32nd week of 2022 patent applcation highlights part 40 |
Patent application number | Title | Published |
20220252501 | MAGNETICALLY COUPLED COLLECTING SYSTEM FOR FLOW CYTOMETRY AND CELL SORTER SYSTEMS - A collecting system with a magnetically coupled sample mover is provided for flow cytometry and cell sorter systems. The collecting system uses magnets in a driver carriage to control the position of other magnets in a follower carriage. The driver carriage can thereby control the position of the follower carriage without physically touching the follower carriage. | 2022-08-11 |
20220252502 | Integrated Biocontainment Cell Sorter - Disclosed is an integrated biocontainment cell sorter that isolates portions of the cell sorter that can create contamination. Two containment systems are utilized. A main cabinet containment system contains input samples. An aerosol management containment area includes a nozzle chamber with a nozzle and a sort chamber with sort plates and collection media that collect a droplet stream from the nozzle. The main cabinet is maintained at a first low pressure and clean air is recirculated under a positive pressure. The aerosol management containment area is kept at a second low pressure, which is lower than the first pressure, so that contamination does not leak from the aerosol management containment area into the main cabinet containment area. A sliding sash window is located over an access opening in the main cabinet and can be moved to access different portions of the main cabinet without changing the substantially constant first low pressure in the main cabinet. | 2022-08-11 |
20220252503 | SYSTEMS AND METHODS FOR SAMPLE USE MAXIMIZATION - The present invention provides systems, devices, and methods for point-of-care and/or distributed testing services. The methods and devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device can be modified to allow for more flexible and robust use with the disclosed methods for a variety of medical, laboratory, and other applications. The systems, devices, and methods of the present invention can allow for effective use of samples by improved sample preparation and analysis. | 2022-08-11 |
20220252504 | A MATERIAL UNIFORMITY DETECTION DEVICE AND DETECTION METHOD - The present invention belongs to the technical field of new energy detection, in particular to a material uniformity detection device and method. The purpose of the present invention is to provide a material uniformity detection device which can meet the requirement of detection of diversified materials such as biomass slurry aiming at the problem of difficulty in quantifying uniformity state of the biomass slurry. The sample pool is driven by the rotating lifting device for lifting and spiral motion, data collection is performed on the sample pool in the form of a certain path, and an image is established for the relationship between a large number of light intensity values of transmission light and heights measured for multiple times to respectively display the uniformity of horizontal layering and uniformity in the vertical direction, to judge the overall uniformity of the material samples. | 2022-08-11 |
20220252505 | METHOD OF CORRECTING FOR AN AMPLITUDE CHANGE IN A SPECTROMETER - A method of correcting for an amplitude change in a spectrometric instrument output includes: exposing a sample in a sample holder to electromagnetic radiation at a plurality of wavenumbers; detecting electromagnetic absorption intensities in the sample at the plurality of wavenumbers; providing to a computer device the detected electromagnetic absorption intensities indexed against wavenumber as spectral data; applying in the computer device a mathematical transform (Icorr) to the spectral data to correct for an amplitude change in the spectrometric instrument's output and calculated by determining a difference (Δ(SBZ)/) between first derivatives of a logarithmic transformation of spectral data (SB | 2022-08-11 |
20220252506 | A Wirelessly Powered Frequency-Swept Spectroscopy Sensor - Systems and methods in accordance with embodiments of the invention implement wirelessly powered frequency-swept spectroscopy sensors. One embodiment includes a first antenna configured to receive an incoming signal; an energy-harvesting circuit configured to produce DC energy; a power management unit; an on-chip signal source configured to use the incoming signal as a locking signal; and a second antenna configured to transmit back a signal locked to the frequency of the incoming signal. In a further embodiment, the wirelessly powered frequency-swept spectroscopy sensor includes a third antenna, where the third antenna is on-chip. | 2022-08-11 |
20220252507 | SUBSTRATE PROCESSING APPARATUS, SUBSTRATE INSPECTING METHOD, AND STORAGE MEDIUM - A substrate processing apparatus includes: a holding unit configured to hold a substrate having a film formed on a surface; an imaging unit configured to acquire image data by imaging the surface of the substrate held by the holding unit; a spectroscopic measuring unit configured to acquire spectroscopic data by dispersing light from the surface of the substrate held by the holding unit; and a control unit configured to control the holding unit, the imaging unit, and the spectroscopic measuring unit. | 2022-08-11 |
20220252508 | LIGHT EMITTING APPARATUS, LIGHT EMITTING METHOD, SPECTROMETER AND SPECTRUM DETECTION METHOD - A light emitting apparatus has a plurality of light emitting units, and each of them emits a light with a light emission peak wavelength and a wavelength range. The wavelength ranges of the two light emitting units with the two adjacent light emission peak wavelengths are partially overlapped or non-overlapped. Each of the light emitting units discontinuously emits a light with a lighting frequency. The present disclosure further provides the spectrometer, a light emitting method and a spectrum detection method, and all of them utilizes the light emitting apparatus, a background noise is discarded and a frequency domain signal of an optical spectrum signal of a tested object is reserved, so as to have a filtering effect and achieve high test accuracy, which can replace conventional spectrometer for wavelength resolution characteristics. | 2022-08-11 |
20220252509 | MEASURING DEVICE AND METHOD FOR DETERMINING A SUBSTANCE CONCENTRATION - A measuring device for determining a substance concentration of a fluid arranged in a measurement volume includes a source emitting a source spectrum, a wavelength-selective means arranged before the measurement volume, a measurement space limiting the measurement volume at least in a beam path, and a detector for measuring a wavelength-related absorption of a measurement spectrum having passes through the measurement volume. A fluorescence-reducing element is arranged in the beam path between the detector and the measurement volume. A beam splitter is arranged between the source and the measurement volume. | 2022-08-11 |
20220252510 | POWDERY-MATERIAL MEASUREMENT DEVICE AND METHOD OF CHECKING OR CALIBRATING PROPERTIES OF SENSOR PROBE - A powdery-material measurement device includes a sensor probe configured to receive reflected light from mixed-powdery materials passing adjacent thereto or transmitted light through the mixed-powdery materials to measure characteristics of the mixed-powdery materials while the powdery-material measurement device is in operation to deliver the mixed-powdery materials toward an equipment, and a standard sample having known characteristics and facing the sensor probe that is disposed to receive the reflected light from the standard sample or the transmitted light through the standard sample, when the mixed-powdery materials are not present adjacent the sensor probe while the powdery-material measurement device is in operation to deliver the mixed-powdery materials toward the equipment. | 2022-08-11 |
20220252511 | COMPOSITION ANALYZER AND COMPOSITION ANALYSIS SYSTEM - A composition analyzer has an accommodating device, an optical detection device, a driving device and a support part. The accommodating device accommodates an object to be analyzed, and has an accommodating space, a transparent plate and a rotating part, wherein the transparent plate is disposed on one of two opposite sides of the accommodating space, the rotating part is disposed on the accommodating device. The optical detection device has a solid state light source emitter and a light receiver, wherein another one of the two opposite side of the accommodating space is disposed with one of another one transparent plate, a light reflection plate and a non-transparent plate. The driving device is connected to the rotating part. The support part is pivotally connected to the rotating part. The accommodating device rotates in the YZ plane, which can perform uniform and repeated measurements to analyze content of grains. | 2022-08-11 |
20220252512 | THREE-DIMENSIONAL IMAGING WITH ENHANCED RESOLUTION - An imaging system may include an imaging metrology tool with an illumination source, one or more illumination optics to direct illumination from the illumination source to a sample, a detector, one or more collection optics to image the sample onto the detector; and one or more aberration-controlling components. The one or more aberration-controlling components may provide aberration correction for imaging the sample onto the detector according to one or more degrees of freedom, where the one or more degrees of freedom include at least a defocus of the imaging system, and where the one or more aberration-controlling components are integrated with at least one of the one or more illumination optics, the one or more collection optics, or the detector. | 2022-08-11 |
20220252513 | Filter Device for an Optical Module for a Lab-on-a-Chip Analysis Device, Optical Module for a Lab-on-a-Chip Analysis Device and Method for Operating an Optical Module for a Lab-on-a-Chip Analysis Device - A filter device for an optical module for a lab-on-a-chip analysis device, in which the optical module has a light path, includes a support element, a filter support, and a drive device. The support element can be mounted in the optical module. The filter support is arranged so that it can move on the support element. The filter support also has a first filter region and a second filter region. The drive device is configured such that the filter support can move between a first position in which the first filter region is arranged in the light path, and a second position in which the second filter region is arranged in the light path. | 2022-08-11 |
20220252514 | FLUORESCENT SOLID-STATE MATERIALS FOR OPTICAL CALIBRATION AND METHODS THEREOF - A method for calibrating scientific instrumentation or light utilizing instrumentation utilizing one or more small-molecule, ionic isolation lattice (“SMILES”) composites for use as calibration targets for a scientific instrument, such as a fluorescent microscope. The SMILES composite can include a dye element, a couterion element, and a receptor element. In some exemplary embodiments, the SMILES composite can include the following formula: a (dye | 2022-08-11 |
20220252515 | METHOD FOR DETECTION OF BACTERIA IN FAECES - A method of detecting fluorescence from bacteria suitable for determining the presence of faeces or other fluorophores, the method comprising the steps of: illuminating a target with fluorescence excitation light having an excitation wavelength and monitoring for the emission of fluorescence light from the target at wavelengths longer than the excitation wavelength. | 2022-08-11 |
20220252516 | SPECTROSCOPIC APPARATUS AND METHODS FOR DETERMINING COMPONENTS PRESENT IN A SAMPLE - A method of determining components present in a sample from spectral data obtained from the sample including resolving each of a plurality of models of the spectral data, the plurality of models including models having a different number of component reference spectra selected from a set of predetermined component reference spectra; selecting a one of the plurality of models based upon a model selection criterion and determining one or more components present in the sample based upon the selected model. The model selection criterion includes a measure for each model, which balances improvements in fit quality of the model to the spectral data against a complexity penalty determined from the number of component reference spectrum used in the model. | 2022-08-11 |
20220252517 | EMISSION-BASED DETECTOR FOR CAPILLARY GAS CHROMATOGRAPHY - An emission-based detector for use in conjunction with capillary chromatography or other applications involving a gas sample having a small volume is provided. The detector is based on optical emission from a plasma medium. An optical cartridge or other detection and/or processing means may be provided to receive and analyse the emitted radiation and thereby obtain information on the gas to be analysed. The emission-based detector includes a gas inlet, a gas outlet and a capillary channel which is in fluid communication with the gas inlet and gas outlet. The capillary channel acts as the plasma chamber. Preferably, the capillary channel has transversal dimensions of the same order as the cross-section of typical chromatography capillary columns and defines a winding path within the detection area. A multi-cell emission-based detector and a method of analysing a gas sample using multiple detection cells are also provided. | 2022-08-11 |
20220252518 | ELECTRONIC TEST RESULT DETERMINATION AND CONFIRMATION - A technology is described for a system for identifying a colorimetric test result from a pathogen test performed on a solid phase substrate. The system can comprise a sensor configured to detect a spectrum of color wavelengths. The system can comprise one or more processors. The one or more processors can be configured to: receive color wavelength data; determine a wavelength threshold for providing a pathogen positive test result; identify whether the color wavelength data meets or exceeds the wavelength threshold for providing a pathogen positive test result; and generate a result indicator indicating either a pathogen positive or pathogen negative test result. | 2022-08-11 |
20220252519 | MICROFLUIDIC DEVICE COMPRISING A MICRODROP HAVING A SOL-GEL MATRIX - A microfluidic device that includes at least one capillary trap and at least one microdrop having a sol-gel matrix. The microdrop is trapped in the capillary trap. | 2022-08-11 |
20220252520 | FLUORESCENCE IMAGING OF GEMSTONE ON TRANSPARENT STAGE - Systems and methods here may be used for a setup of fluorescence image capturing of a gemstone, such as a diamond placed on a flat stage. Some examples utilize a setup that both sends light and captures the image from the table side of the gemstone by passing ultraviolet (UV) light between 10 nm and 400 nm to the gemstone and capturing the excited fluorescence image for analysis through a dichroic beam splitter. In some examples, the cutoff is 300 nm. The dichroic beam splitter arrangement allows for the camera to focus on the same interface of the stage and gemstone over and over for ease of use and without moving, changing, or adjusting the equipment for different samples. | 2022-08-11 |
20220252521 | INSPECTION APPARATUS FOR DISPLAY MODULE - An inspection apparatus for a display module includes a seat part in which a first recess part including a bottom surface and a side surface extending from the bottom surface is defined, and an inspection part including an inspection connector. The seat part includes a support part having a certain stiffness and located on the bottom surface and a variable part connecting the support part and the side surface. The variable part has a certain elasticity or a portion of the variable part penetrates into the side surface. | 2022-08-11 |
20220252522 | Method for minimizing and eliminating sheetrock sanding using an illuminating device - A method to minimize applying joint compound and sanding by illuminating an area of the gypsum board to show anomalies thereon includes a step of providing a plurality of wireless lighting devices operable by a common remote controller, a step of removably attaching these devices in a spaced-apart arrangement and using the remote controller to energize all lighting devices to identify remaining anomalies. All lighting devices are turned off once the next coat of joint compound is applied and then turned on after it dries to illuminate the remaining surface anomalies. Operation of lighting devices is accomplished without removing or repositioning thereof to assure consistency of illumination over the entire work period. | 2022-08-11 |
20220252523 | REFLECTED ENERGY DETECTION SYSTEM AND METHOD FOR DETECTING OILY RESIDUE IN TWO-PHASE IMMERSION COOLING SYSTEMS - A system for detecting residue in a two-phase immersion cooling system based on changes in the intensity of energy reflected off a reflective surface. An energy source is positioned at an incident angle relative to a reflective surface and an intensity sensor is positioned at a target reflected energy angle relative to the reflective surface, wherein the intensity sensor detects light or other energy reflected off the reflective surface. If residues are deposited on the reflective surface, the reflectivity of the residue will change the reflected energy angle or otherwise change the amount of energy reflected toward the sensor. A heating element may generate more heat than existing components such that the system detects the presence of residues with sufficient time to allow less expensive and less intensive corrective measures. | 2022-08-11 |
20220252524 | INSPECTION DEVICE - An inspection device is such that the inspection device executes a mounting inspection of a component using an inspection image of a board on which the component is mounted and includes an imaging device and an image processing device. The imaging device obtains three monochromatic images of the board in R, G, B. The image processing device sets a board color using brightness values of the three monochromatic images obtained by the imaging device, calculates complementary colors of the board color so set, determines on a color component having a largest brightness value in individual color components of the complementary colors so calculated, and sets the monochromatic image having the color component so determined in the obtained three monochromatic images as the inspection image. | 2022-08-11 |
20220252525 | Inspection Apparatus Adjustment System and Inspection Apparatus Adjustment Method - The present invention addresses the problem of quickly specifying an optical condition of a wafer to be inspected, and in particular, accelerating optical condition setting after obtaining a customer wafer. An inspection apparatus automatic adjustment system according to the present invention comprises: an analysis condition setting interface | 2022-08-11 |
20220252526 | INSPECTION SYSTEM - An inspection system ( | 2022-08-11 |
20220252527 | Deriving evidence for an indeterminate artifact or natural object in an encompassing medium using multi-node differential event analysis. - This invention is an apparatus for the detection of indeterminate objects of interest contained within an encompassing medium using event detection including but not limited to radiation event counts. Methods currently in use for this purpose rely on prior knowledge of the object's characteristics (size, age, orientation, etc.), as in the case of detecting possible nuclear devices being transported by a vehicle. Additionally, these methods rely on the use of heavy lead shielding to eliminate the effects of background and atmospheric radiation, which makes the apparatus difficult to move and limits the size of the measurable area. Such methods are highly impractical for use in field studies, where the specific characteristics of objects of interest are often unknown and difficult terrain makes the use of heavy, unwieldy equipment impossible. | 2022-08-11 |
20220252528 | X-RAY CT APPARATUS - The present invention provides an X-ray CT apparatus capable of obtaining a high-quality X-ray CT image by suppressing occurrence of an artifact. The X-ray CT apparatus including an X-ray imaging system including an X-ray irradiation unit and an X-ray detector, a rotating stage disposed between the X-ray irradiation unit and the X-ray detector, a rotation mechanism configured to relatively rotate the X-ray imaging system and the rotating stage about a rotation axis orthogonal to an optical axis of an X-ray that runs from the X-ray irradiation unit to the X-ray detector, and a load mechanism which is set on the stage and applies test force to a test piece includes an angle changing mechanism that tilts a bending tester to change the direction of the test force applied to the test piece by the bending tester from a direction orthogonal to the optical axis of the X-ray. | 2022-08-11 |
20220252529 | THERMALLY GUIDED CHEMICAL ETCHING OF A SUBSTRATE AND REAL-TIME MONITORING THEREOF - A method of controlling a substrate etching process includes disposing a bottom surface or a top surface of a substrate adjacent to volume of etching fluid to produce an etchant-substrate interface and heating the etchant-substrate interface via spatially controlled electromagnetic radiation. The method also includes transmitting a monitoring beam through the substrate, the substrate and volume of etching fluid being at least partially transparent at the wavelength range of the monitoring beam and measuring a property of the substrate surface during the substrate etching process via the monitoring beam to produce a real-time measured property for the substrate. A corresponding etching system and computer-program product is also disclosed herein. | 2022-08-11 |
20220252530 | SYSTEM AND METHOD FOR PREDICTING THE PRESENCE OF RARE EARTH ELEMENTS - A system for predicting rare earth elements (REEs) in a feedstock sample includes a measurement instrument that records a measurement for a sample, a processor communicatively coupled to the measuring instrument, and a memory communicatively coupled to the processor and containing machine readable instructions that, when executed by the processor, cause the processor to correlate the measurement series using a model; and predict a presence of one or more rare earth element based at least in part on the correlation. A method for predicting rare earth elements includes measuring feedstock samples via XRF or PGNAA, to generate a measurements of elements of interest with a lower atomic weight than REEs; correlating the measurements with a model; and predicting a presence of one or more rare earth elements based at least in part on the correlation. | 2022-08-11 |
20220252531 | INFORMATION PROCESSING APPARATUS AND CONTROL METHOD FOR INFORMATION PROCESSING APPARATUS - An information processing apparatus includes information acquisition means configured to acquire quantitative information on a test substance, which is estimated by inputting spectrum information of a sample including the test substance into a learning model, and degree-of-contribution acquisition means configured to acquire a degree of contribution of the acquired quantitative information on the test substance. | 2022-08-11 |
20220252532 | THERMAL CONDUCTIVITY OF VISCOELASTIC MATERIALS - Assessing a thermal conductivity of a viscoelastic material in a steady state using a conduction method includes i) allowing a sample of the viscoelastic material to reach thermal equilibrium in a liquid at a first temperature, ii) assessing a heat flow of the sample at the first temperature, iii) repeating i) and ii) at one or more additional temperatures, and iv) assessing the thermal conductivity of the viscoelastic material based on the heat flow of the sample at the first temperature and the one or more additional temperatures, a cross-sectional area of the sample, and a temperature-thickness gradient of the sample at thermal equilibrium. | 2022-08-11 |
20220252533 | SAMPLE HOLDER, SYSTEM, AND METHOD FOR ANALYZING ENERGETIC MATERIALS - A sample holder for a system for analyzing energetic materials, including a first holder element having a first heating element, the heating element embodied as a resistance heater and having at least one first sample region provided for accommodating a sample. A second holder element having a second heating element, the heating element embodied as a resistance heater and having at least one second sample region provided for being brought into contact with a sample. A device for connecting the holder elements so as to enclose a sample between the first sample region and the second sample region. | 2022-08-11 |
20220252534 | METHOD OF FORMING A SENSOR DEVICE - The disclosed subject matter relates generally to methods of forming a semiconductor device, such as a moisture sensor. More particularly, the present disclosure relates to a method of forming a sensor device and a bond pad in the same dielectric region. The present disclosure also relates to the semiconductor devices formed by the method disclosed herein. | 2022-08-11 |
20220252535 | HUMIDITY INITIATED GAS (HIG) SENSORS FOR VOLATILE ORGANIC COMPOUNDS SENSING - Volatile organic compounds (VOCs) can be sensed using humidity-initiated gas (HIG) sensors. | 2022-08-11 |
20220252536 | FLUIDIC IMPEDANCE PLATFORM FOR IN-SITU DETECTION AND QUANTIFICATION OF PFAS IN GROUNDWATER - Materials for binding per- and polyfluoroalkyl substances (PFAS) are disclosed. A fluidic device comprising the materials for detection and quantification of PFAS in a sample is disclosed. The fluidic device may be configured for multiplexed analyses. Also disclosed are methods for sorbing and remediating PFAS in a sample. The sample may be groundwater containing, or suspected of containing, one or more PFAS. | 2022-08-11 |
20220252537 | NEW POLYMER MATRIX ELECTRODES - Electrochemical probes (or sensors), resistant to corrosive agents present in seawaters or in industrial waters, useful for detecting compounds present in water, are here described, wherein said probes comprise at least one polymer matrix electrode, in which said electrode is selected from the group comprising counter electrode, reference electrode and working electrode. | 2022-08-11 |
20220252538 | PORTABLE DEVICES AND METHODS FOR DETECTING AND IDENTIFYING COMPOUNDS IN A FLUID SAMPLE - This disclosure relates to portable devices for detecting various biomarker compounds, such as antibodies, antigens, nucleic acids (DNA and RNA), fusion proteins, genes, etc. in a clinical specimen such as saliva or blood for the detection of diseases, viruses, and other common pathogens. Also disclosed herein is the detection and identification of one or more diseases using a portable device comprising an electrochemical CRISPR/Cas based biosensor system. | 2022-08-11 |
20220252539 | BIOSENSOR ACTIVATION AND CONDITIONING METHOD AND SYSTEM - A method of detecting a target biological entity in a biofluid using a sensor, wherein the biofluid comprises a plurality of the target biological entities and nanoparticles, the sensor comprising a substrate bearing a pair of electrodes having an affinity with the nanoparticles, and wherein a region between the electrodes defines a sensing region. The method comprises: treating the biofluid with a suspension comprising a plurality of nanoparticles to obtain a treated mixture comprising bound nanoparticle-entity assemblies; introducing the treated mixture to the sensor; conditioning the sensor in the presence of the treated mixture by applying an activation voltage between the electrodes to increase a degree of connection between a surface of the pair of electrodes and at least one bound nanoparticle-entity assembly in contact with the surface of the pair of electrodes; and detecting the presence of target biological entities by using the pair of electrodes to detect a current through the at least one bound nanoparticle-entity assembly. | 2022-08-11 |
20220252540 | SENSOR ELEMENT - A sensor element comprises an element body and a porous protective layer covering a surface of the element body. In this sensor element, the porous protective layer comprises a first layer exposed on a surface of the sensor element and a second layer disposed between the element body and the first layer. The first layer contains ceramic particles and anisotropic ceramics having an aspect ratio of 5 or more and 100 or less, and a part of the first layer is in contact with the element body. Further, a porosity of the second layer is 95 vol % or more. | 2022-08-11 |
20220252541 | In Situ Treatment of Chemical Sensors - Systems and methods for a treatment of chemical sensors placed in a wellbore. A method may comprise providing a chemical sensor disposed in a sensing chamber, wherein the chemical sensor is on an optical fiber installed in a wellbore; optically interrogating the chemical sensor with the optical fiber; and pumping a treatment fluid through a fluid supply line and into the sensing chamber. | 2022-08-11 |
20220252542 | SINGLE MOLECULE NANOPARTICLE NANOWIRE FOR MOLECULAR ELECTRONIC SENSING - The disclosed embodiments relate to nanotechnology and to nano-electronics and molecular electronic sensors. In an exemplary embodiment, a nano-sensor having a nanoparticle complex attached at each end to a respective nano-electrode. An exemplary nanoparticle complex includes a biomolecule coupled at each end to a metallic nanoparticle to form a dumbbell-shaped molecular bridge. A method to manufacture single molecule dumbbell nanowires for forming conductive molecular bridges includes the steps of: providing a double-stranded nucleic acid with terminal 3′ thiol modification on both the strands conjugated to a gold (Au) nanoparticle (AuNP) on each end; purifying single biomolecule dumbbells from aggregates using size-exclusion chromatography; imaging the eluted products by electron microscopy to validate formation of single molecule dumbbells; trapping a single molecule dumbbell between a pair of nanoelectrodes on a substrate, the electrodes separated by a nanogap; and measuring the conductivity of a trapped single molecule dumbbell. | 2022-08-11 |
20220252543 | BIOSENSOR - A biosensor system includes an array of biosensors with a plurality of electrodes situated proximate the biosensor. A controller is configured to selectively energize the plurality of electrodes to generate a DEP force to selectively position a test sample relative to the array of biosensors. | 2022-08-11 |
20220252544 | FINE PARTICLE MEASURING SYSTEM - A nanopore device includes a pore and an electrode pair. A current measurement unit applies a bias voltage that corresponds to a voltage setting command across an electrode pair and generates digital current data that corresponds to a current signal that flows through the nanopore device. A data processing apparatus generates the voltage setting command, acquires the current data and voltage data including information with respect to the waveform of the bias voltage Vb in a form in which they are associated on the time axis, and judges the kind of particles stored in the nanopore device based on the current data and the voltage data. | 2022-08-11 |
20220252545 | METHODS AND SYSTEMS FOR DETECTING AEROSOL PARTICLES WITHOUT USING COMPLEX ORGANIC MALDI MATRICES - Disclosed are systems are methods for identifying the composition of single aerosol particles, particularly that of bioaerosol particles, without pre-treatment using complex organic MALDI matrices. A continuous timing laser may be used to index aerosol particles, measure particle properties, and trigger a pulse ionization laser. Ionized fragments and optionally photons associated with each particle producing by the ionization laser may be analyzed using one or more detectors including a TOF-MS detector and an optical detector. The laser pulse may comprise a simultaneous IR and UV laser pulse when fragments comprise predominantly of UV chromophores. Unique spectral data associated with each indexed particle from each detector may be compiled using data fusion to generate compiled spectral data. Machine learning methods may be used to improve the prediction of composition over time. | 2022-08-11 |
20220252546 | SYSTEM AND METHOD FOR MEASURMENT OF MAGNETIC NANOPARTICLES - Embodiments of the present invention relate to a system and method for performing temperature-dependent measurements of a magnetic nanoparticle sample. The system includes high frequency coils and sample temperature tunable assembly to determine the specific relaxation process for magnetic nanoparticle sample using both time and frequency domain techniques. During the temperature-dependent measurements of a magnetic nanoparticle sample, system in accordance with embodiments of the present invention resolve the nanoparticle dynamics using a temperature-tunable dual mode, AC susceptibility and magnetic relaxometry, to cover a broad range of frequencies and time scales. Other operational modes of the invention can drive the nanoparticles with arbitrary waveforms (sinusoidal, sum of sinusoids, or repeated pulses) to elicit and measure tailored response behavior from the magnetic nanoparticle sample. | 2022-08-11 |
20220252547 | ULTRASOUND INSPECTION TECHNIQUES FOR DETECTING A FLAW IN A TEST OBJECT - Transmit-Receive Longitudinal (TRL) probes can be used for the inspection of noisy material, such as austenitic materials. By using various techniques, an inspection area is not constrained by a wedge design of an ultrasonic probe and the benefits of using a linear probe array (rather than a matrix) are maintained. Volumetric or TFM-like imaging on austenitic materials using a linear transmit array and a linear receive array that are out of plane with one another (a TRL configuration) and not in the main imaging place can simplify the inspection and analysis of such materials. For each scan position, an ultrasound probe can acquire acoustic imaging data. Then, a processor can then combine acquisitions from adjacent scan positions to create an imaging result using synthetic aperture focusing technique (SAFT) principles to recreate a focalization in a passive axis of the probe. | 2022-08-11 |
20220252548 | CHAMBER COMPONENT CLEANLINESS MEASUREMENT SYSTEM - An apparatus for measuring contaminants on a surface of a component is provided. An extraction vessel for holding a measurement fluid has an opening adapted to form a meniscus using the measurement fluid. An actuator moves at least one of the extraction vessel and the component to a position where the meniscus is in contact with the surface of the component. A transducer is positioned to provide acoustic energy to the measurement fluid. | 2022-08-11 |
20220252549 | SYSTEM AND METHOD FOR MORE EFFICIENT ULTRASONIC INSPECTION OF JET-ENGINE DISKS - An inspection system comprising a first and second computer controlled robotic arm that each have five degrees of freedom (x, y, z, α, β) and respectively control position and tilt of first and second probes for inspection of a workpiece, wherein the computer control ensures that the two robotic arms simultaneously scan the probes over the workpiece, without interfering with each other. | 2022-08-11 |
20220252550 | Ultrasound Acoustic Field Manipulation Techniques - Two methods for rendering haptic surfaces through spatial modulation of ultrasound are described: Singular Value Decomposition (SVD) with Tikhonov Regularization and Mini-Batch, Stochastic Gradient Descent with Momentum (MSGDM). Further, adjustment in the placement of transducers, arrays can be generated which allow for variable focus points using a limited set of driving signals. This is accomplished by generating a set of mutually-exclusive transducer placement layouts which when driven together produce a set of sufficiently orthogonal fields at various points of interest. Further, using basic transformations on sampling locations a field can be translated or rotated in 3-dimensional space. This enables the creation of spatiotemporal modulated haptics with reduced computation. Further, mid-air haptics using ultrasound can be generated via amplitude modulation or via spatial modulation of control points defined at spatial locations in an acoustic field above a phased array device. | 2022-08-11 |
20220252551 | MATERIAL PROFILING FOR IMPROVED SIZING ACCURACY - A material profile can be determined by assuming an elliptical or circular arc geometry and by using acoustic noise generated by diffuse internal reflection and/or specular reflection on the internal (ID) or external (OD) interface of the material under inspection, such as a pipe or curved plate. A non-destructive testing (NDT) technique can acquire acoustic data of the material using an ultrasonic signal. The acquired acoustic data can be filtered such that the acoustic noise generated by diffuse internal reflection and/or specular reflection is separated from any flaws in the material. Positions of the acoustic noise can be determined and then a regression technique can be applied to the positions, which can generate an equation of a circle, for example, such as to provide a radius and thickness of the pipe or curved plate. | 2022-08-11 |
20220252552 | GAS CHROMATOGRAPH-MASS SPECTROMETER - A gas chromatograph-mass spectrometer includes a gas chromatograph having a column that separates a sample into components, a mass spectrometer provided in a vacuum housing, and an interface that introduces a sample that has been separated into components in the gas chromatograph into the mass spectrometer, and the interface includes a partition wall fixed to the vacuum housing to close an opening formed in the vacuum housing, a line pipe that is fixed to the partition wall to penetrate the partition wall, includes a sample outlet line of the column and introduces the sample into the mass spectrometer, a heater that heats the line pipe in an axial direction, and a fixer that fixes the heater being in contact with the partition wall. | 2022-08-11 |
20220252553 | ENCAPSULATED PRE-ANALYTIC WORKFLOWS FOR FLOW-THROUGH DEVICES, LIQUID CHROMATOGRAPHY AND MASS SPECTROMETRIC ANALYSIS - This invention relates to encapsulated reagents for sample and workflow preparation prior to chromatographic, spectroscopic or other analytical systems, use thereof, and devices comprising the same. | 2022-08-11 |
20220252554 | THERMAL DESORPTION TUBE COLLECTION SYSTEM AND METHOD - A thermal desorption tube collection system uses a thermoelectric cooler to collect and concentrate gas samples. In some modes, the operation of the cooler is reversed to flow the concentrated sample directly into a separator such as a gas chromatography system. Components resolved in time by a thermal desorption separator accumulate in a sample cell and are analyzed by electromagnetic radiation-based spectroscopic techniques. Also presented are methods for analyzing biogas samples. | 2022-08-11 |
20220252555 | LIQUID SENDING SYSTEM FOR LIQUID CHROMATOGRAPH - A liquid sending system includes a plurality of liquid sending pumps that operate independently from one another and send a mobile phase into a common flow path, a pressure sensor for detecting a liquid sending pressure in the flow path, and a liquid sending failure detector configured to detect a liquid sending failure caused by any of the plurality of liquid sending pumps by periodically acquiring a liquid sending pressure detected by the pressure sensor and detecting a fluctuation of the liquid sending pressure associated with a driving period of each of the plurality of liquid sending pumps. | 2022-08-11 |
20220252556 | BINARY PUMP AND LIQUID CHROMATOGRAPH - A binary pump in which an operation controller causes each of two liquid delivery pumps to execute, while a secondary discharge process is executed, a suction process, a first pre-pressurizing process, and a standby process. The operation controller causes each of the two liquid delivery pumps to execute a second pre-pressurizing process before proceeding from the secondary discharge process to the primary discharge process. Furthermore, the operation controller causes, as long as continuous liquid delivery by each of the two liquid delivery pumps is not interrupted, at least one of the two liquid delivery pumps to execute avoidance operation of interrupting the standby process and proceeding to the second pre-pressurizing process by using the operation state of each of the two liquid delivery pumps, so as to avoid overlap of execution time zones of the primary discharge processes of the two liquid delivery pumps. | 2022-08-11 |
20220252557 | SUPERCRITICAL FLUID CHROMATOGRAPH AND SAMPLE SUPPLY METHOD USED IN SUPERCRITICAL FLUID CHROMATOGRAPH - A supercritical fluid chromatograph includes a suction discharger that sucks and discharges a sample, a first sample loop connected to the suction discharger through a first flow path, a first flow path switcher that is connected to the first sample loop through a second flow path, a sample container connected to the second flow path through a third flow path when the first flow path switcher is in a first switch state, and a second flow path switcher connected to the second flow path through a fourth flow path when the first flow path switcher is in a second switch state. The fourth flow path is connected to a second sample loop when the second flow path switcher is in a third switch state, and the second sample loop is connected to an analysis flow path to which a solvent is supplied as a supercritical fluid when the second flow path switcher is in a fourth switch state. | 2022-08-11 |
20220252558 | SYSTEM AND METHOD FOR CONTROLLING FLUID FLOW WITHIN A LIQUID CHROMATOGRAPHY SYSTEM - The present disclosure relates to methodologies, systems, and apparatus for controlling fluid flow within a chromatography system. The chromatography system includes a mobile phase pump configured to pump a liquid mobile phase through a column and a restrictor positioned downstream of the column and upstream of a detector. The system also includes a valve configured to operate in at least two positions. In a first position, the valve is configured to direct the output of the column to bypass the valve and reach the detector, while in the second position the valve directs the output of the column to waste. | 2022-08-11 |
20220252559 | TWO-DIMENSIONAL LC-MS/MS SYSTEMS - The present invention relates to a novel analytical method for detecting one or more analytes in a source sample by continuous flow 2D LC-MS/MS using a single LC system. | 2022-08-11 |
20220252560 | MOBILE PHASE TEMPERATURE CONTROL DEVICE FOR SUPERCRITICAL FLUID APPARATUS AND SUPERCRITICAL FLUID APPARATUS - A mobile phase temperature control device for a supercritical fluid apparatus is used in a supercritical fluid apparatus including a separation column, and includes a cartridge heater, a flow path portion and a first temperature sensor. The cartridge heater has a rod shape. The flow path portion is wound around the cartridge heater, and a mobile phase is guided to the separation column of the supercritical fluid apparatus by the flow path portion. The mobile phase is put in a supercritical state at least in the separation column. The first temperature sensor is attached to the flow path portion, and the temperature of the flow path portion is detected by the first temperature sensor. | 2022-08-11 |
20220252561 | Chromatography Apparatus and Method - The present invention relates to a computer implemented method ( | 2022-08-11 |
20220252562 | MONITORING SYSTEM AND MONITORING METHOD - A system for monitoring the alkalinity of a treatment liquid in a treatment tank includes a reaction tank; an indicator burette which drops an indicator into the reaction tank; a reagent burette which drops an acidic reagent into the reaction tank; a probe-type absorptiometer to be inserted into the reaction tank; a measuring device which analyzes the transmittance of a solution detected by the absorptiometer to calculate the alkalinity; a first system that collects the treatment liquid from the treatment tank for storing and supplies the treatment liquid to the reaction tank; a control device which controls the operation of the first system so as to supply the treatment liquid to the reaction tank, outputs a completion signal to the measuring device, and controls a discharge system so as to discharge the treatment liquid in the reaction tank, when the calculation of alkalinity by the measuring device is completed. | 2022-08-11 |
20220252563 | METHOD FOR CALIBRATING AT LEAST ONE SENSOR BY USE OF AT LEAST ONE CALIBRATION SENSOR - A method for calibrating at least one sensor by use of at least one calibration sensor, the method comprising: obtaining information indicative of a proximity time period when the at least one sensor and the at least one calibration sensor are in a predefined proximity zone of each other for a time period which is sufficient for calibration; obtaining information about a refractory time period for at least one of the at least one sensor and the at least one calibration sensor; calibrating the at least one sensor by a sensor reading of the at least one sensor and a sensor reading of the at least one calibration sensor, which sensor readings are taken when they are in the predefined proximity zone, wherein the refractory time period for the at least one of the at least one sensor and the at least one calibration sensor is considered by delaying its sensor reading such that it is ensured that the sensor readings of the at least one sensor and the at least one calibration sensor are spatially and temporally aligned for the calibration. | 2022-08-11 |
20220252564 | DETECTION SYSTEM FOR AN ELECTRONIC NOSE ALLOWING A PHYSICOCHEMICAL CLASSIFICATION OF ODOURS AND ELECTRONIC NOSE COMPRISING SUCH A SYSTEM - A detection system for an electronic nose which allows a physicochemical classification of odors, that is to say a classification as a function of the physicochemical properties of the volatile compounds, or odorous molecules, making up these odors. This detection system comprises sensors with cross-reactivity with respect to volatile compounds, each sensor comprising a sensitive part functionalized by a receptor comprising a sequence formed by the repetition of an α-amino acid. The α-amino acid of the receptor of a sensor of a first series of sensors is hydrophilic, while the α-amino acid of the receptor of another sensor of the first series is hydrophobic, and the α-amino acids of the receptors of two sensors of a second series of sensors have isoelectric points which differ from one another by at least one pH unit. | 2022-08-11 |
20220252565 | ELECTRONIC DEVICE - A device includes an upper metallic layer, a lower layer, and a memory array positioned between the upper and lower layers, wherein the memory electrical characteristic changes when storing data. | 2022-08-11 |
20220252566 | REAL-TIME ODOR TRACKING SYSTEM USING VEHICULAR ODOR MEASURING DEVICE - Provided according to one embodiment of the present disclosure is a real-time odor tracking system using a vehicular odor measuring device, the system comprising: a vehicular odor measuring device which measures odor information while traveling on the ground; and a server which analyzes and manages information on odor generated from a specific point, on the basis of the odor information collected from the vehicular odor measuring device. | 2022-08-11 |
20220252567 | ADAPTIVE SENSOR FILTERING - Environmental conditions affecting a sensor having a thermal coefficient are compensated by applying an adaptive filter to an environmental condition reference signal. The resulting adaptive cancellation signal may be used to provide feedback control to a first heating element. | 2022-08-11 |
20220252568 | MEANS AND METHODS FOR SCORING VEGETABLES AND FRUITS - Configurable application, for scoring an object including: configuration interface to: receive configuration parameters for each object including: a. a list of attributes to be associated with an object; b. a maximum total score; c. for each attribute in the attributes list: minimum value, maximum value, and weight; and d. configuration type; and a processing unit to calculate scoring for the object according to the received configuration parameters, by: receiving a value for each attribute in the object's attributes list; comparing each attribute value against a predefined minimum and maximum; calculating total score according to a predefined formula, when the attribute value is within the range of the minimum and maximum; calculating total score based on configuration type, when the attribute value is outside the minimum and maximum range; displaying the total score to a user via a display unit. The calculating is performed only when all attributes have values. | 2022-08-11 |
20220252569 | ANALYSIS METHOD OF 3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE ACTIVE PHARMACEUTICAL INGREDIENT, TREATMENT FOR AMYOTROPHIC LATERAL SCLEROSIS, INHIBITION OF PROGRESSION OF AMYOTROPHIC LATERAL SCLEROSIS, AND METHOD OF PRODUCING MEDICAMENT CONTAINING 3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE ACTIVE PHARMACEUTICAL INGREDIENT - A method of analyzing phenylhydrazine content in a 3-methyl-1-phenyl-2-pyrazolin-5-one active pharmaceutical ingredient includes obtaining a first measured value by measuring a phenylhydrazine content of a standard solution including phenylhydrazine or a salt thereof, a first acidic water and a first water-soluble organic solvent and having a phenylhydrazine concentration of 0.01 μg/mL to 10 μg/mL, obtaining a second measured value by measuring a phenylhydrazine content in a sample solution including a 3-methyl-1-phenyl-2-pyrazolin-5-one active pharmaceutical ingredient, a second acidic water and a second water-soluble organic solvent, and detecting a phenylhydrazine content in a 3-methyl-1-phenyl-2-pyrazolin-5-one active pharmaceutical ingredient based on the first measured value and second measured value. The first acidic water is hydrochloric acid, and/or an aqueous acetic acid solution, the first water-soluble organic solvent is acetonitrile and/or methanol, the second acidic water is hydrochloric acid, and/or an aqueous acetic acid solution, and the second water-soluble organic solvent is acetonitrile and/or methanol. | 2022-08-11 |
20220252570 | TOTAL ORGANIC CARBON SENSOR - The present invention relates to a sensor ( | 2022-08-11 |
20220252571 | SYSTEMS AND METHODS FOR ASPHALT DENSITY AND SOIL MOISTURE MEASUREMENTS USING GROUND PENETRATING RADAR - Systems and methods for ground penetrating radar for determining thickness, density and moisture are therefore provided. According to an embodiment, a ground penetrating radar (GPR) system comprises a system controller configured to produce an electromagnetic signal for signal penetration of a pavement material. Further, the GPR system comprises a frequency modulated continuous wave controller. Further, the GPR system comprises an ultra wide band (UWB) antenna coupled to the system controller, wherein the UWB antenna is configured to transmit the produced electromagnetic signal to the pavement material and receive the electromagnetic signal as a reflection from the pavement material. Further, the system controller is further configured to receive the electromagnetic signal from the UWB antenna. | 2022-08-11 |
20220252572 | METHODS AND COMPOSITIONS FOR ASSEMBLY OF BIOLOGICAL NANOPORES - Methods and compositions for the manufacture and use of a detection apparatus based on one or more native biological nanopores are provided. Uses include, but are not limited to, detection and sequencing of nucleic acids. | 2022-08-11 |
20220252573 | METHOD AND DEVICES FOR DETECTING VIRUSES AND BACTERIAL PATHOGENS - The embodiments disclose a method including functionalizing a biosensor with a biologic analytical target prior to installation into a detection cartridge, depositing a test subject bodily fluid test sample onto the biosensor surface, inserting the detection cartridge into a portable detection cartridge reader, measuring the electrical impedance of the bodily fluid test sample across biosensor energized electrodes, providing algorithms for analyzing measured electrical impedance data of the bodily fluid test sample obtained in the detection cartridge, identifying and determining the presence of biologic analytical target molecules in the bodily fluid test sample, and transmitting results of the test results to the test subject. | 2022-08-11 |
20220252574 | IMMUNOMODULATORY COMPOSITIONS AND METHODS OF USING - Immunomodulatory compositions that include at least one alphavirus capsid protein and methods of using such immunomodulatory compositions. In one aspect, methods of immunomodulating IL-1/TLR signaling in a cell are provided. Such methods typically include contacting the cell with an alphavirus capsid protein or a portion thereof, thereby immunomodulating IL-1/TLR signaling in the cell. | 2022-08-11 |
20220252575 | SCREENING METHOD AND TOXICITY EVALUATION METHOD - A method for screening for a therapeutic drug for a disease involving excessive activation of a complement, using a s cytotoxicity marker associated with the complement as an index, including (1a) a step of adding a complement to a cell produced from a stem cell to cause the cell to form a cytotoxicity marker associated with the complement, and (2a) a step of adding a therapeutic drug candidate, and selecting a substance that decreases the amount of the cytotoxicity marker is provided by the present invention. | 2022-08-11 |
20220252576 | Assay - The present invention relates to methods for assessing the pluripotent state of a stem cell culture by determining the presence of marker proteins, related kits and uses. | 2022-08-11 |
20220252577 | Mobile Device Multi-Analyte Testing Analyzer for Use in Medical Diagnostic Monitoring and Screening - A mobile device based multi-analyte testing analyzer for use in medical diagnostic monitoring and screening, and a method of manufacturing the same are disclosed. A reflectance based, colorimetric test strip reader for use with a mobile device having a jack plug receiving socket, said test strip reader adapted for removably receiving a test strip having a test strip longitudinal axis, comprising a housing; a jack plug operably coupled to and extending from said housing and adapted for operable coupling with said jack plug receiving socket; a test strip adapter including structure defining a test strip receiving channel; a light source oriented within said housing for directing light toward said test strip receiving channel to illuminate a test strip arranged within said test strip adapter; and a light sensor oriented within said housing to sense light reflected from a test strip carried by said test strip receiving channel. | 2022-08-11 |
20220252578 | TANGENT FLOW HEMOLYSIS DETECTION BLOOD TESTING DEVICE - A tangent flow hemolysis blood testing assembly, device and method are described herein. The presently disclosed and claimed inventive concept(s) relate to a device(s), kit(s), and method(s) for injecting a patient's liquid test sample into a reaction vessel. More specifically, the presently disclosed and claimed inventive concept(s) relate to an improved liquid test sample injection device that comprises a plug that forms an airtight seal that facilitates the active injection of a liquid test sample into a reaction vessel, and kits and methods of use related thereto. | 2022-08-11 |
20220252579 | CHEMILUMINESCENCE IMMUNOASSAY ANALYZER - The present invention discloses a chemiluminescence immunoassay analyzer, including a rotating disc assembly for carrying and thermal insulation of capillary tubes, an air-blowing assembly for removing residual liquid from the capillary tubes, a detection assembly for detecting the number of luminescent photons in the capillary tubes, and a bottom plate for installing the rotating disc assembly, the air-blowing assembly, and the detection assembly. The present invention further includes a charging and recycling system and a sample feeding assembly, wherein the charging and recycling system includes a fixed seat, a capillary tube push-out device, a storage device, a first driving device, and a waste liquid recycling device; the capillary tube push-out device is used for pushing capillary tubes out of the storage device and squeezing out reagents stored in the storage device; the storage device is used for storing the reagents and providing the coated capillary tubes. | 2022-08-11 |
20220252580 | REVERSIBLE CELL DETECTION WITH CONJUGATES HAVING A LINKER FOR INCREASED FLUORESCENT BRIGHTNESS AND AN ENZYMMATICALLY RELEASABLE FLUORESCENT MOIETY - The invention is directed to a conjugate for labelling a target moiety on a cell, characterized with the general formula (I) (X | 2022-08-11 |
20220252581 | LATERAL FLOW ASSAY FOR DETECTION OF MONENSIN - Methods are provided for detecting the presence of monensin in animal feed using a competitive lateral flow assay. The methods allow for qualitative detection of monensin, as well as quantitative detection at a very high level of sensitivity, e.g., detection of 10 ppm or less in a feed sample. Competitive lateral flow assay strip devices are also provided for use in the methods. | 2022-08-11 |
20220252582 | CHO HOST CELL PROTEIN ASSAY - The present invention provides compositions, kits, and methods for the detection of host cell proteins (HCPs) in biological samples. In some embodiments, the present invention utilizes immunization of ayes hosts with proteins derived from non-ayes host cells to produce ayes antibodies specific for non-ayes HCPs. | 2022-08-11 |
20220252583 | SEMICONDUCTOR BASED BIOSENSOR UTILIZING THE FIELD EFFECT OF A NOVEL COMPLEX COMPRISING A CHARGED NANOPARTICLE - The present invention relates to a biosensor for detecting analytes comprising a bio-sensing surface which comprises a field effect transistor and a first binding molecule which is bonded to the surface of the field effect transistor. Furthermore, the biosensor comprises a complex comprising second binding molecules which are conjugated to charged nanoparticles by linker molecules, wherein at least one second binding molecule conjugated to a charged nanoparticle interacts with the first binding molecule wherein the charged nanoparticle is configured to apply a field effect on the field effect transistor. Moreover, the present invention provides a method of detecting an analyte by a biosensor. | 2022-08-11 |
20220252584 | METHODS AND DEVICES FOR DETECTING A PATHOGEN AND ITS MOLECULAR COMPONENTS - Methods, systems and devices for detecting the presence of a pathogen, for example, a virus (e.g., SARS-CoV-2), or its molecular components, in health care-related samples and/or environmental samples are disclosed. An example system for improving detection of a pathogen includes biosensor device comprising a detection chip and at least one probe that specifically recognizes a pathogen, where the detection chip comprises a graphene field-effect transistor (FET) chip and the probe, which comprises an aptamer, specifically binds to a DNA, RNA, or protein associated with the pathogen. | 2022-08-11 |
20220252585 | ANALYTE DETECTION IMMUNOASSAY - Provided herein are compositions, kits, and methods for performing analyte detection immunoassays. | 2022-08-11 |
20220252586 | COMPOSITIONS AND METHODS FOR DETECTING AND DEPLETING SAMPLE INTERFERENCES - The present specification provides methods to prepare reagents and microparticulate binding surfaces with specificity to anti-streptavidin interference and anti-biotin interference. Also disclosed is how to use reagents and microparticulate binding surfaces to block, deplete or reduce the concentration of anti-streptavidin interference and anti-biotin interference in samples below the assay blocking threshold (ABT) prior to a diagnostic test. | 2022-08-11 |
20220252587 | THERMAL SENSOR ARRAY FOR MOLECULE DETECTION AND RELATED DETECTION SCHEMES - Disclosed herein are methods of using detection devices. A detection device comprises a fluidic channel configured to receive a plurality of molecules to be detected, a plurality of temperature sensors, and an insulating material encapsulating the plurality of temperature sensors and providing a barrier between the plurality of temperature sensors and contents of the fluidic channel. A surface of the insulating material within the fluidic channel provides a plurality of sites for binding the plurality of molecules to be detected. Each of the plurality of temperature sensors is configured to detect, in the presence of an alternating magnetic field, a temperature change indicating presence or absence of one or more magnetic nanoparticles (MNPs) coupled to at least one of the plurality of molecules to be detected at a respective subset of the plurality of sites. | 2022-08-11 |
20220252588 | NEUTRALIZING ANTIBODY TESTING AND TREATMENT - A method for detection and measurement of neutralizing antibody levels to SARS-CoV-2 in a test-specimen, said method comprising obtaining a test-specimen from a subject, transferring the test-specimen to a sample well of a test-cassette, wherein the cassette further comprises a sample pad, a conjugate pad, a nitrocellulose membrane and an absorbent pad, wherein the sample pad comprises ACE2 or a functional fragment thereof, wherein the conjugate pad comprises a plurality of viral-ACE2-binding protein coupled to a plurality of labels, adding a buffer and reading the results from the test-cassette. | 2022-08-11 |
20220252589 | METHOD FOR DETERMINING THE INTERACTION BETWEEN A LIGAND AND A RECEPTOR - Described is a sample holder assembly including a functionalized test well wall, which may be used in combination with a light source. | 2022-08-11 |
20220252590 | REAGENT STORAGE IN AN ASSAY DEVICE - The invention relates to methods for conducting binding assays in an assay device that includes one or more storage and use zone. The storage zones of the assay device are configured to house one or more reagents used in an assay conducted in the use zone of the device. | 2022-08-11 |
20220252591 | LIQUID SAMPLE TESTING DEVICE - A liquid sample testing device includes: an upper case having: a hole allowing a liquid sample to be dropped in the hole; and a window to determine a test result, the hole and the window being located beside each other; a lower case assembled to the upper case; and a test strip housed between the upper case and the lower case. The upper case has: a first protrusion protruding toward the lower case; and a second protrusion protruding toward the lower case. The first protrusion and the second protrusion each has a predetermined shape to allow a capillary force generated between the second protrusion and the liquid sample to be larger than a capillary force generated between the first protrusion and the liquid sample. | 2022-08-11 |
20220252592 | DETECTION OF ANTI-p53 ANTIBODIES - The disclosure relates to an in vitro method for detecting an antibody to p53 (anti-p53 antibody) in a sample, the method comprising: incubating a sample to be analyzed with a p53 capture antigen and a p53 detection antigen, whereby a complex comprising the p53 capture antigen, the anti-p53 antibody and the p53 detection antigen is formed, separating the complex formed from unbound detection antigen and measuring the complex obtained via the detection antigen comprised therein, thereby detecting the anti-p53 antibody comprised in the sample. | 2022-08-11 |
20220252593 | Methods of Treating Transthyretin (TTR) Mediated Amyloidosis - Disclosed herein are methods for reducing or arresting an increase in a Neuropathy Impairment Score (NIS) or a modified NIS (mNIS+7) in a human subject by administering an effective amount of a transthyretin (TTR)-inhibiting composition. | 2022-08-11 |
20220252594 | GAMMA-DELTA T CELL LIGANDS FOR CANCER IMMUNOTHERAPY - Provided herein are compositions and methods relating to γδ T cells. Specifically, methods of screening samples for human γδ T cells surface ligands using a soluble human γδ T cell receptor tetramer are provided. Such ligands may be useful in the treatment of diseases, for example, cancer. | 2022-08-11 |
20220252595 | DIAGNOSTIC REAGENT - The invention provides a | 2022-08-11 |
20220252596 | IN VITRO METHOD FOR DISCRIMINATING LATENT FROM ACTIVE TUBERCULOSIS - In vitro method for discriminating latent from active TB. The present invention refers to an in vitro method for the differential diagnosis between active TB, preferably early stages of TB, and LTBI. | 2022-08-11 |
20220252597 | New Core/Shell Materials of Nanowire/Graphene on Low-Cost RFID Tags for Rapidly Sensing Live Cell Metabolites at Single-Cell Sensitivity - A biosensor having a core/shell nanocomposite of TiO2/rGO formed by hydrothermally coating reduced graphene oxide (rGO) flakes on titanate nanowires. | 2022-08-11 |
20220252598 | METHODS AND DEVICES FOR ANALYTE COLLECTION, EXTRACTION, CONCENTRATION, AND DETECTION FOR CLINICAL APPLICATIONS - In various embodiments devices and methods for the detection and/or quantification of clinically relevant pathogens (e.g., bacteria, fungi, viruses, etc.) are provided. In certain embodiments the device comprises a lateral-flow assay that detects the bacterium at a concentration of less than about 6×10 | 2022-08-11 |
20220252599 | COMPOSITIONS AND METHODS FOR TREATING CEREBRAL VASOSPASM - The present invention relates to the field of inflammation. More specifically, the present invention provides compositions and methods for treating cerebral inflammation and associated sequelae thereof including cerebral vasospasm. In one embodiment, a method for treating cerebral vasospasm in a patient comprises the step of administering to the patient a PD-1 agonist, wherein a blood sample obtained from the patient comprises elevated PD-1 expression on monocytes relative to a control. | 2022-08-11 |
20220252600 | EXOSOME-MEDIATED DIAGNOSIS OF HEPATITIS VIRUS INFECTIONS AND DISEASES - A method for diagnosing hepatitis virus infection or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers present on exosomes in a bodily fluid sample from the subject is disclosed. Also disclosed are a method for monitoring the course of a hepatitis virus infection or a hepatitis disease condition in a subject and a method for monitoring effectiveness of treatment to a subject with an anti-hepatitis virus agent based on hepatitis virus-associated biomarkers present on exosomes in bodily fluid samples from the subject, as well as a kit for diagnosing hepatitis virus infection and/or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers on exosomes in bodily fluid samples from the subject. | 2022-08-11 |