29th week of 2022 patent applcation highlights part 26 |
Patent application number | Title | Published |
20220228066 | A Method for the Preparation of a Stable, Fire-Retardant Composition of Boron-Containing Compounds, the Composition so Obtained and a Method and a Use of Said Composition - A fire-retardant composition having stable physical and chemical properties, comprising a salt of a first boron-containing compound in an amount A, a second boron-containing compound in an amount B, a first solvent comprising at least one organic solvent in an amount C, and a second solvent comprising water in an amount D. With respect to the total weight of the fire-retardant composition, A represents 15 to 45 wt.-%, B represents 15 to 46 wt.-%, C represents 0.2622×the amount B to 0.3944×the amount B wt.-%, and D represents 0.3549×the amount B to 0.4860×the amount B wt.-%. D=(the amount A+the amount B+the amount C); and 100−(the amount A+the amount B+the amount C) is greater that D. A method of preparation, a use and a method for imparting fire-retardant properties to a substrate. | 2022-07-21 |
20220228067 | SURFACTANT COMPOSITION FOR FOAMING SAND - A surfactant composition for a formed sand including 80 to 99.8 mass % of a compound (A) represented by formula (1); 0.1 to 10 mass % of a compound (B) represented by formula (2); and 0.1 to 10 mass % of an amphoteric surfactant (C): | 2022-07-21 |
20220228068 | PLASTIC PYROLYSIS/EMULSIFICATION SYSTEM - The present disclosure relates to a plastic pyrolysis/emulsification system for pyrolyzing waste plastic in a high-temperature/high-vacuum environment, the plastic pyrolysis/emulsification system being characterized by comprising: an introduction portion having a hopper for introducing plastic; a heating furnace having a burner mounted thereon so as to establish a high-temperature environment therein and having a combustion gas outlet; a melting furnace penetrating the heating furnace such that one end of the melting furnace is connected to the introduction portion, and both ends thereof are exposed to the outside, a transferring/compressing means being mounted in the melting furnace along the longitudinal direction so as to transfer and compress the plastic in one direction, thereby transferring, compressing, and melting the plastic, and the melting furnace having a vapor outlet for discharging water vapor resulting from compression and melting of the plastic; a first transfer portion connected to the other end of the melting furnace so as to transfer the melt of the plastic; a vacuum pyrolysis furnace penetrating the heating furnace such that one end of the vacuum pyrolysis furnace is connected to the first transfer portion, and both ends thereof are exposed to the outside, a transfer means being mounted in the vacuum pyrolysis furnace along the longitudinal direction so as to transfer the melt in one direction, thereby transferring and pyrolyzing the melt, and the vacuum pyrolysis furnace having an oil vapor outlet for discharging oil vapor resulting from transfer and pyrolysis of the melt; a second transfer portion connected to the other end of the vacuum pyrolysis furnace so as to transfer the pyrolysis remnant of the melt; a discharge portion connected to the second transfer portion so as to discharge the pyrolysis remnant; a first condenser connected to the vapor outlet so as to condense the water vapor; a second condenser connected to the other end of the vacuum pyrolysis furnace so as to transfer the pyrolysis remnant of the melt; a discharge portion connected to the second transfer portion so as to discharge the pyrolysis remnant; a first condenser connected to the vapor outlet so as to condense is the water vapor; a second condenser connected to the oil vapor outlet so as to condense the oil vapor; multiple third condensers connected to the second condenser via first, second, and third valves, respectively; a vacuum pump connected to the multiple third condensers via fourth, fifth, and sixth valves, respectively; and a fourth condenser connected to the vacuum pump. | 2022-07-21 |
20220228069 | COMPOSITIONS AND METHODS FOR IMPROVED HANDLING AND COMBUSTION OF PETROLEUM PITCH - This alternative fuel is a reclaimed waste product which has a solid, particulate consistency at ambient temperature. The fuel comprises a composite of petroleum pitch and a powder coating. The powder coating penetrates into the surface of the pitch. The powder coating is recycled ash, pulverized coal, or pulverized petroleum coke. | 2022-07-21 |
20220228070 | CONVERSION OF WASTE PLASTICS TO PETROCHEMICALS - Process and systems for converting waste plastics include feeding a waste plastic to a melt tank, and in the melt tank, heating the waste plastic to form a molten plastic. The molten plastic is withdrawn from the melt tank and fed to a pyrolysis reactor. In the pyrolysis reactor, the molten plastic is heated to a pyrolysis temperature, producing a pyrolysis oil product and a liquid pitch product. The pyrolysis oil is then separated into a pyrolysis gas fraction, a light pyrolysis oil fraction, a medium pyrolysis oil fraction, and a heavy pyrolysis oil fraction. | 2022-07-21 |
20220228071 | CRACKING A C4-C7 FRACTION OF PYOIL - A hydrocarbon cracker stream is combined with recycle content pyrolysis oil to form a combined cracker stream and the combined cracker stream is cracked in a cracker furnace to provide an olefin-containing effluent. The r-pyoil can be fed to the cracker feed. Alternatively, the r-pyoil with a predominantly C | 2022-07-21 |
20220228072 | Method of Hydrocarbon Pyrolysis and Device for Implementing Same - A method of oxidative pyrolysis involves heating hydrocarbon feedstock, heating a steam-oxygen mixture, combusting hydrocarbon feedstock in vapors of a steam-oxygen mixture in a special reactor, rapidly cooling the obtained products of incomplete combustion of chemical reactions in two steps, after which the cooled steam-gas mixture is directed to the fractionation unit. A hydrocarbons pyrolysis device has a steam-oxygen mixture and feedstock mixing chamber, a pyrolysis chamber and a coking reactor, a device for heating hydrocarbon feedstock, a device for heating steam-oxygen mixture coupled to a mixing chamber, a coking reactor having a device for supplying coolant to the pyrogas flow, a separation unit coupled to the coking reactor, a fractionation unit with an additional coolant supply device. Disposal of heavy oil residues by rapid coking with high economic efficiency and environmental safely while obtaining high-quality coke and producing aromatic compounds occurs without construction or additional installations. | 2022-07-21 |
20220228073 | CYCLIZATION AND FLUID CATALYTIC CRACKING SYSTEMS AND METHODS FOR UPGRADING NAPHTHA - A process for upgrading a naphtha feed includes separating the naphtha feed into at least a light naphtha fraction, contacting the light naphtha fraction with hydrogen in the presence of at least one cyclization catalyst, and contacting the cyclization effluent with at least one cracking catalyst. Contacting the light naphtha fraction with hydrogen in the presence of at least one cyclization catalyst may produce a cyclization effluent comprising a greater concentration of naphthenes compared to the light naphtha fraction. Contacting the cyclization effluent with at least one cracking catalyst under conditions sufficient to crack at least a portion of the cyclization effluent may produce a fluid catalytic cracking effluent comprising light olefins, gasoline blending components, or both. A system for upgrading a naphtha feed includes a naphtha separation unit, a cyclization unit disposed downstream of the naphtha separation unit, and a fluid catalytic cracking unit disposed downstream of the cyclization unit. | 2022-07-21 |
20220228074 | METHOD FOR PRODUCING HIGH QUALITY BASE OILS USING MULTIPLE STAGE PROCESSING - Described are processes to produce base oils with one more improved properties, e.g., lower aromatics, economically and/or efficiently. In some embodiments the processes comprise a step that reduces the amount of residual refractory sulfur compounds prior to or simultaneous with a hydrofinishing step which advantageously provides base oils with lower aromatics than comparable processes. | 2022-07-21 |
20220228075 | APPARATUS AND PROCESS FOR THE ENHANCED PRODUCTION OF AROMATIC COMPOUNDS - Embodiments of the present disclosure are directed to a process for the upgrading of petroleum products comprising subjecting a diesel feed to a hydrocracking process, thereby producing a hydrocrackate fraction; subjecting the hydrocrackate fraction to a catalytic reforming process, thereby producing a reformate; and recovering aromatics from the reformate. In accordance with another embodiment of the present disclosure, a method of producing aromatics may comprise introducing a diesel feed to a hydrocracking unit to produce a hydrocrackate fraction, passing the hydrocrackate fraction to a catalytic reforming unit to produce a reformate, and passing the reformate to an aromatic recovery complex to produce an aromatic fraction. In accordance with yet another embodiment of the present disclosure, an apparatus for the upgrading of petroleum products may comprise a hydrocracker, a catalytic reformer, and an aromatic recovery complex. The hydrocracker may be in fluid communication with the catalytic reformer, the catalytic reformer may be in fluid communication with an aromatic recovery complex, and the hydrocracker may be structurally configured to receive a diesel feed. | 2022-07-21 |
20220228076 | ANTIFOULANT FORMULATION AND APPLICATIONS THEREOF - The present disclosure relates to an antifoulant formulation comprising: (a) at least one ammonium salt of linear alkyl benzene sulphonic acid; (b) at least one aromatic hydrocarbon; (c) at least one diluent; (d) polyisobutylene succinic anhydride; and (e) at least one alkyl amine. It also relates to the process of preparation of the said antifoulant formulation. The instant disclosure further relates to the method of inhibiting fouling tendency in the heat exchangers of crude oil, crude blends, short residue, involving the said antifoulant formulation. | 2022-07-21 |
20220228077 | PRODUCTION METHOD OF SPARK-IGNITION ENGINE FUEL - A production method of spark-ignition engine fuel, configured to produce fuel for a spark-ignition engine, includes: mixing a light naphtha with a cyclopentane. | 2022-07-21 |
20220228078 | FUEL COMPOSITION FOR LEAN BURN ENGINE - A fuel composition for a lean burn engine comprising hydrocarbons having 4 to 6 carbon atoms as main component, with an aromatic content of 25 vol % or less. | 2022-07-21 |
20220228079 | NATURAL GAS CONDITIONING - Rich natural gas is first compressed, and then cooled by a series of heat exchangers and an ambient air cooler. The cooled mixture of natural gas, natural gas liquid (NGL), and water is first separated in a high-pressure three-phase separator. NGL flows through a depressurization valve and NGL is separated from gas in a second separator for storage and transport such as in a conventional propane tank. A resulting lean natural gas is suitably conditioned for internal combustion, compressed natural gas processing, or liquid fuel processing. | 2022-07-21 |
20220228080 | BIOCARBON PELLETS WITH ADJUSTABLE GRINDABILITY INDEX - In some variations, the invention provides a biocarbon pellet comprising: 35 wt % to 99 wt % of a biogenic reagent, wherein the biogenic reagent comprises, on a dry basis, at least 60 wt % carbon; 0 wt % to 35 wt % water moisture; and 1 wt % to 30 wt % of a binder, wherein the biocarbon pellet is characterized by an adjustable Hardgrove Grindability Index (HGI) from about 30 to about 120, as shown in the Examples. The pellet HGI is adjustable by controlling process conditions and the pellet binder. The binder can be an organic binder or an inorganic binder. The carbon is renewable as determined from a measurement of the | 2022-07-21 |
20220228081 | PROCESSES FOR PRODUCING BIOCARBON PELLETS WITH ADJUSTABLE GRINDABILITY INDEX - In some variations, the invention provides a biocarbon pellet comprising: 35 wt % to 99 wt % of a biogenic reagent, wherein the biogenic reagent comprises, on a dry basis, at least 60 wt % carbon; 0 wt % to 35 wt % water moisture; and 1 wt % to 30 wt % of a binder, wherein the biocarbon pellet is characterized by an adjustable Hardgrove Grindability Index (HGI) from about 30 to about 120, as shown in the Examples. The pellet HGI is adjustable by controlling process conditions and the pellet binder. The binder can be an organic binder or an inorganic binder. The carbon is renewable as determined from a measurement of the | 2022-07-21 |
20220228082 | REACTIVITY-MODERATED BIOCARBON PELLETS - In some variations, the invention provides a biocarbon pellet comprising: 35 wt % to 99 wt % of a biogenic reagent, wherein the biogenic reagent comprises, on a dry basis, at least 60 wt % carbon; 0 wt % to 35 wt % water moisture; and 1 wt % to 30 wt % of a binder, wherein the biocarbon pellet is characterized by an adjustable Hardgrove Grindability Index (HGI) from about 30 to about 120, as shown in the Examples. The pellet HGI is adjustable by controlling process conditions and the pellet binder. The binder can be an organic binder or an inorganic binder. The carbon is renewable as determined from a measurement of the | 2022-07-21 |
20220228083 | LUBRICANT COMPOSITION AND USE AS A LUBRICANT ADDITIVE OF GUANIDINIUM-BASED IONIC LIQUIDS - Use of a guanidinium-based ionic liquid as detergent in a lubricant composition, notably for lubricating marine engines. A lubricant composition including a guanidinium-based ionic liquid. | 2022-07-21 |
20220228084 | METHOD FOR PRODUCING LUBRICATING OIL COMPOSITION, AND LUBRICATING OIL COMPOSITION - This method for producing a lubricating oil composition includes: a step of dissolving fullerenes in a base oil mainly composed of a multiply alkylated cyclopentane oil or an ionic liquid containing an imide as a negative ion to obtain a fullerene solution; and a step of producing fullerenes adduct by subjecting the above-described fullerene solution to a heat treatment in a non-oxidizing atmosphere. | 2022-07-21 |
20220228085 | FRAGRANCE OR FLAVOUR MIXTURE - Fragrance or flavour mixtures containing (i) (E)-2-methyl-but-2-endicarboxylic acid diesters, (ii) (Z)-2-methyl-but-2-endicarboxylic acid diesters and (iii) 2-methylenebutanedicarboxylic acid diesters with a fruity, pear-like note are provided. Further provided are a process for the preparation of these fragrances or flavourings or fragrance or flavouring mixtures, and the use of the fragrance or flavouring mixtures to produce a fruity, pear-like fragrance or flavour or for the preparation of a fragrance mixture or a perfume oil, cosmetic agent, application agent, detergent and cleaning agent, foodstuff, animal feed or pharmaceutical product, as well as the products made therefrom which contain the fragrance or flavouring mixtures in a sensory effective amount. | 2022-07-21 |
20220228086 | A PROCESS FOR THE OXIDATION OF FATTY ACIDS - The present invention discloses a process for the oxidation of fatty acids comprises reacting fatty acid with O | 2022-07-21 |
20220228087 | COMPOSITION - The present invention relates to a composition capable of improving properties of cleaning a dirt during cleaning. | 2022-07-21 |
20220228088 | ALPHA-AMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME - The present invention relates to alpha-amylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants. | 2022-07-21 |
20220228089 | PEROXIDE COMPOSITION - A shelf stable laundry or hard surface composition comprising hydrogen peroxide is disclosed. The composition can be in the form of a thickened liquid or a gel that can support solid particles and is stable over a normal product shelf life against both precipitation of the particles and degradation of the peroxide and can tolerate a wide range of additional cleaning ingredients. | 2022-07-21 |
20220228090 | METHOD OF LAUNDERING FABRIC - A method of laundering fabric, where the method includes the steps of:
| 2022-07-21 |
20220228091 | METHOD OF LAUNDERING FABRIC - A method of laundering fabric, where the method includes the steps of:
| 2022-07-21 |
20220228092 | SINGLE-USE, FLEXIBLE BIOPROCESSING BAG AND METHOD OF MANUFACTURING A SINGLE-USE, FLEXIBLE BIOPROCESSING BAG - A bioprocessing bag includes a plurality of panels joined to one another about respective edges of the plurality of sheets, by side welds, and a top panel joined to upper edges of the plurality of panels by a flat/convergence weld. | 2022-07-21 |
20220228093 | Artificial Placenta And Methods Of Preparation - The presently disclosed subject matter provides a microfluidic device that can simulate capillary blood flow on a fetal side of the device and pooled blood on a maternal side of the device (i.e., intervillous space). The microfluidic device can reconstitute the maternal-fetal interface, can expand the capabilities of cell culture models, and can provide an alternative to current maternal-fetal transfer models. | 2022-07-21 |
20220228094 | METHOD AND DEVICE TO PROVIDE A MICROFLUIDIC FLOW - A method to provide a microfluidic flow comprising a central flow and at least one outer flow, such that the central flow includes a first material and the at least one outer flow comprises a second material. One of the first material and the second material has cells and the other of the first material and the second material has solid particles. The method involves injection of a first suspension including the first material through a central inlet with a flow rate Q | 2022-07-21 |
20220228095 | THREE-DIMENSIONAL STRUCTURE FOR SUPPORTING CELL CULTURE MEDIUM, AND METHOD FOR MANUFACTURING FILM COMPRISING SAME - The present application relates to a three-dimensional structure for carrying a cell culture medium, and a method for manufacturing a film comprising same, and, more specifically, to: a three-dimensional structure for carrying a cell culture medium, comprising both a three-dimensional structure capable of carrying the proteins of a cell culture medium, and a microporous structure capable of carrying functional materials; and a method for manufacturing a film comprising same. | 2022-07-21 |
20220228096 | Cell Scaffold Material, Cell Culture Support, and Cell Culture Method - A cell scaffold material comprising a copolymer having a polylactic acid structural unit (A) and a polycarbonate structural unit (B). The polycarbonate structural unit (B) may include at least one unit having an alkoxyalkyloxycarbonyl group as a substituent. Also provided is a cell culture support comprising this cell scaffold material and a substrate. | 2022-07-21 |
20220228097 | MODULAR, CONFIGURABLE BIOREACTOR SYSTEM FOR A MANUFACTURING LINE - A configurable system for repeatably performing processes related to tissue growth in a controlled environment, possibly part of an industrial production line. The system can accommodate various sizes and shapes of culture vessels, and can maintain the cells at a desired temperature in the culture vessels, thus enabling a plug and play system that can produce consistent and repeatable results. The system includes gas management, fluid management, and control of multiple processes simultaneously, and can be automatically operably coupled with a variety of supporting technologies that can enable tissue-related processes. The system can communicate with supporting technologies upstream and downstream on a manufacturing line, enabling fully automated process control, centralized data historization, and centralized control. | 2022-07-21 |
20220228098 | TANGENTIAL FLOW DEPTH FILTRATION SYSTEMS AND METHODS OF FILTRATION USING SAME - The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same. | 2022-07-21 |
20220228099 | INCUBATOR SHAKER WITH OZONE DECONTAMINATION AND METHOD FOR DECONTAMINATING AN INCUBATOR SHAKER - Disclosed is an incubator shaker ( | 2022-07-21 |
20220228100 | PORTABLE DISPOSABLE RE-USABLE CULTURE DEVICE FOR RAPID DIAGNOSIS OF INFECTIOUS AGENTS - The present invention is directed to compositions, tools, methods and devices to culture microorganisms and, in particular, to compositions, tools, methods and devices for the detection of microorganisms in biological samples. | 2022-07-21 |
20220228101 | AUTOMATED T CELL CULTURE - An automated method of T cell scale down processing. The method including: activating T cells by automatically contacting the T cells with one or more activation reagents; transducing the T cells by automatically contacting the T cells with a recombinant viral vector; automatically inoculating T cells; automatically expanding the T cells; optionally, automatically debeading the T cells; and automatically harvesting the T cells. A system for an automated method of T cell scale down processing. | 2022-07-21 |
20220228102 | DATA-DRIVEN PREDICTIVE MODELING FOR CELL LINE SELECTION IN BIOPHARMACEUTICAL PRODUCTION - A method for facilitating selection of cell lines to advance to a next stage of cell line screening includes receiving first attribute values for the candidate cell lines measured using an opto-electronic cell line generation and analysis system, and acquiring second attribute values that include one or more attribute values measured at a cell pool screening stage of the candidate cell lines. The method also includes determining a ranking of the candidate cell lines according to a product quality attribute associated with hypothetical small-scale screening cultures. Determining the ranking includes predicting, for each of the candidate cell lines, a value of the product quality attribute by analyzing the first and second plurality of attribute values using a machine learning based regression estimator, and comparing the predicted values. The method also includes causing an indication of the ranking to be presented to a user via a user interface. | 2022-07-21 |
20220228103 | PRODUCING METHOD OF STRESS RELIEVER - Provided is a method of producing a stress reliever that reduces a decrease in productivity of livestock at the time of stress load by feeding the stress reliever to the livestock. The method of producing the stress reliever includes solid-culturing a substrate with the filamentous bacteria, in which the stress reliever reduces a decrease in productivity of livestock at the time of stress load. | 2022-07-21 |
20220228104 | ENGINEERED ORGANISMS AND USES THEREOF AS LIVING MEDICINES, RESEARCH TOOLS, FOOD PRODUCTS, OR ENVIRONMENTAL TOOLS - Provided herein are engineered organism containing a transgene in which expression of the transgene in an open environment is prevented or reduced, for example, by recoding designs. Also provided are methods of producing such engineered organism and use of such engineered organisms as therapeutics or for producing food, food supplement, and animal feed products. | 2022-07-21 |
20220228105 | BACTERIUM COMPRISING MYO-INOSITOL TO PROPIONATE PATHWAY - The invention is concerned with a bacterium comprising a inositol to propionic acid pathway gene set that allows said bacterium to convert inositol to propionic acid or a salt or ester thereof. The bacterium can be used as a probiotic or supplement to promote production of propionic acid in the GI tract, thereby preventing and/or treating conditions or diseases that benefit from the production of propionic acid, for example metabolic disease, metabolic syndrome, insulin resistance or insulin resistance-related conditions, particularly dyslipidemia, type 2 diabetes mellitus and insulin-resistance in endocrine diseases. | 2022-07-21 |
20220228106 | Strain of Lactobacillus rhamnosus and Application thereof in Inhibiting Helicobacter pylori - The disclosure discloses a strain of | 2022-07-21 |
20220228107 | METHODS OF IMPROVING PROTEIN TITER IN CELL CULTURE - Methods of improving recombinant protein titer and cell titer in cell culture using cell culture media having reduced impurities are provided, and well as cell culture media having reduced impurities that can used for the production of a recombinant protein and cells with improved titer. The cell culture media having reduced impurities comprises a HEPES buffer, and the reduced impurities are HEPES related impurities. In certain aspects, methods and media improve protein titer, cell growth, and/or viable cell density. | 2022-07-21 |
20220228108 | CELL CULTURE BASE MATERIAL AND CELL CULTURE BASE MATERIAL WITH CELLS - There is provided a cell culture base material having a porous membrane having an opening ratio of 30% to 70% and an extracellular matrix with which an inside of a hole of the porous membrane is filled. There is also provided a cell culture base material with cells having a cell layer on at least one surface of the cell culture base material. | 2022-07-21 |
20220228109 | INJECTABLE OFF-THE- SHELF CARTILAGE, TENDON, AND LIGAMENT REPAIR COMPOSITIONS AND METHODS OF USE - Compositions comprising a condensed mesenchymal cell body and a hydrogel are provided. The compositions may further include drugs or growth factors. The condensed mesenchymal cell body may include a connective tissue cell, or even a progenitor cell capable of producing connective tissue extracellular matrices such collagen and glycosaminoglycan. Also provided are methods of treating connective tissue defects, cartilage injury, and cartilage degradation. | 2022-07-21 |
20220228110 | EXPRESSION VECTORS, METHODS FOR SCREENING HOST CELLS EXPRESSING TARGET PROTEINS, AND METHODS FOR ESTABLISHING CELL LINES STABLY EXPRESSING FOREIGN RECOMBINANT GENES - A method for screening host cells expressing a target protein is provided. The method includes the following steps: providing an expression vector, the expression vector including a promoter, a gene encoding a target protein and an FTH1 gene; transfecting the host cells with the expression vector; culturing the host cells in a medium; and adding iron ions to the medium, and screening the surviving host cells to obtain the host cells expressing the target protein. An expression vector and a method for establishing a cell line stably expressing an exogenous recombinant gene are also provided. | 2022-07-21 |
20220228111 | NOCICEPTOR DIFFERENTIATION FROM HUMAN PLURIPOTENT STEM CELLS - Methods for Generating Neural Crest-Like Cells and Nociceptor-Like Cells from Human Pluripotent Stem Cells are Provided Along with the Related Compositions. | 2022-07-21 |
20220228112 | MEDIUM FOR CULTURING HEPATOCYTE, METHOD OF PRODUCING HEPATOCYTE, AND HEPATOCYTE - An object of the present invention is to provide a medium with which hepatocytes can be cultured while a metabolic function thereof is maintained, a method of producing a hepatocyte using the above medium, and the hepatocyte that is obtained by the above method. According to the present invention, there is provided a medium for culturing a hepatocyte, containing one or more of a ROCK inhibitor, nicotinamide, and an analogous substance of the nicotinamide, in which a content of a serum component is less than 5% by volume, a content of an EGF receptor activating factor is less than 1 ng/mL, and a content of an ALK inhibitor is less than 0.1 μmol/L. | 2022-07-21 |
20220228113 | Hair Follicle Primordia and Method for Producing Same - Provided is a hair follicle germ capable of forming a hair shaft-like structure in vitro simply and within a short period of time. A method of producing a hair follicle germ includes: inoculating epithelial cells and mesenchymal cells; maintaining the epithelial cells and the mesenchymal cells in a culture solution in which (a) laminin and entactin, and/or (b) type IV collagen is dispersed; and co-culturing the epithelial cells and the mesenchymal cells in a culture solution to form a hair follicle germ. | 2022-07-21 |
20220228114 | THERAPEUTIC T-CELLS WITH MODIFIED EXPRESSION OF T-BET, EOMES, AND c-MYB TRANSCRIPTION FACTORS - Disclosed herein are recombinant immune effector cells genetically modified to regulate expression of one or more transcription factors selected from T-bet, Eomes, and c-Myb. In some embodiments, the cells are modified to express recombinant T-bet, Eomes, c-Myb, or any combination thereof. In some embodiments, the cells are modified to express recombinant dominant negative forms of T-bet, Eomes, c-Myb, or any combination thereof to inhibit the activity of endogenous transcription factors. In some embodiments combinations of these approaches are used to increase expression of one or more of T-bet, Eomes, c-Myb while inhibiting the activity of one or more of T-bet, Eomes, and c-Myb. | 2022-07-21 |
20220228115 | NUCLEIC ACID MOLECULES ENCODING AN ENGINEERED ANTIGEN RECEPTOR AND AN INHIBITORY NUCLEIC ACID MOLECULE AND METHODS OF USE THEREOF - The present disclosure provides nucleic acid molecules encoding an engineered antigen receptor, such as a chimeric antigen receptor or exogenous T cell receptor, and an inhibitory nucleic acid molecule, such as an RNA interference molecule. The present disclosure further relates to nucleic acids, DNA constructs, vectors, pharmaceutical compositions, genetically-modified cells, and methods of treatment that utilize the nucleic acid molecules of the invention. | 2022-07-21 |
20220228116 | CD8+ T-CELLS LACKING PLEXINS AND THEIR APPLICATION IN CANCER TREATMENT - The invention relates to field of cancer therapy. In particular, it relates to (populations of) isolated CD8+ T-cells substantially lacking functional plexin-A2 and/or plexin-A4. Such cells can be employed in e.g. adoptive cell transfer to treat a tumor or cancer. | 2022-07-21 |
20220228117 | METHODS OF PRODUCING MODIFIED NATURAL KILLER CELLS AND METHODS OF USE - Disclosed herein are method of producing NK cells that include one or more heterologous nucleic acids. The methods include culturing a population of isolated NK cells in the presence of one or more cytokines to produce a population of activated NK cells. The population of activated NK cells are transduced with a viral vector comprising the one or more heterologous nucleic acids, for example by contacting the activated NK cells with viral particles including the viral vector. The resulting transduced NK cells are then cultured in the presence of one or more cytokines, and optionally in the presence of irradiated feeder cells, to produce a population of expanded transduced NK cells. Also disclosed are methods of treating a subject with a disorder (such as a tumor or hyperproliferative disorder) by administering to the subject NK cells produced by the methods described herein. | 2022-07-21 |
20220228118 | METHODS AND MATERIALS FOR HEMATOENDOTHELIAL DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS UNDER DEFINED CONDITIONS - Methods, kits and compositions for differentiating pluripotent stem cells into cells of endothelial and hematopoietic lineages are disclosed. | 2022-07-21 |
20220228119 | BROWN ADIPOCYTE PROGENITORS IN HUMAN SKELETAL MUSCLE - This invention relates to brown adipose tissue (BAT) progenitor cells and methods for isolating BAT progenitor cells from skeletal muscle. BAT progenitor cell surface markers and medium and agents for inducing cell differentiation into brown adipocytes are also provided. In some embodiments, the BAT progenitor cell expresses a first cell surface marker associated with endothelial cells, the first cell surface marker being detectable in an antibody based assay using a first antibody. In addition, the BAT progenitor cell can be substantially free of a second cell surface marker associated with endothelial cells, the second cell surface marker being substantially undetectable in said antibody based assay using a second antibody. The BAT progenitor cell can also be substantially free of additional cell surface markers. | 2022-07-21 |
20220228120 | Cardiomyocyte Compositions and Use Thereof - Provided herein are enriched populations of ventricular compact cardiomyocytes and enriched populations of mature ventricular or atrial cardiomyocytes, as well as methods of generating the enriched cell populations and methods of using the enriched cell populations in regenerative cardiac cell therapies. | 2022-07-21 |
20220228121 | CULTURED MEAT PRODUCT WITH GENETICALLY MODIFIED CELLS - Provided herein are genetically engineered mammalian cells that endogenously express one or more phytochemicals, vitamins, or therapeutic agents and suitable for use in a cultured meat product. Methods of making and using the genetically engineered mammalian cells and the cultured meat products are also provided. | 2022-07-21 |
20220228122 | METHODS OF ISOLATION AND USE OF CD39 STROMAL STEM CELLS - Disclosed herein are methods of isolating SDC2+ stromal stem cells and exosomes from SDC2+ stromal stem cells by expression of surface marker CD39. Also disclosed herein are stromal stem cells and exosomes isolated by said methods. | 2022-07-21 |
20220228123 | METHODS OF DIFFERENTIATING STEM CELL-DERIVED ECTODERMAL LINEAGE PRECURSORS - The presently disclosed subject matter provides for in vitro methods of inducing differentiation of human stem cells into neural crest, cranial placode or non-neuro ectoderm precursors, and cells generated by such methods. The presently disclosed subject matter also provides for uses of such cells for treating neurodegenerative and pituitary disorders. | 2022-07-21 |
20220228124 | Three-Dimensional Cross-Linked Scaffolds Of Peripheral Blood Plasma And Their Use - The disclosure provides three-dimensional cross-linked scaffolds generated from peripheral blood plasma, and methods for making and using such scaffolds. | 2022-07-21 |
20220228125 | REPROGRAMMING METHODS AND CELL CULTURE PLATFORMS - The invention provides compositions and methods for manufacturing pluripotent cells. In particular, the invention provides improved culture platforms for manufacturing pluripotent cells with ground state pluripotency. In various embodiments, the invention contemplates, in part, a composition comprising: (a) a Wnt pathway agonist; (b) a MEK inhibitor; and (c) a ROCK inhibitor. In certain embodiments, the composition further comprises bFGF or LIF. | 2022-07-21 |
20220228126 | USE OF PCBP1 TO GENERATE INDUCED PLURIPOTENT STEM CELLS WHILE INHIBITING ONCOGENESIS - The present disclosure provides compositions and methods of using gene therapy to create induced pluripotent stem cells (iPSCs) without inducing cancer or tumorigenesis. The methods disclosed herein employ plasmids and vectors that contain transcription factors and an anti-oncogene such as PCBP1 which inhibits the expression of cancer biomarkers and concomitant oncogenesis. | 2022-07-21 |
20220228127 | RESIN FILM FORMED BY SCAFFOLD MATERIAL FOR CELL CULTURE AND CONTAINER FOR CELL CULTURE - Provided is a resin film having excellent cell extensibility in cell culture. The resin film formed of a scaffold material for cell culture containing a synthetic resin, the resin film having a compressive modulus of 5.5 GPa or more at a frequency of 1 Hz as measured using a nanoindenter device in ion-exchanged water in accordance with ISO14577-1 after being immersed in the ion-exchanged water at 37° C. for 24 hours. | 2022-07-21 |
20220228128 | USE OF POXVIRUS WITH AUTOLOGOUS INDUCED PLURIPOTENT STEM CELLS FOR VACCINATION AND DISEASE THERAPY - Provided herein are compositions of induced pluripotent stem cells (iPSCs), or pancreatic beta cells, and poxvirus, and methods of making and using the same to treat disease. | 2022-07-21 |
20220228129 | CELLS FOR ENHANCED PRODUCTION OF ADENO-ASSOCIATED VIRUS - The present disclosure provides an in vitro mammalian cell that is genetically modified to provide for enhanced production of adeno-associated virus (AAV) virions. The mammalian cells can be used to produce AAV virions, e.g., recombinant AAV virions that include a heterologous nucleic acid encoding a gene product; the present disclosure thus provides methods for producing an AAV virion, which may be a recombinant AAV virion. | 2022-07-21 |
20220228130 | OPTIMIZED CANNABINOID SYNTHASE POLYPEPTIDES - The present disclosure provides engineered variants of a cannabidiolic acid synthase (CBDAS) polypeptide comprising an amino acid sequence of SEQ ID NO:3 with one or more amino acid substitutions, nucleic acids comprising nucleotide sequences encoding said engineered variants, methods of making modified host cells comprising said nucleic acids, modified host cells expressing said engineered variants, methods of producing cannabinoids or cannabinoid derivatives, and methods of screening engineered variants of the cannabidiolic acid synthase (CBDAS) polypeptide. | 2022-07-21 |
20220228131 | METHODS AND COMPOSITIONS FOR PRODUCING VITAMIN K DEPENDENT PROTEINS - The present invention relates to methods and compositions for improving the productivity of recombinant vitamin K dependent protein expression in host cells. | 2022-07-21 |
20220228132 | UNSPECIFIC PEROXYGENASE ENZYME VARIANTS FOR SELECTIVE FATTY ACID EPOXIDATION OR HYDROXYLATION - The invention relates to a recombinant | 2022-07-21 |
20220228133 | SINGLE BASE SUBSTITUTION PROTEIN, AND COMPOSITION COMPRISING SAME - The present application relates to: a single base substitution protein; a composition comprising same; and a use thereof. | 2022-07-21 |
20220228134 | DNA-CUTTING AGENT BASED ON CAS9 PROTEIN FROM THE BACTERIUM PASTEURELLA PNEUMOTROPICA - The present invention describes a novel bacterial nuclease of a CRISPR-Cas9 system from the bacterium | 2022-07-21 |
20220228135 | CHIMERIC ENDOLYSIN LYS109 WITH ANTIMICROBIAL ACTIVITY AGAINST STAPHYLOCOCCUS AUREUS - The present invention relates to chimeric endolysin Lys109 which effectively controls | 2022-07-21 |
20220228136 | PROCESS AND SYSTEM FOR OBTAINING BOTULINUM NEUROTOXIN - Rapid, animal protein free, chromatographic processes and systems for obtaining high potency, high yield | 2022-07-21 |
20220228137 | METHOD, COMPOSITION AND KIT FOR SIZE SELECTIVE ENRICHMENT OF NUCLEIC ACIDS - Provided is a method for isolating and concentrating nucleic acids of selected target sizes (e.g., in increments less than 1000 base pairs) from a biological fluid mixture comprising combining the biological fluid mixture and a first aqueous two-phase system (ATPS) formed from a first phase forming polymer or surfactant component dissolved in a first phase solution, and a second phase solution, such that target nucleic acid fragments below a desired target size partition to said second phase solution and contaminants partition to the first phase solution, extracting and mixing the second phase solution with a second ATPS formed from a second phase forming polymer or surfactant component dissolved in a third phase solution and a fourth phase solution, such that the target nucleic acid fragments partition to and concentrate in the third phase solution, and recovering the concentrated target nucleic acid fragments from the third phase solution. A composition and kit for isolating and concentrating nucleic acids of selected target sizes as described above are also provided. | 2022-07-21 |
20220228138 | METHOD FOR PREPARING PHAGE LIBRARY - Provided is method for producing a phage library displaying antibodies or antibody fragments, comprising providing a first polynucleotide containing LC, a second polynucleotide containing connexon, and a third polynucleotide containing HC, respectively introducing the first, second and third polynucleotides to first, second and third bacteria to obtain a light chain component bacterial library, a connexon component bacterial library, and a heavy chain component bacterial library, obtaining a light chain component plasmid, a connexon component plasmid, and a heavy chain component plasmid from the libraries, obtaining the released LC, released connexon and released HC from the plasmids, connecting the released display vector segments to form a connection product for display, introducing a third bacterium to obtain a display bacterial library, and using the display bacterial library to prepare the phage library for displaying the antibodies or antibody fragments. Also provided is a phage library produced according to the method. | 2022-07-21 |
20220228139 | METHOD FOR AMPLIFYING AND DETECTING RIBONUCLEIC ACID (RNA) FRAGMENTS - The present invention relates to a method for amplifying and detecting ribonucleic acid (RNA) fragments. In particular, the method of the present invention comprises conversion of RNA fragments to cDNA and DNA amplification. The present invention also provides a kit for performing the method as described herein. | 2022-07-21 |
20220228140 | COMPOUND, METHOD AND PHARMACEUTICAL COMPOSITION FOR MODULATING EXPRESSION OF DUX4 - An object of the present invention is to provide a compound, a method and a pharmaceutical composition for normalizing double homeobox 4 (DUX4) of an individual in which the DUX4 gene has abnormally expressed. Provided is a modified oligonucleotide consisting of 12-30 residues. The modified oligonucleotide includes a nucleobase sequence that includes at least 8 contiguous nucleobase sequences and is complementary to an equal length portion at positions 126-147, 232-248, 1306-1325 or 1472-1495 from a 5′ end of a nucleobase of a mature mRNA of DUX4 of SEQ ID NO: 1. The nucleobase sequence of the modified oligonucleotide has at least 90% complementarity to the equal length portion in the nucleobase sequence of the mature mRNA of DUX4 of SEQ ID NO: 1. | 2022-07-21 |
20220228141 | OLIGONUCLEOTIDES FOR DGAT2 MODULATION - This disclosure relates to novel DGAT2 targeting sequences. Novel DGAT2 targeting oligonucleotides for the treatment of non-alcoholic fatty liver disease (NAFLD) and lipodystrophy syndromes (or metabolic syndrome) are also provided. | 2022-07-21 |
20220228142 | COMPOSITIONS AND METHODS FOR EDITING BETA-GLOBIN FOR TREATMENT OF HEMAGLOBINOPATHIES - The disclosure features systems and methods for correcting a mutation in the human beta-globin (HBB) gene in a cell or population of cells. The disclosure also features methods of increasing repair of a DNA double stranded break (DSB) in an HBB gene by the homology-directed repair (HDR) pathway. The disclosure also features compositions for use in the methods. | 2022-07-21 |
20220228143 | MICRORNAS FOR CARDIAC REGENERATION THROUGH INDUCTION OF CARDIAC MYOCYTE PROLIFERATION - The present invention discloses a set of human microRNAs, or a primary transcript for such microRNAs, or a precursor of such microRNAs or a mimic of such MicroRNAs or a combination thereof and their use as medicaments for inducing proliferation of cardiomyocytes for the prevention and treatment of heart, diseases associated with a loss of cardiomyocytes. The invention also relates to a method for screening microRNAs and biological and therapeutically active compounds for their ability to increase proliferation of cardiomyocytes. | 2022-07-21 |
20220228144 | SERPIN FAMILY F MEMBER 2 (SERPINF2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF - The present invention relates to RNAi agents, e.g., double stranded RNA (dsRNA) agents, targeting the SERPINF2 gene. The invention also relates to methods of using such RNAi agents to inhibit expression of a SERPINF2 gene and to methods of preventing and treating a SERPINF2-associated disorder, e.g., a disorder associated with thrombosis. | 2022-07-21 |
20220228145 | A Ribozyme Comprising a Target-Binding Domain - A ribozyme comprising a target-binding domain, a polynucleotide encoding the same, a kit comprising the same, and uses thereof. | 2022-07-21 |
20220228146 | MICRO-RNA SITE BLOCKING OLIGONUCLEOTIDES FOR THE TREATMENT OF EPILEPTIC ENCEPHALOPATHY AND NEURODEVELOPMENTAL DISORDERS - Disclosed herein are compounds and methods for modulating expression of disease-causing genes such as STXBP1, SCN1A, SCN2A, SCN8A, SLC6A1, and MECP2. Such compounds and methods are useful to treat, prevent, or ameliorate epileptic encephalopathy and neurodevelopmental disorders in an individual in need thereof. | 2022-07-21 |
20220228147 | USES OF TREM COMPOSITIONS TO MODULATE TRNA POOLS - The invention relates generally to uses of tRNA-based effector molecules (TREMs) and methods of making the same. | 2022-07-21 |
20220228148 | EUKARYOTIC SEMI-SYNTHETIC ORGANISMS - Provided herein are eukaryotic semi-synthetic organisms and their methods of use and manufacture. | 2022-07-21 |
20220228149 | METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF ALPHA-1 ANTITRYPSIN BY DOUBLE-STRANDED RNA - This invention relates to compounds, compositions, and methods useful for reducing α-1 antitrypsin target RNA and protein levels via use of dsRNAs, e.g., Dicer substrate siRNA (DsiRNA) agents. | 2022-07-21 |
20220228150 | CRISPR SYSTEM HIGH THROUGHPUT DIAGNOSTIC SYSTEMS AND METHODS - High throughput methods utilizing spatially segregated detection systems provide a robust CRISPR-based diagnostic enabling highly sensitive detection of both DNA and RNA target molecules, with applications in multiple scenarios in human health including, for example, viral detection. Kits comprising the systems allow for point-of care applications with high-throughput processing of samples. | 2022-07-21 |
20220228151 | Carboxypeptidase B2 (CPB2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF - The present invention relates to RNAi agents, e.g., double stranded RNA (dsRNA) agents, targeting the CPB2 gene. The invention also relates to methods of using such RNAi agents to inhibit expression of a CPB2 gene and to methods of preventing and treating a CPB2-associated disorder, e.g., a disorder associated with thrombosis. | 2022-07-21 |
20220228152 | OLIGONUCLEOTIDE THERAPY FOR WOLMAN DISEASE AND CHOLESTERYL ESTER STORAGE DISEASE - The present disclosure provides antisense oligonucleotides, compositions, and methods that target a LIPA intron flanking exon 8, thereby modulating splicing of LIPA pre-mRNA to increase the level of LIPA mRNA molecules having exon 8, e.g., to provide a therapy for Wolman Disease or Cholesteryl Ester Storage Disease. The present disclosure provides an antisense oligonucleotide including a nucleobase sequence at least 70% complementary to a LIPA pre-mRNA target sequence in a 5′-flanking intron, a 3′-flanking intron, or a combination of exon 8 and the 5′-flanking or 3′-flanking intron. | 2022-07-21 |
20220228153 | COMPOSITIONS AND METHODS FOR CD33 MODIFICATION - Some aspects of this disclosure provides, e.g., novel cells having a modification (e.g., insertion or deletion) in the endogenous CD33 gene. Some aspects of the disclosure provide compositions, e.g., gRNAs, that can be used to make such a modification. | 2022-07-21 |
20220228154 | Methods for Screening Bacteria, Archaea, Algae, and Yeast Using CRISPR Nucleic Acids - This invention relates to the use of CRISPR nucleic acids to screen for essential and non-essential genes and expendable genomic islands in bacteria, archaea, algae and/or yeast, to kill bacteria, archaea, algae and/or yeast, to identify the phenotype of a gene or genes, and/or to screen for reduced genome size and/or a gene deletion in bacteria, archaea, algae and/or yeast. | 2022-07-21 |
20220228155 | NR4A SUPER-REPRESSORS AND METHODS OF USE THEREOF - The present disclosure provides super-repressors capable of inhibiting the transcription of NR4A1, NR4A2, and NR4A3 target genes. The super-repressors can be used to enhance the effector functions of immune cells, e.g., for adoptive cell therapy. Methods of treating disorders using the modified immune cells are also provided. | 2022-07-21 |
20220228156 | Gold Optimized CAR T-cells - Control Devices are disclosed including RNA destabilizing elements (RDE), RNA control devices, and destabilizing elements (DE) combined with Chimeric Antigen Receptors (CARs) or other transgenes in eukaryotic cells. Multicistronic vectors are also disclosed for use in engineering host eukaryotic cells with the CARs and transgenes under the control of the control devices. These control devices can be used to optimize expression of CARs in the eukaryotic cells so that, for example, effector function is optimized. CARs and transgene payloads can also be engineered into eukaryotic cells so that the transgene payload is expressed and delivered after stimulation of the CAR on the eukaryotic cell. | 2022-07-21 |
20220228157 | GENE EDITING IN DIVERSE BACTERIA - Provided herein, in some aspects are high efficiency gene editing methods in bacterial cells using single-stranded annealing proteins and/or single-stranded binding proteins. | 2022-07-21 |
20220228158 | INDIGO PLANT POPULATIONS WITH HIGH INDICAN CONTENT - According to the invention, there is provided a novel population of indigo plants ( | 2022-07-21 |
20220228159 | GENETIC LOCUS FOR REGULATING THCAS ACTIVITY IN CANNABIS SATIVA L. - Isolated nucleic acids containing polymorphisms associated with low THCA content have been identified in | 2022-07-21 |
20220228160 | OLEIC ACID -ENRICHED PLANT BODY HAVING GENETICALLY MODIFIED FAD2 AND PRODUCTION METHOD THEREOF - The present invention relates to an artificially manipulated unsaturated fatty acid biosynthesis-associated factor and use thereof to increase the content of a specific unsaturated fatty acid of a plant body. More particularly, the present invention relates to a system capable of artificially controlling unsaturated fatty acid biosynthesis and a plant body produced thereby, which include an artificially manipulated unsaturated fatty acid biosynthesis-associated factor to control unsaturated fatty acid biosynthesis and a composition capable of artificially manipulating the factor. In a specific aspect, the present invention relates to artificially manipulated unsaturated fatty acid biosynthesis-associated factors such as FAD2, FAD3, FADE, FAD7 and FAD8 and/or an unsaturated fatty acid biosynthesis controlling system by an expression product thereof. | 2022-07-21 |
20220228161 | PLANT SERINE PROTEASES - The present invention relates to a genetically modified plant or plant cell derived from a wild-type plant or plant cell, said wild-type plant or plant cell producing at least one serine protease comprising the motif SSRGPX | 2022-07-21 |
20220228162 | Powdery Mildew Resistant Rose - Provided herein are rose plants such as cut roses, garden roses and pot roses having at least two genes providing resistance to a pathogen causing powdery mildew. Specifically, provided herein are rose plants resistant to the powdery mildew causing pathogen | 2022-07-21 |
20220228163 | DOWNY MILDEW RESISTANT MELON PLANTS - The present disclosure relates to melon plants that are resistant to the plant disease downy mildew caused by the pathogen | 2022-07-21 |
20220228164 | ENGINEERED ANTIGEN PRESENTING CELLS - Provided herein are various engineered antigen presenting cells, methods of making them and methods of using them. | 2022-07-21 |
20220228165 | DNA Construct for Diagnosing and Treating Cancer - The present disclosure relates to a DNA construct, and a strain into which a recombinant vector comprising the DNA construct has been introduced. The DNA construct according to the present disclosure allows the expression levels of genes, operably linked downstream of first and second promoters, in a host strain or cell, to be balanced, so that cancer diagnosis and treatment may be performed simultaneously. In addition, the DNA construct of the present disclosure completely does not allow the anticancer protein and the reporter protein to be expressed at all in the absence of doxycycline, and thus it allows the anticancer protein to be expressed at an appropriate dose for cancer treatment by controlling whether or not treatment with doxycycline is performed, and at the same time, enables the size of the cancer to be monitored in real time depending on the expression level of the reporter protein. | 2022-07-21 |