30th week of 2015 patent applcation highlights part 24 |
Patent application number | Title | Published |
20150203850 | METHODS OF TREATMENT USING TLR7 AND/OR TLR9 INHIBITORS - The application relates to compositions and methods of regulating an immune response comprising inhibitors of TLR7 and/or TLR9, such as immunoregulatory polynucleotides and/or immunoregulatory compounds. The application also relates to compositions and methods for predicting and/or determining responsiveness of a disease to treatment comprising inhibitors of TLR7 and/or TLR9. | 2015-07-23 |
20150203851 | INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN PCAF FOR THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES OR FOR THE TREATMENT OF CANCER - A method of treating autoimmune and inflammatory diseases or conditions or cancer in a mammal, such as a human, which comprises the administration of an inhibitor of the bromodomain-containing protein PCAF. | 2015-07-23 |
20150203852 | INHIBITION OF OXIDATIVE STRESS IN ATRIAL FIBRILLATION - Disclosed herein are pharmaceutical compositions and methods for inhibiting oxidative stress in a subject having atrial or ventricular arrhythmias, ventricular failure or heart failure. The methods include administering an effective amount of a NOX2 inhibitor agent to the subject, wherein said administering is under conditions such that a level of oxidative stress in myocardial tissue is reduced or eliminated. The pharmaceutical compositions include a NOX2 inhibitor agent. | 2015-07-23 |
20150203853 | PLASMID VECTOR, METHOD FOR DETECTING GENE PROMOTER ACTIVITY, AND ASSAY KIT - According to one embodiment, a first gene encodes a reporter protein. The first gene is disposed at the downstream of the gene promoter. A second gene is disposed at the downstream of the gene promoter and encodes a replication origin-binding protein. An internal ribosome entry site is disposed between the first gene and the second gene. The transcription termination signal sequence encodes a signal for terminating the transcription of the first gene and the second gene. A replication origin sequence is recognized by the replication origin-binding protein. | 2015-07-23 |
20150203854 | E. COLI PLASMID DNA PRODUCTION - General methods and strains of bacteria are described that dramatically simplify and streamline plasmid DNA production. In one preferred embodiment, endolysin mediated plasmid extraction combined with flocculation mediated removal of cell debris and host nucleic acids achieves increased yield and purity with simplified downstream purification and reduced waste streams, thus reducing production costs. | 2015-07-23 |
20150203855 | ASPERGILLUS MUTANT STRAIN | 2015-07-23 |
20150203856 | USE OF A MAIZE UNTRANSLATED REGION FOR TRANSGENE EXPRESSION IN PLANTS - Provided are methods, vectors and gene constructs for enhancing expression of a recombinant nucleic acid sequence in transgenic plants and plant tissues. According to the present invention, nucleic acid sequences are obtained and/or derived from the 3′ untranslated regions of genes encoding ubiquitin proteins and engineered to flank respective portions of a selected coding region of a vector. The vector construct may be introduced into plants and/or plant tissues through conventional or gene targeting procedures, resulting in enhanced expression of the selected coding region. In some embodiments, the selected coding region is a chimeric gene or gene fragment expressing one or more proteins known to impart a level of insecticidal activity to a transgenic plant and/or plant tissue. | 2015-07-23 |
20150203857 | INCREASED PROTEIN EXPRESSION IN PLANTS - This disclosure concerns synthetic polynucleotides encoding a polypeptide of interest that are particularly well-suited for expression in target plants. | 2015-07-23 |
20150203858 | PRODUCTION OF PLANTS WITH DECREASED NITRITE CONTENT - The present invention relates in one aspect to a method for producing a transgenic plant, comprising introducing into an unmodified plant an exogenous gene encoding a nitrite reductase, wherein expression of the nitrite reductase encoded by the exogenous gene reduces nitrite content in the transgenic plant relative to the unmodified plant. Also provided are transgenic plants and plant cells comprising an exogenous gene encoding a nitrite reductase, as well as associated uses, chimaeric genes and plant transformation vectors. | 2015-07-23 |
20150203859 | NUCLEIC ACID SEQUENCES ENCODING TRANSCRIPTION FACTORS REGULATING ALKALOID BIOSYNTHESIS AND THEIR USE IN MODIFYING PLANT METABOLISM - Plant metabolism and alkaloid levels can be regulated by transcription factors that regulate the nicotinic alkaloid biosynthetic pathway. In one embodiment, the disclosure provides a transcription factor that negatively regulates alkaloid biosynthesis, such as nicotine biosynthesis. | 2015-07-23 |
20150203860 | METHODS FOR INCREASING STARCH CONTENT IN PLANTS - Methods and compositions for increasing the starch content in green tissues of a plant are provided. The method comprises down-regulating me activity of starch degradation enzymes in a plant. The resulting transgenic plants of the invention have increased starch content in green tissues and exhibit a starch excess phenotype. In one embodiment the method involves manipulating a monocot plant to down-regulate the activity of a starch degradation enzyme. The plants are useful for improving the yield of free sugars from plant biomass and increase dried green tissue storage stability. | 2015-07-23 |
20150203861 | Increased Caloric and Nutritional Content of Plant Biomass - As described herein, plants expressing algal Diacylglycerol Acyltransferase Type Two (DGTT) from heterologous nucleic acids can alter acyl carbon partitioning in plant vegetative tissues and increase acyl-CoA-dependent triacylglycerol synthesis, thereby increasing the lipid content of the plants' tissues. | 2015-07-23 |
20150203862 | NOVEL GLYCOSYLTRANSFERASE GENE AND USE THEREOF - A polynucleotide is provided that encodes a protein having activity that transfers a sugar to the hydroxyl group at the 4′-position of a flavone. The polynucleotide is selected from the group consisting of: (a) a polynucleotide composed of the base sequence of SEQ ID NO: 1; (b) a polynucleotide that hybridizes under stringent conditions with a polynucleotide composed of a base sequence complementary to the base sequence of SEQ ID NO: 1, and encodes a protein having activity that transfers a sugar to the hydroxyl group at the 4′-position of a flavone; (c) a polynucleotide encoding a protein composed of the amino acid sequence of SEQ ID NO: 2; and, (d) a polynucleotide encoding a protein composed of an amino acid sequence in which one or a plurality of amino acids have been deleted, substituted, inserted and/or added in the amino acid sequence of SEQ ID NO: 2, and having activity that transfers a sugar to the hydroxyl group at the 4′-position of a flavone. | 2015-07-23 |
20150203863 | GENETIC ENGINEERING METHOD AND MATERIAL FOR INCREASING PLANT YIELD - A method includes increasing EXPA1 gene expression or increasing the activity of EXPA1 polypeptide to produce a plant with an improved trait. The method may further include increasing the expression of RDL1 gene or the activity of RDL1 kpolypeptide. expression of GhRDL1 and GhEXPA1 Co-expression of EXPA1 and RDL genes can improve plant traits. These methods have applications in crops and flower productions. | 2015-07-23 |
20150203864 | MYB55 PROMOTER AND USE THEREOF - The invention provides MYB55 promoter sequences that can advantageously be used to express a nucleotide sequence of interest in a plant, plant part or plant cell. Also provided are methods of increasing the expression of a nucleotide sequence of interest in a plant, plant part or plant cell in response to high temperature, abscisic acid, salicylic acid and/or methyl jasmonate. Further provided are methods of increasing the tolerance of a plant, plant part or plant cell to heat stress using the promoter sequences as described herein. | 2015-07-23 |
20150203865 | RNAS FROM PATHOGENS INHIBIT PLANT IMMUNITY - The present invention relates to pathogen-resistant plants comprising a heterologous expression cassette, the expression cassette comprising a promoter operably linked to a polynucleotide that is complementary to, or mediates destruction, of a plant immunity suppressing sRNA of a pathogen, wherein the plant is less susceptible to the pathogen compared to a control plant lacking the expression cassette. Methods of making and cultivating pathogen-resistant plants are also provided. | 2015-07-23 |
20150203866 | METHODS AND COMPOSITIONS FOR PLANT PEST CONTROL - The present invention is directed to controlling nematode infestation. The invention discloses methods and compositions for use in controlling nematode infestation by providing recombinant DNA molecules to the cells of a plant in order to achieve a reduction in nematode infestation. The invention is also directed to methods for making transgenic plants that express the recombinant DNA molecule for use in protecting plants from nematode infestation. | 2015-07-23 |
20150203867 | Compositions and Methods for Controlling Leptinotarsa - Disclosed herein are methods of controlling insect pests, in particular | 2015-07-23 |
20150203868 | GENE THERAPY METHODS - The present invention generally provides improved gene therapy vectors, cell-based compositions, and methods of using the same in methods of gene therapy. The present invention further provides improved gene therapy compositions for expanding hematopoietic cells and related methods for treatment of diseases, disorders, and conditions of the hematopoietic system such as thalassemias and anemias. | 2015-07-23 |
20150203869 | Adenoviral Vectors for Transduction of Vascular Tissue - The invention relates to the field of gene transfer, and in particular to the use of adenoviral vectors of serotype Ad49 for gene delivery to vascular tissue. | 2015-07-23 |
20150203870 | METHODS AND COMPOSITIONS RELATING TO IMPROVED LENTIVIRAL VECTOR PRODUCTION SYSTEMS - The present invention provides HIV-derived lentivectors which are multiply modified to create highly safe, efficient, and potent vectors for expressing transgenes for gene therapy. The lentiviral vectors comprise various combinations of an inactive central polypurine tract, a stuffer sequence, which may encode drug susceptibility genes, and a mutated hairpin in the 5′ leader sequence that substantially abolishes replication. These elements are provided in conjunction with other features of lentiviral vectors, such as a self-inactivating configuration for biosafety and promoters such as the EF1α promoter as one example. Additional promoters are also described. The vectors can also comprise additional transcription enhancing elements such as the wood chuck hepatitis virus post-transcriptional regulatory element. These vectors therefore provide useful tools for genetic treatments for inherited and acquired disorders, gene-therapies for cancers and other disease, the creation of industrial and experimental production systems utilizing transformed cells, as well as for the study of basic cellular and genetic processes. | 2015-07-23 |
20150203871 | Transcription Activator-Like Effector (TALE) Fusion Protein - The present invention relates to Transcription Activator-Like Effector (TALE) derived proteins that allow to efficiently target and/or process double stranded nucleic acid sequences. The proteins of the invention are typically chimeric protein monomers composed of a core scaffold comprising Repeat Variable Dipeptide regions (RVDs) having binding specificity to a DNA target sequence, to which is fused a catalytic domain to its N-terminal. This later catalytic domain, which can be a monomer of a nuclease, is placed at this position to possibly interact with another catalytic domain fused to another TAL monomer, such that, when said monomers are binding to their respective target DNA sequences, both catalytic domains form a catalytic entity likely to process DNA in the proximity of these target sequences. This new TAL architecture makes it possible to target only one DNA strand, which is not the case, for instance, with classical TALEN architectures. The present invention also relates to vectors encoding such proteins and compositions or kits in which Transcription Activator-Like Effector (TALE) proteins of the present invention are used. | 2015-07-23 |
20150203872 | CRISPR-CAS SYSTEMS AND METHODS FOR ALTERING EXPRESSION OF GENE PRODUCTS - The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. | 2015-07-23 |
20150203873 | INCREASED ISOPRENE PRODUCTION USING THE ARCHAEAL LOWER MEVALONATE PATHWAY - The invention features methods for producing isoprene from cultured cells using a feedback-resistant mevalonate kinase polypeptide, such as an archaeal mevalonate kinase polypeptide. The resulting isoprene compositions may have increased yields and/or purity of isoprene. | 2015-07-23 |
20150203874 | METHOD AND DEVICE FOR CONTINUOUS DRY METHANATION - A device for continuous dry methanation in a fermenter having a closed tank having at least one compartment to ferment the slurry comprising at least 17% dry matter. An injector to inject pressurized gas close to the bottom of the compartment via at least one chimney that descends through the compartment. The injected gas rising through the slurry creates a convective movement in the slurry around the chimney to stir the matter at the bottom of the compartment. The tank can include a first compartment into which the slurry is introduced and a second compartment into which the hydrolyzed slurry flows after hydrolysis and acidogenesis in the first compartment. Methanogenesis takes place in the second compartment. | 2015-07-23 |
20150203875 | MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING 1.4-BUTANEDIOL RELATED THERETO - Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway (MMP) that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO. | 2015-07-23 |
20150203876 | RECOMBINANT BACTERIA COMPRISING NOVEL SUCROSE TRANSPORTERS - Recombinant bacteria capable of metabolizing sucrose are described. The recombinant bacteria comprise in their genome or on at least one recombinant construct, a novel nucleotide sequence encoding a polypeptide having sucrose transporter activity and a nucleotide sequence encoding a polypeptide having sucrose hydrolase activity. These nucleotide sequences are each operably linked to the same or a different promoter. Recombinant bacteria capable of metabolizing sucrose to produce glycerol and/or glycerol-derived products such as 1,3-propanediol and 3-hydroxypropionic acid are also described. | 2015-07-23 |
20150203877 | Yeast Cells Having Reductive TCA Pathway from Pyruvate to Succinate and Overexpressing an Exongenous NAD(P)+ Transhydrogenase Enzyme - Yeast cells having a reductive TCA pathway from pyruvate or phosphoenolpyruvate to succinate, and which include at least one exogenous gene overexpressing an enzyme in that pathway, further contain an exogenous transhydrogenase gene. | 2015-07-23 |
20150203878 | PHA-PRODUCING GENETICALLY ENGINEERED MICROORGANISMS - The present invention is directed at genetically engineered form of a naturally PHA producing microorganism, which has an increased number of copies, compared to the wild type microorganism, of at least one gene coding a polyhydroxyalkanoate (PHA) synthase, wherein said increased number of copies provides a balanced overproduction of said PHA synthase, and eventually causing the microorganism to overproduce medium- or long-chain-length PHAs in an amount of at least 1.2 times compared to the wild type after 24 h, wherein the reference condition for assessing the overproduction is modified MM medium containing 15 mM sodium octanoate. The production of PHAs in the microorganism can in addition be favourably influenced by the inactivation of genes encoding for proteins involved in the degradation of PHA, resulting in an even increased production of the microorganism of this compound without a decline in the PHA content over time. The inventive microorganisms are useful in the commercial production of PHAs. The present invention further relates to a method for the production of PHA. | 2015-07-23 |
20150203879 | Methods and Microorganisms for the Biological Synthesis of (S) -2-amino-6-hydroxypimelate, Hexamethylenediamine and 6-aminocaproate - A chemical having the formula (S) 2-amino-6-hydroxypimelate. (S)-2-amino-6-hydroxypimelate can be made using a method comprising culturing a cell comprising an exogenous nucleic acid sequence encoding an enzyme that catalyzes the substrate to product conversion of (S)-2-amino-6-oxopimelate to (S)-2-amino-6-hydroxypimelate and separating the (S)-2-amino-6-hydroxypimelate. The cell may be a recombinant microorganism for producing aminocaproic acid or hexamethylenediamine from (S)-2-amino-6-hydroxypimelate comprising at least one exogenous nucleic acid sequence that expresses at least one polypeptide with substrate preference for homolysine, and amino acid decarboxylase with substrate preference for alpha-aminopimelate. | 2015-07-23 |
20150203880 | CO-CULTURE BASED MODULAR ENGINEERING FOR THE BIOSYNTHESIS OF ISOPRENOIDS, AROMATICS AND AROMATIC-DERIVED COMPOUNDS - The invention relates to co-cultures and their use in the biosynthesis of functionalized taxanes, other isoprenoids, aromatics, and aromatic-derived compounds. | 2015-07-23 |
20150203881 | Method for Producing an L-Amino Acid Using a Bacterium of the Enterobacteriaceae Family - A method for producing an L-amino acid is described, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine, L-tryptophan, or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of a wild-type alcohol dehydrogenase encoded by the adhE gene or a mutant alcohol dehydrogenase which is resistant to aerobic inactivation. | 2015-07-23 |
20150203882 | POLYPEPTIDES HAVING OXIDOREDUCTASE ACTIVITY AND THEIR USES - The invention relates to a polypeptide having oxidoreductase activity which comprises the amino acid sequence set out in SEQ ID NO: 3 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 4, or a variant polypeptide thereof having 45% or more sequence identity with the sequence of SEQ ID NO: 3. The invention also relates to a process for the production of 2,5-furan-dicarboxylic acid (FDCA) or production of 5-hydroxymethyl-2-furancarboxylic acid (HMF acid). | 2015-07-23 |
20150203883 | BIOSYNTHETIC GENE CLUSTER FOR CHEJUENOLIDE OF MARINE MICROORGANISM HAHELLA CHEJUENSIS - The present invention relates to a biosynthetic gene cluster for a chejuenolide of the marine microorganism | 2015-07-23 |
20150203884 | METHODS AND MATERIALS FOR MAKING SIMVASTATIN AND RELATED COMPOUNDS - The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin. | 2015-07-23 |
20150203885 | PROCESS FOR ENZYMATIC HYDROLYSIS OF LIGNOCELLULOSIC MATERIAL AND FERMENTATION OF SUGARS - The invention relates to a process for the preparation of a fermentation product from ligno-cellulosic material, comprising the following steps:
| 2015-07-23 |
20150203886 | Method for Cloning T Cell Receptor - An object is to provide a TCR closing system that enables not only bias-free analysis of TCR repertoires, but also collection of antigen-specific TCR α/β cDNA pairs and evaluation of functions thereof. There is provided a method for producing a gene of T cell receptor (TCR) specific to an antigen A, which comprises 1) the step of stimulating a group of T cells including a T cell specific to an antigen A or one T cell specific to an antigen A under a condition effective for amplification of a TCR gene; 2) the step of identifying a T cell specific to an antigen A among the group of T cells including a T cell specific to the antigen A, and sorting one T cell specific to the antigen A into a vessel; and 3) the step of subjecting the one activated T cell specific to the antigen A in the vessel to PCR to amplify a gene of TCR specific to the antigen A. According to the present invention, a target TCR gene can be cloned within a shorter time compared with that repaired by the conventional methods, for example, about ten days. Further, according to the present invention, genes of TCR α chain and β chain can be highly efficiently cloned. Under the conditions of the examples, a pair of a TCR α chain and TCR β chain could be obtained from stimulated T cells sorted as single cells at a ratio of 100%. | 2015-07-23 |
20150203887 | HOMOPOLYMER MEDIATED NUCLEIC ACID AMPLIFICATION - According to some aspects of the invention, provided herein are methods of amplifying nucleic acids using homopolymer-dedicated ligation. The methods, in some embodiments, comprise adding a first homopolymer of at least 12 nucleotides to each 3′ end of blunt-ended double-stranded nucleic acid containing a target nucleic acid, thereby producing a partially double-stranded nucleic acid. | 2015-07-23 |
20150203888 | Capping-Prone RNA Polymerase Enzymes and Their Applications - The invention provides a chimeric enzyme comprising at least one catalytic domain of a RNA triphosphatase, at least one catalytic domain of a guanylyltransferase, at least one catalytic domain of a N | 2015-07-23 |
20150203889 | Procedure For The Production Of Tiacumicin B - The present invention relates to a procedure for the production of tiacumicin B comprising fermentation of a micro-organism capable of producing tiacumicin B, in particular of the species | 2015-07-23 |
20150203890 | PRODUCTION OF SIALYLATED N-GLYCANS IN LOWER EUKARYOTES - The present invention relates to eukaryotic host cells which have been modified to produce sialylated glycoproteins by the heterologous expression of a set of glycosyltransferases, including sialyltransferase and/or trans-sialidase, to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. Novel eukaryotic host cells expressing a CMP-sialic acid biosynthetic pathway for the production of sialylated glycoproteins are also provided. The invention provides nucleic acid molecules and combinatorial libraries which can be used to successfully target and express mammalian enzymatic activities (such as those involved in sialylation) to intracellular compartments in a eukaryotic host cell. The process provides an engineered host cell which can be used to express and target any desirable gene(s) involved in glycosylation. | 2015-07-23 |
20150203891 | Method of Making Collagen Powder From Marine Cartilage and Skin - A method of making hydrolyzed marine Type II collagen includes the mixing of marine cartilage, water, an enzyme and a protease enzyme for an extended period of time. Once mixed, the mixture is heated for a period of time at 150° F. Once heated, the enzymes are deactivated, the bone sediment separated, and the fat removed. Next, maltodextrin is added to the mixture and finally the mixture is spray dried to form a collagen powder. | 2015-07-23 |
20150203892 | METHOD FOR DETERMINING BREAST CANCER - The present invention relates to: a breast cancer marker which is selected from the group consisting of carboxypeptidase N subunit 2, extracellular matrix protein 1, serum amyloid P component, nebulin, complement component C8 α chain, apolipoprotein L1, flavin reductase, catalase, carbonic anhydrase 2, apolipoprotein C—I, nuclear pore glycoprotein 210, superoxide dismutase [Cu—Zn], bisphosphoglycerate mutase, carbonic anhydrase 1 and peroxiredoxin-2; a method for determining breast cancer, which comprises detecting the breast cancer marker in a sample and determining breast cancer on the basis of the results of the detection; and a kit for use in the method. | 2015-07-23 |
20150203893 | Concurrently Evaluating Multiple Disease States Via Processing A Bio-Sample With A Single Multi-Channel Micro-Channel Device - A method concurrently evaluates multiple different disease states of a subject with a single multi-channel micro-channel device. The method includes obtaining a bio-sample of the subject. The method further includes concurrently processing a first sub-portion of the bio-sample in a first channel and a second different sub-portion of the bio-sample in a second different channel of the device. The method further includes performing a first comparison of a first result of the processing of the first sub-portion with a first disease profile corresponding to the first disease and a second comparison of a second result of the processing of the second sub-portion with a second disease profile corresponding to the second disease. The method further includes generating a signal indicating a presence or absence of the first disease and a presence or absence of the second disease respectively in response to the first comparison and the second comparison. | 2015-07-23 |
20150203894 | METHOD FOR PREPARING SAMPLE FOR NUCLEIC ACID AMPLIFICATION REACTION AND PREPARATION DEVICE OF SAMPLE FOR NUCLEIC ACID AMPLIFICATION REACTION - There is provided a method for preparing a sample for a nucleic acid amplification reaction, the method including a heating step of applying heat to a nucleic acid-containing sample, and an electrodialysis step of bringing an electrical conductivity of the sample to 2,000 μS/cm or less. | 2015-07-23 |
20150203895 | Spherical, Magnetizable Polyvinyl Alcohol Microparticles, Methods for Their Production, and Their Use - Spherical, magnetizable polyvinyl alcohol microparticles, methods for their production, and use thereof are provided in the invention. The microparticles are especially useful for diagnostic purposes. The method enables the production of microparticles having a particle size distribution in the range of 0.5 to 3 μm, and includes the following steps, dispersing a nanoparticulate, magnetizable material in an aqueous phase which contains polyvinyl alcohol in dissolved form, adding the aqueous phase to an organic phase, immiscible with said aqueous phase and containing at least one emulsifier, producing an emulsion by stirring at a temperature of 25° C. or higher, and adding at least one water-soluble crosslinking agent while stirring is continued. | 2015-07-23 |
20150203896 | Optical Lens System and Method for Microfluidic Devices - An apparatus for imaging one or more selected fluorescence indications from a microfluidic device. The apparatus includes an imaging path coupled to least one chamber in at least one microfluidic device. The imaging path provides for transmission of one or more fluorescent emission signals derived from one or more samples in the at least one chamber of the at least one microfluidic device. The chamber has a chamber size, the chamber size being characterized by an actual spatial dimension normal to the imaging path. The apparatus also includes an optical lens system coupled to the imaging path. The optical lens system is adapted to transmit the one or more fluorescent signals associated with the chamber. | 2015-07-23 |
20150203897 | COMPOSITIONS AND METHOD FOR MEASURING AND CALIBRATING AMPLIFICATION BIAS IN MULTIPLEXED PCR REACTIONS - Compositions and methods are described for standardizing the DNA amplification efficiencies of a highly heterogeneous set of oligonucleotide primers as may typically be used to amplify a heterogeneous set of DNA templates that contains rearranged lymphoid cell DNA encoding T cell receptors (TCR) or immunoglobulins (IG). The presently disclosed embodiments are useful to overcome undesirable bias in the utilization of a subset of amplification primers, which leads to imprecision in multiplexed N high throughput sequencing of amplification products to quantify unique TCR or Ig encoding genomes in a sample. Provided is a composition comprising a diverse plurality of template oligonucleotides in substantially equimolar amounts, for use as a calibration standard for amplification primer sets. Also provided are methods for identifying and correcting biased primer efficiency during amplification. | 2015-07-23 |
20150203898 | Method For Differentiating Between Living And Dead Cells - The present invention relates to a method for quantitatively determining living and dead cells in a biological sample. The method according to the present invention is based on the determination of the amount of DNA in the sample with the aid of a DNA amplification reaction which does not impair the membrane integrity of living cells. | 2015-07-23 |
20150203899 | DIAGNOSIS OF ACTIVE TUBERCULOSIS BY DETERMINING THE MRNA EXPRESSION LEVELS OF MARKER GENES IN BLOOD - The present disclosure relates to a method of distinguishing active TB in the presence of a complicating factor, for example, latent TB and/or co-morbidities, such as those that present similar symptoms to TB, such as HIV. The method employs a 27 gene signature to distinguish active tuberculosis from latent TB infection, a 44 gene signature to distinguish active TB from other diseases such as HIV and/or a 53 gene signature to discriminate active TB from latent TB and other diseases. The disclosure also relates to a gene signature employed in the method, a bespoke gene chip for use in the method and a disease risk score obtainable from the method. | 2015-07-23 |
20150203900 | Methods of Diagnosing Infectious Disease Pathogens and Their Drug Sensitivity - The specification relates generally to methods of detecting, diagnosing, and/or identifying pathogens, e.g., infectious disease pathogens and determining their drug sensitivity and appropriate methods of treatment. This invention also relates generally to methods of monitoring pathogen infection in individual subjects as well as larger populations of subjects. | 2015-07-23 |
20150203901 | COMPOSITIONS AND METHODS FOR DETECTION OF SALMONELLA SPECIES - Described are compositions, methods and kits for detection and/or differential detection of serovars of | 2015-07-23 |
20150203902 | NUCLEIC ACID PROBE, METHOD FOR DESIGNING NUCLEIC ACID PROBE, AND METHOD FOR DETECTING TARGET SEQUENCE - The present invention provides a nucleic acid probe that can achieve high detection sensitivity and high specificity in mutation detection, mismatch detection, etc. by the PCR method, a method for designing such a nucleic acid probe, and a method for detecting a target sequence. The nucleic acid probe includes a nucleic acid molecule, and the nucleic acid molecule includes a plurality of fluorescent dye moieties that exhibit an excitonic effect. At least two of the fluorescent dye moieties that exhibit an excitonic effect are bound to the same base or two adjacent bases in the nucleic acid molecule with each fluorescent dye moiety being bound via a linker (a linking atom or a linking atomic group). The extension-side end of the nucleic acid molecule is chemically modified, thereby preventing an extension reaction of the nucleic acid molecule. | 2015-07-23 |
20150203903 | Arrays and Methods of Use - Methods are provided for producing a molecular array comprising a plurality of molecules immoblised to a solid substrate at a density which allows individual immobilised molecules to be individually resolved, wherein each individual molecule in the array is spatially addressable and the identity of each molecule is known or determined prior to immobilisation. The use of spatially addressable low density molecular arrays in single molecule detection and analysis techniques is also provided. Novel assays and methods are also provided. | 2015-07-23 |
20150203904 | NUCLEIC ACID AMPLIFICATION AND DETECTION KIT - A nucleic acid amplification and detection kit, including: a buffer storage assembly, including a buffer storage reservoir storing a buffer solution therein; a nucleic acid amplification assembly including a nucleic acid amplification reservoir storing one or more reagents therein and configured to receive a sample containing nucleic acid for amplification therein, wherein the buffer storage assembly is configured to couple with the nucleic acid amplification assembly to seal within the nucleic acid amplification reservoir the sample containing nucleic acid and amplification products of the amplification; and a test strip assembly including a lateral flow test strip disposed therein, the test strip assembly and the coupled nucleic acid amplification and buffer storage assemblies being configured to couple with one another and including one or more solution release components to release the amplification products from the nucleic acid amplification reservoir onto the lateral flow test strip for testing, and to release the stored buffer solution from the buffer storage reservoir to flush the released amplification products along the lateral flow test strip. | 2015-07-23 |
20150203905 | METHOD FOR AMPLIFYING NUCLEIC ACID AND METHOD FOR DETECTING AMPLIFIED NUCLEIC ACID - An object of the present invention is to provide methods for amplifying and detecting a nucleic acid that allow efficient hybridization, and devices and kits for use in the methods. The present invention includes amplifying a target nucleic acid into a double-stranded nucleic acid having a single-stranded region at each end, and detecting this nucleic acid. The present invention also provides detection devices and kits that make use of these methods. | 2015-07-23 |
20150203906 | METHODS FOR ADDING ADAPTERS TO NUCLEIC ACIDS AND COMPOSITIONS FOR PRACTICING THE SAME - Provided are methods of adding adapters to nucleic acids. The methods include combining in a reaction mixture a template nucleic acid, a template switch oligonucleotide, a polymerase, and dNTPs. The reaction mixture components are combined under conditions sufficient to produce a product nucleic acid that includes the template nucleic acid and the template switch oligonucleotide each hybridized to adjacent regions of a single product nucleic acid including a region polymerized from the dNTPs by the polymerase. The methods further include attaching sequencing platform adapter constructs to ends of the product nucleic acid or a derivative thereof. Aspects of the invention further include compositions and kits. | 2015-07-23 |
20150203907 | GENOME CAPTURE AND SEQUENCING TO DETERMINE GENOME-WIDE COPY NUMBER VARIATION - Provided herein is a capture library for target enrichment of sequences of interest from a genome DNA sample. The capture library comprises a plurality of capture oligos tiling a plurality of capture regions evenly-spaced along a genome. Each two adjacent capture regions of the plurality capture regions are separated by a spacing of about 6 to about 14 kilobases in length. The plurality of capture regions has a size of about 150 base pairs in length. Further, each capture oligo of the plurality of capture oligos comprises average 70 nucleotides in length. The capture libraries are suitable for enriching about 150 base pairs region approximately every 10 kilobases in a genome DNA. This capture library can be used to measure replication timing and copy number variation in human pediatric acute lymphocytic leukemia samples, and is also broadly applicable to any CNV application. | 2015-07-23 |
20150203908 | SEQUENCING REACTIONS WITH LITHIUM FOR PULSE WIDTH CONTROL - Compositions, kits, methods and systems for single molecule nucleotide sequencing comprising producing polymerase reactions having lithium that control the median pulse width for incorporated nucleotides are disclosed. The levels of lithium are used to control pulse width while allowing other sequencing parameters to remain within a desirable range. | 2015-07-23 |
20150203909 | SUBSTRATES, SYSTEMS AND METHODS FOR ANALYZING MATERIALS - Substrates, systems and methods for analyzing materials that include waveguide arrays disposed upon or within the substrate such that evanescent fields emanating from the waveguides illuminate materials disposed upon or proximal to the surface of the substrate, permitting analysis of such materials. The substrates, systems and methods are used in a variety of analytical operations, including, inter alia, nucleic acid analysis, including hybridization and sequencing analyses, cellular analyses and other molecular analyses. | 2015-07-23 |
20150203910 | Method for Sequencing a Polynucelotide Template - The invention provides methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template. | 2015-07-23 |
20150203911 | METHOD FOR SEQUENCING A POLYNUCLEOTIDE TEMPLATE - The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which permit the sequential determination of nucleotide sequences in two distinct and separate regions on complementary strands of the double-stranded polynucleotide template. The two regions for sequence determination may or may not be complementary to each other. | 2015-07-23 |
20150203912 | PROTEIN DETECTION USING FET - Accordingly, in some embodiments methods for detecting an analyte or analytes in one or more sample(s) are provided. The methods encompass providing a solid support with an addressable marker and an associated ligand, contacting the solid substrate to a sample, thereby forming a contacted solid support, associating the contacted solid support with a FET array and detecting the electrical properties of the FET array and thereby detecting an analyte or analytes in one or more samples. In other embodiments, the sample encompasses a second addressable marker. | 2015-07-23 |
20150203913 | MULTIPLEX NUCLEIC ACID REACTIONS - A method for detecting nucleic acids by (a) providing a sample having target nucleic acids, each nucleic acid having contiguous first, second, and third domains; (b) contacting the sample with probe sets to form hybridization complexes, wherein each probe set includes (i) a first probe having a sequence that is complementary to the first domain; and (ii) a second probe having a sequence substantially complementary to the third domain; (c) extending the first probes along the second domains of the complexes while the complexes are immobilized on a solid support; (d) ligating the extended first probes to the second probes to form templates; (e) amplifying the templates with primers that are complementary to the first and second priming sequences to produce amplicons; and (f) detecting the amplicons on the surface of a nucleic acid array. | 2015-07-23 |
20150203914 | METHOD OF DETERMINING THE FRACTION OF FETAL DNA IN MATERNAL BLOOD USING HLA MARKERS - The invention comprises a method of determining the fraction of fetal DNA in maternal blood or plasma using HLA locus wherein the maternal and fetal HLA alleles are detected and quantified by clonal or digital methods. | 2015-07-23 |
20150203915 | Screening Methods for Transfusion Related Acute Lung Injury (TRALI) - The invention relates to the discovery that HNA-3a and HNA-3b are antigens within a polypeptide sequence that is highly similar to the CTL2 amino acid sequence. This invention provides methods and kits for screening for HNA-3a and HNA-3b specific antibodies, HNA-3a and HNA-3b polypeptides and HNA-3a and HNA-3b nucleic acids in a sample of a biological tissue intended for transplantation | 2015-07-23 |
20150203916 | PLASMA ANALYTES PREDICT DIAGNOSIS AND PROGNOSIS OF THORACIC AORTIC ANEURYSM - Disclosed are methods and materials for assessing thoracic aortic aneurysm using a combination of protein and microRNA biomarkers. The presence or levels of the biomarkers can be measured in a body fluid, such as plasma and serum, or in cardiac tissue, to predict the presence and severity of TAA in a subject. This can be used to diagnose and monitor TAA, providing early detection of a lethal and silent disease, as well as reduce the frequency of radiological procedures, which are costly and potentially dangerous. | 2015-07-23 |
20150203917 | PROGNOSIS BIOMARKERS IN CARTILAGE DISORDERS - This application is directed to the use of biomarkers for prognosing disease severity in a subject having a cartilage disorder, such as osteoarthritis, cartilage injury, fractures affecting joint cartilage or surgical procedures with impact on joint cartilage (e.g., microfracture). It also describes a method of predicting sensitivity to a drug prior to drug administration in a subject having a cartilage disorder, as well as clinical management based on the likelihood of said patients of being non-sensitive, sensitive or highly sensitive to a drug treatment. | 2015-07-23 |
20150203918 | MUTATED ACVR1 FOR DIAGNOSIS AND TREATMENT OF FIBRODYPLASIA OSSIFICANS PROGRESSIVA (FOP) - This invention is directed to mutated Activin A type I receptor proteins (ACVR1) and isolated nucleic acids encoding same. The invention also relates to the use of mutated ACVR1 in the diagnosis and treatment of Fibrodysplasia Ossificans Progressiva (FOP). | 2015-07-23 |
20150203919 | METHODS FOR PREDICTING THE SURVIVAL TIME AND TREATMENT RESPONSIVENESS OF A PATIENT SUFFERING FROM A SOLID CANCER WITH A SIGNATURE OF AT LEAST 7 GENES - The present invention relates to a method for predicting the survival time of a patient suffering from a solid cancer comprising i) determining in a tumor sample obtained from the patient the gene expression level of at least 7 genes selected from the group consisting of CCR2, CD3D, CD3E, CD3G, CD8A, CXCL10, CXCL11, GZMA, GZMB, GZMK, GZMM, IL15, IRF1, PRF1, STAT1, CD69, ICOS, CXCR3, STAT4, CCL2, and TBX21, ii) comparing every expression level determined at step i) with their predetermined reference value and iii) providing a good prognosis when all expression levels determined at step i) are higher than their predetermined reference values, or providing a bad prognosis when all expression levels determined at step i) are lower than their predetermined reference values or providing an intermediate prognosis when at least one expression level determined value is higher than its predetermined value. The method is also particularly suitable for predicting the responsiveness of the patient to a treatment. | 2015-07-23 |
20150203920 | COMPOSITIONS AND METHODS FOR USING TRANSFER RNA FRAGMENTS AS BIOMARKERS FOR CANCER - Analysis of over 50 short RNA libraries revealed that tRFs are present in all human cell lines and exist in mice, flies, worms, and yeasts. Specific tRNA genes yield tRFs generated by cleavage at sites conserved across different cells within a species, and all three potential tRFs from a given tRNA gene were not always present or equally abundant. tRF-1 and -3 were highly abundant in the cytoplasm, while tRF-5 were mostly in the nucleus. tRF-5 and -3 were found in adult mouse tissues, tRF-1 were relatively rare in adult tissues but in greater amounts in mouse embryos and embryonic stem cells. Several tRF-1 sequences were conserved between mice and humans and expression was tissue-specific. tRFs are shown to be markers for cancer. For example greater amounts of tRF-1 were found in B cell malignancies compared to normal B cell, and tRF-5 and -3 were at higher levels in lung cancer compared to normal lung. | 2015-07-23 |
20150203921 | PREDICTING BREAST CANCER RECURRENCE - Provided are methods of determining risk of cancer recurrence in a subject afflicted with breast cancer. Also provided are methods of determining responsiveness to treatment of a subject afflicted with breast cancer. Additionally provided are methods of treating a subject afflicted with breast cancer. | 2015-07-23 |
20150203922 | Portable Systems and Methods for Amplifying Nucleotides and Detecting Nucleotide Sequences - Portable systems and methods for amplifying nucleotides and for detecting nucleotide sequences in a sample are provided. The portable instruments and methods use RPA techniques for DNA amplification and detect sample fluorescence in response to amplification and/or to the presence of specific DNA sequences. | 2015-07-23 |
20150203923 | MOLECULAR MARKERS ASSOCIATED WITH CHLORIDE TOLERANT SOYBEANS - The present invention provides methods and compositions for the identification and selection of loci modulating phenotypic expression of a chloride tolerant trait in plant breeding. In addition, methods are provided for screening germplasm entries for the performance and expression of this trait. | 2015-07-23 |
20150203924 | DIAGNOSTIC TOOLS FOR HERBICIDE RESISTANCE IN PLANTS - Embodiments of the present disclosure relate generally to kits for identifying herbicide resistant plants and methods for determining whether a plant is herbicide resistant. The methods are based on the discovery that some genes are over-expressed or under-expressed in herbicide resistant plants when compared to herbicide-sensitive plants prior to application of the herbicide. The methods include determining the expression level of the one or more genes of interest in a biological sample, such as via qRT PCR, and determining whether the biological sample is from an herbicide-resistant plant based on the expression level. In an embodiment, the kit and methods are used to identify glyphosate-resistant | 2015-07-23 |
20150203925 | LIQUID CRYSTAL BASED ANALYTE DETECTION - The present invention relates to the field of detection of viruses, and in particular to detection of viruses using a liquid crystal assay format. In the present invention, virus binding in a detection region is identified by changes in liquid crystal orientation caused by virus binding independent orientation caused by any topography associated with the detection region. | 2015-07-23 |
20150203926 | PRIMER SET FOR DETECTING BOVINE LEUKEMIA VIRUS AND USE THEREOF - A forward primer of a primer set in accordance with the present invention for detecting BLV is a mixture of (1) a first primer consisting of a polynucleotide including 15 or more successive bases including the 16th C in the base sequence of SEQ ID NO: 1 and (2) a second primer consisting of a plurality of kinds of polynucleotides including at least the first to 15th bases in the base sequence of SEQ ID NO: 2. Two or more of M, N, Y, K, and D which are included in the second primer are each a degenerate base which specifies two or more kinds of bases, and the second primer includes at least 10 kinds of polynucleotides including at least the first to 15th bases in the base sequences of SEQ ID NOs: 3 to 12. | 2015-07-23 |
20150203927 | METHOD OF PRODUCING SUGAR SOLUTION - A method of producing a sugar liquid includes filtering a cellulose-derived sugar liquid through one or more separation membranes selected from the group consisting of an ultrafiltration membrane, a nanofiltration membrane and a reverse osmosis membrane and washing the separation membrane(s) after filtration with washing water containing an alkaline substance and an aromatic compound at 10° C. or more and less than 50° C. | 2015-07-23 |
20150203928 | PROCESS FOR DRY RECYCLING AND PROCESSING OF STEEL SLAG - The present invention relates to a process for recycling and processing steel slag, comprising the removal of the metal fractions of the slag in an innovative separation system and through the metal-free material, to produce granules of ore and steel shot, sealing block, apparent blocks, building blocks, interlocking floors in all models, caissons, guides, masonry mortar, adhesive mortar, floor on floor mortar, pumpable mortars, grouts, colored grouts, flexible grouts, epoxy grouts, epoxy masses, replacing natural minor aggregates, as the sand and crushing stone by steel slag in their proper particle size and especially the replacement of 100% of the conventional cement produced by a steel slag cement, applying additives from 0.1% to 30% of additives, depending on the application of each product. The invention belongs to the recycling area, specifically the recycling of steel slag. | 2015-07-23 |
20150203929 | METHOD FOR PRODUCING PIG IRON AND BLAST FURNACE FACILITY USING SAME - This blast furnace facility is provided with: a blast furnace main body ( | 2015-07-23 |
20150203930 | METHOD FOR PREPARING BLAST FURNACE BLOW-IN COAL - On the basis of data obtained by means of analyzing coal, a first and second coal type satisfying conditions are selected, the ash melting point of the mixed coal resulting from mixing the first and second coal types is derived on the basis of a four-dimensional state diagram for SiO | 2015-07-23 |
20150203931 | METHOD FOR PRODUCING METALLIC IRON - The first purpose of the present invention is to provide a method for producing metallic iron, whereby, in the production of metallic iron by heating an agglomerate, which comprises an iron oxide-containing material and a carbonaceous reductant, in a movable hearth type heating furnace, metallic iron can be efficiently collected from a reduced product containing metallic iron and a slag, said reduced product being obtained by heating the agglomerate. The method for producing metallic iron according to the first embodiment of the present invention comprises: a step for forming an agglomerate of a mixture which comprises an iron oxide-containing material and a carbonaceous reductant; a step for introducing the obtained agglomerate into a movable hearth type heating furnace and reducing the same by heating; a step for crushing a reduced product containing metallic iron and a slag, said reduced product being discharged from the movable hearth type heating furnace, using an impact crusher; and a step for selecting and collecting the metallic iron using a separator. | 2015-07-23 |
20150203932 | PROCESS FOR MANUFACTURING STEEL SHEET HAVING HIGH TENSILE STRENGTH AND DUCTILITY CHARACTERISTICS, AND SHEET THUS PRODUCED - The invention relates to a hot-rolled steel sheet having a tensile strength greater than 800 MPa and an elongation at break greater than 10%, the composition of which comprises, the contents being expressed by weight: 0.050%≦C≦0.090%, 1%≦Mn≦2%, 0.015%≦Al≦0.050%, 0.1%≦Si≦0.3%, 0.10%≦Mo≦0.40%, S≦0.010%, P≦0.025%, 0.003%≦N≦0.009%, 0.12%≦V≦0.22%, Ti≦0.005%, Nb≦0.020% and, optionally, Cr≦0.45%, the balance of the composition consisting of iron and inevitable impurities resulting from the smelting, the microstructure of the sheet or the part comprising, as a surface fraction, at least 80% upper bainite, the possible complement consisting of lower bainite, martensite and residual austenite, the sum of the martensite and residual austenite contents being less than 5%. | 2015-07-23 |
20150203933 | HIGH-STRENGTH ELECTRIC-RESISTANCE-WELDED STEEL PIPE OF EXCELLENT LONG-TERM SOFTENING RESISTANCE IN INTERMEDIATE TEMPERATURE RANGES, AND METHOD OF PRODUCING SAME - A high strength electric resistance welded steel pipe has a yield strength of 450 MPa or more and excellent resistance to softening for a long period in an intermediate temperature range and a method of manufacturing the steel pipe are provided. The steel pipe has a chemical composition containing, by mass%, C: 0.026% or more and 0.084% or less, Si: 0.10% or more and 0.30% or less, Mn: 0.70% or more and 1.90% or less, Al: 0.01% or more and 0.10% or less, Nb: 0.001% or more and 0.070% or less, V: 0.001% or more and 0.065% or less, Ti: 0.001% or more and 0.033% or less, Ca: 0.0001% or more and 0.0035% or less, in which the condition that Pcm is 0.20 or less is satisfied. | 2015-07-23 |
20150203934 | STRIP MATERIAL WITH EXCELLENT CORROSION RESISTANCE AFTER BRAZING - A corrosion resistant strip is disclosed. The strip comprises a core, and an interlayer adapted to be located between the core and an optional Al—Si based clad. The interlayer has a composition essentially consisting of (in percentages by weight): Si≦0.9%, Fe≦0.7%, Cu≦0.5%, Mn0.5-1.8%, Mg≦0.7%, Zn≦4.0%, Ni≦1.5%, elements selected from group IVb, Vb, and/or VIb of the periodic table ≦0.3% each and ≦0.5% in total ≦0.05 wt % each and ≦0.15% in total, of unavoidable impurity elements, balance Al. The core is more noble than the interlayer after brazing. The interlayer exhibits a volume fraction of a texture component of at least 30%. | 2015-07-23 |
20150203935 | METAL LEACH AND RECOVERY PROCESS - The present invention relates to a metal leach and recovery process. The process involves subjecting a metal bearing material to a reactive process by combining said metal bearing material with a leaching agent to liberate at least one metal value and forming a first aqueous leach pulp. This first aqueous leach pulp is subjected to a solid liquid separation step thereby providing a first clarified aqueous leach solution and a second aqueous leach pulp. The first clarified aqueous leach solution is then subjected to solvent extraction thereby obtaining the first aqueous raffmate. The second aqueous leach pulp is subjected to at least two further solid liquid separation steps of which some or all are in a counter current decantation (CCD) arrangement. Each of the solid liquid separation steps of the CCD arrangement results in an aqueous liquor and aqueous suspension of solids wherein each aqueous suspension of solids resulting from each solid liquid separation step of the CCD arrangement is passed to the subsequent solid liquid separation step and the suspension of solids resulting from the final solid liquid separation step is removed from the process. Further, each aqueous liquor resulting from each solid liquid separation step of the CCD arrangement is passed to the previous solid liquid separation step. The further solid liquid separation steps result in at least one further clarified aqueous leach solution. The at least one further clarified aqueous leach solution is/are subjected to solvent extraction thereby obtaining at least one further aqueous raffinate. At least a portion of the one or more of the at least one further aqueous raffmates is fed into the final solid liquid separation is of the CCD arrangement. The process provides a flocculation system comprising either: (i) addition of an organic polymeric flocculant to or prior to at least one solid liquid separation step, which polymeric flocculant is formed from 2-acrylamido-2-methylpropane sulphonic acid (ATBS) or salts thereof as a homopolymer or copolymer with at least one water-soluble ethylenically unsaturated monomer; or (ii) addition of an organic polymeric flocculant and at least one support agent to or prior to at least one solid liquid separation step, which at least one support agent is selected from at least one of the group consisting of oxidising agents, reducing agents, irradiation and free radical producing agents. The process provides significantly improved metal extraction and recovery. | 2015-07-23 |
20150203936 | METHOD FOR PRODUCING ALUMINA - The invention relates to metallurgy, particularly to acid methods or producing alumina, and can be used in processing low-grade aluminum-containing raw materials. The method for producing alumina comprises treating aluminum-containing raw materials with hydrochloric acid, crystallizing aluminum chloride hexahydrate by means of evaporating the supernatant chloride solution, and thermally decomposing the to form alumina. In order to increase the quality of the alumina and decrease energy consumption, crystallization is carried out with the addition of calcium chloride, wherein the ratio of the total mass of calcium chloride to the calculated mass of alumina in the supernatant solution equals | 2015-07-23 |
20150203937 | METHOD FOR REDUCING ALUMINA OR MAGNESIA BY UTILIZING SUPERSONIC GAS FLOW - An alumina- or magnesia-reducing process in which a greenhouse gas or substance harmful to the human body is not emitted, which can achieve improved energy efficiency in comparison with the Hall-Heroult or Pidgeon methods. The process includes: introducing an alumina or magnesia powder with a carrier gas to the upstream side of a throat provided on a reducing unit; pressure-transferring the powder and carrier gas to the throat by an operative gas introduced to the upstream side of the throat; irradiating the throat with a laser beam to convert the alumina or magnesia into a plasma state and dissociate the alumina or magnesia thermally; jetting the thermally dissociated product through a nozzle provided on the downstream side of the throat at a supersonic speed to form a frozen flow; and isolating aluminum or magnesium. Hydrogen may be added to the operative gas to accelerate the reduction of alumina or magnesia. | 2015-07-23 |
20150203938 | METHOD FOR LEACHING VALUABLE METALS CONTAINED IN WASTE DENITRIFICATION CATALYST BY USING ROASTING AND WATER LEACHING - Disclosed is a method for effectively leaching valuable metals such as vanadium and tungsten contained in a waste denitrification catalyst by using roasting and water leaching. According to the present invention, the method for leaching valuable metals contained in a waste denitrification catalyst comprises the steps of: (a) mixing a waste denitrification catalyst containing vanadium (V) and tungsten (W) in the form of an oxide with an alkali metal compound to form a mixture; (b) roasting the mixture to generate a roasting product comprising sodium vanadate (NaVO | 2015-07-23 |
20150203939 | PROCESSES FOR THE RECOVERY OF URANIUM FROM WET-PROCESS PHOSPHORIC ACID USING DUAL OR SINGLE CYCLE ION EXCHANGE APPROACHES - In alternative embodiments, the invention provides processes and methods for the recovery, removal or extracting of, and subsequent purification of uranium from a wet-process phosphoric acid using a continuous ion exchange processing approach, where the uranium is recovered from a phosphoric acid, or a phos-acid feedstock using either a dual or a single stage extraction methodology. In both cases an intermediate ammonium uranyl-tricarbonate solution is formed. In alternative embodiments, in the dual cycle approach, this solution is contacted in a second continuous ion exchange system with a strong anion exchange resin then subsequently recovered as an acidic uranyl solution that is further treated to produce an intermediate uranyl peroxide compound which is ultimately calcined to produce the final uranium oxide product. In alternative embodiments, in the single cycle case, the intermediate ammonium uranyl-tricarbonate solution is evaporated to decompose the ammonium carbonate and produce an intermediate uranium carbonate/oxide solid material. These solids are digested in an acid medium, and then processed in the same manner as the secondary regeneration solution from the dual cycle process to produce an intermediate uranyl peroxide that is calcined to produce a final uranium oxide product. | 2015-07-23 |
20150203940 | BRASS ALLOY AND METHOD FOR MANUFACTURING THE SAME - A brass alloy, with a total weight percentage thereof counted as 100 wt %, includes the following elements: 60 wt % to 65 wt % of copper, 0.1 wt % to 0.35 wt % of bismuth, 0.15 wt % to 0.5 wt % of antimony, a balance of zinc, and an inevitable impurity. | 2015-07-23 |
20150203941 | ALUMINUM ALLOY FOIL AND METHOD FOR MANUFACTURING SAME - An aluminum alloy foil having superior formability is provided. An aluminum alloy foil, including 0.8 to 2.0 mass % of Fe, 0.05 to 0.2 mass % of Si, and 0.0025 to 0.5 mass % of Cu, with the rest consisting of Al and unavoidable impurities, wherein the aluminum alloy foil has an average crystal grain size of 20 μm or less, and a number of intermetallic compounds existing in the aluminum alloy foil, the intermetallic compounds having a circle equivalent diameter of 1.0 to 5.0 μm, is 1.0×10 | 2015-07-23 |
20150203942 | 6XXX ALUMINUM ALLOYS - New 6xxx aluminum alloys having an improved combination of properties are disclosed. The new 6xxx aluminum alloy generally include from 0.30 to 0.53 wt. % Si, from 0.50 to 0.65 wt. % Mg wherein the ratio of wt. % Mg to wt. % Si is at least 1.0:1 (Mg:Si), from 0.05 to 0.24 wt. % Cu, from 0.05 to 0.14 wt. % Mn, from 0.05 to 0.25 wt. % Fe, up to 0.15 wt. % Ti, up to 0.15 wt. % Zn, up to 0.15 wt. % Zr, not greater than 0.04 wt. % V, and not greater than 0.04 wt. % Cr, the balance being aluminum and other elements. | 2015-07-23 |
20150203943 | STEEL FOR INDUCTION HARDENING WITH EXCELLENT FATIGUE PROPERTIES - A steel for induction hardening includes as a chemical composition, by mass %, C: 0.45% to 0.85%, Si: 0.01% to 0.80%, Mn: 0.1% to 1.5%, Al: 0.01% to 0.05%, REM: 0.0001% to 0.050%, O: 0.0001% to 0.0030%. Ca: 0.0050% or less as necessary, Ti: less than 0.005%, N: 0.015% or less, P: 0.03% or less, S: 0.01% or less, and the balance consists of Fe and impurities. The steel for induction hardening also includes a composition inclusion which is an inclusion containing REM, O, S, and Al, or an inclusion containing REM, Ca, O, S, and Al, to which TiN is adhered. | 2015-07-23 |
20150203944 | AUSTENITIC STEEL ALLOY HAVING EXCELLENT CREEP STRENGTH AND RESISTANCE TO OXIDATION AND CORROSION AT ELEVATED USE TEMERATURES - An austenitic steel alloy having excellent creep strength and resistance to oxidation and corrosion at elevated use temperatures up to approximately 750° C. has the following chemical composition (in weight %): 0.02≦C≦0.15%; 0.1≦Si≦2.0%; 25≦Cr≦33%; 22≦Ni≦38%; 1≦Mo≦6%; 0.4≦Nb≦1.5%; B≦0.0120%; 0.01≦N≦0.2%; Mn≦2%; Co≦5%; W≦2%; Al≦0.05%; Cu≦5%; Ti≦0.5%; Ta≦0.5%; V≦0.5%; P≦0.05%; S≦0.05%, Remainder iron with melting related impurities and optional addition of rare earths and reactive elements such as Ce, Hf, La, Re, Sc and/or Y of together 1%. | 2015-07-23 |
20150203945 | THICK-WALLED, HIGH TENSILE STRENGTH STEEL WITH EXCELLENT CTOD CHARACTERISTICS OF THE WELD HEAT-AFFECTED ZONE, AND MANUFACTURING METHOD THEREOF - A thick-walled high-strength steel plate with excellent low-temperature toughness (Charpy impact and CTOD properties of a weld bond) in a multilayer weld zone, and a method for manufacturing the steel plate. | 2015-07-23 |
20150203946 | Hot-Rolled Flat Steel Product and Method For the Production Thereof - A hot-rolled flat steel product having a product of Rm and A80 of ≧18,000 MPa*%, a composition including (in wt.) C:0.10-0.60%, Si:0.4-2.0%, Al:≦2.0%, Mn:0.4-2.5%, Ni:≦1%, Cu:≦2.0%, Mo:≦0.4%, Cr≦2%, Ii:≦0.2%, Nb:≦0.2%, V:≦0.5%, remainder Fe and unavoidable impurities, and a microstructure of bainite and residual austenite, wherein the microstructure includes ≧60 vol.% bainite, and wherein at least some of the residual austenite is in block form and ≧98% of the residual austenite blocks have a size of ≦5 μm. Also, a method where a slab, thin slab or a cast strip having the aforementioned composition is hot-rolled at a hot-rolling end temperature of ≧880° C., cooled with a cooling rate of ≧5° C./s to a coiling temperature between the martensite start temperature and 600° C., coiled, and cooled in the coil while being held between the bainite start temperature and the martensite start temperature until ≧60 vol.% of the hot strip microstructure is bainite. | 2015-07-23 |
20150203947 | HIGH-STRENGTH GALVANIZED STEEL SHEET WITH EXCELLENT FORMABILITY AND SHAPE FIXABILITY AND METHOD FOR MANUFACTURING THE SAME - A high-strength galvanized steel sheet with excellent formability and shape fixability and a method for manufacturing the high-strength galvanized steel sheet. | 2015-07-23 |
20150203948 | COLD ROLLED STEEL SHEET, ELECTROGALVANIZED COLD-ROLLED STEEL SHEET, HOT-DIP GALVANIZED COLD-ROLLED STEEL SHEET, ALLOYED HOT-DIP GALVANIZED COLD ROLLED STEEL SHEET, AND MANUFACTURING METHODS OF THE SAME - A cold-rolled steel sheet containing: in mass %, C: 0.0005 to 0.0045%; Mn: 0.80 to 2.50%; Ti: 0.002 to 0.150%; B: 0.0005 to 0.01%, in which (1) Expression is satisfied, and a balance being composed of iron and impurities, in which at the position of ¼ thickness of a sheet thickness, a random intensity ratio (A) of the {332}<110> orientation is 3 or less, a random intensity ratio (B) of the {557}<9 16 5> orientation and a random intensity ratio (C) of the {111}<112> orientation are both 7 or more, and {(B)/(A) 5} and {(B)>(C)} are satisfied. | 2015-07-23 |
20150203949 | DUAL PHASE STEEL SHEET AND MANUFACTURING METHOD THEREOF - A dual phase steel sheet including: in mass %, C: 0.01 to 0.1%; Mn: 0.2 to 3%; Al: 0.04 to 1.5%; Ti: 0.015 to 0.2%; P: 0.01% or less; S: 0.005% or less; N: 0.01% or less, in which [Ti]−48/14×[N]−48/32×[S]≧0% is satisfied and when Ex.C (%)=[C]−12/48×{[Ti]+48/93×[Nb]−48/14×[N]−48/32×[S]} is set, 0.001≦Ex.C (%)/fsd (%)≦0.01 is satisfied, and a balance being composed of Fe and impurities, in which at the position of ¼ thickness of a sheet thickness, a microstructure is a dual phase with its main phase composed of polygonal ferrite precipitation-strengthened by carbide of Ti and its second phase composed of 1 to 10% in area fraction (fsd (%)) of low-temperature transformation products dispersed plurally, and an average crystal diameter of the low-temperature transformation product is 3 to 15 μm and an average value of a distance of closest approach between the low-temperature transformation products is 10 to 20 μm. | 2015-07-23 |