIONS AND METHODS - The present invention provides methods of treating cancer by administering an IL8-CXCR1 pathway inhibitor (e.g., an anti-CXCR1 antibody or Repertaxin) alone or in combination with an additional chemotherapeutic agent such that non-tumorigenic and tumorigenic cancer cells in a subject are killed. The present invention also provides compositions and methods for detecting the presence of and isolating solid tumor stem cells in a patient (e.g., based on the presence of CXCR1 or FBXO21). | 2015-06-11 |
20150160228 | COMPOSITIONS AND METHOD FOR DETERMINING THE EFFICACY OF AMYLOIDOSIS TREATMENTS - Embodiments described herein are directed to a composition for preparing amyloid β fibrils or oligomers in vitro, testing compounds with putative amyloid β activity, amyloid β fibrils and/or oligomers prepared using such compositions, and proteins identified as being associated with amyloid β fibrils and oligomers in the composition. | 2015-06-11 |
20150160229 | METHODS FOR DETECTION OF HEART FAILURE - Described herein are methods for diagnosing and/or treating an individual for heart failure based on the individual's level of Lp-PLA2, or the individual's level of Lp-PLA2 and GDF-15, or the individual's level of Lp-PLA2 and sST2. | 2015-06-11 |
20150160230 | METHODS OF PREDICTING AND DECREASING THE RISK OF PRE-TERM BIRTH - Provided are methods for predicting the risk of pre-term birth in a pregnant subject, for identifying a subject having an increased risk of pre-term birth, for selecting a subject for participation in a clinical study, and for decreasing the risk of pre-term birth in a subject. These methods include providing a sample from the subject and detecting the level of one or more of growth arrest-specific protein 1 (GASI), ALLI-fused gene from chromosome 4 protein (AR4)/Fragile X Mental Retardation 2 (FMR2) family member 3 (AFF3), transthyretin (TTR), ryanodine receptor 1 (RYRI), E26 transformation specific variant 6 (ETV6), claudin-10, zinc finger protein 23 (ZNF23), collagen type XXVII α1 (COL27AI), Kazrin isoform-1, keratin-associated protein 10-9 (KRTAPIO-9), Huntingtin (HTT), microtubule associated protein 9 (MAP9), coiled-coil domain-containing protein 13 (CCDC13), inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase isoform 2 (HISPPDI), immunoglobulin gamma-3 chain C (IG-HG3), cysteine- and histidine-rich protein-1 (CYHRI), and XP 002348181. | 2015-06-11 |
20150160231 | IDENTIFICATION OF METABOLITES FROM TANDEM MASS SPECTROMETRY DATA USING DATABASES OF PRECURSOR AND PRODUCT ION DATA - Techniques for identifying metabolites in a sample may utilize observed precursor and product ion data obtained by subjecting the sample to tandem mass spectrometry (MS/MS). The techniques may include first accessing a database of precursor ion data to identify one or more matching candidate metabolites in the database that match the observed precursor ion data. Each of the matching candidate metabolites may then be further validated by matching product ion data associated with the matching candidate metabolite and stored in a database of computationally generated product ion fragments with the observed product ion data comprising product ion fragments. A structure of a metabolite in the sample may be identified by selecting a candidate metabolite based on scores computed for the candidate metabolites based on the matching. Large volumes of metabolite precursor and product ion data may be analyzed in this way with improved speed and accuracy. | 2015-06-11 |
20150160232 | AUTOMATIC AMINO ACID SEQUENCING OF GLYCOPEPTIDE BY Y1 IONS - Apparatus and methods for automatic amino acid sequencing of a glycopeptide by mass spectrometry. The glycopeptide is fragmented by higher energy collision dissociation fragmentation, and sequentially fragmented by collision induced dissociation fragmentation. The glycopeptide Y1 ion is isolated, and the mass spectra of fragmented glycopeptide Y1 ions provide mass spectral peaks corresponding to the amino acid sequence of the glycopeptide. | 2015-06-11 |
20150160233 | Identification and Quantification of Intact Glycopeptides in Complex Samples - Illustrative embodiments of methods and apparatus for identifying one or more intact glycopeptides in a sample are disclosed. According to one illustrative embodiment, a method may comprise receiving data representing a plurality of mass spectra obtained from mass spectrometry of the sample, scoring data representing each of the plurality of mass spectra against data associated with target glycopeptides, and identifying one or more intact glycopeptides in the sample based at least in part on the scoring of the data representing each of the plurality of mass spectra. | 2015-06-11 |
20150160234 | Rapid and Quantitative Proteome Analysis and Related Methods - The invention provides methods for identifying polypeptides. The method can include the steps of simultaneously determining the mass of a subset of parent polypeptides from a population of polypeptides and the mass of fragments of the subset of parent polypeptides; comparing the determined masses to an annotated polypeptide index; and identifying one or more polypeptides of the annotated polypeptide index having the determined masses. The method can further include the steps of determining one or more additional characteristics associated with one or more of the parent polypeptides; comparing the determined characteristics to the annotated polypeptide index; and optionally repeating the steps one or more times, wherein a set of characteristics is determined that identifies a parent polypeptide as a single polypeptide in the annotated polypeptide index. The method can additionally include the step of quantitating the amount of the identified polypeptide in a sample containing the polypeptide. | 2015-06-11 |
20150160235 | ANTI-MIF IMMUNOHISTOCHEMISTRY - The present invention pertains to the specific detection of MIF, in particular oxMIF, in tissues. A detection method is provided which uses immunohistochemistry and wherein specific anfi-oxMIF antibodies are used. | 2015-06-11 |
20150160236 | Methods For Determining Anti-TNF Therapeutic Response - The present invention relates to methods for identifying patients that will respond to treatment with anti-TNF-therapy, i.e., anti-TNF responder patients. In particular, the present invention relates to determining response to an inhibitor of tumor necrosis factor (TNF) in a patient with a chronic inflammatory disease by determining the activity of type I interferon in the patient. The invention further relates to quantification of type I interferon as a measure of predicting responsiveness to anti-TNF therapy in patients with a chronic inflammatory disease such as rheumatoid arthritis (RA), psoriatic arthritis, ankylosing spondylitis, juvenile chronic arthritis, lupus, Crohn's disease, as well as for cardiovascular disease. | 2015-06-11 |
20150160237 | COMPOSITIONS OF CARDIOMYOCYTE SUBPOPULATIONS - The present invention provides the use of the antigens CD49e and/or CD49f as selection markers for enrichment, isolation, detection and/or analysis of atrial and ventricular cardiomyocytes and a method for enrichment, isolation, detection and/or analysis of these cells from a sample comprising cardiomyocytes. In addition substantially pure compositions of these cardiomyocyte subpopulations are provided. | 2015-06-11 |
20150160238 | Means and Methods for Diagnosing and Monitoring Heart Failure in a Subject - The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject and a method for monitoring progression or regression of heart failure in a subject. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices. | 2015-06-11 |
20150160239 | MARKER PEPTIDE FOR DETERMINING RISK OF DEVELOPING METABOLIC SYNDROME, AND USE THEREOF - It is an object of the present invention to provide a marker substance capable of accurately determining a risk of developing metabolic syndrome in vivo. That is, the present invention provides the followings: a marker peptide for determining the risk of developing the metabolic syndrome; an antibody or an aptamer bound to the marker peptide for determining the risk of developing the metabolic syndrome; a microarray in which the antibody or the aptamer bound to the marker peptide for determining the risk of developing the metabolic syndrome has been immobilized on a carrier; a method for determining the risk of developing the metabolic syndrome, comprising measuring an amount or the presence or absence of the marker peptide for determining the risk of developing the metabolic syndrome in a biological sample collected from a subject; and a kit for determining the risk of developing the metabolic syndrome, comprising the antibody or the aptamer or comprising the microarray. | 2015-06-11 |
20150160240 | Host Biomarkers for Dengue Fever (DF) and Methods Thereof - The present invention provides methods of determining whether a subject has a Dengue virus infection that is likely to develop into a life-threatening Dengue disease and methods of selecting a treatment regimen for a subject in need thereof who has been infected with a Dengue virus. The invention further provides a prognostic kit for distinguishing a subject who is likely to develop a mild Dengue disease from a subject who is likely to develop a life-threatening Dengue disease. The methods and kits of the invention can be used to differentiate DHF from DF and severe and non-severe forms of Dengue with high sensitivity and specificity. | 2015-06-11 |
20150160241 | GAMMA-AMINOBUTYRIC ACID A RECEPTOR SUBUNIT BIOMARKERS - The invention provides physical diagnostic tests for schizophrenia, bipolar disorder, major depression, and autism. | 2015-06-11 |
20150160242 | POLYMER MATRIX WITH TARGET BINDING SITE FOR CREATININE AND DERIVATIVES THEREOF, ITS PREPARATION AND USES - This invention provides a polymer matrix with target binding site and methods for preparing the same. This invention further provides uses of the polymer matrix in the separation or extraction of creatinine from complex mixtures, and in methods, kits and devices for detecting creatinine content in samples. | 2015-06-11 |
20150160243 | Method for Determining Volume and Hemoglobin Content of Individual Red Blood Cells - Provided herein is a method for determining the volume or hemoglobin content of an individual red blood cell in a sample containing a population of red blood cells. The method may be performed on a hematology analyzer. Also provided are a hematology analyzer for performing the method and a computer-readable medium containing programming for performing the method. | 2015-06-11 |
20150160244 | METHOD AND SYSTEM FOR ESTIMATING THE QUANTITY OF AN ANALYTE CONTAINED IN A LIQUID - This method for estimating the quantity of an analyte contained in a liquid includes the following steps:
| 2015-06-11 |
20150160245 | PPM QUANTIFICATION OF IODATE USING PAPER DEVICE - A highly sensitive method that utilizes a Paper Analytical Device (PAD) which measures part per million (ppm) levels of iodate iodometric titration is provided. The PAD quantifies concentrations of 0.6-15 parts per million (ppm) of iodine. The PAD has at least 12 reaction zones that contain dried reagents thereon and at least one electronically readable information zone. Salt and water are mixed and drops are placed onto 12 reaction zones that contain the loaded dry reagents. The PAD is shaken and the reaction zones turn blue if a preset iodate concentration has been exceeded. Test results are analyzed by comparing the PAD or an image of the PAD with standards, either by eye or with image analysis software to measure the color intensities which are compared to a calibration curve to quantify the iodate levels. The image analysis quantifies iodine with an average absolute accuracy and precision of 0.9 ppm over a range of 0.6-15 ppm. | 2015-06-11 |
20150160246 | DEVICES AND METHODS FOR DETERMINING AND/OR ISOLATING CELLS SUCH AS CIRCULATING CANCER OR FETAL CELLS - Some embodiments of the present invention generally relate to devices and methods for determining and/or isolating cells. For example, one aspect is generally directed to methods and devices for detecting, identifying, counting, and/or potentially sorting cells of interest in blood or other biological sample. In some embodiments, blood samples (or other biological fluids) may be treated with signaling entities, such as pH-sensitive entities, that change color or otherwise produce a signal in suitable internal environments. For example, certain cells, such as cancer or fetal cells, may have differences in intracellular pH compared to other cells, which can be detected using pH-sensitive entities. In certain embodiments, the cells may be sorted based on such signaling entities; for example, illumination of cells in a suitable machine for sorting cells (e.g., using fluorescent light) may allow determination of the cells, which may also be recovered or isolated for further manipulation in some cases. | 2015-06-11 |
20150160247 | Sensitive Efficacy and Specificity Biomarkers for Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibition - The present invention inter alia provides a method, and uses thereof, to measure drug efficacy and specificity of treatment with an inhibitor of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) by detecting the concentrations of lipids and/or lipid-lipid concentration ratios of a biological sample and comparing it to a control. The invention is applicable, inter alia, to determining whether a PCSK9 inhibiting drug is functioning efficiently in lowering serum low-density lipoprotein (LDL) concentration and whether a PCSK9 inhibiting drug displays any adverse side-effects, such as liver toxicity. Provided are lipid markers that are more specific and sensitive in detecting drug efficacy and possible adverse drug-induced side-effects than the currently utilized clinical markers. Also provided is an antibody towards said lipids, and the use thereof for predicting and diagnosing of PCSK9 inhibiting drug-induced adverse reactions. The invention additionally relates to kits comprising lipids and/or an antibody thereto, for the determination of PCSK9 inhibiting drug efficacy and drug-induced adverse reactions. | 2015-06-11 |
20150160248 | Apparatus and Method for Spectroscopic Analysis of Vinification Liquids Using Coded Sample Containers - An apparatus for spectroscopic analysis of vinificition liquids features a sample holder for a sample container of vinification liquid, a light source for directing a beam of light into the sample supported by the sample holder, a spectrometer arranged for receiving and measuring the beam of light after interaction thereof with the sample in order to perform a spectroscopic scan of the sample and generate measured spectral data thereon, and a scanning device positioned for scanning a machine readable code on the sample container. A computing device in communication with the spectrometer and the scanning device applies a classification to the measured spectral data of the sample according to a classification code read from the sample container. The classification code is used to determine what parameters should be calculated from the spectral data for the particular sample in question. | 2015-06-11 |
20150160249 | TUBE RACK TRANSFER DEVICE AND DIAGNOSTIC INSTRUMENT - A tube rack transfer device for transferring racks is presented. A first rail extends in a first horizontal direction and a second rail extends in a second horizontal direction orthogonal to the first direction. The second rail moves along the first rail and comprising a transfer head movable along the second rail. The transfer head comprises a control pin to be coupled with one of: an input pusher, translatable in the second direction, for transferring a rack from a carrier to a sampling area of an analyzer; an output pusher for transferring a rack from the sampling area to a carrier; a rack for transferring the rack between different carriers and/or between different positions of the same carrier. An in-vitro diagnostic instrument comprises an analyzer for carrying out tests on biological samples, a sample unit for inputting/outputting racks, a sampling area for withdrawing samples from tubes, and a transfer device. | 2015-06-11 |
20150160250 | DEVICE FOR GRIPPING VESSELS - A device for gripping vessels is presented. The device comprises a mount, a support having a longitudinal axis coupled to the mount so to be rotatable relative to the mount around the longitudinal axis, a rotating mechanism for rotating the support, a gripper coupled to the support so to be translatable relative to the support along the longitudinal axis. The gripper has jaws for gripping a vessel, a translating mechanism for translating the gripper, at least one actuator for driving the translating mechanism and/or rotating mechanism and at least two reference elements fixed to the mount in at least two different stop positions. The jaws are passively biasable towards each other for holding a vessel in positions other than the at least two stop positions. The jaws are actively biasable away from each other by pushing the gripper against a reference element in one of the stop positions. | 2015-06-11 |