30th week of 2012 patent applcation highlights part 64 |
Patent application number | Title | Published |
20120192296 | PREPARATION OF ISOLATED AGONIST ANTI-EDAR MONOCLONAL ANTIBODIES - The present invention concerns the preparation of substantially purified agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof. The invention further relates to isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof as well as their use in the treatment of X-linked hypohidrotic ectodermal dysplasia and tooth agenesis. The invention also relates to a pharmaceutical composition comprising said isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof and to a method of treating X-linked hypohidrotic ectodermal dysplasia and tooth agenesis. Finally, the present invention concerns a pharmaceutical kit comprising said isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof. | 2012-07-26 |
20120192297 | SCREENING METHOD UTILIZING THALIDOMIDE-TARGETING FACTOR - With an aim to provide means for developing a compound devoid of teratogenicity but retaining beneficial actions, a screening method for a non-teratogenic substance comprising bringing a test substance into contact with cereblon or a fragment of cereblon, evaluating the bindability of the test substance with cereblon or the fragment of cereblon, and selecting a test substance that does not bind to cereblon or the fragment of cereblon or a test substance exhibiting lower bindability with cereblon or the fragment of cereblon than does thalidomide is provided. | 2012-07-26 |
20120192298 | METHOD FOR GENOME EDITING - The present invention encompasses a method for creating an animal or cell with at least one chromosomal edit. In particular, the invention relates to the use of targeted zinc finger nucleases to edit chromosomal sequences. The invention further encompasses an animal or a cell created by a method of the invention. | 2012-07-26 |
20120192299 | INBRED C57BL/6 ES CELLS WITH HIGH DEVELOPMENTAL CAPACITY - Described herein are inbred B6 ES cell lines that exhibit high developmental capacities and have a number of advantages over ES cell lines already available. First, they can be used for gene targeting and have a high percentage of germline transmission when injected into diploid host blastocysts (˜50-80%). Second, these ES cell lines can successfully be used to generate live pups by tetraploid blastocyst complementation, producing a high percentage (15-20%) of mice that are entirely inbred B6 ES cell derived. Third, these ES cells lines can be used to rapidly generate mice that are homozygous for a gene of interest. These advantages indicate that the inbred B6 ES cells provided here facilitate the rapid generation of inbred B6 mouse models in a cost-effective and efficient manner. | 2012-07-26 |
20120192300 | Common Light Chain Mouse - A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline. Methods for making light chain variable regions in mice, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, are provided. | 2012-07-26 |
20120192301 | METHODS AND COMPOSITIONS FOR GENE CORRECTION - Disclosed herein are methods and compositions for correction and/or mutation of genes associated with Parkinson's Disease as well as clones and animals derived therefrom. | 2012-07-26 |
20120192302 | Wheat Variety W000850B1 - A wheat variety designated W000850B1, the plants and seeds of wheat variety W000850B1, methods for producing a wheat plant produced by crossing the variety W000850B1 with another wheat plant, and hybrid wheat seeds and plants produced by crossing the variety W000850B1 with another wheat line or plant, and the creation of variants by mutagenesis or transformation of variety W000850B1. This invention also relates to methods for producing other wheat varieties or breeding lines derived from wheat variety W000850B1 and to wheat varieties or breeding lines produced by those methods. | 2012-07-26 |
20120192303 | Wild Rocket Cultivar 40-0801188-B - A wild rocket cultivar, designated 40-0801188-B, is disclosed. The invention relates to the seeds of wild rocket cultivar 40-0801188-B, to the plants of wild rocket cultivar 40-0801188-B and to methods for producing a wild rocket plant by crossing the cultivar 40-0801188-B with itself or another wild rocket cultivar. The invention further relates to methods for producing a wild rocket plant containing in its genetic material one or more transgenes and to the transgenic wild rocket plants and plant parts produced by those methods. This invention also relates to wild rocket cultivars or breeding cultivars and plant parts derived from wild rocket cultivar 40-0801188-B, to methods for producing other wild rocket cultivars, lines or plant parts derived from wild rocket cultivar 40-0801188-B and to the wild rocket plants, varieties, and their parts derived from the use of those methods. The invention further relates to hybrid wild rocket seeds, plants, and plant parts produced by crossing cultivar 40-0801188-B with another wild rocket cultivar. | 2012-07-26 |
20120192304 | COTTON VARIETY 09R348B2R2 - The invention relates to the novel cotton variety designated 09R348B2R2. Provided by the invention are the seeds, plants, plant parts and derivatives of the cotton variety 09R348B2R2. Also provided by the invention are tissue cultures of the cotton variety 09R348B2R2 and the plants regenerated therefrom. Still further provided by the invention are methods for producing cotton plants by crossing the cotton variety 09R348B2R2 with itself or another cotton variety and plants produced by such methods. | 2012-07-26 |
20120192305 | TOMATO LINE CHI 18-2101 - The invention provides seed and plants of tomato hybrid HNS 12846080 and parent lines thereof. The invention thus relates to the plants, seeds and tissue cultures of such plants, and to methods for producing a tomato plant produced by crossing such plants with themselves or with another tomato plant, including a plant of another genotype. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of such plants, including the fruit and gametes of such plants. | 2012-07-26 |
20120192306 | Method To Develop High Oleic Acid Soybeans Using Conventional Soybean Breeding Techniques - The present invention is directed to a soybean plant with mutations in FAD2-1A and FAD2-1B. Moreover, the present invention is directed to seeds from said plants with altered ratios of monosaturated and polyunsaturated fats. In particular, the present invention is directed to plants where the plants exhibit elevated levels of oleic acid. | 2012-07-26 |
20120192307 | Argyranthemum Intergeneric Hybrid Plants and Methods of Production - New plants were created from a new and efficient method of intergeneric hybridization between the genus | 2012-07-26 |
20120192308 | Method for Providing Fertile Plants via Induction of BBM During Transformation - A method for providing a transgenic plant, including transforming a plant cell or plant material with a nucleotide sequence coding for a BBM protein, wherein activity of the BBM protein is induced during transformation and/or regeneration of the transformed plant cell or plant material, and wherein the plant cell or plant material originates from a recalcitrant plant is provided. In addition, a transgenic plant or material thereof having a BBM protein, wherein the transgenic plant is a recalcitrant plant is also provided. | 2012-07-26 |
20120192309 | REGULATION OF ZINC DEFICIENCY AND TOLERANCE IN PLANTS - The invention relates to a method to change the capacity of a plant for adaptation to changes in the zinc concentration in the environment, especially the soil, comprising providing said plant with a nucleotide according to SEQ ID NO: | 2012-07-26 |
20120192310 | Novel Bacillus thuringiensis Gene With Lepidopteran Activity - The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of | 2012-07-26 |
20120192311 | RIPENING PROMOTER - The presence of expansins was investigated in various developmental and ripening stages of cherry fruits by SDS PAGE and immunoblotting. An expansin gene and three fragments (242, 607, and 929 bp) of its promoter region were cloned. The genomic clone of the expansin gene contained three introns, two exons spanning a 1.6 kb and a 1.0 kb upstream region. Semi quantitative PCR analysis showed that this gene was ripening specific Chimeric promoter—GUS constructs were made and truncated forms of the expansin promoter were introduced into tomatoes by agroinjection and fruits were analyzed for GUS expression by histochemical GUS staining and enzyme activity assays. The 0.60 kb expansin promoter efficiently induced GUS expression in transgenic tomatoes, whereas constructs with the 0.25 kb promoter did not display significant GUS staining. The highest GUS activity was detected in tomatoes containing the 1.0 kb promoter construct. Both large base pair promoter constructs drove the expression of the GUS gene at an equal or higher rate than the tomato E8 promoter. | 2012-07-26 |
20120192312 | Production of Plants with Reduced Lignin Content - The invention relates to the production of plants having a reduced lignin content and in which the cellulose hydrolysis of the walls is increased, via the total or partial inhibition of the expression and/or the activity of two laccases in said plant. | 2012-07-26 |
20120192313 | Method for Modifying Plant Architecture and Enhancing Plant Biomass And/Or Sucrose Yield - The present invention relates to methodology and constructs for modifying plant architecture and enhancing plant biomass and/or sucrose yield. | 2012-07-26 |
20120192314 | METHODS FOR INCREASING PLANT CELL PROLIFERATION BY FUNCTIONALLY INHIBITING A PLANT CYCLIN INHIBITOR GENE - The present invention provides methods for modulating the growth and/or yield of plants. In particular the methods comprises the use of agents which functionally inhibit the expression of plant D-like cyclin inhibitors including isolated polynucleotide sequences which interact with DNA or RNA encoding proteins capable of binding plant D-like cyclins. Further, the present invention provides recombinant polynucleotide sequences, vectors and host cells which encode proteins capable of binding to and inactivating the activity of plant D-like cyclin/cyclin dependent kinase complexes preventing plant cells from exiting the cell cycle. Methods for determining and agents which are inhibitors of the BRO cyclin dependent kinase inhibitor proteins which are capable of modulating plant cell cycle progression are also provided. Methods for the production of transgenic plant cells and plants with increased growth rates and yields when compared to wild-type plants are also provided. | 2012-07-26 |
20120192315 | RESISTANCE GENES AND PROTEINS ACTIVE AGAINST FUSARIUM ROOT ROTS, CYST NEMATODES AND SOYBEAN SUDDEN DEATH SYNDROME AND METHODS EMPLOYING SAME - Fusarium root rot, cyst nematode and soybean sudden death syndrome resistance genes; Fusarium root rot, cyst nematode and soybean sudden death syndrome resistance proteins; Fusarium root rot, cyst nematode and soybean sudden death syndrome resistant plant lines, and methods of breeding and engineering same. | 2012-07-26 |
20120192316 | POLYPEPTIDES HAVING LIPASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME - The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 2012-07-26 |
20120192317 | SELECTING AND STABILIZING dsRNA CONSTRUCTS - The invention provides methods for selecting nucleotide sequences that yield dsRNA-mediated gene suppression in a target organism and enable their uptake by the target organism. The invention further provides expression constructs that confer stabilized expression of such sequences in a transgenic host cell, and methods for their use. Also provided are organisms, cells and tissues prepared by a method of the invention. | 2012-07-26 |
20120192318 | Transformation system for Camelina sativa - In order to better aid consumers of prescription medicine and the like in efficient and rapid identification of the correct pill to be taken from among multiple containers, a novel group of articles of manufacture adapted for use with end-use prescription medicine containers at least includes a plurality of predetermined medicine purpose types corresponding to different types of medical or vitality purposes that underlying medicines are targeted to treat or address. Each article of manufacture is adapted to be coupled to an end-use, target prescription medicine container by an end-user or pharmacy function, and each article of manufacture at least includes an ideogram adapted to encourage a psychological association with, and identification of, the medicine expected to be placed in the target prescription medicine container to which the article of manufacture is adapted, and each article of manufacture is associated with a particular medicine purpose type. | 2012-07-26 |
20120192319 | Fabrication of a microcantilever microwave probe - A microwave probe having a metal tip on the free end of a microcantilever. In one embodiment, a pyramidal pit is isotropically etched in a device wafer of monocrystalline silicon. Oxidation may sharpen the pit. Deposited metal forms the metal tip in the pit and a bottom shield. Other metal sandwiched between equally thick dielectric layers contact the tip and form a conduction path along the cantilever for the probe and detected signals. Further metal forms a top shield overlying the conduction path and the dielectrically isolated tip and having equal thickness to the bottom shield, thus producing together with the symmetric dielectric layers a balanced structure with reduced thermal bending. The device wafer is bonded to a handle wafer. The handle is formed and remaining silicon of the device wafer is removed to release the cantilever. | 2012-07-26 |
20120192320 | CANTILEVER EXCITATION DEVICE AND SCANNING PROBE MICROSCOPE - Provided is a cantilever excitation device capable of preventing complication of resonance characteristics by a simple configuration. A cantilever excitation device ( | 2012-07-26 |
20120192321 | Interspecific tree named 'Country Cot' - A new and distinct variety of interspecific tree. The following features of the tree and its fruit are characterized with the tree budded on ‘Nemaguard’ Rootstock (non-patented), grown on Handford sandy loam soil with Storie Index rating 95, in USDA Hardiness Zone 9, near Modesto, Calif., with standard commercial fruit growing practices, such as pruning, thinning, spraying, irrigation and fertilization. Its novelty consist of the following combination of desirable features:
| 2012-07-26 |
20120192322 | Grapevine plant named 'M 48-42' - A new and distinct variety of diploid grapevine is provided which abundantly forms early-ripening juicy relatively large bunches of small substantially spherical berries that develop an intense black-purple coloration upon maturity. A propensity for high stenospermocarpic fruit production is displayed. Superior resistance to downy mildew and powdery mildew has been observed during evaluations to date. The plant is particularly well suited for the production of dried currants. The fruit also can be used in the table grape market or be used to make wine or grape juice. | 2012-07-26 |
20120192323 | Echinacea plant named 'Amazing Dream' - A new and distinct | 2012-07-26 |
20120192324 | Echinacea plant named 'Secret Passion' - A new and distinct | 2012-07-26 |
20120192325 | Echinacea plant named 'Satin Nights' - A new and distinct | 2012-07-26 |
20120192326 | Echinacea plant named 'Now Cheesier' - A new and distinct | 2012-07-26 |
20120192327 | Echinacea plant named 'Cranberry Cupcake' - A new and distinct | 2012-07-26 |
20120192328 | SEDUM PLANT NAMED 'POOL PARTY' - A new and distinct hybrid of | 2012-07-26 |