24th week of 2020 patent applcation highlights part 33 |
Patent application number | Title | Published |
20200181665 | FUCOSYLTRANSFERASES AND THEIR USE IN PRODUCING FUCOSYLATED OLIGOSACCHARIDES - Disclosed are novel fucosyltransferases being capable of transferring a fucose residue from a donor substrate to a lactotetraose, methods for producing fucosylated oligosaccharides utilizing said fucosyltransferases, and the use of the thus produced fucosylated oligosaccharides for manufacturing nutritional compositions. | 2020-06-11 |
20200181666 | NUCLEIC ACID MUTAGENESIS METHODS - The present disclosure relates to the manipulation of nucleic acids, and more particularly to systems and methods for nucleic acid mutagenesis. | 2020-06-11 |
20200181667 | METHODS FOR SEAMLESS NUCLEIC ACID ASSEMBLY - Provided herein are methods, systems, and compositions for seamless nucleic acid assembly. Such methods, systems, and compositions for seamless nucleic acid assembly include those for in vitro recombination cloning, single-stranded hierarchal DNA assembly, or overlap extension PCR without primer removal. | 2020-06-11 |
20200181668 | METHOD FOR PREPARING TROXERUTIN ESTER USING WHOLE-CELL CATALYSIS - A method for preparing troxerutin ester using whole-cell catalysis belongs to the fields of biological catalysis and pharmaceutical chemistry. The method specifically includes the following steps: evenly mixing troxerutin and a mixed organic solvent containing pyridine, then adding an acyl donor and a whole-cell catalyst, and performing a reaction under oscillation at a reaction temperature of 25° C. to 55° C.; and after the reaction is finished, separating and purifying a product by column chromatography or thin-layer chromatography, so as to obtain the troxerutin ester. The invention has the advantages of mild reaction conditions, environmental friendliness, simple process, fewer side reactions and high selectivity. | 2020-06-11 |
20200181669 | METHOD FOR THE PRODUCTION OF A GLYCOSYLATED IMMUNOGLOBULIN - Herein is reported a method for the production of an immunoglobulin comprising the following steps: a) providing a eukaryotic cell comprising a nucleic acid encoding the immunoglobulin, b) cultivating the eukaryotic cell in a cultivation medium wherein the amount of glucose available in the cultivation medium per time unit is kept constant and limited to less than 80% of the amount that could maximally be utilized by the cells in the cultivation medium per time unit, and c) recovering the immunoglobulin from the culture. | 2020-06-11 |
20200181670 | Improved In Vitro Transcription/Translation (TXTL) System and Use Thereof - Provided herein, in one aspect, is a composition for in vitro transcription and translation, comprising: a treated cell lysate derived from one or more host cells such as bacteria, archaea, plant or animal; a plurality of supplements for gene transcription and translation; an energy recycling system for providing and recycling adenosine triphosphate (ATP); and one or more exogenous additives. Methods for making and using the same are also provided. | 2020-06-11 |
20200181671 | Method for Increasing Content of Mogroside V in Siraitia Grosvenorii Suspended Cells - The present invention relates to a method for increasing the content of mogroside V in | 2020-06-11 |
20200181672 | PROCESSES USING AMINO ACID DEHYDROGENASES AND KETOREDUCTASE-BASED COFACTOR REGENERATING SYSTEM - The present disclosure relates to the use of an amino acid dehydrogenase in combination with a cofactor regenerating system comprising a ketoreductase. In particular embodiments, the process can be used to prepare L-tert-leucine using a leucine dehydrogenase. | 2020-06-11 |
20200181673 | SENSORS, METHODS AND KITS FOR DETECTING NADPH BASED ON RESONANCE ENERGY TRANSFER - The invention relates to the detection of the cofactor reduced nicotinamide adenine dinucleotide phosphate (NADPH). Provided is a sensor molecule for the resonance energy transfer (RET)-based detection of NADPH, the sensor comprising a segment A connected via a linker to a segment B, wherein each of segment A and segment B comprises a member of a RET pair comprising a donor moiety and an acceptor moiety, further characterized in that (i) segment A comprises a binding protein (BP) for NADPH, the BP being dihydrofolate reductase (DHFR; EC 1.5.1.3) or a functional homolog, fragment, derivative or variant thereof, showing the desired NADPH binding properties, and wherein the BP comprises a heterologous protein domain inserted at or replacing at least part of the region corresponding to positions (20) to (27) of | 2020-06-11 |
20200181674 | METHOD OF DIAGNOSING A DYSBIOSIS - The present disclosure relates to methods of diagnosing a dysbiosis in a subject, methods of determining a suitable treatment, and methods of treating a dysbiosis. In some aspects, the present disclosure relates to diagnosing or determining a subtype of irritable bowel syndrome (IBS). | 2020-06-11 |
20200181675 | METHOD FOR SCREENING ANTIMICROBIAL AGENT - A method for screening an antimicrobial agent which is capable of controlling microorganisms causing offensive odor in an air-conditioning system and a method for removing offensive odor in an air-conditioning system are provided. The method for screening an antimicrobial agent and the method for removing offensive odor in an air-conditioning system may be used for various purposes of industrial application. For example, they may be used to develop a novel antimicrobial agent capable of inhibiting the growth of the microorganisms or to develop an air freshener for removing offensive odor by elucidating the chemical properties of the metabolites of the microorganisms. In addition, they may be used to fundamentally remove the cause of offensive odor by providing an air-conditioning system with an environment where the microorganisms may not live. | 2020-06-11 |
20200181676 | PHOSPHATIDYLINOSITOL QUANTIFICATION METHOD AND QUANTIFICATION KIT - Disclosed is a method for quantifying phosphatidylinositol in a sample, comprising the following step: (1) treating the sample with phospholipase D and inositol dehydrogenase; and a kit for quantifying phosphatidylinositol, containing phospholipase D and inositol dehydrogenase. | 2020-06-11 |
20200181677 | SCREENING SYSTEM AND METHODS FOR IDENTIFYING ENZYME SUBSTRATES AND MODULATORS OF ENZYME ACTIVITY - Materials and methods for identifying modulators of protein function (e.g., enzyme activity), including modulators that target particular substrates for enzymes, are provided herein. | 2020-06-11 |
20200181678 | Cell-Based Reporter Assay for Live Virus Vaccines - The present invention relates to a cell-based reporter assay for determining viral potency comprising A) transfecting cells maintained in media with a promoter-reporter construct and generating reporter enzyme within the cells; B) infecting cells with a live virus or live virus vaccine wherein reporter enzyme is released into media; and C) measuring reporter enzyme intensity in media. | 2020-06-11 |
20200181679 | WASH MONITOR AND METHOD OF USE - The present disclosure provides a monitoring device comprising a test composition, a test element comprising a test portion to which the test composition is releasably adhered, a detection reagent, and a container comprising a first end with an opening and a second end opposite the first end. The test composition comprises a predetermined quantity of tracer analyte. The container is configured to receive the test portion and configured to be operationally coupled to an analytical instrument. The tracer analyte and the detection reagent each are capable of participating in one or more chemical reaction that results in the formation of a detectable product. A method of using the monitoring device to assess the efficacy of a washing process is also provided. | 2020-06-11 |
20200181680 | METHODS AND SYSTEMS FOR DETECTING ENTITIES IN A BIOLOGICAL SAMPLE - Apparatus and methods for use with a blood sample are described. The blood sample is stained with Hoechst stain and Acridine Orange stain. A plurality of images of the blood sample are acquired. An object is identified as being a white blood cell candidate. A first stained area, which is stained by the Hoechst stain and which is disposed within the white blood cell candidate, is identified. A second stained area, which is stained by the Acridine Orange stain and which is disposed within the white blood cell candidate, is identified. A white blood cell is detected by determining that structural features of the stained areas satisfy predetermined criteria associated with a white blood cell. Other applications are also described. | 2020-06-11 |
20200181681 | MULTIPLEXED OPTIMIZED MISMATCH AMPLIFICATION (MOMA)-REAL TIME PCR FOR ASSESSING CANCER - This invention relates to methods and compositions for assessing an amount of cancer-specific nucleic acids in a sample, such as from a subject. The methods and compositions provided herein can be used to determine risk of a condition, such as cancer, in a subject. | 2020-06-11 |
20200181682 | PCR VESSEL, PCR VESSEL CONTAINING REAGENT, AND REAGENT CASSETTE - A PCR vessel ( | 2020-06-11 |
20200181683 | IN VITRO ISOLATION AND ENRICHMENT OF NUCLEIC ACIDS USING SITE-SPECIFIC NUCLEASES - The present invention relates to a method for the isolation of a target nucleic acid region. In particular, said method comprises the steps of contacting a population of nucleic acid molecules with at least one Type II Cas protein-gRNA complex, wherein said gRNA comprises a guide segment that is complementary to the sequence comprised in the target region of at least one nucleic acid molecule, thereby forming a Type II Cas protein-gRNA-nucleic acid complex, contacting the population of nucleic acid molecules with at least one enzyme having exonuclease activity, and isolating the target nucleic acid region from the Type II Cas protein-gRNA-nucleic acid complex. | 2020-06-11 |
20200181684 | DEVICE AND METHOD FOR IMMOBILISING BIOMOLECULES USING MAGNETIC PARTICLES - A device for the reversible immobilization of biomolecules by magnetic particles includes a container. The container is configured to be filled with a liquid containing biomolecules and a magnet. The magnet is arranged on the container in such a way that magnetic particles arranged in the container and to which the biomolecules are capable of being immobilized, are configured to be fixed in the container. An inhomogeneous magnetic field id configured to act on the magnetic particles disposed in the container and is capable of being generated by the arrangement of the magnet, so that the magnetic particles are arranged in a structured manner by the influence of the inhomogeneous magnetic field. | 2020-06-11 |
20200181685 | NON-THERMAL CYCLING FOR POLYMERASE CHAIN REACTION - Techniques, systems, and devices are disclosed for non-thermal cycling of polymerase chain reaction (PCR). In one aspect, a method for cycling PCR includes receiving an electrolytic fluid including ions, primers, polymerase enzymes, nucleotides, and a double-stranded nucleic acid in a fluid chamber having a first electrode and a second electrode, applying an electric field across the first and the second electrodes to generate a first pH level of the electrolytic fluid to denature the double-stranded nucleic acid to at least partial single strands, and applying a second electric field across the first and second electrodes to produce a second pH level of the electrolytic fluid, in which the second pH level enables binding of a polymerase enzyme and a primer with a corresponding segment of the single strands. | 2020-06-11 |
20200181686 | METHODS AND COMPOSITIONS FOR CLUSTER GENERATION BY BRIDGE AMPLIFICATION - The present disclosure is concerned with compositions and methods for reducing the steps used in the generation of monoclonal clusters by combining the enzymes used for linearization and removal of unused surface primers. | 2020-06-11 |
20200181687 | METHODS AND COMPOSITIONS FOR PREPARING NUCLEIC ACID LIBRARIES - Embodiments provided herein relate to methods and compositions for preparing nucleic acid libraries. Some embodiments include preparing libraries from nucleic acids obtained from degraded samples, such as ancient samples and fixed samples. | 2020-06-11 |
20200181688 | GROWTH-INDEPENDENT DETECTION OF CELLS - Disclosed herein are various methods, systems, and compositions for the growth independent detection of cells such as microorganisms including bacteria. While existing cellular detection methodologies benefit from cell growth, the methods, systems, and compositions disclosed herein demonstrate embodiments that are independent of cell growth while still allowing for cell-based detection. | 2020-06-11 |
20200181689 | METHOD FOR IDENTIFYING HELICOBACTER PYLORI INFECTION BY DETECTION OF THE UREC AND CAGA GENES IN STOOL SAMPLES - The invention relates to a method for identifying | 2020-06-11 |
20200181690 | PRIMER AND PROBE FOR DETECTION OF MYCOBACTERIUM AVIUM AND METHOD FOR DETECTION OF MYCOBACTERIUM AVIUM BY USING THE PRIMER OR PROBE - The object of the present invention is to provide a novel primer for use in the detection of | 2020-06-11 |
20200181691 | COMPOSITIONS AND METHODS FOR DETECTION OF MYCOPLASMA GENITALIUM - Methods for the rapid detection of the presence or absence of | 2020-06-11 |
20200181692 | METHODS AND SYSTEMS FOR NUCLEIC ACID AMPLIFICATION - The disclosure provides methods and systems for nucleic acid amplification including isothermal nucleic acid amplification. | 2020-06-11 |
20200181693 | DESIGN OF DIGITAL PCR FOR NON-INVASIVE PRENATAL TESTING - Techniques are provided for determining settings of a dPCR experiment for the detection of a chromosomal aneuploidy in a plasma sample from a female pregnant with a fetus. Data about the sample, the dPCR process, and a desired accuracy can be used to determine the settings. Such settings can include a minimal input number of control chromosome molecules for the dPCR experiment, a minimal number of control chromosome molecules for a pre-amplification procedure, and a number of PCR cycles in the pre-amplification procedure. These settings can be used to satisfy the accuracy specified by the accuracy data. Thus, the dPCR experiment can be designed to achieve the desired accuracy while reducing cost, e.g., by not using more of a sample than needed and not performing more pre-amplification than needed or performing more manipulations than needed. | 2020-06-11 |
20200181694 | HIGH THROUGHPUT DETECTION OF MOLECULAR MARKERS BASED ON AFLP AND HIGH THROUGH-PUT SEQUENCING - The present invention relates to a high throughput method for the identification and detection of molecular markers wherein restriction fragments are generated and suitable adaptors comprising (sample-specific) identifiers are ligated. The adapter-ligated restriction fragments may be selectively amplified with adaptor compatible primers carrying selective nucleotides at their 3′ end. The amplified adapter-ligated restriction fragments are, at least partly, sequenced using high throughput sequencing methods and the sequence parts of the restriction fragments together with the sample-specific identifiers serve as molecular marker. | 2020-06-11 |
20200181695 | GRAPHENE FET DEVICES, SYSTEMS, AND METHODS OF USING THE SAME FOR SEQUENCING NUCLEIC ACIDS - Provided herein are devices, systems, and methods of employing the same for the performance of bioinformatics analysis. The apparatuses and methods of the disclosure are directed in part to large scale graphene FET sensors, arrays, and integrated circuits employing the same for analyte measurements. The present GFET sensors, arrays, and integrated circuits may be fabricated using conventional CMOS processing techniques based on improved GFET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense GFET sensor based arrays. Improved fabrication techniques employing graphene as a reaction layer provide for rapid data acquisition from small sensors to large and dense arrays of sensors. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes, including DNA hybridization and/or sequencing reactions. Accordingly, GFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis within a gated reaction chamber of the GFET based sensor. | 2020-06-11 |
20200181696 | SEQUENCE ASSEMBLY - The invention relates to assembly of sequence reads. The invention provides a method for identifying a mutation in a nucleic acid involving sequencing nucleic acid to generate a plurality of sequence reads. Reads are assembled to form a contig, which is aligned to a reference. Individual reads are aligned to the contig. Mutations are identified based on the alignments to the reference and to the contig. | 2020-06-11 |
20200181697 | METHODS FOR NON-INVASIVE PRENATAL PLOIDY CALLING - The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR. | 2020-06-11 |
20200181698 | METHOD FOR HIGH-THROUGHPUT AFLP-BASED POLYMORPHISM DETECTION - The invention relates to a method for the high throughput discovery, detection and genotyping of one or more genetic markers in one or more samples, comprising the steps of restriction endonuclease digest of DNA, adaptor-ligation, optional pre-amplification, selective amplification, pooling of the amplified products, sequencing the libraries with sufficient redundancy, clustering followed by identification of the genetic markers within the library and/or between libraries and determination of (co-)dominant genotypes of the genetic markers. | 2020-06-11 |
20200181699 | NUCLEIC ACID SYNTHESIS TECHNIQUES - A method for synthesizing a nucleic acid includes synthesizing one or more nucleic acid fragments on a substrate. The synthesized one or more nucleic acid fragments may be amplified on the substrate. The method also includes sequencing the synthesized or amplified one or more nucleic acid fragments on the substrate. The sequencing may provide feedback to designs of the one or more nucleic acid fragments. The method further includes harvesting the synthesized or amplified one or more nucleic acid fragments based on sequencing. The synthesized or amplified one or more nucleic acid fragments may be assembled to generate a target nucleic acid. | 2020-06-11 |
20200181700 | Genome Fractioning - Disclosed herein are compositions and methods related to the elimination of molecules of a selected sequence from a nucleic acid sample or from an sequence dataset resulting from the sequencing of a sample, for example to exclude such molecules from downstream analysis or sequencing, or to exclude such sequences from a downstream data set. | 2020-06-11 |
20200181701 | COMPOSITIONS AND METHODS FOR DETECTING ALLOGENEIC MATTER IN A SUBJECT - The present disclosure provides a panel of nucleic acid molecule primers specific for HLA-specific alleles and other genetic polymorphisms, which are useful for quantitatively amplifying these markers to detect, diagnose, and monitor individuals who have or are at risk of certain disease conditions, such as autoimmune disease, proliferative disease, infectious disease, allograft rejection, or pregnancy-related pathologies. | 2020-06-11 |
20200181702 | COMPOSITIONS AND METHODS FOR DETECTING ALLOGENEIC MATTER IN A SUBJECT - The present disclosure provides a panel of nucleic acid molecule primers specific for HLA-specific alleles and other genetic polymorphisms, which are useful for quantitatively amplifying these markers to detect, diagnose, and monitor individuals who have or are at risk of certain disease conditions, such as autoimmune disease, proliferative disease, infectious disease, allograft rejection, or pregnancy-related pathologies. | 2020-06-11 |
20200181703 | EPIGENOME-WIDE ASSOCIATION STUDY IDENTIFIES CARDIAC DEVELOPMENTAL GENE PATTERNING AND A NOVEL CLASS OF BIOMARKERS FOR HEART FAILURE - The present invention relates to a method of determining markers for a disease from a patient, wherein information from epigenomics and/or the transcriptome from peripheral blood and a diseased tissue or information from epigenomics and the transcriptome from peripheral blood or a diseased tissue is used for obtaining the markers, as well as a method of determining a risk for a disease in a patient using the markers obtained thereby. | 2020-06-11 |
20200181704 | METHOD FOR DETERMINING ATTENTION DEFICIT HYPERACTIVITY - A method can determine Attention-Deficit Hyperactivity Disorder (ADHD) and/or evaluate the prognosis and/or determine the effectiveness of a therapy against ADHD. The method is based on measuring the methylation levels of CpG dinucleotides and/or CpG islands in a genomic region of the SLC6A3 gene (solute carrier family 6 member 3), preferably in the 5′ UTR. | 2020-06-11 |
20200181705 | TWO MOLECULAR MARKERS, KITS AND APPLICATIONS FOR GLAUCOMA DIAGNOSIS - The present invention discloses two molecular markers, kits and applications for glaucoma diagnosis. Compared with people in a control group, the expressions of lncRNAs: T267384 are all up-regulated in aqueous humors and serums of patients with glaucoma, and the expression of lncRNAs: ENST00000564363 is up-regulated in aqueous humors of patients with glaucoma. It indicates that T267384 and ENST00000564363 are highly expressed lncRNAs in glaucoma and are biomarkers that contribute to the diagnosis of glaucoma. The present invention provides a strong molecular biology basis for the diagnosis of glaucoma, and has far-reaching clinical significance and generalization performance. | 2020-06-11 |
20200181706 | BIOMARKERS FOR ASSESSING THE RESPONSE STATUS FOR TREATMENT OF INFLAMMATORY CONDITION OR DISEASE AFFECTING THE DIGESTIVE TRACT SUCH AS INFLAMMATORY BOWEL DISEASE IN HUMAN PATIENTS - The invention relates to the identification of biomarkers of the response status of a patient for a treatment with anti-TNFalpha agents, for treatment with anti-α4β7 agents or with both anti-TNFalpha agent and anti-α4β7 agents and to their use in assessing such status, in particular for assessing nonresponsive status for a treatment with anti-TNFalpha agents or respectively with anti-α4β7 agent in human patients suffering from inflammatory condition or disease, in particular Inflammatory Bowel Disease (IBD), in particular Ulcerative Colitis or Crohn's disease. The invention describes a method of in vitro assessing whether a treatment with anti-TNFalpha agent or with anti-α4β7 agent may be useful in a human patient suffering from inflammatory condition or disease, in particular when said condition or disease is a chronic and/or relapsing one, particularly a gastrointestinal, more particularly intestinal, inflammatory condition or disease which is eligible for treatment with anti-TNFalpha agent or respectively with anti-α4β7 agent. In a specific embodiment the method is suitable to assess whether such patient would be non-responsive to treatment with such anti-TNFalpha agent or respectively with anti-α4β7 agent and comprising determining a molecular signature in a biological sample previously obtained from said human patient. | 2020-06-11 |
20200181707 | METHOD AND SOFTWARE TO DETERMINE PROBABILITY OF SLEEP/WAKE STATES AND QUALITY OF SLEEP AND WAKEFULNESS FROM AN ELECTROENCEPHALOGRAM - Methods and apparatus are provided to format a probability index that reflects where an electroencephalogram (EEG) pattern lies within the spectrum of wakefulness to deep sleep, which employs a computer/microprocessor that performs frequency domain analysis of one or more discrete sections of the EEG to determine the EEG power or amplitude at specified frequencies, optionally calculates the total power or amplitude over specified frequency ranges, assigns a rank to the power or amplitude at each frequency, or frequency range, assigns a code that reflects the ranking of the different frequencies or frequency ranges, and determines an index that reflects where the EEG pattern within the section(s) lies within the spectrum of wakefulness to deep sleep by use of a reference source, such as a look-up table or other suitable decoding instrument. The reference source is obtained by calculating the probability of different codes occurring in epochs scored as awake or asleep in reference files scored by one or more expert technologists or by an automatic scoring software. | 2020-06-11 |
20200181708 | MICRO-RNAS THAT MODULATE LYMPHANGIOGENESIS AND INFLAMMATORY PATHWAYS IN LYMPHATIC VESSEL CELLS - The subject invention pertains to methods of identifying miRNAs that are differentially expressed in a lymphatic vessel cell under a proinflammatory stimulus. The invention also pertains to profiles of miRNAs that are differentially expressed in a lymphatic vessel cell under a proinflammatory stimulus and their use as biomarkers for diagnosis of inflammation-mediated diseases. The current invention also provides therapeutic agents for the treatment of inflammation-mediated lymphatic diseases wherein the therapeutic agents are capable of modulating the activity of the miRNAs differentially expressed in a lymphatic vessel cell under a proinflammatory stimulus. | 2020-06-11 |
20200181709 | METHODS OF DETECTION AND TREATMENT OF UROTHELIAL CANCER - The invention provides methods for detecting a cellular proliferative disorder (e.g., urothelial cancer) in a subject by assessing the methylation status of the CCND2, CCNA1 or CALCA promoter in a nucleic acid sample. The methods of the invention are useful for diagnostic, prognostic as well therapeutic regimen predictions. | 2020-06-11 |
20200181710 | METHODS, COMPOSITIONS, KITS AND DEVICES FOR RAPID ANALYSIS OF BIOLOGICAL MARKERS - Provided herein are kits, devices and methods for rapid analysis of biological samples. In particular, kits, devices and methods described herein can be applied to rapid nucleic acid analysis of solid tissue samples. | 2020-06-11 |
20200181711 | COMPOSITIONS AND METHODS FOR MONITORING, DIAGNOSIS, PROGNOSIS, DETECTION, AND TREATMENT OF CANCER - The present invention relates to the field of cancer and inflammation, and in particular methods of monitoring, diagnosis, prognosis, detecting, treating and preventing cancer and inflammation conditions. The use of composition comprises method of monitoring, diagnosis, prognosis, and detecting cancer and inflammation with EN2 and/or SATB2 expression and/or activity. The pharmaceutical composition will further comprise agents that inhibit EN2 and/or SATB2 expression or activity. | 2020-06-11 |
20200181712 | A METHOD FOR PREDICTING A BREAST CANCER PATIENT'S RESPONSE TO ANTHRACYCLINE TREATMENT - The present invention relates to a method for predicting a breast cancer patient's response to anthracycline treatment. | 2020-06-11 |
20200181713 | METHOD FOR PROGNOSING AND DIAGNOSING TUMORS - The present invention is in the field of tumor prognosis and relates to a method of providing a prognosis to an individual suffering from a tumor. Further, the present invention relates to a method of diagnosing a hepatocellular carcinoma (HCC) in an individual, a method of diagnosing a hepatitis C virus (HCV) infectionin an individual, a method of diagnosing a hepatitis B virus (HBV) infection in an individual, and a method of diagnosing a viral induced hepatocellular carcinoma in an individual. Furthermore, the present invention relates to a method of differentiating between at least two conditions in an individual, wherein the at least two conditions are selected from the group consisting of a hepatocellular carcinoma (HCC), hepatitis C virus (HCV) infection, hepatitis B virus (HBV) infection, and a viral induced hepatocellular carcinoma (HCC). In addition, the present invention relates to a method for diagnosing a lymphoma in an individual. More-over, the present invention relates to a kit for conducting the above mentioned methods. | 2020-06-11 |
20200181714 | NOX2 as a Biomarker of Radiotherapy Efficiency in Cancer Patients - Although tumor-associated macrophages have been extensively studied in the control of response to radiotherapy, the molecular mechanisms involved in the ionizing radiation-mediated activation of macrophages remain elusive. Here the present inventors show that ionizing radiation induces the expression of interferon-regulatory factor 5 (IRF5) promoting thus macrophage activation toward a pro-inflammatory phenotype. They reveal that the activation of the Ataxia telangiectasia mutated (ATM) kinase is required for ionizing radiation-elicited macrophage activation, but also for macrophage reprogramming after treatments with γ-interferon, lipopolysaccharide or chemotherapeutic agent (such as cis-platin), underscoring the fact that the kinase ATM plays a central role during macrophage phenotypic switching toward a proinflammatory phenotype. They further demonstrate that NADPH oxidase 2 (NOX2)-dependent ROS production is upstream to ATM activation and is essential during this process. They also report that hypoxic conditions and the inhibition of any component of this signaling pathway (NOX2, ROS and ATM) impairs pro-inflammatory activation of macrophages and predicts a poor tumor response to preoperative radiotherapy in locally advanced rectal cancer. Altogether, these results identify a novel signaling pathway involved in macrophage activation that may enhance effectiveness of radiotherapy through the re-programming of tumor infiltrating macrophages. | 2020-06-11 |
20200181715 | PRKC FUSIONS - The invention provides PRKC gene fusions, PRKC fusion proteins, and fragments of those genes and polypeptides. The invention further provides methods of diagnosing and treating diseases or disorders associated with PRKC fusions, such as conditions mediated by aberrant PRKC expression or activity, or overexpression of PRKC. | 2020-06-11 |
20200181716 | COMPOSITE EPIGENETIC BIOMARKERS FOR ACCURATE SCREENING, DIAGNOSIS AND PROGNOSIS OF COLORECTAL CANCER - The present disclosure concerns particular biomarkers for screening, diagnosing and/or prognosticating colorectal cancer, in particular in an accurate manner. The methods and compositions concern analysis of methylation patterns of one or more of 176 methylatable genomic DNA regions identified as described herein. In particular embodiments there are methods of detecting methylatable regions in genomic sequences. | 2020-06-11 |
20200181717 | ISOFORMS OF GATA6 AND NKX2-1 AS MARKERS FOR DIAGNOSIS AND THERAPY OF CANCER AND AS TARGETS FOR ANTI-CANCER THERAPY - The present invention relates to a method of assessing whether a subject suffers from cancer or is prone to suffering from cancer, in particular lung cancer, comprising the measurement of the amounts of specific isoforms of GATA6 and/or NKX2-1 in a sample of said subject. Furthermore, the present invention relates to a composition for use in medicine comprising (an) inhibitor(s) of specific isoforms of GATA6 and/or NKX2-1. Additionally, the present invention relates to a kit for use in a method of assessing whether a subject suffers from cancer or is prone to suffering from cancer, in particular lung cancer. | 2020-06-11 |
20200181718 | METHODS FOR DETECTING GENE DYSREGULATION BY INTRAGENIC DIFFERENTIAL EXPRESSION - Described herein are methods, compositions and kits directed to the detection of gene dysregulations such as those arising from gene fusions and/or chromosomal abnormalities, e.g., translocations, insertions, inversions and deletions. Samples containing dysregulated gene(s) of interest may show independent expression patterns for the 5′ and 3′ regions of the gene. The methods, compositions and kits are useful for detecting mutations that cause the differential expression of a 5′ portion of a target gene relative to the 3′ region of the target gene. | 2020-06-11 |
20200181719 | CHROMOSOMAL ASSESSMENT TO DIFFERENTIATE HISTIOCYTIC MALIGNANCY FROM LYMPHOMA AND HEMANGIOSARCOMA IN DOGS - This invention relates generally to the discovery of an improved method to differentiate histiocytic malignancy from lymphoma or hemangiosarcoma in dogs. | 2020-06-11 |
20200181720 | CRISPR EFFECTOR SYSTEM BASED DIAGNOSTICS FOR VIRUS DETECTION - Provided herein is a nucleic acid detection system comprising: a CRISPR system comprising an effector protein and one or more guide RNAs designed to bind to corresponding target molecules; an RNA-based masking construct; and optionally, nucleic acid amplification reagents to amplify target RNA molecules in a sample. In another aspect, the embodiments provide a polypeptide detection system comprising: a CRISPR system comprising an effector protein and one or more guide RNAs designed to bind a trigger RNA, an RNA-based masking construct; and one or more detection aptamers comprising a masked RNA polymerase promoter binding site or a masked primer binding site. In some embodiments, the system may be used to detect viruses in samples. | 2020-06-11 |
20200181721 | PROCESS FOR SUGAR PRODUCTION - The application relates to methods and systems for producing a sugar product. The method includes: receiving a first input in a control system representative of a pre-treatment sugar composition characteristic; receiving a second input in the control system representative of a post-treatment sugar product target specification; using the control system to determine at least one operating parameter for a centrifuge and operating the centrifuge in accordance with the at least one determined operating parameter, wherein the at least one determined operating parameter is determined from at least: the first input, the second input, and a correlation relating at least the first input and the second input to the at least one operating parameter; and treating the pre-treatment sugar composition in the centrifuge to produce a post-treatment sugar product with a characteristic that is at or nearer to the target specification than the characteristic of the pre-treatment sugar composition. | 2020-06-11 |
20200181722 | A COMBINED FABRICATING METHOD FOR GRADIENT NANOSTRUCTURE IN SURFACE LAYER OF METAL WORKPIECE - The present invention relates to a combined fabricating method for gradient nanostructure in the surface layer of a metal workpiece, i.e., first, a plastic deformation layer in great depth is induced by laser shock peening, then the surface of the metal workpiece is nanocrystallized by surface mechanical attrition treatment, and finally gradient nanostructure is obtained in the surface layer of the metal workpiece with desirable layer thickness and optimized micro-structure distribution. With the method provided in the present invention, gradient nanostructure with desirable layer thickness and optimized micro-structural distribution can be obtained in the surface layer, and the surface roughness of the metal workpiece can be significantly improved at the same time; the technique breaches the “reversed relationship” between strength and plasticity, ensures coexistence of good plasticity and high strength, and greatly improves the overall mechanical properties of the metal workpiece, including fatigue life and wear resistance, etc. The method provided in the present invention can induce gradient nanostructure in the surface layer of a metal workpiece, including aluminum alloy, titanium alloy, magnesium alloy, stainless steel, and nickel-based superalloy, etc., and is applicable to many fields such as strengthening and reparation of key and important parts in aeronautic and astronautic industry, automobile manufacturing and ship building industries, and chemical industry, etc. | 2020-06-11 |
20200181723 | METHOD FOR THERMAL PROCESSING BULLETS - A method for thermal processing bullets to yield a refined grain structure, the method includes obtaining one or more bullets, disposing the one or more bullets within a chamber having a temperature gradient between ambient temperature and cryogenic temperature, the chamber having a plurality of temperature zones, moving the one or more bullets between the plurality of temperature zones of the chamber at a predetermined rate, and returning the one or more bullets to the ambient temperature. | 2020-06-11 |
20200181724 | HOT-WORK MOLD STEEL FOR DIE CASTING AND METHOD OF MANUFACTURING THE SAME - A hot-work mold steel includes 0.37 to 0.46 wt % of carbon (C), 0.25 to 0.5 wt % of silicon (Si), 0.36 to 0.56 wt % of manganese (Mn), 2.0 to 5.0 wt % of chromium (Cr), 1.4 to 2.6 wt % of molybdenum (Mo), 0.4 to 0.8 wt % of vanadium (V), 0.0007 to 0.004 wt % of boron (B), 0.002 to 0.022 wt % of aluminum (Al), 0.001 to 0.09 wt % of titanium (Ti) and the remainder of iron (Fe) and inevitable impurities. The hot-work mold steel exhibits superior thermal conductivity, hardenability, durability, and nitriding characteristics, and increased resistance to heat check and melt-out. A die-casting mold made of the steel has improved thermal o conductivity regardless of mold size and a prolonged life cycle and can improve the surface quality in manufactured parts. | 2020-06-11 |
20200181725 | GRAIN-ORIENTED ELECTRICAL STEEL SHEET - A grain-oriented electrical steel sheet includes a steel layer and an insulation coating arranged in directly contact with the steel layer thereon. The steel layer includes, as a chemical composition, by mass %, 2.9 to 4.0% of Si, 2.0 to 4.0% of Mn, 0 to 0.20% of Sn, and 0 to 0.20% of Sb. In the steel layer, a silicon content and a manganese content expressed in mass % satisfy 1.2%≤Si−0.5×Mn≤2.0%, and a tin content and an antimony content expressed in mass % satisfy 0.005%≤Sn+Sb≤0.20%. | 2020-06-11 |
20200181726 | METHOD OF MANUFACTURING CAM PIECE FOR CONTINUOUSLY VARIABLE VALVE DURATION AND CAM PIECE MANUFACTURED THEREFROM - A method of manufacturing a cam piece for a continuously variable valve duration and a cam piece manufactured therefrom, and more particularly, to material and heat treatment conditions of a cam piece, may include manufacturing a cam piece by casting; heating the cam piece; maintaining a heating temperature; and salt-bathing the cam piece, in which the cam piece includes 3.2 to 4.2 wt % of carbon (C), 2.2 to 3.4 wt % of silicon (Si), and the balance iron (Fe), and may have a carbon equivalent value of 4.4 to 4.6. | 2020-06-11 |
20200181727 | NON-ORIENTED ELECTRICAL STEEL HAVING EXCELLENT MAGNETIC PROPERTIES - A non-oriented electrical steel having excellent magnetic properties, the chemical elements thereof in percentage by mass being: Si: 0.2-1.5%, Mn: 0.01-0.30%, Al: 0.001-0.009%, O: 0.005-0.02%, C≤0.005%, S≤0.005%, N≤0.005%, and Ti≤0.002%, the remainder being Fe and other unavoidable impurities, and Al/Si≤0.006 and Mn/Si≤0.2. The method for producing comprises the following sequence of steps: (1) smelting; (2) hot rolling: the slab heating temperature being 850° C. to 1250° C., and the final rolling temperature being 800-1050° C.; (3) acid pickling; (4) cold rolling; (5) annealing: the annealing plate temperature being controlled between 620° C.-900° C.; and (6) coating. | 2020-06-11 |
20200181728 | STEEL SHEET FOR CARBURIZING, AND METHOD FOR MANUFACTURING STEEL SHEET FOR CARBURIZING - [Object] To provide a steel sheet for carburizing that demonstrates improved ductility, and a method for manufacturing the same. | 2020-06-11 |
20200181729 | ZINC-COATED STEEL SHEET WITH HIGH RESISTANCE SPOT WELDABILITY - A method for producing a zinc or zinc-alloy coated steel sheet with a tensile strength higher than 900 MPa, for the fabrication of resistance spot welds containing in average not more than two Liquid Metal Embrittlement cracks per weld having a depth of 100 μm or more, with steps of providing a cold-rolled steel sheet, heating cold-rolled steel sheet up to a temperature T1 between 550° C. and Ac1+50° C. in a furnace zone with an atmosphere (A1) containing from 2 to 15% hydrogen by volume, so that the iron is not oxidized, then adding in the furnace atmosphere, water steam or oxygen with an injection flow rate Q higher than (0.07%/h×α), α being equal to 1 if said element is water steam or equal to 0.52 if said element is oxygen, at a temperature T≥T1, so to obtain an atmosphere (A2) with a dew point DP2 between −15° C. and the temperature Te of the iron/iron oxide equilibrium dew point, then heating the sheet from temperature T | 2020-06-11 |
20200181730 | HOMOGENIZATION PROCESS FOR COILED TUBING - A homogenization process for coiled tubing is provided. After being preheated in a sectional manner and quenched and tempered, laser-welded low-carbon alloy steel coiled tubing is spray cooled, and then is tempered to obtain homogeneous silvery coiled tubing. Microstructural uniformity of the slivery coiled tubing after the treatment is greatly improved in a welding seam region, a heat sensing region, and a tube wall, situations in which an outer surface of the coiled tubing is burnt and oxidized in the homogenization process are reduced, and a service life of the coiled tubing is prolonged. Moreover, homogeneous coiled tubing with different yield strengths and tensile strengths can be obtained by changing a temperature of the tempering, so that production costs are reduced. | 2020-06-11 |
20200181731 | Process for Leaching Metal Sulfides with Reagents Having Thiocarbonyl Functional Groups - This application pertains to methods of recovering metals from metal sulfides that involve contacting the metal sulfide with an acidic sulfate solution containing ferric sulfate and a reagent that has a thiocarbonyl functional group, wherein the concentration of reagent in the acidic sulfate solution is sufficient to increase the rate of metal ion extraction relative to an acidic sulfate solution that does not contain the reagent, to produce a pregnant solution containing the metal ions. | 2020-06-11 |
20200181732 | Process for Leaching Metal Sulfides with Reagents Having Thiocarbonyl Functional Groups - This application pertains to methods of recovering metals from metal sulfides that involve contacting the metal sulfide with an acidic sulfate solution containing ferric sulfate and a reagent that has a thiocarbonyl functional group, wherein the concentration of reagent in the acidic sulfate solution is sufficient to increase the rate of metal ion extraction relative to an acidic sulfate solution that does not contain the reagent, to produce a pregnant solution containing the metal ions. | 2020-06-11 |
20200181733 | Process for Leaching Metal Sulfides with Reagents Having Thiocarbonyl Functional Groups - This application pertains to methods of recovering metals from metal sulfides that involve contacting the metal sulfide with an acidic sulfate solution containing ferric sulfate and a reagent that has a thiocarbonyl functional group, wherein the concentration of reagent in the acidic sulfate solution is sufficient to increase the rate of metal ion extraction relative to an acidic sulfate solution that does not contain the reagent, to produce a pregnant solution containing the metal ions. | 2020-06-11 |
20200181734 | Process for Leaching Metal Sulfides with Reagents Having Thiocarbonyl Functional Groups - This application pertains to methods of recovering metals from metal sulfides that involve contacting the metal sulfide with an acidic sulfate solution containing ferric sulfate and a reagent that has a thiocarbonyl functional group, wherein the concentration of reagent in the acidic sulfate solution is sufficient to increase the rate of metal ion extraction relative to an acidic sulfate solution that does not contain the reagent, to produce a pregnant solution containing the metal ions. | 2020-06-11 |
20200181735 | Process for Leaching Metal Sulfides with Reagents Having Thiocarbonyl Functional Groups - This application pertains to methods of recovering metals from metal sulfides that involve contacting the metal sulfide with an acidic sulfate solution containing ferric sulfate and a reagent that has a thiocarbonyl functional group, wherein the concentration of reagent in the acidic sulfate solution is sufficient to increase the rate of metal ion extraction relative to an acidic sulfate solution that does not contain the reagent, to produce a pregnant solution containing the metal ions. | 2020-06-11 |
20200181736 | Process for Leaching Metal Sulfides with Reagents Having Thiocarbonyl Functional Groups - This application pertains to methods of recovering metals from metal sulfides that involve contacting the metal sulfide with an acidic sulfate solution containing ferric sulfate and a reagent that has a thiocarbonyl functional group, wherein the concentration of reagent in the acidic sulfate solution is sufficient to increase the rate of metal ion extraction relative to an acidic sulfate solution that does not contain the reagent, to produce a pregnant solution containing the metal ions. | 2020-06-11 |
20200181737 | Process for Leaching Metal Sulfides with Reagents Having Thiocarbonyl Functional Groups - This application pertains to methods of recovering metals from metal sulfides that involve contacting the metal sulfide with an acidic sulfate solution containing ferric sulfate and a reagent that has a thiocarbonyl functional group, wherein the concentration of reagent in the acidic sulfate solution is sufficient to increase the rate of metal ion extraction relative to an acidic sulfate solution that does not contain the reagent, to produce a pregnant solution containing the metal ions. | 2020-06-11 |
20200181738 | COPPER ALLOY CONTAINING TIN, METHOD FOR PRODUCING SAME, AND USE OF SAME - The invention relates to a high-strength as-cast copper alloy containing tin, with excellent hot-workability and cold-workability properties, high resistance to abrasive wear, adhesive wear and fretting wear, and improved corrosion resistance and stress relaxation resistance, consisting (in wt. %) of: 4.0 to 23.0% Sn, 0.05 to 2.0% Si, 0.005 to 0.6 B, 0.001 to 0.08% P, optionally up to a maximum of 2.0% Zn, optionally up to a maximum of 0.6% Fe, optionally up to a maximum of 0.5% Mg, optionally up to a maximum of 0.25% Pb, with the remainder being copper and inevitable impurities, characterised in that the ratio of Si/B of the element content of the elements silicon and boron lies between 0.3 and 10. The invention also relates to a casting variant and a further-processed variant of the tin-containing copper alloy, a production method, and the use of the alloy. | 2020-06-11 |
20200181739 | HIGH-STRENGTH FREE-CUTTING COPPER ALLOY AND METHOD FOR PRODUCING HIGH-STRENGTH FREE-CUTTING COPPER ALLOY - This high-strength free-cutting copper alloy comprises 75.4-78.0% Cu, 3.05-3.55% Si, 0.05-0.13% P and 0.005-0.070% Pb, with the remainder comprising Zn and inevitable impurities, wherein the amount of Sn existing as inevitable impurities is at most 0.05%, the amount of Al is at most 0.05%, and the total amount of Sn and Al is at most 0.06%. The composition satisfies the following relations: 78.0≤f1=Cu+0.8×Si+P+Pb≤80.8; and 60.2≤f2=Cu−4.7×Si−P+0.5×Pb≤61.5. The area percentage (%) of respective constituent phases satisfies the following relations: 29≤κ≤60; 0≤γ≤0.3; β=0; 0≤μ≤1.0; 98.6≤f3=α+κ; 99.7≤f4=α+κ+γ+μ; 0≤f5=γ+μ≤1.2; and 30≤f6=κ+6×γ | 2020-06-11 |
20200181740 | ALUMINIUM ALLOY FOR PISTON AND PISTON FOR ENGINE OF VEHICLE - An aluminum alloy for a piston may include aluminum (Al) as a base, magnesium (Mg) and zinc (Zn); and wherein the magnesium content is 10-20 wt % with reference to the total weight. In the aluminum alloy, the zinc content is 2.0-6.4 wt % with reference to the total weight. The aluminum alloy further includes copper (Cu) of 1.5-3.5 wt % with reference to the total weight. In the aluminum alloy, T-AlCuMgZn phase is generated. | 2020-06-11 |
20200181741 | Aluminum Alloy Wire, Aluminum Alloy Strand Wire, Covered Electrical Wire, and Terminal-Equipped Electrical Wire - An aluminum alloy wire composed of an aluminum alloy is provided. The aluminum alloy contains at least 0.03 mass % and at most 1.5 mass % of Mg, at least 0.02 mass % and at most 2.0 mass % of Si, and a remainder composed of Al and an inevitable impurity, a mass ratio Mg/Si being not lower than 0.5 and not higher than 3.5. In a transverse section of the aluminum alloy wire, a rectangular surface-layer crystallization measurement region having a short side of 50 μm long and a long side of 75 μm long is taken from a surface-layer region extending by up to 50 μm in a direction of depth from a surface of the aluminum alloy wire, and an average area of crystallized materials present in the surface-layer crystallization measurement region is not smaller than 0.05 μm | 2020-06-11 |
20200181742 | MAGNESIUM DIE CASTING ALLOY - Disclosed are a magnesium die casting alloy, and an alloy composition for improving thermal conductivity and electrical conductivity. A magnesium die casting alloy includes an amount of about 0.5 to 2.0 wt % of aluminum (Al) and the balance magnesium (Mg), based on the total weight of the magnesium die casting alloy. Accordingly, an alloy, which has high thermal conductivity and electrical conductivity as compared to a conventional AZ91D magnesium alloy, is obtained. | 2020-06-11 |
20200181743 | NICKEL TITANIUM ALLOYS, METHODS OF MANUFACTURE THEREOF AND ARTICLE COMPRISING THE SAME - Disclosed herein is a shape memory alloy comprising 48 to 50 atomic percent nickel, 15 to 30 atomic percent hafnium, 1 to 5 atomic percent aluminum; with the remainder being titanium. Disclosed herein too is a method of manufacturing a shape memory alloy comprising mixing together to form an alloy nickel, hafnium, aluminum and titanium in amounts of 48 to 50 atomic percent nickel, 15 to 30 atomic percent hafnium, 1 to 5 atomic percent aluminum; with the remainder being titanium; solution treating the alloy at a temperature of 700 to 1300° C. for 50 to 200 hours; and aging the alloy at a temperature of 400 to 800° C. for a time period of 50 to 200 hours to form a shape memory alloy. | 2020-06-11 |
20200181744 | STEEL SHEET FOR CARBURIZING, AND METHOD FOR MANUFACTURING STEEL SHEET FOR CARBURIZING - [Object] To provide a steel sheet for carburizing that demonstrates improved extreme deformability prior to carburizing, and a method for manufacturing the same. | 2020-06-11 |
20200181745 | FERRITIC ALLOY - A ferritic alloy comprising the following elements in weight % C 0.01 to 0.1; N: 0.001 to 0.1; 0: <0.2; Cr 4 to 15; Al 2 to 6; Si 0.5 to 3; Mn: ≤0.4; Mo+W≤4; Y≤1.0; Sc, Ce, La and/or Yb≤0.2; Zr≤0.40; RE≤3.0; balance Fe and normal occurring impurities and also fulfilling the following equation has to be fulfilled: 0.014≤(Al+0.5SQ (Cr+10Si+0.1)≤0.022. | 2020-06-11 |
20200181746 | ALUMINUM ALLOYS WITH HIGH STRENGTH AND COSMETIC APPEAL - The disclosure provides an aluminum alloy including having varying ranges of alloying elements. In various aspects, the alloy has a wt % ratio of Zn to Mg ranging from 4:1 to 7:1. The disclosure further includes methods for producing an aluminum alloy and articles comprising the aluminum alloy. | 2020-06-11 |
20200181747 | CONTINUOUS WIRE DRAWING APPARATUS AND METHOD - A continuous wire drawing apparatus includes: a wire releasing scrollbar and a wire collecting scrollbar being respectively a wire releasing end and a wire collecting end of a metal wire material; a wire drawing force control unit and a back force control unit providing a drawing force and a back force to the wire collecting end and the wire releasing end respectively; a heating unit disposed between the wire releasing end and the wire collecting end, and adapted to heat the metal wire material continuously at a heating temperature in a heating area, whereby the metal wire material is deformed by a strength difference between the drawing force and the back force; and a cooling unit disposed between the heating unit and the wire collecting end, and adapted to cool the metal wire material continuously at a cooling temperature in a cooling area. | 2020-06-11 |
20200181748 | FREE-CUTTING COPPER ALLOY AND METHOD FOR PRODUCING FREE-CUTTING COPPER ALLOY - This free-cutting copper alloy comprises 76.0-78.7% Cu, 3.1-3.6% Si, 0.40-0.85% Sn, 0.05-0.14% P, and at least 0.005% to less than 0.020% Pb, with the remainder comprising Zn and inevitable impurities. The composition satisfies the following relations: 75.0≤f1=Cu+0.8×Si−7.5×Sn+0.5×Pb≤78.2; 60.0≤f2=Cu−4.8×Si—0.8×Sn−P+0.5×Pb≤61.5; and 0.09≤f3=P/Sn≤0.30. The area percentage (%) of respective constituent phases satisfies the following relations: 30≤κ≤65; 0≤γ≤2.0; 0≤β≤0.3; 0≤μ≤2.0; 96.5≤f4=α+κ; 99.4≤f5=α+κ+γ+μ; 0≤f6=γ+μ≤3.0; and 35≤f7=1.05×κ+6×γ | 2020-06-11 |
20200181749 | TITANIUM ALLOYS HAVING IMPROVED CORROSION RESISTANCE, STRENGTH, DUCTILITY, AND TOUGHNESS - Titanium alloys with an improved and unexpected combination of corrosion resistance, strength, ductility and toughness are provided. The titanium alloys contain molybdenum, nickel, zirconium, iron, and oxygen as alloying agents. Also the titanium alloys may be subjected to thermal treatments. The titanium alloys can include molybdenum between 3.0 to 4.5 wt. %, nickel between 0.1 to 1.0 wt. %, zirconium between 0.1 to 1.5 wt. %, iron between 0.05 to 0.3 wt. %, oxygen between 0.05 to 0.25 wt. %, and a balance of titanium and unavoidable impurities. The titanium alloys can have a yield strength between 550 to 750 MPa, a tensile strength between 700 to 900 MPa, an elongation to failure between 25 to 35%, a reduction in area between 55 to 70%, and a corrosion rate between 0.5 to 2.5 mils per year when exposed to 1 wt. % boiling hydrochloric acid per the ASTM G-31 test method. | 2020-06-11 |
20200181750 | METHOD FOR PRODUCING A HIGH STRENGTH STEEL SHEET HAVING HIGH DUCTILITY, FORMABILITY AND WELDABILITY, AND OBTAINED STEEL SHEET - A method for producing a high-strength steel sheet having high ductility, formability and weldability includes providing a cold-rolled sheet, with a composition containing: 0.15% ≤C≤0.23%, 1.4% ≤Mn≤2.6%, 0.6% ≤Si≤1.3%, with C+Si/10≤0.30%, 0.4% ≤Al≤1.0%, with Al≥6(C+Mn/10)−2.5%, 0.010% ≤Nb≤0.035%, 0.1% ≤Mo≤0.5%, annealing the sheet at 860° C.-900° C. to obtain a structure consisting of at least 90% austenite and at least 2% intercritical ferrite, quenching to a temperature between Ms-10° C. and Ms-60° C. at a rate Vc higher than 30° C./s, heating to a temperature PT between 410° C. and 470° C. for 60 s to 130 s, hot-dip coating the sheet, and cooling to room temperature. The microstructure includes 45% to 68% of martensite, consisting of 85% to 95% partitioned martensite having a C content of at most 0.45%, and fresh martensite; 10% to 15% retained austenite; 2% to 10% intercritical ferrite; 20% to 30% lower bainite. | 2020-06-11 |
20200181751 | Zn-Al-Mg-BASED PLATED STEEL SHEET - This Zn—Al—Mg-based plated steel sheet has a steel sheet, an alloy layer which is formed on a surface of the steel sheet and contains Fe and Si, and a plated layer which is formed on a surface of the alloy layer opposite to the steel sheet, in which an average composition of the plated layer and the alloy layer includes, in mass %, Al: 45.0 to 65.0%, Si: 0.50 to 5.00%, Mg: 1.00 to 10.00%, and a balance of Zn, Fe, and impurities, the plated layer contains 0.1 to 20.0% of a Mg-Si phase in terms of volume fraction, in a case where a 1 μm range from a surface of the plated layer in a thickness direction of the plated layer is defined as a surface layer area of the plated layer, an average equivalent circle diameter of the Mg-Si phase in the surface layer area in a direction in which the plated layer is overserved in a plane view is 0.1 to 15.0 μm, and an integrated value of a Si content from the surface of the plated layer to thickness center of the plated layer is 0.55 times or more of an integrated value of the Si content from the surface of the plated layer to an interface. | 2020-06-11 |
20200181752 | HIGH TEMPERATURE IMAGING MEDIA FOR DIGITAL IMAGE CORRELATION - A thermal barrier coating is provided. The thermal barrier coating is configured to remain adherent to the substrate under high strains, thus allowing the use of non-contacting strain measurement systems, such as digital image correlation. The thermal barrier coating may include a first layer of a partially metallic material configured to adhere to a metallic substrate, and a second layer of a partially ceramic material configured to adhere to the first layer. A successful configuration has a top layer thickness that is approximately two-thirds of the first layer thickness. | 2020-06-11 |
20200181753 | IMPLANTABLE GRAFT AND METHODS OF MAKING SAME - The present invention relates to an implantable endoluminal graft. The implantable endoluminal graft is comprised of a microporous thin-film metal covering having a plurality of openings and a structural support element underlying and physically attached to the microporous thin-film metal covering, the microporous thin-film metal covering having shape memory properties. | 2020-06-11 |
20200181754 | A MASK AND A MASK DEVICE USING THE SAME - The present invention provides a mask and a mask device using the same. The advantage of the present invention is that, buffer zones at both ends of an existing mask are set as an effective evaporation zone, which can be used to make a Mini display panel with pixels of a low density, so it not only can be used as one deformation buffer zone, but also can be used as one effective opening zone applied to a display panel with pixels of a low density, thereby effectively improving the utilization efficiency of the mask. | 2020-06-11 |
20200181755 | VAPOR DEPOSITION MASK, VAPOR DEPOSITION APPARATUS, VAPOR DEPOSITION MASK PRODUCTION METHOD, AND ELECTROLUMINESCENT DISPLAY APPARATUS PRODUCTION METHOD - A vapor deposition mask includes, in a layered manner: a metal mask including at least one metal mask opening; and a resin mask including a plurality of resin mask openings. The resin mask openings are arranged at least one in a Y-axial direction. The resin mask openings exposed from the metal mask opening and aligned in the Y-axial direction in the respective positions in an X-axial direction have such total opening lengths in the Y-axial direction as to increase from the center in the X-axial direction toward both end portions in the X-axial direction. | 2020-06-11 |
20200181756 | METAL CUTTING TOOL WITH MULTI-LAYER COATING - A metal cutting tool includes a main body made of cemented carbide, cermet, ceramic, steel or high-speed steel, and a multi-layer wear protection coating. The wear protection coating includes a lower layer having an overall composition of Ti | 2020-06-11 |
20200181757 | COATED CUTTING TOOL AND A PROCESS FOR ITS MANUFACTURE - A coated cutting tool and a process for manufacturing a coated cutting tool consisting of a substrate and a single-layer or multi-layer hard material coating. The substrate is selected from cemented carbide, cermet, ceramics, cubic boron nitride, polycrystalline diamond or high-speed steel. The hard coating includes at least one layer of Al | 2020-06-11 |
20200181758 | APPARATUS AND METHODS OF SUBLIMATION FOR REPEATABLE UNIFORM OR PATTERNED DEPOSITION OF MATRIX CRYSTALS ON SOLID SUBSTRATES - This disclosure relates to apparatus and methods for sublimation and deposition of chemicals. In particular aspects, this disclosure relates to apparatus and methods for patterned sublimation and deposition of chemicals for use in matrix assisted laser desorption ionization imaging mass spectrometry (MALDI IMS). In specific aspects, the apparatus comprises a vacuum chamber and a template comprising a planar surface containing the chemical to be sublimed, where the template is located within the vacuum chamber. | 2020-06-11 |
20200181759 | VAPOR DEPOSITION CRUCIBLE - A vapor deposition crucible is provided and includes a crucible body and a heat conduction device disposed in the crucible body. The crucible body includes a crucible base and a sidewall connected to the crucible base. The heat conduction device is connected securely to the sidewall, and the heat conduction device is honeycomb-shaped and includes a plurality of channels arranged abreast, extending along an axial direction of the crucible body and configured to accommodate a vapor deposition material. In comparison to the prior art, heat of the vapor deposition material in the channels has a short lateral conduction distance, and the heat received by the vapor deposition material is from the heat conduction device with an excellent heat conductivity such that the vapor deposition material can receive heat sufficiently in the channels, which increases stability of vapor deposition velocity and further improves quality of the OLED display panel. | 2020-06-11 |
20200181760 | SYSTEMS AND METHODS FOR OPTIMAL SOURCE MATERIAL DEPOSITION ALONG HOLE EDGES - A method for depositing a coating of a source material onto a panel is disclosed. The method includes providing a cathodic arc, the cathodic arc including a target surface, the target surface disposed along a target deposition axis and able to emit the source material as a generally cloud of source material vapor and a generally conical stream of liquid particles of the source material. The method further includes positioning the panel relative to the target surface based on a deposition angle, the deposition angle being between the target surface and an outer limit of the generally conical stream of liquid particles o the source material. The method may further include emitting the source material from the target surface as the generally conical cloud of source material vapor and coating the edge with the cloud of source material vapor to provide an edge coating. | 2020-06-11 |
20200181761 | SPUTTERING TARGET AND MANUFACTURING METHOD THEREOF - A sputtering target includes: a base configured to transfer heat in a basal plane direction; and a first heat sink disposed on a sidewall of the base, the first heat sink configured to transfer heat along a direction that is different from the basal plane direction. | 2020-06-11 |
20200181762 | ALUMINUM ALLOY SPUTTERING TARGET - Disclosed is an aluminum alloy sputtering target containing 0.01 atomic % to 0.04 atomic % in total of at least one element selected from the group consisting of Ni, Cr, Fe, Co and Cu, and 0.01 atomic % to 0.06 atomic % in total of at least one element selected from rare earth elements other than La, the balance being Al and inevitable impurities. | 2020-06-11 |
20200181763 | BROADBAND OPTICAL MONITORING - A method of in situ monitoring a thin film deposition process on a substrate, the method including a) defining a desired spectrum, the desired spectrum being a transmission or a reflection spectrum; b1) illuminating the substrate by means of a light source emitting light within the desired spectrum, b2) receiving light reflected from the substrate or transmitted through the substrate, b3) determining a transmission or a reflection spectrum out of the received light; c) defining a spectrum or a combination of spectra in dependency of the spectrum determined in step b3) to be a current spectrum; d) determining a weight spectrum as a function of the current spectrum; e) calculating a real number as a function of the current spectrum, of the desired spectrum and of the weight spectrum; f) exploiting the real number as indication for a deviation of the current spectrum from the desired spectrum. | 2020-06-11 |
20200181764 | HIGHLY ADHESIVE CVD GROWN BORON DOPED DIAMOND GRADED LAYER ON WC-CO - Improved thin film coatings, cutting tool materials and processes for cutting tool applications are disclosed. A boron-doped graded diamond thin film for forming a highly adhesive surface coating on a cemented carbide (WC—Co) cutting tool material is provided. The thin film is fabricated in a HFCVD reactor. It is made of a bottom layer of BMCD in contact with a surface layer of the cemented carbide, a top layer made of NCD and a transition layer with a decreasing concentration gradient of boron obtained by changing the reaction conditions through ramp up option in hot filament CVD reactor. The top layer has a low friction coefficient. The bottom layer in the coating substrate interface has better interfacial adhesion through cobalt and boron reactivity and decreased cobalt diffusivity in the diamond. The transition layer has minimized lattice mismatch and sharp stress concentration between the top and bottom layers. | 2020-06-11 |