30th week of 2018 patent applcation highlights part 36 |
Patent application number | Title | Published |
20180209894 | Method And Apparatus For Inspection Of Corrosion And Other Defects Through Insulation - Detection of corrosion and other defects in piping is needed to prevent catastrophic pipeline failure. Sensors, systems and methods are provided to enable detection of such defects. These apparatus and methods are configured to characterize pipe protected by insulation and conductive weather protection. The sensors may utilize inductive and/or solid state sensing element arrays operated in a magnetic field generated in part by a drive winding of the sensor. Multiple excitation frequencies are used to generate the magnetic field and record corresponding sensing element responses. Relatively high excitation frequencies may be used to estimate the properties of the weather protection and sensor lift-off while lower frequencies may be used to detect internal and external pipe damage. Linear arrays may be moved to generate damage images of the pipe providing size and location information for defects. Two dimensional sensor arrays may be used to provide imaging without moving the sensor. | 2018-07-26 |
20180209895 | CHEMICAL APPLICATION DETECTION SYSTEM - A chemical application detection system has a drone with a GPS system and an ultraviolet detection device. The detection device senses a color hue of one or more additives combined with a chemical treatment applied to a field. The detected information is transmitted to a computer where the chemical treatment and location are displayed. | 2018-07-26 |
20180209896 | BINDING ASSAY SIGNAL ANALYSIS - Methods for determining a sample concentration of target entities in a sample, for example, determining a concentration of target antigens or antibodies in a blood sample or other biological sample. | 2018-07-26 |
20180209897 | DETECTING DEVICE, OPTICAL DETECTING APPARATUS, AND OPTICAL DETECTING METHOD - In optical detection, a technology of efficiently removing dust, dirt and the like adhering to an optical system member is provided. Provided is a detecting device used for an optical detecting apparatus including a main body provided with a sample holding unit which holds a sample, and a light transmitting portion facing at least a part of the sample holding unit and located on an optical path in the optical detecting apparatus at the time of installation on the optical detecting apparatus, and a cleaning unit arranged at a position opposed to a member on the optical path in the optical detecting apparatus. | 2018-07-26 |
20180209898 | VEGETATION INDEX CALCULATION METHOD AND VEGETATION INDEX CALCULATION DEVICE - A vegetation index calculation method is a method for calculating a vegetation index indicating a vegetation state in an earth's surface using an imaging unit and a flight vehicle, and the vegetation index calculation method includes an illumination spectrum acquisition step of acquiring a spectrum of illumination light with which the earth's surface is irradiated and a reflection spectrum acquisition step of acquiring a reflection spectrum of the earth's surface by the illumination light. The vegetation index calculation method also includes a calibration step of calibrating the reflection spectrum using the illumination spectrum and a step of calculating the vegetation index of the earth's surface based on a calibrated spectrum obtained through the calibration step. | 2018-07-26 |
20180209899 | METHODS AND APPARATUS FOR ON-CHIP DERIVATIVE SPECTROSCOPY - A derivative spectroscopy system for achieving a tunable resolution of 2 nm or less in resolving spectral components of an input optical signal is provided so as to estimate derivative spectra of the input optical signal based on the resolved spectral components. In the system, a first dispersive-element structure spectrally decomposes the input optical signal into subband signals. A second dispersive-element structure receives part or all of the subband signals and spectrally decomposes the received subband signals to plural spectral components. A material having a temperature-variant refractive index is used to build the second dispersive-element structure, enabling a shift of center wavelength of each spectral component as small as 2 nm of less upon changing a temperature of the second dispersive-element structure. By obtaining three spectral-component sets obtained at three different predetermined temperatures with the center-wavelength shift of 2 nm or less, first- and second-order derivative spectra are obtained with good accuracy. | 2018-07-26 |
20180209900 | SYSTEM AND METHOD OF INFERRING THE QUALITY LEVEL OF MEDICINES - A method and system of inferring a medicine quality level is provided. The method includes diluting the medicine with a solvent. Levels of absorption of UV light are measured at a plurality of predetermined wavelengths. The quality of the medicine is categorized based at least in part on an ELECTRE TRI process using the measured absorption levels. The category is displayed to an operator. | 2018-07-26 |
20180209901 | SYSTEM AND METHOD FOR EVALUATING FRUITS AND VEGETABLES - A system and method for non-destructively determining characteristics of a vegetable or fruit may include processing an image of the vegetable or fruit to produce image analysis results; analyzing light emitted by a Near Infrared Reflectance (NIR) device and reflected from the vegetable or fruit to produce reflection analysis results; and calculating at least one value that reflects at least one characteristic of the vegetable or fruit based on the image analysis results and based on the reflection analysis results. | 2018-07-26 |
20180209902 | APPARATUS AND METHOD FOR DETECTING A GAS USING AN UNMANNED AERIAL VEHICLE - A gas detection apparatus mountable to an unmanned aerial vehicle (UAV) comprises a transceiver module, a reflector module and an electronics module. The transceiver module comprises a laser emitter and a laser receiver; the laser emitter is tunable to emit a laser spectroscopy beam that can detect at least one target gas, and the laser receiver is configured to convert the laser spectroscopy beam into absorption spectroscopy measurement data. The reflector module comprises a reflective surface capable of reflecting the laser spectroscopy beam emitted by the laser emitter to the laser receiver. The transceiver and reflector modules are mountable on parts of the UAV such that the transceiver and reflector modules are spaced apart and the laser emitter and laser receiver have an unimpeded line of sight with the reflecting surface. The electronics module is communicative with the transceiver module and with a flight computer of the UAV, and comprises a gas detection program that determines a concentration of the target gas from the measurement data received from the transceiver module; when the determined concentration of the target gas meets or exceeds an alarm threshold, the program records the received measurement data and instructs the flight computer to execute a defined flight plan for the UAV. | 2018-07-26 |
20180209903 | MONITORING OPACITY OF SMOKE EXHAUSTED BY WOOD STOVE AND CONTROLLING WOOD STOVE BASED ON SAME - A wood stove monitoring and control device can include a mounting flange mountable to a chimney exhaust pipe of a wood stove. The device can include a ring removably mountable on top of the mounting flange, where the flange is suitably positioned vertically along the exhaust pipe so that the ring is positioned at least partially above an end of the exhaust pipe. The device includes an optical beam source disposed on the ring, and which generates and outputs an optical beam. The device includes an optical sensor positioned on the ring opposite the optical beam source to detect the optical beam output by the optical beam source as the optical beam passes through smoke exhausted by the wood stove through the exhaust pipe. The device can include a temperature probe disposed on the ring to measure a temperature of heat exhausted by the wood stove through the exhaust pipe. | 2018-07-26 |
20180209904 | LIGHTING DEVICE, AND APPARATUS AND SYSTEM INCORPORATING THE LIGHTING DEVICE - Alighting device includes: a light emitting device including a plurality of light emitting elements arranged in curve having a first curvature; and a honeycomb member having an extendable and contractible honeycomb structure, arranged in curve having a second curvature larger than the first curvature, in an emission direction of light emitted from the light emitting device. | 2018-07-26 |
20180209905 | SUPER-RESOLUTION MICROSCOPE - A super-resolution microscope includes an illuminator that irradiates illumination beams of colors of different wavelengths through an objective lens onto a sample while causing the illumination beams to overlap at least spatially and a detector that detects a signal beam generated by the sample through irradiation with the illumination beams. As the illumination beams, the illuminator irradiates first and second illumination beams onto the sample from the same direction. The first illumination beam includes multiple wavelengths or monochromatic light for inducing a nonlinear optical effect in the sample. The second illumination beam has a different wavefront distribution on a converging surface of the objective lens or a different spatial distribution of an electrical field vector than the first illumination beam and suppresses induction of the nonlinear optical effect. The detector detects a signal beam generated by the sample as a result of the nonlinear optical effect. | 2018-07-26 |
20180209906 | HYDROPHILIC COATINGS OF PLASMONIC METALS TO ENABLE LOW VOLUME METAL-ENHANCED FLUORESCENCE - The present invention provides for metallic structures comprising a sulfhydryl or amino-terminated hydrophilic coating to provide a layer of hydrophilic character on the surface of the metallic structures thereby allowing the use of low volumes of aqueous solvents of fluorophores that have the ability to “spread out” across the surfaces of the metallic structures and to provide for a more uniform surface coating of fluorophores attached to or near the metallic structures. | 2018-07-26 |
20180209907 | Target Biological Substance Analysis Method And Analysis System - An analysis method of a target biological substance for analyzing a tissue specimen with a fluorescence microscope is provided. The tissue specimen is stained with immunostaining reagents including different kinds of fluorescent nanoparticles. According to the analysis method, a luminance ratio of each of the immunostaining reagents for each of filter sets is calculated; and number of fluorescent bright points is measured in the tissue specimen for each of the filter sets for calculating number of fluorescent bright points for each of the immunostaining reagents based on the luminance ratio. | 2018-07-26 |
20180209908 | DEVICES AND METHODS FOR IMAGING BIOMOLECULES - The present disclosure provides devices and methods enabling the analysis of biomolecules. In some embodiments, the biomolecules may be DNA, RNA, protein, peptide, small molecule, catalyst, precursor, nucleotide, antibodies, or other biomolecules of interest. | 2018-07-26 |
20180209909 | DEVICE FOR COLLECTING SURFACE-ENHANCED RAMAN SCATTERING SPECTRUM USING FULL-APERTURE-ANGLE PARABOLIC MIRROR - A device for collecting surface-enhanced Raman scattering spectra using a full-aperture-angle parabolic mirror. The device is a small-sized ultra-sensitive SERS Raman spectroscopic enhanced probe and a spectrometer, a surface plasmon resonance (SPR) Raman spectroscopic probe and a spectrometer, a spectrum analyzer having triple functions of an SPR Raman/absorption dual-spectrum and refractive index, a flow particle Raman analysis/micro-fluidic Raman analysis probe and a spectrometer, a minimally invasive flexible lumen Raman spectroscopic probe and a spectrometer and a Raman intelligent surgical scalpel. An external reflective or internal reflective parabolic mirror at full aperture angle is adopted to collect Raman scattering systems and SERS substrates to ensure ultra-high sensitivity. A portable and hand-held Raman spectrometer would be widely applied to various trace analysis such as food safety and early-stage cancer screening, environmental safety screening and detection. | 2018-07-26 |
20180209910 | Inteferometric Sensor Basid on Slab Waveguide - The present invention provides a sensor having, one or more optical slab waveguides having one or more target regions. The target regions may interact with gas molecules or trap, entrain or capture one or more targets of interest. The optical slab waveguides are adapted to receive one or more input optical beams from one or more light sources to create a plurality of propagating optical waves in optical slab waveguide. The propagating optical waves interact with said one or more target regions to create an optical output wavefront that may be in the form of a diffraction pattern. The target regions may be functionalized with an antibody, polymer, cell, tissue, or biological material. | 2018-07-26 |
20180209911 | PH DISTRIBUTION MEASUREMENT IN A POROUS MATERIAL MICRO-STRUCTURE METHOD AND APPARATUS - A method and apparatus for pH distribution measurement in a porous material micro-structure is disclosed. In one embodiment, a method of measurement of pH distribution within the micro-structure of a porous material, such as cell, plant, fiber or cellulose material, paper or cultural object of porous materials (next material) is disclosed. The method comprises the steps of (in any order) preparing a microscopic sample of the porous material at a selected magnification; selecting an elementary measured area of the microscopic sample or microimage; microimaging the elementary measured area; measuring one or more pH characteristic parameters and pH from the elementary measured area, and measuring a correlation between the one or more characteristic optical parameters from the elementary measured area and the pH of from the elementary measured area to obtain a correlated microscopic pH value and a microscopic characteristic optical parameter value and their distribution within the porous material micro-structure. | 2018-07-26 |
20180209912 | INFRARED INK PRINT TESTING FOR MANUFACTURING - An assembly for testing an infrared (IR) ink print quality of an IR ink print area on an optical component includes a light source including an illuminated periphery and a dark interior, an IR camera having a field of view positioned to image the dark interior without imaging at least a portion of the illuminated periphery, and a component holder configured to hold the optical component between the IR camera and the light source such that IR light emitted from the portion of the illuminated periphery that illuminates the IR ink print area on the optical component is deflected into the field of view of the IR camera if the IR ink print area has defects but is not deflected into the field of view of the IR camera if the IR ink print area does not have defects. | 2018-07-26 |
20180209913 | SYSTEMS, METHODS, AND TEST KITS FOR ANALYTE VARIATION DETECTION - Systems, methods, and test kits for monitoring and detecting variation in an analyte level in a fluid sample from an individual variation using a uniquely determined analyte threshold value. In one implementation, luteinizing hormone is the monitored analyte and is compared with the determined threshold value to predict the onset of ovulation for the individual. | 2018-07-26 |
20180209914 | SYSTEM AND METHOD FOR DETERMINING AN IMPACT OF MANUFACTURING PROCESSES ON THE CALIPER OF A SHEET MATERIAL - A method for processing a plurality of sheet material includes receiving a plurality of sheets of material, transporting, via a transport mechanism, the plurality of sheets, one sheet at a time, past a first image capture device, obtaining, via a first image capture device, a first image of a first set of one or more of the plurality of sheets while being transported past the first image capture device, and determining, via at least one processor, a first caliper measurement of the first set of one or more of the plurality of sheets based on the first image of each of the first set. | 2018-07-26 |
20180209915 | ASYMMETRICAL MAGNIFICATION INSPECTION SYSTEM AND ILLUMINATION MODULE - An illumination module that includes a pair of anamorphic prisms that comprises a first anamorphic prism and a second anamorphic prism; wherein the pair of anamorphic prisms is configured to (a) receive a first radiation beam that propagates along a first optical axis, and (b) asymmetrically magnify the first radiation beam to provide a second radiation beam that propagates along a second optical axis that is parallel to the first optical axis; and a rectangular prism that is configured to receive the second radiation beam and perform a lateral shift of the second radiation beam to provide a third radiation beam; and a rotating mechanism that is configured to change an asymmetrical magnification of the pair of anamorphic prisms by rotating at least one of the first anamorphic prism and the second anamorphic prism. | 2018-07-26 |
20180209916 | METHODS FOR DEFECT INSPECTION, SORTING, AND MANUFACTURING PHOTOMASK BLANK - A photomask blank having a thin film on a transparent substrate is inspected for defects by irradiating inspection light to a surface region of the blank, collecting the reflected light from the irradiated region via an inspection optical system to form a magnified image of the region, extracting a feature parameter of light intensity distribution from the magnified image, and identifying the bump/pit shape of the defect based on the feature parameter combined with the structure of the thin film. The defect inspection method is effective for discriminating defects of bump or pit shape in a highly reliable manner. On application of the defect inspection method, photomask blanks having no pinhole defects are available at lower costs and higher yields. | 2018-07-26 |
20180209917 | OPTICAL INSPECTION SYSTEM FOR PRINTED CIRCUIT BOARD OR THE LIKE - An inspection system inspects points of interest on an item. A two-axis gimbal holds the item and is controlled to adjust an angle of incidence and angle of approach of a line of sight of an imaging device with respect to the point of interest. A Y-axis actuator adjusts a position of the imaging device along a Y-axis of the item, and an X-axis actuator adjusts a position of the imaging device along an X-axis of the item. A controller controls the gimbal, the Y-axis actuator and the X-axis actuator. Upon selecting a point of interest, angle of incidence, and angle of approach, the imaging device displays and/or captures an image, and the image can be inspected by a human inspector or automated inspection system. | 2018-07-26 |
20180209918 | OPTICAL INSPECTION SYSTEM FOR TRANSPARENT MATERIAL - A system and a method for inspecting a transparent object. The system may comprise a light source module; a collimating lens system; a sensor; a collector lens system for concentrating the sheet of light, passed through the object, in a plane of the sensor; and an optical element, the optical element being adapted to provide different focus ranges for the light portions emitted with different colors (intensity peak wavelengths). | 2018-07-26 |
20180209919 | WATER VAPOR OBSERVING SYSTEM - A water vapor observing system which is capable of observing water vapor regardless of a situation of an external system may be provided. The water vapor observing system may be configured to observe water vapor contained within atmospheric air, and include a transmission unit configured to transmit transmission waves, one of a reception unit configured to receive reflection waves caused by the transmission waves reflected on and returned from a stationary object as reception waves, and a reception unit disposed at a different position from the transmission unit and configured to receive the transmission waves as reception waves, and a relative water vapor amount calculating module configured to calculate a relative water vapor amount that is a relative value of water vapor with respect to a reference water vapor amount being a comparison target, based on the reception wave received by the one of the reception units. | 2018-07-26 |
20180209920 | WATER VAPOR OBSERVING APPARATUS - The purpose is to reliably calculate a water vapor amount at a given position. A water vapor observing apparatus may include a transmitting part (which may also be referred to as a transmitter circuitry) configured to transmit a first transmission wave and a second transmission wave having different frequencies, a receiving part (which may also be referred to as a receiver circuitry) configured to receive, as reception waves, reflection waves caused by the transmission waves reflected on and returned from a ground surface portion or a water surface after passing through water vapor, and an arithmetic processor configured to calculate an amount of the water vapor in a passing area of the transmission waves based on first reception information generated from a first reception wave obtained from the first transmission wave, and second reception information generated from a second reception wave obtained from the second transmission wave. | 2018-07-26 |
20180209921 | SYSTEMS AND METHODS FOR ASSAYING AN ELUATE OF A RADIONUCLIDE GENERATOR - A system for assaying an eluate includes a radiation detection device, a fluid handling system, and a connection interface. The radiation detection device includes a collection reservoir, and is adapted to measure a radioactive content of a sample within the collection reservoir. The fluid handling system includes a fluid supply line, a suction line, and a fluid discharge line, each connected to the collection reservoir. The connection interface connects a radionuclide generator to the collection reservoir via the fluid handling system. The fluid handling system is configured to generate a negative pressure within the collection reservoir via the suction line such that an eluate from the radionuclide generator is supplied to the collection reservoir via the fluid supply line. | 2018-07-26 |
20180209922 | DATA PROCESSING APPARATUS AND DATA PROCESSING METHOD FOR X-RAY EXAMINATION, AND X-RAY EXAMINATION SYSTEM PROVIDED WITH THE DATA PROCESSING APPARATUS - The type and/or properties of a substance is identified highly accurately regardless of the thickness of the substance. A data processing apparatus processes counts detected at each of pixels of a photo counting detector in each of a plurality of energy ranges of X-rays. The X-rays are radiated from an X-ray tube, and transmitted through an object. The apparatus calculates an image of the object based on the counts, and sets a region of interest on the image. The apparatus further removes, from the pixel, pixel information showing a background present in the region of interest, and calculates, pixel by pixel, inherent information inherent to the substance, based on the counts detected at each of the respective pixels in each of the energy ranges of the X-rays in the region of interest. The inherent information indicates a transmission characteristic inherent to the X-rays. | 2018-07-26 |
20180209923 | METHOD OF NEUTRON TOMOGRAPHY - A method of obtaining neutron tomography images of a workpiece ( | 2018-07-26 |
20180209924 | Defect Determining Method and X-Ray Inspection Device - The present invention provides an X-ray inspection device that detects a defect not on the basis of a change of an X-ray irradiation angle but on uniform determining criteria. As one embodiment for achieving the purpose, proposed below is an X-ray inspection device that is provided with: a detection element that detects a transmission X-ray, which has been emitted from an X-ray source and passed through a sample; and an arithmetic device, which forms a profile on the basis of output signals transmitted from the detection element, and which detects, using the profile, a defect included in the sample. The arithmetic device detects the defect on the basis of threshold setting corresponding to the visual field positions of the transmission X-ray. | 2018-07-26 |
20180209925 | METHOD AND SYSTEM FOR ANALYSIS OF OBJECTS - A spectroscopy method and system, the method comprising irradiating an object with a laser-accelerated particle beam and detecting photons emitted by the object as a result of the interaction between the laser-accelerated particle beam and the object. The system comprises a laser; a particle source, positioned at a distance from the object; and a spectrometer and a detector; wherein the particle source generates a laser-accelerated particle beam under irradiation by the laser; and the spectrometer and the detector detect photons emitted from the object under irradiation by the laser-accelerated particle beam. | 2018-07-26 |
20180209926 | HYDROGEN GAS SENSORS BASED ON NANOPARTICLE-DECORATED, PATTERNED CARBON NANOTUBE ROPES - Nanoparticle(NP)-decorated carbon nanotube (CNT) ropes used as sensing elements for hydrogen gas (H | 2018-07-26 |
20180209927 | REDUCTION-OXIDATION SENSOR DEVICE AND MANUFACTURING METHOD THEREOF - A reduction-oxidation sensor device and a manufacturing method thereof are provided. The reduction-oxidation sensor device includes a first electrode, at least one sensing structure and a second electrode. The first electrode is located on a substrate. The at least one sensing structure is located on the first electrode and the substrate. The at least one sensing structure includes a metal nanowire layer and a metal oxide layer. The metal nanowire layer is disposed on the first electrode and the substrate. The metal nanowire layer is wrapped by the metal oxide layer. The second electrode is located on the at least one sensing structure. | 2018-07-26 |
20180209928 | METHOD AND DEVICE FOR DETECTING DAMAGE RATE OF AN INNER COATING OF A DOWNHOLE OIL CASING - This disclosure provides a method and device for detecting the damage rate of an inner coating of a downhole oil casing. The method includes filling the oil casing with electrolyte, obtaining the well depth-detection current on a discharge electrode in a process of moving the discharge electrode from one end of the oil casing to the other end of the oil casing, and determining a well depth-damage rate state of the inner coating of the oil casing according to the well depth-detection current. This application can realize quantitative judgment for the damage rate of an inner coating of a downhole oil casing, resulting in rapid in detection speed, convenient and safe in operation, and low detection cost. | 2018-07-26 |
20180209929 | HUMIDITY DETECTOR - A humidity detector a humidity sensor detecting a relative humidity of an air inside a sensor case housing the humidity sensor. The humidity detector has an air volume obtaining section, a flow direction obtaining section, a setting section, and a correction section. The air volume obtaining section obtains air volume information correlated with an air volume of the air flowing around the humidity sensor. The flow direction obtaining section obtains flow direction information correlated with a flow direction of the air flowing around the humidity sensor. The setting section sets correction factors configuring a dynamic compensator based on the air volume information and the flow direction information. The dynamic compensator compensates for a response delay of the humidity sensor. The correction section corrects a detection value, which is detected by the humidity sensor, by using the dynamic compensator to obtain the relative humidity of the air. | 2018-07-26 |
20180209930 | DETECTION MODULE - The present invention relates to a detection module. It uses a polycrystalline film underneath a porous sensing film to simultaneously contact with hydrogen peroxide having various concentrations, and the surface potential of materials of the polycrystalline film and the porous sensing film will be changed and resulting in voltage shift, which can be used to determine the concentration of hydrogen peroxide. Accordingly, the present invention can be applied to screen hydrogen peroxide related diseases as an auxiliary tool. | 2018-07-26 |
20180209931 | Electrode and Use Thereof - The application relates to an electrode for use in the electrochemical detection of a target species, wherein the electrode has a planar surface disposed on which are probe molecules that are capable of binding selectively to the target species, wherein the electrode, prior to binding of the probe molecules with the target species, has an electron transfer resistance per area of the electrode of from 10 megaohms cm | 2018-07-26 |
20180209932 | Normalized Calibration Of Analyte Concentration Determinations - Biosensor system measurement devices used to determine the presence and/or concentration of an analyte in a sample include normalized calibration information relating output signal or signals the device generates in response to the analyte concentration of the sample to previously determined reference sample analyte concentrations. The measurement devices use this normalized calibration information to relate one or more output signals from an electrochemical or optical analysis of a sample to the presence and/or concentration of one or more analytes in the sample. The normalized calibration information includes a normalization relationship to normalize output signals measured by the measurement device of the biosensor system and at least one normalized reference correlation relating normalized output signals to reference sample analyte concentrations. | 2018-07-26 |
20180209933 | ION SENSOR WITH DIFFERENTIAL MEASUREMENT - The present invention concerns an ion sensor based on differential measurement, that by means of at least two ion-sensitive field-effect transistors, compares the concentration of certain ions in a solution to be measured with the concentration of certain ions in a reference solution contained in a micro-reservoir with a micro-channel. To do this, the micro-reservoir and the micro-channel cover at least the gate of one of the ion-sensitive field-effect transistors and make up a unit partially filled with a porous material that covers the entirety of the aforementioned gate and at least the base of the micro-channel. | 2018-07-26 |
20180209934 | Electrochemical Measuring Cell for Measuring the Content of Chlorine Compounds in Water - The invention relates to an electrochemical measuring cell for measuring the content of chlorine compounds in water, having an electrolyte chamber ( | 2018-07-26 |
20180209935 | CAPILLARY ELECTROPHORESIS DEVICE AND FOCAL POSITION ADJUSTMENT METHOD FOR THE SAME - An electrophoresis device includes a mounted reference capillary and a focused optical system. A 2D image of light containing autofluorescence and a 2D image of Raman-scattered light are obtained from the separation medium, and pattern data for autofluorescence and Raman-scattered light are obtained from these. An electrophoresis capillary is mounted in the electrophoresis device, pattern data for autofluorescence and Raman-scattered light is obtained in the same way at each of multiple different focal positions of the optical system, and the focal position of the optical system that best matches that of the reference capillary is used as the in-focus position. | 2018-07-26 |
20180209936 | ELECTROCHEMICAL MEASUREMENT DEVICE AND ELECTROCHEMICAL MEASUREMENT SYSTEM - An electrochemical measurement device is configured to measure an activity of a biological sample with a measuring liquid having conductivity. The device includes a plate having first and second wells provided therein, a measuring electrode disposed inside the first well, and a first placement portion provided configured to have the biological sample placed thereon. The first and second wells are provided in an upper surface at positions different from each other. The plate includes a wall separating a bottom surface of the first well from a bottom surface of the second well. The measuring electrode is provided on the bottom surface of the first well around the first placement portion. The second well is configured to have a counter electrode disposed therein. The first and second wells are configured to contain the measuring liquid therein. A portion of the measuring liquid contained in the first well is electrically connected to a portion of the measuring liquid contained in the second well. This electrochemical measurement device can perform electrochemical measurement in plural wells in a short time. | 2018-07-26 |
20180209937 | INTEGRATED CIRCUIT SENSOR AND SENSOR SUBSTRATE - An integrated circuit sensor that enables, regardless of a type of an inspection object, the inspection object and a front surface of the integrated circuit sensor to be in reliable contact with each other in a large region is provided. A through silicon via ( | 2018-07-26 |
20180209938 | APPARATUS, CONTROLLER, AND METHOD FOR INSPECTING A PART - Described herein is a method of inspecting a part for defects. The method includes applying an electromagnetic field to the part using a defect detection coil and one or more noise cancelation coils. The method also includes detecting feedback received in response to applying the electromagnetic field. The method includes adjusting settings corresponding to the one or more noise cancelation coils, in response to the feedback, to reduce electromagnetic noise. | 2018-07-26 |
20180209939 | SURFACE CHARACTERISTICS INSPECTION METHOD AND SURFACE CHARACTERISTICS INSPECTION APPARATUS FOR STEEL PRODUCT - To provide a surface characteristics inspection method of inspecting a heat treatment on a steel product subjected to a surface treatment in a nondestructive manner. A surface characteristics inspection apparatus is used which includes an alternating-current bridge circuit, an alternating-current power supply that supplies an alternating-current power to the alternating-current bridge circuit, and an evaluation device that evaluates the surface characteristics of a subject, which is a steel product subjected to a heat treatment, based on an output signal of the alternating-current bridge circuit. Coils of a reference detector and an inspection detector in the bridge circuit are energized to produce an alternating-current magnetism to induce an eddy current in a reference subject and the subject, respectively, and the electromagnetic characteristics of the subject obtained in the state where the reference detector detects a reference state is output as a first output signal. | 2018-07-26 |
20180209940 | FUEL DISPENSER WITH A FUEL ANALYZER - A fuel analyzer for a fuel dispensing environment is provided including an ultrasonic transmitter configured to transmit an ultrasonic signal through a volume of fuel, an ultrasonic receiver configured to receive the ultrasonic signal, and processing circuitry. The processing circuitry is configured to receive an indication of transmission of the ultrasonic signal from the ultrasonic transmitter, receive an indication of receipt of the ultrasonic signal from the ultrasonic receiver, determine a time of flight of the ultrasonic signal, and determine a fuel purity based on the time of flight of the ultrasonic signal. | 2018-07-26 |
20180209941 | DEVICE FOR DETECTING AND/OR MEASURING OUT AT LEAST ONE CHEMICAL COMPOUND, AND CHAMBER FOR FORMING SUCH A DEVICE - A device for detecting and/or measuring out one or more chemical compounds and a cell for forming the device, the device including at least one first and one second vibrating surface, each having a resonance frequency which varies when placed in presence of at least one chemical compound to be detected, and at least one first system actuating the first and the second vibrating surface to vibrate the first vibrating surface. The first actuating system is configured to generate a first mechanical wave remote from the first and the second vibrating surface, the first actuating system arranged in the device such that the first mechanical wave is transmitted to the first and the second vibrating surfaces to vibrate the first and the second vibrating surfaces. | 2018-07-26 |
20180209943 | APPARATUS, SYSTEM, AND METHOD FOR INSPECTING PARTS - Disclosed herein is an apparatus for inspecting structural integrity of a part. The apparatus includes a body and at least one sensor. The body is movable relative to the part. The at least one sensor is coupled to the body and includes a plurality of nanotubes configured to generate electrical signals when acted upon by an acoustic shockwave propagating through the part. The electrical signals are proportional to an intensity of the acoustic shockwave. | 2018-07-26 |
20180209944 | MECHANICAL SCANNING 3D ULTRASONIC TRANSDUCER - An ultrasonic transducer includes a housing, a driving device, and a detecting device. The housing internally includes an ultrasound transmitting/receiving unit, the housing sealing ultrasonic propagation liquid. The driving device includes a driving motor and an intermediate member. The driving device is configured to transmit a rotary driving force from the driving motor to swing the ultrasound transmitting/receiving unit. The detecting device includes a detecting member and is configured to detect an origin position serving as a reference in control of the swing of the ultrasound transmitting/receiving unit. The driving device is configured to transmit the rotary driving force to the intermediate member, extract a rotation of the intermediate member, decelerate the rotation of the intermediate member and transmit the rotation to the detecting member thereof in a route different from the driving device, and detect the rotation of the detecting member by a sensor to detect an origin position. | 2018-07-26 |
20180209945 | PRE-ANALYSIS TREATMENT METHOD FOR SAMPLE CONTAINING PLURALITY OF COMPONENTS WITH GREATLY DIFFERENT CONCENTRATIONS - A pre-analysis treatment method includes: a first retaining step of supplying, to a solid phase, each predetermined amount of the sample and a first solvent, and allowing a component at low concentration to be retained in the solid phase; a first washing step of supplying the first solvent to the solid phase and removing a component at high concentration from the solid phase; a second retaining step of supplying the sample in a smaller amount than the predetermined amount supplied in the first retaining step, and a second solvent to the solid phase, and allowing the component at high concentration to be retained in the solid phase; and an elution step of simultaneously extruding the components retained in the solid phase with an extrusion solvent. | 2018-07-26 |
20180209946 | GAS ANALYTE SPECTRUM SHARPENING AND SEPARATION WITH MULTI-DIMENSIONAL MICRO-GC FOR GAS CHROMATOGRAPHY ANALYSIS - The disclosure describes embodiments of an apparatus including a first gas chromatograph including a fluid inlet, a fluid outlet, and a first temperature control. A controller is coupled to the first temperature control and includes logic to apply a first temperature profile to the first temperature control to heat, cool, or both heat and cool the first gas chromatograph. Other embodiments are disclosed and claimed. | 2018-07-26 |
20180209947 | SPHERICAL POROUS HYDROXYAPATITE SORBENT AND METHODS THEREOF - Highly spherical sorbents of porous hydroxyapatite materials and methods of producing these sorbents are disclosed. The sorbents of the present invention have good mechanical stability and are useful as chromatography media for the separation of biomolecules, such as proteins and nucleic acids. | 2018-07-26 |
20180209948 | METHOD FOR INDOOR AIR ANALYSIS, AND SAMPLING ARRANGEMENT - A method for indoor air analysis, and a sampling arrangement are disclosed. The method includes taking a sample from indoor air in such a way that a surface is cooled to be so cold that water molecules of the indoor air undergo deposition on the surface, whereby frost is generated on the surface; defrosting the frost into water; and analysing the quality of the indoor air from the water. | 2018-07-26 |
20180209949 | SYSTEM AND METHOD FOR CROP HEALTH MONITORING - A method for monitoring crop health of a geographic region includes receiving an image comprising a set of image elements, the image corresponding to a time unit, mapping an image element of the set of image elements to a geographic sub-region of the geographic region, determining a geographic region performance value for the image element, determining a geographic region performance value change, and identifying a crop health anomaly based on the geographic region performance change and an expected geographic region performance value change. Determining the geographic region performance value for the image element can include determining a vegetative performance value for the image element, mapping the image element to a crop type, and normalizing the vegetative performance value. | 2018-07-26 |
20180209950 | FLUORESCENT COMPOUND, FLUORESCENT COMPOUND MIXTURE, FRESHNESS MARKER, FRESHNESS LABEL, AND SENSING SYSTEM - Disclosed herein is a fluorescent compound represented by the following general formula and having fluorescence characteristics that vary in the presence of a subject substance, | 2018-07-26 |
20180209951 | CHEMO-THERMO-PIEZORESISTIVE HIGHLY SENSING SMART CEMENT WITH INTEGRATED REAL-TIME MONITORING SYSTEM - The chemo-thermo-piezoresistive behavior of so-called “smart cement,” or cement modified with conductive fillers, is useful as a bulk sensor for monitoring the changes in the cement due to stresses, cracks, contamination, fluid loss, and temperature change that affect its performance. The smart cement utilizes a special conductive or semi-conductive filler and is useful as a bulk sensor that allows real-time monitoring of its properties. | 2018-07-26 |
20180209952 | NANOPORES WITH INTERNAL PROTEIN ADAPTORS - A method for detecting an analyte in a sample includes the steps of obtaining a nanopore sensor comprising a nanopore and a protein adaptor internalized in the lumen of the nanopore, adding a sample comprising an analyte to the cis side or the trans side of the nanopore, and measuring conductance across the nanopore. A change in conductance after adding the sample indicates the analyte is present in the sample and has bound to the protein adaptor. Nanopore sensors comprise a nanopore and a protein adaptor internalized in the lumen of the nanopore. The protein adaptor is a functional enzyme or ligand-binding protein. | 2018-07-26 |
20180209953 | TRANSLOCATION OF A POLYMER THROUGH A NANOPORE - Embodiments of the present disclosure are directed to methods, systems and devices, for analyzing the molecules. For example, in some embodiments, a system is provided which includes a first volume of conducting fluid, a second volume of conducting fluid, an orifice in communication with said first and second volumes of fluid, and means for applying an electric potential difference between said first and second volumes of fluid. In some such embodiments, a conjugate product is provided which comprises charged polymers each having attached thereto at least one first molecule for analysis, where the product carries a predetermined charge greater than the charge on the first molecule, and upon dissolving a product in the first volume of fluid, the product is directed into the orifice. | 2018-07-26 |
20180209954 | METHOD FOR IDENTIFYING TARGET CELL AND TARGET CELL IDENTIFICATION DEVICE - Provided are a robust and high throughput method for identifying a target cell and a target cell identification device. The method for identifying a target cell includes an image acquisition step of irradiating a specimen with a plurality of light rays having different wavelengths and acquiring a plurality of phase difference images of the specimen, a selection step of selecting a plurality of target cell candidates from the specimen based on a difference in absorption coefficients with respect to the plurality of light rays having different wavelengths, a brightness ratio acquisition step of acquiring brightness ratios between a central part and a peripheral part of each target cell candidate based on the plurality of phase difference images, and a sorting step of sorting a target cell and a non-target cell from the plurality of target cell candidates based on the brightness ratios. | 2018-07-26 |
20180209955 | METHOD AND SYSTEM FOR ASSESSING DRINKING BEHAVIOR - Method and system for self-assessment of drinking behavior. According to one embodiment, the method includes examining a transdermal alcohol response curve obtained from a drinking event, querying a user on their feelings of intoxication after or during the event, and using the combination of the objective measurement and subjective feelings of intoxication to provide an alert or status during subsequent drinking events. In so doing, the method mitigates at least some of the drawbacks associated with conventional alcohol monitoring devices by correlating an individual's reported feelings of intoxication with an objective transdermal measurement of alcohol. | 2018-07-26 |
20180209956 | HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies - Disclosed are methods, compositions, kits, and systems for identifying small-molecule drugs for treating cancer in a subject. The disclosed methods, compositions, kits, and systems may be utilized to identify small-molecule inhibitors of radiation sensitive protein 52 (RAD52) in order to treat cancer in a subject, such as breast cancer in a subject having a BRCA1-deficient, BRCA2-deficient, and/or PALB2-deficient phenotype by administering the identified small-molecule inhibitors to the subject. | 2018-07-26 |
20180209957 | MUSCLE CHIPS AND METHODS OF USE THEREOF - The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays. | 2018-07-26 |
20180209958 | MODULATION OF HEPATITIS B VIRUS REPLICATION - Presently disclosed is a method of modulating Hepatitis B virus (HBV) replication, by contacting the cell with at least one agent that modulates at least one factor from a specified group consisting of SNAI2, SOX7 and other factors, the screening of said agent and use thereof in a medicament for treating HBV infection or disease or condition associated with a HBV infection in a subject. In one preferred embodiment, the agent is one peptide derived from SOX7 or SNAI2 or stapled peptides thereof. As a separate invention, a method of identifying at least one factor that modulates replication of a virus is also disclosed. | 2018-07-26 |
20180209959 | METHODS AND COMPOSITIONS FOR CHARACTERIZATION OF GLIOBLASTOMA MULTIFORME TUMORS AND CANCER STEM CELLS - A method of characterizing a glioblastoma multiforme (GBM) stem cell (GSC), comprising culturing the GSC to provide a culture, contacting a first set of aliquots of the culture with individual compounds selected from a panel of compounds, identifying two or more of the selected compounds that cause more than a threshold level of cell death in the first set of aliquots, and characterizing the GSC as suitable for treatment with one or more combinations comprising the two or more identified compounds. A panel of anti-GBM chemotherapeutic compounds, the compounds selected by a method comprising surgically resecting the tumor, culturing a GSC derived from GBM tissue derived from a GBM tumor, contacting aliquots thereof with individual compounds selected from a panel of compounds, and identifying two or more of the selected compounds that cause more than a threshold level of cell death in the aliquots, thereby identifying the compounds. | 2018-07-26 |
20180209960 | Method of Determining, Identifying or Isolating Cell-Penetrating Peptides - The present invention provides a method of determining or identifying or isolating a cell-penetrating peptide (CPP) or analog or derivative thereof having cell-type selectivity and/or at least capable of passing through a Blood Brain Barrier of an animal subject. This invention also provides CPPs and analogs and derivatives thereof, such as those set forth in SEQ ID NOs: 1-27 of the Sequence Listing, and compositions comprising one or more of the CPPs, including conjugates in which a CPP or analog or derivative thereof is linked to a cargo molecule. The invention also provides methods for transporting cargo molecules across cell membranes to specific locations within cells, and for treating, preventing and/or diagnosing diseases that are treatable by a cargo molecule to which a CPP or analog or derivative of the invention is attached. The invention also provides tailored peptide libraries for use in identifying or isolating CPPs. | 2018-07-26 |
20180209961 | METHODS FOR DETERMINING DRUG EFFICACY USING CEREBLON-ASSOCIATED PROTEINS - Use of cereblon-associated proteins as biomarkers for clinical sensitivity to cancer, inflammatory diseases, and patient response to drug treatment. | 2018-07-26 |
20180209962 | SCREENING METHOD USING INDUCED NEURONS - An object of the present invention is to provide a method for screening for a prophylactic or therapeutic agent for tauopathy capable of blocking the propagation of tau-mediated neurodegeneration. | 2018-07-26 |
20180209963 | SCREENING METHOD FOR SELECTED AMINO-LIPID-CONTAINING COMPOSITIONS - The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-dimethylaminomethyl-[1-3]-dioxolane by screening for an effect of the agent on the liver of a model subject. | 2018-07-26 |
20180209964 | DEVICE AND METHOD FOR BIOLOGICAL SAMPLE COLLECTION AND INSPECTION - A device is described including a lid, a collection portion support, and a collection portion with a surface for receiving a biological sample, the lid includes a window and a window holder, the surface defines a first plane, the collection portion includes a first, a second, and a third position markers, each position marker indicates a center point marker, the center points define a second plane that has a line of intersection with the first plane, the device has an interior volume defined partially by the collection portion support, the collection portion, the window, and the window holder, the window allows visual inspection of the position markers, the collection portion support has a fluid inlet and a fluid outlet with a fluid path from the fluid inlet to the fluid outlet via the interior volume. | 2018-07-26 |
20180209965 | RESIN-PLATINUM COMPLEX AND USAGE THEREOF - This resin-platinum composite | 2018-07-26 |
20180209966 | FLUORESCENCE POLARIZATION IMMUNOASSAY METHOD FOR DETECTING CARBARYL - A fluorescence polarization immunoassay (FPIA) method for detecting carbaryl. The method includes the steps of mixing a sample to be tested, a fluorescent marker solution and an anti-carbaryl monoclonal antibody solution; incubating for carrying out a competitive reaction; determining a fluorescence polarization value of the resulting system; calculating the concentration of carbaryl in the sample to be tested according to a standard curve of fluorescence polarization values-carbaryl concentrations in carbaryl standard samples. According to the FPIA method for detecting carbaryl provided in the present invention, only the addition of a sample is required, and no separation and washing operations are needed. | 2018-07-26 |
20180209967 | COMPOSITIONS AND METHODS FOR DETECTING LOA LOA - Disclosed are methods of detecting the presence of detecting the presence of | 2018-07-26 |
20180209968 | DRUG DISCOVERY AND PROTEIN-PROTEIN INTERACTION ASSAY USING FLUORESCENT PROTEIN EXCHANGE - A novel assay for determining a molecular process using a fluorescent protein exchange assay, and a composition for use thereof, are provided. The assay provides first and second signalling proteins and an exchange protein, wherein the exchange protein interacts with the first signalling protein to form a complex, then introducing the second signalling protein, wherein in response to the molecular process, the exchange protein dissociates from the first protein and associates with the second protein. The change in signal in response to the exchange of the proteins is measured to indicate a molecular process. | 2018-07-26 |
20180209969 | Pseudomonas Aeruginosa Inhibitor Compounds - The invention relates to a method of identifying molecules which inhibit the virulence machinery of | 2018-07-26 |
20180209970 | IMMUNOASSAY METHOD AND IMMUNOCHROMATOGRAPHIC KIT - The present invention is intended to provide an immunoassay method that enables an immunoassay with high sensitivity at a high development rate without causing aggregation of insoluble carriers or non-specific reaction while improving test efficiency and reducing labor. The present invention relates to an immunoassay method that uses a test device, and the method includes: extracting an antigen of a detection target in an analyte with an extraction agent; and detecting the detection target with a detection reagent capable of binding the antigen. The extraction agent is a nitrous acid generated on the test device by a contact reaction between a nitrite salt and a heterocyclic compound having at least one skeleton selected from the group consisting of a cyclic ester, a cyclic amide, and a cyclic imide. | 2018-07-26 |
20180209971 | TEST STRIP FOR DIAGNOSTIC TESTING - A test strip includes a body defining a sample entry, a test area, and a cavity. The cavity is configured to transport a test sample from the sample entry to the test area. The test strip includes at least one passive mixing element within the cavity. The passive mixing element is configured to cause passive mixing of the test sample as the test sample is carried from the sample entry toward the test area. A test sample to be analyzed is introduced to the sample entry and at least a portion of the test sample is transported through the cavity to the test area. During transport, the test sample is passively mixed. | 2018-07-26 |
20180209972 | GENETICALLY ENCODED BIOSENSORS - The present disclosure provides, inter alia, genetically encoded recombinant peptide biosensors comprising analyte-binding framework portions and signaling portions, wherein the signaling portions are present within the framework portions at sites or amino acid positions that undergo a conformational change upon interaction of the framework portion with an analyte. | 2018-07-26 |
20180209973 | DETECTION OF AUTOANTIBODIES AGAINST THE TSH RECEPTOR - The invention relates to a bridge assay that can be used on an automatic diagnostic apparatus in order to detect anti-thyrotropin receptor autoantibodies, wherein the chimeric TSH receptor used comprises the extracellular portion of the chimeric TSH receptor and is N-terminally fused to a protein causing secretion of the chimeric TSH receptor from culture cells, and the anchored chimeric TSH receptor is immobilized on paramagnetic particles. | 2018-07-26 |
20180209974 | PREPARATION METHOD OF CRYTOCOCCUS NEOFORMANS CAPSULAR POLYSACCHARIDE GXM AS WELL AS GXM ANTIGEN IMMUNOASSAY KIT AND APPLICATION THEREOF - The present invention discloses a preparation method of | 2018-07-26 |
20180209975 | METHODS FOR USING EXOSOMES TO MONITOR TRANSPLANTED ORGAN STATUS - This present disclosure relates to the use of donor organ-derived microvesicles to monitor the status of a transplanted organ in a subject. Accordingly, this disclosure provides for methods and kits for isolating, purifying and/or identifying donor organ-derived microvesicles from a biological sample of a subject. In certain embodiments, a method for isolating, purifying and/or identifying donor organ-derived microvesicles includes obtaining a biological sample from the subject and isolating, purifying or identifying a donor organ-derived microvesicle from the biological sample by the detection of a protein specific for the donor. | 2018-07-26 |
20180209976 | REAL-TIME DETECTION OF INFLUENZA VIRUS - The present invention provides system and methods for detecting an analyte indicative of an influenza viral infection in a sample of bodily fluid. The present invention also provides for systems and method for detection a plurality of analytes, at least two of which are indicative of an influenza viral infection in a sample of bodily fluid. | 2018-07-26 |
20180209977 | Lp-PLA2 ASSAYS AND COMPOSITION WITH DETERGENT - Provided herein are methods, systems, and compositions for Lp-PLA2 detection assays that employ amounts of detergent to liberate all or nearly all of the Lp-PLA2 molecules from associated lipoprotein particles. In this regard, the true Lp-PLA2 concentration can be detected in a sample, which correlates better with known Lp-PLA2 activity assays. | 2018-07-26 |
20180209978 | UNIVERSAL, NON-INVASIVE, EARLY DETECTION SYSTEM FOR CANCERS - The present invention provides a universal system that detects cancer cells at all stages including early developmental stages as well as matured cancerous tumors. The system relates to monitoring the environment surrounding abnormally metabolizing cells, e.g., predominantly glycolytic cells, cancerous cells, precancerous cells, and/or cells with reduced mitochondrial Electron Transport Chain activity. Nanosensors detect chemical signatures of the organic compounds released by cancer cells into bodily fluids or to the air to detect cancerous or precancerous metabolisms in samples such as urine, saliva, sweat, blood or breath. Treatments provided in recognition of the signature metabolic changes occurring in cancer cells target the abnormal metabolism generally with special emphasis relating to changed mitochondrial metabolism and cell survivability. The treatments include, but are not limited to: therapeutic compositions and methods for treating, delaying, slowing or preventing one or more cancers. | 2018-07-26 |
20180209979 | METHOD FOR INDIVIDUALIZED CANCER THERAPY - An in vitro method for predicting a likelihood of an individual having a cancer to efficiently respond to an anti-cancer treatment, said method including the steps: of a) measuring the level of nuclear expression of TRF2 in a biopsy obtained from said individual, b) comparing the level obtained in step a) to a reference value, and c) determining the predicted likelihood of said individual to efficiently respond to said anti-cancer treatment from the comparison performed in step b). | 2018-07-26 |
20180209980 | BIOMARKERS FOR PREDICTING AND ASSESSING RESPONSIVENESS OF THYROID AND KIDNEY CANCER SUBJECTS TO LENVATINIB COMPOUNDS - Biomarkers are provided that are predictive of a subject's responsiveness to a therapy comprising lenvatinib or a pharmaceutically acceptable salt thereof (e.g., lenvatinib mesylate). The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities for a subject having cancer (e.g., thyroid cancer, kidney cancer), suspected of having cancer, or at risk of developing cancer. | 2018-07-26 |
20180209981 | WBP2 AS A CO-PROGNOSTIC FACTOR WITH HER2 FOR STRATIFICATION OF PATIENTS FOR TREATMENT - The present invention provides a method for the prognosis of overall survival, cancer recurrence or response to treatment for a patient suffering from cancer, the method comprising: (a) examining a sample from the patient to determine whether the patient is human epidermal growth factor receptor 2 (HER2) positive or negative; and (b) measuring WW domain-binding protein 2 (WBP2) levels in the patient's sample, wherein a result in step (a) and a result in step (b) provides a prognosis of overall survival, cancer recurrence or response to treatment for the patient. The present invention also provides a kit carrying out the method of the present invention. | 2018-07-26 |
20180209982 | COMPOSITIONS AND METHODS FOR PROSTATE CANCER ANALYSIS - The invention provides methods for diagnosing prostate cancer. The invention also provides methods for determining the prognosis and efficacy of STEAP1-ADC therapy in patients with prostate cancer, specifically metastatic castration resistant prostate cancer (mCRPC). | 2018-07-26 |
20180209983 | DE NOVO BINDING DOMAIN CONTAINING POLYPEPTIDES AND USES THEREOF - Provided herein are de novo binding domain containing polypeptides (DBDpp) that specifically bind a target of interest. Nucleic acids encoding the DBDpp, and vectors and host cells containing the nucleic acids are also provided. Libraries of DBDpp, methods of producing and screening such libraries and the DBDpp identified from such libraries and screens are also encompassed. Methods of making and using the DBDpp are additionally provided. Such uses include, without limitation, affinity purification, and diagnostic and therapeutic applications. | 2018-07-26 |
20180209984 | METHODS, SYSTEMS AND KITS FOR CYTOTOXIC CHEMOTHERAPY-BASED PREDICTIVE ASSAYS - The invention relates to methods, systems and kits for determining therapeutic effectiveness or toxicity of cancer-treating compounds that incorporate into or bind to DNA. In particular, the invention is directed to methods, systems and kits for predicting a patient's treatment outcome after administration of a microdose of therapeutic composition to the patient. The methods provides physicians with a diagnostic tool to segregate cancer patients into differential populations that have a higher or lower chance of responding to a particular therapeutic treatment. | 2018-07-26 |
20180209985 | REAGENTS FOR QUANTITATIVE MASS SPECTROMETRY - In some embodiments, a mass spectrometry tag may comprise a linker region, a mass balance region, and a reporter region. The mass spectrometry tag may be configured to fragment in a mass spectrometer via an energy dependent process to produce multiple reporter molecules. For example, the reporter region of the tag may be configured to produce at least two reporter molecules via fragmentation. In some embodiments, one or more regions of the tag may comprise at least one heavy isotope. In some such embodiments, the ability to fragment into multiple reporter molecules as well as the placement and/or number of heavy isotope(s) allows the mass spectrometry tag to be distinguished from other similar mass spectrometry tags. In some such embodiments, the ability to distinguish between tags having the same or substantially similar total mass to charge ratio and reporter region mass may allow the system to have a greater multiplexing capacity than conventional systems. | 2018-07-26 |
20180209986 | COMPOSITIONS AND METHODS FOR DETECTING CANCER CELLS IN A TISSUE SAMPLE - This invention is directed to methods for the facile and accurate identification of cancer cells in a tissue sample, such as a surgical field. In particular, the compositions and methods employ conjugates comprising pro-fluorescent fluorescein based moieties bound to folic or pteroic acid targeting moiety optionally through a linker. The pro-fluorescent fluorescein based moieties are non-fluorescent but capable of being rendered fluorescent by intracellular processes. The conjugates are employed to detect cancer cells that overexpress folic acid receptors thereby providing for differential accumulation of these conjugates in these cells. | 2018-07-26 |
20180209987 | LONG WAVELENGTH VOLTAGE SENSITIVE DYES - The disclosure provides for provides for water-soluble near-infra red (NIR) emissive compounds, processes of making the compounds thereof, and use of the compounds therein. | 2018-07-26 |
20180209988 | EARLY DETERMINATION OF PREGNANCY STATUS IN RUMINANTS - The present invention provides compositions and methods for detection schemes for ascertaining pregnancy status of an animal. The compositions and methods employ interferon-tau (IFNT) and/or antibodies specific for IFNT. Methods of the present invention detect the presence of IFNT in samples obtained from animals as an early indicator of pregnancy. Methods are provided to identify non-pregnant animals so that management decisions regarding rebreeding can be made earlier compared to existing approaches. | 2018-07-26 |
20180209989 | METHODS FOR ASSAYING PALMITOYL PROTEIN THIOESTERASE 1 AND TRIPEPTIDYL PEPTIDASE ACTIVITY IN DRIED BLOOD SPOTS FOR DETECTION OF NEURONAL CEROID LIPOFUSCINOSES IN NEWBORNS - The present disclosure provides assays for lysosomal enzymes, specifically palmitoyl protein thioesterase 1 (PPT1) and tripeptidyl peptidase 1 (TPP1), using, for example, tandem mass spectrometry. The assays involve the detection of enzymatic products obtained through the action of the lysosomal enzymes on new enzyme substrates, and can be used for quantitative enzyme activity measurements. The assays for the enzymes utilize a minimum steps for sample work up and can be run in a simplex format or in a duplex format for the detection of neuronal ceroid lipofuscinoses, or in a multiplex format with other mass spectrometry-based assays for screening of neuronal ceroid lipofuscinoses and other lysosomal storage disorders. | 2018-07-26 |
20180209990 | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE - The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more of C-C motif chemokine 16, C-C motif chemokine 14, and Tyrosine-protein kinase receptor UFO as diagnostic and prognostic biomarker assays in renal injuries. | 2018-07-26 |
20180209991 | ANALYSIS FOR ATHEROSCLEROSIS - The invention provides a process for analysis of the presence of atherosclerosis in a patient sample, and preferably identifies a form of atherosclerosis that correlates to an increased risk of the patient to develop rheumatoid arthritis (RA), connective tissue diseases, vasculitis, and/or spondyloarthritis, and/or myocardial infarction and/or apoplexy. | 2018-07-26 |
20180209992 | Methods and Compositions for Diagnosis of Inflammatory Liver Disease - The present disclosure provides methods and compositions that find use in facilitating a diagnosis of inflammatory liver disease in a subject. The methods and compositions generally involve detection of eotaxin-3 (E3) levels, either alone or with levels of eotaxin-1 (E1), and optionally, with levels of CCL22 and, further optionally, with levels of IL15. These levels can be used to facilitate a diagnosis of a liver disease of at least one of autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC), and/or to facilitate a differential diagnosis between AIH, PBC, and PSC. The methods and compositions of the present disclosure also find use in facilitating treatment decisions for a subject. | 2018-07-26 |
20180209993 | USES OF LP-PLA2 IN COMBINATION TO ASSESS CORONARY RISK - This invention relates to a method for assessing risk of Coronary Vascular Disease (CVD). Specifically, it relates to utilizing risk assessment from both Lipoprotein Associated Phospholipase A2 (Lp-PLA2) and C-reactive protein (CRP) in combination. In addition the invention relates to a method for assessing risk of Coronary Vascular Disease (CVD) in a patient with low to normal Low Density Lipoprotein Cholesterol (LDL) levels utilizing both LDL and Lipoprotein Associated Phospholipase A2 (Lp-PLA2). Moreover, the invention relates to the use of risk associated with Lp-PLA2, CRP and LDL in combination and specific ranges thereof to predict Coronary Vascular Disease. | 2018-07-26 |
20180209994 | Method for Treatment of Traumatic Brain Injury Targeting Aggregated Peptides - A method of preventing, alleviating or treating traumatic brain injury in an individual comprises administering to the individual a therapeutically effective and physiologically acceptable amount of an agent capable of reducing the amount of one or more aggregated forms of one or more peptides in the brain. An agent capable of reducing the amount of one or more aggregated forms of one or more peptides in the brain is suitable for use in preventing, alleviating or treating traumatic brain injury. A method for predication of the risk of an individual for complications after a traumatic brain injury comprises detecting one or more aggregated forms of one or more peptides prone to aggregate as a result of a traumatic brain injury event, in the brain of the individual, wherein an increased level of such aggregates in the brain indicates an increased risk for complications. | 2018-07-26 |