26th week of 2014 patent applcation highlights part 58 |
Patent application number | Title | Published |
20140179508 | DIELECTRIC COMPOSITION - Disclosed herein is a dielectric composition including: a dielectric ceramic represented by the following equation: X | 2014-06-26 |
20140179509 | POROUS GLASS CERAMIC COMPOSITION AND METHOD FOR MANUFACTURING THE SAME - The invention provides a porous glass ceramic composition manufactured using conventional raw materials and one or more waste materials, wherein the waste materials are capable of producing glass forming oxides, glass modifying oxides and pore forming oxides. The waste materials are selected from a group that includes cullet, pozzolanic waste and fly ash. The invention also provides a method for manufacturing the porous glass ceramic composition. | 2014-06-26 |
20140179510 | GLASS WITH IMPROVED TOTAL PITCH STABILITY - Described herein are alkali-free, boroalumino silicate glasses exhibiting desirable physical and chemical properties for use as substrates in flat panel display devices, such as, active matrix liquid crystal displays (AMLCDs) and active matrix organic light emitting diode displays (AMOLEDs). In accordance with certain of its aspects, the glasses possess excellent compaction and stress relaxation properties. | 2014-06-26 |
20140179511 | CERAMIC PARTICLE MIXTURE, AND METHOD FOR MANUFACTURING CERAMIC PARTS FROM SUCH A MIXTURE - The invention relates to a ceramic particle mixture containing, as components, a predominant portion by weight of frittable particles made of a ceramic material and particles of at least one additive, at least one additive being a dispersed absorbent solid inorganic material which has, for a laser beam emitted at a predetermined wavelength, a specific absorptivity that is greater than the absorptivity of the other components of the ceramic mixture, and which drastically breaks down when gas is emitted in the presence of the laser beam, said additive being present in proportions of less than 5% of the dry weight. The invention also relates to ceramic parts produced from such a mixture. | 2014-06-26 |
20140179512 | PHOTOCATALYST FOR THE PRODUCTION OF HYDROGEN - A method and composition for making photocatalytic capped colloidal nanocrystals include semiconductor nanocrystals and inorganic capping agents as photocatalysts. The photocatalytic capped colloidal nanocrystals may be deposited on a substrate and treated to form a photoactive material that may be used in a plurality of photocatalytic energy conversion applications such as water splitting. By combining different semiconductor materials for photocatalytic capped colloidal nanocrystals employed and by changing the semiconductor nanocrystals shapes and sizes, band gaps can be tuned to expand the range of wavelengths of sunlight usable by the photoactive material. The disclosed photocatalytic capped colloidal nanocrystals within the photoactive material may also exhibit a higher efficiency of solar energy conversion process derived from a higher surface area of the semiconductor nanocrystals within photocatalytic capped colloidal nanocrystals available for the absorption of sunlight and enhancement of charge carrier dynamics. | 2014-06-26 |
20140179513 | PRODUCTION OF A CATALYTICALLY ACTIVE, METALLIZED REACTIVE FOAM MATERIAL AND USE THEREOF - The invention relates to a catalytic material which is used as an optofluidic reactor, and also a method for production thereof. In this case, first a reticulated plastic foam can be fabricated which then is coated with at least one first metal or metal alloy layer. Subsequently, a photocatalytic substrate is then applied to the metal or metal alloy layer. The photocatalytic substrate eliminates bacteria, viruses and other harmful substances, as well as fine dust or fungal spores, when the optofluidic reactor is used. | 2014-06-26 |
20140179514 | RAPID AND ENHANCED ACTIVATION OF MICROPOROUS COORDINATION POLYMERS BY FLOWING SUPERCRITICAL CO2 - Flowing supercritical CO | 2014-06-26 |
20140179515 | COMPLEX OXIDE, METHOD FOR PRODUCING SAME, AND EXHAUST GAS PURIFICATION CATALYST - Provided are: a complex oxide that exhibits high redox ability even at low temperatures, has excellent heat resistance, and stably retains these characteristics even on repeated oxidation and reduction at high temperature; a method for producing the same; and an exhaust gas purification catalyst. The inventive complex oxide contains more than 0 but no more than 20 parts by mass of Si, calculated as SiO | 2014-06-26 |
20140179516 | CATALYST FOR PRODUCING ETHYLENE OXIDE, PROCESS FOR PRODUCING THE CATALYST AND PROCESS FOR PRODUCING ETHYLENE OXIDE - There is provided a catalyst for producing ethylene oxide from ethylene which is composed of at least silver (Ag), cesium (Cs), rhenium (Re) and a carrier, and can be improved, in particular, in selectivity. | 2014-06-26 |
20140179517 | AZOLE DERIVATIVE, METHOD FOR PRODUCING SAME, INTERMEDIATE COMPOUND, AND AGRICULTURAL OR HORTICULTURAL CHEMICAL AGENT AND INDUSTRIAL MATERIAL PROTECTING AGENT - Provided is an azole derivative superior in disease-controlling activity contained as an active ingredient in agricultural or horticultural chemical agents. | 2014-06-26 |
20140179518 | Pesticidal Mixtures Comprising Cyanosulfoximine Compounds - The present invention relates to pesticidal mixtures comprising as active components | 2014-06-26 |
20140179519 | N-THIO-ANTHRANILAMIDE COMPOUNDS AND THEIR USE AS PESTICIDES - The present invention relates to N-thio-anthranilamide compounds of the formula (I), the stereoisomers, the salts, the tautomers and the N-oxides thereof, | 2014-06-26 |
20140179520 | Humic Acid Composition - A humic acid composition useful as a fertilizer contains about 0.1 to 25 parts by weight humic acid dissolved in about 75 to 99.9 parts by weight of a solvent. The solvent contains at least one nonaqueous solvent. The composition has a pH of about 1 to 7 and a RED of less than about 1.0. | 2014-06-26 |
20140179521 | COMPOSITIONS INCORPORATING HYTd - Disclosed are compositions comprising a first component comprising chitosan, glucosamine and amino acids and a second component selected from the group consisting of (i) one or more pesticides, (ii) one or more non-pesticide organic molecules, (iii) one or more plant nutritional molecules and (iv) non-pesticidal living systems. The composition can also include trace elements, protein and other polysaccharides. The composition is generally a liquid but may be a solid. In most embodiments, the solid can be reconstituted with water prior to use. In the disclosed processes soil, seed, seedling or plant foliage is contacted with the disclosed compositions to produce beneficial results. | 2014-06-26 |
20140179522 | HERBICIDAL COMPOSITIONS COMPRISING 4-AMINO-3-CHLORO-6-(4-CHLORO-2-FLUORO-3-METHOXYPHENYL)-5-FLUOROPYRIDINE-2- -CARBOXYLIC ACID OR A DERIVATIVE THEREOF AND FLURTAMONE, DIFLUFENICAN, OR PICOLINAFEN - Provided herein are herbicidal compositions and methods employing combinations of (a) a compound of the formula (I) | 2014-06-26 |
20140179523 | HERBICIDAL COMPOSITIONS COMPRISING 4-AMINO-3-CHLORO-6-(4-CHLORO-2-FLUORO-3-METHOXYPHENYL) PYRIDINE-2-CARBOXYLIC ACID OR A DERIVATIVE THEREOF AND FLUFENACET - Provided herein are herbicidal compositions and methods utilizing a combination of herbicidally active ingredients, the combination comprising: (a) a compound of the formula (I) | 2014-06-26 |
20140179524 | HERBICIDAL COMPOSITIONS COMPRISING 4-AMINO-3-CHLORO-6-(4-CHLORO-2-FLUORO-3-METHOXYPHENYL) PYRIDINE-2-CARBOXYLIC ACID OR A DERIVATIVE THEREOF AND FLURTAMONE - Provided herein are herbicidal compositions and methods employing combinations of (a) a compound of formula (I): | 2014-06-26 |
20140179525 | HERBICIDAL COMPOSITIONS COMPRISING FLUROXYPYR AND FLUMETSULAM - Herbicidal compositions containing (a) fluoroxypyr or an agriculturally acceptable salt or ester thereof and (b) flumetsulam or an agriculturally acceptable salt thereof provide synergistic herbicidal control of undesirable vegetation, e.g., in wheat, barley, oats, rye, sugarcane, rice, sorghum, corn/maize, soybean, rice, sunflower, canola/oilseed rape, sugarcane, sorghum, cotton, pastures, grasslands, rangelands, fallowland, turf, tree and vine orchards, industrial vegetation management and rights-of-way; or crops comprising an aad-12 gene. Also provided herein are methods of using herbicidal compositions containing (a) fluoroxypyr or an agriculturally acceptable salt or ester thereof and (b) flumetsulam or an agriculturally acceptable salt thereof. | 2014-06-26 |
20140179526 | Temperature Stable Cloquintocet-Mexyl Aqueous Compositions - Temperature stable aqueous compositions and methods for their preparation and use are described. The compositions can include cloquintocet-mexyl, a surfactant comprising a tallowamine alkoxylate, a cocoamine alkoxylate, or a combination thereof, and water. | 2014-06-26 |
20140179527 | N-(TETRAZOL-5-YL)- AND N-(TRIAZOL-5-YL)ARYLCARBOXAMIDES AND USE THEREOF AS HERBICIDES - N-(Tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxamides of the general formula (I) are described as herbicides. | 2014-06-26 |
20140179528 | STRAIN BELONGING TO BACILLUS GENUS, MICROBIOLOGICAL AGENT, AND PLANT CULTIVATION METHOD - The present invention relates to the | 2014-06-26 |
20140179529 | AMINE AND AMINE OXIDE SURFACTANTS FOR CONTROLLING HERBICIDE SPRAY DRIFT - Spray drift during the application of an aqueous mixture of glyphosate and an auxinic herbicide is reduced by incorporating certain tertiary amine or tertiary amine oxide surfactants into the aqueous solution or mixture to be sprayed. | 2014-06-26 |
20140179530 | WEED CONTROL FROM APPLICATIONS OF AMINOPYRALID, TRICLOPYR, AND AN ORGANOSILICONE SURFACTANT - Disclosed herein are herbicidal compositions comprising a herbicidal effective amount of (a) aminopyralid, or an agriculturally acceptable salt or ester thereof, (b) triclopyr, or an agriculturally acceptable salt or ester thereof, and (c) an organosilicone surfactant. Also disclosed herein are methods of controlling undesirable vegetation, which comprise applying to vegetation or an area adjacent the vegetation or applying to soil or water to prevent the emergence or growth of vegetation (a) aminopyralid, or an agriculturally acceptable salt or ester thereof, (b) triclopyr, or an agriculturally acceptable salt or ester thereof, and (c) an organosilicone surfactant. | 2014-06-26 |
20140179531 | SYNERGISTIC WEED CONTROL FROM APPLICATIONS OF PENOXSULAM AND MEFENACET - Disclosed herein are herbicidal compositions comprising a synergistically herbicidal effective amount of (a) penoxsulam, or an agriculturally acceptable salt thereof, and (b) mefenacet, or an agriculturally acceptable salt thereof. Also disclosed herein are methods of controlling undesirable vegetation in rice, which comprise applying to vegetation or an area adjacent the vegetation or applying to soil or water to prevent the emergence or growth of vegetation (a) penoxsulam, or an agriculturally acceptable salt thereof, and (b) mefenacet, or an agriculturally acceptable salt thereof, wherein (a) and (b) are each added in an amount sufficient to produce a synergistic herbicidal effect. | 2014-06-26 |
20140179532 | Oligourea Compounds and Method for Producing Same and Use Thereof - The invention relates to a method for producing oligourea compounds by chain building and depolymerization, and to oligourea dispersions, as well as to their use as fungicides, biocides and/or herbicides. | 2014-06-26 |
20140179533 | METHOD AND FORMULATION FOR REMOVING FLORA FROM SEWER LINES - This invention relates to the application of herbicides in sewer liens to kill tree roots inside the lines and preventing re-growth into the lines for years after application. It relates to the discovery that latex polymers, organosilicone surfactants, deposition agents and other surfactants can be used to “glue” the herbicides to pipe surfaces. This discovery allows the use of plant killing herbicides to treat roots in sewer lines—killing them—which results in their subsequent removal by decay and erosion processes. It also allows for the use of the herbicides to prevent regrowth back into the sewer lines by applying the herbicides in a compound which adheres to the sewer line surfaces and forms a long term coating on the pipe and joint surfaces where the roots might attempt to grow back in. The compound resists erosion and washing away preventing long term root re-infestations in the sewer lines. | 2014-06-26 |
20140179534 | HERBICIDE-RESISTANT PROTEINS, ENCODING GENES, AND USES THEREOF - Some embodiments of the present invention can include herbicide-resistant proteins, coding genes, and uses thereof. Certain herbicide-resistant proteins can comprises: (a) a protein consisting of an amino acid sequence shown in SEQ ID NO: 2; or (b) a protein consisting of an amino acid sequence at least 90% identical to that set forth in SEQ ID NO: 2. Other herbicide-resistant proteins of this disclosure can be suitable for expression in plants, can have resistance to herbicides (e.g., to phenoxy auxinherbicides), or both. | 2014-06-26 |
20140179535 | ELECTRIC DRIVE DEVICE FOR AN AIRCRAFT - The invention relates to a drive device for an aircraft ( | 2014-06-26 |
20140179536 | Genetic Diagnosis of Hepatic Steatosis - Disclosed are methods of identifying a genetic variant in a person determined to have or be predisposed having a fatty liver by determining whether the person has PNPLA3-I148M. Also disclosed are methods of identifying a genetic variant in a person by determining whether the person has PNPLA3-I148M; and prescribing to the person a treatment to reduce liver fat or associated inflammation. | 2014-06-26 |
20140179537 | COMPOSITIONS AND METHODS FOR DIAGNOSING COLON DISORDERS - The present invention relates to methods and compositions for diagnosing, monitoring, prognosticating, analyzing, etc., polymicrobial diseases. The present invention also relates to the microbial community present in the digestive tract and lumen in normal subjects, and subjects with digestive tract diseases, especially diseases of the colon, such as inflammatory bowel disease, including ulcerative colitis, Crohn's syndrome, and pouchitis. The present invention especially relates to compositions and methods for diagnosing and prognosticating the mentioned diseases and conditions, e.g., to determine the presence of the disease in a subject, to determine a therapeutic regimen, to determine a therapeutic regimen, to determine the onset of active disease, to determine the predisposition to the disease, etc. | 2014-06-26 |
20140179538 | MUTATIONS IN PANCREATIC NEOPLASMS - To help reveal the pathogenesis of these lesions, we purified the DNA from Intraductal Papillary Mucinous Neoplasm (IPMN) cyst fluids from 19 patients and searched for mutations in 169 genes commonly altered in human cancers. We identified recurrent mutations at codon 201 of GNAS. We found that GNAS mutations were present in 66% of IPMNs and that either KRAS or GNAS mutations could be identified in 96%. In eight cases, we could investigate invasive adenocarcinomas that developed in association with IPMNs containing GNAS mutations. In seven of these eight cases, the GNAS mutations present in the IPMNs were also found in the invasive lesion. GNAS mutations were not found in other types of cystic neoplasms of the pancreas or in invasive adenocarcinomas not associated with IPMNs. These data suggest that GNAS mutations can inform the diagnosis and management of patients with cystic pancreatic lesions. | 2014-06-26 |
20140179539 | Novel Ligase Activity - Compositions and methods are provided for ligating polynucleotides having a length that is greater than 8 nucleotides on an RNA splint. The ligation reaction provides consistent results in high or low ATP concentrations. The reaction can occur rapidly and is generally at least 10 fold more efficient than T4DNA ligase under optimal conditions for T4DNA ligase and the reaction time is less than 6 hours for example, less than 1 hour. | 2014-06-26 |
20140179540 | MODIFYING PROTEINS (GPCR), LIGANDS, AND NANOPORE SURFACES TO ALLOW THE DETECTION OF CREATE BINDING-INDUCED MOLECULAR CHANGES OF PROTEIN-LIGAND COMPLEXES WITH NANOCHANNEL TRANSLOCATION - A mechanism is provided for utilizing a nanodevice to distinguish molecules with different structure. The molecules translocate through or across a nanochannel filled with a electrolyte solution. An electrical signal through the nanochannel is measured for every translocation event. Inner surfaces of the nanochannel include a functional layer, which is a coating to functionalize the nanochannel, in which the functional layer is configured to interact with predetermined ones of the molecules during translocation events. It is determined that a combination of at least two different molecules is formed based on predetermined ones of the molecules interacting with the functional layer to change the electrical signal and/or change a translocation time for the translocation event. | 2014-06-26 |
20140179541 | MODIFYING SINGLE PROTEINS (GPCR), LIGANDS, AND NANOPORE SURFACES TO CREATE BINDING-INDUCED MOLECULAR CHANGES OF PROTEIN-LIGAND COMPLEXES DETECTED IN NANOCHANNEL TRANSLOCATION - A mechanism is provided for utilizing a nanodevice to distinguish molecules with different structure. The molecules translocate through or across a nanochannel filled with a electrolyte solution. An electrical signal through the nanochannel is measured for every translocation event. Inner surfaces of the nanochannel include a functional layer, which is a coating to functionalize the nanochannel, in which the functional layer is configured to interact with predetermined ones of the molecules during translocation events. It is determined that a combination of at least two different molecules is formed based on predetermined ones of the molecules interacting with the functional layer to change the electrical signal and/or change a translocation time for the translocation event. | 2014-06-26 |
20140179542 | METHODS FOR RAPIDLY IDENTIFYING SMALL ORGANIC MOLECULE LIGANDS FOR BINDING TO BIOLOGICAL TARGET MOLECULES - The present invention is directed to novel methods for rapidly and unambiguously identifying small organic molecule ligands for binding to biological target molecules. Small organic molecule ligands identified according to the methods of the present invention may find use, for example, as novel therapeutic drug lead compounds, enzyme inhibitors, labeling compounds, diagnostic reagents, affinity reagents for protein purification, and the like. Also presented are novel methods for identifying high affinity binding ligands for a biological target molecule of interest, wherein those methods comprise linking two or more small organic molecule ligands previously identified as being capable of binding to the biological target molecule of interest. Biological target molecules include, for example, polypeptides, nucleic acids, carbohydrates, nucleoproteins, glycoproteins, glycolipids and lipoproteins. | 2014-06-26 |
20140179543 | IDENTIFICATION OF SMALL-MOLECULE CANDIDATE THERAPEUTICS CAPABLE OF INHIBITING OR INTERFERING WITH A TARGET PROTEIN-PROTEIN INTERACTION - The present invention provides a method of screening method small-molecule candidate therapeutics capable of inhibiting or interfering with intracellular protein-protein interactions, such as cancer associated oncogenic protein interactions and in particular RAS and LMO2 protein-protein interactions. The present invention also provides methods and assays for rationalized drug design based on identifying small molecular weight protein-protein interaction inhibitor molecules that emulate antibody therapeutics products. | 2014-06-26 |
20140179544 | COMPOSITIONS, SYSTEMS AND METHODS FOR DROPLET FORMATION, SPACING AND DETECTION - The present disclosure provides assays and devices for forming, spacing, and/or detecting droplets. The droplets may be emulsions composed of two or more immiscible fluids. An emulsion can be a double emulsion, such as water-in-oil droplets that are present in a continuous aqueous phase. The double emulsion can be formed when the water-in-oil droplets are contacted with one or more streams of aqueous fluid(s). This disclosure also provides a variety of additives that can be added to the fluids. | 2014-06-26 |
20140179545 | Diagnosis, Prognosis and Identification of Potential Therapeutic Targets of Multiple Myeloma Based on Gene Expression Profiling - Gene expression profiling is a powerful tool that has varied utility. It enables classification of multiple myeloma into subtypes and identifying genes directly involved in disease pathogensis and clinical manifestation. The present invention used gene expression profiling in large uniformly treated population of patients with myeloma to identify genes associated with poor prognosis. It also demonstrated that over-expression of CKS1B gene, mainly due to gene amplification that was determined by Fluorescent in-situ hybridization to impart a poor prognosis in multiple myleoma. It is further contemplated that therapeutic strategies that directly target CKS1B or related pathways may represent novel, and more specific means of treating high risk myeloma and may prevent its secondary evolution. | 2014-06-26 |
20140179546 | GENETIC VARIANTS ON CHR 5P12 AND 10Q26 AS MARKERS FOR USE IN BREAST CANCER RISK ASSESSMENT, DIAGNOSIS, PROGNOSIS AND TREATMENT - The invention pertains to certain genetic variants on Chr5p12 and Chr10q26 as susceptibility variants of breast cancer. Methods of disease management, including diagnosing increased and/or decreased susceptibility to breast cancer, methods of predicting response to therapy and methods of predicting prognosis using such variants are described. The invention further relates to kits useful in the methods of the invention. | 2014-06-26 |
20140179547 | Methods For The Generation Of Multispecific And Multivalent Antibodies - The invention provides novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule and methods for producing novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule. The antibodies are composed of a single heavy chain and two different light chains, one containing a Kappa constant domain and the other of a Lambda constant domain. The invention provides methods for the isolation of antibodies of different specificities but sharing a common heavy chain. The invention also provides methods for the controlled co-expression of two light chains and a single heavy chain leading to the assembly of monospecific and bispecific antibodies. The invention provides a mean of producing a fully human bispecific and bivalent antibody that is unaltered in sequence and does not involve the use of linkers or other non-human sequences, as well as antibody mixtures of two monospecific antibodies and one bispecific antibody. The invention also provides the means of efficiently purifying the bispecific antibody. | 2014-06-26 |
20140179548 | MOLECULAR PROGNOSTIC SIGNATURE FOR PREDICTING BREAST CANCER METASTASIS, AND USES THEREOF - The present invention is based on the discovery of a unique 14-gene molecular prognostic signature that is useful for predicting breast cancer metastasis. In particular, the present invention relates to methods and reagents for detecting and profiling the expression levels of these genes, and methods of using the expression level information in predicting risk of breast cancer metastasis. | 2014-06-26 |
20140179549 | METHODS FOR IDENTIFYING INFLAMMATORY BOWEL DISEASE PATIENTS WITH DYSPLASIA OR CANCER - The present invention provides methods for identifying IBD patients with dysplasia or cancer. In particular embodiments, the methods of the invention may comprise determining the presence or level of at least one or a panel of miRNAs in a sample obtained from an IBD patient to establish a miRNA expression profile, and comparing the miRNA expression profile with one or more pre-established model miRNA expression profiles. The present invention further provides methods for monitoring the efficacy of treatment of IBD patients with dysplasia or cancer. | 2014-06-26 |
20140179550 | IMMUNOGLOBULIN FC LIBRARIES - Methods and composition for the screening and isolation of aglycosylated antibody Fc domain polypeptides. For example, in certain aspects methods for identifying aglycosylated Fc domains that bind to Fc receptors or preferentially bind to particular Fc receptors are described. Furthermore, the invention provides aglycosylated Fc domains that bind to Fc receptors with high affinity. Enhanced methods and media for prokaryotic based interaction screening are also provided. | 2014-06-26 |
20140179551 | METHODS FOR THE SELECTION OF BINDING PROTEINS - This application provides an improved screening method for the selection of target-binding proteins having desirable biophysical properties. The method combines mRNA display and yeast surface display in a way that takes advantage of the desirable attributes of both processes. | 2014-06-26 |
20140179552 | METHODS AND COMPOSITIONS FOR DIAGNOSING OSTEOARTHRITIS IN A FELINE - Methods, compositions and kits for diagnosing osteoarthritis in a feline are disclosed. The methods of the invention comprise detecting differential expression of at least one biomarker in a body sample, preferably a blood sample, where the biomarker is differentially expressed in osteoarthritis. | 2014-06-26 |
20140179553 | MERCURY METHYLATION GENES IN BACTERIA AND ARCHAEA - Two genes required for this mercury methylation have been identified in bacteria and archaea. These genes are the hgcA gene and hgcB, a corrinoid protein that facilitates methyl group transfer to Hg, and a corrinoid protein-associated ferredoxin with two [4Fe-4S] binding motifs involved in generating cob(I)almin, respectively. The invention provides nucleic acid probes and primers for detecting methylmercury and or for assessing mercury methylation potential in environmental, clinical and other samples. The invention also provides antibodies against these proteins, antibodies against these proteins, methods of using the antibodies and methods of biocatalysis. | 2014-06-26 |
20140179554 | Microarrays - Provided herein are microarrays (protein and/or nucleic acid microarrays) containing an array of spots on a solid substrate, wherein the spots are arranged to reduce the risk of array misalignment and/or to facilitate the visual interpretation of an array image by a human operator. Also provided herein are methods of using such arrays and kits containing such arrays. | 2014-06-26 |
20140179555 | SELF-ENCODING SENSOR WITH MICROSPHERES - Disclosed herein are compositions and methods for combining the output obtained from redundant sensor elements in a sensor array. | 2014-06-26 |
20140179556 | Method for Identifying Lineage-Related Antibodies - In certain embodiments, the method may comprise: a) obtaining the antibody sequences from a population of B cells; b) grouping the antibody sequences to provide a plurality of groups of lineage-related antibodies; c) testing a single antibody from each of the groups in a bioassay and, after the first antibody has been identified, d) testing further antibodies that are in the same group as the first antibody in a second bioassay. In another embodiment, the method may comprise: a) testing a plurality of antibodies obtained from a first portion of an antibody producing organ of an animal; b) obtaining the sequence of a first identified antibody; c) obtaining from a second portion of said antibody producing organ the sequences of further antibodies that are related by lineage to said first antibody; and, c) testing the further antibodies in a second bioassay. | 2014-06-26 |
20140179557 | MARKER SEQUENCES FOR DIAGNOSING PROSTATE CANCER, AND USE THEREOF - The present invention relates to novel marker sequences for prostate carcinoma while excluding inflammatory prostate diseases or diabetes or polymorbidity and relates to their diagnostic use including a method for screening potential active substances for such prostate diseases by means of these marker sequences. The invention furthermore relates to a diagnostic device including such marker sequences for prostate carcinoma, in particular a protein biochip and its use. | 2014-06-26 |
20140179558 | METHOD FOR DETECTING PANCREATIC CANCER - This invention relates to a method for detecting pancreatic cancer using novel tumor markers. Specifically, the invention provides a method for detecting pancreatic cancer comprising measuring the presence or an amount of a polypeptide having an reactivity of binding via an antigen-antibody reaction to an antibody against CAPRIN-1 protein in a sample separated from a subject, and to a reagent or kit for detecting pancreatic cancer comprising a CAPRIN-1 protein or a fragment thereof, an antibody against the same, or a polynucleotide encoding the same. | 2014-06-26 |
20140179559 | COMPUTER-IMPLEMENTED METHOD FOR IDENTIFYING DIFFERENTIALLY EXPRESSED GENES AND COMPUTER READABLE STORAGE MEDIUM FOR STORING THE METHOD - A method for identifying differentially expressed genes including the following steps: measure gene expression levels of test samples and control samples; estimate variances of noise in the test samples and in the control samples; based on the measured expression levels and the estimated variances of noise, derive a probability density function (PDF) for predicting the true value of each expression level measurement; normalize the PDFs; based on the normalized PDFs of the gene under test, derive a test-group PDF for predicting the gene's mean expression level in the test samples and derive a control-group PDF for predicting the gene's mean expression level in the control samples; based on the test-group PDF and the control-group PDF of the gene under test, derive a final PDF for predicting the gene's fold-change; use the final PDF to test whether the gene is differentially expressed. | 2014-06-26 |
20140179560 | DRUG DISCOVERY METHODS AND PLATFORMS - Methods and systems for discovering drug candidates are disclosed. Methods and systems can include generating libraries of potential drug candidates (e.g., libraries of peptides) that can be screened to identify sub-libraries of potential drug candidates (e.g., sub-libraries of peptides) having selected pharmacological properties. Methods of making and using peptide libraries are also provided. D-amino acid chlorotoxins and D-amino acid chlorotoxin variants are also provided. | 2014-06-26 |
20140179561 | HANGING DROP DEVICES, SYSTEMS AND/OR METHODS - The present disclosure relates general to devices, systems, and methods of using such devices in creating and handling hanging drops of fluid. The present disclosure also relates to cell culture devices, methods and/or systems of using such devices as well as the use of cell culture devices, for example, for research and high throughput screening. | 2014-06-26 |
20140179562 | METHODS AND KITS FOR 3'-END-TAGGING OF RNA - The present innovation provides methods and kits that enable rapid and efficient dual end-tagging of RNA to prepare libraries for analysis by applications such as next-generation RNA sequencing, qPCR, microarray analysis, or cloning. The methods do not require time-consuming and inefficient gel-purification steps that are common to methods known in the art. In addition, the present invention provides methods and kits for rapid, high-throughput enzymatic preparation of 5′-activated, 3′-blocked DNA oligonucleotides from standard, single-stranded DNA oligonucleotides. | 2014-06-26 |
20140179563 | Method and Nucleic Acids for the Analysis of Colorectal Cell Proliferative Disorders - The invention provides methods and nucleic acids for detecting, differentiating or distinguishing between colon cell proliferative disorders as well as therapy thereof by analysis of the gene EYA4 and its promoter and regulatory sequences. The invention further provides novel nucleic acid sequences useful for the cell proliferative disorder specific analysis of said gene as well as methods, assays and kits thereof. | 2014-06-26 |
20140179564 | COMPOSITIONS AND METHODS FOR SELECTION OF NUCLEIC ACIDS CONTAINING MODIFIED BASES - Methods are provided for reducing the complexity of a population of nucleic acids prior to performing an analysis of the nucleic acids, e.g., sequence analysis. The methods result in a subset of the initial population enriched for a desired property, or lacking nucleic acids having an undesired property. The methods are particularly useful for analyzing populations having a high degree of complexity, e.g., chromosomal-derived DNA, whole genomic DNA, or mRNA populations. In addition, such methods allow for analysis of pooled samples. | 2014-06-26 |
20140179565 | POST-SYNTHESIS PROCESSING SYSTEM FOR SUPPORTED OLIGONUCLEOTIDES, AND METHOD - A system is provided that can include: a plurality of retainment regions, where each retainment region is adapted to retain a respective type of an oligonucleotide supported on a respective support; a mixture retainment region; a handling device; a control unit adapted to control the handling device; and a separating unit adapted to simultaneously separate different supported oligonucleotides from their respective supports. A method is provided that can include: pooling together a plurality of supported oligonucleotides to form a mixture; and simultaneously separating the oligonucleotides of the supported oligonucleotides in the mixture from their supports. A method for facilitating genetic analysis is also provided and can include: receiving from a user a request for one or more genetic analysis assays; formulating each assay; and providing to the user the one or more assay; wherein the formulating can include pooling together into a mixture retainment region a plurality of different supported oligonucleotides and simultaneously separating the different oligonucleotides from their respective supports. | 2014-06-26 |
20140179566 | Thermal Cycling Apparatus and Method - A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent. | 2014-06-26 |
20140179567 | REVERSIBLY COAGULATABLE AND REDISPERSABLE POLYMER INCLUDING AT LEAST ONE MONOMER INCLUDING A SWITCHABLE-AMPHIPHILIC FUNCTIONAL GROUP AND METHODS OF USING THE SAME - The present invention relates to a polymer including at least one monomer comprising a switchable-amphiphilic functional group. Various embodiments provide a methods of treating a subterranean formation with the polymer, compositions including the polymer, and methods of making compositions including the polymer. | 2014-06-26 |
20140179568 | Method of Using Dithiazines and Derivatives Thereof in the Treatment of Wells - Corrosion of metallic tubulars in an oil, gas or geothermal well may be inhibited by introducing into the well a dithiazine derivative of the formula: | 2014-06-26 |
20140179569 | AGENT FOR MIXING INTO A SERVICE FLUID FOR A TECHNICAL LAYOUT, CONCENTRATE FOR MIXING INTO A SERVICE FLUID FOR A TECHNICAL LAYOUT, AND THE SERVICE FLUID - The invention concerns an agent for mixing into a service fluid for a technical layout, a concentrate for mixing into a service fluid for a technical layout, and a service fluid. An agent according to the invention contains at least one ingredient A chosen from the group of three-layer silicates, at least one ingredient B chosen from the group consisting of bentonites, pyrogenic silicic acids, and talc, and graphite. | 2014-06-26 |
20140179570 | ADDITIVE COMPOSITIONS WITH A FRICTION MODIFIER AND A DISPERSANT - A lubricating composition comprising a major amount of base oil and a minor amount of an additive package, wherein the additive package comprises
| 2014-06-26 |
20140179571 | FRICTION MODIFIERS FOR LUBRICATING OILS - A lubricating oil comprises a major amount of a base oil and a minor amount of an additive package, and the additive package comprises at least one friction modifier of formula I: | 2014-06-26 |
20140179572 | ADDITIVE COMPOSITIONS WITH PLURAL FRICTION MODIFIERS - A lubricating oil comprising a major amount of base oil and a minor amount of an additive package, wherein the additive package comprises: | 2014-06-26 |
20140179573 | POST-TREATED MOLYBDENUM IMIDE ADDITIVE COMPOSITION, METHODS OF MAKING SAME AND LUBRICATING OIL COMPOSITIONS CONTAINING SAME. - The invention is directed to an embodiment of the present invention is directed to an oil soluble additive composition prepared by a process comprising: reacting, (a) a molybdenum component; (b) an imide derived from the reaction product of a hydrocarbyl dicarboxylic acid component and a polyamine wherein said reaction product is prepared by first charging a polyamine to a reaction vessel and then charging a hydrocarbyl dicarboxylic acid component to the reaction vessel, wherein the charge mole ratio of the hydrocarbyl dicarboxylic acid component to the polyamine is from about 1:1 to about 1:0.5; and (c) a post-treating agent, thereby producing a post-treated moblydated succinimide additive composition. | 2014-06-26 |
20140179574 | Overbased Friction Modifiers and Methods of Use Thereof - The present invention provides a multipurpose overbased metal salt of the reaction product of a hydrocarbyl substituted amine with an itaconate, such as an N-substituted 4-carboxypyrrolidin-2-one, and methods of employing the same in lubricating compositions. Overbasing the N-substituted 4-carboxypyrrolidin-2-one can provide improved friction modifying performance to the compound as well as impart multi-functionality to the compound, i.e., the compound may function as a friction modifier as well as, for example, a detergent, anti-wear or extreme pressure agent and dispersant in lubricating compositions. The lubricating compositions containing the overbased N-substituted 4-carboxypyrrolidin-2-one are preferably intended to be employed in a method for lubricating a mechanical device, such as an automatic or manual transmission. However, it is envisioned that the compound can be employed in engine oil lubricants and any other type of functional fluid. | 2014-06-26 |
20140179575 | LUBRICANT COMPOSITIONS CONTAINING LINDQVIST METALATES - A lubricating composition comprises a major amount of a base oil, and an additive comprising a polyoxo Lindqvist ion of formula [M1 | 2014-06-26 |
20140179576 | ADDITIVE COMPOSITIONS WITH A FRICTION MODIFIER AND A METAL DIALKYL DITHIO PHOSPHATE SALT - A lubricating composition comprising a major amount of base oil and a minor amount of an additive package, wherein the additive package comprises: (A) a friction modifier component selected from:
| 2014-06-26 |
20140179577 | ADDITIVE COMPOSITIONS WITH A FRICTION MODIFIER AND A DETERGENT - A lubricating composition comprising a major amount of base oil and a minor amount of an additive package, wherein the additive package comprises (A) a friction modifier component selected from:
| 2014-06-26 |
20140179578 | ALTERNATING BLOCK COPOLYMER AND PROCESS FOR MAKING - Provided is an alternating block copolymer. The alternating block copolymer has an olefin polymer block and an poly(alkyl methacrylate) block. The olefin polymer block has monomeric units of one or more alpha olefins of 2 to 12 carbon atoms that make up 90 wt % or more of the total weight of the olefin polymer block. The olefin polymer block exhibits a number average molecular weight of the olefin polymer block is 1000 to 500,000. The poly(alkyl methacrylate) block has monomeric units of one or more alkyl methacrylates with alkyl side chains of 1 to 100 carbon atoms that make up 90 wt % or more of the total weight of the poly(alkyl methacrylate) block. The poly(alkyl methacrylate) block exhibits a number average molecular weight of 1000 to 500,000. There is also provided a lubricant composition containing the alternating block copolymer and a process for making the alternating block copolymer. | 2014-06-26 |
20140179579 | FRICTION MODIFIERS FOR USE IN LUBRICATING OIL COMPOSITIONS - A lubricating oil comprising a major amount of base oil and a minor amount of an additive package comprising a friction modifier component selected from:
| 2014-06-26 |
20140179580 | AGENT FOR OBTAINING A STABLE AQUEOUS COMPOSITION COMPRISING PARTICLES IN SUSPENSION - Agent for obtaining a stable aqueous composition comprising an association:
| 2014-06-26 |
20140179581 | SKIN CLEANSING COSMETIC COMPOSITION CONTAINING VEGETABLE OILS, METHOD FOR PRODUCING SAID COMPOSITION AND USE OF SAID COMPOSITION - The present invention relates to a cosmetic composition, particularly indicated for skin cleaning, which comprises:
| 2014-06-26 |
20140179582 | METHODS AND COMPOSITIONS FOR REMOVAL OF METAL HARDMASKS - The invention provides a process for removing a film from a substrate, said process comprising applying a composition to the film, and
| 2014-06-26 |
20140179583 | PEELING LIQUID FOR A RESIST - The invention discloses a peeling liquid for a resist, which relates to an optical element and is used for removing the color resist and the protective layer on a color filter rapidly and efficiently. The peeling liquid for a color resist on a color filter comprises an alkali metal alkoxide with a mass percentage of 10-45%, an organic amine with a mass percentage of 10-30%, a surfactant with a mass percentage of 5-30%, a solvent with a mass percentage of 20-60%, and an alcohol with a mass percentage of 1-55% in terms of the peeling liquid for a resist with a mass percentage of 100%. The peeling liquid for a resist in invention is used for removing the color resist and the protective layer of the substandard product in a color filter. | 2014-06-26 |
20140179584 | DETERGENT PRODUCTS, METHODS AND MANUFACTURE - A water-soluble pouch suitable for use in machine dishwashing and which comprises a plurality of compartments in generally superposed or superposable relationship, each containing one or more detergent active or auxiliary components, and wherein the pouch has a volume of from about 5 to about 70 ml and a longitudinal/transverse aspect ratio in the range from about 2:1 to about 1:8, preferably from about 1:1 to about 1:4. The water-soluble pouch allows for optimum delivery of dishwashing detergent. A process for the manufacture of multi-compartment pouches and a pack to contain the pouches are also disclosed. | 2014-06-26 |
20140179585 | DETERGENT COMPOSITION WITH SILICATE COATED BLEACH - A phosphate-free automatic dishwashing detergent composition containing a coated bleach particle and one or more of an enzyme particle or an amino-acid based builder, wherein the composition has increased stability. | 2014-06-26 |
20140179586 | CLEANING PACK - Multi-compartment water-soluble pack comprising a cleaning composition and an enveloping material where the pack comprises a first compartment containing a first composition in liquid form comprising:
| 2014-06-26 |
20140179587 | LAUNDRY SCENT ADDITIVE - A laundry scent additive having polyethylene glycol and perfume. The laundry scent additive enables consumers to control the amount of scent imparted to their laundry. | 2014-06-26 |
20140179588 | Polypeptides Having Cellulase Activity and Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having cellulase activity. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2014-06-26 |
20140179589 | PROCESS FOR THE PRODUCTION OF A LIQUID COMPOSITION - A process for the production of a liquid detergent composition comprising the steps of: providing an aqueous solution free of perfumes through a main stream; providing a second solution comprising at least one perfume and at least one material selected from the group consisting of surfactants, organic solvents, carboxylic acids, and mixtures thereof, through a first side stream, wherein the ratio of said perfume to said at least one material is from 0.05 to 0.5; providing at least a third solution comprising at least one aesthetic component and/or finishing component, through at least one second side stream; and mixing the solutions to provide the liquid detergent composition. The second solution is mixed with the aqueous solution at a first confluence region of said main and first side streams and the at least third solution is mixed therewith at, at least one, second confluence region, said at least one second confluence region being downstream said first confluence region. | 2014-06-26 |
20140179590 | POLYMERIC AGENT FOR OBTAINING A STABLE AQUEOUS COMPOSITION COMPRISING PARTICLES IN SUSPENSION - Agent for obtaining a stable aqueous composition comprising a polymer constituted of:
| 2014-06-26 |
20140179591 | STRUCTURING USING AN EXTERNAL STRUCTURANT AND A COSMOTROPE - The structuring ability of fluid compositions comprising an amido-gellant or HEUR polymeric structurant can be improved with the addition of a cosmotrope. | 2014-06-26 |
20140179592 | Compounds - The present invention relates to compounds, and pharmaceutically acceptable salts thereof, comprising a vascular disrupting agent (VDA) associated and a MMP proteolytic cleavage site. The compounds are useful in the treatment of cancer. | 2014-06-26 |
20140179593 | METHODS AND COMPOSITIONS FOR INHIBITING NEDDYLATION OF PROTEINS - Provided herein is a novel binding pocket within NEDD8 co-E3 proteins that binds NEDD8 E2 enzymes. Particularly at its M-Terminus. Methods are provided for screening for compounds that bind to the disclosed E2-binding pocket in NEDD8 co-E3 proteins. Compounds that bind to the E2-binding pocket and optionally inhibit the activity of NEDD8 co-E3 proteins and pharmaceutical compositions comprising the same are further provided. The NEDD8 co-E3 inhibitors find use, as agents preventing the NEDDylation of a target protein, in inhibiting cell growth and methods for treating cancers, inflammatory disorders, and pathogenic infections. The preferred inhibitors are peptides corresponding to a M-terminal fragment of Dnc1, e.g. MTLASKLKRDD, MLKLRQLQKKKQ, and MIKLFSLKQQKK, which are substituted at the M-Terminus with an uncharged group (e.g. acyl). | 2014-06-26 |
20140179594 | STREPTOCOCCUS BACTERIOPHAGE LYSINS FOR TREATMENT OF GRAM POSITIVE BACTERIA IN COMPANION ANIMALS AND LIVESTOCK - The present invention provides methods for the prophylactic and therapeutic amelioration and treatment of gram-positive bacteria in companion animals and livestock, including | 2014-06-26 |
20140179595 | APOLIPOPROTEIN E POLYPEPTIDES AND THEIR USE - Disclosed herein are several apoplipoprotein E (ApoE) polypeptides, and nucleic acids encoding these polypeptides, that can be used to treat or prevent a hepatitis infection in a subject, such as a hepatitis C virus infection. These ApoE polypeptides can inhibit the entry of hepatitis C virus into cells, and inhibit viral replication. Nucleic acids encoding these polypeptides are also disclosed, as well as methods | 2014-06-26 |
20140179596 | ALBUMIN FUSION PROTEINS - Provided herein are albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins and vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins and using these nucleic acids, vectors, and/or host cells also are provided. Further described are pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention. | 2014-06-26 |
20140179597 | Method for the treatment and prevention of Alzheimer's disease and central nervous system dysfunction - Intranasal insulin is beneficial for the treatment of Alzheimer's disease and other neurologic disorders. But commercial insulin preparations use metacresol, phenol, and other preservatives for chemical stabilization. Metacresol in particular has multiple toxic effects when administered long term, especially intranasal. These effects include rhinitis and nosebleeds. The present invention teaches the use of intranasal insulin not preserved with meta-cresol, phenol or other excipients for the treatment of Alzheimer's disease and other neurologic disorders. | 2014-06-26 |
20140179598 | SOMATOSTATIN ANALOGS WITH INHIBITORY ACTIVITY TO GROWTH HORMONE RELEASE - Provided are therapeutic and diagnostic somatostatin analogs including radiotherapeutic and radiodiagnostic reagents, and methods of making and use thereof. | 2014-06-26 |
20140179599 | STABLE FORMULATIONS FOR PARENTERAL INJECTION OF PEPTIDE DRUGS - Stable formulations for parenteral injection of peptide drugs and methods of using such stable formulations are provided. In particular, the present invention provides stable formulations for parenteral injection of glucagon and methods of using such glucagon formulations to treat hypoglycemia, especially severe hypoglycemia in emergency situations. | 2014-06-26 |
20140179600 | STABLE FORMULATIONS FOR PARENTERAL INJECTION OF PEPTIDE DRUGS - Stable formulations for parenteral injection of peptide drugs and methods of using such stable formulations are provided. In particular, the present invention provides stable formulations for parenteral injection of glucagon and methods of using such glucagon formulations to treat hypoglycemia, especially severe hypoglycemia in emergency situations. | 2014-06-26 |
20140179601 | FGF-9 AND ITS USE RELATING TO BLOOD VESSELS - There is provided a composition for controlling formation and/or stabilization of a blood vessel comprising a first isolated nucleic acid molecule that encodes a FGF-9 polypeptide and optionally one or more isolated nucleic acid molecule that encodes another angiogenic polypeptide. There is provided a composition for controlling formation and/or stabilization of a blood vessel comprising administering an effective amount of a composition comprising an isolated FGF-9 polypeptide and one or more other angiogenic polypeptides. The compositions provided herein may be useful for controlling angiogenesis and/or vasculogenesis. | 2014-06-26 |
20140179602 | Viral Inactivated Biological Mixture - The invention relates to a viral inactivated biological liquid or dry mixture and to its preparation. Principally, the invention relates, but is not limited, to a mixture derived from a platelet source. | 2014-06-26 |
20140179603 | Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. | 2014-06-26 |
20140179604 | GHRH AGONISTS FOR THE TREATMENT OF ISCHEMIC DISORDERS - Disclosed herein are compositions of GHRH agonists and peptides, and methods to treat disorders, such as ischemia and reperfusion injury. In one embodiment, a method of treating a reperfusion injury in a subject in need may involve administering a therapeutically effective amount of at least one GHRH agonist peptide to the subject. In additional embodiment, a method of promoting vasculogenesis in a mammal may involve administering a therapeutically effective amount of at least one GHRH agonist peptide to the subject. In a further embodiment, a method of promoting differentiation of mesenchymal stem cells into endothelial cells may involve contacting mesenchymal stem cells with at least one GHRH agonist peptide. | 2014-06-26 |
20140179605 | NATRIURETIC POLYPEPTIDE DELIVERY SYSTEMS - This document provides natriuretic polypeptide delivery systems. For example, methods and materials related to natriuretic polypeptide delivery systems, methods and materials related to the use of such delivery systems to deliver natriuretic polypeptides to a mammal over a pro-longed period of time (e.g., weeks to months), and methods and materials related to treating heart failure conditions are provided. | 2014-06-26 |
20140179606 | LEFT VENTRICULAR DIASTOLIC FUNCTION IMPROVING AGENT - An agent for treating heart failure, which improves left ventricular diastolic function itself without depending on the diuretic effect or vasodilation effect; controls the pathological condition of diastolic functional failure; and prevents the recurrence, and can prevent dyspnea and death from the pathological condition, is provided. | 2014-06-26 |
20140179607 | Treatments for Gastrointestinal Disorders - The present invention provides peptides that are useful for the treatment of gastrointestinal disorders. The present invention also provides compositions and methods of treating gastrointestinal disorders and pharmaceutical compositions for accomplishing the same. In some embodiments, these pharmaceutical compositions include oral dosage forms. | 2014-06-26 |