27th week of 2014 patent applcation highlights part 58 |
Patent application number | Title | Published |
20140187744 | Bilirubin Excretion Enhancer - The purpose of the present invention is to establish a novel therapy method for hyperbilirubinemia and therefore, to provide a bilirubin excretion enhancer. The present invention provides a bilirubin excretion enhancer comprising, as an active ingredient, a serum albumin domain II-like protein comprising a serum albumin subdomain IIA. In one embodiment, the serum albumin subdomain IIA has an amino acid sequence of SEQ ID NO: 1. In one embodiment, the serum albumin domain II-like protein is a serum albumin domain II. In one embodiment, the serum albumin domain II comprises the amino add sequence of SEQ ID NO: 4. | 2014-07-03 |
20140187745 | METHOD FOR PREPARING BIVALIRUDIN - A method for preparing bivalirudin. The method includes preparing a bivalirudin resin by a solid phase synthesis, performing acidolysis of the bivalirudin resin to obtain crude bivalirudin, and purifying the crude bivalirudin to obtain purified bivalirudin. The solid phase synthesis method includes successively coupling Fmoc-protected amino acids corresponding to a sequence represented by SEQ. ID NO. 2 on an Fmoc-Leu-carrier resin through solid phase coupling synthesis to obtain the bivalirudin resin represented by SEQ. ID NO. 2. | 2014-07-03 |
20140187746 | PRECIPATABLE PEPTIDES - The invention is directed to a Ca2+ precipatable polypeptide tags and cassettes useful for purification of molecules from heterogeneous samples. The invention also relates to methods for bioseparation of molecules comprising Ca2+ precipatable tags and cassettes. | 2014-07-03 |
20140187747 | Discordant Helix Stabilization For Prevention of Amyloid Formation - The invention is based on the discovery that the presence of a discordant helix in a protein or peptide is predictive of that protein or peptide's ability to form amyloid. The invention includes methods for detecting discordant helices and methods of screening for compounds that stabilize the α-helix of a discordant helix-containing polypeptide. Compounds discovered using these methods are useful for treating or preventing disorders in which amyloid is produced. Such disorders include Alzheimer's disease and prion-associated disorders. | 2014-07-03 |
20140187748 | MIRAC PROTEINS - This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly inactivated at the wild type normal physiological conditions. For example, evolved proteins are virtually inactive at body temperature, but are active at lower temperatures. | 2014-07-03 |
20140187749 | SINGLE UNIT CHROMATOGRAPHY ANTIBODY PURIFICATION - The present invention relates to a method for the purification of antibodies from a protein mixture produced in a bioreactor, at least comprising the steps of intermediate purification and polishing, wherein the intermediate and polishing step comprises in-line anion exchange chromatography (AEX) treatment and mixed mode chromatography (MiMo) treatment in flow through mode. The present invention further relates to a single operational unit comprising both an anion exchange chromatography part and a mixed mode chromatography part, which are serially connected, wherein the unit comprises an inlet at the upstream end of the anion exchange chromatography part and an outlet at the downstream end of the mixed mode chromatography part and wherein the unit also comprises an inlet between the anion exchange chromatography part and the mixed mode chromatography part. | 2014-07-03 |
20140187750 | METHODS FOR SELECTING PROTEASE RESISTANT POLYPEPTIDES - The disclosure relates to a method for selecting, isolating and/or recovering a peptide or polypeptide from a library or a repertoire of peptides and polypeptides (e.g., a display system) that is resistant to degradation by a protease such as a protease found in the serum. Generally, the method comprises providing a library or repertoire of peptides or polypeptides, incubating the library or repertoire with a protease under conditions suitable for protease activity, and selecting, isolating and/or recovering a peptide or polypeptide that is resistant to degradation by the protease and has a desired biological activity. The selected peptides and polypeptides have utility as therapeutics, e.g., for treating disease in humans. | 2014-07-03 |
20140187751 | PURIFICATION OF FUSION PROTEINS - The invention relates generally to methods for purifying a Fc-fusion protein produced in a eukaryotic expression system. More specifically, the invention provides a robust and scalable downstream purification process suitable for use in manufacturing TNFR:Fc for human administration which comprises an optimized Protein A affinity chromatography step and two ion exchange chromatography steps both of which are operated in the bind-and-elute mode. | 2014-07-03 |
20140187752 | ANTIGENIC COMPOSITIONS AND USE OF SAME IN THE TARGETED DELIVERY OF NUCLEIC ACIDS - Methods and compositions are provided for delivery of therapeutic nucleic acids to a target cell. A chimeric antigen is provided to encapsulate, bind, or otherwise carry a nucleic acid molecule to a target cell where the chimeric antigen and nucleic acid are internalized, for example by receptor-mediated endocytosis. The chimeric antigen has a nucleic acid interaction domain, a target binding domain, and an immune response domain that may include a target antigen. Targeting is generally provided by the specificity of the target binding domain for a particular target cell receptor, but may also be provided by inclusion of a targeting antigen within the immune response domain. The combined delivery of chimeric antigen and nucleic acid, which may be a siRNA, may be synergistic in certain applications, for example in breaking host tolerance to a virus or in providing immunostimulation. | 2014-07-03 |
20140187753 | Hetero-Dimeric Immunoglobulins - The present invention relates to engineered hetero-dimeric immunoglobulins or fragments thereof and methods of making the same. | 2014-07-03 |
20140187754 | ANTI-FGFR3 ANTIBODIES AND METHODS USING SAME - The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies. | 2014-07-03 |
20140187755 | CLOSTRIDIAL NEUROTOXINS WITH ALTERED PERSISTENCY - The invention relates to a polypeptide comprising:
| 2014-07-03 |
20140187756 | Methods of preparing antibody-active agent conjugates - The invention provides methods for preparing an antibody-active agent conjugate. The conjugate comprises an antibody, a cysteine residue of an amino acid motif that can be recognized by an isoprenoid transferase located at or after the carboxy-terminus of the antibody, an isoprenoid unit operably linked to the cysteine residue, and an active agent. The invention also provides a composition comprising the antibody-active agent conjugate prepared by the methods. | 2014-07-03 |
20140187757 | METHODS AND COMPOSITIONS - The invention relates to a complex comprising a phage particle, said phage particle comprising
| 2014-07-03 |
20140187758 | Methods For Purifying Insect Membrane-Bound Receptor Proteins From Recombinant Production Hosts - The invention is drawn to a method for purifying membrane-bound proteins expressed in recombinant insect cells using N-laurosarcosine. The invention is particularly suited for expressing cadherin-type receptors cloned from | 2014-07-03 |
20140187759 | BIOREFINING PROCESSES AND APPARATUS FOR SEPARATING CELLULOSE HEMICELLULOSE, AND LIGNIN FROM BIOMASS - The disclosed invention is a modification of the AVAP® technology, employing CO | 2014-07-03 |
20140187760 | Lignin Precipitation Methods - A method of separating lignin from black liquor from a pulp mill by adjusting the pH of the black liquor is provided. Various additional steps can be used to further process the separated lignin, including washing, drying, and/or comminuting. In certain embodiments, solvents and byproducts are recycled so as to reduce waste and maintain chemical balance within a commercial lignin production facility. | 2014-07-03 |
20140187761 | NEW STEVIOL GLYCOSIDE | 2014-07-03 |
20140187762 | Optical Sorting Method - The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having the desired activity using a change in the optical properties of the genetic elements. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention. | 2014-07-03 |
20140187763 | DARK QUENCHERS FOR DONOR-ACCEPTOR ENERGY TRANSFER - The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes. | 2014-07-03 |
20140187764 | GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA - We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas. | 2014-07-03 |
20140187765 | NEAR FULL-GENOME ASSAY OF HCV DRUG RESISTANCE - Assays for characterization of genotypic mutations of Hepatitis C Virus (HCV) showing a resistance to anti-HCV drugs. | 2014-07-03 |
20140187766 | PREPARATION OF POLY ALPHA-1,3-GLUCAN ESTERS AND FILMS THEREFROM - Poly alpha-1,3-glucan ester compounds are disclosed herein with a degree of substitution of about 0.05 to about 3.0. Also disclosed are methods of producing poly alpha-1,3-glucan ester compounds and films made therefrom. | 2014-07-03 |
20140187767 | PREPARATION OF POLY ALPHA-1,3-GLUCAN ESTERS AND FILMS MADE THEREFROM - Poly alpha-1,3-glucan ester compounds are disclosed herein with a degree of substitution of about 0.05 to about 3.0. Also disclosed are methods of producing poly alpha-1,3-glucan ester compounds and films made therefrom. | 2014-07-03 |
20140187768 | CHLORINATION OF CARBOHYDRATES AND CARBOHYDRATE DERIVATIVES - Disclosed is a method for chlorinating a carbohydrate or a derivative thereof to produce a polychlorinated carbohydrate or a derivative thereof, such as sucralose, the method involves (i) reacting the carbohydrate or derivative thereof with a chlorinating agent to obtain a reaction mixture comprising said polychlorinated carbohydrate or derivative thereof and at least one under-chlorinated carbohydrate or derivative thereof, (ii) returning the at least one under-chlorinated carbohydrate or derivative thereof to a chlorinating step and further chlorinating the at least one under-chlorinated carbohydrate or derivative thereof to obtain the desired polychlorinated carbohydrate or derivative thereof; and (iii) optionally repeating steps (i) and (ii) “n” times where n≧1. The polychlorinated carbohydrate or a derivative thereof is obtained in high yields. | 2014-07-03 |
20140187769 | Oxadiazoanthracene Compounds for the Treatment of Diabetes - The present invention provides methods of synthesizing oxadiazoanthracene derivatives of the formula (I) and pharmaceutically acceptable salts thereof, | 2014-07-03 |
20140187770 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS - The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators. | 2014-07-03 |
20140187771 | AMORPHOUS SOLID SALTS - The invention provides an amorphous solid of a compound of formula (I) or of a salt thereof as well as compositions comprising the amorphous solids, and methods for making and using the amorphous solids. | 2014-07-03 |
20140187772 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS - This invention describes novel pyrazole compounds of formula III: | 2014-07-03 |
20140187773 | TENOFOVIR ALAFENAMIDE HEMIFUMARATE - A hemifumarate form of 9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine (tenofovir alafenamide), and antiviral therapy using tenofovir alafenamide hemifumarate (e.g., anti-HIV and anti-HBV therapies). | 2014-07-03 |
20140187774 | METHODS FOR PREPARING PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS - A method of preparing a compound represented by Structural Formula (I): | 2014-07-03 |
20140187775 | COMPOSITION FOR REDUCING SKIN WRINKLES INCLUDING PDE5 INHIBITOR - Disclosed is a composition effective in reducing skin wrinkles. The composition comprises a phosphodiesterase 5 (PDE5) inhibitor, preferably the compound of chemical formula 1, more preferably, mirodenafil as an active ingredient. Further disclosed is a method for reducing skin wrinkles using the composition. | 2014-07-03 |
20140187776 | MIXTURES OF MESOIONIC PESTICIDES - Disclosed are compositions comprising (a) at least one compound selected from compounds of Formula 1, N-oxides, and salt thereof, | 2014-07-03 |
20140187777 | MATERIALS AND METHODS FOR THE BASE-ASSISTED SYNTHESIS OF SUBSTITUTED HETEROAROMATIC COMPOUNDS - Disclosed herein are some methods for synthesizing the base-assisted coupling of aromatic alcohols with substituted aromatic compounds including some substituted heteroaromatic compounds such as pyrimidines or pyridines to form esters. The reactions may include inexpensive bases such as potassium hydroxide and take place in a solvent mixture comprised primarily of hindered tertiary alcohols that are at least partially immiscible with water. In some embodiments the tertiary alcohol solvents forms azeotropes with water which stabilize the formation of an alkoxide intermediate when the alkoxide formation step is heated to the boiling point of the azeotrope and water is withdrawn from the reaction mixture. | 2014-07-03 |
20140187778 | PEST CONTROL COMPOSITION - Disclosed is a pest control composition having an excellent controlling effect on pests, which comprises etoxazole and fenazaquin. | 2014-07-03 |
20140187779 | Process for preparing [4,6-bis-dimethylamino-2-[4-(4-trifluoromethylbenzoylamino)benzyl]pyrimid- in-5-yl]acetic acid - The present invention relates to a process for preparing a compound of formula (I). | 2014-07-03 |
20140187780 | 6,11-BRIDGED BIARYL MACROLIDES - The present invention discloses compounds of formula I, II or X, or pharmaceutically acceptable salts, esters, or prodrugs thereof: | 2014-07-03 |
20140187781 | AMINOPYRIDINES AND AMINOPYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES - The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions. | 2014-07-03 |
20140187782 | METHOD FOR PRODUCING BENZO[B]THIOPHENE COMPOUND - The present invention provides a method for producing a compound of Formula (4): wherein R | 2014-07-03 |
20140187783 | Hafnium Containing Hydrosilylation Catalysts and Compositions Containing the Catalysts - A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition is capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a metal-ligand complex that can be prepared by a method including reacting a metal precursor and a ligand. | 2014-07-03 |
20140187784 | RADIOACTIVE QUINOLINONE DERIVATIVE AND PHARMACEUTICAL DRUG COMPRISING THE SAME - It is intended to provide a radioactive compound that has higher selectivity for CYP11B2 than that for CYP11B1, exhibits highly selective accumulation in the adrenal gland compared with blood and organs adjacent to the adrenal gland, and permits commercial supply. The present invention provides a radioactive quinolinone derivative represented by the predetermined general formula or a salt thereof. | 2014-07-03 |
20140187785 | PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES BY CATALYTIC ASYMMETRIC HYDROGENATION OF AN ENAMINE - The invention relates to a process for the preparation of pyrido[2,1-a]isoquinoline derivatives of the formula | 2014-07-03 |
20140187786 | 1,3,4-TRISUBSTITUTED BENZENES - Compounds that are 1,3,4-trisubstituted benzenes which modulate (e.g., inhibit) the activity of γ-secretase. The compounds are expected to reduce the level of Aβ42 in patients and be useful in the treatment of diseases (e.g., Alzheimer's disease) characterized by elevated levels of Aβ42 and/or the formation of Aβ plaques. | 2014-07-03 |
20140187787 | PROCESS FOR PREPARING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR - The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith. | 2014-07-03 |
20140187788 | PROCESSES FOR THE PREPARATION OF THIETANAMINE - The present invention provides processes for the preparation of compounds of formula (I) including processes comprising a. reacting a a compound comprising a thietane moiety in which the carbon atom at the 3 position of the thietane moiety is bonded to a nitrogen atom; wherein the nucleophile is selected the group consisting of: N | 2014-07-03 |
20140187789 | NEW PROCESSES FOR PREPARING 4-SUBSTITUTED IMIDAZOLES - There is provided a novel process for the preparation of a compound of formula (I), (Formula (I)). There is also provided novel processes to intermediates of the compound of formula (I), as well as novel intermediates themselves. | 2014-07-03 |
20140187791 | Carbazole Derivative and Method for Producing the Same - To provide a method for producing a wide variety of carbazole derivatives which have a simple and uncomplicated process and in which variations in the yield, purity, etc. of a desired substance which are caused by an aryl group introduced is reduced as much as possible. A method for producing a carbazole derivative represented by General Formula (1) is provided, in which 9-[4-(10-phenyl-9-anthryl)phenyl]-9H-carbazole having an active site at the 3-position of the carbazole skeleton and an aromatic compound having an active site are coupled. | 2014-07-03 |
20140187792 | CONDENSED POLYCYCLIC AROMATIC COMPOUND, AROMATIC POLYMER, AND METHOD FOR SYNTHESIZING AROMATIC COMPOUND - Provided is a condensed polycyclic aromatic compound that can be used as a precursor for synthesizing a condensed polycyclic aromatic compound having relatively high solubility. Also provided is a method for synthesizing and using such a novel condensed polycyclic aromatic compound. The condensed polycyclic aromatic compound is represented by formula (II): (II) (where X | 2014-07-03 |
20140187793 | PROCESSES FOR THE PREPARATION OF 5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID AND ITS DERIVATIVES - The present invention relates generally to an improved process for the preparation of 5-azaspiro[2.4]heptane-6-carboxylic acid and its derivatives which are useful intermediates in the synthesis of biologically active molecules, especially in the synthesis of hepatits C virus NS5A inhibitors. In particular, the present invention relates to processes and intermediates for the preparation of compounds of formulae (Ia), (Ib) and (Ic): | 2014-07-03 |
20140187794 | Process for Preparing Chiral Compounds - The present invention is directed to a 2-deoxyribose-5-phosphate aldolase (DERA) chemoenzymatic process for making chiral compounds. | 2014-07-03 |
20140187795 | CRTH2 MODULATORS AND PREPARATION THEREOF - The present invention relates to processes and intermediates for the preparation of compounds useful as CRTH2 antagonists. Compounds prepared by the processes of the invention are of Formula (AI), (All) and Compound (I). | 2014-07-03 |
20140187796 | PROCESS FOR THE TREATMENT OF A RECYCLYING STREAM FROM A PLANT FOR THE PRODUCTION OF POLYARYLENE ETHER SULFONES - A process is proposed for the treatment of a recycling stream ( | 2014-07-03 |
20140187797 | LEAVING SUBSTITUENT-CONTAINING COMPOUND, ORGANIC SEMICONDUCTOR MATERIAL, ORGANIC SEMICONDUCTOR FILM CONTAINING THE MATERIAL, ORGANIC ELECTRONIC DEVICE CONTAINING THE FILM, METHOD FOR PRODUCING FILM-LIKE PRODUCT, PI-ELECTRON CONJUGATED COMPOUND AND METHOD FOR PRODUCING THE PI-ELECTRON CONJUGATED COMPOUND - A leaving substituent-containing compound including a partial structure represented by the following General Formula (I): | 2014-07-03 |
20140187798 | METHOD FOR PREPARING LACTIDE USING AN IONIC SOLVENT - Disclosed is a method for preparing lactide by using a solvent. According to the method, since an ionic liquid is used as a solvent in a second step in the course of preparing lactide, it is possible to secure mobility of the resulting reactant, and decrease a reaction temperature. In addition, the ionic liquid absorbs moisture generated during the reaction, and thus prevents degradation of lactide which is susceptible to moisture. Furthermore, to the present method allows for the preparation of lactide successively through the continuous supply of lactic acid oligomers. Because the use of an ionic liquid minimizes the contamination of a reactive group with by-products, the use of a solvent for reactor washing is unnecessary. Further, owing to a high boiling point of the ionic liquid, the ionic liquid can be easily harvested and recycled. | 2014-07-03 |
20140187799 | Simplified Process to Extract Quassinoids - Improved processes for the extraction of quassinoids such as quassin and neoquassin from natural substances containing these compounds are described. The process uses compounds that are Generally Recognized As Safe by the U.S. Food and Drug Administration. In a first embodiment, the process includes a sonication method using water and no organic solvent. The process is highly efficient and comprises fewer steps than other processes known in the art. In a second embodiment, a method of extracting quassinoids from natural substance comprising bark of a plant of the plant family Simaroubaceae is also disclosed. In a third embodiment, indirect sonication of quassinoids is described using a mixture of polar and non-polar organic solvents. | 2014-07-03 |
20140187800 | FULLERENE-CONTAINING HEMICARCEPLEXES AND A METHOD OF PURIFYING FULLERENES BY USING THE SAME - Fullerene⊙CTV complexes, comprising fullerene⊙CTV hemicarceplexes, formed by various cyclotriveratrylene (CTV)-based molecular cages and various fullerene guests are disclosed. A method of direct isolating at least a fullerene from fullerene mixtures by using the above fullerene CTV hemicarceplexes but without using crystallization or HPLC is also disclosed. | 2014-07-03 |
20140187801 | ASYMETRIC SYNTHESIS OF NORCANTHARIDIN ANALOUGUS BY ALKYNYLATION OF OXABENZONORBORNADIENES AND THEIR ANTICANCER ACTIVITIES - The present invention relates to a type of norcantharidin analogues and a method to synthesis such norcantharidin analogues by transition metal-catalyzed alkynylation of 7-oxabenzonorbornadienes. The present invention also relates to the use of such norcantharidin analogues in manufacture of a medicament for the treatment of cancer tumors. | 2014-07-03 |
20140187802 | Efficient, high-yield conversion of saccharides in a pure or crude form to 5-(chloromethyl)-2-furaldehyde - The present invention describes methods and apparatuses for the synthesis of 5-(chloromethyl)-2-furaldehyde (CMF) from saccharides in pure or crude form, the method comprising: (a) continuously contacting saccharides in pure or crude form, hydrochloric acid, and an organic solvent, by way of a continuous, biphasic-flow reactor assembly at a temperature from about 60 degrees C. to about 200 degrees C. and pressures from about 1 atmosphere to about 20 atmospheres, such that CMF is produced; (b) separating 5-(chloromethyl)-2-furaldehyde by liquid/liquid and solid/liquid phase separation; (c) producing at least five kilograms per day with at least 50% yield. Embodiments of the present invention can produce CMF in a continuous fashion, with high yield and without degradation of CMF to such side products as 5-(hydroxymethyl)furfural (HMF), 2-(2-hydroxyacetyl)furan (HAF) and levulinic acid (LA). | 2014-07-03 |
20140187803 | Method for the Preparation of Palladium(I) Tri-Tert-Butylphosphine Bromide Dimer and Process for its Use in Isomerization Reactions - The invention provides a new method for the preparation of the dimeric Pd(l) tri-tert.-butylphosphine bromide complex, characterized by the chemical formula [Pd(μ-Br)(P | 2014-07-03 |
20140187804 | PROCESS FOR REMOVING OXYGENATE FROM AN OLEFIN STREAM - The present invention relates to a process for removing oxygenate from an olefin stream comprising oxygenate, comprising providing to an oxygenate recovery zone the olefin stream comprising oxygenate and a solvent comprising propanol, treating the olefin stream comprising oxygenate with the solvent, and retrieving from the oxygenate recovery zone at least one oxygenate-depleted olefinic product stream comprising olefin and a spent solvent comprising at least part of the oxygenate. | 2014-07-03 |
20140187805 | PROCESS FOR REMOVING OXYGENATE FROM AN OLEFIN STREAM - The present invention relates to a process for removing dimethylether from an olefin stream comprising dimethylether, comprising: (a) providing to an oxygenate recovery zone the olefin stream comprising dimethylether and a methanol-comprising solvent, treating the olefin stream comprising dimethylether with the methanol comprising solvent, and retrieving at least a dimethylether-depleted, methanol-comprising olefin stream; and (b) providing to the oxygenate recovery zone a non-aqueous C2 to C4 alcohol solvent and treating the dimethylether-depleted, methanol-comprising olefin stream with the non-aqueous C2 to C4 alcohol solvent, and retrieving from the oxygenate recovery zone at least an olefinic product that is depleted in dimethylether and methanol and a spent solvent comprising at least one C2 to C4 alcohol and methanol. | 2014-07-03 |
20140187806 | PROCESS FOR REMOVING OXYGENATE FROM AN OLEFIN STREAM - The present invention relates to a process for producing an olefinic product, comprising (a) preparing a reaction product by converting an oxygenate-comprising feedstock in an oxygenate to olefin process, the reaction product comprising at least C2+ olefins and DME, (b) separating at least part of the reaction product by means of extractive distillation using a butanol solvent into: (i) a first fraction comprising C3− olefins and butanol; and (ii) a second fraction comprising C4+ olefins, DME and butanol; (c) separating the first fraction into: (iii)a C3− olefinic product; and (iv) a third fraction comprising butanol; (d) separating the second fraction into: (v) a DME-comprising C4-C5 olefinic product; and (vi) a fourth fraction comprising butanol and C6+ olefins, wherein at least part of the third and/or fourth fraction are recycled to step (b) together with or as part of the butanol solvent. | 2014-07-03 |
20140187807 | START-UP PROCESS FOR HIGH SELECTIVITY ETHYLENE OXIDE CATALYSTS - A high selectivity catalyst start-up process is provided in which an excess level of chloride moderator (greater than 1 ppm) is present in the feed gas composition during each of the various stages of the start-up process. The excess level of chloride used in the start-up process maintains a low level of selectivity (less than 86%) during the entire start-up process. Despite the low selectivity values achieved during the start-up process of the present disclosure, high selectivity catalysts that are conditioned by such a start-up process exhibit improved catalyst performance during the normal operation of the catalyst. | 2014-07-03 |
20140187808 | METHOD FOR SYNTHESIZING AN OMEGA-AMINO ACID OR ESTER FROM A MONOUNSATURATED FATTY ACID OR ESTER - A method for synthesizing ω-amino-alkanoic acids or the esters thereof from natural unsaturated fatty acids passing through an intermediate ω-unsaturated nitrile compound. The method is simple to implement and, relative to known methods, avoids the environmental constraints and economic disadvantages resulting from the reaction by-products. The method includes synthesizing an ω-amino acid (ester) of formula R3OOC—(CH2) | 2014-07-03 |
20140187809 | NOVEL RUTHENIUM COMPLEX AND PROCESS FOR PRODUCING OPTICALLY ACTIVE ALCOHOL COMPOUND USING SAME AS CATALYST - The present invention provides a novel ruthenium complex which has an excellent catalytic activity in terms of reactivity for an asymmetric reduction of a carbonyl compound and enantioselectivity, a catalyst using the ruthenium complex, and a method for preparing optically active alcohol compounds using the ruthenium complex. The present invention relates to a ruthenium complex having a ruthenacycle structure, a catalyst for an asymmetric reduction consisting of the ruthenium complex, and a method for preparing optically active alcohol compounds using the ruthenium complex. | 2014-07-03 |
20140187810 | STABILIZED COMPOSITIONS OF ALKYLATING AGENTS AND METHODS OF USING SAME - Provided are stable compositions comprising alkylating agents, including nitrogen mustards, that are suitable for topical use, and methods for treating skin disorders comprising topically administering the compositions. | 2014-07-03 |
20140187811 | PROCESS FOR THE PREPARATION OF BETA-SANTALOL - The present invention concerns a process for the preparation of a compound of formula (I) in the form of any one of its stereoisomers or mixtures thereof, wherein R represents a C | 2014-07-03 |
20140187812 | SYSTEMS AND METHODS FOR PROCESSING VARIABLE ACETYL STREAMS - The invention provides systems and processes for concentrating acetic acid and acetic anhydride streams. The systems allow operation of equipment used for such concentrations in two or more modes of operation. At least one mode is intended to produce a concentrated or purified acetic acid stream. At least one other mode is intended to produce a concentrated or purified acetic anhydride stream. | 2014-07-03 |
20140187813 | CRYSTALLINE POLYMORPHIC FORMS OF MONOSODIUM N-[-8-(2-HYDROXYBENZOYL)AMINO]CAPRYLATE - The present invention relates to crystalline polymorphic forms of monosodium N-[8-(2-hydroxybenzoyl)amino]caprylate (“SNAC”), including two hydrates, a methanol solvate, and an ethanol solvate, of SNAC. More specifically, the present invention provide six polymorphic forms of SNAC (hereafter referred to as Forms I-VI). The present invention also provides an amorphous form of SNAC. | 2014-07-03 |
20140187814 | TYROSINE DERIVATIVE AND METHOD FOR PRODUCING TYROSINE DERIVATIVE - The objective of the present invention is to provide a tyrosine derivative which is useful as a melatonin MT | 2014-07-03 |
20140187815 | Process for preparation of l-arginine alpha-ketoglutarate 1:1 and 2:1 - A process for preparation of α-ketoglutaric acid, L-arginine α-ketoglutarate 1:1 and 2:1, comprising the steps of: providing a α-ketoglutaratic acid aqueous solution at an adjusted concentration; adding one equivalent mole of solid L-arginine to the α-ketoglutaratic acid aqueous solution; stirring and allowing reaction under a controlled temperature; (e) obtaining a resulting L-arginine α-ketoglutarate 1:1 solution with a pH of approximately 3˜4 or L-arginine α-ketoglutarate 2:1 solution with a pH of approximately 6.5˜7; and obtaining a final product of L-arginine α-ketoglutarate 1:1 or 2:1 through spay drying. The yield of the final product is approximately 94% for L-arginine α-ketoglutarate 1:1 and 97% for L-arginine α-ketoglutarate 2:1 through the process. Large amount of solvents is eliminated and reaction time is shortened but the yield is increased, hence realizing mass production through reactor in a cost and time effective manner. | 2014-07-03 |
20140187816 | METHOD FOR RECOVERING ANIONIC FLUORINATED EMULSIFIER - To provide a method for recovering an anionic fluorinated emulsifier, whereby an anionic fluorinated emulsifier adsorbed on a basic ion exchange resin can be simply and efficiently recovered. A mixed liquid of an aqueous inorganic acid solution, a fluorinated medium and a non-fluorinated medium, is contacted to a basic ion exchange resin having an anionic fluorinated emulsifier adsorbed thereon, to recover a liquid phase containing the fluorinated medium, or an aqueous inorganic acid solution is contacted to a basic ion exchange resin having an anionic fluorinated emulsifier adsorbed thereon, then a mixed liquid of a fluorinated medium and a non-fluorinated medium is contacted thereto, and thereafter the basic ion exchange resin and a liquid phase are separated to recover the liquid phase, whereupon from each liquid phase, an acid of the anionic fluorinated emulsifier is recovered. | 2014-07-03 |
20140187817 | PREPARATION OF METHACRYLIC ACID - The invention relates to a process for preparation of methacrylic acid, comprising process steps a) providing a crude methacrylic acid-comprising aqueous solution comprising at least one impurity at least partially dissolved therein; b) precipitation of at least a part of the at least one impurity from the crude methacrylic acid-comprising aqueous solution to form at least one solid impurity and a mother liquor; c) separation of at least a part of the at least one solid impurity from the mother liquor to obtain a purified methacrylic acid-comprising aqueous solution and a solid impurity; d) separation of methacrylic acid from the purified methacrylic acid-comprising aqueous solution. | 2014-07-03 |
20140187818 | BACTERIAL STRAIN RHODOCOCCUS AETHERIVORANS VKM Ac-2610D PRODUCING NITRILE HYDRATASE, METHOD OF ITS CULTIVATION AND METHOD FOR PRODUCING ACRYLAMIDE - The invention relates to a bacterial strain belonging to the genus | 2014-07-03 |
20140187819 | METHOD FOR PREPARATION OF ARYL POLY(OXALKYL) QUATERNARY AMMONIUM COMPOUND - A method for preparation of an aryl poly(oxalkyl) quaternary ammonium compound is provided, said method comprising steps of: 1) reacting a phenol with a dihalopolyalkylene ether under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) halide; 2) reacting said arylpoly(oxalkyl) halide with an amination reagent under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) amine; 3) reacting said arylpoly(oxalkyl) amine with an alkylation reagent, to obtain an aryl poly(oxalkyl) quaternary ammonium compound; wherein R | 2014-07-03 |
20140187820 | POLYHYDROXY-DIAMINES AS MULTI-FUNCTIONAL ADDITIVES FOR PAINTS, COATINGS AND EPOXIES - Provided are polyhydroxy-diamine compounds of the formula I: | 2014-07-03 |
20140187821 | Process for Producing Cycloalkylaromatic Compounds - In a process for producing a cycloalkylaromatic compound, an aromatic compound and a cyclic olefin are contacted with a first catalyst under conditions effective to produce a reaction product comprising the cycloalkylaromatic compound and at least one non-fused bicyclic by-product. The at least one non-fused bicyclic by-product is then contacted with a second catalyst under conditions effective to convert at least a portion of the at least one non-fused bicyclic by-product to a converted by-product. | 2014-07-03 |
20140187822 | METHOD FOR PRODUCING 2-CHLOROMETHYLBENZALDEHYDE, 2-CHLOROMETHYLBENZALDEHYDE-CONTAINING COMPOSITION, AND METHOD FOR STORING SAME - A process for obtaining an industrially useful 2-chloromethylbenzaldehyde-containing liquid composition at a high yield is provided. More specifically, a process for producing 2-chloromethylbenzaldehyde comprising step (A) of mixing 1-dichloromethyl-2-chloromethylbenzene and sulfuric acid having a concentration of 84.5% by weight or more; and step (B) of mixing a mixture obtained in step (A) and water is provided. | 2014-07-03 |
20140187823 | PROCESS FOR THE PRODUCTION OF PURE METHYLAL - The invention relates to a continuous process to make and isolate methylal by reacting formaldehyde and methanol with an acid catalyst under at least partial formation of methylal and water, to form a mixture M2 comprising formaldehyde, methanol, methylal, and water, separating the said mixture M2 in a distillation column B into three distinct product streams, one being a distillate taken from the column head BH which is rich in methylal, one taken from the column bottom stream BB being almost pure water, and one taken from the side of the column B below the reaction zone which stream is rich in methanol, characterised in that the ratio of the amount of substance of methanol to the amount of substance of formaldehyde in the mixture M1 is at least 3 mol/mol, and to an apparatus to be used with this process. | 2014-07-03 |
20140187824 | PROCESS FOR THE PREPARATION OF AN OLEFINIC PRODUCT COMPRISING ETHYLENE AND/OR PROPYLENE - An oxygenate to olefins (OTO) process, comprising the steps of: (i) purifying an oxygenate feedstream comprising one or more ionic contaminants by contacting the feedstream with a membrane, resulting in the formation of a retentate and a permeate separated by the membrane, which permeate is a purified oxygenate stream which contains a lower ionic contaminant concentration than the original oxygenate feedstream; (ii) introducing the purified oxygenate stream into an oxygenate to olefins reaction zone; and (iii) contacting the purified oxygenate stream with a molecular sieve catalyst in the oxygenate to olefins reaction zone to form a product stream comprising olefins. | 2014-07-03 |
20140187825 | LIGNOCELLULOSIC CONVERSION PROCESS INTENSIFICATION - Economic conversion of lignocellulose requires both the maximization of conversion of available carbohydrates, as well as minimization of process capital cost. Process intensification minimizes capital cost while preserving conversion yield by combining into a single step those unit operations that are conducted at similar conditions. Flowsheet variations are proposed that minimize process capital while maintaining overall conversion yield. | 2014-07-03 |
20140187826 | CATALYTIC BIOREACTORS AND METHODS OF USING SAME - Various embodiments provide a bioreactor for producing a bioproduct comprising a housing; and one or more catalytically active zones located in the housing and adapted to keep two incompatible gaseous reactants separated when in a gas phase, wherein each of said catalytically active zone comprises a catalytic component retainer and a catalytic component retained within and/or on the catalytic component retainer. Each of said catalytically active zones may additionally or alternatively comprise a liquid medium located on either side of the catalytic component retainer and the catalytic component may additionally or alternatively be a suspended catalytic component suspended in a liquid medium located on either side of the catalytic component retainer. Methods of using various embodiments of the bioreactor to produce a bioproduct, such as isobutanol, are also provided. | 2014-07-03 |
20140187827 | BLENDING OF DEWAXED BIOFUELS WITH MINERAL-BASED KERO(JET) DISTILLATE CUTS TO PROVIDE ON-SPEC JET FUELS - The present invention describes a method of making a jet fuel composition comprising: providing a mineral-based kero/jet-type distillate component having certain enumerated physico-chemical properties, typically an off-spec jet fuel; providing a deoxygenated and dewaxed renewable component derived from triglycerides and/or fatty acids and having an isoparaffin to normal paraffin ratio from about 2:1 to about 6:1 and an aromatics content less than about 1 vol %; and blending from about 75 vol % to about 97 vol % of the mineral-based distillate components with from about 3 vol % to about 25 vol % of the renewable component to form an on-spec blended jet fuel composition. | 2014-07-03 |
20140187828 | LIQUID FUEL COMPOSITIONS - A moderate fraction of a carbohydrate derived component, and a kerosene composition comprising the moderate fraction, the moderate fraction having at least one C | 2014-07-03 |
20140187829 | Method of Producing Natural B Carotene By Fermentation And Use Thereof - The present invention provides a method for producing and purifying β-carotene by | 2014-07-03 |
20140187830 | METHODS FOR PRODUCING SYNTHETIC FUEL - Methods are disclosed for producing synthetic fuel from carbon-containing polymeric feedstock using a select catalyst mixture. | 2014-07-03 |
20140187831 | PROCESS FOR INCREASING BENZENE AND TOLUENE PRODUCTION - A process for reforming a hydrocarbon stream is presented. The process involves splitting a naphtha feedstream to at least two feedstreams and passing each feedstream to separation reformers. The reformers are operated under different conditions to utilize the differences in the reaction properties of the different hydrocarbon components. The process utilizes a common catalyst, and common downstream processes for recovering the desired aromatic compounds generated. | 2014-07-03 |
20140187832 | PROCESS FOR INCREASING BENZENE AND TOLUENE PRODUCTION - A process for reforming a hydrocarbon stream is presented. The process involves splitting a naphtha feedstream to at least two feedstreams and passing each feedstream to separation reformers. The reformers are operated under different conditions to utilize the differences in the reaction properties of the different hydrocarbon components. The process utilizes a common catalyst, and common downstream processes for recovering the desired aromatic compounds generated. | 2014-07-03 |
20140187833 | INTEGRATED PROCESS FOR THE PREPARATION OF OLEFINS - The invention provides a process for preparing olefins, comprising: (a) reacting an oxygenate and/or olefinic feed in a first reactor in the presence of a molecular sieve catalyst to form a first effluent comprising olefins; (b) fractionating at least part of the first effluent into an olefinic product fraction comprising ethylene and propylene and an olefinic product fraction comprising olefins containing 4 or more carbon atoms; (c) subjecting a paraffin-containing hydrocarbon feedstock in a second reactor to a steam cracking process to form a second effluent comprising olefins including butadiene; (d) fractionating the second effluent into an olefinic product fraction comprising ethylene and/or propylene and an olefinic product fraction comprising mono-olefins containing 4 or more carbon atoms; and (e) recycling the olefinic product fraction comprising at least part of the ethylene and/or propylene as obtained in step (d) to the reactor in step (a). | 2014-07-03 |
20140187834 | PROCESS FOR EXTRACTING C4+ OLEFINS AND A PROCESS FOR CONVERTING OXYGENATES TO OLEFINS - The current invention provides a process for extracting C4+ olefins from a stream comprising C4+ olefins and C4+ paraffins, wherein an oxygenate, preferably methanol (MeOH) is used as extractant, and wherein the resulting extract phase comprising C4+ olefins and extractant is converted into olefins. Also provided is a process for converting oxygenates to olefins, wherein the oxygenate preferably comprises MeOH, wherein the oxygenate is used as extractant and wherein an extract phase comprising C4+ olefins and the extractant are converted into olefins. | 2014-07-03 |
20140187835 | PROCESS FOR THE PREPARATION OF AN OLEFINIC PRODUCT FROM AN OXYGENATE - The invention relates to a process for the preparation of ethylene and/or propylene comprising: (a) an oxygenate conversion step wherein a gaseous effluent comprising olefins is obtained; (b) subjecting the effluent to water removal and compression steps; (c) acid gas removal from the effluent obtained in step (b), wherein the gaseous effluent is treated with a caustic solution and a non-aqueous liquid stream comprising aromatic C7 | 2014-07-03 |
20140187836 | PROCESS FOR REMOVING OXYGENATE FROM AN OLEFIN STREAM - The present invention relates to a process for removing oxygenate from an olefin stream comprising oxygenate, comprising providing to an oxygenate recovery zone the olefin stream comprising oxygenate and a liquid solvent comprising: (a) butanol; (b)alkyl tert-alkyl ether; or (c) alkyl tert-alkyl ether and butanol, treating the olefin stream comprising oxygenate with the liquid solvent, and retrieving from the oxygenate recovery zone at least one oxygenate-depleted olefinic product stream comprising olefin and a spent liquid solvent comprising at least part of the oxygenate. | 2014-07-03 |
20140187837 | METHODS AND APPARATUSES FOR REFORMING OF HYDROCARBONS INCLUDING RECOVERY OF PRODUCTS - Embodiments of apparatuses and methods for reforming of hydrocarbons including recovery of products are provided. In one example, a method comprises separating a reforming-zone effluent into a H | 2014-07-03 |
20140187838 | SOUR GAS AND ACID NATURAL GAS SEPARATION MEMBRANE PROCESS BY PRE REMOVAL OF DISSOLVED ELEMENTAL SULFUR FOR PLUGGING PREVENTION - Methods for removing sulfur from a gas stream prior to sending the gas stream to a gas separation membrane system are provided. Two schemes are available. When the sulfur content is high or flow is relatively high, a scheme including two columns where one tower is regenerated if the sulfur concentration exceeds a preset value can be used. When the sulfur content is low or flow is relatively low, a scheme including one column and an absorption bed. | 2014-07-03 |
20140187839 | PURIFICATION OF ISOPRENE FROM RENEWABLE RESOURCES - Methods and apparatus for the purification of isoprene, such as the purification of a bioisoprene composition from fermentor off-gas. The apparatus includes two columns that process the fermentor off-gas, which includes isoprene and various impurities. A solvent is added to the off-gas in the first column, and the isoprene is stripped from the solvent in the second column. Also provided is a downstream further purification process. Also provided are the resulting purified isoprene compositions. | 2014-07-03 |
20140187840 | PROCESS FOR SEPARATING BY ABSORPTION THE PYROLYSIS GAS FROM PREPARATION OF LOWER CARBON OLEFINS - The provided is a process for separating by absorption the pyrolysis gas from preparation of lower carbon olefins, wherein a primary absorbent and a secondary absorbent are introduced into the demethanizer to separate by absorption the feedstock of the demethanizer through countercurrent contact therewith at a moderate temperature and pressure, thereby to obtain a top fraction primarily comprising hydrogen and methane and a bottom fraction primarily comprising the absorbents and C2+ fraction, wherein the primary absorbent essentially is a mixed Cn or Cn+ fraction, the secondary absorbent essentially is a Cn′ alkane fraction or mixed Cn′ or Cn′+ fraction, and wherein n and n′ are independently 3, 4 or 5 with the proviso when the secondary absorbent is a mixed fraction, n′ is not 3. | 2014-07-03 |
20140187841 | APPARATUSES AND METHODS FOR SEPARATING LIQUEFIABLE HYDROCARBONS FROM HYDROGEN-, HYDROCARBON-CONTAINING GAS STREAMS - Embodiments of apparatuses and methods for separating liquefiable hydrocarbons from H | 2014-07-03 |
20140187842 | Device for Disposal and Neutralization of Pharmaceutical Agents - Device for the neutralization and disposal of unused human or animal pharmaceutical medicament. The device comprises a disposal device material that contains one or more disposal device agents. The disposal device material may also contain additional components to promote mixing, or neutralization of the active agent of the medicament. The disposal device material can be in the form of pellets, beads, beadlets, granules, or the like, and can be incorporated into a disposal device reservoir. The disposal device can be dispensed with a medicament, and the device can be used when the patient has finished using the medicament and there is material left over for disposal. | 2014-07-03 |
20140187843 | RADIOISOTOPE-PHOTODYNAMIC THERAPY FOR CANCER TREATMENT - The present invention provides compositions and methods for radioisotope-photodynamic therapy for treating cancer. Specifically, the invention relates to compositions and methods for administering a radiation emitter, a rare-earth doped down-converting nanophosphor and a photosensitizer for treating cancer. | 2014-07-03 |
20140187844 | PARTICLE BEAM THERAPY SYSTEM - A particle beam therapy system is disclosed which includes: a synchrotron accelerating a charged particle beam injected from a pre-accelerator up to a predetermined energy level before applying a high-frequency voltage to an extraction device to extract the charged particle beam caused to exceed a stability limit; a beam transportation system transporting the charged particle beam extracted from the synchrotron up to a treatment room, and an irradiation device irradiating a patient in the treatment room with the charged particle beam in conformity to the patient's tumor shape. The synchrotron has functionality to accelerate or decelerate the charged particle beam successively to extract the charged particle beam at a plurality of energy levels during an extraction phase of the synchrotron, the beam transportation system further having functionality to block off an unnecessary charged particle beam extracted from the synchrotron during acceleration or deceleration. | 2014-07-03 |