26th week of 2016 patent applcation highlights part 23 |
Patent application number | Title | Published |
20160185655 | Low Dielectric Glass and Fiber Glass - Glass compositions are provided that are useful in a variety of applications including, for example, electronics applications, reinforcement applications, and others. Some embodiments of glass compositions can provide desirable dielectric constants, desirable dissipation factors, and/or desirable mechanical properties while also having desirable fiber forming properties. | 2016-06-30 |
20160185656 | AUTOMOTIVE GLAZING WITH ENAMEL PATTERNS - The invention concerns automobile glazing comprising an enamel coating on at least part of the surface thereof, said coating acting as a barrier against light transmission. The glazing is characterised in that the enamel coating reflects more than 10%, and preferably more than 15%, of wavelengths higher than 800 nm. | 2016-06-30 |
20160185657 | Method Of Forming Durable Glass Enamel - A multi-layer glass enamel is disclosed. The various layers of the enamel are included to provide certain performance characteristics to the enamel. The components of each layer can be individually adjusted to tailor the performance characteristics influenced by that layer without changing the influence of the remaining layers. | 2016-06-30 |
20160185658 | METHOD FOR MANUFACTURING ANTIFOGGING POROUS SILICA THIN FILM - A method for manufacturing an antifogging porous silica thin film includes preparing a silicon block copolymer micelle solution, forming a coating layer by applying the solution on a substrate using a compressed air spraying method, forming a porous silica thin film by subjecting the coating layer to an oxygen plasma treatment, and solvent-annealing the porous silica thin film. | 2016-06-30 |
20160185659 | COMPOSITION OF FINGERPRINT-RESISTANT LAYER CONSISTING OF A PLURALITY OF THIN FILMS AND PREPARATION METHOD THEREFOR - A composition for primer layer coating of a water- and oil-repellent coating layer so as to enhance the durability of the water- and oil-repellent coating layer, comprises a mixture which comprises at least one of a silicon oxide (SiOx) and titanium (Ti) compound, an aluminum (Al) compound and a zirconium (Zr) compound. A preparation method may comprise: preparing a glass or polymer substrate; forming, on the substrate, a portion on which a fingerprint-resistant layer is to be deposited within the substrate by etching; depositing a primer layer consisting of the composition on the surface of the substrate including the portion where the water- and oil-repellent coating layer is deposited; forming the water- and oil-repellent coating layer on the deposited primer layer; and purging the substrate on which the water- and oil-repellent coating layer is formed. The method has excellent wear-resistance, salt water resistance, chemical resistance and cosmetics resistance. | 2016-06-30 |
20160185660 | COATED ARTICLE WITH LOW-E COATING HAVING LOW VISIBLE TRANSMISSION - This invention relates to a coated article including a low-emissivity (low-E) coating. In certain example embodiments, the low-E coating is provided on a substrate (e.g., glass substrate) and includes at least first and second infrared (IR) reflecting layers (e.g., silver based layers) that are spaced apart by contact layers (e.g., NiCr based layers) and a dielectric layer of or including a material such as silicon nitride. In certain example embodiments, the coated article has a low visible transmission (e.g., no greater than 60%, more preferably no greater than about 55%, and most preferably no greater than about 50%). | 2016-06-30 |
20160185661 | Method of manufacturing optical fiber and apparatus of manufacturing the same - A method of manufacturing an optical fiber includes drawing an optical fiber preform and forming a bare optical fiber, disposing a coating layer formed of a resin on an outer circumference of the bare optical fiber, and curing the coating layer and obtaining an optical fiber. A direction of the bare optical fiber is changed by a direction changer in any position from drawing the optical fiber to disposing the coating layer, and the direction changer includes a guide groove which guides the bare optical fiber, | 2016-06-30 |
20160185662 | METHODS AND COMPOSITIONS FOR CONCRETE PRODUCTION - The invention provides compositions and methods directed to carbonation of a cement mix during mixing. The carbonation may be controlled by one or more feedback mechanisms to adjust carbon dioxide delivery based on one or more characteristics of the mix or other aspects of the mixing operation. | 2016-06-30 |
20160185663 | AMPHOTERIC BETAINE-TYPE POLYCARBOXYLATE SUPERPLASTICIZER AND PREPARATION METHOD THEREOF - An amphoteric betaine-type polycarboxylic acid water reducer and a preparation method therefor are provided in the present invention. An unsaturated betaine-type monomer A and an acrylic acid-type polyethylene glycol monomer B are placed in a reaction container, stirred until uniform and then an acrylic acid-type monomer C is added, the stirring is continued and water is added to make adjustments so as to make the total mass of the monomers account for 10%-20% of the total mass of the aqueous solution; and under the protection of an inert gas, the temperature is raised to 60° C.-100° C., an aqueous initiator solution is added, maintaining the temperature and reacting for 4-6 h, and after the reaction is completed, the solution is cooled to room temperature, and the pH value thereof is adjusted to 5-7 to prepare the amphoteric betaine-type polycarboxylic acid water reducer. | 2016-06-30 |
20160185664 | WIDE TEMPERATURE RANGE CEMENT RETARDER - According to an embodiment, a composition that can be used in a cementing. The composition includes at least:
| 2016-06-30 |
20160185665 | CRUMB-RUBBER AUGMENTED MASONRY BLOCKS - Crumb Rubber augmented masonry blocks including cement, aggregate, water, and crumb rubber. Crumb rubber is extracted from scrape tires after being processed and then mixed in specified percentages with aggregate, cement and water. In the present disclosure sand, which is used in the formation of conventional blocks, is replaced with crumb rubber to produce a sand-free masonry block containing crumb rubber. The developed crumb rubber masonry blocks satisfied the ASTM non-load bearing requirements in addition to satisfying the water absorption test. | 2016-06-30 |
20160185666 | PRODUCT HAVING A HIGH ALUMINA CONTENT - A sintered refractory product having the form of a block and consisting—of a granulate formed by all the grains having a size larger than 100 μm, referred to as “coarse grains”, and—a matrix binding said coarse grains and consisting of the grains having a size smaller than or equal to 100 μm, the granulate representing between 45% and 90% by mass of the product, said product having a composition such that, in a mass percentage based on the oxides: —Al2O3>80%, —SiO2<15%, —Na2O<0.15% —Fe2O3<0.05%, —CaO<0.1%,—the other oxides forming the remainder up to 100%, the Na2O content in the matrix being greater than 0.010%, in a mass percentage based on the mass of the product. | 2016-06-30 |
20160185667 | METHOD OF MANUFACTURING ALUMINA-BASED MILLING MEDIUM - The invention provides a cost effective and environmentally friendly process of manufacturing alumina-based, impact-resistant and wear-resistant ceramic objects from alumina of a lower purity. Particularly, the objects may serve as milling and grinding media, or as superior materials for ballistic and armor protection. | 2016-06-30 |
20160185668 | MULLITE SINTERED BODY, METHOD FOR PRODUCING THE SAME, AND COMPOSITE SUBSTRATE - A mullite sintered body according to the present invention has an impurity element content of 1% by mass or less and contains sintered mullite grains having an average grain size of 8 μm or less. When a surface of the mullite sintered body is finished by polishing, pores in the surface have an average largest pore length of 0.4 μm or less. The surface preferably has a center line average surface roughness (Ra) of 3 nm or less. The surface preferably has a maximum peak height (Rp) of 30 nm or less. The number of pores in the surface is preferably 10 or less per unit area of 4 μm×4 μm. | 2016-06-30 |
20160185669 | WAVE-ABSORBING MATERIALS AND METHODS FOR PREPARING THE SAME - Embodiments of the present disclosure are drawn to a wave-absorbing material that includes a main composition, an auxiliary composition, and a sintering additive. The main composition includes at least one of Fe | 2016-06-30 |
20160185670 | TITANIUM COMPOUND-CONTAINING SINTERED BODY - A titanium compound-containing core-shell powder includes a plurality of core-shell particles, each of which includes a core body and a shell layer encapsulating said core body. The core body is electrically conductive. The shell layer includes a crystal that is selected from titanate oxides having a perovskite structure and titanate oxides having a spinel structure. The core body and the shell layer are chemically bonded to each other. | 2016-06-30 |
20160185671 | METAL DETECTIBLE CERAMIC MATERIAL AND METHOD FOR MAKING THE SAME - A method for producing a cermet composition, including mixing a first predetermined amount of a yttria stabilized zirconia powder with between 2 and 8 weight percent mu-metal powder to define a homogeneous admixture, oxidizing the mu-metal in the admixture, forming the homogeneous admixture into a green body, calcining the green body in a first reducing atmosphere to remove oxygen from the oxidized mu-metal to yield a calcined body, and sintering the calcined body in a second reducing atmosphere to yield a densified body having no more than 0.8% porosity. The densified body has a plurality of mu-metal particles distributed therethrough, a hardness of at least 1450 HV, flexural strength of at least 200 kPSI, and a relative permeability μ/μ | 2016-06-30 |
20160185672 | HIGH TEMPERATURE RESISTANT SILICON JOINT FOR THE JOINING OF CERAMICS - A method for the joining of ceramic pieces with a hermetically sealed joint comprising brazing a layer of joining material between the two pieces. The ceramic pieces may be aluminum nitride or other ceramics, and the pieces may be brazed with a high purity silicon or a silicon alloy under controlled atmosphere. The joint material is adapted to later withstand both the environments within a process chamber during substrate processing, and the oxygenated atmosphere which may be seen within the interior of a heater or electrostatic chuck. | 2016-06-30 |
20160185673 | METHOD AND COMPOSITION FOR AGRICULTURAL POTASSIUM-PLUS FERTIGATION - An agricultural potassium-fertigation method for emitter-irrigation potassium-plus fertigation feeds a potassium-plus nutrient feedstock comprised of potassium formate and additional yield-assist constituent(s) and water to an active emitter-irrigation system discontinuously, at levels of 0.15 to 50 gal./min, during one to six nonconsecutive irrigation days during a crop cycle. | 2016-06-30 |
20160185674 | Method for Drying Spent Filter Media - Disclosed is a process of stabilizing spent filter material that comprises mixing the filter media with a dry media to produce a composition having a moisture content that is sufficiently low to retard microbial growth. The composition comprises spent filter media and a dry material, and preferably comprises diatomaceous earth. Soil is treated by adding the composition as a top dressing, soil amendment, or the like. | 2016-06-30 |
20160185675 | NOVEL LIGNIN MATERIALS CONTAINING COMPOSITIONS - The present invention primarily relates to a preparation comprising or consisting of 40-99.9 wt.-% of lignin, preferably unmodified lignin, 0.1-50 wt.-% of minerals, preferably 0.1-30 wt.-%, 0-25 wt.-% of one or more mono- and oligomeric carbohydrates, preferably 0.1-20 wt.-%, and 0-15 wt.-% of one or more solvents, in particular water, preferably 0.1-4 wt.-%. Furthermore, the present invention relates to a fertilizer comprising or consisting of such a preparation and to the use of such a preparation as fertilizer, as ingredient for a fertilizer or for producing a fertilizer. | 2016-06-30 |
20160185676 | METHOD FOR CULTIVATING CROPS USING BACTERIUM BELONGING TO GENUS BACILLUS - The present application provides: a microbial material for agricultural use characterized by containing, as an active ingredient, | 2016-06-30 |
20160185677 | CompRocks Compost Boulders - CompRocks Composting Boulders are units for composting organic materials which bottomless and rest like rocks and boulders in a landscape or garden. One or more units can be used for the natural creation of compost over a period of a year, depending upon the climate. Compost can be created directly at the site where it is needed simply by moving each unit and mulching the compost into the soil below it. Each unit consists of a hollow body with a lid opening for inputting organic matter and holes for aeration and moisture collection. The smallest units are simply filled annually and staked into the ground next to a particular planting so do not have input lids. | 2016-06-30 |
20160185678 | POLYMER-BORIC ACID COMPOSITIONS - Aqueous liquid formulations contain one or more anionic polymers, a high concentration of boron compounds, and a boron dispersant or solvent. The compositions are operable to maintain the boron content thereof in stable dispersion for at least 72 hours. The dispersant or solvent is selected from saturated aliphatic diols, glycols, hydroxyl-rich compounds, alpha-hydroxy acids, and mixtures thereof. Preferred polymers include dicarboxylic repeat units and optional sulfonate repeat units. The formulations have heretofore unattainable high boron contents, and are useful in agricultural contexts. | 2016-06-30 |
20160185679 | NOVEL FERTILIZER - The present invention is directed to a fertilizer composition comprising a cannabidiol (CBD Oil), and/or a tetrahydrocannabinol (THC Oil) and/or hemp oil derivatives in combination with a superabsorbent polymer(s) (SAP's). The present invention also relates to methods of using and manufacturing said fertilizers. | 2016-06-30 |
20160185680 | STABLE INSECTICIDAL PREMIXTURE FORMULATIONS - The present invention generally relates to agricultural formulations comprising at least one insecticide selected from the group consisting of pyrethroids and neonicotinoids, and at least one polymeric dispersant selected from the group consisting of anionic polyacrylate carboxylate copolymers, anionic styrene acrylic acid copolymers, and polyvinyl pyrrolidone copolymers. | 2016-06-30 |
20160185681 | Dual Purpose Agricultural Compositions - A method of fertilizing a plant comprises applying to a plant an effective amount of a composition comprising a product of a salicylic acid, a potassium polyphosphite, a potassium phosphite, and a potassium phosphate. The composition may be prepared by reacting salicylic acid, ammonium hydroxide, potassium hydroxide and/or potassium carbonate, phosphoric acid, and phosphorous acid. | 2016-06-30 |
20160185682 | NITRIFICATION INHIBITOR COMPOSITIONS AND METHODS FOR PREPARING THE SAME - The present disclosure relates to enhanced nitrification inhibitor dry fertilizer compositions, methods for making the same, and their use in agricultural applications. | 2016-06-30 |
20160185683 | PROCESS OF ASYMMETRIC HYDROGENATION OF KETALS AND ACETALS - The present invention relates to a process of the asymmetric hydrogenation of a ketal of an unsaturated ketone or an acetal of an unsaturated aldehyde by molecular hydrogen in the presence of at least one chiral iridium complex. This process yields chiral compounds in a very efficient way and is very advantageous in that the amount of iridium complex can be remarkably reduced. | 2016-06-30 |
20160185684 | SELECTIVE OLEFIN METATHESIS WITH CYCLOMETALATED RUTHENIUM COMPLEXES - This invention relates generally to C—H activated ruthenium olefin metathesis catalyst compounds which are stereogenic at the ruthenium center, to their preparation, and the use of such catalysts in the metathesis of olefins and olefin compounds. In particular, the invention relates to the use of C—H activated ruthenium olefin metathesis catalyst compounds in Z-selective olefin metathesis reactions, enantio-selective olefin metathesis reactions, and enantio-Z-selective olefin metathesis reactions. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry. | 2016-06-30 |
20160185685 | BISPHOSPHITES HAVING A CENTRAL 2,3'-BIPHENOL UNIT - Bisphosphites having a central 2,3′-biphenol unit are useful for catalyzing hydroformylation. | 2016-06-30 |
20160185686 | Apparatus for the Production of Xylenes - In a process for producing para-xylene, a feed stream comprising C | 2016-06-30 |
20160185687 | Highly Selective Catalyst and Method of Isomerization of C4 - C7 Paraffin Hydrocarbons - The invention relates to isomerization catalysts and can be used in the petroleum processing and petrochemical industry. The catalyst contains sulfated zirconium oxide and a binder—aluminum oxide in a ratio of ZrO2/SO4 to Al2O3 from 70 to 30 to 90 to 10, as well as promoter, a group II metal, Ca, in a quantity ranging from 0.01 to 1 wt % of the weight of the catalyst. The catalyst also contains platinum and/or palladium in a quantity ranging from 0.1 to 0.45 wt % of the metal. Isomerization of C4-C7 paraffinic hydrocarbons in the presence of hydrogen at a temperature of 110-200° C., a pressure of 1-5 MPa, a hydrogen:hydrocarbon ratio of 0.5-4, and a feedstock space velocity of 0.5-4 h | 2016-06-30 |
20160185688 | HYDROCARBON PROCESSING APPARATUSES AND PROCESSES FOR PRODUCING N-PENTANE AND ISOBUTANE - Hydrocarbon processing apparatuses and processes for producing n-pentane and isobutane are provided herein. In an embodiment, a process for producing n-pentane and isobutane includes providing a hydrocarbon feed stream that includes C4 and C5 hydrocarbons. A recycle stream that includes C4+ hydrocarbons and the hydrocarbon feed stream is combined to produce a combined feed stream. The combined feed stream is separated to produce an iC4 product stream, an nC5+ product stream, and an iC5/nC4 feed stream. The iC5/nC4 feed stream is simultaneously disproportionated and isomerized in an isomerization zone to produce an intermediate stream that includes C3-C6 hydrocarbons. The C3-C6 hydrocarbons in the intermediate stream are separated to produce a C3− stream and the recycle stream that includes C4+ hydrocarbons. | 2016-06-30 |
20160185689 | SYNTHESIS OF TERMINAL ALKENES FROM INTERNAL ALKENES AND ETHYLENE VIA OLEFIN METATHESIS - This invention relates generally to olefin metathesis, and more particularly relates to the synthesis of terminal alkenes from internal alkenes using a cross-metathesis reaction catalyzed by a selected olefin metathesis catalyst. In one embodiment of the invention, for example, a method is provided for synthesizing a terminal olefin, the method comprising contacting an olefinic substrate comprised of at least one internal olefin with ethylene, in the presence of a metathesis catalyst, wherein the catalyst is present in an amount that is less than about 1000 ppm relative to the olefinic substrate, and wherein the metathesis catalyst has the structure of formula (II) | 2016-06-30 |
20160185690 | 7-METHYL-3-METHYLENE-7-OCTENYL HALIDE, METHOD FOR PRODUCING THE SAME, AND METHOD FOR PRODUCING 7-METHYL-3-METHYLENE-7-OCTENYL PROPIONATE - Provided is a simple, selective and efficient method for producing 7-methyl-3-methylene-7-octenyl propionate and the like. More specifically, provided is, for example, a method for producing 7-methyl-3-methylene-7-octenyl propionate, comprising the steps of: subjecting a nucleophile represented by Formula (1) and an electrophile represented by Formula (2) to a coupling reaction to obtain a 7-methyl-3-methylene-7-octenyl halide represented by Formula (3), and subjecting the 7-methyl-3-methylene-7-octenyl halide (3) to propionyloxylation to obtain the 7-methyl-3-methylene-7-octenyl propionate represented by Formula (4). | 2016-06-30 |
20160185691 | One-Component Reagent for the Fluoroalkylation Reaction - A composition, consisting essentially of copper, a fluoroalkyl group, and a ligand comprising at least one group-V donor. The molar ratio of copper to the fluoroalkyl group is approximately 1. | 2016-06-30 |
20160185692 | HIGH TEMPERATURE ISOMERIZATION OF (E)-1-CHLORO-3,3,3-TRIFLUOROPROPENE TO (Z)-1-CHLORO-3,3,3-TRIFLUOROPROPENE - Disclosed are processes for a high temperature isomerization reaction converting (E)-1-chloro-3,3,3-trifluoropropene to (Z)-1-chloro-3,3,3-trifluoropropene. In certain aspects of the invention, such a process includes contacting a feed stream with a heated surface, where the feed stream includes (E)-1-chloro-3,3,3-trifluoropropene or mixture of (E)-1-chloro-3,3,3-trifluoropropene with (Z)-1-chloro-3,3,3-trifluoropropene. The resulting product stream includes (Z)-1-chloro-3,3,3-trifluoropropene and (E)-1-chloro-3,3,3-trifluoropropene, where the ratio of (Z) isomer to (E) isomer in the product stream is higher than the ratio feed stream. The (E) and (Z) isomers in the product stream may be separated from one another. | 2016-06-30 |
20160185693 | PARTIALLY FLUORINATED COMPOUNDS - Described herein is a composition comprising a partially fluorinated compound selected from the group consisting of: (a) I(CF | 2016-06-30 |
20160185694 | ALCOHOL PRODUCTION METHOD - An alcohol production method whereby high quality alcohol can be easily and effectively produced includes a step in which an alcohol solution, which contains sugar and/or sugar alcohol as an impurity and an alcohol other than sugar alcohol as a main component, has the sugar and/or sugar alcohol adsorptively removed therefrom by contacting the alcohol solution with one type or a mixture of two or more types of adsorbents selected from zeolite, an ion-exchange resin, silica alumina, and alumina. | 2016-06-30 |
20160185695 | METHOD FOR THE PREPARATION OF PHENOLS - The present invention relates to a method for the preparation of phenols, in which an aryldiazonium salt, which is prepared by the diazotisation of a corresponding aromatic, primary amine, is decomposed by heating in a mixture containing hot water, a mineral acid and an organic solvent, wherein the organic solvent contains a ketone of formula (I) R | 2016-06-30 |
20160185696 | Method for Obtaining Bisphenol-A (BPA) from Polycarbonate Waste Using Microwave Radiation - The invention consists of a method for obtaining bisphenol-A (BPA) from decomposing polycarbonate waste prepared with bisphenol-A (BPA), which incorporates microwave technology for reaction heating. This method consists of preparing an alkaline solution in alcohol composed of metallic hydroxide in an alcohol, where the hydroxide may be of sodium or potassium, and alcohol is methanol. The solution is mixed with bisphenol-A (BPA) polycarbonate waste and put on a reactor with agitation inside a device provided with a microwave radiation generator for chemical reactions, maintaining a temperature ranging between 90° C. and 150° C., for a period from 3 min to 10 min, preferably between 5 and 7 min, to decompose the polycarbonate and obtain bisphenol-A (BPA). | 2016-06-30 |
20160185697 | METHOD FOR PREPARING ISOPRENOL-ALKOXYLATE COMPOSITIONS HAVING A LOW ISOPRENE-CONTENT - The present invention relates to methods for preparing a composition comprising an isoprenol-alkoxylate having an isoprene-content of not more than 1000 ppm. The present invention also relates to compositions prepared or obtainable by such methods. The present invention further relates to the use of peroxides for decreasing the isoprene-content in a composition. | 2016-06-30 |
20160185698 | Methods for Preparing Methacrolein from t-Butanol - A method for preparing methacrolein from t-butanol, specifically a method for preparing methacrolein by using t-butanol as a starting material, is disclosed, comprising passing the starting material through a fixed bed reactor filled with catalyst, wherein the fixed bed reactor is divided to n reaction zones from the inlet of the starting material to the outlet of the starting material and each zone is filled with catalysts of different catalytic activities; wherein the catalytic activity of the catalyst in the first reaction zone is higher than the catalytic activity of the catalyst in the second reaction zone, and the catalytic activity of the catalyst is gradually increased from the second reaction zone to the last reaction zone; and n is an integer between 3 to 10. | 2016-06-30 |
20160185699 | METHOD OF ACYLATING AN AROMATIC COMPOUND - The present invention relates to a method of acylating a substituted aromatic compound. The substituted aromatic compound is reacted with an acylating agent in the presence of a macroreticular sulfonic acid ion exchange resin having a water-to-phenol shrinkage between 25% and 40%. The method is very advantageous in that the resin is deactivated much less than other resins without a fast drop in conversion and selectivity in the reaction. | 2016-06-30 |
20160185700 | METHYL-IODIDE-FREE CARBONYLATION OF AN ALCOHOL TO ITS HOMOLOGOUS ALDEHYDE AND/OR ALCOHOL - Disclosed is a process for the reductive carbonylation of a low molecular weight alcohol to produce the homologous aldehyde and/or alcohol. The process includes conducting the reaction to produce the aldehyde in the presence of a single component catalyst complex composed of cobalt, an onium cation and iodide in a ratio of 1:2:4 without additional promoters. A ruthenium co-catalyst is used in the production of the homologous alcohol. The reductive carbonylation reaction does not require an additional iodide promoter and produces a crude reductive carbonylation product substantially free of methyl iodide. | 2016-06-30 |
20160185701 | METHYL-IODIDE-FREE CARBONYLATION OF AN ALCOHOL TO ITS HOMOLOGOUS ALDEHYDE AND/OR ALCOHOL - Disclosed is a process for the reductive carbonylation of a low molecular weight alcohol to produce the homologous aldehyde and/or alcohol. The process includes conducting the reaction to produce the aldehyde in the presence of a catalyst complex composed of cobalt, an onium cation and iodide in a ratio of 1:2:4 with a phosphine ligand. A ruthenium co-catalyst is used in the production of the homologous alcohol. The reductive carbonylation reaction does not require an additional iodide promoter and produces a crude reductive carbonylation product substantially free of methyl iodide. | 2016-06-30 |
20160185702 | USING MIXTURES OF E/Z ISOMERS TO OBTAIN QUANTITATIVELY SPECIFIC PRODUCTS BY COMBINING ASYMMETRIC HYDROGENATION AND ISOMERIZATION - The present invention relates to a process of manufacturing compound having stereogenic centres from a mixture of E/Z isomers of unsaturated compounds having prochiral double bonds. The hydrogenation product has a specific desired configuration at the stereogenic centres. The process involves an asymmetric hydrogenation and an isomerization step. The process is very advantageous in that it forms the desired chiral product from a mixture of stereoisomers of the starting product in an efficient way. | 2016-06-30 |
20160185703 | COMPOUNDS FROM ANTRODIA CAMPHORATA, METHOD FOR PREPARING THE SAME AND USE THEREOF - The invention relates to bioactive compounds purified from mycelium of | 2016-06-30 |
20160185704 | LACTATE PRODUCTION PROCESS - A process for producing lactic acid is provided. The process comprises (a) reacting a stream rich in saccharide with sodium hydroxide in the presence of water to produce a reaction mixture comprising sodium lactate; (b) reacting at least a portion of the sodium lactate with HCl to produce lactic acid and sodium chloride; (c) converting at least a portion of the sodium chloride to chlorine and sodium hydroxide; and (d) recycling at least a portion of the sodium hydroxide produced in step (c) to step (a). Also provided are processes for the production of alkyl lactate, oligomeric lactic acid, lactide, alkyl lactyllactate, poly-lactic acid, propylene glycol and acrylic acid. | 2016-06-30 |
20160185705 | HYDROBROMINATION METHOD - A process for synthesizing a product of formula Br—(CH | 2016-06-30 |
20160185706 | SOLID, HETEROGENEOUS CATALYSTS AND METHODS OF USE - Solid mixed catalysts and methods for use in conversion of triglycerides and free fatty acids to biodiesel are described. A batch or continuous process may be used with the catalysts for transesterification of triglycerides with an alkyl alcohol to produce corresponding mono carboxylic acid esters and glycerol in high yields and purity. Similarly, alkyl and aryl carboxylic acids and free fatty acids are also converted to corresponding alkyl esters. The described catalysts are thermostable, long lasting, and highly active. | 2016-06-30 |
20160185707 | 3-ACYLOXYMETHYL-3-BUTENYL CARBOXYLATE COMPOUND AND METHOD FOR PRODUCING 4-ALKYL-3-METHYLENEBUTYL CARBOXYLATE - Provided is a simple, selective and efficient method for producing 4-alkyl-3-methylenebutyl carboxylates such as 7-methyl-3-methylene-7-octenyl propionate. More specifically provided is a method for producing a 4-alkyl-3-methylenebutyl carboxylate compound, the method comprising a diacyloxylation step of subjecting a 4-halo-2-halomethyl-1-butene compound (6) to diacyloxylation to obtain a 3-acyloxymethyl-3-butenyl carboxylate compound (3), and a coupling step of subjecting the 3-acyloxymethyl-3-butenyl carboxylate compound (3) to a coupling reaction with an organometallic reagent (4) to obtain the 4-alkyl-3-methylenebutyl carboxylate compound (5). | 2016-06-30 |
20160185708 | 1-(2-ACYLOXYETHYL)CYCLOPROPYL SULFONATE COMPOUND, 3-HALOMETHYL-3-BUTENYL CARBOXYLATE COMPOUND, AND METHOD FOR PRODUCING 4-ALKYL-3-METHYLENEBUTYL CARBOXYLATE - Provided is a simple, selective and efficient method for producing 4-alkyl-3-methylenebutyl carboxylates such as 7-methyl-3-methylene-7-octenyl propionate. More specifically, provided is, for example, a method for producing a 4-alkyl-3-methylenebutyl carboxylate compound, comprising an acyloxylation step of subjecting a 1-(2-haloethyl)cyclopropyl sulfonate compound (1) to acyloxylation to obtain a 1-(2-acyloxyethyl)cyclopropyl sulfonate compound (2), a halogenation step of subjecting the compound (2) to halogenation involving cyclopropyl-allyl rearrangement to obtain a 3-halomethyl-3-butenyl carboxylate compound (3), and a coupling step of subjecting the compound (3) to a coupling reaction with an organometallic reagent (4) to obtain the 4-alkyl-3-methylenebutyl carboxylate compound (5). | 2016-06-30 |
20160185709 | METHOD OF MAKING A TEMPLATING AGENT - A method for preparing 1-adamantyltrimethylammonium methylcarbonate or N,N-dimethyl-3,5-dimethylpiperidinium methylcarbonate is disclosed. The method comprises reacting dimethyl carbonate and 3,5-dimethylpiperidine or a 1-adamantylamine compound and in the presence of water in a sealed vessel at a temperature of from 80 to 200° C. The 1-adamantylamine compound is 1-adamantylamine, 1-adamantylmethylamine, or mixtures thereof. | 2016-06-30 |
20160185710 | BETA-SUBSTITUTED BETA-AMINO ACIDS AND ANALOGS AS CHEMOTHERAPEUTIC AGENTS - β-Substituted β-amino acids, β-substituted β-amino acid derivatives, and β-substituted β-amino acid analogs and (bio)isosteres and their use as chemotherapeutic agents are disclosed. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and (bio)isosteres are selective LAT1/4F2hc substrates and exhibit rapid uptake and retention in tumors expressing the LAT1/4F2hc transporter. Methods of synthesizing the β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and methods of using the compounds for treating cancer are also disclosed. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs exhibit selective uptake in tumor cells expressing the LAT1/4F2hc transporter and accumulate in cancerous cells when administered to a subject in vivo. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and (bio)isosteres exhibit cytotoxicity toward several tumor types. | 2016-06-30 |
20160185711 | Process and Device for Recycling Waste Acid Produced in Process of Producing Zoalene - A process and a device for recycling waste acid produced in the process of producing Zoalene. The process comprises steps: heating, depressurizing and distilling the waste acid recycled after nitration reaction; collecting acid liquid A and distilled water A; mixing the acid liquid A with new concentrated sulfuric acid in proportion, and putting the mixture to a new Zoalene nitration reaction process; and putting the distilled water A into a diluting pot for diluting the liquid produced in the nitration reaction. The waste acid produced in the process of producing Zoalene is recycled and not directly discharged; water resources are recycled, waste of the water resources is reduced, and discharge of waste water produced in the process of producing Zoalene is greatly reduced, so that not only production cost is saved, but also environment pressure is reduced. | 2016-06-30 |
20160185712 | PHOTO-ACTIVATED HYDROGELS - Presented herein are compositions and articles including a crosslinkable polymer that produces a crosslinked polymer upon exposure to light and/or heat. In some embodiments, the compositions are used to fill fine lines and wrinkles to provide a cosmetic benefit. In other embodiments, the compositions and articles have desirable release properties for embedded materials. | 2016-06-30 |
20160185713 | A Process to Produce Polycarbamate, Polycarbamate Produced Thereby and a Coating Composition Comprising the Polycarbamate - A process to prepare polycarbamate comprising adding urea to a polyol in the presence of at least one catalyst selected from the group consisting of compounds having the following formula M | 2016-06-30 |
20160185714 | CARBOXYLIC ACID ESTER/CARBAMATE COMPOUND WITH POLYMERIZABLE FUNCTIONAL GROUP AND FLUORINE ATOM GROUP, AND MANUFACTURING METHOD THEREFOR - Provided are a fluorine-containing monomer soluble in a hydrocarbon-based solvent as well as excellent in water and oil repellence, and a manufacturing method therefor. The fluorine-containing monomer is a carboxylic acid ester/carbamate compound having a polymerizable functional group and a fluorine atom group, and represented by the following general formula: C | 2016-06-30 |
20160185715 | Method for Enhancing the Rate of the Formation of the Reaction Product of a Carboxylic Acid and Urea via Acid Addition - The present invention is directed to a method for enhancing the rate of formation of the reaction products of a carboxylic acid and a urea having the formula: | 2016-06-30 |
20160185716 | SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS - Disclosed are selective histone deactylase inhibitors (HDACi) that having Formula I. Specifically, the disclosed subject matter relates to compounds having activity as selective HDAC6 inhibitors, methods of making and using the compounds, and compositions comprising the compounds. In still further aspects, the disclosed subject matter relates to methods for treating oncological disorders in a patient. Methods of making and using these inhibitors for the treatment of cancer, in particular melanoma are also disclosed. | 2016-06-30 |
20160185717 | COMPOUNDS WITH ANTIBACTERIAL ACTIVITY - The present invention relates to compounds of general formula (I) | 2016-06-30 |
20160185718 | Stabilized Multi-Functional Antioxidant Compounds and Methods of Use - Disclosed are novel stable compounds having anti-oxidant properties and methods of using the compounds for the treatment of diseases or injuries associated with oxidative stress. | 2016-06-30 |
20160185719 | FLUORINATED COMPOUNDS CONTAINING A -OSF5 GROUP AND PROCESS FOR THEIR PREPARATION - A process for the preparation of fluorinated compounds having at least one —OSF | 2016-06-30 |
20160185720 | Salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-p- henyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid - Novel salt forms of [R—(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid characterized by their X-ray powder diffraction pattern and solid-state NMR spectra are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia, and Alzheimer's Disease. | 2016-06-30 |
20160185721 | INDOLE-CARBOXAMIDES - The present invention relates to compounds of general formula | 2016-06-30 |
20160185722 | METHOD FOR PRODUCING META-XYLYLENEDIAMINES AND METHOD FOR PRODUCING BISAMIDE COMPOUND - A method for producing meta-xylylenediamines includes a reaction step in which monohalogenated benzenes, formaldehydes, and an amide compound having a primary amide group or a secondary amide group are allowed to react in the presence of an acidic liquid, a dehalogenation step in which the halogen atom derived from the monohalogenated benzenes is replaced with a hydrogen atom, and a deprotection step in which the primary amide group or the secondary amide group derived from the amide compound is converted to an amino group. In the reaction step, the acidic liquid contains inorganic acid, the equivalent ratio of the hydrogen atom of the inorganic acid relative to the monohalogenated benzenes is more than 16; the acidic liquid has an inorganic acid concentration of more than 80 mass %; and the reaction temperature is more than 40° C. | 2016-06-30 |
20160185723 | C-H FLUORINATION OF HETEROCYCLES WITH SILVER (II) FLUORIDE - The present invention provides compositions and methods for the selective C—H fluorination of nitrogen-containing heteroarenes with AgF | 2016-06-30 |
20160185724 | HYDROXYPHENYL DERIVATIVES AND BIOLOGICAL APPLICATIONS THEREOF - The invention relates to hydroxyphenyl derivatives of formula (I); and uses thereof as anti-bacterial and/or anti-parasitic agents. | 2016-06-30 |
20160185725 | c-Met Modulators and Method of Use - The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds. | 2016-06-30 |
20160185726 | ANTHELMINTIC COMPOUNDS AND COMPOSITIONS AND METHOD OF USING THEREOF - The present invention relates to novel anthelmintic compounds of formula (I) below: | 2016-06-30 |
20160185727 | SUBSTITUTED 4-AMINO-5-(CYCLOHEXYLOXY)QUINOLINE-3-CARBOXYLIC ACIDS AS SWEET FLAVOR MODIFIERS - Disclosed herein are 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acid compounds having useful as sweet flavor modifiers. Also disclosed herein are ingestible compositions that include one or more of these compounds in combination with a natural or artificial sweetener. | 2016-06-30 |
20160185728 | CYANOQUINOLINE DERIVATIVES - Disclosed is a compound of formula I, a stereoisomer thereof, a cis-trans-isomer thereof, a tautomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, a solvate thereof or a prodrug thereof, | 2016-06-30 |
20160185729 | PROCESSES FOR PREPARING 3-BENZAZEPINES - The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity. | 2016-06-30 |
20160185730 | DRUG FOR INHIBITING AGGREGATION OF PROTEINS INVOLVED IN DISEASES LINKED TO PROTEIN AGGREGATION AND/OR NEURODEGENERATIVE DISEASES - The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of diseases linked to protein aggregation and/or neurodegenerative diseases. Moreover, the present invention relates to pharmaceutical and diagnostic compositions comprising the compound of the invention as well as to a kit. Furthermore, the present invention relates to a method of imaging deposits of aggregated protein. A kit for preparing a detectably labelled compound of the present invention is also disclosed. | 2016-06-30 |
20160185731 | METHOD FOR PRODUCING 3,5-BIS(FLUOROALKYL)-PYRAZOL-4-CARBOXYLIC ACID DERIVATIVES AND 3,5-BIS(FLUOROALKYL)-PYRAZOLES - The present invention relates to novel 3,5-bis(fluoroalkyl)pyrazole-4-carboxylic acid derivatives and to a process for preparing 3,5-bis(fluoroalkyl)pyrazole-4-carboxylic acid derivatives and 3,5-bis(fluoroalkyl)pyrazoles. | 2016-06-30 |
20160185732 | METHOD AND INDUSTRIAL PROCESS FOR CONTINUOUS SYNTHESIS OF DIFFERENT IONIC LIQUIDS - Producing different ionic liquids industrially currently requires either operating separate plants or continually refitting existing plants. While this is not laborious, it is often not economical either. The problem the present invention addresses is that of describing a method and an industrial process by which different ionic liquids can be produced almost synchronously in a unitary production sequence. This is done either by using a chemical intermediate both relatively simple to prepare and readily convertible into multiple products, or by preparing the desired products in the same industrial process by direct synthesis from the appropriate starting materials. The method described here allows the synthesis of different ionic liquids in excellent yields and grades in a unitary production operation. | 2016-06-30 |
20160185733 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1 - The present invention relates to compounds of formula I: | 2016-06-30 |
20160185734 | METHOD FOR PRODUCING OPTICALLY ACTIVE 5-HYDROXY-3-KETOESTER - The object of the present invention is to provide a method for producing in high yield with high stereoselectivity an optically active 5-hydroxy-3-ketoester compound which is useful as an intermediate for a pharmaceutical. A novel method for producing an optically active 5-hydroxy-3-ketoester compound in which an asymmetric aldol reaction by use of 1,3-diene compound is carried out in the presence of an optically active binaphthol-titanium complex together with a substituted nitrogen-containing 5 or 6-membered aromatic heterocyclic compound to obtain an optically active 5-hydroxy-3-ketoester compound in high yield with high stereoselectivity; and a novel production intermediate having a crystalline form. | 2016-06-30 |
20160185735 | FATTY ACID ANALOGS AND THEIR USE - Embodiments of novel fatty acid analogs, precursors of such analogs, pharmaceutical compositions including same, and methods of their use are disclosed. In several embodiments, the disclosed fatty acid analogs can be used to detect and monitor β-oxidation in cells and tissue, for example, in methods of detecting a tumor, such as a prostate tumor. | 2016-06-30 |
20160185736 | NOVEL, TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME - The present invention provides a novel P2X | 2016-06-30 |
20160185737 | N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS - The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter. | 2016-06-30 |
20160185738 | PROCESS FOR PRODUCING 2-PHENYL-1,3-BENZOXAZOLES - The present invention relates to a novel method for producing 2-phenyl-1,3-benzoxazoles of formula (I). | 2016-06-30 |
20160185739 | Solid Forms Of A Transthyretin Dissociation Inhibitor - The present invention relates to solid forms of the N-methyl-D-glucamine (meglumine) salt of 6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole and to methods for their preparation. The invention is also directed to pharmaceutical compositions containing at least one solid form and to the therapeutic or prophylactic use of such solid forms and compositions. | 2016-06-30 |
20160185740 | 2-BENZOYLAMINOBENZAMIDE DERIVATIVES AS BCL-3 INHIBITORS - The invention relates to a compound of general formula (I): | 2016-06-30 |
20160185741 | PROCESS FOR THE PREPARATION OF PROPYLENE OXIDE - A continuous process for the preparation of propylene oxide, comprising (i) providing a liquid feed stream comprising propene, hydrogen peroxide, acetonitrile, water, dissolved potassium dihydrogen phosphate, and optionally propane; (ii) passing the liquid feed stream provided in (i) into an epoxidation reactor comprising a catalyst comprising a titanium zeolite of structure type MWW, and subjecting the liquid feed stream to epoxidation reaction conditions; (iii) removing an effluent stream from the epoxidation reactor; wherein the concentration of the dissolved potassium dihydrogen phosphate in the liquid feed stream is at least 10% of the solubility limit of the potassium dihydrogen phosphate in the liquid feed stream. | 2016-06-30 |
20160185742 | Method for Preparing Benzopyran Compound and Application thereof in Treating Pulmonary Fibrosis - The present invention opens to the public a method to prepare a benzopyran compound and its use for treating pulmonary fibrosis. A benzopyran compound has a structure (I): | 2016-06-30 |
20160185743 | 15-Oxospiramilactone Derivatives, Preparation Method and Uses Thereof - The invention relates to a derivative of 15-oxospiramilacton, particularly to a compound of Formula I or II, or an isomer, a solvate or a pharmaceutically acceptable salt thereof. The invention also relates to a pharmaceutical composition comprising the compound as pharmaceutically active ingredient, a method for preparing the same, and use thereof in manufacture of an anti-tumor agent. The derivative of 15-oxospiramilactone of the invention have an activity against multiple tumor cell lines, and the anti-tumor activity is positively correlated to an activity inhibiting the Wnt signaling pathway. | 2016-06-30 |
20160185744 | COMPOUND FOR INHIBITING SYK ACTIVITY - A compound of formula (I) or a pharmaceutically acceptable salt, hydrate or prodrug thereof for inhibiting Syk activity, | 2016-06-30 |
20160185745 | ANALOGS OF VINAXANTHONE AND XANTHOFULVIN, METHODS OF SYNTHESIS, AND METHODS OF TREATMENTS THEREOF - The present invention relates generally to methods of synthesis of vinaxanthone and xanthofulvin, novel analogs, and methods of use thereof. | 2016-06-30 |
20160185746 | DIOXOLANE DERIVATIVE, LIQUID CRYSTAL COMPOSITION, LIQUID CRYSTAL ELEMENT, AND LIQUID CRYSTAL DISPLAY DEVICE - A dioxolane derivative represented by formula (G1) is provided. The explanation of the substituents is given in the specification. The use of the dioxolane derivative enables the production of a liquid crystal composition and a liquid crystal display device including the liquid crystal composition. | 2016-06-30 |
20160185747 | N-CYCLOALKYL-N-[(FUSEDPHENYL)METHYLENE]-(THIO)CARBOXAMIDE DERIVATIVES - The present invention relates to fungicidal N-cycloalkyl-N-[(fusedphenyl)methylene] carboxamide derivatives and their thiocarbonyl derivatives, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions. | 2016-06-30 |
20160185748 | PYRIDYL REVERSE SULFONAMIDES FOR HBV TREATMENT - The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention. | 2016-06-30 |
20160185749 | METHOD FOR THE SYNTHESIS OF 4-(HETEROCYCLOALKYL)-BENZENE-1,3,-DIOL COMPOUNDS - A method is described for the synthesis of 4-(heterocycloalkyl)-benzene-1,3-diol compounds of general formulae (I) and (II): | 2016-06-30 |
20160185750 | NICOTINE SALTS, CO-CRYSTALS, AND SALT CO-CRYSTAL COMPLEXES - The invention provides certain nicotine salts, co-crystals, and salt co-crystals and provides novel polymorphic forms of certain nicotine salts. In particular, nicotine salts with orotic acid are described. The invention further provides methods of preparation and characterization of such nicotine salts. In addition, tobacco products, including smoking articles, smokeless tobacco products, and electronic smoking articles comprising nicotine salts, co-crystals, and/or salt co-crystals are also provided. | 2016-06-30 |
20160185751 | METHOD FOR PREPARING BENZAMIDE DERIVATIVE, NOVEL INTERMEDIATE USED IN PREPARATION OF BENZAMIDE, AND METHOD FOR PREPARING NOVEL INTERMEDIATE - The present invention relates to a method for preparing N-[[1-{3-(1,2,3-triazol-1-yl)propyl}piperidin-4-yl]methyl]-4-amino-5-chloro-2-methoxybenzamide, which is a novel benzamide derivative as a 5-HT4 receptor agonist, or a pharmaceutically acceptable salt thereof; to a novel intermediate capable of being used in the preparation of the compounds; and to a method for preparing the same. The preparation methods of the present invention can be useful for mass production since a low-priced reagent and intermediate are used and the number of reaction processes is decreased, thereby saving preparation costs and improving the yield. | 2016-06-30 |
20160185752 | PIPERIDINE AND AZEPINE DERIVATIVES AS PROKINETICIN RECEPTOR MODULATORS - The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof (Formula (I)) in which m, X, R | 2016-06-30 |
20160185753 | DEUTERATED DIAMINOPYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS - Deuterated diaminopyrimidine compounds and pharmaceutical compositions containing such compounds are described. In particular, disclosed are deuterated diaminopyrimidine compounds of formula (I), and pharmaceutical compositions containing such compounds or crystal forms, pharmaceutically acceptable salt, hydrates or solvates thereof. The disclosed deuterated diaminopyrimidine compounds can be used for treating and/or preventing protein kinase-associated diseases, such as cell proliferative disease, cancer, immune disease and the like. | 2016-06-30 |
20160185754 | Chemical Process for the Synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)qu- inazoline - The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline. | 2016-06-30 |