31st week of 2019 patent applcation highlights part 30 |
Patent application number | Title | Published |
20190233752 | System and Process for Producing Biomass Pellets - A system for producing biomass pellets comprising a pan mill for comminuting a biomass material, a treatment means in which the comminuted biomass material is treated with an oxidizing reactant and a pellet press for pressing pellets from the treated biomass material. The invention further relates to an associated process. The intention is to initiate during pellet production oxidation reactions which can otherwise result in autoignition of the pellets in pellet heaps. | 2019-08-01 |
20190233753 | PRETREATMENT OF FIBEROUS BIOMASS - A conventional agricultural “cuber” machine was modified to transform fibrous, low density cellulosic biomass into a mechanically stable form suitable for use as a feed stock to a bulk flow torrefier process without requiring the addition of a “binder” or other such adjuvant. Certain disclosed embodiments of the product concern a compact “cube” or “thin puck” of raw cellulosic biomass having a density of from 4 to 15 times the bulk density of the shredded raw biomass or from 20 to 32 lb/cu ft. The moisture content is below 10%, typically 3-8%. The strength of the product as measured by dropping the product onto a hard surface from a height of 3 ft. will not produce more than 10% breakage. The products of the present invention can be produced having any desirable dimensions, such as substantially square-, rectangular- or parallelogram-shaped product having at least one dimension of from about 5 to about 30 millimeters, which corresponds to the dimension of the die | 2019-08-01 |
20190233754 | HIGH VISCOSITY BASE STOCK COMPOSITIONS - Methods are provided for producing Group III base stocks having high viscosity and also having one or more properties indicative of a high quality base stock. The resulting Group III base stocks can have a viscosity at 100° C. and/or a viscosity at 40° C. that is greater than the corresponding viscosity for a conventional Group III base stock. Additionally, the resulting Group III base stocks can have one or more properties that are indicative of a high quality base stock. | 2019-08-01 |
20190233755 | Bimodal Bottlebrush Poly(alpha olefin) Solid Lubricants - Bottlebrush poly(alpha olefin)s of high carbon number, greater than 12 such as poly(octadecene), are used as a thickener for a synthetic base oil grease lubricant that is based on oligomerized alpha olefin with carbon number from 7 to 12, such as oligo(decene). Dispersion aids are not required in the present lubricants because poly(octadecene) can be dissolved in oligo(decene). The lubricant is a solid grease formed by percolation/network of the poly(octadecene) crystals, at a sufficient concentration, after the crystallization of poly(octadecene), and water resistant having oxidation/high temperature stability. | 2019-08-01 |
20190233756 | LUBRICATING OIL COMPOSITION FOR INDUSTRIAL MACHINE, AND LUBRICATING METHOD - A lubricating oil composition for industrial machines containing a base oil (A) and a specific acylglycerol (B) and having excellent brake squeal preventing performance, and a lubrication method using the composition. | 2019-08-01 |
20190233757 | GRAFT COPOLYMERS BASED ON POLYOLEFIN BACKBONE AND METHACRYLATE SIDE CHAINS - A graft copolymer can include, in its backbone, at least one segment having repeating units obtainable by ring-opening metathesis polymerization (ROMP) of an optionally substituted cycloalkene, and at least one segment comprising repeating units obtainable by atom transfer radical polymerization (ATRP) of a (meth)acrylate. The corresponding graft copolymer is highly suitable for use as an oil additive in internal combustion engines, in particular, in combustion engines which are operated for longer periods of time at substantially constant operating temperatures. | 2019-08-01 |
20190233758 | METHOD FOR LUBRICATING INTERNAL COMBUSTION ENGINE - A method for lubricating an internal combustion engine, the method including: supplying a lubricating oil composition to a cylinder of an internal combustion engine, wherein the internal combustion engine has a mean effective pressure of no less than 1.3 MPa, wherein an integrated intensity ratio of peaks of CaO in a X-ray diffraction spectrum of an ash is no more than 16.5%, the ash being obtained by incinerating the lubricating oil composition in an air at 950° C. | 2019-08-01 |
20190233759 | REFRIGERATING MACHINE OIL AND COMPOSITION FOR REFRIGERATING MACHINES - The present invention relates to a refrigerator oil containing (A) a mineral oil having a kinematic viscosity at 40° C. of 0.50 mm | 2019-08-01 |
20190233760 | METHOD FOR APPLYING A TREATMENT AGENT TO A SUBSTRATE - A method for applying a treatment agent to a substrate, wherein the treatment agent is bound to a solid polymeric particle at a first pH, and wherein the substrate is contacted with the solid polymeric treatment particles under conditions such that the treatment agent is released from the solid polymeric treatment particles. | 2019-08-01 |
20190233761 | SOLID CLEANING COMPOSITION - A solid cleaning composition includes a solidified surfactant blend. The solidified surfactant blend includes (1) at least one metal alkyl ether sulfate having the formula: | 2019-08-01 |
20190233762 | MULTIUSE, HIGH-EFFICIENCY AND ENVIRONMENT-FRIENDLY CLEANING SOLUTION AND PREPARATION METHOD THEREFOR - A multiuse, high efficiency and environment-friendly cleaning solution and preparation method therefor, the cleaning solution comprising the following components: sodium polyacrylate, surface active agent and deionized water. The surface active agent comprises a combination of any two or more of alkyl-polyoxyethylene ether acetate, plant polyenoid phenol polyoxyethylene ether or laurinol polyoxyethylene ether. The cleaning solution has a wide range of cleaning uses, and may exhibit a good cleaning effect when applied in multiple fields. | 2019-08-01 |
20190233763 | LIQUID FABRIC ENHANCERS COMPRISING BRANCHED POLYESTER MOLECULES - Liquid fabric enhancer compositions that include branched polyester compounds. Methods of making and using same. | 2019-08-01 |
20190233764 | PARTICULATE LAUNDRY SOFTENING WASH ADDITIVE - A composition including a plurality of particles, the particles including: about 25% to about 94% by weight a water-soluble carrier; about 5% to about 45% by weight of a branched polyester; and an optional deposition aid; wherein each of the particles can have a mass from about 1 mg to about 1 g. | 2019-08-01 |
20190233765 | PROCESS FOR THE PREPARATION OF MICROCAPSULES - The present invention relates to a new process for the preparation of melamine-formaldehyde free microcapsules. Microcapsules obtainable by said process are also an object of the invention. Perfuming compositions and consumer products comprising said capsules, in particular perfumed consumer products in the form of home care or personal care products, are also part of the invention. | 2019-08-01 |
20190233766 | USE OF ENZYMES, COMPOSITION AND METHOD FOR REMOVING SOIL - The present invention concerns the use of enzymes for removing soil from a surface during the rising of the surface, wherein the rinsing is following a washing cycle. The invention further concerns a rinse aid composition for rinsing the surface and a method for removing soil from the surface during a rinsing step. | 2019-08-01 |
20190233767 | SURFACTANTS THAT IMPROVE THE CLEANING OF LIPID-BASED STAINS TREATED WITH LIPASES - Described are compositions and methods relating to the removal of oily stains from fabrics and other surfaces using a lipase in combination with a selected surfactant to mediate the release of fatty acids generated by the lipase. The compositions and methods have application in, e.g., laundry cleaning and dishwashing. | 2019-08-01 |
20190233768 | STABLE UNIT DOSE DETERGENT PACS - Stable unit dose detergent pacs are provided which are less prone to leakage or breakage and more aesthetically pleasing during handling. The unit dose pacs include a water-soluble container formed from a water-soluble or water-dispersible film and a wash composition encapsulated in the container. According to one embodiment, the wash composition includes an anionic surfactant present at from about 2% to about 35%, a non-ionic surfactant present at from about 2% to about 30%, and a solvent system present at from about 37.5% to about 80%, characterized in that the solvent system is composed of water and a single non-aqueous solvent only, or composed of water, a single non-aqueous solvent, and a residual solvent (less than 5%) only. | 2019-08-01 |
20190233769 | DISINFECTANT COMPOSITION - A disinfectant composition imparting a residual biocidal property, the composition including: i) a polymer binder, wherein the polymer binder is an oxazoline homopolymer or an extended or a modified polymer based on an oxazoline homopolymer; ii) a biocidal quaternary ammonium compound; iii) a polyacrylate polymer having a molecular weight from about 100 to about 5,000 g/mol; iv) a glycol ether of formula R1O(R2O)nR3 (I) wherein R1 is a linear or branched C4, C5 or C6 alkyl, a substituted or unsubstituted phenyl, preferably n-butyl R2 is ethyl or isopropyl, preferably isopropyl R3 is hydrogen or methyl, preferably hydrogen n is 1, 2 or 3, preferably 1 or 2; and v) preferably a carrier. | 2019-08-01 |
20190233770 | IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS - The invention relates to an encapsulated fragrance composition including at least one microcapsule dispersed in a dispersion medium, said at least one microcapsule including a fragrance oil core and a positively charged shell, which includes a reaction product of at least one at least difunctional anionically modified isocyanate with an amine or alcohol, preferably a polyamine, and wherein the shell is formed around droplet of core material that is stabilized with a positively charged colloidal stabilizer. Furthermore, the invention relates to a process of formation of said encapsulated fragrance compositions. | 2019-08-01 |
20190233771 | STRIPPING COMPOSITIONS FOR REMOVING PHOTORESISTS FROM SEMICONDUCTOR SUBSTRATES - This disclosure relates to compositions containing 1) at least one water soluble polar aprotic organic solvent; 2) at least one quaternary ammonium hydroxide; 3) at least one carboxylic acid; 4) at least one Group II metal cation; 5) at least one copper corrosion inhibitor selected from the group consisting of 6-substituted-2,4-diamino-1,3,5-triazines; and 6) water. The compositions can effectively strip positive or negative-tone resists or resist residues, and be non-corrosive to bumps and underlying metallization materials (such as SnAg, CuNiSn, CuCoCu, CoSn, Ni, Cu, Al, W, Sn, Co, and the like) on a semiconductor substrate. | 2019-08-01 |
20190233772 | SOLIDIFYING LIQUID ANIONIC SURFACTANTS - The invention relates to solidification of liquid anionic surfactants with a binder, carrier, or both binder and carrier to form a solidified surfactant composition. In particular, the invention relates to solidification of liquid surfactants utilizing drying device(s), wherein the feed composition contains at least one liquid surfactant and the binder, carrier, or binder and carrier to form a solidified surfactant composition. The solidified surfactant compositions can be useful in various cleaning compositions. | 2019-08-01 |
20190233773 | SOLIDIFYING LIQUID AMINE OXIDE, BETAINE, AND/OR SULTAINE SURFACTANTS WITH A CARRIER - The invention relates to solidification of liquid amine oxide, betaine, and/or sultaine surfactants with a carrier to form a solidified surfactant composition. In particular, the invention relates to solidification of liquid surfactants utilizing drying device(s), wherein the feed composition contains at least one liquid surfactant and a carrier to form a solidified surfactant composition. The solidified surfactant compositions can be useful in various cleaning compositions. | 2019-08-01 |
20190233774 | SOLIDIFYING LIQUID AMINE OXIDE, BETAINE, AND/OR SULTAINE SURFACTANTS WITH A BINDER AND OPTIONAL CARRIER - The invention relates to solidification of liquid amine oxide, betaine, and/or sultaine surfactants with a binder to form a solidified surfactant composition. In particular, the invention relates to solidification of liquid surfactants utilizing drying device(s), wherein the feed composition contains at least one liquid surfactant and a binder and optional carrier to form a solidified surfactant composition. The solidified surfactant compositions can be useful in various cleaning compositions. | 2019-08-01 |
20190233775 | CLEANING COMPOSITION THAT PROVIDES RESIDUAL BENEFITS - A composition for use on a hard surface. The composition has: (i) at least 7.5 wt. % of at least one surfactant selected; (ii) a blend of linear primary alcohols, or a blend of ethoxylated linear primary alcohols, wherein each alcohol of the non-ethoxylated blend or ethoxylated blend includes a carbon chain containing 9-17 carbons; (iii) a transport rate factor of less than about 55 seconds; and (iv) an adhesion time of greater than about 8 hours. | 2019-08-01 |
20190233776 | NON-CORROSIVE CLEANING COMPOSITION - A cleaning composition, which is self-adhering upon application to a hard surface, is provided. The cleaning composition includes an adhesion promoter, water and a sufficient amount of a basic agent, such that a mixture of the composition with deionized water has a pH of at least about 10. The adhesion promoter typically includes one or more organic compounds, each containing at least one hydrophilic group. The cleaning compositions may also include at least one surfactant selected from the group of: anionic, nonionic, cationic, amphoteric, and/or zwitterionic surfactants; where one or more of the surfactants may serve all or in part as the adhesion promoter. | 2019-08-01 |
20190233777 | MICROEMULSION REMOVERS FOR ADVANCED PHOTOLITHOGRAPHY - The present invention provides a microemulsion remover comprising, based on the total weight of the microemulsion remover, 1) from 10% to 60%, at least one organic solvent, ii) from 10% to 50%, at least one co-solvent, iii) from 0.1% to 10%, at least one base, iv) from 0.1% to 10%, at least one oxidizer, v) from 0.1% to 10%, at least one surfactant, and vi) water. | 2019-08-01 |
20190233778 | DETERGENT COMPOSITION HAVING A FLOW LIMIT - The production of a flow limit in liquid surfactant compositions by way of the use of a micro emulsion containing, in each case based on the total weight of the emulsion, a) a liquid phase, b) a total quantity of 10 wt % to 99.0 wt % of at least one non-polymer organic thickening agent having a molecular weight in the range from 100 g/mol to 500 g/mol as an emulsified phase, c) a total quantity of 0.001 wt % to 89.0 wt % of a surfactant system containing at least one non-ionic surfactant. | 2019-08-01 |
20190233779 | UNITARY LAUNDRY DETERGENT ARTICLE - A water-soluble unitary laundry detergent article that contains two or more surfactant-containing non-fibrous sheets with a fabric hueing agent located between such non-fibrous sheets. | 2019-08-01 |
20190233780 | WATER-SOLUBLE ARTICLES AND RELATED PROCESSES - Water-soluble unit dose articles and processes for making such articles, the articles having perimeters that define shapes able to form a tessellated pattern. | 2019-08-01 |
20190233781 | PLURALITIES OF WATER-SOLUBLE ARTICLES AND RELATED PROCESSES - Water-soluble unit dose articles that include fibrous elements. First and second articles that differ with regard to compositional and physical features. Processes for making such articles. | 2019-08-01 |
20190233782 | UNITARY LAUNDRY DETERGENT ARTICLE HAVING FIBROUS SUBSTRATES - A method of laundering fabric having the following steps: a) providing a water-soluble unit dose article; b) providing a surfactant; c) diluting a dose of the water-soluble unit does article in water by a factor of greater than about 500 to form a wash liquor, the resulting wash liquor having from about 50 ppm to about 2800 ppm of surfactant; and d) washing one or more fabrics in the resulting wash liquor. | 2019-08-01 |
20190233783 | WATER-SOLUBLE UNIT DOSE ARTICLES COMPRISING PERFUME - Described herein is a household care composition, which delivers active agents onto fabric, in the form of a water-soluble unit dose article comprising a water-soluble fibrous structure and a perfume, as well as methods for making the article and methods for treating fabrics using the article. | 2019-08-01 |
20190233784 | WATER-SOLUBLE UNIT DOSE ARTICLES COMPRISING ENZYME - Described herein is a household care composition, which delivers active agents onto fabric, in the form of a water-soluble unit dose article comprising a water-soluble fibrous structure and a concentrated enzyme composition, as well as methods for making the article and methods for treating fabrics using the article. | 2019-08-01 |
20190233785 | WATER-SOLUBLE UNIT DOSE ARTICLES COMPRISING PERFUME - Described herein is a household care composition, which delivers active agents onto fabric, in the form of a water-soluble unit dose article comprising a water-soluble fibrous structure and an encapsulated perfume composition, as well as methods for making the article and methods for treating fabrics using the article. | 2019-08-01 |
20190233786 | DRYER SHEETS COMPRISING BRANCHED POLYESTER POLYMERS - The present invention relates to dryer sheets comprising branched polyester polymers and methods of making and using such dryer sheets. Such dryer sheets, can comprise a variety substrate materials and provide the desired level of performance without the technical and economic drawbacks of conventional dryer sheets. | 2019-08-01 |
20190233787 | BIOREACTOR - A bioreactor comprising a housing defining a perfusion chamber, the housing including at least one port, wherein the at least one port is coupled to the housing, and a sample holder positioned within the perfusion chamber. A bioreactor and spheroid-based biofabrication method for making perfusible tissue constructs and perfusing them. | 2019-08-01 |
20190233788 | Production Method For And Use Of Polymer Thin-Film Culture Plat For Production Method For And Application Of Cell Sheet - The present invention provides a culture plate comprising a copolymer formed from a first monomer for forming a thin film having high surface free energy and a second monomer for forming a thin film having low surface free energy, a method for producing the culture plate, and a method for producing and transferring a cell aggregate in the form of a cell sheet by using the culture plate. The present invention has the effect of producing a cell aggregate in the form of a cell sheet through an easy and simple process in comparison with prior art. | 2019-08-01 |
20190233789 | PILLAR UNIT FOR BIO CHIP - Provided is a pillar unit for a bio chip. The pillar unit for a bio chip according to the present invention is to form a bio chip along with a well plate, in which a culture medium is accommodated, wherein the bio chip analyzes samples of biological micro-substances such as cells, and may include: a plate-form substrate including a plurality of holder parts, which is spaced apart from each other, arranged vertically and horizontally, and includes a holding space, to which an object is inserted and fixed, wherein each of the holder parts includes transformation slits so that the holder part may be transformed and restored while the object is accommodated in the holding space; and a plurality of pillars corresponding to the above object which is accommodated in the holding space of the substrate, wherein one end of the pillar is combined with each holder part and is detachable, and the other end of the pillar includes the sample. | 2019-08-01 |
20190233790 | METHOD OF CULTURING EUKARYOTIC CELLS - An apparatus and method to maintain pH within a range conducive for cell growth in a bicarbonate-containing cell culture system without the addition of base. The method relies on the gas transfer characteristics of the bioreactor system to modulate the CO | 2019-08-01 |
20190233791 | MICROFLUIDIC DEVICE FOR STUDYING SHEAR STRESS AND TUMOR MIGRATION IN MICROCHANNEL AND METHOD OF ANALYZING CELLS USING THE MICROFLUIDIC DEVICE - A microfluidic device for studying shear stress and tumor migration in a microchannel includes: a microchamber; a microchannel including an inlet and an outlet for a fluid and formed on the periphery of the microchamber and making the fluid pass through the periphery of the microchamber; and a plurality of groups of bridge channels connecting the microchannel and the microchannel at a plurality of locations in the microchannel and a cross-sectional area of the bridge channel is smaller than that of the microchannel. | 2019-08-01 |
20190233792 | CELL CULTURE VESSEL - The present invention provides a cell culture vessel having a surface coated with a copolymer including a repeating unit containing a group represented by the following formula (a), a repeating unit containing a group represented by the following formula (b), and a repeating unit containing a group represented by the following formula (c) (wherein U | 2019-08-01 |
20190233793 | BIOCOMPATIBLE MATRICES FOR THE TRANSFER OF BIOLOGICAL MOLECULES - There is provided a biocompatible material for delivering a biological molecule to target location, the material comprising: —a hydrogel matrix material, —a divalent cation-phosphate nanoparticle (in particular Calcium Phosphate), —and a biological molecule (in particular a nucleic acid) complexed with the nanoparticle; wherein the nanoparticle is embedded within the hydrogel matrix material. The biocompatible material, particularly when in a 3D form, can be used in the treatment of various diseases. A preferred method of embedding the nanoparticles and biological molecules in the matrix is by electrophoretic transfer. | 2019-08-01 |
20190233794 | Stem Cell Aggregates and Methods for Making and Using - The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stem cells but can differentiate into cell types of at least two of ectodermal, undo dermal, and mesodermal embryonic germ layers, e.g., stem cells. | 2019-08-01 |
20190233795 | TRANSCRIPTION FACTORS CONTROLLING DIFFERENTIATION OF STEM CELLS - Forced expression of a handful of transcription factors (TFs) can induce conversions between cell identities; however, the extent to which TFs can alter cell identity has not been systematically assessed. Here, we assembled a human TFome, a comprehensive expression library of 1,578 human TF clones with full coverage of the major TF families. By systematically screening the human TFome, we identified 77 individual TFs that induce loss of human-induced-pluripotent-stem-cell (hiPSC) identity, suggesting a pervasive ability for TFs to alter cell identity. Using large-scale computational cell type classification trained on thousands of tissue expression profiles, we identified cell types generated by these TFs with high efficiency and speed, without additional selections or mechanical perturbations. TF expression in adult human tissues only correlated with some of the cell lineage generated, suggesting more complexity than observation studies can explain. | 2019-08-01 |
20190233796 | Generation of Inner Ear Cells - Methods for generating cells of the inner ear, e.g., hair cells and supporting cells, from stem cells, e.g., mesenchymal stem cells, are provided, as well as compositions including the inner ear cells. Methods for the therapeutic use of the inner ear cells for the treatment of hearing loss are also described. | 2019-08-01 |
20190233797 | HLA CLASS I-DEFICIENT NK-92 CELLS WITH DECREASED IMMUNOGENICITY - Described herein are modified NK-92 cells comprising a genetic alteration to decrease beta-2-microglobulin (B2M) expression in NK-92 cells to reduce the levels of HLA class I expression; methods of generating such cells; and methods of treating a subject, e.g., that has cancer, with the B2M-modified NK-92 cells. | 2019-08-01 |
20190233798 | Immortalization of Epithelial Cells and Methods of Use - The present invention is directed towards methods of culturing non-keratinocyte epithelial cells, with the methods comprising culturing non-keratinocyte epithelial cells in the presence of feeder cells and a calcium-containing medium while inhibiting the activity of Rho kinase (ROCK) in the feeder cell, the non-keratinocyte epithelial cells or both during culturing. | 2019-08-01 |
20190233799 | VACCINES AND PHARMACEUTICAL COMPOSITIONS AGAINST FOOT-AND-MOUTH DISEASE VIRUS - This application is directed generally to foot-and-mouth disease virus (FMDV) 3C proteases that have been modified by mutating a polynucleotide sequence coding for the FMDV 3C protease. The modified FMDV proteases exhibit proteolytic activity on FMDV P1 precursor protein and exhibit a reduction in one or more toxic or inhibitory properties associated with an unmodified FMDV 3C protease on a host cell used to recombinantly produce it. Vectors carrying polynucleotides encoding modified FMDV 3C protease sequences can induce production of FMDV virus-like particles in a host cell when expressed in the host cell. The modified FMDV 3C proteases can generally be used to produce immunogenic FMDV preparations capable of inducing an immune response against FMDV. | 2019-08-01 |
20190233800 | Microorganisms Engineered to Use Unconventional Sources of Phosphorous or Sulfur - Disclosed are genetically engineered organisms, such as yeast and bacteria, that have the ability to metabolize atypical phosphorus or sulfur sources. Fermentation methods using the genetically engineered organisms are also described. The fermentation methods are robust processes for the industrial bioproduction of a variety of compounds, including commodities, fine chemicals, and pharmaceuticals. | 2019-08-01 |
20190233801 | LACCASE PRODUCING COMPOSITION - The present invention provides a novel method for improving microbial laccase production, which relates to the field of microbial fermentation. The present invention is to add β-carotene and other types of carotenoids, or microorganisms that producing carotenoids, or mixture comprising carotenoids into fermentation system during fermentation of | 2019-08-01 |
20190233802 | YEAST STRAINS PRODUCING MAMMALIAN-LIKE COMPLEX N-GLYCANS - Described herein are methods and genetically engineered fungal cells useful for producing target molecules containing mammalian-like complex N-glycans or containing intermediates in a mammalian glycosylation pathway. | 2019-08-01 |
20190233803 | NOVEL ESTERASES AND USES THEREOF - The present invention relates to novel esterase, more particularly to esterase variants having improved thermostability compared to the esterase of SEQ ID NO: 1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate. | 2019-08-01 |
20190233804 | COMPOSITIONS AND METHODS COMPRISING A LIPOLYTIC ENZYME VARIANT - The present invention provides lipolytic enzyme variants. Specifically, the present invention provides lipolytic enzyme variants having two, three, or more modifications as compared to a parent lipolytic enzyme and having at least one improved property. In addition, the present invention provides compositions comprising a lipolytic enzyme variant of the invention. The present invention also provides methods of cleaning using compositions comprising a lipolytic enzyme variant of the invention. | 2019-08-01 |
20190233805 | TARGETABLE PROTEINS FOR EPIGENETIC MODIFICATION AND METHODS FOR USE THEREOF - Provided herein are fusion proteins comprising a catalytically inactive Cas9 domain and an effector domain. The fusion proteins of the present invention can be used to, for example, produce epigenetic modifications at target chromatin sites. Nucleic acids and expression vectors encoding the fusion proteins, as well as cells comprising the fusion proteins, are also provided herein. | 2019-08-01 |
20190233806 | CONDITIONAL ACTIVATION OF NUCLEIC ACID-GUIDED ENDONUCLEASES - The present disclosure provides, in some embodiments, methods and compositions that use secondary nucleic acid structures for regulating RNA-guided endonuclease activity and/or DNA-guided endonuclease activity. | 2019-08-01 |
20190233807 | METHOD FOR MANUFACTURING A STABLE AQUEOUS SOLUTION OF BETA-AMYLASE, AQUEOUS SOLUTION OBTAINED AND USES THEREOF - The present invention relates to a method for stabilising an aqueous solution of β-amylase, in particular by the use of glycerol, potassium sorbate and sodium carbonate. Said cocktail of additives is particularly effective at maintaining the enzymatic activity of β-amylase over time. Another aim of the present invention consists of using said cocktail for the specific function of maintaining the enzymatic activity of the β-amylase. Another aim of the present invention is to provide an aqueous solution of β-amylase containing the aforementioned cocktail. A final aim of the present invention consists of using said β-amylase aqueous solution in bread-making, in malting, as a food additive, as a digestive agent, for sweetener production, in pharmacy and, finally, for maltose and maltose-enriched syrup production. | 2019-08-01 |
20190233808 | PURIFICATION OF ACTIVE SOLUBLE RECOMBINANT MATRIX METALLOPROTEINASE IN ESCHERICHIA COLI - A method for purifying activated human MMP in | 2019-08-01 |
20190233809 | DEVICE AND METHODS FOR DELIVERY OF BIPHASIC ELECTRICAL PULSES FOR NON-THERMAL ABLATION - The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue. | 2019-08-01 |
20190233810 | Method for Isolating Nucleic Acids with Bivalent Cations and Elution with a Cation Chelating Agent - The present invention relates to improved methods of isolating nucleic acids. In particular the method comprises the use of a wash buffer comprising bivalent cations prior to elution of the nucleic acid. | 2019-08-01 |
20190233811 | METHOD FOR OBTAINING ANTIBODY - The present invention relates to a method for obtaining an antibody from an avian B cell antibody library, comprising the following steps (a) to (d):
| 2019-08-01 |
20190233812 | PROBE LIBRARY CONSTRUCTION - The present invention generally relates to systems and methods for producing nucleic acids. In some aspects, relatively large quantities of oligonucleotides can be produced, and in some cases, the oligonucleotides may have a variety of different sequences and/or lengths. For instance, a relatively small quantity of oligonucleotides may be amplified to produce a large amount of nucleotides. In one set of embodiments, oligonucleotides may be amplified using PCR, then transcribed to produce RNA. The RNA may then be reverse transcribed to produce DNA, and optionally, the RNA may be selectively degraded or removed, relative to the DNA. In one set of embodiments, the oligonucleotides may be chemically modified. These modifications may include, but are not limited, to the adding of fluorescent dyes or other signaling entities. | 2019-08-01 |
20190233813 | A METHOD OF DISCOVERING SPECIFIC FUNCTIONAL ANTIBODIES - The invention relates to a method for discovering specific functional antibodies, in particular to a method for discovering specific functional antibodies based on sequence composition and frequency analysis of variable regions of immune host antibodies. Compared with conventional high-throughput antibody sequencing method, this method can quickly and accurately obtain the full-length sequence of the variable region of antibody containing candidate CDR3, the success rate of antibody gene pairing is high and it is suitable for the detection of few samples, and improves the efficiency of obtaining specific functional antibodies. | 2019-08-01 |
20190233814 | NOVEL CRISPR ENZYMES AND SYSTEMS - The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. | 2019-08-01 |
20190233815 | METHODS AND COMPOSITIONS FOR TREATING INSECTS - Provided herein are methods and compositions for modulating gene expression in insects by administering a composition comprising an RNA effector molecule and a delivery agent. Methods are provided for controlling pest populations by inhibiting insect growth, development, survival, reproduction and/or viability. Also provided herein are methods for treating or preventing disease in an insect caused by a pathogen or by external factors (e.g., pollution, environment, stress, weather, etc.). | 2019-08-01 |
20190233816 | STRUCTURE-GUIDED CHEMICAL MODIFICATION OF GUIDE RNA AND ITS APPLICATIONS - The disclosure relates to compositions comprising and methods for chemical modification of single guide RNA (sgRNA), tracrRNA and/or crRNA used individually or in combination with one another or Cas system components. Compositions comprising modified ribonucleic acids have been designed with chemical modification for even higher efficiency as unmodified native strand of sgRNA. Administration of modified ribonucleic acids will allow decreased immune response when administered to a subject, increased stability, increased editing efficiency and facilitated in vivo delivery of sgRNA via various delivery platforms. The disclosure also relates to methods of decreasing off-target effect of CRISPR and a CRISPR complex. | 2019-08-01 |
20190233817 | ORGANIC COMPOSITIONS TO TREAT APOC3-RELATED DISEASES - The present disclosure relates to compositions and methods for treating APOC3-related diseases such as: hypertriglyceridemia (e.g., Type V Hypertriglyceridemia), abnormal lipid metabolism, abnormal cholesterol metabolism, atherosclerosis, hyperlipidemia, diabetes, including Type 2 diabetes, obesity, cardiovascular disease, and coronary artery disease, among other disorders relating to abnormal metabolism or otherwise, using a therapeutically effective amount of a RNAi agent to APOC3. | 2019-08-01 |
20190233818 | IMPROVED PNA PROBE - Disclosed herein are improved PNA based monomers, nucleobases, oligomers and probes for use in a variety of different methods of analysing nucleic acids. Further, the disclosure provides methods of preparing the modified and improved PNA molecules as well as methods of using the same. | 2019-08-01 |
20190233819 | A METHOD OF RELEASING THE SUPPRESSION OF EGG MATURATION IN ECONOMICALLY-IMPORTANT PRAWN/SHRIMP SPECIES - An object of the present invention is to provide a method for releasing oocyte maturation regulation by suppressing expression of a gene capable of regulating oocyte maturation in shrimps by the RNA interference method. The present invention provides a method for blocking oocyte maturation inhibition in farmed shrimps to be used as spawners (hereafter, “farmed shrimp”), comprising suppressing the expression of a vitellogenesis-inhibiting hormone (VIH) gene in shrimps by RNA interference using double-stranded RNA (dsRNA) targeting mRNA of the vitellogenesis-inhibiting hormone gene in farmed shrimps. | 2019-08-01 |
20190233820 | NANOPARTICLES FUNCTIONALIZED WITH GENE EDITING TOOLS AND RELATED METHODS - This disclosure relates to compositions and methods for editing or altering target nucleotide sequences based on nanoparticle delivery vehicles. The compositions and methods can be applied to influence the functional expression of target gene products encoded by DNA and/or RNA. In some embodiments, the altered gene sequences are useful to normalize and regulate the function of target cells. | 2019-08-01 |
20190233821 | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA) - The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism. | 2019-08-01 |
20190233822 | FUNCTIONAL LIGANDS TO BIOCIDES - The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as biocide molecules. | 2019-08-01 |
20190233823 | COMPOUNDS FOR DETECTING AND TREATING MYCOPLASMA HYOPNEUMONIAE - The present invention relates to aptamers, polynucleotides, and nucleic acid molecules, which include a polynucleotide sequence capable of specifically binding polypeptides participating in | 2019-08-01 |
20190233824 | PD-1 SPECIFIC APTAMERS - The present disclosure relates to PD1-specific aptamers and methods of treating cancer. | 2019-08-01 |
20190233825 | METHODS OF MODULATING CYTOSOLIC DNA SURVEILLANCE MOLECULES - The present invention generally relates to methods of eliciting an immune response in a subject by activating specific innate immunity signaling molecules and pathway. In particular, an immunomodulator composition is used to stimulate innate immunity signaling molecules and pathways. | 2019-08-01 |
20190233826 | RNA INTERFERENCE IN OCULAR INDICATIONS - The present invention relates to ocular administration of sd-rxRNA and rxRNAori molecules. | 2019-08-01 |
20190233827 | MODULATION OF PREKALLIKREIN (PKK) EXPRESSION - Disclosed herein are antisense compounds and methods for decreasing PKK mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate PKK-associated diseases, disorders, and conditions. | 2019-08-01 |
20190233828 | Methods of Treating a Wound Using Epigenetic Regulation - Methods of treating wounds in a subject using one or both of a DNA methyltransferase 1 (DNMT1) inhibitor or a nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) inhibitor, and compositions for use in these methods. | 2019-08-01 |
20190233829 | METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY - Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for COX-2. | 2019-08-01 |
20190233830 | Method for Regulating Expression of Protein of Interest in Bacillus subtilis - The present disclosure relates to a method for regulating expression of protein of interest in | 2019-08-01 |
20190233831 | PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF - The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells. | 2019-08-01 |
20190233832 | METHOD FOR INTRODUCING SUBSTANCE INTO PLANT CELL USING PLASMA - It was found that bringing a substance into contact with a plant cell after the plant cell is treated with plasma makes it possible to easily and highly efficiently introduce the substance into the cell without causing a damae regardless of the types of the plant and tissue from which the plant cell is derived. | 2019-08-01 |
20190233833 | PLANT TOLERANCE TO LOW WATER, LOW NITROGEN AND COLD II - Polynucleotides incorporated into nucleic acid constructs have been introduced into plants and were ectopically expressed. The encoded polypeptides of the invention have been shown to confer at least one regulatory activity and confer earlier flowering, longer floral organ retention, increased cold tolerance, greater tolerance to water deprivation, altered carbon-nitrogen balance sensing, increased low nitrogen tolerance, and/or increased tolerance to hyperosmotic stress as compared to a control plant. | 2019-08-01 |
20190233834 | CONTROL OF PHENOTYPE IN PLANTS - The invention provides a compositions and methods for controlling phenotypic traits in plants. Genes of interest are placed under the control of a gene switch to allow inducible control or expression of a gene of interest “on-demand” by treatment of the plant with a chemical ligand. | 2019-08-01 |
20190233835 | CELL-PERMEABLE (CP)-CAS9 RECOMBINANT PROTEIN AND USES THEREOF - The present invention relates to providing cell-permeable (CP)-Cas9 recombinant protein and uses thereof. Preferably, the CP-Cas9 recombinant protein may be used as Cas9 nuclease for CRISPR/Cas9 system by utilizing the platform technology for macromolecule intracellular transduction. | 2019-08-01 |
20190233836 | MEANS AND METHODS TO INCREASE COUMARIN PRODUCTION - The present invention relates to the field of plant molecular biology, more particularly to the field of agriculture, even more particularly to the field of improving the yield of coumarins in plants. The present invention provides chimeric genes and constructs which can be used to enhance the coumarin yield. | 2019-08-01 |
20190233837 | TOMATO PLANTS WITH IMPROVED TRAITS - Tomato plants exhibiting fruit with increased BRIX content are provided, together with methods of producing, identifying, or selecting plants or germplasm with an increased BRIX phenotype and lacking undesirable leaf necrosis. Such plants include tomato plants comprising introgressed genomic regions conferring increased BRIX without necrosis. Compositions, including novel polymorphic markers for detecting plants comprising introgressed alleles providing increased BRIX without necrosis, are further provided. | 2019-08-01 |
20190233838 | PLANT GENE FOR GRANULE DEVELOPMENT, MODIFIED CEREAL PLANTS AND GRAIN - There is provided a plant of domesticated | 2019-08-01 |
20190233839 | INCREASING PLANT GROWTH AND YIELD BY USING A PSAN SEQUENCE - Compositions and methods for improving plant growth are provided herein. Polynucleotides encoding photosystem I reaction center subunit N (PSAN) proteins, polypeptides encompassing PSAN proteins, and expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants are also provided. | 2019-08-01 |
20190233840 | INCREASING PLANT GROWTH AND YIELD BY USING AN ERF TRANSCRIPTION FACTOR SEQUENCE - Compositions and methods for improving plant growth are provided herein. Polynucleotides encoding ERF transcription factor proteins, polypeptides encompassing ERF transcription factor proteins, and expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants are also provided. | 2019-08-01 |
20190233841 | PERONOSPORA RESISTANCE IN SPINACIA OLERACEA - The present invention relates to an allele designated alpha-WOLF 15 which confers resistance to at least one | 2019-08-01 |
20190233842 | PROTEIN EXPRESSION FROM MULTIPLE NUCLEIC ACIDS - The current invention reports a method for the recombinant production of a secreted heterologous immunoglobulin in a CHO cell comprising the following steps: i) providing a CHO cell, which is adapted to growth in suspension culture, adapted to growth in serum-free medium, mycoplasma free, and virus free, ii) providing a vector comprising a prokaryotic origin of replication, a first nucleic add conferring resistance to a prokaryotic selection agent, a second nucleic acid encoding the heavy chain of said heterologous immunoglobulin, a third nucleic acid encoding the light chain of said heterologous immunoglobulin, a fourth nucleic acid conferring resistance to a eukaryotic selection agent, iii) transfecting said CHO cell, wherein said transfecting comprises a) transfecting said CHO cell with said vector comprising a fourth nucleic acid conferring resistance to a first eukaryotic selection agent, h) selecting a CHO cell by growth in cultivation medium containing said first eukaryotic selection agent, c) transfecting said selected CHO cell with said vector comprising a fourth nucleic acid conferring resistance to a second eukaryotic selection agent different to said first eukaryotic selection agent, d) selecting a CHO cell by selected growth in cultivation medium containing said first and said second eukaryotic selection agent, iv) cultivating said transfected CHO cell in a medium in the presence of said first and second eukaryotic selection agent, under conditions suitable for the expression of said second, and third nucleic acid, and v) recovering said secreted heterologous immunoglobulin from the cultivation medium. | 2019-08-01 |
20190233843 | TRANSPOSON SYSTEM AND METHODS OF USE - Disclosed are methods for the ex-vivo genetic modification of an immune cell comprising delivering to the immune cell, (a) a nucleic acid or amino acid sequence comprising a sequence encoding a transposase enzyme and (b) a recombinant and non-naturally occurring DNA sequence comprising a DNA sequence encoding a transposon. | 2019-08-01 |
20190233844 | SPATIOTEMPORAL REGULATORS - Provided herein, in some embodiments, are methods, compositions, systems and kits that enable spatiotemporal regulation of nucleic acid expression in engineered cells. | 2019-08-01 |
20190233845 | ADENOVECTORS FOR DELIVERY OF THERAPUETIC GENETIC MATERIAL INTO T CELLS - The invention provides adenoviral vectors and compositions for the highly efficient transduction of T cells. | 2019-08-01 |
20190233846 | METHODS OF ENHANCING CHROMOSOMAL HOMOLOGOUS RECOMBINATION - Described herein are methods of enhancing chromosomal homologous recombination to stimulate a loss of heterozygosity at a gene locus of interest in a living cell. These methods are driven by an enhancer component and a target-specific endonuclease component and proceed through a mechanism whereby: exogenous donor DNA that is homologous to the gene locus of interest is not introduced into the living cell; the desired allele of the gene locus of interest remains uncleaved; and the undesired allele is either uncleaved, cleaved at a single location, or cleaved at multiple locations. These methods have numerous applications, including the repair of risk alleles for disease prevention, the correction of heterozygous mutations in dividing cells, the design of cancer therapeutics, and the design of novel gene-drive strategies. | 2019-08-01 |
20190233847 | VARIANT RNA-GUIDED POLYPEPTIDES AND METHODS OF USE - The present disclosure provides (i) RNA-guided polypeptides (e.g., circular permuted Cas9 proteins) in which the N-terminal end of an N-terminal fragment of a parent RNA-guided polypeptide (e.g., a parent Cas9 protein) is fused (e.g., via linker) to the C-terminal end of the C-terminal fragment (thereby generating new N- and C-termini), (ii) conditionally active RNA-guided polypeptides (e.g., conditionally active circular permuted Cas9 proteins), and (iiii) Cas9 fusion polypeptides that include an internal insertion of a heterologous polypeptide; as well as methods that employ the above polypeptides. | 2019-08-01 |
20190233848 | METHODS AND MATERIALS FOR THE BIOSYNTHESIS OF DIOL ALCOHOLS AND RELATED COMPOUNDS - Methods and materials for the production of diol alcohols, such as 1,2-propanediol (1,2-PD) and derivatives and compounds related thereto. Also provided are products produced in accordance with these methods and materials. | 2019-08-01 |
20190233849 | METHODS AND MATERIALS FOR THE BIOSYNTHESIS OF HYDROXY FATTY ACID ANIONS AND/OR DERIVATIVES THEREOF AND/OR COMPOUNDS RELATED THERETO - Methods and materials for the production of hydroxy fatty acid anions, including 2-hydroxyisobutyric acid (2-HIBA), and/or derivatives thereof and compounds related thereto are provided. Also provided are products produced in accordance with these methods and materials. | 2019-08-01 |
20190233850 | METHODS AND MATERIALS FOR THE BIOSYNTHESIS OF BETA HYDROXY ACIDS AND DERIVATIVES AND COMPOUNDS RELATED THERETO - Methods and materials for the production of beta hydroxy acids, such as 3-hydroxypropanoic acid (3-HP) and derivatives and compounds related thereto are provided. Also provided are products produced in accordance with these methods and materials. | 2019-08-01 |
20190233851 | METHODS AND MATERIALS FOR THE BIOSYNTHESIS OF COMPOUNDS OF FATTY ACID METABOLISM AND RELATED COMPOUNDS - Methods and materials for the production of compounds involved in fatty acid metabolism, and/or derivatives thereof and/or compounds related thereto are provided. Also provided are products produced in accordance with the methods and materials of the present invention. | 2019-08-01 |