30th week of 2022 patent applcation highlights part 26 |
Patent application number | Title | Published |
20220235254 | REFRIGERANT COMPOSITIONS FOR REFRIGERANT COMPRESSOR SYSTEMS - A refrigeration system, including a low back pressure (LBP) hermetic reciprocating compressor and a refrigerant composition. The refrigerant composition includes difluoromethane (R-32), and 2,3,3,3-tetrafluoropropene (R-1234yf). | 2022-07-28 |
20220235255 | FLUORINE SUBSTITUTED UNSYMMETRICAL ETHERS, AND COMPOSITIONS, METHODS AND USES INCLUDING SAME - Compositions and methods comprising one or more compounds according to Formula I: | 2022-07-28 |
20220235256 | Compositions Comprising Phase Change Materials and Methods of Making the Same - In one aspect, compositions are described herein. In some embodiments, a composition comprises a phase change material, a hydrophobic sorption material, and a viscosity modifier. In some embodiments, a composition comprises a foam and a latent heat storage material dispersed in the foam, the latent heat storage material comprising a phase change material and a hydrophobic sorption material. | 2022-07-28 |
20220235257 | SYNTHETIC FUNCTIONALIZED ADDITIVES, METHODS OF SYNTHESIZING, AND METHODS OF USE - Some embodiments of the present disclosure are directed to synthetic functionalized additives, which may comprise a layered magnesium silicate. The present disclosure is also directed to drilling fluids that may comprise an aqueous base fluid and a synthetic functionalized additive. The present disclosure is further directed to methods for producing drilling fluids. | 2022-07-28 |
20220235258 | Slurry Design Process - Methods of wellbore cementing are provided. A method of generating a wellbore treatment fluid may include: classifying a plurality of solid particulates using correlations; calculating a reactive index and/or a water requirement for at least one of the solid particulates; and selecting two or more solid particulates from the plurality of solid particulates to create a wellbore treatment fluid. | 2022-07-28 |
20220235259 | REACTIVE POLYMERIC LOST CIRCULATION MATERIALS - Compositions and methods involving polyvalent cation reactive polymers for use as lost circulation materials in subterranean treatment operations are provided. In some embodiments, the methods include forming a treatment fluid including a base fluid, a source of a polyvalent cation, a polyvalent cation reactive polymer, and an acid precursor; introducing the treatment fluid into a wellbore penetrating at least a portion of a subterranean formation; and allowing the treatment fluid to at least partially set. | 2022-07-28 |
20220235260 | DUAL CATION HYDRATE INHIBITORS - Dual cation hydrate inhibitor compositions and methods of using such compositions to, for example, inhibit the formation of gas hydrate agglomerates are provided. In some embodiments, such methods include introducing a hydrate inhibitor composition into a fluid, wherein the hydrate inhibitor composition includes at least one compound having the structural formula: | 2022-07-28 |
20220235261 | SYSTEM AND METHOD FOR UTILIZING OOLITIC ARAGONITE AS A PROPPANT IN HYDRAULIC FRACKING - A system for utilizing oolitic aragonite as a proppant in hydraulic fracking is provided. The system includes a proppant storage tank including a stockpile of the oolitic aragonite. The system further includes a proppant pumping unit operable to pump the oolitic aragonite from the proppant storage tank, through an underground shaft, and into an underground fracture proximate to the underground shaft. | 2022-07-28 |
20220235262 | MOLECULAR SWITCHES IN POROUS NETWORKS - This invention relates to materials and to films comprising molecular photoswitches. The films exhibit excellent photoswitchable properties in the dry state. This invention is also related to processes of making the materials and the films and to uses of the films. The invention also relates to devices and systems comprising the films of this invention. | 2022-07-28 |
20220235263 | METHODS FOR OBTAINING AN N-TYPE DOPED METAL CHALCOGENIDE QUANTUM DOT SOLID-STATE ELEMENT WITH OPTICAL GAIN AND A LIGHT EMITTER INCLUDING THE ELEMENT, AND THE OBTAINED ELEMENT AND LIGHT EMITTER - The present invention relates to a method for obtaining an n-type doped metal chalcogenide quantum dot solid-state element with optical gain for low-threshold, band-edge amplified spontaneous emission (ASE), comprising: —forming a metal chalcogenide quantum dot solid-state element, and —carrying out an n-doping process on its metal chalcogenide quantum dots to at least partially bleach its band-edge absorption, which comprises: —a partial substitution of chalcogen atoms by halogen atoms, in the metal chalcogenide quantum dots, and/or —a partial aliovalent-cation substitution of bivalent metal cations by trivalent cations, in the metal chalcogenide quantum dots; and —providing a substance on the metal chalcogenide quantum dots, to avoid oxygen p-doping. The present invention also relates to the obtained n-type doped metal chalcogenide quantum dot solid-state element, a method for obtaining a light emitter with that n-type doped metal chalcogenide quantum dot solid-state element, and the obtained light emitter. | 2022-07-28 |
20220235264 | SEMICONDUCTOR NANOPARTICLE COMPLEX, SEMICONDUCTOR NANOPARTICLE COMPLEX DISPERSION LIQUID, SEMICONDUCTOR NANOPARTICLE COMPLEX COMPOSITION, SEMICONDUCTOR NANOPARTICLE COMPLEX CURED FILM, AND PURIFICATION METHOD FOR SEMICONDUCTOR NANOPARTICLE COMPLEX - Provided is a semiconductor nanoparticle complex in which a ligand is coordinated to a surface of a semiconductor nanoparticle. The semiconductor nanoparticle includes In and P, the ligand includes a mercapto fatty acid ester represented by the following general formula, and the mercapto fatty acid ester has an SP value of 9.30 or less. | 2022-07-28 |
20220235265 | LIGHT-EMITTING ELEMENT - A light-emitting element includes a hole transport layer between a light-emitting layer and an anode, the hole transport layer containing either a metal oxide of (NiO) | 2022-07-28 |
20220235266 | LIGHT EMITTING ELEMENT WITH EMISSIVE SEMICONDUCTOR NANOCRYSTAL MATERIALS AND PROJECTOR LIGHT SOURCE BASED ON THESE MATERIALS - Active materials for light emitting elements useful for light source apparatus and projector devices and provided. In particular, a light emitting element includes emissive semiconductor nano(crystal)material(s) (NC) and high-refractive index material. Further, a light source apparatus includes at least one light emitting element according to the present disclosure. The present disclosure also relates to a projector device, including a light source apparatus, including at least one light emitting element according to the present disclosure. Moreover, the present disclosure relates to methods of obtaining respective semiconductor nano(crystal)material (NC) films. | 2022-07-28 |
20220235267 | NON-PHOSPHORIC ACID-BASED SILICON NITRIDE FILM ETCHING COMPOSITION AND ETCHING METHOD USING THE SAME - A non-phosphoric acid-based silicon nitride film etching composition includes 5 to 50 wt % of an organic acid-based chelating agent including an organic phosphonic acid group, a carboxylic acid group, or a combination thereof, based on a total weight of the etching composition. The etching composition for pressurization suppresses etching a silicon oxide film and selectively etches a silicon nitride film in a vertically laminated structure in which both the silicon nitride film and the silicon oxide film are exposed to a surface or the silicon nitride film and the silicon oxide film are alternately laminated. | 2022-07-28 |
20220235268 | Soil stabilization material based on solid waste and bioenzyme, and preparation method thereof - A soil solidification material based on solid waste and bioenzyme, and a preparation method thereof are disclosed. The soil solidification material is composed of the following components in parts by weight: recycled aggregate 22-35 parts, steel slag 20-30 parts, high-calcium fly ash 16-24 parts, the bioenzyme 5-15 parts, an inorganic adsorbent 10-18 parts, an organic adsorbent 8-20 parts, industrial waste gypsum 25-35 parts, an activator 20-30 parts, sodium citrate 1-3 parts, and slaked lime 0.02-0.2 parts. The present disclosure adopts the recycled aggregate, the steel slag, the industrial waste gypsum and the high-calcium fly ash as the main components of the soil solidification material to reduce the cost. The soil solidification material of the present disclosure prepared by optimizing the proportion is capable of significantly improving the engineering properties of the soil or the mixed contaminated soil, and has significant economic and environmental benefits. | 2022-07-28 |
20220235269 | MECHANOTROPIC ELASTOMERS - Isotropic (amorphous) elastomers and methods of preparation are described. The isotropic elastomer may include a first monomer having an alkene functionality and a second monomer having a thiol functionality. The first monomer may be a liquid crystal monomer and the second monomer may be an isotropic monomer. Unlike polydomain LCEs, the isotropic elastomers may rapidly recover after deformation and have increased toughness relative to conventional elastomers prepared from wholly isotropic precursors. | 2022-07-28 |
20220235270 | DEFECT MEDIATED LYOTROPIC NEMATIC GEL - This invention relates to a gel comprising a colloid dispersed in a lyotropic nematic liquid crystal, the lyotropic nematic liquid crystal comprising defect lines formed by the colloid. The invention also relates to a method for making the gel comprising the steps of: (a) mixing a nematogen with a liquid and the colloid to form a resulting dispersion, and (b) applying shear to the resulting dispersion at a temperature such that a lyotropic nematic liquid crystal phase is formed. In addition, the invention relates to an adhesive, lubricant, ceramic, film, spray, gel, lotion, foam, nanowire, yarn, medical implant, wearable, bone graft material, 3D printing material, ink, agrochemical formulation, topical formulation, paint, coating, composite, energy storage material, advanced material, responsive composite, cosmetic product, personal care product, pharmaceutical or foodstuff comprising the gel. | 2022-07-28 |
20220235271 | HYBRID SILICONE COMPOSITE FOR HIGH TEMPERATURE APPLICATIONS - A hybrid silicone composite for high temperature insulation applications is disclosed. The hybrid silicone composite is formed of a mixture of liquid high consistency silicone rubber and solid high consistency silicone rubber and a thermally decomposable inorganic filler which are compounded together. The compounded material is then injection molded, over molded, compression molded, cast, laminated, extruded, calendered, adhered or dispensed. When the silicone composite is exposed to a high temperature, it forms an inorganic composite and maintains its insulating properties and dimensional stability. | 2022-07-28 |
20220235272 | POLYMERIZABLE SURFACTANTS HAVING WATER WHITENING RESISTANCE AND METHODS FOR USE - Disclosed are ethylenically unsaturated salts of allyl (poly)ether sulfates utilized as reactive surfactants or emulsifiers during emulsion polymerization. | 2022-07-28 |
20220235273 | ANTI-FREEZING DISPERSANT AND MANUFACTURING PROCESS THEREOF - The present disclosure provides methods of treating industrial processes with compositions, methods of manufacturing the compositions, and various anti-freezing compositions suitable for use in the industrial processes. The anti-freezing dispersant compositions may include, for example, sulfonated dispersants and winterization solvents. The anti-freezing dispersant compositions may prevent fouling in the industrial processes. | 2022-07-28 |
20220235274 | Oil in Water Wax Emulsion Composition - The present invention relates to compositions in the form of an oil-in-water emulsion preferably comprising an aqueous phase, a natural wax, at least two surfactants, and a neutralizing agent. | 2022-07-28 |
20220235275 | BLEND OF HYDROCARBON CONTAINING FOSSIL AND RENEWABLE COMPONENTS AND METHOD FOR PRODUCING SUCH BLEND - The invention relates to a hydrocarbon blend for input to a refinery and comprising a first blend component containing a renewable hydrocarbon component and a second blend component containing petroleum derived hydrocarbon to form at least part of a final hydrocarbon blend for processing in a refinery where the first blend component is characterized by comprising a hydrocarbon substance with at least 70% by weight having a boiling point above 220° C. and by having the characteristics (δ | 2022-07-28 |
20220235276 | ALKALI-ENHANCED HYDROTHERMAL PURIFICATION OF PLASTIC PYROLYSIS OILS - A method is disclosed for preparing fuel components from waste pyrolysis oil. Exemplary embodiments include providing a waste pyrolysis oil having plastic pyrolysis oil and/or tyre pyrolysis oil, and impurities; purifying the waste pyrolysis oil by hydrothermal treatment with water or alkaline water; separating the hydrothermally treated waste pyrolysis oil from an aqueous phase; preparing a hydroprocessing feed from the hydrothermally treated waste pyrolysis oil; hydroprocessing the hydroprocessing feed catalytically with hydrogen to cause hydrogenation; and recovering a hydrocarbon fraction boiling in a liquid fuel range. | 2022-07-28 |
20220235277 | Systems and Methods for Separating Hydrocarbons with Substantially Reduced Emissions - The invention generally relates to a modular crude oil refinery (MOOR). The MOOR is designed for smaller scale deployment with a capacity to process in the range of 3,000-4,000 barrels of crude oil per day in a single production unit and with the potential to scale to over 100,000 barrels per day with linked production units. More specifically, a MOOR includes a low temperature, low pressure primary separation reactor, condensing system and recirculation systems operating in a closed loop configuration that enable the production of both heavy and light hydrocarbon products with substantially no emissions. The MOOR has the capability to receive and process crude-oil feedstocks of varying API gravity and be controlled to produce a variety of both heavy and light products including cleaner-burning bunker fuels, jet fuels, diesel fuels, gasoline fuels and asphalt binders. | 2022-07-28 |
20220235278 | STEAM CRACKING PROCESS INTEGRATING OXIDIZED DISULFIDE OIL ADDITIVE - Oxidized disulfide oil (ODSO) compounds or ODSO compounds and disulfide oil (DSO) compounds are added to a steam cracker feed. During the thermal cracking, the ODSO or ODSO and DSO components in the steam cracker mixture minimize coke formation on the steam cracker coils. | 2022-07-28 |
20220235279 | Method of reducing octane loss in catalytic cracking of gasoline in S-zorb plant - The present invention discloses a method of reducing octane loss in catalytic cracking of gasoline in S-Zorb plant. The method comprises following steps: a. Collecting equipment data and adjusting differences thereamong to construct initial data sample set; b. Collating data sample set; c. Employing local linear s embedding to reduce dimension of independent variables, and trimming the independent variables to obtain reserved independent variables; d. Calculating correlation coefficients of the reserved independent variables and removing variables with too high correlation coefficients to obtain main variables; e. Constructing a BP neural network model of the main variables to obtain optimal octane loss prediction model; f. Employing the optimal octane loss prediction model to obtain a predicted optimal operating condition for each main variable. The present invention is different from traditional chemical mechanism method at aspect of building FCC technology process. For enterprises, they can employ it to analyze influencing factors of octane loss according to local conditions, and being able to reduce octane loss and improve quality of refined oil. | 2022-07-28 |
20220235280 | REACTIVE SILICA-ALUMINA MATRIX COMPONENT COMPOSITIONS FOR BOTTOMS CRACKING CATALYSTS - A bottoms cracking catalyst composition, comprising: about 30 to about 60 wt % alumina; greater than 0 to about 10 wt % of a dopant, measured as the oxide; about 2 to about 20 wt % reactive silica; about 3 to about 20 wt % of a component comprising peptizable boehmite, colloidal silica, aluminum chlorohydrol, or a combination of any two or more thereof; and about 10 to about 50 wt % of kaolin. | 2022-07-28 |
20220235281 | TURBULENT/FAST FLUIDIZED BED REACTOR WITH BAFFLES TO MAXIMIZE LIGHT OLEFIN YIELDS - Systems and methods for producing light olefins wherein a feed stream comprising naphtha is flowed into a reaction unit comprising a fast fluidized bed reactor coupled to and in fluid communication with a riser reactor. The fast fluidized bed reactor comprises baffles therein to minimize backmixing therein to maximize the production of light olefins. The effluent from the fast fluidized bed reactor is further flowed to the riser reactor. The lift gas, which can comprise nitrogen, methane, flue gas, or combinations thereof, is injected in the reaction united via a sparger. Effluent of the riser reactor is separated in a product separation unit to produce a product stream comprising light olefins and spent catalyst. Spent catalyst is further stripped by a stripping gas comprising methane, nitrogen, flue gas, or combinations thereof. Stripped spent catalyst is regenerated to produce regenerated catalyst, which is subsequently flowed to the fast fluidized bed reactor. | 2022-07-28 |
20220235282 | HEAT SOURCE FOR PYROLYSIS PROCESS - Systems and methods are provided for using a reverse flow reactor (or another reactor with flows in opposing directions at different parts of a process cycle) for pyrolysis of hydrocarbons. The systems and methods can include a reactor that includes a combustion catalyst to initiate and/or maintain combustion within the reactor in a controlled manner during the heating and/or regeneration portion(s) of the reaction cycle. A fuel can also be used that has a greater resistance to auto-combustion, such as a fuel that is composed primarily of methane and/or other hydrocarbons. During operation, the temperature in at least an initial portion of the reactor can be maintained at a temperature so that auto-ignition of the auto-combustion resistant fuel injected during the heating step(s) is reduced or minimized. This can allow combustion to be initiated when the auto-combustion resistant fuel comes into contact with the catalyst. Additionally, the amount and positioning of the catalyst within the reactor can be controlled so that combustion of the fuel takes place over a substantially longer period of time than combustion during a conventional reactor heating step. Because the fuel is moving within the reactor during combustion, extending the combustion time results in a substantial expansion of the volume where combustion occurs. Optionally in combination with an improved reaction cycle, this can expand the portion of the reactor that is directly heated by combustion, allowing for an improved temperature distribution within the reactor during the pyrolysis step. | 2022-07-28 |
20220235283 | PROCESSES AND SYSTEMS FOR PRODUCING UPGRADED PRODUCT FROM RESIDUE - Embodiments of the present disclosure are directed to a process for producing upgraded product from residue comprising atmospheric residue or vacuum residue upgrading comprising separating the residue through a Solvent Deasphalting (SDA) unit, wherein the SDA unit includes an asphaltene separator that separates the residue into asphaltene pitch and a stream comprising deasphalted oil (DAO) and resin, and a resin separator that subsequently separates the stream comprising DAO and resin into separate DAO and resin streams, treating the resin stream with supercritical water (SCW) to produce an upgraded resin stream, and hydroprocessing a portion of the upgraded resin stream and the DAO stream to produce the upgraded product. | 2022-07-28 |
20220235284 | DECREASING REFINERY FOULING AND CATALYST DEACTIVATION - Processes for preventing or minimizing the rate of upgrading catalyst deactivation in a petroleum refinery, preventing or minimizing the rate of silicone-containing deposits within refinery process equipment, or both utilizing high-field proton nuclear magnetic spectroscopy (NMR) to rapidly measure concentrations of polydimethylsiloxanes (PDMS) and its thermal degradation products in potential refinery feed stock and refinery intermediate streams with high sensitivity and precision. | 2022-07-28 |
20220235285 | Crude Oil Transportation - A method of improving the transportation of a crude oil which has been recovered from a crude oil well, the method comprising adding one or more glycerophospholipid(s) to a crude oil before and/or during the transportation of said crude oil. | 2022-07-28 |
20220235286 | Blends of low carbon and conventional fuels with improved performance characteristics - The present invention provides a blended fuel and methods for producing the blended fuel, wherein a low carbon fuel derived from a renewable resource such as biomass, is blended with a traditional, petroleum derived fuel. A blended fuel which includes greater than 10% by volume of low carbon fuel has an overall improved lifecycle greenhouse gas content of about 5% or more compared to the petroleum derived fuel. Also, blending of the low carbon fuel to the traditional, petroleum fuel improves various engine performance characteristics of the traditional fuel. | 2022-07-28 |
20220235287 | BIODIESEL FUEL MIXTURES - Provided herein are biodiesel fuel mixtures having improved properties for reducing NOx emissions as well as total particular matter emissions, CO emissions, and total hydrocarbon emissions. | 2022-07-28 |
20220235288 | STEAM CRACKING CONTROL FOR IMPROVING THE PCI OF BLACK GRANULES - The present disclosure relates to a method for continuously preparing a pulverulent material having a calorific power greater than the calorific power of the initial biomass, the method comprising a steam cracking step, wherein the initial biomass consists of elements having a grain size distribution of between P25 and P100, having a humidity of less than 27%, and directly subjected to a steam cracking treatment. | 2022-07-28 |
20220235289 | RECIRCULATING HIGH PRESSURE LIPID (HPL) EXTRACTOR, INFUSER AND BONDER, AND SYSTEM AND METHOD OF USE THEREOF - A recirculating high pressure lipid extractor includes a kettle with a sealed interior configured for pressurizing and heating a fluid mixture. A flow funnel is positioned in a lower portion. A removable material basket is positioned on top of the flow funnel in an upper section. The removable material basket is configured to hold a material inside the removable material basket. A drain and inlet port is at a bottom of the kettle in communication with the sealed interior of the kettle. A recirculation port is approximate a top of the kettle in communication with the sealed interior of the kettle. Wherein, when the fluid mixture is inserted into the kettle, the recirculating high pressure lipid extractor is configured to pressurize and heat the fluid mixture and recirculate the pressurized and heated fluid mixture from the recirculation port into the drain and inlet port. | 2022-07-28 |
20220235290 | Cyclohexene Propanal Derivatives as Perfuming Ingredients - Described herein is a compound of formula (I) | 2022-07-28 |
20220235291 | EXTRACTING AND REFINING PLANT CUTICULAR WAXES FROM AQUEOUS DISPERSION USING A CAPTURING AGENT - The present invention concerns a method of extracting and refining wax from plant material. Briefly, the method comprises the steps of (a) providing plant by material comprising cuticular wax, (b) disassociating cuticular wax from the plant material, thereby obtaining a sample comprising plant derived cuticular wax and dewaxed plant material in an aqueous suspension, (c) solubilizing the plant derived cuticular wax by increasing the temperature of the sample, (d) separating the suspension into a solid fraction and a liquid fraction comprising melted plant derived cuticular wax, (e) mixing the liquid fraction with a capturing agent, wherein the capturing agent has a boiling point above 85° C. at ambient pressure, (f) separating the mixture into an aqueous fraction and a capture fraction comprising capturing agent and plant derived cuticular wax, (g) recovering the plant derived cuticular wax from the capture fraction. | 2022-07-28 |
20220235292 | SYSTEMS AND METHODS FOR STABILIZING EMULSIONS - Provided herein are methods and compositions related to forming cross-links between surfactant molecules at an interface between dispersed phase partitions and a continuous phase in an emulsion, and uses of such cross-linked emulsions. | 2022-07-28 |
20220235293 | AUTOMATIC DISHWASHING METHOD WITH AMPHIPHILIC GRAFT POLYMER IN THE RINSE - A method of cleaning dishware in a domestic dishwasher using a program having a cleaning cycle and a rinse cycle, the method includes the steps of placing the dishware in the dishwasher; delivering a cleaning composition into the cleaning cycle to form a wash liquor and subjecting the dishware to the wash liquor; and delivering a rinse composition to form a rinse liquor, the composition includes an amphiphilic graft polymer based on water-soluble polyalkylene oxides as a graft base and side chains formed by polymerization of a vinyl ester component, wherein said amphiphilic graft polymer is water-soluble or water-dispersible and has a weight average molar mass (Mw) of from about 3,000 to about 100,000 and subjecting the dishware to the rinse liquor. | 2022-07-28 |
20220235294 | FABRIC CARE COMPOSITIONS THAT INCLUDE A GRAFT COPOLYMER AND RELATED METHODS - Fabric care compositions that include a graft copolymer, which may include (a) a polyalkylene oxide, such as polyethylene oxide (PEG); (b) N-vinylpyrrolidone (VP); and (c) a vinyl ester, such as vinyl acetate. Methods and uses relating to such compositions and/or graft copolymers. | 2022-07-28 |
20220235295 | SOLID ENZYMATIC DETERGENT COMPOSITIONS AND METHODS OF USE AND MANUFACTURE - The present disclosure relates to a solid, enzymatic detergent compositions and methods of making and using the same. In a preferred embodiment, the detergent compositions are particularly useful for cleaning medical and dental instruments. In a preferred embodiment the compositions are particularly use for cleaning ware. | 2022-07-28 |
20220235296 | ORGANIC COMPOUNDS - The present invention relates to compounds of formula (I) as herein defined, capable of releasing fragrant compounds in a controlled manner into the surroundings. The present invention is also concerned with a process for their production, and consumer products comprising them. | 2022-07-28 |
20220235297 | SOLUBLE LAUNDRY SHEET COMPRISING POLYOL OR METAL ION CHLORIDE - The present invention provides a water-soluble laundry sheet comprising a detergent ingredient for laundry, a water-soluble film-forming polymer, and an alkali binder, wherein the laundry sheet comprises any one or more selected from the group consisting of polyols and metal ion chlorides. The present invention provides a water-soluble laundry sheet with enhanced formulation stability, storage stability, and sheet solubility. | 2022-07-28 |
20220235298 | HOP ACIDS FORMULATIONS AND METHODS - The present disclosure provides compositions and methods for improved hop acids formulations comprising myristic acid which have improved stability characteristics. The formulations may be used as an anti-bacterial agent in fermentation processes. | 2022-07-28 |
20220235299 | BEER-TASTE FERMENTED MALT BEVERAGE - An object of the invention is to provide a beer-taste fermented malt beverage with an alcohol concentration of less than 1% (v/v), which is excellent in robust feeling of drinking, excellent in sweetness in harmony with sourness, and has beer-like flavor. The means for solving the problems is a beer-taste fermented malt beverage containing a wort fermented liquid, having a genuine extract component of 3.5% (w/w) or more, and an alcohol concentration of less than 1% (v/v). | 2022-07-28 |
20220235300 | DISTILLED SPIRIT - An object of the present invention is to obtain a distilled liquor which has a sufficient excellent citrus aroma but has reduced unfavorable odor generated by distillation. A distilled liquor with an excellent citrus aroma is produced by subjecting an aqueous ethanol solution having a citrus fruit immersed therein to distillation under atmospheric pressure while the ethanol concentration of a distillate falls within the range of from 50 to 80%. | 2022-07-28 |
20220235301 | COCKTAIL SMOKING CHIMNEYS AND METHODS FOR INFUSING SMOKE INTO COCKTAILS, BEVERAGES AND ALCOHOLIC DRINKS - A cocktail smoking chimney for infusing smoke into a beverage includes a sealing base having a center and an outer perimeter. A chimney stack is aligned with the center of the sealing base and projects from a top major surface of the sealing base. A combustion chamber is disposed within the chimney stack. A smoke directing lip is aligned with the center of the sealing base and projects from a bottom major surface of the sealing base. The combustion chamber is aligned with the smoke directing lip. One or more smoke transfer openings are formed in the sealing base, each having an upper end in fluid communication with the combustion chamber and a lower end that is surrounded by the smoke directing lip. The sealing base, the chimney stack, and the smoke directing lip are made of wood. A combustible material may be packed into the combustion chamber. | 2022-07-28 |
20220235302 | COMPOSITION AND METHOD FOR MAKING DISTILLED SPIRIT - A method for making a distilled spirit includes distilling a liquor comprising alcohol to form a distilled liquor; and contacting the distilled liquor with peat. The peat may include peat dry matter. The peat may include dried peat. The peat may include partially charred peat. The peat may include 50 wt-% or less of inorganic carbon on a dry weight basis. The peat may be arranged in a filter cartridge. The distilled liquor may be contacted with the peat for at least 5 seconds. A composition includes distilled liquor comprising alcohol and water; and peat. The peat may include peat dry matter. The peat may include dried peat. The peat may include partially charred peat. The peat may include 50 wt-% or less of inorganic carbon on a dry weight basis. The composition may include 40 vol-% or more of alcohol based on liquid components of the composition. | 2022-07-28 |
20220235303 | Multi-Well Plate and Method for Preparing Same - The invention relates to a multi-well plate comprising a support, the upper surface of which is at least partially covered with a continuous layer of a hydrogel in contact with the lower surface of a bottomless multi-well plate, the support, the continuous layer, and the bottomless multi-well plate being adhered by means of an adhesive which extends from at least certain portions of the lower surface of the bottomless multi-well plate up to certain portions of the upper surface of the support by passing through the continuous layer of hydrogel, each well of the bottomless multi-well plate being entirely surrounded by the at least certain portions of the lower surface. The application also relates to a method for preparing the multi-well plate and the use thereof for in vitro cell culture. | 2022-07-28 |
20220235304 | BIOPROCESSING SYSTEM AND TUBING AND COMPONENT MANAGEMENT APPARATUS FOR A BIOPROCESSING SYSTEM - A bioreactor vessel includes a bottom, a peripheral sidewall, the bottom and the peripheral sidewall defining an interior space for receiving a flexible bioprocessing bag, a recess in the bottom for receiving a base plate of the flexible bioprocessing bag, and a locking mechanism configured to retain the base plate in the recess. | 2022-07-28 |
20220235305 | SYSTEMS AND METHODS FOR CELL CULTURING - Cell culture systems and methods provide improved immunotherapeutic product manufacturing with greater scalability, flexibility, and automation. Cell culture systems are configured with interchangeable cartridges, allowing versatility and scalability. Systems are configured to have multiple connected cell culture chambers, which allows parallel processing of different types of cells. Gas-impermeable cell culture chambers and methods for generating cells in closed systems prevent contamination and user error. Methods for recycling cell culture medium provide additional efficiencies. | 2022-07-28 |
20220235306 | Surface Modified Separation Media - A substrate surface may be modified with a polymer coating to render the surface suitable for plasma functionalization. The polymer coating is deposited onto the surface at ambient temperature to a thickness of less than 0.1 μm. The polymer coating includes poly(p-xylylene) or a derivative thereof, and is capable of penetrating into pores of a porous substrate while no substantially altering the porosity of the substrate. The coated substrate is selected from a material lacking a primary or secondary aliphatic hydrogen atom. | 2022-07-28 |
20220235307 | SCAFFOLD MATERIAL FOR CELL CULTURE AND CELL CULTURE CONTAINER - Provided is a cell culture scaffold capable of allowing cell masses to be formed easily and efficiently. A cell culture scaffold according to the present invention includes a substrate; and a protrusion formed by patterning in a pattern of a dot or a line on the substrate, wherein the protrusion contains a synthetic resin, the synthetic resin contains at least a polyvinyl alcohol derivative or a poly(meth)acrylic resin, the protrusion has cell adhesion, and a portion of the protrusion located at the protrusion center position in plan view has an average height of 10 nm or more and 10 μm or less. | 2022-07-28 |
20220235308 | CELL GROWTH MATRIX - The invention provides a structured cell growth matrix or assembly comprising a one or more spacer layers and one or more cell immobilization layers. The invention further provides a bioreactor comprising said matrix or assembly. | 2022-07-28 |
20220235309 | BIOREACTOR CHAMBER AND SYSTEMS THEREOF - Described herein are bioreactor chambers and systems thereof. In an embodiment, a single-plate symmetrical bioreactor chamber is described, comprising: a flow channel extending along a first axis, wherein the flow channel comprises an inlet and an outlet at opposing ends of 5 the flow channel; a pair of struts on opposing ends of a second axis, wherein the second axis is substantially perpendicular to the first axis, wherein each strut of the pair of struts are placed on opposing sides of the flow channel, wherein the struts are configured to be coupled to a bidirectional linear actuator and configured to provide a strain perpendicular to a fluid flow through the flow channel, wherein the strain does not laterally displace cells present in the flow channel. | 2022-07-28 |
20220235310 | ASEPTIC CELL PROCESSING AND PRODUCTION WITH NO CHEMICAL BIOCIDES - A method and apparatus of aseptic processing and production of cells in a non-sterile enclosure apparatus without chemical biocides is disclosed, by controlling the level of humidity throughout the enclosure to 25% relative humidity (RH) or less, and preferably 20% or 15% or less RH. In addition, the temperature is controlled to 37° C., and consistent gas flow is maintained the enclosure. Colony forming units from microbial contamination detected by environmental monitoring within the enclosure are significantly reduced in this method. | 2022-07-28 |
20220235311 | AUTOMATED BIOMANUFACTURING SYSTEMS, FACILITIES, AND PROCESSES - Disclosed are a process and an automated facility for manufacturing a purified protein of interest. The protein of interest can be a recombinant or naturally occurring protein and/or a therapeutic or other medically useful protein. For example, the disclosed process and automated facility are useful for manufacturing a purified protein drug substance. | 2022-07-28 |
20220235312 | AUTOMATED BIOMANUFACTURING SYSTEMS, FACILITIES, AND PROCESSES - Disclosed are a process and an automated facility for manufacturing a purified protein of interest. The protein of interest can be a recombinant or naturally occurring protein and/or a therapeutic or other medically useful protein. For example, the disclosed process and automated facility are useful for manufacturing a purified protein drug substance. | 2022-07-28 |
20220235313 | MYCOPLASMA MEDIA FORMULATIONS - The present invention relates to media formulations free of swine serum and animal (primarily bovine brain and spinal cord) origin ingredients for | 2022-07-28 |
20220235314 | RECOMBINANT ESCHERICHIA COLI STRAIN FOR PRODUCING SUCCINIC ACID AND CONSTRUCTION METHOD THEREOF - The invention provides a recombinant | 2022-07-28 |
20220235315 | TARGETING SEQUENCES FOR PAENIBACILLUS-BASED ENDOSPORE DISPLAY PLATFORM - Signal sequences useful for targeting proteins and peptides to the surface of endospores produced by | 2022-07-28 |
20220235316 | Novel Hydrogels - Hydrogels are based on the reaction of thiols with electron-deficient heteroaromatics. This reaction can take place under physiological conditions and is thus suitable for the encapsulation of cells. | 2022-07-28 |
20220235317 | COMPOSITION FOR INHIBITING EXTENSION OF POPULATION DOUBLING TIME OF STEM CELLS, COMPRISING C-MET AGONIST ANTIBODY AS ACTIVE INGREDIENT - The present disclosure relates to a composition for inhibiting the extension of a population doubling time of stem cells, comprising a c-Met agonist antibody as an active ingredient, and more particularly, to a medium additive for inhibiting the extension of a population doubling time of stem cells, comprising a c-Met agonist antibody as an active ingredient, a medium composition for culturing stem cells, comprising the medium additive, and a method for inhibiting the extension of a population doubling time. | 2022-07-28 |
20220235318 | TAURINE SUPPLEMENTED CELL CULTURE MEDIUM AND METHODS OF USE - The specification describes a composition comprising an improved eukaryotic cell culture medium, which can be used for the production of a protein of interest. Taurine can be added to the serum-free media or chemically-defined media to increase the production of a protein of interest. Methods for recombinantly expressing high levels of protein using the media compositions are included. | 2022-07-28 |
20220235319 | METHOD OF USING NANO-SIZED MATERIALS FOR ENHANCING PRODUCTION OF SECONDARY METABOLITES IN PLANTS - One aspect of the disclosure is directed to a method for activation/enhancement of cell growth of a plant. The method also stimulates the production of pharmaceutically active metabolites, including alkaloids, in plant cell cultures. The method includes providing a nano-sized material contained agent, and treating the plant with the nano-sized material contained agent to allow sufficient interaction of cells of the plant with the nano-sized material so as to activate/enhance the cell growth of the plant or to stimulate the production of pharmaceutically active metabolites. | 2022-07-28 |
20220235320 | DISSOLVABLE MICROCARRIERS FOR CULTURING CELLS AND RELATED METHODS - A cell culture article is provided. The cell culture article includes a substrate of a polygalacturonic acid compound crosslinked with a divalent cation, the polygalacturonic acid compound being selected from at least one of: pectic acid; partially esterified pectic acid, partially amidated pectic acid and salts thereof. The substrate is digestible by digestion reagents into components including of galacturonic acid monomers and the divalent cation. Methods of harvesting cells from the cell culture article are also provided. The methods include performing a series of wash and/or centrifugation cycles to reduce components in the harvest solution. | 2022-07-28 |
20220235321 | METHOD OF GENERATING HEPATIC CELLS - The invention relates to methods of generating hepatic cells by overexpressing combinations of transcription factors, in particular for use in cellular reprogramming methods. | 2022-07-28 |
20220235322 | REPRODUCIBLE BRAIN ORGANOIDS AND METHODS OF MAKING - The present disclosure is directed to methods of producing dorsal forebrain organoids having cores with a very low incident of apoptotic and hypoxic cells and having highly similar cell types and cell type prevalence. The present disclosure is also directed to compositions comprising such organoids and the use of such organoids for the screening of agents. | 2022-07-28 |
20220235323 | Use of a Warmer For Promoting a Biological Reaction - The present invention relates to the use of warmers, or autonomous heat packs, for heating and maintaining a solution at a suitable temperature, for the period of time required to accomplish a chemical, biochemical or biological reaction, in particular in molecular biology or cell biology applications. Biology kits containing warmers are also part of this invention. | 2022-07-28 |
20220235324 | MULTIPLE ANTIGEN SPECIFIC CELL THERAPY METHODS - The present invention provides methods of preparing a population of activated T cells by co-culturing T cells with dendritic cells loaded with a plurality of tumor antigen peptides. Also provided are methods of treating cancer in an individual using the activated T cells, pharmaceutical compositions and kits for cell-based cancer immunotherapy. | 2022-07-28 |
20220235325 | STIMULATION OF DENDRITIC CELL ACTIVITY BY HOMOTAURINE AND ANALOGUES THEREOF - Disclosed are means, methods, and compositions of matter useful for enhancement of dendritic cell activity. In one embodiment the invention provides the use of GABA agonists such as homotaurine for stimulation of dendritic cell activity. In one embodiment said dendritic cell activity is enhancement of natural killer cell activity and/or of T cell activity. In one embodiment NK cell activity is ability to induce cytotoxicity in neoplastically transformed cells, whereas T cell activity is either cytokine production for CD4 cells or cytotoxicity for CD8 cells. | 2022-07-28 |
20220235326 | ENHANCEMENT OF FIBROBLAST THERAPEUTIC ACTIVITY BY RNA - Embodiments of the disclosure encompass methods and compositions related to the ability of RNA to enhance therapeutic activity of fibroblasts. In some embodiments, administration of double stranded RNA is performed through providing polyinosinicpolycytidylic acid (poly (I:C)) or a derivative thereof at a concentration sufficient to induce therapeutic properties and/or to augment therapeutic properties onto said fibroblasts. In one embodiment, enhanced therapeutic activity comprises augmentation of fibroblast migratory activity; efficacy for angiogenesis; efficacy for immune modulation; differentiation ability; production of one or more trophic factors; and/or the ability to resist apoptosis. | 2022-07-28 |
20220235327 | PANCREATIC DIFFERENTIATION - In some aspects, disclosed herein are methods and compositions for generating enterochromaffin cells. In some aspects, the methods and compositions disclosed herein relate to use of an inhibitor of IL-4/JAK3 signaling pathway. In other aspects, disclosed herein are cell compositions, pharmaceutical compositions, and medical devices that relate to pancreatic cells that are generated according to the methods disclosed herein. | 2022-07-28 |
20220235328 | HUMAN DISEASED AND NORMAL KIDNEY EPITHELIAL CELL CULTURES AND USES THEREOF - Provided herein are compositions and methods for producing immortalized, cystogenic, single cyst-derived cells from a polycystic kidney. Populations of immortalized, cystogenic, single cyst-derived cells from a polycystic kidney are also provided. | 2022-07-28 |
20220235329 | METHODS FOR GENERATING INDUCED PLURIPOTENT STEM CELLS VIA CELL CYCLE SYNCHRONIZATION - The techniques described herein provide for improved efficiency of iPSC production from biological cells. The approach achieves improved iPSC production efficiency by obtaining a set of cells whose cell cycles are synchronized at a specific, desired cell cycle phase, such as mitotic phase (also referred to as M phase). The efficacy with which such synchronized cells can be transformed into iPSCs is higher than for an arbitrary set of cells that comprises cells at a variety of different stages in their cycles. Accordingly, the approaches described herein allow efficient generation of iPSCs, thereby facilitating myriad technologies for personalized and regenerative medicine that rely upon the effective production of iPSCs. | 2022-07-28 |
20220235330 | METHODS FOR CREATING INTEGRATION-FREE, VIRUS-FREE, EXOGENOUS ONCOGENE-FREE IPS CELLS AND COMPOSITIONS FOR USE IN SUCH METHODS - Methods are disclosed for reprogramming a somatic cell, including an adherent cell and a cell in suspension, into an induced pluripotent stem comprising expressing exogenous Sox-2, exogenous Klf-4, exogenous Oct3/4 from DNA that has not integrated into the genome of the somatic cell, suppressing p53 activity within the somatic cell, and exposing the somatic cell to reprogramming-assistance factors comprising an exogenous Alk-5 inhibitor, an exogenous histone deacetylase inhibitor, and an exogenous activator of glycolysis. Compositions and kits for use in such methods are also disclosed as are cells made by such a method. | 2022-07-28 |
20220235331 | PRODUCTION METHOD AND KIT OF INDUCED PLURIPOTENT STEM CELLS - A method of producing induced pluripotent stem cells including a step for introducing an initialization factor into somatic cells of a mammal, and culturing in a neural stem cell culture medium to obtain induced neural stem cell-like cells, and a step for cultivating said induced neural stem cell-like cells in a growth medium to obtain induced pluripotent stem cells, wherein the initialization factor contains an OCT family, a SOX family, a KLF family, a MYC family, a LIN28 family and a P53 function inhibitor. | 2022-07-28 |
20220235332 | Fast and Accurate Three-Plasmid Oncolytic Adenovirus Recombinant Packaging System AD5MIXPLUS and Application Thereof - A fast and accurate three-plasmid oncolytic adenovirus recombinant packaging system Ad5MixPlus and an application thereof are provided. The system is composed of three adenovirus recombinant plasmids. The core technology of the system is that two sets of different site recombination sequences are skillfully loaded on a first 5-type adenovirus right arm backbone plasmid large vector, then two small shuttle plasmids respectively provide a right arm-modified Hexon/E3/Fiber sequence and an E1a expression cassette controlled by a left arm tumor-specific promoter, and the difficulties and obstacles to the modification of the adenovirus backbone large vector are overcome. After two rounds of site-specific recombination, the ideal oncolytic adenovirus is packaged accurately and quickly. | 2022-07-28 |
20220235333 | Modified Phenylalanine Dehydrogenase - The present invention provides a unit and a method useful for more precise phenylalanine measurement. More specifically, the present invention provides a modified phenylalanine dehydrogenase that includes a mutation of at least one amino acid residue so as to improve the characteristics (for example, substrate specificity, solubility, and phenylalanine dehydrogenase activity) of a phenylalanine dehydrogenase related to measurement of phenylalanine, a method for analyzing phenylalanine by measuring phenylalanine contained in a test sample using the modified phenylalanine dehydrogenase, and others. | 2022-07-28 |
20220235334 | TOPICAL COMPOSITIONS COMPRISING DIAMINOOXIDASE FOR THE TREATMENT OR PREVENTION OF DISEASES ASSOCIATED WITH HIGH HISTAMINE LEVELS WHICH INVOLVE AN INCREASE IN PAIN - The present invention relates to a pharmaceutical, cosmetic or dermo-cosmetic composition that comprises DAO, for use in the prevention or treatment of diseases or pathological conditions associated with high levels of histamine in blood which involve an increase in pain, preferably fibromyalgia, characterised in that the application of the composition is topical. | 2022-07-28 |
20220235335 | Glycosyltransferase Mutant and Use Therefor - Provided are a mutant glycosyltransferase UGT76G1 and a use therefor, the catalytic activity, the substrate selectivity, and/or the substrate specificity of the mutant glycosyltransferase UGT76G1 having been changed. Mutation at specific points can promote the catalytic activity for 1,3-glycosylation of a substrate containing 1,2-diglucosyl (sophorosyl), and weaken the catalytic activity thereof to perform 1,3-glycosylation on a glucose monosaccharide substrate base. Also provided are mutations that weaken the catalytic activity of glycosyltransferase UGT76G1, able to increase accumulation of a specific stevioside intermediate. | 2022-07-28 |
20220235336 | ENGINEERED POLYMERASES FOR IMPROVED SEQUENCING - Provided are nucleic acids encoding engineered polymerases comprising at least one modification in a motif A and/or at least one modification in a motif B of the polymerase and engineered polymerases encoded by the nucleic acids. Also provided are engineered DNA polymerases comprising a variant of SEQ ID NO:1, SEQ ID NO:2, or SEQ ID NO:3, the variant being at least 80% identical to SEQ ID NO:1, SEQ ID NO:2 or SEQ ID NO:3 and comprising an amino acid substitution at one or more positions selected from the group consisting of L408, Y409, P410, R484, A/L485, and I486. Methods, vectors, kits, and compositions comprising the nucleic acids and compositions, methods and kits comprising the engineered polymerases are also provided. | 2022-07-28 |
20220235337 | PHI29 DNA POLYMERASE MUTANTS WITH IMPROVED PRIMER RECOGNITION - Disclosed herein are mutants of bacteriophage Phi29 DNA polymerase with improved primer recognition, compared to the wild-type enzyme. Certain mutants comprise one or both of the mutations K64R or M97K. The provided mutants are capable of using more efficiently shorter and longer random synthetic DNA primers than wild-type Phi29 DNA polymerase, generating more amplification product in Multiple Displacement Amplification (MDA) reactions. The inventive mutants amplify human genomic DNA with less bias and better coverage in comparison to reactions carried out with wild-type Phi29 DNA polymerase. | 2022-07-28 |
20220235338 | ENGINEERED POLYMERASES FOR IMPROVED SEQUENCING BY BINDING - Provided herein are engineered DNA polymerases comprising modifications improving accuracy and processivity of the polymerase including modifications in the Motif A region, optionally, along with additional modifications in the palm and/or exonuclease domains of the polymerase. Also provided are nucleic acids encoding the engineered DNA polymerases comprising modifications in motif A of the polymerase, optionally, with additional modifications. Methods, vectors, kits, and compositions comprising the nucleic acids and compositions, methods and kits comprising the engineered polymerases are also provided. | 2022-07-28 |
20220235339 | FCE mRNA Capping Enzyme Compositions, Methods and Kits - The present disclosure relates to compositions, kits, and methods of making RNA vaccines having an appropriate cap structure. Systems, apparatus, compositions, and/or methods may include and/or use, in some embodiments, non-naturally occurring single-chain RNA capping enzymes. In some embodiments, an RNA capping enzyme may include an FCE variant having (a) an amino acid sequence at least 90% identical to positions 1 to 878 of SEQ ID NO: 1, and/or (b) one or more substitutions relative to SEQ ID NO: 1 at a position selected from positions corresponding to positions 215, 337, 572, 648, and 833 (e.g., a position selected from positions corresponding to position 215, 337, and 572) of SEQ ID NO: 1. | 2022-07-28 |
20220235340 | NOVEL CRISPR-CAS SYSTEMS AND USES THEREOF - The disclosure provides for systems, methods, and compositions for targeting polynucleotides. More particularly, the disclosure provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA and wherein the CRISPR effector protein is a Cas protein. | 2022-07-28 |
20220235341 | ALPHA-AMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME - The present invention relates to alpha-amylase variants of a parent alpha-amylase wherein said alpha-amylase variants have an improved wash performance as compared to said parent alpha-amylase. The invention also relates to compositions comprising the variants of the invention, uses of said variants and methods of producing said variants. | 2022-07-28 |
20220235342 | METHOD - The present invention relates to a method for identifying a pepsin resistant alpha amylase enzyme for use in a feed supplement comprising: i) providing an alpha amylase enzyme; ii) admixing said alpha amylase with corn based feed and buffer o solution comprising a pepsin concentration of 9000 U/ml at pH 3, 40° C., 500 rpm for at least 120 minutes and analysing alpha amylase activity on said alpha amylase compared to a control sample; wherein said control sample differs in that no pepsin is o present during incubation; and iii) selecting an alpha amylase enzyme which substantially maintains alpha amylase activity under the assay conditions; feed supplements and feedstuffs comprising a pepsin resistant alpha amylase and the use of pepsin resistant alpha amylases in feed. | 2022-07-28 |
20220235343 | NOVEL ADP-RIBOSYL CYCLASE AND INHIBITOR THEREOF - The present disclosure relates to a pharmaceutical composition containing an inhibitor against the expression or activation of a novel ADP-ribosyl cyclase or a naturally occurring variant thereof as an active ingredient for preventing or treating an ADP-ribosyl cyclase-mediated disease. In addition, the present disclosure relates to a composition for diagnosis of an ADP-ribosyl cyclase-mediated disease, the composition containing an agent for measuring a gene expression level or protein level of the ADP-ribosyl cyclase or a naturally occurring variant thereof. The composition of the present disclosure has the effect of inhibiting calcium increase in kidney cells, which is attributed to angiotensin II-induced ADP-ribosyl cyclase expression or activation, and as such can be advantageously used as a therapeutic agent for an ADP-ribosyl cyclase-mediated disease, particularly a renal disease. | 2022-07-28 |
20220235344 | TRYPSIN VARIANTS WITH IMPROVED ENZYMATIC PROPERTIES - The present invention relates to trypsin variants with improved enzymatic properties, and particularly relates to a mutated trypsin comprising an amino acid substitution at least at two amino acid positions leading to an increased affinity for the nucleophilic substrate and/or at least at two amino acid positions leading to a reduced hydrolysis activity. | 2022-07-28 |
20220235345 | METHODS FOR PREPARATION OF ACTIVE SEPARASE - Provided herein are polypeptide constructs containing a securin, e.g., a full-length securin or a truncated securin, fused to a separase. The polypeptide constructs may further contain linker peptides, protease recognition sites, and unfoldase recognition sites to facilitate expression and/or purification. Methods for obtaining the polypeptide constructs with active separase activity are also described, as well as methods for identify separase modulator compounds such as separase inhibitors. | 2022-07-28 |
20220235346 | MODIFIED CASPASE-9 POLYPEPTIDES AND METHODS OF USE THEREOF - Provided herein are modified caspase-9 polypeptides, and chimeric caspase-9 proteins containing the modified caspase-9 polypeptides. The disclosure further provides polynucleotides encoding these proteins, engineered host cells containing these polynucleotides and proteins, including host cells that co-express a chimeric antigen receptor, and methods of making and using the same. | 2022-07-28 |
20220235347 | COMPOSITIONS AND METHODS FOR TREATING HEMOGLOBINOPATHIES - The present invention features compositions and methods for editing deleterious mutations associated with hemoglobinopathies, such as sickle cell disease (SCD). In particular embodiments, the invention provides methods for correcting mutations in a beta globin polynucleotide using modified adenosine base editors termed “ABE8” having unprecedented levels (e.g., >60-70%) of efficiency. | 2022-07-28 |
20220235348 | CRISPR METHODS FOR TREATING CANCERS - Methods for reversing one or more mutations in the telomerase (TERT) promoter are provided and may be used to treat a cancer. In some embodiments, programmable base editing (PBE) is used to correct a mutated TERT promoter (e.g., −124 C>T, −228C>T, or −250C>T to −124 C, −228C, or −250C, respectively) by using a single guide (sg) RNA-guided and deactivated | 2022-07-28 |
20220235349 | ANTI-CD137 ANTIBODIES AND METHODS OF USE THEREOF - The instant disclosure provides antibodies that specifically bind to CD137 (e.g., human CD137) and increases CD137 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies. | 2022-07-28 |
20220235350 | SYSTEM AND METHOD FOR PREPARING MRNA - The present application belongs to the technical field of mRNA preparation, and discloses a system and a method for preparing mRNA, which can shorten a preparation period, and avoid degradation of an mRNA product due to the introduction of RNase by manual pipetting. The system for preparing mRNA comprises a PCR amplification device configured to amplify DNA; a plurality of raw reagent tubes, each of which is configured to provide a single reagent; and a reaction device configured to allow reagents to react. Specifically, the reaction device comprises a test tube rack configured to support reaction tubes, a semiconductor chilling plate connected to the test tube rack, a fin type radiator disposed under the test tube rack, and a cooling fan disposed under the fin type radiator; wherein the raw reagent tubes are connected to the reaction tubes via a solenoid valve module and a peristaltic pump module, and the solenoid valve module and the peristaltic pump module are connected with a control device and are controlled by an upper computer control program. | 2022-07-28 |
20220235351 | PROTEASE-RESISTANT SYSTEMS FOR POLYPEPTIDE DISPLAY AND METHODS OF MAKING AND USING THEREOF - The present invention generally relates to bacterial polypeptide display systems, libraries using these bacterial display systems, and methods of making and using these systems, including methods for improved display of polypeptides on the extracellular surface of bacteria using circularly permuted transmembrane bacterial polypeptides that have been modified to increase resistance to protease degradation and to enhance polypeptide display characteristics. | 2022-07-28 |
20220235352 | METHOD AND SYSTEM FOR IDENTIFICATION OF TARGET SITES IN PROTEIN CODING REGIONS FOR COMBATING PATHOGENS - A method and system for identification of target sites in protein coding regions for combating pathogens has been provided. The method relates to identifying a set of nucleotide repeat sequences that occur within the complete coding region of a specific protein that is involved in the pathogenicity of the infectious bacteria and which occurs in multiple copies on the pathogen genome and utilizing various laboratory acceptable methods to debilitate the identified target sequence on the pathogen genome, as well as use of enzymatic machinery to target and cleave its flanking genes on the genome. The set of nucleotide repeat sequences forming a part of or the complete coding region of a specific protein on the pathogen genome may be flanked by genes on either side that can be targeted as well. The present disclosure further includes administration of a cocktail comprising antimicrobial drugs, biofilm inhibitors and the novel construct. | 2022-07-28 |
20220235353 | PROTECTIVE ELEMENTS FOR NUCLEIC ACID SYNTHETIC BIOLOGY - Nucleic acids (DNA and RNA) provide a versatile platform for engineering synthetic biology in a variety of technology areas including medicine, science, agriculture, and energy. In many settings, degradation of nucleic acid molecules poses a significant engineering challenge as the molecules do not function if they have been degraded. In some embodiments, nucleic acid protective elements (PELs) are used to protect chemically synthesized or expressed nucleic acid molecules from degradation. PELs may be derived from all or part of a viral xrRNA sequence and/or structural motif, PELs may include rationally designed sequences and/or structural motifs, PELs may be engineered using directed evolution, and in some embodiments, PELs comprise a mixture of biologically derived, rationally designed sequence and/or structural motifs, and/or sequences and/or structural motifs that are engineered by directed evolution. In some embodiments, PELs significantly enhance the performance of nucleic acid synthetic biology, protecting nucleic acid regulatory and/or structural elements from degradation to increase regulatory dynamic range, fractional dynamic range, fold-change, and/or other performance metrics. In some embodiments, PELs that reduce nucleic acid degradation provide a platform technology for enhancing the performance of synthetic biology, with applications including therapeutics, diagnostics, biological research tools, vaccines, crop protection, molecular manufacturing, sustainable energy production, and other areas involving nucleic acids. | 2022-07-28 |