30th week of 2022 patent applcation highlights part 23 |
Patent application number | Title | Published |
20220234954 | VINYL ACETATE COPOLYMERS FOR HYDRAULICALLY SETTING CONSTRUCTION MATERIALS - Building construction materials containing inorganic hydraulically settable binder(s) and at least one protective colloid-stabilized polyvinyl acetate copolymer having specific ranges of vinyl acetate, vinyl chloride, and ethylene show improved adhesion under widely varying conditions when used in hydraulically setting construction materials, especially after thermal storage conditions. | 2022-07-28 |
20220234955 | Preparation of Hydrous Graphene Oxide for Use as a Concrete Admixture - An aqueous dispersion of graphene oxide is prepared in an additive process by subjecting graphitic carbon, such as biochar, in water or an aqueous solution to a high-shear environment in the presence of a dispersing agent to exfoliate graphene oxide. An intercalating agent may be added to facilitate exfoliation, and optionally neutralized. The graphitic carbon may be pre-processed by wet milling prior to exfoliation. The aqueous dispersion of graphene oxide may be used as a concrete admixture in a concrete composition. | 2022-07-28 |
20220234956 | CARBONATION CURING METHOD TO PRODUCE WET-CAST SLAG-BASED CONCRETE PRODUCTS - The present description relates to methods of producing a wet-cast slag-based concrete product particularly where the wet-cast slag-based concrete product is cast, pre-conditioned and cured with carbon dioxide inside a mould and/or inside a mould placed in a curing chamber. The wet-cast slag-based concrete product is optionally reinforced. | 2022-07-28 |
20220234957 | CERAMIC STRUCTURE AND SUPPORTING MECHANISM WHICH IS PROVIDED WITH SAID CERAMIC STRUCTURE - A ceramic structure of the present disclosure is provided with: a first member made of a single crystal of sapphire or an yttrium aluminum composite oxide; and a second member in contact with the first member, the second member being made of ceramic containing an aluminum oxide or an yttrium aluminum composite oxide as a principal component, wherein, of crystal grains constituting the second member, contact grains of the second member, which are grains in contact with the first member, include a first curved surface part that is convex toward the first member. | 2022-07-28 |
20220234958 | Dielectric Ceramic Composition and Ceramic Capacitor Using the Same - The present invention discloses a dielectric ceramic formula enabling one to obtain a multilayer ceramic capacitor by alternatively stacking the ceramic dielectric layers and base metal internal electrodes. The dielectric ceramic composition comprises a primary ingredient: | 2022-07-28 |
20220234959 | METHODS OF MAKING NANOPOWDERS, NANOCERAMIC MATERIALS AND NANOCERAMIC COMPONENTS - Methods of forming nanoceramic materials and components. The methods may include performing atomic layer deposition to form a plurality of nanoparticles, including forming a thin film coating over core particles, or sintering the nanoparticles in a mold. The nanoparticles can include a first material selected from a rare earth metal-containing oxide, a rare earth metal-containing fluoride, a rare earth metal-containing oxyfluoride or combinations thereof. | 2022-07-28 |
20220234960 | ELECTROCHROMIC DEVICE INCLUDING LITHIUM-RICH ANTI-PEROVSKITE MATERIAL - An electrochromic device includes a light transmissive first substrate, a working electrode disposed on the first substrate, a light transmissive second substrate facing the first substrate, a counter electrode disposed on the second substrate, and a lithium-rich anti-perovskite (LiRAP) material disposed between the first and second substrates. The LiRAP material includes an ionically conductive and electrically insulating LiRAP material. | 2022-07-28 |
20220234961 | METHOD OF MAKING A REFRACTORY ARTICLE - A method of making a refractory article is provided. The method includes: a) mixing a binder system, a refractory charge, and a second colloidal binder to form an aqueous slurry; b) casting the aqueous slurry into a mold; c) subjecting the mold containing the aqueous slurry to a temperature that is lower than a slurry casting temperature for a time sufficient to form a green strength article; and d) firing the green strength article at a temperature of at least 450° C. for a time sufficient to achieve thermal homogeneity, thereby forming a refractory article. Refractory articles made in accordance with the method have a unique combination of pore structure and mechanical properties. | 2022-07-28 |
20220234962 | FREEZE-CAST CERAMIC MEMBRANE FOR SIZE BASED FILTRATION - Provided herein are methods for making a freeze-cast material having a internal structure, the methods comprising steps of: determining the internal structure of the material, the internal structure having a plurality of pores, wherein: each of the plurality of pores has directionality; and the step of determining comprises: selecting a temperature gradient and a freezing front velocity to obtain the determined internal structure based on the selected temperature gradient and the selected freezing front velocity; directionally freezing a liquid formulation to form a frozen solid, the step of directionally freezing comprising: controlling the temperature gradient and the freezing front velocity to match the selected temperature gradient and the selected freezing front velocity during directionally freezing; wherein the liquid formulation comprises at least one solvent and at least one dispersed species; and subliming the at least one solvent out of the frozen solid to form the material. | 2022-07-28 |
20220234963 | Method for Making Moldable and Cuttable Composite Material for Magnetic Moment Calibration of Samples with Specific Shapes - A method for making moldable and cuttable composite material for magnetic moment calibration of samples with specific shapes is provided. The method is used to quantify a magnetic moment per unit weight from the moldable and cuttable composite material. The moldable and cuttable composite material is made by a non-magnetic matrix with superparamagnetic particles, paramagnetic particles, or ferromagnetic particles without anisotropy. Then, the moldable and cuttable composite material is shaped and tailored into calibration samples with specific shapes. The method provides a method for making calibration samples with the specific shapes, wherein the calibration samples are easily shaped and tailored to same or similar shapes and sizes as test samples. The method improves an original method for making a standard calibration sample, wherein the original method only used pure nickel ball or high purity palladium wire structure. | 2022-07-28 |
20220234964 | DIELECTRIC DRYING METHOD AND DIELECTRIC DRYING APPARATUS FOR CERAMIC FORMED BODIES, AND METHOD FOR PRODUCING CERAMIC STRUCTURES - A dielectric drying method for ceramic formed bodies includes drying a plurality of ceramic formed bodies placed side by side in a direction perpendicular to a conveying direction on upper surfaces of drying tables by conveying the ceramic formed bodies between electrodes of an upper electrode and a lower electrode, and applying a high frequency between the electrodes. In the direction perpendicular to the conveying direction of the ceramic formed body, a distance between the electrodes in two end regions between which a central region is interposed is shorter than a distance between the electrodes in the central region. | 2022-07-28 |
20220234965 | CALCIUM PHOSPHATE COATED WITH HUMIC ACID OR PHENOLIC POLYMER AND USES THEREOF - The present invention relates to a slow-releasing fertilizer composition and a composition for increasing plant growth and plant tolerance to salt stress which comprise, as an effective ingredient, hydroxyapatite or in mixture with a tricalcium phosphate obtained from chemical synthesis or thermal treatment of bones, coated with humic acid or a polymer of monomeric phenol. | 2022-07-28 |
20220234966 | FERTILIZING COMPOSITION COMPRISING A GLASS MATRIX - The present invention relates to a fertilizing composition comprising a glass matrix, wherein said glass matrix comprises: at least three forming oxides, wherein said at least three forming oxides are SiO | 2022-07-28 |
20220234967 | Oligomerization Process - The present invention concerns a process for oligomerizing an olefin feedstock to form an oligomerization product, and a method of controlling such an oligomerization process. The process comprises oligomerizing propylene to form a C | 2022-07-28 |
20220234968 | PROCESSES AND SYSTEMS FOR MAKING RECYCLE CONTENT HYDROCARBONS - Processes and systems for making recycle content hydrocarbons, including olefins, are provided that integrate a cracker unit with one or more other processing units. For example, in some cases, a fluidized catalytic cracking unit may be used to crack recycle content pyrolysis oil and the effluent from the FCC may be further processed in a conventional cracker unit, including its downstream separation zone, to provide recycle content hydrocarbon product stream. In other cases, a pyrolysis unit and cracking unit may be co-located and may share at least one utility, service group, boundary, conduit, energy exchange zone, and/or geographical area. | 2022-07-28 |
20220234969 | UPGRADING FUSEL OILS OVER DOPED ALUMINA - This present disclosure relates to a catalytic process for upgrading crude and/or refined fusel oil mixtures to higher value renewable 2-methyl-2-butene, via novel doped alumina catalysts. It was found that passing a vaporized stream of crude and/or refined fusel oils over doped alumina catalysts provides renewable 2-methyl-2-butene in high yields in a single step. Subsequent downstream purification of the reactor effluent results in a renewable 2-methyl-2-butene at competitive price and quality to fossil fuel derived 2-methyl-2-butene. | 2022-07-28 |
20220234970 | Preparation Method for Triphenylchloromethane - Disclosed is a preparation method for triphenylchloromethane, comprising the following steps: adding hydrochloric acid or a mixture of hydrochloric acid and Lewis acid to a mixture of triphenylmethanol and an organic solvent; stirring for reaction; removing the water layer after the completion of reaction to obtain an organic solution containing triphenylchloromethane. In the method, the conversion rate of triphenylmethanol is almost quantitative to be above 99%, and the content of triphenylchloromethane in the product obtained is above 99%. The operation is simple, and no waste gas is generated. Therefore, the method is environmentally friendly and suitable for industrialized production and can achieve better economic benefits. | 2022-07-28 |
20220234971 | CONVERSION OF CHLOROFLUOROROPANES AND CHLOROFLUROPROPENES TO MORE DESIRABLE FLUOROPROPANES AND FLUOROROPENES - A process is provided comprising contacting and reacting the compound CF | 2022-07-28 |
20220234972 | IRRADIATION PROCESS OF PRO VITAMIN D - The invention discloses an improved process for production of vitamin D3 from 7-dehydrocholesterol (7-DHC) and to a simple process for recovery unreacted 7-DHC for further reuse. The invention further describes a process for isolation and purification of Vitamin D3. | 2022-07-28 |
20220234973 | METHOD AND FACILITY FOR PRODUCING A TARGET COMPOUND - The invention relates to a method ( | 2022-07-28 |
20220234974 | SELECTIVE HYDROGENATION OF ALKYNOLS TO ALKENOLS IN THE PRESENCE OF A PHOSPHORUS COMPOUND - The present invention relates to a process of hydrogenating an alkynol selectively to an alkenol by hydrogen using a hydrogenation catalyst which is palladium supported on a carrier in the presence of an additive which is an organic phosphorus compound bearing either a phosphine or a phosphine oxide group and with the proviso that if the additive bears a phosphino group that the additive bears two or more phosphino groups. | 2022-07-28 |
20220234975 | BIOGAS CONVERSION TO MIXED ALCOHOLS - Some variations provide a process for producing mixed alcohols, comprising: purifying a biogas feedstock to generate a renewable natural gas stream comprising methane; introducing the renewable natural gas stream into a methane-to-syngas unit operated at effective conditions to convert the methane to a first syngas stream containing at least H | 2022-07-28 |
20220234976 | MICROWAVE-ASSISTED DECARBOXYLATION OF ORGANIC ACIDS IN HEMP MATERIALS - The present disclosure provides a method for decarboxylation of organic acids in hemp materials. The method includes placing hemp biomass in a container. The method further includes heating the hemp biomass using a microwave so that the hemp biomass receives between 100 J/g and 2,000 J/g, inclusive, total microwave energy. The method further includes decarboxylating the hemp biomass to form decarboxylated products. | 2022-07-28 |
20220234977 | Dinuclear Copper Catalyst for the Oxidation/Oxygenation of Hydrocarbons - The subject invention provides synthetic compounds, and compound complexes having catalytic activities towards oxidation or oxygenation, and/or dehydrogenation of various substrates comprising C—H bonds. The catalysts of the subject invention comprise a dinuclear Cu(I)/Cu(II) center that can convert between a resting state and a reactive species. The subject invention also provides methods of using such catalysts for the oxidation of substrates comprising C—H bonds, e.g., hydrocarbons, to synthesize chemicals for use as pharmaceuticals and industrial feedstock. | 2022-07-28 |
20220234978 | AN INTENSIFIED PROCESS OF SYNTHESIS OF DIALKYL ETHERS USING A STEP CONICAL REACTOR - The present invention relates to an intensification of the synthetic process for the preparation of dialkyl ether from alcohol by using a conical fixed bed reactor integrated with distillation coupled conical polishing reactor. | 2022-07-28 |
20220234979 | PROCESS FOR THE PURIFICATION OF EUGENOL AND NOVEL COMPOSITIONS COMPRISING EUGENOL - The present invention relates to a process for the purification of crude eugenol by distillation in the presence of at least one stabilizing compound. The process of the present invention may be operated industrially, exhibits improved properties, in particular in terms of process safety, and makes possible efficient separation of ortho-eugenol. The present invention also relates to compositions comprising eugenol. | 2022-07-28 |
20220234980 | PRODUCTION OF MALIC ACID USING TUBULAR AND STIRRED TANK REACTORS - A process for production of malic acid includes obtaining a feed that includes one or more of crude maleic anhydride, pure maleic anhydride, crude maleic acid, crude fumaric acid, pure maleic acid, pure fumaric acid, vent gas scrubber solutions from production of maleic anhydride, and vent gas scrubber solutions from production of phthalic anhydride. The feed is passed in a tubular reactor assembly to obtain a first product stream, which includes unreacted feed and malic acid. The feed is made to undergo hydration reaction in the tubular reactor assembly for a first predetermined time period, and further hydration of the first product stream is caused in a stirred tank reactor assembly for a second predetermined time period to obtain a final product stream, which includes the malic acid. | 2022-07-28 |
20220234981 | EXTRACTION AND PURIFICATION OF NATURAL FERULATE AND COUMARATE FROM BIOMASS - A process for a reactive extraction and subsequent purification of organic molecules from biomass comprises extracting one or more products from the biomass using an extraction solvent to solvate the products, contacting the biomass with a reactant during the extracting, recovering the one or more products, performing ultrafiltration to remove impurities from the one or more products to produce a filtered extract, extracting oils in the filtered extract using adsorption to produce a de-oiled extract, performing transesterification or hydrolysis on the de-oiled extract, and performing adsorptive purification on the ferulic acid, coumaric acid, ferulate, coumarate, or a combination thereof. The one or more products comprise extracted organic molecules comprising a ferulate or a coumarate, and the one or more products are separated from the biomass as a liquid extract. | 2022-07-28 |
20220234982 | IMPROVED METHOD FOR MANUFACTUIRING HIGH-PURITY ALKYL ACRYLATES - The invention relates to the manufacture of alkyl acrylates by direct esterification of acrylic acid by the corresponding alcohol. In particular, the invention relates to the use of a topping column equipped with a side draw-off making it possible to draw off a stream rich in acid impurities, such as β-hydroxypropionic acid and β-acryloyloxypropionic acid, during the distillation of the crude reaction mixture, in order to produce an acrylic ester meeting purity standards which are compatible with its use to prepare acrylic polymers. | 2022-07-28 |
20220234983 | KINETIC RESOLUTION REACTION OF A (1RS,2SR)-(2-HYDROXY-3,5,5-TRIMETHYL-3-CYCLOPENTENYL)METHYL CARBOXYLATE COMPOUND, A PROCESS FOR PREPARING OPTICALLY ACTIVE TRANS-alpha-NECRODYL ISOBUTYRATE, AND A PROCESS FOR PREPARING OPTICALLY ACTIVE gamma-NECRODYL ISOBUTYRATE - The present invention relates to a process for preparing a (1S,2R)-(2-hydroxy-3,5,5-trimethyl-3-cyclopentenyl)methyl carboxylate compound of the following general formula (S,R)-(2), wherein R | 2022-07-28 |
20220234984 | COMPOSITIONS AND METHODS COMPRISING RESVERATROL - The present technology relates to synthesis of resveratrol compositions, in particular to methods of synthesizing resveratrol salicylates such as those formed through the activation of resveratrol and salicylic acid, and cosmetic and pharmaceutical compositions comprising the same. | 2022-07-28 |
20220234985 | DIESTER STRUCTURE MONOMER, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF - The preparation method for the diester structure monomer includes the following steps: dissolving glycolate in a reaction solvent to prepare a glycolate solution; mixing the glycolate solution with triethylamine in a protective atmosphere, and cooling to form a mixture; and keeping the protective atmosphere unchanged, and adding the methacryloyl chloride to the mixture for esterification to generate a diester structure monomer. The diester structure monomer generated by the preparation method for the diester structure monomer has a long diester side chain and a group with a small volume and high acid sensitivity. As a result, a resin synthesized from the diester structure monomer has good adhesive force and film-forming property, high deprotection efficiency and plasticity, and the hardness and brittleness of the resin are improved. Moreover, the prepared diester acid protected structure monomer has the advantages of high yield, low by-product content and easy separation and purification. | 2022-07-28 |
20220234986 | PHENOL COMPOUND, RESIN COMPOSITION AND METHOD OF PRODUCING SAME, AND SHAPED PRODUCT - Provided is a phenol compound represented by general formula (I), shown below. In general formula (I), R | 2022-07-28 |
20220234987 | STYRYL CARBOXYLATE DERIVATIVES - Novel Styryl Carboxylate derivatives are provided which exhibit activity for the treatment of immunological diseases, inflammation, obesity, hyperlipidemia, hypertension, neurological diseases, and diabetes. | 2022-07-28 |
20220234988 | REACTIVE MESOGENS - Reactive mesogens (RMs), mixtures and formulations comprising RMs, polymers obtained from such RMs and RM mixtures, and the use of the RMs, RM mixtures and polymers in optical or electrooptical components or devices, like optical films for liquid crystal displays (LCDs). | 2022-07-28 |
20220234989 | THERAPEUTIC DNP DERIVATIVES AND METHODS USING SAME - The present invention includes DNP derivatives that are useful for preventing or treating a metabolic disease or disorder in a subject in need thereof. In certain embodiments, the subject is further administered at least one additional therapeutic agent. | 2022-07-28 |
20220234990 | METHODS OF SYNTHESIS OF (1R,2R,5R)-5-AMINO-2-METHYL-CYCLOHEXANOL HYDROCHLORIDE AND INTERMEDIATES USEFUL THEREIN - Provided herein are methods and intermediates for making (1R,2R,5R)-5-amino-2-methylcyclohexanol hydrochloride, which are useful for the preparation of compounds useful for the treatment of a disease, disorder, or condition associated with the JNK pathway. | 2022-07-28 |
20220234991 | GAS-PHASE PROCESS FOR THE CONVERSION OF GLYCOLALDEHYDE WITH AN AMINATING AGENT - A process for the conversion of glycolaldehyde with an aminating agent in the presence of hy-5 drogen and of a catalyst, wherein the conversion is carried out in the gas phase. | 2022-07-28 |
20220234992 | SYNTHESIS AND APPLICATION OF ALCOHOL AMINE WITH EXTENDED MAIN CARBON CHAIN - Synthesis and application of an alcohol amine with an extended main carbon chain are provided, belonging to the field of chemical building materials. Under the action of a catalyst, tertiary amine is subjected to a two-step substitution reaction, a hydrolytic reaction and a reducing reaction to obtain a novel alcohol amine (NAA). The novel alcohol amine as provided may have a better grinding aid effect than triethanolamine while is added into cement as a cement grinding aid, and thus has a wide application prospect. | 2022-07-28 |
20220234993 | MAKING ETHYLENEDIAMINETETRAACETIC ACID - Provided is a method of making ethylenediaminetetraacetic acid (EDTA) comprising the steps: (a) providing a reaction mixture (a) comprising ethylenediamine (EDA) and glycolonitrile (GN), wherein reaction mixture (a) comprises 0% to 0.1% by weight, based on the weight of reaction mixture (a), of any base having pKa of the conjugate acid (PKaH) of 13 or higher; (b) causing or allowing reaction mixture (a) to react to form a dinitrile (DN) compound; (c) bringing the DN into contact with aqueous solution of a base having pKaH of 11 or higher, and causing or allowing the resulting mixture to react to form a diacid compound (DA); (d) causing or allowing the DA to react, either sequentially or simultaneously, with additional GN to form products (Pd); (e) causing or allowing products (Pd) to react with a base having pKaH of 11 or higher, to form EDTA. Also provided is a composition comprising a diacid/dinitrile compound (DADN) wherein each —R has the structure: | 2022-07-28 |
20220234994 | METHODS OF SYNTHESIZING 4-VALYLOXYBUTYRIC ACID - The present disclosure is directed synthetic methods for the preparation of 4-valyloxybutyric acid. The synthetic methods described herein employ a diverse array of protecting group strategies and reaction conditions. Additionally, the present disclosure is directed to compounds useful as synthetic intermediates in the preparation of 4-valyloxybutyric acid. | 2022-07-28 |
20220234995 | COMPOUNDS AND METHODS FOR TREATMENT OF BACTERIAL INFECTIONS - This document discloses a novel class of compounds for inhibiting bacterial growth and treating bacterial infection. The compounds target a key step of the futalosine pathway and therefore are effective for the selective inhibition of certain bacterial species and genera with reduced side effect in comparison with conventional antibiotics. | 2022-07-28 |
20220234996 | Method for Producing (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylb- utanoyl]amino}phenyl)-3-cyclo-propylpropanoic Acid and the Crystalline Form Thereof for Use as a Pharmaceutical Ingredient - The present invention relates to a novel and improved process for preparing (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoic acid of the formula (I), to the compound of the formula (I) in crystalline form and to their use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular, cardiopulmonary and cardiorenal disorders. | 2022-07-28 |
20220234997 | Methods and Compositions for Pest Control - Methods and compositions for pest control, and more particularly for control of ants, e.g., of the subfamily Myrmicinae, using tyramides. | 2022-07-28 |
20220234998 | METHOD OF PREPARING DIISOCYANATE COMPOSITION - In the embodiments, an aqueous hydrochloric acid solution instead of hydrogen chloride gas and solid triphosgene instead of phosgene gas may be used in the process of preparing a diisocyanate from a diamine through a diamine hydrochloride. In addition, the embodiments provide processes for preparing a diisocyanate composition and an optical lens, which are excellent in yield and quality with mitigated environmental problems by controlling the size of the diamine hydrochloride composition, the b* value according to the CIE color coordinate of the diamine hydrochloride composition, or the content of water in the diamine hydrochloride composition within a specific range. | 2022-07-28 |
20220234999 | METHOD FOR CATALYTICALLY PRODUCING UREA - A process for preparing urea comprises preparing formamide based on carbon dioxide, hydrogen, and ammonia, forming methyl formate or ammonium formate as an intermediate in a catalytic reaction, and preparing urea by reacting the formamide and possibly ammonia in the presence of a catalyst. The source of carbon dioxide is a liquid laden with chemically and/or physically bound carbon dioxide and selected from a methanol phase or an aqueous ammonia solution obtained by gas scrubbing of a syngas for removing carbon dioxide using a scrubbing fluid. The scrubbing fluid can be a methanol phase, or carbon dioxide is desorbed from the scrubbing fluid and absorbed into a methanol phase to give a carbon dioxide-laden methanol phase that is then reacted as carbon dioxide-containing stream with a hydrogen-containing stream in the presence of a catalyst to form methyl formate. The methyl formate is reacted with an ammonia-containing stream to form formamide. | 2022-07-28 |
20220235000 | Trisazo Compounds for Ink-jet Printing - Novel trisazo compounds are disclosed. The compounds are well suited for the dyeing and printing of natural and synthetic materials, especially as recording liquids for inkjet printing. | 2022-07-28 |
20220235001 | PROCESS FOR THE PRODUCTION OF PEROXYESTERS - Process for the production of a peroxyester involving the reaction of an anhydride with an organic hydroperoxide, separation of the formed carboxylic acid, production of an anhydride from said carboxylic acid, and recycling of the anhydride within the process. | 2022-07-28 |
20220235002 | PROCESS FOR THE PRODUCTION OF DIACYL PEROXIDES - Process for the production of a diacyl peroxide involving the reaction of an anhydride with a peroxyacid, removal of the formed carboxylic acid, production of an anhydride from said carboxylic acid, and recycling of the anhydride within the process. | 2022-07-28 |
20220235003 | PROCESS FOR THE PRODUCTION OF DIACYL PEROXIDES - Process for the production of a diacyl peroxide involving the reaction of an anhydride with an aldehyde and oxygen, removal of the formed carboxylic acid, production of an anhydride from said carboxylic acid, and recycling of the anhydride within the process. | 2022-07-28 |
20220235004 | PARA ACYL SUBSTITUTED DIAZACYCLOHEXENE DERIVATIVES - Para-acyl substituted diazacyclohexenes, medical formulations thereof and methods for making and using the same. | 2022-07-28 |
20220235005 | FUNGICIDAL N-(PYRID-3-YL)CARBOXAMIDES - The present invention relates to the use as fungicides of compounds of formula (I) wherein the variables are defined as given in the description and claims. The invention further relates to the compounds I and composition for compounds of formula I. | 2022-07-28 |
20220235006 | PYRIDINE DERIVATIVES AS TMEM16A MODULATORS FOR USE IN THE TREATMENT OF RESPIRATORY CONDITIONS - Compounds of general formula (I), wherein R | 2022-07-28 |
20220235007 | COVALENT INHIBITORS OF EQUINE ENCEPHALITIS VIRUS - Embodiments and methods for a new class of potent non-peptidic covalent inhibitors of nsP2 cysteine protease that inhibit Venezuelan equine encephalitis virus's (VEEV) replication in neuroblasts are disclosed. More particularly, an acrylate and vinyl sulfone-based chemical series were investigated as promising starting scaffolds against VEEV and as inhibitors of the cysteine protease domain of VEEV's non-structural protein 2 (nsP2). The invention discloses compounds of Formula I and analogues for treatment of VEEV. | 2022-07-28 |
20220235008 | PLEUROMULIN 7-CHLORO-1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID ESTER WITH ANTIBACTERIAL ACTIVITY AND A METHOD OF PREPARING THE SAME - A compound with anti-drug resistant bacteria activity having the following formula (I): | 2022-07-28 |
20220235009 | STABLE CRYSTAL OF 4-OXOQUINOLINE COMPOUND - Provision of a stabilized crystal of 6-(3-chloro-2-fluorobenzyl)-1-[(S)-1-hydroxymethyl-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (compound A). A crystal of compound A, which shows a particular X-ray powder diffraction pattern of a characteristic diffraction peaks at diffraction angles 2θ(°) as measured by X-ray powder diffractometry. | 2022-07-28 |
20220235010 | SYNTHESIS METHOD FOR 1-METHYL-1H-INDAZOLE-6-CARBOXYLIC ACID - The present application provides a synthesis method for 1-methyl-1H-indazole-6-carboxylic acid. The synthesis method comprises: using 2-fluoro-4-bromobenzaldehyde and methylhydrazine as raw materials to obtain 6-bromo-1-methylindazole by means of an annulation reaction, and then performing a methyl formate reaction and a hydrolysis reaction, so as to obtain the 1-methyl-1H-indazole-6-carboxylic acid. The synthesis method provided in the present application can directly synthesize a 1-position methyl substituted indazole without isomers, thereby avoiding the problem that impurities are difficult to be removed in subsequent separation, thus improving the purity of a product. The yield of the annulation reaction can reach 85%. | 2022-07-28 |
20220235011 | PHTHALAZINONE COMPOUNDS AND USE THEREOF - Provided is a phthalazinone compound, or a racemate, steroisomer or pharmaceutically acceptable salt thereof; a pharmaceutical composition for the prevention or treatment of Sirt6-associated diseases, including as an active ingredient, a phthalazinone compound, or a racemate, steroisomer or pharmaceutically acceptable salt thereof; and a method for treating Sirt6-associated diseases including administering a phthalazinone compound, or a racemate, steroisomer or pharmaceutically acceptable salt thereof to a subject in need. | 2022-07-28 |
20220235012 | ACID ADDITION SALT OF PYRIMETHAMINE - Acid addition salt of pyrimethamine (5-4-chlorophenyl)-6-ethyl-2,4-pyrimidinediamine) and methane sulfonic acid, process for its preparation and pharmaceutical compositions comprising the acid addition salt are disclosed. | 2022-07-28 |
20220235013 | 2-METHYL-QUINAZOLINES - The present invention describes 2-methyl-quinazoline compounds of general formula (I), methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions. | 2022-07-28 |
20220235014 | PROCESS FOR THE PREPARATION OF HIGHLY PURE ERLOTINIB HYDROCHLORIDE - The present invention provides to an improved process for the preparation of highly pure Erlotinib hydrochloride of formula (I) | 2022-07-28 |
20220235015 | PRODUCTS OBTAINED BY THE CONVERSION OF GLYCOLALDEHYDE DERIVATIVES AND AMINATING AGENTS AND THEIR CONVERSION TO ETHYLENEAMINES AND ETHANOLAMINES - A process for the manufacture of ethyleneamines and ethanolamines, comprising the steps of (i) converting a glycolaldehyde derivative of formula (II), in which R | 2022-07-28 |
20220235016 | Functionalized Triazine Compounds, Compositions Comprising Such Compounds and Cured Fluoropolymer Articles - Described herein are compounds according to Formula (I) wherein Rf is a perfluorinated divalent group comprising 2 to 12 carbon atoms; and Z is selected from —CH═CH | 2022-07-28 |
20220235017 | FORMULATION OF METAXALONE - Dosage forms of metaxalone containing submicron particles of metaxalone and uses thereof are described. The submicron dosage forms have improved bioavailability compared to certain conventional metaxalone dosage forms. | 2022-07-28 |
20220235018 | METHODS USING HDAC11 INHIBITORS - The present invention provides methods and uses of inhibitors of histone deacetylase 11 (HDAC11) in the treatment of diseases and/or disorders, such as, for example, cell proliferative diseases. | 2022-07-28 |
20220235019 | NOVEL IMPROVED METHOD FOR SYNTHESIZING DIAMINOPHENOTHIAZINE COMPOUNDS - The present invention relates to chemical synthesis and purification. Specifically, the present invention relates to a novel and improved method of synthesizing high purity diaminophenothiazine compounds of Formula I, specifically Methylene Blue and its pharmaceutically acceptable salt or hydrates thereof. The present invention relates to an improved method of synthesizing Methylene Blue compound of higher purities than those achievable by using known methods of synthesis as per the requirements of the international pharmacopoeias like USP and EP. | 2022-07-28 |
20220235020 | EPOXY REACTIVE DILUENT AND MANUFACTURING METHOD THEREFOR - Provided is an epoxy reactive diluent, wherein the content of a compound represented by Formula 1 below is 85% by weight or more based on a total weight of an epoxy reactive diluent composition: | 2022-07-28 |
20220235021 | SOLAR CELL DYES FOR COPPER REDOX BASED DYE SENSITIZED SOLAR CELLS AND COMBINATIONS THEREOF - The present application discloses compounds and compositions, useful in the manufacture of dye-sensitized solar cells and other similar technology. | 2022-07-28 |
20220235022 | METHODS FOR PREPARING CANNABINOIDS BY BASE-PROMOTED DOUBLE-BOND MIGRATION - Disclosed is a method for converting a first cannabinoid into a second cannabinoid that is a regioisomer of the first cannabinoid. The method comprising contacting the first cannabinoid with: (i) a base having a pKb that is less than a critical pKb for the first cannabinoid; and (ii) a solvent system comprising a polar solvent such as dimethyl sulfoxide (DMSO), triethylamine (TEA), or a combination thereof. | 2022-07-28 |
20220235023 | IMPROVED METHODS FOR CONVERTING CANNABIDIOL INTO DELTA8-TETRAHYDROCANNABINOL - Disclosed herein a method for converting (cannabidiol) CBD into a composition comprising Δ | 2022-07-28 |
20220235024 | ACYLOXY SUBSTITUTED PHENYL DITHIANE DERIVATIVES - Para-acyl substituted diazacyclohexenes, medical formulations thereof and methods for making and using the same. | 2022-07-28 |
20220235025 | METHODS OF SYNTHESIZING SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS - The present disclosure provides methods of synthesizing a compound of Formula (P)-I. The method proceeds through several different pathways including several novel chiral separations, a Sonogashira coupling, a zinc mediated reductive cyanation, as well as through various halide containing intermediates. Also disclosed is the multi-kilogram preparation of several novel intermediates. | 2022-07-28 |
20220235026 | TRIAZOLE CARBOXYLIC ACIDS AS LPA ANTAGONISTS - The present invention provides compounds of Formula (I), or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors. | 2022-07-28 |
20220235027 | CYCLOBUTYL CARBOXYLIC ACIDS AS LPA ANTAGONISTS - The present invention provides compounds of Formula (I): (I), or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors. | 2022-07-28 |
20220235028 | NOVEL SUBSTITUTED TETRAHYDROQUINOLIN COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS - Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder. | 2022-07-28 |
20220235029 | CRYSTAL FORM OF C-MET/AXL INHIBITOR - A crystal form and a salt form of a uracil compound acting as a c-MET/AXL inhibitor and a preparation method therefor, specifically relating to the crystal form and the salt form of the compound shown in formula (I), and also comprising an application of the crystal form and the salt form in the preparation of drugs for the treatment of tumours. | 2022-07-28 |
20220235030 | SELECTIVE HISTAMINE H3 ANTAGONIST ACID ADDITION SALTS AND PROCESS FOR THE PREPARATION THEREOF - The present invention relates to physically and chemically stable salts of the selective histamine preceptor antagonist compound of 1-[4-(4-{3-[(2R)-2-methyl-pyrrolidin-1-yl]-propoxy}-phenoxy)-piperidin-1-yl]-ethanone of formula (1) and/or polymorphs thereof and/or hydrates/solvates thereof, the process for the preparation thereof, pharmaceutical compositions comprising them, and for use in the treatment and/or prevention of conditions requiring the modulation of histamine H | 2022-07-28 |
20220235031 | PROCESSES FOR PREPARING AMINOPYRIMIDINE COMPOUNDS - Provided herein are improved processes for preparing aminopyrimidine compounds of Formula (I). The disclosed processes advantageously proceed through a β-diketoester intermediate of Formula (A) and avoid the direct linking of a pyrimidine and phenyl moieties. The disclosed methods significantly increase yield of the desired compounds and simplifies the synthetic route. | 2022-07-28 |
20220235032 | BISHETEROCYCLIC CARBONYL SUBSTITUTED DIHYDROPYRAZOLE COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF - A substituted dihydropyrazole compound as shown in formula I, which compound has a selective inhibitory effect on RIPK1, and a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof, wherein the definition of each group in the formula is detailed in the description. In addition is a pharmaceutical composition containing the compound, and the use thereof in the preparation of a drug for treating RIPK1-related diseases or conditions. | 2022-07-28 |
20220235033 | FACTOR XI ACTIVATION INHIBITORS - The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XI activation inhibitors. | 2022-07-28 |
20220235034 | SELECTIVE HISTAMINE H3 RECEPTOR ANTAGONISTS FOR TREATING AUTISM SPECTRUM DISORDER - The present invention relates to the selective histamine H3 receptor antagonists/inverse agonists 1-[4-(4-{3-[(2R)-2-methylpyrrolidin-1-yl]-propoxy}-phenoxy)-piperidin-1-yl]-ethan-1-on, its pharmaceutically acceptable salts, derivatives, pharmaceutical compositions, active metabolites and combinations for use in the treatment of symptoms of autism spectrum disorder (ASD). | 2022-07-28 |
20220235035 | TYK2 INHIBITORS AND USES THEREOF - Described herein are compounds that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation. | 2022-07-28 |
20220235036 | 1-PHENYL-5-AZINYLPYRAZOLYL-3-OXYALKYL ACIDS AND THEIR USE FOR CONTROLLING UNWANTED PLANT GROWTH - What are described are compounds of the general formula (I) and agrochemically acceptable salts thereof | 2022-07-28 |
20220235037 | CRYSTALLINE FORMS OF A MAGL INHIBITOR - Described herein is the MAGL inhibitor 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)piperazine-1-carboxylate, including crystalline forms and pharmaceutically acceptable salts and solvates thereof. | 2022-07-28 |
20220235038 | SUBSTITUTED BENZENECARBOXAMIDES AS IL-17A MODULATORS - The disclosure herein provides compounds and pharmaceutical compositions of the structure of Formula I: | 2022-07-28 |
20220235039 | CRYSTALLINE SALT FORMS OF 6-(CYCLOPROPANECARBOXAMIDO)-4-((2-METHOXY-3-(1-METHYL-1H-1,2,4-TRIAZOL-3-- YL)PHENYL)AMINO)-N-(METHYLD3) PYRIDAZINE-3-CARBOXAMIDE - Disclosed are crystalline salt Forms C and D of 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide. Form C is a MSA salt and Form D is a sulfate salt of Compound (I). Characterization data for the Forms are disclosed. | 2022-07-28 |
20220235040 | ISOXAZOLE CARBOXYLIC ACIDS AS LPA ANTAGONISTS - The present invention provides compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors. | 2022-07-28 |
20220235041 | COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS - Disclosed are dihydroisoxazole compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, E, and R | 2022-07-28 |
20220235042 | Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 Inhibitors - Some embodiments of the invention include inventive compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which can be used for treating, for example, certain diseases. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as head and neck squamous cell carcinoma (HNSCC), cancer, blood disorders, etc.). Additional embodiments provide synergistic combinations of a BCL2 inhibitor with an IRAK inhibiting compound, and methods of using same. | 2022-07-28 |
20220235043 | SUBSTITUTED SULFONAMIDE PYRROLOPYRIDINES AS JAK INHIBITORS - The present invention relates to new sulfonamide pyrrolopyridine compounds and compositions useful in the treatment of JAK-mediated conditions having the structures of Formula (I), wherein the R groups are as defined in the detailed description. Methods of inhibition of JAK kinase activity in a human or animal subject are also provided. Exemplary indications treated by inhibition of JAK kinase activity include, but are not limited to, inflammatory bowel disease, Crohn's disease, ulcerative colitis, irritable bowel syndrome, and Celiac disease. | 2022-07-28 |
20220235044 | METHOD FOR SYNTHESIZING 1,7-NAPHTHYRIDINE DERIVATIVES - The invention discloses a method for synthesizing 1,7-naphthyridine derivatives, which relates to the technical field of synthesizing pharmaceutical intermediates and organic chemical intermediates, wherein the method includes: (1) 2-chloro-3-amino-pyridine being used as Compound I as a starting material, and protecting an amino group to prepare Compound II; (2) the Compound II reacting with an aldehydation reagent under alkaline conditions to obtain Compound III; (3) cyclizing the Compound III with acrylate compounds under the action of Lewis acid to prepare compound IV. | 2022-07-28 |
20220235045 | SOLID STATE FORMS - The present invention provides a crystalline form and stable salts of 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(2-propanyl)-3-pyridinyl)-4-((2S)-2-methyl-4-(2-propenoyl)-1- piperazinyl)pyrido[2,3-d]pyrimidin-2(1H)-one, including several hydrochloride salt forms, phosphate salt form, mesylate salt form, and solid state forms thereof, pharmaceutical compositions, and methods of treating a disease mediated by KRAS G12C inhibition. | 2022-07-28 |
20220235046 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 - An object of the invention is to provide compounds as selective JAK1 inhibitor, a process for preparation of the inhibitors, a composition containing the compounds and utility of the compounds. | 2022-07-28 |
20220235047 | A MEDICAMENT FOR TREATING MYCOBACTERIAL INFECTION CHARACTERIZED BY COMBINING A CYTOCHROME bc1 INHIBITOR WITH CLARITHROMYCIN OR AZITHROMYCIN AND CLOFAZIMINE - The present invention relates to novel combinations. The invention also relates to such combinations for use as pharmaceuticals, for instance in the treatment of bacterial diseases, including diseased caused by pathogenic mycobacteria such as non-tuberculosis mycobacteria. In particular, the present invention relates to a medicament, characterized in that a compound having a cytochrome bc1 inhibitory activity, or its pharmaceutically acceptable salt, is combined with clarithromycin or azithromycin, and clofazimine, or their pharmaceutically acceptable salts. | 2022-07-28 |
20220235048 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF DISEASES - The present invention discloses compounds according to Formula I: | 2022-07-28 |
20220235049 | SUBSTITUTED PYRROLO [2, 3-b] PYRIDINE AND PYRAZOLO [3,4-b] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS - Provided are certain BTK inhibitors, pharmaceutical compositions thereof, and methods of use thereof. | 2022-07-28 |
20220235050 | ESTROGEN RECEPTOR MODULATORS - Compounds of Formula (I) are estrogen receptor alpha modulators, where the variables in Formula (I) are described in the disclosure. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions that are estrogen receptor alpha dependent and/or estrogen receptor alpha mediated, including conditions characterized by excessive cellular proliferation, such as cancer. | 2022-07-28 |
20220235051 | DI-FLUORO AZEPANES AS HBV CAPSID ASSEMBLY MODULATORS - Disclosed are compounds, compositions and methods for treating of diseases, syndromes, conditions, and disorders that are affected by the modulation of CAM1. Such compounds are represented by Formula (I) as follows: | 2022-07-28 |
20220235052 | PURINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS - The present invention relates to purine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections. | 2022-07-28 |
20220235053 | TLR7 AGONIST FOR TREATING COLORECTAL CANCER AND PHARMACEUTICAL COMBINATION THEREOF - Disclosed are a compound of formula I as a toll-like receptor 7 (TLR7) agonist or a pharmaceutically acceptable salt thereof for treating colorectal cancer, a pharmaceutical combination for treating colorectal cancer comprising the TLR7 agonist and a tyrosine kinase inhibitor, and the use of the compound of formula I or the pharmaceutically acceptable salt thereof and the pharmaceutical combination for treating colorectal cancer. | 2022-07-28 |