31st week of 2022 patent applcation highlights part 11 |
Patent application number | Title | Published |
20220241429 | Antifolate-Carrying Nanoparticles and Their Use in Medicine - The present invention provides a nanoparticle comprising: a core comprising a metal and/or a semiconductor; and a plurality of ligands covalently linked to the core, wherein said ligands comprise: (i) at least one dilution ligand comprising a carbohydrate, glutathione or an ethylene glycol-containing moiety; and (ii) a ligand of the formula D-L | 2022-08-04 |
20220241430 | MODIFIED VIRAL PARTICLES AND USES THEREOF - Provided herein are compositions and methods for adapting adeno-associated virus (AAV) particles comprising capsids of non-primate animal AAV, remote AAV, or a combination thereof. AAV adapted accordingly may be a viable gene therapy platform for the treatment of a patient in need thereof, and may be particularly useful in patients excluded from current treatment modalities involving current therapeutic AAV particles due to their high titer of antibodies against the current therapeutic AAV particles. | 2022-08-04 |
20220241431 | METHODS OF TREATMENT OF HLA-B27 RELATED INFLAMMATORY DISEASES AND COMPOSITIONS RELATED TO SAME - The present disclosure provides methods and compositions for treatment of an HLA-B27-associated autoimmune inflammatory disorder by administration of nucleic acid encoding HSP90 or an active fragment thereof. | 2022-08-04 |
20220241432 | ANTICANCER COMBINATIONS - Provided herein, inter alia, are compositions and kits comprising a bacterial cell and a tumor penetrating agent. Also provided are methods of treating cancer in a subject including the step of administering to the subject an effective amount of a bacterial cell and a tumor penetrating agent. Provided are methods of stimulating an immune system in a subject. The methods include administering to the subject an effective amount of a bacterial cell and a tumor penetrating agent. Also provided are methods of enhancing delivery of an anti-cancer agent to a tumor cell including the step of contacting the tumor cell with a bacterial cell, a tumor penetrating agent and an anti-cancer agent. | 2022-08-04 |
20220241433 | NERVE REGENERATION - The present application describes a method of regenerating nerve, which steps include generating a recombinant viral or plasmid vector comprising a DNA sequence encoding a member of a transforming growth factor superfamily of proteins operatively linked to a promoter; transfecting in vitro a population of cultured cells with the recombinant vector, resulting in a population of the cultured cells; and transplanting the transfected cells to an area near an injured nerve, such that expression of the DNA sequence within the area near the injured nerve causes regeneration of the nerve. | 2022-08-04 |
20220241434 | UBE3A GENES AND EXPRESSION CASSETTES AND THEIR USE - This invention relates to polynucleotides comprising UBE3A open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a UBE3A gene or aberrant activity of a UBE3A gene product in the subject, such as Angelman Syndrome. | 2022-08-04 |
20220241435 | METHODS FOR TREATING VEGF-RELATED CONDITIONS - An isolated or purified antisense oligonucleotide targeted to a nucleic acid molecule encoding vascular endothelial growth factor A (VEGF-A) pre-mRNA, wherein the antisense oligonucleotide has a nucleobase sequence selected from the list comprising SEQ ID NO: 1 to SEQ ID NO: 22 which has a modified backbone structure and sequences with at least 95% sequence identity to SEQ ID NO: 1-22 which have a modified backbone structure, and wherein the antisense oligonucleotide inhibits the expression of human VEGF-A. | 2022-08-04 |
20220241436 | COMPOSITIONS AND METHODS FOR TREATMENT OF CYSTIC FIBROSIS - Provided herein are polynucleotides, rAAV vectors, pharmaceutical compositions, and methods of making and using the same, e.g., for treatment of cystic fibrosis (CF). For example, the disclosure provides a recombinant adeno-associated vims (rAAV) that includes, in one embodiment, an AV.TL65 capsid protein and a polynucleotide that includes an F5 enhancer and a tg83 promoter operably linked to a CFTRΔR minigene, pharmaceutical compositions thereof, and methods of use thereof, e.g., for treatment of CF. | 2022-08-04 |
20220241437 | ATHEROSCLEROSIS IMAGING AGENTS AND METHODS OF USING THE SAME - Methods for detecting the presence of atherosclerotic structures in order to diagnose or prevent atherosclerosis are provided herein. In particular, it has been found that methylene blue injected intravenously acts as an excellent indicator because the compound targets high-risk plaque, atheroma, macrophages, and other atherosclerotic structures formed within the endothelial walls of a vessel of a subject. Because the compound provides a unique binding profile with uptake only in plaque or atheroma, and not the normal or healthy vascular interstitial tissue, methylene blue maintains a good plaque-to-background ratio for imaging purposes. This enables healthcare providers to determine the status of atherosclerosis development in vivo within a patient with higher certainty and at lower costs. The disclosed methods allow for high-resolution mapping of plaque build-up, plaque pathobiology, and other atherosclerotic structures within a vessel of a subject by using methylene blue as an imaging agent. | 2022-08-04 |
20220241438 | COMPOSITIONS AND METHODS FOR ASSESSING GUT FUNCTION - Compositions and methods for assessing gut function are disclosed. They are designed to provide accurate, rapid, point-of-care or in-community assessment of enteric dysfunction. | 2022-08-04 |
20220241439 | BIOTHIOL-ACTIVATABLE PROBE AND METHOD OF USE - A biothiol-activatable composition is disclosed that is configured to dissociate in the presence of a concentration of biomolecules that are excreted normally by a liver of a living subject comprising a noble metal nanoparticle, a reporter molecule, a linker molecule that is conjugated to the noble metal nanoparticle and to the reporter molecule, but displaceable in the presence of the biomolecules, and wherein the reporter molecule is released in the presence of the biomolecules. The noble nanoparticle is preferably a gold nanoparticle; the reporter molecule preferably comprises at least one of a fluorescent dye molecule, a radioactive molecule or an MRI agent and the linker molecule is preferably a thiol molecule displaceable by biothiols in the liver. In another aspect, the reporter molecule dissociates from the composition in the presence of a concentration of glutathione similar to what is found in liver sinusoids of a normally functioning liver. | 2022-08-04 |
20220241440 | LIGHTING DEVICE THAT DEACTIVATES DANGEROUS PATHOGENS WHILE PROVIDING VISUALLY APPEALING LIGHT - A lighting device configured to deactivate pathogens in an environment. The lighting device includes a housing, means for mounting the housing to a surface in the environment, one or more first light-emitting elements arranged in the housing and configured to each produce disinfecting light having a wavelength in a first range of wavelengths, and one or more second light-emitting elements arranged in the housing and configured to each produce disinfecting light having a wavelength in a second range of wavelengths different from the first range of wavelengths. The disinfecting light produced by the first light-emitting elements and the disinfecting light produced by the second light-emitting elements mix to form a combined light, the combined light being visible light other than white light. | 2022-08-04 |
20220241441 | UVC Shopping Cart Cleaner - A system and method for providing automated UVC cleaning of shopping carts is disclosed. The system includes a first enclosing tunnel for containing one or more shopping carts during cleaning, one or more automatically opening and closing doors for enclosing any access to the first enclosing tunnel, a door lock coupled to each of the automatically opening and closing doors, a conveyor subsystem for loading and unloading shopping carts for cleaning within the first enclosing tunnel, and one or more UVC light source emitters contained within the first enclosing tunnel. | 2022-08-04 |
20220241442 | GASPER KNOB SANITIZATION - An air gasper knob system for an overhead Passenger Service Unit (PSU) includes an annular gasper knob of a UV transparent material. The annular gasper knob defines an air passage therethrough, and extends about the air passage from a first annular end face to a second annular end face. The system also includes a UV illuminator mounted to the gasper knob, oriented to transmit UV illumination through the UV transparent material to sanitize exterior surfaces of the gasper knob. A method of sanitizing an air gasper knob comprises illuminating a gasper knob in an overhead PSU using UV illumination to destroy infectious agents on surfaces of the gasper knob. | 2022-08-04 |
20220241443 | HANDLE ASSEMBLY - A handle assembly includes a first support portion, a second support portion, and a rod portion extending between the first support portion and the second support portion. The rod portion having an outer surface. The handle assembly also includes a sensor array disposed in one of the first or second support portions. The sensor array is configured to detect if the handle assembly has been used. The handle assembly also includes a light board configured to produce germicidal UV light upon detection from the sensor array that the handle assembly has been used such that the handle assembly is configured to automatically sanitize the outer surface of the rod portion after the handle assembly has been used. | 2022-08-04 |
20220241444 | INACTIVATION APPARATUS AND INACTIVATION METHOD - Disclosed herein is an inactivation apparatus for inactivating microorganisms and/or viruses by emitting light. The inactivation apparatus comprises: a light irradiation unit including a light source configured to emit light having a wavelength range that inactivates microorganisms and/or viruses, the light source emitting the light in a space where a human is present and the microorganisms and/or viruses exists; and a controller unit configured to control irradiation of the light by the light source. The light is ultraviolet light having a wavelength range of 200 nm to 235 nm, and the controller unit controls the light source to limit an effective incident irradiance of the ultraviolet light on an eye of the human present in the space to be within a certain irradiance range. | 2022-08-04 |
20220241445 | SYSTEMS AND METHODS FOR DISINFECTION - A disinfecting system includes a housing. An ultraviolet light (UV) source is secured to the housing and configured to emit UV light for disinfection of a target. A processor is secured to the housing in communication with the UV light source. The processor is configured to activate the UV light source for a selected amount of time suitable for disinfection of the target. | 2022-08-04 |
20220241446 | Sanitizing Door Handle - Various implementations of the invention are directed toward a sanitizing door handle and/or components of such sanitizing door handle. Some implementations of the invention are directed toward a manual sanitizing door handle while some implementations of the invention are directed toward an auto-sanitizing door handle. According to some implementations of the invention, a sanitizing fluid is dispensed directly onto an exterior surface of the sanitizing door handle in connection with an operation of the door handle to sanitize the door handle. According to some implementations of the invention, a sanitizing fluid is dispensed directly onto a user's hand(s) in connection with an operation of the door handle to sanitize the user's hand(s). | 2022-08-04 |
20220241447 | ULTRAVIOLET LIGHT DECONTAMINATION ASSEMBLY - A new UVC sterilization device for elevator buttons, which comprises of several UVC LEDs on an enclosed polymer body, equipped with an infrared sensor to provide signals when an object comes within a certain distance, along with a controller printed circuit board that drives the unit by providing a constant current for the disinfection LEDs, as well as a battery. The infrared sensor is connected with the MCU control unit in the main body through the infrared detection unit. The MCU control unit is connected with the LEDs through the LED control unit. The main body is mounted on the elevator wall by two brackets. These brackets mechanically hold the main body in place and align the LED rays towards the buttons. The product is small and compact, easy to carry and install, and proven to be effective against microbes which would ultimately reduce bacterial and virus transmissions. | 2022-08-04 |
20220241448 | FAR UV C CAN LIGHT FIXTURE - A can type fixture including a housing adapted for insertion into a hole in a ceiling. An excimer bulb or plurality of excimer bulbs supported in the housing and adapted for emitting Far UV C radiation at a plurality of wavelengths. A filter or a plurality of filters adapted for removing Far UV C wavelengths harmful to humans. A reflector and/or a diffusion layer. A driver/power supply is supported by the housing. The driver/power supply is adapted for providing electrical power to the excimer bulb(s) and is in electrical communication with the excimer bulb(s). The driver/power supply may be adapted to dim the excimer bulb(s). An illumination element, such as an LED array may be supported in the housing. The fixture may also include a motion sensor, crowd density sensor, proximity sensor, and/or distance sensor and may communicate via IoT. | 2022-08-04 |
20220241449 | Closure Mechanisms and Seal Integrity Indicators for Sterilization Containers - Closure mechanisms for closing and sealing sterilization containers and indicators for indicating the seal integrity sterilization containers are provided. For example, a container closure mechanism may be configured to distribute a closure force along a gasket to seal a container lid to a container body. Further, a seal indicator may visibly indicate at the container exterior whether the container is sufficiently sealed to prevent an ingress of contaminants into the container. If the container is sufficiently sealed, the seal indicator is a first state, and if the sterilization container is not sufficiently sealed, the seal indicator is in a second state. Thus, the seal indicator undergoes a state change when the sterilization container transitions from unsealed to sealed or from sealed to unsealed, such that a user can ascertain whether the container is properly sealed to maintain sterility or whether the seal and sterility of the container have been compromised. | 2022-08-04 |
20220241450 | MAL-ODOR REMOVING COMPOSITION AND RELATED METHODS THEREOF - Aqueous compositions of one or more organoethoxysilanes dissolved in an aqueous solution with one or more alcohols, polyvinyl alcohol and one or more optional fragrances, which can present or eliminate malodor aroma from microogranisms, methods of preparing the mal-odor removing compositions, and/or methods of using the mal-odor removing compositions. The mal-odor removing aqueous compositions preferably being in an liquid form that leaves is capable of providing clear, dried coating or film upon applied surfaces that removes odors and prevents proliferation of odor causing bacteria, fungi and viruses. | 2022-08-04 |
20220241451 | System for Treating Air - A system for treating air includes a first vent and second vent and an air passage in fluid communication between the first and second vents. Air is drawn into the first vent, moved through the air passage, and expelled from the second vent. The air passage includes an ultraviolet-C (“UV-C”) chamber, comprising a UV-C source, and a filter located after the UV-C chamber in the air passage and exposed to the UV-C source. Air moved through the air passage is treated by the UV-C source and then the filter. Such system may be used to treat air containing coronavirus particles. | 2022-08-04 |
20220241452 | MODULAR CONTAMINATE CAPTURE AND STERILIZATION APPARATUS AND METHOD - An apparatus and method are provided for capturing and sterilizing contaminants, such as viruses and the like. Air containing the contaminants is drawn into the apparatus that comprises a housing having a customized number and arrangement of dissimilar treatment chambers to remove a particular contaminate targeted for removal. The treatment chambers are selected from a group of pre manufactured, self-contained chambers that are singularly or in combination inserted into the housing and within an air flow path created by a fan. The group of treatment chambers include a UV chamber, a temperature chamber and an ozone converter chamber. The customized arrangement of treatment chambers are each placed in the air flow path and programmed to provide customized sterilization of any type of contaminate while persons are present in the space being treated. | 2022-08-04 |
20220241453 | DEVICE FOR CREATING A HEALTHY MICROCLIMATE - The invention relates to apparatuses for air cleaning, sanitation and enrichment, in particular to apparatuses for providing healthful air and generating a healthful micro-climate, and can be used to generate a healthful micro-climate in residential, training, medical treatment and work premises, portable special purpose premises, such as airtight capsules to provide for household, medical and other needs of humans for the air cleaned from harmful impurities, useful in its chemical composition. | 2022-08-04 |
20220241454 | SINGLE USE, TOPICAL, HYDROPHILIC ART5ICLE WITH A HEMOSTATIC FOAM - A hemostatic surface application device having a region of hemostatic foam for contact with a patient's skin where a wound exists or is created, the device includes: a release layer, the release layer in contact with a hemostatic flexible foam section, and a structural foam layer having a front side and a back side surrounding the hemostatic flexible foam layer, forming a generally central hemostatic surface exposed through the front side of the surrounding structural foam layer, and a support layer adhered to the backside of the structural foam layer. | 2022-08-04 |
20220241455 | WOUND DRESSING - A wound dressing is provided, which includes a substrate and a plurality of silver particles. The substrate has a first surface and a second surface which are opposite to each other, and the substrate further includes a plurality of microstructures. A plurality of silver particles is embedded rather in the microstructures or in the gaps between the microstructures, between first surface and the second surface. The wound dressing has a moisture vapor transmission rate being about 4000-20000 g/(m | 2022-08-04 |
20220241456 | MEDICAL TAPE USING A FILM-FORMING BASE PORTION AND METHOD FOR MANUFACTURING THE SAME - There is provided a method for manufacturing a medical tape that has a high effect of alleviating a persistent skin irritation during an application duration caused by a residual shrink force. | 2022-08-04 |
20220241457 | MULTI-PUTTY BONE HEMOSTATIC AND ADHESIVE COMPOSITIONS FOR USE IN METHODS OF INSTALLING AND SECURING SURGICAL HARDWARE IN BONES - Provided herein are bone hemostatic and adhesive compositions for use in surgical procedures comprising a variety of disclosed particles. Also provided are related compositions, including surgical hardware, surgical kits and packages, as well as methods of making and using the compositions. | 2022-08-04 |
20220241458 | Removable Film-Forming Gel Compositions Featuring Adhesion Promoters - Film-forming gel compositions, useful in creating conformable and flexible gel bandages, can be formulate from a film-forming polymer, an amine-rich adhesion promoter, and a volatile solvent. The gel compositions form relatively thick films when dried on tissue, and can exhibit enhanced breathability to promote wound healing. In some cases, the film-forming gel composition can include lidocaine. | 2022-08-04 |
20220241459 | AN IMPLANT COMPRISING A COLLAGEN MEMBRANE - The invention is directed to an implantable structure comprising at least one biocompatible backbone scaffold and at least one biocompatible and biodegradable collagen membrane deposited thereon, including methods of its preparation and uses thereof in dental or orthopedic bone regeneration, dura repairs, hernia repairs and similar procedures requiring structural implants. | 2022-08-04 |
20220241460 | METAL SUBSTRATE WITH ANTIBACTERIAL AND OSTEOINTEGRATIVE PROPERTIES FOR IMPLANTOLOGY APPLICATIONS - The present invention relates to a substrate of a metal, preferably titanium or a titanium alloy, having at least one surface coated with an oxide layer of the metal itself, said surface being modified and enriched with Ca, P, Ga, Sr, and, optionally, Ag by anodic spark deposition (ASD). The present invention also relates to a process for producing said substrate by applying the anodic spark deposition (ASD) technique to a substrate, optionally pre-treated, immersed in an electrolytic solution comprising Ca, P, Ga, Sr and, optionally, Ag. Finally, the present invention also relates to a prosthesis and a surgical implant comprising or preferably produced with said substrate, as well as the use thereof for the prevention of bacterial colonisation and promotion of osteointegration in implantology operations, preferably orthopaedic prosthetic implantology. | 2022-08-04 |
20220241461 | BIOIMPLANT WITH EVANESCENT COATING FILM - To provide a bioimplant capable of controlling a rate of an antibacterial agent and an antibiotic to be eluted from the coating film. An evanescent coating film made of a calcium phosphate-based material having crystallinity of 10% to 90% is formed at a predetermined area of the bioimplant and an antibacterial agent or an antibiotic is contained in the coating film to suppress adhesion of bacteria. | 2022-08-04 |
20220241462 | BIOPROSTHETIC TISSUE HAVING A REDUCED PROPENSITY FOR IN VIVO CALCIFICATION - A bioprosthetic tissue having a reduced propensity to calcify in vivo, the bioprosthetic tissue. The bioprosthetic tissue comprises an aldehyde cross-linked and stressed bioprosthetic tissue comprising exposed calcium, phosphate or immunogenic binding sites that have been reacted with a calcification mitigant. The bioprosthetic tissue has a reduced propensity to calcify in vivo as compared to aldehyde cross-linked bioprosthetic tissue that has not been stressed and reacted with the calcification mitigant. | 2022-08-04 |
20220241463 | METHOD FOR PREPARING AN ALLOGRAFT OR XENOGRAFT MATERIAL FROM A CRYSTALLINE LENS CAPSULE - The invention concerns a process for preparing an allograft or xenograft material from a lens capsule, wherein the process comprises the following steps:
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20220241464 | Methods for Development and Use of Minimally Polarized Function Cell Micro-Aggregate Units in Tissue Applications Using LGR4, LGR5 and LGR6 Expressing Epithelial Stem Cells - Provided herein are constructs of micro-aggregate multicellular, minimally polarized grafts containing Leucine-rich repeat-containing G-protein coupled Receptor (LGR) expressing cells for wound therapy applications, tissue engineering, cell therapy applications, regenerative medicine applications, medical/therapeutic applications, tissue healing applications, immune therapy applications, and tissue transplant therapy applications which preferably are associated with a delivery vector/substrate/support/scaffold for direct application. | 2022-08-04 |
20220241465 | THREADS OF CROSS-LINKED HYALURONIC ACID AND HYDROXYAPATITE - Disclosed herein are threads of cross-linked hyaluronic acid and hydroxyapatite, the precursor compositions from which they are prepared and processes for their manufacturing. | 2022-08-04 |
20220241466 | DEGRADABLE POLYMERIC TISSUE SCAFFOLD - The present disclosure relates generally to degradable polymeric scaffolds, methods of making them, and their use in the biomedical field. | 2022-08-04 |
20220241467 | STENT WITH IMMEDIATELY REMOVEABLE COATING - The invention concerns an implantable medical device which is coated with a substance. The invention provides for rapid release of the substance. | 2022-08-04 |
20220241468 | ANTIBACTERIAL ARTICLE COMPRISING A POLYMER MATRIX WITH ALIGNED NANOSCALE FLAKES OR PLATELETS - An article having an antibacterial surface having an antibacterial surface having the nano scale flakes or platelets arranged essentially aligned to each other and extending out from said surface with a length in the range of 0.5-30 microns. The antibacterial surface is produced by processing a mixture of a polymer matrix material and a filler material comprising the nanoscale flakes or platelets by pressing the mixture through a die while heated to a temperature above a melting temperature of the polymer matrix material. Hereby, the nano scale flakes or platelets become aligned, with their longitudinal directions being oriented in substantially the same direction. A surface of the processed mixture which is oriented essentially perpendicularly to the longitudinal directions of the nano scale flakes or platelets is then etched or ablated to partly expose the nano scale flakes or platelets, thereby making the surface antibacterial. | 2022-08-04 |
20220241469 | FAT SCREENING DEVICE - A fat screening device includes a cylinder, and a sieve basket. The cylinder includes a feed inlet, an air outlet, a bottom water outlet, and an accommodating space. The accommodating space is in communication with the feed inlet, the air outlet, and the bottom water outlet. The feed inlet is configured to receive a mixture, the bottom water outlet is disposed at a bottom of the cylinder, the accommodating space is configured to accommodate water and fat resulting from stratification of the mixture, and the bottom water outlet is configured to discharge the water. The sieve basket covers the feed inlet and is arranged separately from the air outlet. The sieve basket is configured to screen the mixture to discharge the water and the fat into the accommodating space. | 2022-08-04 |
20220241470 | FLOW PATH DEVICE AND BIOLOGICAL COMPONENT BAG SYSTEM - A flow path device of a biological component bag system is equipped with a flow path formation member. The flow path formation member includes a first sheet and a second sheet, and flow paths are formed between the first sheet and the second sheet. The flow paths of the flow path formation member include first flow paths and a second flow path. Flow path sealed portions that join the first sheet and the second sheet to each other in a liquid-tight manner are provided on both sides of each of the flow paths within the flow path formation member. | 2022-08-04 |
20220241471 | FLOW PATH DEVICE AND BIOLOGICAL COMPONENT BAG SYSTEM - A flow path device of a biological component bag system is equipped with a device main body. The device main body includes a first sheet and a second sheet, and flow paths are formed between the first sheet and the second sheet. The flow paths include a first flow path, a second flow path, a filter accommodating chamber, and a third flow path. In the device main body, flow path sealed portions that join the first sheet and the second sheet to each other in a liquid-tight manner are disposed along the flow paths. | 2022-08-04 |
20220241472 | RED BLOOD CELL FILTERING APPARATUS AND SYSTEM COMPRISING THE SAME - Provided is a red blood cell filtering apparatus comprising: a filtering film having multiple through holes; and a shell having a first opening on an upper portion of one lateral part of the shell, and a second opening on a lower portion of the other lateral part of the shell; the filtering film is accommodated in the shell. Also provided is a red blood cell filtering system comprising the red blood cell filtering apparatus, a first blood collector and a second blood collector; wherein the first blood collector has a first connecting opening, and the first connecting opening is connected with the first opening through the first connecting apparatus; the second blood collector has a second connecting opening, and the second connecting opening is connected with the second opening through the second connecting apparatus. | 2022-08-04 |
20220241473 | SYSTEM AND METHOD FOR TREATING HAEMORRHAGIC FLUID FOR AUTOTRANSFUSION - A method and system for treating, by filtration, haemorrhagic fluid contained in a container with a view to subsequent autotransfusion, including at least one step of concentrating by filtration said haemorrhagic fluid in order to increase the concentration of red blood cells in the haemorrhagic fluid to reach a target haematocrit level while at the same time removing from the haemorrhagic fluid a filtrate comprising compounds not desired for autotransfusion, further including:
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20220241474 | THORACIC POST-SURGICAL MONITORING AND COMPLICATION PREDICTION - Patient biomarkers may be monitored before, during, and/or after thoracic surgery to predict complications, detect complications, track recovery, and/or make pre-, in- and/or post-surgery recommendations to avoid predicted complications and/or mitigate detected complications. Complications (e.g., prolonged air leak or esophageal stricture) may be predicted based on patient parameters and/or biomarker measurements. Complications may be predicted or detected based on biomarker measurements compared to thresholds associated with a biomarker (e.g., developed from baselines) generated based on patient parameters, pre- and/or in-surgery biomarker measurements, and/or surgical details (e.g., decrease in lung capacity). Recovery milestones may be tracked based on biomarker measurements compared to predicted biomarker measurements for recovery stages. A recommendation (e.g., to avoid a predicted complication and/or mitigate a detected complication) may be a patient-specific selection and/or modification of more of: surgical preparation, in-surgery procedures, surgical instrument selection, surgical and/or post-surgical instrument settings, post-surgery procedures, in-surgery and/or post-surgery monitoring, etc. | 2022-08-04 |
20220241475 | DIALYSIS MACHINE COMPRISING AN APPARATUS FOR IDENTIFYING A DIALYZER AND METHOD OF IDENTIFYING A DIALYZER - The present invention relates to a dialysis machine having a dialyzate circuit and having a dialyzer, wherein the dialysis machine has an apparatus for identifying the dialyzer; wherein the apparatus has means for filling the dialyzer with fluid and has means for determining the filling amount of fluid that is filled into the dialyzer; and wherein the apparatus furthermore has means for determining the pressure that is characteristic for the pressure in the filled region of the dialyzer, wherein an evaluation device is provided that is configured to put the measured filling amount into relationship with the measured pressure and to compare it with a predefined characteristic curve or with a predefined characteristic value, with the evaluation device furthermore being configured to output a signal that depends on whether the relationship determined coincides with the predefined characteristic curve or with the predefined characteristic value. | 2022-08-04 |
20220241476 | TECHNIQUES FOR DETERMINING DIALYSIS PATIENT PROFILES - Methods, apparatuses, and systems for determining patient dialysis profiles, for example, of peritoneal transport status or disease progression, are described. For example, in one embodiment, a method of determining a patient profile of a dialysis patient may include obtaining a volume of fluid associated with the dialysis patient, generating patient information via fluorescence analysis of the patient fluid, and determining the patient profile based on evaluating the patient information with a profile library, the patient profile comprising at least one of a peritoneal transport status classification or a disease progression. Other embodiments are described. | 2022-08-04 |
20220241477 | PORTABLE CONTINUOUS RENAL REPLACEMENT THERAPY SYSTEM AND METHODS - Various embodiments disclosed relate to a portable system for continuous renal replacement therapy. The present disclosure includes a system including a dialyzer, a blood circuit, a dialysate circuit, a cannister, a pump, and a housing. The housing can encase the system, including the dialyzer, circuits, cannister and pump. The system can be transformed between an active transport mode and a stationary mode. In the active transport mode, the components can be within the housing, allowing for patient mobility while attached to the system. | 2022-08-04 |
20220241478 | Medicament Preparation Devices, Methods, and Systems - A system for mixing a batch of medicament has a pump actuator, control valve actuators, a source of concentrate, and a purified water source, all connected by a fluid circuit. A controller controls various control valves to open fluid channels from the source of concentrate and from the purified water source to connect a junction of the fluid circuit to the concentrate container and the purified water source. The controller also controls the pump actuator and a water pump to flow water and concentrate through the junction into a mixing container, such that the mixture of the concentrate and the water requires additional dilution to form a ready-to-use medicament. The controller samples the mixture and calculate an additional quantity of water to add based on the sampling. | 2022-08-04 |
20220241479 | MODULAR ASSEMBLY FOR A PORTABLE HEMODIALYSIS SYSTEM - A modular assembly for a portable hemodialysis system may include a dialysis unit, e.g., that contains suitable components for performing hemodialysis, such as a dialyzer, one or more pumps to circulate blood through the dialyzer, a source of dialysate, and one or more pumps to circulate the dialysate through the dialyzer, and a power unit having a housing that contains suitable components for providing operating power to the pumps of the dialysis unit. The power unit may be selectively connected to the dialysis unit and provide power (e.g., pneumatic power in the form of pressure and/or to vacuum) to the dialysis unit for the pumps when connected to the dialysis unit, but may be incapable of providing power to the dialysis unit when disconnected from the dialysis unit. The dialysis unit and the power unit are sized and weighted to each be carried by hand by a human. | 2022-08-04 |
20220241480 | SOURCE CONTAINER CONNECTOR - A disposable connector for mating a dialysate source container to a dialysis machine comprises a body defining two ports and a collar disposed around one of said ports. The collar of said connector includes a stepped inner surface to seat a seal, a grip ring, and a retaining ring. The seal provides a fluid tight connection with a dialysate source container, whereas the grip ring is embedded in a stem of the dialysate source container so as to mate the connector to the container. The collar also has a series of windows and protrusions interspersed within the windows, which protrusions engage the retaining ring so as to secure the seal, the grip ring and the retaining ring on the stepped inner surface of the collar. | 2022-08-04 |
20220241481 | APPARATUS FOR PROVIDING DIALYSIS CONCENTRATE - The present invention relates to an apparatus for providing liquid dialysis concentrate comprising a dialysis concentrate container for receiving the dialysis concentrate, wherein the dialysis concentrate container has an outflow and wherein the apparatus has a measurement device that is in fluid communication with the outflow and that is configured to determine the density or a property of the dialysis concentrate correlated with the density, with a shut-off element, in particular a valve, being arranged in the outflow by means of which the outflow can be selectively opened or closed. | 2022-08-04 |
20220241482 | DIALYSIS SYSTEM HAVING ADAPTIVE PRESCRIPTION MANAGEMENT - An example peritoneal dialysis system is disclosed. The example peritoneal dialysis system includes at least one pump and a memory device configured to store therapy prescriptions including a low ultrafiltration (“UF”) therapy prescription, a first standard UF therapy prescription with a longer duration and a lower dextrose concentration, and a second standard UF therapy prescription with a shorter duration and a higher dextrose concentration. The memory device also stores a schedule indicative as to which of the therapy prescriptions are to be performed on specified dates. The system further includes a logic implementer configured to determine or identify a current date, use the schedule stored in the memory device to select the therapy prescription based on the current date, and control the at least one pump based on the selected therapy prescription to perform a peritoneal dialysis therapy. | 2022-08-04 |
20220241483 | DIALYSIS MACHINE AND METHOD OF OPERATING A BALANCING CHAMBER SYSTEM OF A DIALYSIS MACHINE - The present invention relates to a dialysis machine having a dialyzer and having a first balancing chamber and having a second balancing chamber of which each has at least two first and second balancing chamber halves separated from one another by a movable wall, wherein each first balancing chamber half is provided with a respective first inflow and with a respective first outflow, wherein the first inflows of the first balancing chamber halves are in fluid communication with a source of fresh dialyzate and the first outflow of the first balancing chamber half is in fluid communication with a dialyzer inflow, and wherein the second inflows of the second balancing chamber halves are in fluid communication with a dialyzer outflow, wherein the second outflows of the second balancing chamber halves are in fluid communication with one another so that consumed dialyzate can be transferred from a second balancing chamber half of one balancing chamber to a second balancing chamber half of the other balancing chamber. | 2022-08-04 |
20220241484 | BLOOD TREATMENT DEVICE COMPRISING ALKALINE PHOSPHATASE - The invention relates to a blood treatment device configured to dephosphorylate extracellular adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and/or lipopolysaccharide (LPS) in the blood of a patient in need thereof in an extracorporeal blood circuit, wherein the device comprises a matrix having alkaline phosphatase (AP) immobilized thereon. The invention further relates to an extracorporeal blood circuit comprising a blood treatment device of the invention and to the blood treatment device for use as a medicament or to methods of treating an infection, preferably a blood or systemic infection, such as sepsis, and/or for the treatment of sepsis-associated acute kidney injury (AKI). | 2022-08-04 |
20220241485 | SUCTION BOTTLE FOR THROMBUS ASPIRATOR AND THROMBUS ASPIRATOR - An objective of the present invention is to a suction bottle or a thrombus aspirator having a novel structure capable of solving at least one of the problems inherent in conventional suction bottles such as allowing a practitioner to quickly and easily confirm the presence of a thrombus in the suctioned blood, being able to easily separate the suctioned blood and thrombus, and being able to make the bottle compact to facilitate handling. The suction bottle ( | 2022-08-04 |
20220241486 | REDUCED PRESSURE THERAPY APPARATUSES AND METHODS OF USING SAME - Some embodiments comprise a pump assembly for reduced pressure wound therapy, comprising a housing, a flow pathway through the pump, one or more valves in communication with the flow pathway, a pump supported within or by the housing, and a one-way flow valve in fluid communication with the pump. The pump assembly can have a pressure sensor in communication with the flow pathway through the pump, and at least one switch or button supported by the housing, the at least one switch or button being accessible to a user and being in communication with the controller. The one-way flow valve can be configured to substantially prevent a flow of gas through the one-way flow valve in a direction of flow away from the pump. The pump assembly can have a controller supported within or by the housing, the controller being configured to control an operation of the pump. The pump has been sterilized following the assembly of the pump such that an inside and an outside of the housing, the flow pathway, the one or more valves, the pump, the controller, the battery compartment, and the at least one switch or button have been sterilized. | 2022-08-04 |
20220241487 | PROGRESSING ASPIRATION PUMP IN A SURGICAL SYSTEM - An apparatus, system and method for providing a surgical handpiece. The apparatus, system and method may include: a proximal segment and a distal segment. The distal segment may include: an emulsifying tip; an irrigation output in fluidic communication with the irrigation input, and capable of supplying irrigating fluid to a surgical site; and a progressing cavity pump aspirator in fluidic communication with an aspiration port and capable of aspirating the emulsified material to the material collection point through the aspiration connection. The pump may include: a stator; and a rotor rotationally associated with the stator to effectuate pumping, via the stator cavities, of the emulsified material from the aspiration port in the distal segment through the proximal section. | 2022-08-04 |
20220241488 | COLLAPSIBLE STRUCTURE AND METHOD OF USE - A collapsible, clamping and/or steerable apparatus in conjunction with negative pressure system and methods for using such an apparatus are described. Preferred embodiments of the invention have lengths and bent and/or increase their curvatures along their lengths, by preferentially contracting and transforming upon negative pressure. | 2022-08-04 |
20220241489 | NEGATIVE PRESSURE DEVICE FOR ARTICULATING JOINT - A negative pressure device includes a drape covering a dressing site on a patient, a sealing element connected with the drape, a flexible gas chamber housing disposed outwardly from the drape with respect to the enclosed chamber, and a reactor. The drape is made from a thin sheet film and is capable of maintaining a negative pressure underneath the drape. The sealing element and the drape are configured so that the sealing element cooperates with the drape to define an enclosed volume covered by the drape and surrounded by the sealing element when applied to skin. The flexible gas chamber housing defines a flexible gas chamber. The reactor is positioned with respect to the enclosed volume and the flexible gas chamber to consume a gas found in air within the enclosed volume and the flexible gas chamber. | 2022-08-04 |
20220241490 | IRRIGATED CATHETER SYSTEM INCLUDING FLUID DEGASSING APPARATUS AND METHODS OF USING SAME - Disclosed herein is an irrigated catheter system. The system includes a catheter shaft including a fluid delivery tube, an electrode coupled to the catheter shaft at a distal end thereof and in fluid communication with the fluid delivery tube, a fluid source coupled in fluid communication with the fluid delivery tube for supplying fluid thereto, and a fluid degassing apparatus fluidly coupled between the fluid source and the fluid delivery tube such that the fluid flows through the fluid degassing apparatus. The fluid degassing apparatus includes one of a gas filter including a permeable membrane disposed in a fluid-tight housing, a centrifugal separator, and a multi-chamber system including a vacuum chamber and a fluid reservoir fluidly coupled downstream of the vacuum chamber. | 2022-08-04 |
20220241491 | ENEMA DEVICE, AND A DELIVERY CONTAINER FOR USE IN SAID ENEMA DEVICE - The present invention relates to an enema device comprising a delivery container arranged for accommodating an enema and an applicator nozzle for dispersing the enema, and wherein the delivery container is arranged as a hand held pump and for remaining in an at least partly compressed configuration when the user releases the pressure on said delivery container during use. Thereby is provided a simple, inexpensive and essentially maintenance free enema device which can be used for self-administrating of an enema. | 2022-08-04 |
20220241492 | CONNECTED INFUSION PUMP DEVICE - An infusion pump device comprises a pump unit having an inlet and an outlet, a connector being in fluid communication with the inlet of said pump unit, a medication reservoir accommodation portion for accommodating a medication reservoir having a label or tag so that an outlet of the medication reservoir is to be coupled to said connector, and a reader which is provided at said medication reservoir accommodation portion so that the reader is adapted to read a label or tag of the medication reservoir when arranged at said medication reservoir accommodation portion. | 2022-08-04 |
20220241493 | CRADLE FOR A MEDICAL DEVICE - Disclosed herein is a cradle for a medical device. The cradle has an inner cradle side and an opposing outer cradle side, wherein the outer cradle side is adapted for attachment to a patient's skin with at least part of the outer cradle side facing the patient's skin. The medical device has a medical device coupler, wherein the medical device coupler is adapted for coupling the medical device to the cradle such that part of the medical device is facing the inner cradle side. The cradle further includes a drain fluidly coupling the inner cradle side with the outer cradle side. | 2022-08-04 |
20220241494 | MICROINFUSER WITH AUTOMATIC NEEDLE RETRACTION - A device for delivering a fluid includes a housing defining an interior space and having a bottom surface configured for contacting a patient. The bottom surface defines a needle opening. The device also includes a reservoir disposed within the interior space of the housing for containing a fluid therein, a needle carrier disposed within the housing, and an injection needle supported by the needle carrier and defining a lumen. The lumen of the injection needle is configured to be placed in fluid communication with the reservoir. The injection needle is transitionable from an initial position in which the injection needle is disposed within the housing, to a use position in which the injection needle extends through the needle opening, and a substantially shielded position in which the injection needle is disposed within the housing and the lumen of the needle is blocked by a portion of the housing. | 2022-08-04 |
20220241495 | Method for Determining Syringe Parameters by a Syringe Pump, and Apparatuses - The present disclosure relates to a method for determining syringe parameters. It encompasses, as a first step, the providing of a medical syringe pump with a syringe receptacle having a syringe inserted herein, a drive unit for a slide, a counting device for counting motor steps, at least one sensor, a control device and a storage device. The method as described herein also encompasses, as further steps, moving the slide successively at different positions corresponding to known nominal volumes of the syringe. In a further step, the difference between these two positions is determined and, finally, optionally a number of motor steps of the drive unit of the syringe pump is calculated per nominal volume unit with respect to the inserted syringe. | 2022-08-04 |
20220241496 | MEDICAL INFUSION PUMP, METHOD OF CONTROLLING MEDICAL INFUSION PUMP, AND MEDICAL INFUSION PUMP SYSTEM - A medical infusion pump includes: a reader configured to read identification information stored in an RF tag by wireless communication; and a control unit configured to set information about administration of a drug based on the identification information read from the RF tag. In a case in which the reader reads two different pieces of the identification information, the control unit selects only one piece of the identification information out of the two different pieces of the identification information and sets the information about administration based on said one piece of the identification information. | 2022-08-04 |
20220241497 | ASSEMBLY FOR A CARTRIDGE NEEDLE INSERTION MECHANISM - An assembly for a cartridge needle insertion mechanism includes a housing, a cartridge needle defining a cartridge needle axis and a cartridge closed by a septum. A cartridge needle slider is linearly guided by the housing along an insertion axis to be moved by a driver from a first position, where the cartridge needle is not penetrating the septum, to a second position where the cartridge needle penetrates the septum of the cartridge. A cartridge needle holder holding the cartridge needle is operatively coupled with the cartridge needle slider to be moved with the cartridge needle slider from the first to the second position. The assembly includes a compliant coupling between the cartridge needle holder and the cartridge needle slider configured to facilitate movement of the cartridge needle holder with respect to the slider when moved into the second position, thereby compensating for needle penetration forces. | 2022-08-04 |
20220241498 | TEST METHOD DEVELOPMENT FOR MASS FLOW IDENTIFICATION OF OCCLUDING SMALL PARTICULATES IN MICROLUMENS - Method and systems for determining acceptance criteria for identification of occluding particles in a lumen of a device are provided. The methods and systems can be used in methods of identifying an occluded device in an inspection method. | 2022-08-04 |
20220241499 | PERISTALTIC INFUSION PUMP TUBE SEGMENT AND INFUSION PUMP DEVICE WITH SUCH A TUBE SEGMENT - A peristaltic infusion pump tube segment comprises a first tube portion having a surrounding wall adapted for an upstream occlusion detection, a second tube portion downstream of said first tube portion and adapted to be temporally engaged by an engagement structure, wherein said second tube portion comprises a surrounding wall being at least partly thicker than the wall of said first tube portion and made of an elastic material which allows said second tube portion to be essentially reformed at those portions which are currently not subject to the engagement by the engagement structure, a third tube portion downstream of said second tube portion and having a surrounding wall adapted for an air in line detection, and a fourth tube portion adapted for a downstream pressure detection. The peristaltic infusion pump tube segment is provided in an infusion pump device which comprises a pump mechanism configured as a peristaltic mechanism. | 2022-08-04 |
20220241500 | GLUCOSE LEVEL MANAGEMENT WITHOUT CARBOHYDRATE COUNTING - Disclosed herein are techniques related to glucose level management without carbohydrate counting. The techniques may involve obtaining contextual information for a meal, predicting amounts of glucose to be absorbed into a bloodstream of the patient over a duration of time due to consumption of the meal based on the contextual information for the meal, determining one or more amounts of insulin to counteract effects of the predicted amounts of glucose, and affecting insulin therapy based on outputting information indicative of the determined one or more amounts of insulin. | 2022-08-04 |
20220241501 | DOSAGE RECOMMENDATION FACILITATED BY ARTIFICIAL INTELLIGENCE - Disclosed herein are techniques related to glucose level management without carbohydrate counting. The techniques may involve obtaining contextual information for a meal, predicting amounts of glucose to be absorbed into a bloodstream of the patient over a duration of time due to consumption of the meal based on the contextual information for the meal, determining one or more amounts of insulin to counteract effects of the predicted amounts of glucose, and affecting insulin therapy based on outputting information indicative of the determined one or more amounts of insulin. | 2022-08-04 |
20220241502 | DETECTION OF AUDIBLE ALERTS - A medical device may determine an occurrence of an alert condition. The medical device may transmit, to a separate device, data indicative of the occurrence of the alert condition. After transmitting the data indicative of the occurrence of the alert condition to the separate device, the medical device may determine, based on an audio signal generated by a microphone of the medical device, that the separate device has outputted an audible alert. The audio signal may correspond to audio captured by the microphone. | 2022-08-04 |
20220241503 | TECHNIQUES AND DEVICES THAT ADAPT BASAL PROFILES FOR DRUG DELIVERY APPLICATIONS - The disclosed examples provide techniques and devices for determining a daily basal profile or an adjusted basal need for a drug based on a collection of data that is filtered and processed. A controller may be configured to evaluate a history of drug delivery in both basal and bolus dosages and generate a daily basal profile or an adjusted basal need that is a time dependent that may be used to schedule basal dosages of a drug that more closely addresses a user's drug needs over the course of a time period, such as a day, week or the like. | 2022-08-04 |
20220241504 | SYSTEMS AND METHODS FOR INCORPORATING CO-FORMULATIONS OF INSULIN IN AN AUTOMATIC INSULIN DELIVERY SYSTEM - Disclosed herein are systems and methods for the delivery of a co-formulation of insulin and a second drug, such as GLP-1, using an automated insulin delivery system. In a first embodiment, a dose of insulin is calculated by a medication delivery algorithm and a reduction factor is applied to account for the effect of second drug on the user's daily insulin requirement. In a second embodiment of the invention, a total amount of the second drug administered to the user during the past 24 hours is used to modify the correction factor and the insulin-to-carbohydrate ratio used by the medication delivery algorithm to cause a reduction in the insulin delivered to the user to account for the effect of the administration of the second drug portion of the co-formulation. | 2022-08-04 |
20220241505 | ASSEMBLY FOR A DRUG DELIVERY DEVICE AND DRUG DELIVERY DEVICE - An assembly for a drug delivery device is provided, the assembly comprising: a housing for receiving a reservoir, and a cap releasable with respect to the housing, wherein the assembly has a capped state and an uncapped state, wherein the cap comprises a member to be gripped by a user for releasing the cap from the housing, wherein the member is rotatable to release the cap from the housing, wherein the assembly comprises an interface to convert rotational movement of the member into axial movement of the member, the interface comprising a track configured to guide movement of the member, wherein the track has a first region and a second region, wherein, when the first region guides the movement, the member is displaced from the housing by a first distance, and when the second region guides the movement, the member is displaced from the housing by a second distance. | 2022-08-04 |
20220241506 | DRIVE ASSEMBLY FOR A MEDICAMENT DELIVERY DEVICE - A power pack for use with a medicament delivery device is presented having a plunger rod movable along a longitudinal axis; a drive spring operably connected to said plunger rod; a plunger rod sleeve arranged with holding elements for releasably holding said plunger rod with said drive spring in a tensioned state. Signal initiating elements are arranged to said plunger rod; and signal generating elements arranged to cooperate with said signal initiating elements for providing information to a user of a medicament delivery device about the movement of said plunger rod when said plunger rod sleeve has been activated to release said holding elements. | 2022-08-04 |
20220241507 | Autoinjector - Described is an autoinjector comprising a case, a door hingedly coupled to the case and having an open position and a closed position, a plunger slidably disposed in the case, and at least one drive spring applying a biasing force on the plunger relative to the case, wherein the door is operably coupled to the plunger, and wherein rotation of the door from the closed position to the open position moves the plunger from a distal position in the case to a proximal position in the case and compresses the at least one drive spring. | 2022-08-04 |
20220241508 | MEDICAL HOLLOW ARTICLE, MEDICAL HOLLOW ARTICLE HAVING A CLOSURE CAP, METHOD FOR PRODUCING A MEDICAL HOLLOW ARTICLE, AND KIT - The invention relates to a medical hollow container ( | 2022-08-04 |
20220241509 | CRACK RESISTANT MEMBER - A crack resistant member including a member body, a first region that is a hollow space provided in the member body to open to a surface of the member body and is configured to dispose a driving part that outputs a pressing force in an extension direction of the space, and a coupling portion that is configured to mechanically couple to the driving part and is formed on an inner wall surface of the first region, in which at least the coupling portion is formed from a resin material having a flexural modulus of 2600 MPa or greater as measured in accordance with ISO 178. | 2022-08-04 |
20220241510 | Medical Syringe with a Thermostat - The invention relates to a medical syringe device with thermostat, for a medical instrument, to insert a needle into a. patient's body to a determined insertion depth. The safety medical syringe device, comprises a hub, a needle, a protecting shield, longitudinal resilient means, transverse resilient means, a housing, and is provided with different technical means configured to cooperate with each other in order to perform different functions of the device. The proposed device enables to control the temperature of the device, wherein the device is a disposable one and it ensures its user an injection as per medical requirements. | 2022-08-04 |
20220241511 | Injection Device - An injection device for administering a dose of a liquid medicament includes an elongated housing having a dispensing end and being configured to accommodate a cartridge filled with the liquid medicament, a drive mechanism configured to operably engage with the cartridge for expelling of a dose of the medicament from the cartridge via the dispensing end, a protective cap releasably attachable to the housing to cover the dispensing end, a first electronic circuit attached to the protective cap and electrically connected to at least a first cap electrode arranged on the protective cap, and a second electronic circuit arranged inside the housing, coupled to the drive mechanism and electrically connected to at least a first housing electrode that is located on the housing. | 2022-08-04 |
20220241512 | Apparatus for Detecting a Dose of Medicament Delivered from an Injection Device - Disclosed is an apparatus for detecting a dose delivered from an injection device having a dose setting mechanism that allows different dosages to be delivered. The accessory has an attachment portion configured to attach the accessory to the injection device, and a body that houses an optical sensor arrangement of the injection device includes a cartridge assembly and a housing, the housing contains a dose dispensing mechanism and a dose setting mechanism, the dose dispensing mechanism includes a part that moves in response to movement of the dose setting mechanism and indicates a dose dialed by the dose setting mechanism. The housing further includes a window aligned with the part of the dose dispensing mechanism to allow the optical sensor arrangement to detect a location of the part that moves in response to movement of the dose setting mechanism to determine the dose dialed by the dose setting mechanism. | 2022-08-04 |
20220241513 | Injection Device with a Filling Level Indicator - The present disclosure relates to an injection device for setting and injecting of a dose of a medicament. The injection device includes an elongated housing extending along a longitudinal direction and configured to accommodate a cartridge, a first member movably arranged inside the elongated housing for setting of the dose, and a second member, and a piston rod configured to advance in a longitudinal distal direction and operable to exert a distally directed pressure onto a bung of the cartridge for expelling of the dose. Depending on the setting, the first member is rotatable relative to the second member or is rotationally locked to the second member. The injection device includes a filling level indicator threadedly engaged with one of the first member and the second member, the filling level indicator being rotationally locked and longitudinally slidingly engaged with the other one of the first member and the second member. | 2022-08-04 |
20220241514 | Supplemental Device for Attachment to an Injection Device - A supplemental device for attachment to an injection device, the supplemental device having a housing containing at least two electromechanical switches each having an open state and a closed state and a protrusion associated with each switch configured to protrude from the housing so as to contact a rotatable surface of the injection device while the supplemental device is attached to the injection device; and a processor arrangement configured to detect a change in the state of each of the switches; and to determine a direction of rotation of the rotatable surface of the injection device from the detected state changes. | 2022-08-04 |
20220241515 | PLUNGER CAPABLE OF MOVING BACK AND FORTH AND MEDICINE INJECTION DEVICE INCLUDING SAME - The present invention relates to a plunger capable of moving back and forth and a medicine injection device including same, in which, by manually or automatically moving the plunger backwards, user convenience may be provided. In addition, according to the present invention, when a rotation unit ( | 2022-08-04 |
20220241516 | PEN NEEDLE - A pen needle ( | 2022-08-04 |
20220241517 | Needle and Syringe System with Automatic Safety Shield that Renders a Needle Safe - A safety syringe system that automatically shields a needle after an injection. A plunger extends into a barrel. An elastic return construct is provided that has at least one stretchable arm. The elastic return construct engages the barrel and positions each stretchable arm along the exterior of the barrel. A safety shield is provided that slides over a first end of the barrel. In a first position, the needle is protected by the safety shield. In a second position, the needle is exposed. The safety shield engages and stretches the elastic return construct when moved from the first position to the second position. A locking mechanism is used to lock the safety shield into its second position. The locking mechanism is released by elements displaced by movement of the plunger. | 2022-08-04 |
20220241518 | ADMINISTRATION ASSEMBLY FOR A MEDICAMENT DELIVERY DEVICE AND A MEDICAMENT DELIVERY DEVICE COMPRISING THE SAME - An administration assembly for a medicament delivery device is presented having a plunger rod, a plunger rod holder and an activation sleeve configured to receive a portion of the plunger rod holder. The triggering member is configured to move the activation sleeve from a first position to a second position relative to the plunger rod holder. The plunger rod is configured to be axially locked relative to the plunger rod holder when the activation sleeve is in the first position. The plunger rod is released from being axially locked when the activation sleeve is moved towards the second position. | 2022-08-04 |
20220241519 | DEVICE AND METHOD FOR DELIVERING A MEDICAMENT - A device for delivery of medicament is presented that has an elongated housing, a container mounted within the housing and adapted to contain liquid medicament, a stopper slidably arranged within said container, and a delivery mechanism comprising a resilient member, a plunger assembly having one end connected to the stopper and a second end being operably connected to the resilient member, a rotatable latch for releasably retaining the plunger assembly in a first position where the resilient member has an accumulated energy, where rotation of the latch releases the plunger assembly such that the accumulated energy is transferred to the plunger assembly for driving the stopper within the container whereby the medicament within said container is delivered to an injection site. After delivery of the medicament a rotator having a hard stop feature aligns with a rib on the protective shield to prevent retraction of the protective shield. | 2022-08-04 |
20220241520 | TAMPER-EVIDENT CLOSURE - The disclosed tamper-evident closure ( | 2022-08-04 |
20220241521 | DEVICE FOR FIBRIN-BIOPOLYMER-FORMING SUBSTANCE APPLICATION - The two devices described allow for greater control over application of a fibrin biopolymer and yet remain simple enough to be used by both medical personnel and by non-medical workers. One of the devices includes chambers where components necessary for formation of a fibrin biopolymer are stored and are pushed by plungers connected to an actuator upon the actuator receiving pressure from the user, with the components mixing in a chamber within the device and flowing out of a tube connected to the mixing chamber before formation of the fibrin biopolymer is completed. The other device dispenses formulations that include components necessary for formations of a fibrin biopolymer onto a skin of a patient using one or more propellants, with the formation of the fibrin biopolymer being initiated after the formulations are dispensed on the patient's skin and are intentionally mixed together. | 2022-08-04 |
20220241522 | SYSTEM AND METHOD FOR DELIVERY OF GAS TO A TISSUE - A system for delivery of gas to a tissue, comprises: a first container containing the gas, an applicator having a distal end arranged to deliver the gas to the tissue, a second container containing a purging gas, and; and a flow control system for controlling flow of gas. The system also comprises a three-port valve having a first port for receiving the gas from the first container, a second port for receiving the purging gas from the second container, and a third port in fluid communication with the applicator. The valve is switchable between a first state at which the first port fluidly connects to the third port, and a second state at which the second port fluidly connects to the third port. | 2022-08-04 |
20220241523 | FLOW REGULATING INHALER DEVICE - An inhaler device for pulmonary delivery of at least one substance from a drug dose cartridge to an inhaling user, including: a first conduit for conducting a carrier airflow to a proximal opening of a mouthpiece for use by the user; a holder configured to position the dose cartridge within the carrier airflow; and a second conduit for conducting a shunting airflow to the mouthpiece without passing through the dose cartridge position. In some embodiments, a controller connected to a valve controls a rate of carrier airflow, for example by controlling the shunting airflow, based on a sensor indication of airflow rate and a target airflow profile. | 2022-08-04 |
20220241524 | AEROSOL FORMULATION, CANISTER, AND INHALER CONTAINING THE FORMULATION, AND METHOD OF USE - A pressurized canister coated with poly(fluoroalkylene) polymer or a copolymer of poly(fluoralkylenes) and containing a formulation comprising one or more active pharmaceutical ingredients, PVP, and a propellant, as well as methods of using the same. | 2022-08-04 |
20220241525 | METHOD FOR CONTROLLING FLUID JET PLUME CHARACTERISTICS - A pharmaceutical drug delivery device and method of using the pharmaceutical drug delivery device. The pharmaceutical drug delivery device includes a cartridge body; a fluid outlet nozzle attached to the cartridge body; and a fluid jet ejection cartridge disposed in the cartridge body, wherein the cartridge contains a liquid pharmaceutical drug and a fluid ejection head containing a plurality of fluid ejection nozzles and associated fluid ejectors. A processor disposed on a logic board or fluid ejection head is provided for executing a control algorithm to control the ejection head to modify plume characteristics of fluid ejected from the ejection head by controlling one or more of fluid jet firing frequency, burst length, and fluid jet firing burst delay. | 2022-08-04 |
20220241526 | METHOD FOR CONTROLLING FLUID JET PLUME CHARACTERISTICS - A drug delivery device and method of using the device. The device includes a cartridge body; a fluid outlet nozzle attached to the cartridge body; and a cartridge disposed in the cartridge body. A fluid ejection head is attached to the cartridge and is in fluid flow communication with the fluid outlet nozzle. The cartridge contains a liquid pharmaceutical drug. A logic board is disposed in cartridge body and is electrically connected to the ejection head on the ejection cartridge. A processor is disposed on the logic board or on the fluid ejection head for executing a control algorithm to control the ejection head to modify plume characteristics of fluid ejected from the ejection head by controlling one or more operating parameters selected from (a) a number of fluid ejectors fired per ejection burst, (b) a position of fluid ejectors fired per ejection burst, and (c) both (a) and (b). | 2022-08-04 |
20220241527 | VENTILATOR SYSTEMS AND METHODS - A ventilator includes a ventilation drive configured to drive ventilation gas from a gas source to a patient and a patient interface section configured to guide inspiratory gas from the ventilation drive to a patient connection, receive expiratory gas from the patient connection, and expel the expiratory gas out of the ventilator. The ventilation drive and patient interface section are configured to removably connect to at least one host comprising a ventilation path portion so as to divert the inspiratory gas through the ventilation path portion of the host when connected thereto. | 2022-08-04 |
20220241528 | VENTILATOR SYSTEMS AND METHODS - A portable ventilator includes a ventilation drive configured to drive ventilation gas from a gas source to a patient, wherein the portable ventilator is configured to removably connect to a host such that when the portable ventilator is connected to the host the ventilation drive drives ventilation gas from a host gas source to the patient and when the portable ventilator is not connected to the host the ventilation drive drives ventilation gas from a portable gas source to the patient. | 2022-08-04 |