33rd week of 2013 patent applcation highlights part 46 |
Patent application number | Title | Published |
20130209967 | APPARATUS AND METHOD FOR OPERATING A FLIGHT SIMULATOR WITH A SPECIAL IMPRESSION OF REALITY - An apparatus for operating a simulator with a special impression of reality is provided. The apparatus is configured for learning how to control a vehicle moving in three-dimensional reality. Controllable systems for detecting human stress reactions are provided. The controllable systems may be configured for sensing the resistance of the skin and for detecting movements of persons and physiognomy. | 2013-08-15 |
20130209968 | LESSON BASED DRIVER FEEDBACK SYSTEM & METHOD - A feedback and training system for use in a vehicle the vehicle comprising or connected to one or more sensors enabled to measure one or more physical parameters associated with the vehicle; the system comprising a database, configured to receive and store data from the sensors, a processor enabled to calculate at least one performance factor based at least partly on the current physical parameters measured from the one or more sensors, a display configured to display to a driver representations of one or more of the performance factors, wherein the calculation of a performance factor, or the timing of or the prominence given to the display of the representation of a performance factor, is dependent on historic sensor data stored in the database received previously from the sensors. | 2013-08-15 |
20130209969 | Kit and a Method For Visualizing a Whitening Benefit of a Cosmetic Composition - A kit for visualizing to a consumer a whitening benefit provided by a cosmetic composition is provided. The kit comprises a control sample and a product sample, where each of the sample comprises a set of super absorbent polymer beads. The set of beads in the control sample are simultaneously or sequentially contacted with a control sample solution and a melanin generator, and the set of beads in the product sample are simultaneously or sequentially contacted with a product sample solution and a melanin generator. The control sample solution is free of whitening actives, and the product sample solution comprises one or more whitening actives. A method of visualizing to a consumer a whitening benefit provided by a cosmetic composition is also provided. | 2013-08-15 |
20130209970 | Method for Training Speech Recognition, and Training Device - Speech recognition is improved for wearers of hearing aids and other hearing devices by training the speech recognition. A first speech element is acoustically presented, and the element is identified by the person wearing the hearing device. Subsequently, the acoustic presentation of the presented speech element is automatically changed and the aforementioned steps are repeated (S | 2013-08-15 |
20130209971 | METHOD OF MANAGING HEALTH OF A USER BASED UPON DATA RELATED TO PHYSICAL, MENTAL AND SPIRITUAL STATUS - A method of managing health of a user includes receiving data related to weight change, net caloric intake, mental status, and spiritual status, all during the first time period. The method includes determining a moving average weight change per time increment per net caloric intake unit (MAWC) based upon the data related to weight change and net caloric intake. The method includes receiving a weight change goal and associated second time period. The method includes determining a recommended net caloric intake based upon the weight change goal and second time period, and the MAWC. The method includes receiving data related to weight change, net caloric intake, mental status, and spiritual status, all during the second time period. The method includes determining an activity recommendation based upon the received data related to the weight change, the net caloric intake, mental status, and spiritual status during the first and second time periods. | 2013-08-15 |
20130209972 | Providing Diet and Exercise Plans with Real Time Tracking, Modification, and Notification - The present invention extends to methods, systems, and computer program products for providing diet and exercise plans and for providing real time tracking and notifications of the user's conformance with a plan. The plan can be dynamically updated in real time based on the user's compliance with the plan. In some embodiments, the present invention can be implemented using a user's mobile phone that communicates with one or more other computing devices that are incorporated into exercise devices. | 2013-08-15 |
20130209973 | Methods and Systems for Tracking Words to be Mastered - A method for tracking words to be mastered includes transmitting, by a first computing device, to a second computing device, a word for reading by a user of the second computing device. The method includes receiving, by the first computing device, from the second computing device, an indication that the user requested assistance with sight-reading the word. The method includes adding, by the first computing device, the word to an enumeration of words the user has not mastered. The method includes providing, by the first computing device, to an instructor of the user, the enumeration of words the user has not mastered. | 2013-08-15 |
20130209974 | Exemplar Descriptions of Homophones to Assist Visually Impaired Users - The disclosed implementations provide systems, methods and computer program products that provide computer accessibility for visually impaired users by audibly presenting exemplary descriptions of homophones. Commonly used characters can be described by using a common multi-character word that includes the character. Rarely used characters can be described using an Ideographic Description Sequence (IDS) that splits characters into individual components. Each component can then be read aloud individually as a description of the homophone character. | 2013-08-15 |
20130209975 | HAZARDOUS MATERIAL RESPONSE SYSTEM, METHOD OF USING SAME AND METHOD OF TRAINING FOR SAME - This application describes methods for responding to a hazardous material based upon its properties and/or its chemical name. This application also describes methods of teaching hazardous material responders how to use the method of responding to a hazardous material based upon its properties and/or its chemical name. | 2013-08-15 |
20130209976 | VIRTUAL REALITY PIPE WELDING SIMULATOR AND SETUP - A simulator facilitates virtual welding activity of orbital weld joints. The simulator may include a logic processor based system operable to execute coded instructions for generating an interactive welding environment that emulates welding activity on a section of virtual pipe having at least one virtual weld joint. It also includes a display connected to the logic processor based system for visually depicting the interactive welding environment, wherein the display depicts the section of virtual pipe. A pendant is provided for performing welding equipment setup and virtual welding activity on the at least one weld joint in real time where one or more sensors are adapted to track movement of the input device in real time for communicating data about the movement of the input device to the logic processor based system. | 2013-08-15 |
20130209977 | Performance Assessment Tool - Embodiments of the invention relate to cognitive performance and/or psychological assessment of a subject. Measurement of behavioral status and cognitive efficiency is based upon batteries of tests that include a combination of cognitive and/or psychological tests. A module is provided with a processing unit in communication with memory to administer the cognitive and/or psychological tests and to compute an assessment. Results of the assessment are conveyed on a visual display of the module. In some cases, additional sensor data may be added to the assessment. | 2013-08-15 |
20130209978 | REHABILITATION COACHING METHOD AND REHABILITATION COACHING SYSTEM - A rehabilitation coaching method and a rehabilitation coaching system are provided. The method includes setting an exercise rhythm according to personalized exercise rhythm data for the user, and outputting the exercise rhythm to coach the user to do a rehabilitation exercise. The method also includes obtaining a total oxygen consumption rate according to the profile of the user, the time of doing the rehabilitation exercise and the exercise rhythm, and obtaining an exercise intensity according to the resting heart rate of the user and an average heart rate of the user during the rehabilitation exercise. The method further includes obtaining a recommended exercise rhythm according to the exercise intensity and the total oxygen consumption rate, and updating the personalized exercise rhythm data for the user according to the recommended exercise rhythm. | 2013-08-15 |
20130209979 | Device for Assessing and Display of a Difference in Vectors of Forces Exercised by a Pair of Arms or Legs - A device for assessing and display of a difference in vectors of forces exercised by a pair of arms or legs of exercising persons, e. g. patients suffering from a damage of the musculoskeletal or nervous system or sportsmen comprises a housing ( | 2013-08-15 |
20130209980 | SYSTEMS AND METHODS FOR PROVIDING VIBRATION FEEDBACK IN ROBOTIC SYSTEMS - Systems and methods for training an operator of a robotic surgery system are disclosed. One such method includes enabling the operator to perform a test procedure, recording vibrations of a surgical tool of the robotic surgery system during the test procedure, and generating a score for the operator based at least in part on the recorded vibrations of the surgical tool. | 2013-08-15 |
20130209981 | Triggered Sounds in eBooks - Trigger point information is generated for an eBook to play sounds in an eBook. A request for trigger point information is received from a client. The eBook is analyzed to determine trigger point information for the eBook. The trigger point information includes location information identifying a location of a trigger point in the eBook. The trigger information also includes sound information indicating a sound to play at the trigger point. The determined trigger point information is transmitted to the client in response to the request for trigger point information. The client is configured to track a user's reading location in the eBook and play the sound indicated by the sound information responsive to the user reading the eBook at the location of the trigger point. | 2013-08-15 |
20130209982 | SYSTEM AND METHOD FOR MANAGING AND ADMINISTERING A HIGH STAKES TEST - A method of administering a high stakes test includes providing a proctor device and providing a plurality of response devices, with each response device being associated with one of a plurality of subjects. The method also includes beginning a test and receiving a plurality of signals at the proctor device from the plurality of response devices. The method further includes determining that a first response device associated with a first subject is non-functional and temporarily suspending the test to associate a second response device with the first subject, then resuming the test. | 2013-08-15 |
20130209983 | INTERACTIVE COMPUTER-ASSISTED STUDY/TEST/STUDY/TEST METHOD OF INSTRUCTION AND SYSTEM FOR IMPLEMENTATION - Disclosed is a testing and learning method comprising a testing system that registers a student as having passed a test when the student completes a testing option chosen from the group consisting of (1) answering one hundred percent of the questions in a set of questions within a required time, (2) answering one hundred percent of the questions in a series of sets of questions, but failing to answer any individual set of questions within the required time, and (3) providing a cumulative percentage of correct answers over a series of sets of questions. | 2013-08-15 |
20130209984 | METHODS AND SYSTEMS FOR ASSISTING IN TERMINAL LIFE DECISIONS - Methods and systems for assisting in terminal life decisions. The methods and systems include a guide completed by a user which will instruct selected people to make decisions on behalf of the user. | 2013-08-15 |
20130209985 | SAMPLE COLLECTION DEVICES WITH BLOOD STABILIZING AGENTS - Disclosed are devices for collecting and stabilizing blood or plasma and which contain an anti-coagulant, an antiplatelet agent, and a solubilization agent, and which may optionally include at least one other blood stabilization agent. Methods of making and using the devices in clinical medicine are also provided. | 2013-08-15 |
20130209986 | METHOD FOR ENHANCING BUTYRATE PRODUCTION BY CLOSTRIDIUM TYROBUTYRICUM - Disclosed is a method for enhancing a butyrate production by | 2013-08-15 |
20130209987 | OLIGONUCLEOTIDE SETS FOR DETECTION OF HUMAN PAPILLOMAVIRUS - Disclosed are methods and kits for detecting high risk HPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68, that are known to cause abnormal cell growth and cancer. The disclosed methods and kits allow a rapid and quantitative real-time PCR detection of all high risk strains of HPV in a single PCR reaction. The procedure promises to facilitate the rapid high throughput detection of high risk strains of HPV in a cost effective and reliable manner. | 2013-08-15 |
20130209988 | MICROFLUIDIC DEVICES FOR THE CAPTURE OF BIOLOGICAL SAMPLE COMPONENTS - Methods and systems for selectively capturing analytes, such as cells, e.g., circulating tumor cells (CTCs), from fluid samples are disclosed. The methods include contacting the sample with an analyte binding moiety that selectively binds to the analytes; optionally separating first components of the sample including a majority of the analytes bound to the binding moieties from second components of the sample using size-based separation, e.g., in a microfluidic channel; adding to the first components of the sample a plurality of binding agents under conditions that enable a plurality of the binding agents to be linked to the analyte binding moieties to form multivalent tagging agents bound to the analyte; passing the first components of the sample past a surface to which is attached a plurality of capture agents that selectively bind to the binding agents; and capturing the analytes by providing conditions that enable the multivalent tagging agents bound to the analytes to bind to one or more of the capture agents. | 2013-08-15 |
20130209989 | OLIGONUCLEOTIDE PRIMER COMPOSITION - Oligonucleotide primer useful for synthesizing a cDNA copy of HIV-1 nucleic acids from a broad range of HIV-1 subtypes, including M group and O group variants. | 2013-08-15 |
20130209990 | DETECTION OF NUCLEIC ACIDS BY TYPE-SPECIFIC HYBRID CAPTURE METHODS - Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but is also highly specific and capable of discriminating highly homologous nucleic acid sequences. The method produces DNA/RNA hybrids which can be detected by a variety of methods. | 2013-08-15 |
20130209991 | WIRELESS SWNT SENSOR INTEGRATED WITH MICROFLUIDIC SYSTEM FOR VARIOUS LIQUID SENSING APPLICATIONS - Sensors based on single-walled carbon nanotubes (SWNT) are integrated into a microfluidic system outfitted with data processing and wireless transmission capability. The sensors combine the sensitivity, specificity, and miniature size of SWNT-based nanosensors with the flexible fluid handling power of microfluidic “lab on a chip” analytical systems. Methods of integrating the SWNT-based sensor into a microfluidic system are compatible with the delicate nature of the SWNT sensor elements. The sensor devices are capable of continuously and autonomously monitoring and analyzing liquid samples in remote locations, and are applicable to real time water quality monitoring and monitoring of fluids in living systems and environments. The sensor devices and fabrication methods of the invention constitute a platform technology, because the devices can be designed to specifically detect a large number of distinct chemical agents based on the functionalization of the SWNT. The sensors can be combined into a multiplex format that detects desired combinations of chemical agents simultaneously. | 2013-08-15 |
20130209992 | METHODS OF NONSPECIFIC TARGET CAPTURE OF NUCLEIC ACIDS - Methods for capturing a target nucleic acid from a sample by using a capture probe that binds nonspecifically to the target nucleic acid and binds specifically to an immobilized probe via a specific binding pair that has one member on the capture probe and one member on the immobilized probe are disclosed. Compositions that include a capture probe that binds nonspecifically to a target nucleic acid and specifically to an immobilized probe via binding of members of a specific binding pair in a solution phase of a reaction mixture are disclosed. | 2013-08-15 |
20130209993 | SAMPLE COLLECTION SYSTEM AND METHOD FOR USE THEREOF - A sample collection system capable of collecting, storing and dispensing a liquid sample is disclosed. The collection system includes a collector composed of a material which has the unique ability to express constituents of interest at levels which are much more concentrated than their levels in the fluid samples from which they are expressed, where the expressed highly concentrated sample can then be used with modern rapid screening/testing protocols, such as solid phase assays, to test for the constituents of interest. Thus, it is now possible to obtain analytes of interest, such as the HIV protein antibodies, from saliva samples at concentrations that are detectable with systems and/or devices that are typically utilized only for blood serum or plasma testing. The collector is sized and shaped to fit within a recovery container, which, in turn, is sized and shaped to fit within a collection tube. The recovery container includes an aperture which does not permit passage of fluid under ambient conditions, but facilitates transfer thereof when subjected to pressure. An optional channel within the collection tube facilitates dispensing of the sample for further processing. | 2013-08-15 |
20130209994 | FLUORESCENT DYES - The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified to provide beneficial properties. | 2013-08-15 |
20130209995 | Laboratory Apparatus for Treating a Sample Reception Section with a Magnetic Tool Device, Magnetic Tool Device, Sample Reception Device for Use with the Magnetic Tool Device and Method for Performing a Work Step on at Least One Fluid Sample Using a Magnetic Field - The invention is related to a laboratory apparatus and method for magnetic treatment of samples, comprising a sample reception device, which has reception zones and engagement zones, which are arranged side by side, and which has a magnetic tool device, which comprises at least one engagement element for at least partly engaging with the at least one engagement zone, wherein the reception device and/or the magnetic tool device or engagement element are arranged movable between a first and a second position for performing a movement which causes the at least one engagement element to at least partly engage the at least one engagement zone, wherein, in the first position, the engagement element does not engage, while in the second position, the engagement element is at least partly engaging with the engagement zone for the magnetic treatment. The invention is also related to the reception device and the magnetic tool device. | 2013-08-15 |
20130209997 | COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN SALIVA AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES - Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated saliva samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA following the storage period. | 2013-08-15 |
20130209998 | Microbial Assay - A method of detecting genetic material deriving from | 2013-08-15 |
20130209999 | SQSTM1 MUTATIONS IN AMYOTROPHIC LATERAL SCLEROSIS - Provided herein is technology relating to diagnosing, monitoring, and treating disease and particularly, but not exclusively, to methods, compositions, and kits for diagnosing, monitoring, and treating amyotrophic lateral sclerosis by detecting and identifying mutations in the gene SQSTM1 and providing therapies by targeting aberrant biological functions related to mutant forms of SQSTM1. | 2013-08-15 |
20130210000 | NEUROGENIC AND GLIOGENIC FACTORS AND ASSAYS THEREFOR - Disclosed herein are quantitative assays for measuring the potential of a substance, or a source of a substance, to promote neurogenesis and gliogenesis. Substances that promote neurogenesis and gliogenesis are also disclosed. | 2013-08-15 |
20130210001 | SEQUENCE DETECTION ASSAY - There is provided a method of detecting the presence in a sample of a first target sequence and a second target sequence within a test region of a nucleic acid sequence comprising conducting a nucleic acid amplification reaction, to form a forward amplicon strand and a reverse amplicon strand of the test region, contacting the forward amplicon strand with a first probe labelled with a first FRET label and capable of hybridising to the first target sequence of complement thereof in the forward amplicon strand, and contacting the reverse amplicon strand with a second probe labelled with a second FRET label and capable of hybridising to the second target sequence or complement thereof in the reverse amplicon strand; wherein the nucleic acid amplification reaction is conducted using a forward amplification primer labelled with a third FRET label and a reverse amplification primer labelled with a fourth FRET label, the forward primer being incorporated into the forward amplicon strand and the second primer being incorporated into the reverse amplicon strand during the amplification reaction; and further wherein the first and third FRET labels form a FRET pair and the second and fourth FRET labels form a different FRET pair, each FRET pair comprising a donor label; the method further comprising the steps of exposing the sample to an excitation source having a wavelength which excites the donor label in the first FRET pair and the donor label in the second FRET pair, detecting fluorescence from the sample and relating this to the presence or absence of the first and second target sequences. | 2013-08-15 |
20130210002 | METHOD OF ANALYZING CELLULAR CHROMOSOMES - The present invention involves an analysis method of cellular chromosomes, particularly involves a method of analyzing whether a difference exists in the chromosome number between amniotic cells and standard cells by a sequencing method. | 2013-08-15 |
20130210003 | COMPOSITIONS FOR USE IN DETECTION OF MULTIPLE ANALYTES - Methods, compositions and kits are disclosed. The methods are directed to determining the presence or relative amounts of two or more components in a medium. A combination is provided comprising a medium suspected of containing the components, at least two sensitizer reagents and at least one reactive reagent activatable by singlet oxygen. The sensitizer reagents are capable of generating singlet oxygen and are distinguishable by wavelength of sensitization. The combination of sensitizer reagents and reactive reagents allows differential detection of the components. The sensitizer reagents are differentially activated. The amount of signal generated as a result of the activation of said reactive reagent is determined wherein the amount thereof is related to the amount of each of the components in the medium. | 2013-08-15 |
20130210004 | EGFR-RELATED POLYPEPTIDES AND METHODS OF USE - Described herein are truncated EGF receptor polypeptides, nucleic acids encoding them, and methods of using them to help select a method of treatment for an EGFR-related cancer, to predict clinical outcome, and to detect micrometastases or minimal residual disease. High EGFR expression and phosphorylated EGFR predicts poor survival in head and neck cancer patients, but does not correlate with advanced stage disease. In our studies, we determined that clinical biological correlates are likely to be more accurate when different aspects of EGFR are evaluated in combination. We analyzed EGFR phosphorylation, expression and mutations in 60 primary head and neck tumors. We not only found that head and neck tumors with either truncated or activated EGFR tend to have higher tumor and nodal stage, but also discovered three EGFR truncations. | 2013-08-15 |
20130210005 | METHOD FOR DETECTING MYCOBACTERIUM TUBERCULOSIS AND NONTUBERCULOUS MYCOBACTERIA BY USING DUAL REAL-TIME POLYMERASE CHAIN REACTION - Disclosed are a primer set and/or a probe capable of detecting specific nucleotide sequences of MTC and NTM, a kit for the detection of MTC and NTM, comprising the same, and a method for detecting MTC and NTM by duplex real-time PCR using the same. Useful in detecting genes characteristic of MTC and NTM, the primer sets and/or probes, detection kits, and detection methods can be applied as the clinical diagnosis of diseases caused by MTC and NTM, and therefore find applications in the medical fields including hospitals, research institutes, etc. | 2013-08-15 |
20130210006 | PERICARP DNA EXTRACTION AND MATRILINEAGE DETERMINATION - This disclosure concerns the separation of pericarp tissue from surrounding tissues in grain. Some embodiments concern the isolation of high-purity pericarp DNA from a grain plant that reflects the genotype of the maternal parent of the grain plant, such that the isolated DNA may be used in a PCR-based genotyping assay. | 2013-08-15 |
20130210007 | TREATMENT AND DIAGNOSIS OF EPIGENETIC DISORDERS AND CONDITIONS - The present disclosure relates generally to the field of epigenetics and in particular epigenetic profiles associated with a pathological condition. The present specification teaches screening of individuals and populations for epigenetic profiles associated with a pathological condition. The epigenetic profiles can be from an intron, an intron/exon boundary or a splicing region. Epigenetic profiles are disclosed from the following sites in the FMR locus: FREES, intron 2 of FMR1, the genomic FREE2 region as a whole or specific FREE2 fragments including FREE2 (D) or FREE2 (E). Kits and diagnostic assays are also taught herein as are computer programs to monitor changes in epigenetic patterns and profiles. Further enabled herein is a method for screening for agents which can reduce or mask the adverse effects of epigenetic modification and the use of these agents in therapy and prophylaxis. | 2013-08-15 |
20130210008 | METHOD FOR AMPLIFYING NUCLEIC ACIDS - The present invention describes methods for amplifying a target nucleic acid wherein target nucleic acids hybridise to capture probe nucleic acids which are immobilized to a support via their 5′ end. The hybridization product is further extended with a polymerase to form a double stranded nucleic acid. To this double stranded nucleic acid, a hairpin nucleic acid is ligated. This ligation product is further amplified and sequenced. | 2013-08-15 |
20130210009 | CONJUGATE BETWEEN A THIOPHILIC SOLID PHASE AND AN OLIGONUCLEOTIDE COMPRISING A THIOOXONUCLEOTIDE - An oligonucleotide-solid phase conjugate, wherein the solid phase is thiophilic and the oligonucleotide comprises at least one thiooxonucleobase according to Formula I, | 2013-08-15 |
20130210010 | RAPID SALMONELLA SEROTYPING ASSAY - Processes for the serotype specific detection and identification of one or more | 2013-08-15 |
20130210011 | METHODS AND BIOMARKERS FOR DETECTION OF BLADDER CANCER - The invention relates to methods and biomarkers (e.g., epigenetic biomarkers) for detection of bladder cancer in biological samples (e.g., tissue samples, urine samples, urine sediments). In some embodiments, methods and biomarkers of the present invention find use in discriminating between bladder cancer, prostate cancer and renal epithelial tumors. | 2013-08-15 |
20130210012 | METHOD FOR ASSESSING BREAST CANCER SUSCEPTIBILITY - The present invention aims to provide a method for determining breast cancer susceptibility, in which a DNA copy number polymorphism associated with breast cancer susceptibility is identified and determination is made based on an increase or decrease in the DNA copy number polymorphism. The present invention attempts to achieve this by performing microarray assay using the peripheral blood of sporadic breast cancer patients, identifying a DNA copy number polymorphism associated with breast cancer susceptibility in a chromosomal region, detecting the number of copies of the above DNA copy number polymorphism by quantitative PCR, and then determining breast cancer susceptibility based on an increase or decrease in the DNA copy number polymorphism. Furthermore, the precision of the determination of breast cancer susceptibility can be improved by detecting a DNA copy number polymorphism by the aforementioned quantitative PCR by selecting two or more chromosomal regions and then performing a discriminant analysis based on the results thus obtained. | 2013-08-15 |
20130210013 | REAL TIME GENE EXPRESSION PROFILING - The invention relates to methods of monitoring the amplification of one or more nucleic acid sequences of interest. More particularly, the invention relates to methods of monitoring the amplification of sequences of interest in real time. The methods disclosed herein provide methods for monitoring the amplification of one sequence or two or more sequences from a single sample, as well as methods for monitoring the amplification of one or more than one sequence from two or more samples. The monitoring methods of the invention permit improved determination of the abundance of one or more target nucleic acids, especially target RNA species, in one or more original samples. | 2013-08-15 |
20130210014 | METHOD FOR DETERMINING THE PROGNOSIS AND THERAPEUTIC RESPONSE IN CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) PATIENTS - The present invention is based on the seminal discovery that using next generation sequencing, PCR or the like, one of skill in the art can determine the prognosis for or predict responsiveness to a particular therapeutic regimen in a subject diagnosed with CLL. | 2013-08-15 |
20130210015 | SYSTEM AND METHOD FOR PROCESSING AND DETECTING NUCLEIC ACIDS - A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a capture plate and a capture plate module configured to facilitate binding of nucleic acids within the set of biological samples to magnetic beads; a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols; and an assay strip configured to combine nucleic acid samples with molecular diagnostic reagents for analysis of nucleic acids. | 2013-08-15 |
20130210016 | NUCLEIC ACID DETECTION AND RELATED COMPOSITIONS METHODS AND SYSTEMS - Provided herein are methods and systems for loop-mediated isothermal amplification of target polynucleotides on a sample without sample preparation. Methods and systems herein described also allow detection of cells and in particular bacterial cells on an untreated sample comprising the cells, and allow in some embodiments specific detection of bacterial cells such as | 2013-08-15 |
20130210017 | MARKERS FOR DETERMINING CHONDROCYTES - A method of determining identity, purity and/or potency of chondrocytes in vitro includes a) isolating and, optionally, culturing chondrocytes from a biological sample, and b) determining gene expression of at least one marker in the chondrocytes selected from the group consisting of FLT-1, IL-1beta, BSP-2, and type I collagen. | 2013-08-15 |
20130210018 | Polymer Particle - A particle [ | 2013-08-15 |
20130210019 | HELICASE DEPENDENT ISOTHERMAL AMPLIFICATION USING NICKING ENZYMES - The present invention relates to a method for amplifying a template nucleic acid, wherein the method comprises amplifying said template nucleic acid using the helicase dependent amplification (HDA) reaction in the presence of a nicking endonuclease, and wherein said template nucleic acid comprises a sequence recognized by said nicking endonuclease or a sequence recognized by said nicking endonuclease is introduced into the template nucleic acid during the HDA reaction. The invention further pertains to a kit for amplifying a nucleic acid, comprising a nicking endonuclease, a helicase and a DNA polymerase. | 2013-08-15 |
20130210020 | SYSTEMS AND METHODS FOR MONITORING THE AMPLIFICATION AND DISSOCIATION BEHAVIOR OF DNA MOLECULES - The present invention relates to systems and methods for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules. The present invention in one embodiment provides a system that includes a microfluidic channel comprising a PCR processing zone and an HRTm analysis zone; and an image sensor having a first image sensor region having a first field of view and a second image sensor region having a second field of view, wherein the second field of view is different than the first field of view, wherein at least a portion of the PCR processing zone is within the first field of view; and at least a portion of the HRTm analysis zone is within the second field of view. | 2013-08-15 |
20130210021 | Isolated Staphylococcus Pseudolugdunensis - Disclosed is an isolated strain of a previously unknown | 2013-08-15 |
20130210022 | METHOD OF IDENTIFYING AN AGENT FOR INHIBITING ODOR OF PYRAZINE DERIVATIVES - A method to identify an agent for reducing an odor of a pyrazine derivative, comprising:
| 2013-08-15 |
20130210023 | NUCLEIC ACID APTAMERS AGAINST PLASMODIUM LACTATE DEHYDROGENASE AND HISTIDINE-RICH PROTEIN II AND USES THEREOF FOR MALARIA DIAGNOSIS - The present invention provides nucleic acid aptamers that bind to | 2013-08-15 |
20130210024 | COMBINATION TREATMENT OF CANCER - The present technology relates to a method of treating cancer by sensitizing human tumours to DNA damaging therapies through activating FBXO32 expression. Transactivation of FBXO32 through the inhibition of EZH2, a histone methyltransferase, decreases p21 protein induction which results in the sensitization of human tumours to chemotherapy. The method further provides a prognostic method to determine if a combination treatment would be effective. | 2013-08-15 |
20130210025 | Lateral Flow Assays - Assays and methods including mobile tagged single stranded nucleic acid reagents pre-loaded on an analysis device, which are preferably tagged, but not labeled and are complementary to a strand (preferably the anti-sense strand in double stranded DNA targets) of the target nucleic acid. The assay also includes a running buffer that includes a dye or other detectable label that nonspecifically binds only to double stranded nucleic acids. In addition, the analysis device includes a detection zone including one or more test zones that have an immobilized tag that binds to the tag on the mobile nucleic acid reagent. | 2013-08-15 |
20130210026 | BIOLOGICAL MARKERS PREDICTIVE OF ANTI-CANCER RESPONSE TO KINASE INHIBITORS - The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with inhibitors of EGFR kinase, PDGFR kinase, or FGFR kinase. Based on the surprising discovery that tumors cells after having undergone an EMT, while being mesenchymal-like, still express characteristics of both epithelial and mesenchymal cells, and that such cells have altered sensitivity to inhibition by receptor protein-tyrosine kinase inhibitors, in that they have become relatively insensitive to EGFR kinase inhibitors, but have frequently acquired sensitivity to inhibitors of other receptor protein-tyrosine kinases such as PDGFR or FGFR, methods have been devised for determining levels of specific epithelial and mesenchymal biomarkers that identify such “hybrid” tumor cells (e.g. determination of co-expression of vimentin and epithelial keratins), and thus predict the tumor's likely sensitivity to inhibitors of EGFR kinase, PDGFR kinase, or FGFR kinase. Improved methods for treating cancer patients with EGFR, PDGFR or FGFR kinase inhibitors that incorporate such methodology are also provided. | 2013-08-15 |
20130210027 | TEST SYSTEM AND METHOD - The present invention relates to an apparatus for detecting compounds, the apparatus having a device defining a disk-shaped geometry, the device having a centre, a plurality of fluid channels each comprising a fluid inlet positioned at a first distance from the centre and a fluid channel end at a second distance from the centre, the second distance being larger than the first distance, one or more sensors arranged at each fluid channel, wherein the sensors each comprise at least one optical detectable member, the test apparatus further comprising one or more optical sensing devices arranged for sensing the at least one optical detectable member of the one or more sensors, and a rotation device adapted for rotating the device so that the sensors pass over the one or more optical sensing devices. Further the present invention relates to a method for determining compounds comprising providing an apparatus for detecting compounds having a device defining a disk-shaped geometry, the device having a centre, a plurality of fluid channels each comprising a fluid inlet positioned at a first distance from the centre and a fluid channel end at a second distance from the centre, the second distance being larger than the first distance, one or more sensors arranged at each fluid channel, wherein the sensors each comprise at least one optical detectable member, the test apparatus further comprising one or more optical sensing devices arranged for sensing the at least one optical detectable member of the one or more sensors, and a rotation device adapted for rotating the device so that the sensors pass over the one or more optical sensing devices, the method comprising: providing a fluid at an inlet near the centre of the device, rotating the device, and obtaining properties of the sensors using the optical sensing devices. | 2013-08-15 |
20130210028 | Biological Assays Using Microparticles - Encoded microparticles described are useful in the study of many different biological agents in multiplex assays. For instance, the encoded microparticles may be employed in various co-precipitation assays to purify and/or isolate various analytes of interest. Encoded microparticles may also be used as real-time detectors in many different situations whereby binding of a secreted analyte or contaminating analyte may be detected using various labeling techniques. Further, encoded microparticles may be attached in a specific manner to particular cell types, for instance in a heterogeneous mixture of cells, either fixed in tissue or circulating, to allow identification, localization and/or sorting of the cells in the context of various biological events under various environments or conditions. | 2013-08-15 |
20130210029 | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE IN A NON-SURGICAL ICU POPULATION - The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects admitted to a hospital critical care setting for other than a post-surgical or trauma indication. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of Insulin-like growth factor IA, soluble Epidermal growth factor receptor, and Leukocyte elastase as diagnostic and prognostic biomarkers in renal injuries. | 2013-08-15 |
20130210030 | IN VIVO METHOD FOR THE EVALUATION OF A COMPOUND-TARGET INTERACTION - The invention relates to a method for evaluation of a compound-target interaction in vivo, comprising the steps of administering the compound to an animal, taking a body fluid sample of the animal, determining the concentration of the compound in the body fluid sample, taking a cellular sample of the animal containing the target, preparing a protein preparation of said cellular sample, providing an immobilised ligand capable of binding to the target, contacting the protein preparation with the immobilised ligand under conditions allowing the formation of a complex between the immobilised ligand and the target, determining the amount of complexes formed in step, and correlating the amount of complexes with the concentration of the compound in the body fluid sample. | 2013-08-15 |
20130210031 | DETECTION OF ADENYLATE CYCLASE - One major problem in diagnosis methods presently available for anthrax is that these methods require several days to produce a result, are rendered unusable after antibiotic use, or are not quantifiable. The only existing treatment for anthrax requires administration soon after infection at a time when patients are exhibiting only mild flu-like symptoms. Thus, by the time a diagnosis is made a patient may be days beyond the time when treatment would be effective. The present invention reduces diagnosis time to as little as four hours providing same day identification of anthrax radically increasing the odds of delivering proper treatment and patient recovery. The rapid identification of anthrax edema factor activity exhibited by the invention is also amenable to in vivo screening protocols for the discovery and development of anthrax vaccines, anti-toxins and edema factor inhibitors. The invention isolates and concentrates edema factor and edema toxin from nearly any sample. By capitalizing on the adenylate cyclase activity of edema factor the invention amplifies output signals producing reliable detection of low concentrations of edema factor previously unachievable. The invention involves novel purification and detection techniques and substrates for rapid, reproducible, and quantitative measurements of anthrax edema factor, and other adenylate cyclases in biological samples. | 2013-08-15 |
20130210032 | DEVICE, SYSTEM AND METHOD FOR DETECTING A SENSORY PERCEPTION - A device for detecting a sensory perception with regard to an analyte, having a sensor system and an organic receptor cell for detecting the sensory perception. The organic receptor cell is designed to assume a cellular state, which depends on the analyte in contact with the receptor cell. The sensor system is designed to determine the cellular state and to output it to the cellular state signal, which indicates the cellular state. | 2013-08-15 |
20130210033 | MARKER FOR AMYOTROPHIC LATERAL SCLEROSIS, AND USE THEREOF - An object is to provide a biomarker specific to amyotrophic lateral sclerosis and a use thereof. Provided are a marker for amyotrophic lateral sclerosis containing a transmembrane glycoprotein nmb, and a method for detecting amyotrophic lateral sclerosis, which utilizes the marker, and the like. | 2013-08-15 |
20130210034 | COMPLEX PHOSPHOPROTEIN ACTIVATION PROFILES - The present specification discloses methods for determining a phosphoprotein activation profile in hematopoietic cells, methods for detecting a signal transduction activation state in an individual having or suspected of having a disease or condition associated with activation of a signal transduction pathway, methods for detecting leukemia, and kits for determining a phosphoprotein activation profile in a sample containing hematopoietic cells. | 2013-08-15 |
20130210035 | CHIP AND METHOD FOR DETECTING GLYCOSYLATED HEMOGLOBIN - The present invention relates to a chip and a method for detecting HbA1c. The detection chip comprises: a substrate; and a biomolecular layer disposed on the substrate, wherein the biomolecular layer comprises a first anti-hemoglobin antibody. The biomolecular layer can bind both the glycosylated hemoglobin and the hemoglobin in the blood sample. The method for detecting HbA1c of the present invention comprises the use of a bio-detection layer that comprises anti-glycosylated hemoglobin antibody and a second hemoglobin antibody with different epitope to differentiate the glycosylated hemoglobin from the total hemoglobin. Thus, the relative amount of glycosylated hemoglobin to hemoglobin can be detected by using the detection chip and the detection method of the present invention. | 2013-08-15 |
20130210036 | Controlling Fluid Flow Through An Assay Device - An assay device includes: a detection zone which includes a first set of projections which are capable of generating capillary flow. A wicking zone (WZ) has a capacity to receive liquid sample flowing from the detection zone and includes a second set of projections which are capable of generating capillary flow. The WZ is rectangular in shape and the longer side of the rectangle extends in the direction of flow to thereby reduce the pressure gradient in the assay device which increases the total flow time of liquid sample compared to a WZ having equal length sides and same volume. At least a portion of the second set of projections have at least one dimension selected from a diameter, a center-to-center spacing, or a gap between projections that is different from the first set of projections, and is selected to increase the total flow time of the sample. | 2013-08-15 |
20130210037 | METHODS OF DIAGNOSING AND TREATING AUTISM - The present invention provides diagnostic methods for determining the risk of developing an autism spectrum disorder (ASD) in a fetus or child by detecting in a biological sample from the mother antibodies that bind to one or more biomarkers selected from the group consisting of lactate dehydrogenase (LDH), guanine deaminase (GDA), collapsin response mediator protein 1 (CRMP1), stress-induced phosphoprotein 1 (STIP1), alpha subunit of the barbed-end actin binding protein Cap Z (CAPZA2), Y Box Binding Protein 1 (YBX1), eukaryotic translation and elongation factor 1A1 (EEF1A1), microtubule-associated protein Tau (MAPT), dihydropyrimidinase-like protein 2 (DPYSL2), dynamin 1-like protein (DNM1L), radixin (RDX), moesin (MSN), and ezrin (EZR). The invention further provides methods of preventing or reducing the risk of a fetus or child developing an ASD by administering to the mother an agent that blocks the binding of maternal antibodies to the one or more fetal biomarkers listed above or by removing from the mother antibodies that bind to the one or more fetal biomarkers. | 2013-08-15 |
20130210038 | Novel Method for Diagnosing Q-fever Using a Cellular Immunological Test - The present invention relates to a method for diagnosing Q-fever in a subject, the method comprising the steps of: (a) obtaining a sample from said subject, (b) contacting said sample with a source of a | 2013-08-15 |
20130210039 | BLOOD INSULIN RESISTANCE AND DIABETES MARKER PROGRANULIN, METHOD FOR ANALYZING CONCENTRATION OF PROGRANULIN IN BLOOD SAMPLE, AND METHOD FOR SCREENING FOR SUBSTANCE THAT IMPROVES INSULIN RESISTANCE AND IMPROVES OR SUPPRESSES DIABETES - The present invention provides a marker capable of detecting insulin resistance and diabetes in a collected blood sample, a method for analyzing said marker, a method for screening a substance improving insulin resistance, and improving or suppressing diabetes. A blood insulin resistance marker and a blood diabetes marker, which comprises a polypeptide comprising at least 15 continuous amino acids in an amino acid sequence constituting progranulin. A method for analyzing a blood marker, which comprises the steps of: measuring a concentration of an insulin resistance marker or a diabetes marker in a collected blood sample; and comparing the measured concentration with a normal blood concentration of the marker. A method for screening a substance improving insulin resistance, and improving or suppressing diabetes, which comprises the steps of: administering a candidate substance to a living body expressing insulin resistance or suffering from diabetes; measuring a blood concentration of a marker in the living body after administration; and comparing the measured concentration of the marker with a blood concentration of the marker not administered with the candidate substance. | 2013-08-15 |
20130210040 | DIAGNOSTIC METHOD - It has been demonstrated that the level of sST2 increases in pregnant females suffering from pre-eclampsia. Accordingly, the level of sST2 in a pregnant female can be used to assess risk of developing pre-eclampsia. | 2013-08-15 |
20130210041 | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE - The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a plurality of assays configured to detect a kidney injury marker as diagnostic and prognostic biomarkers in renal injuries. | 2013-08-15 |
20130210042 | DIAGNOSTIC AND PROGNOSTIC METHOD FOR HUMAN TAUOPATHIES - The present invention relates to a method for the diagnosis and/or prognosis of tauopathies, in particular Alzeimer's disease. The method is based on the detection and quantification of a 20-22 kDa NH2-tau fragment. | 2013-08-15 |
20130210043 | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE - The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Thymic stromal lymphopoietin, Vascular endothelial growth factor receptor 1, C-C motif chemokine 1, C-C motif chemokine 17, C-C motif chemokine 21, C-C motif chemokine 27, FLT-3 Ligand, Immunoglobulin G subclass 3, Interleukin-1 receptor type I, Interleukin-20, Interleukin-29, Interleukin-7, Platelet-derived growth factor A/B dimer, Platelet-derived growth factor A/A dimer, and MMP9:TIMP2 complex as diagnostic and prognostic biomarkers in renal injuries. | 2013-08-15 |
20130210044 | METHOD OF LIPID ASSAY AND REAGENT FOR USE THEREIN - A method of lipid assay characterized by assaying the lipids contained in a blood component in the presence of an organic silicon compound. The method can cause specific conditions for direct methods while satisfying requirements such as no influence on precision of assay, no burden on assay apparatus, and easy availability. | 2013-08-15 |
20130210045 | BIOMARKER FOR FATIGUE, AND USE THEREOF - Ratios of measured values of glucose, citrate, and cis-aconitate in a biological sample obtained from a subject to measured values of glucose, citrate, and cis-aconitate in a biological sample obtained from a healthy subject are calculated, and the glucose ratio, the citrate ratio, and the cis-aconitate ratio are used to evaluate and/or assess fatigue. Similarly, an isocitrate ratio, a succinate ratio, a malate ratio, and a lactate ratio are calculated, and these ratios are used together with the three ratios to evaluate and/or assess fatigue. This makes it possible to objectively and easily diagnose and evaluate fatigue. | 2013-08-15 |
20130210046 | SCREENING METHODS FOR COMPOUNDS THAT MODULATE THE ACTIVITY OF G-PROTEIN COUPLED RECEPTORS - The present invention relates to a screening system for modulators of GPCRs. Further it relates to recombinant vector systems for the heterologous expression of heterodimeric G-protein coupled receptors (GPCRs) in eukaryotic host cells. Preferably the functional expression of engineered GPCRs for the perception of sweet and L-amino acid taste or more preferably the use of these receptors for the identification of functional ligands is also encompassed. | 2013-08-15 |
20130210047 | SILICA NANOPARTICLES WITH AGGREGATION INDUCED EMISSION CHARACTERISTICS AS FLUORESCENT BIOPROBE FOR INTRACELLULAR IMAGING AND PROTEIN CARRIER - Provided herein are magnetic silica fluorescent nanoparticles and fluorescent silica nanoparticles comprising an aggregation induced emission luminogen and magnetite nanoparticles and use of the same as a fluorescent bioprobe for intracellular imaging and a protein carrier. Also provided are processes for preparing and fabricating the same. | 2013-08-15 |
20130210048 | METHOD OF DETECTING A BIOLOGICAL ACTIVITY - A method of detecting a biological activity is provided. The method includes contacting; in a liquid medium selected to facilitate a predetermined biological activity; a sample, an indicator reagent, and a substrate that receives and concentrates a biological derivative of the indicator reagent. The method further includes observing a portion of the substrate to detect the biological derivative. The method can be used to detect the presence or absence of a target cell. | 2013-08-15 |
20130210049 | Polymeric Support With Nanofeatures for Cell Culture - The invention provides a cell support device comprising a nanofiber structure disposed on a concave surface of a substrate. and the curvature of the substrate in combination with the nanotopography provided by the nanofiber support provides the necessary environmental cues that promote organization, growth, differentiation and morphogenesis of secretory epithelial cells, such as salivary gland epithelial cells. The nanotopography of the device is influenced by features of the nanofiber structure including nanofiber diameter, pore size, biochemical modification and curvature. | 2013-08-15 |
20130210050 | PROTEASE FOR PROTEOMICS - Provided herein is technology relating to proteases and proteomics and particularly, but not exclusively, to compositions comprising OmpT, methods of using OmpT, and methods of manufacturing OmpT for proteomics. | 2013-08-15 |
20130210051 | ANALYTE MASS SPECTROMETRY QUANTITATION USING A UNIVERSAL REPORTER - Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter. | 2013-08-15 |
20130210052 | A Soluble and Stable Human 5-Lipoxygenase - A soluble and stable form of 5-lipoxygenase (5-LOX) has been made, 5-Lox is the enzyme which initiates leukotriene biosynthesis by catalyzing the two-step transformation of arachidomc acid to leukotriene A4 (LTA4). The soluble and stable 5-LOX is suitable for a number of applications, including, but not limited to, high throughput screening of 5-LOX inhibitors, structural analysis of the enzyme's active site, designing inhibitors based on the three-dimensional structure of the enzyme's active site, and synthesis of LTA4. Using Stable-5-LOX, the crystal structure for 5-LOX has been resolved and the amino acids defining the active site determined. | 2013-08-15 |
20130210053 | MECHANOCHROMIC LUMINESCENT DIFLUOROBORON BETA-DIKETONATES - The invention provides luminescent solid-state compositions comprising difluoroboron beta-diketonates wherein the compositions can exhibit mechanochromic luminescence. The mechanochromic effect on the luminescence can be reversible, such as thermally reversible. Various solid-state forms of the invention can have emission spectra that differ from the properties of the respective difluoroboron beta-diketonate in solution. The mechanochromic effect can be stimulated by pressure such as hand-writing, and can be reversed over a period of minutes to hours at room temperature. The invention also provides methods of making and methods of using the solid-state compositions, such as for sensors and for information displays for use in biological sensing, and in art, design, and consumer products. Compositions of the invention, such as compositions in nanoparticulate form, or contained within a matrix material, can be used in conjunction with fluorescence microscopy to provide information concerning pressures and tensions within and external to living cells, tissues, or organisms. | 2013-08-15 |
20130210054 | Amino Acid Copolymer Assay - The present disclosure relates to polarized type 2 T helper (Th2) cells and methods for using such cells in the assessment of antigenic compositions. | 2013-08-15 |
20130210055 | SYSTEM AND METHOD FOR STUDYING EPIDERMIS SAMPLES EX VIVO - An epidermal sample is placed into a sample holder formed as a sandwich assembly. The sample holder is placed in an upper well within a lower well to be exposed to media in both wells. Properties of the sample can be studied, such as paracellular flux, transepidermal electric resistance, reaction to compounds, and epidermal barrier recovery. | 2013-08-15 |
20130210057 | USE OF LABEL-FREE BIOSENSORS TO UNDERSTAND AND IDENTIFY TREATMENT FOR CANCER - The disclosure relates to methods of using dynamic mass redistribution data obtained from cancer cells cultured on waveguide grating biosensors in the presence of agonists and in the presence of chemotherapeutic agents, for predicting effective chemotherapies for the treatment of cancer. | 2013-08-15 |
20130210058 | SYSTEM FOR NONINVASIVE DETERMINATION OF WATER IN TISSUE - An apparatus and method for non-invasive determination of hydration, hydration state, total body water, or water concentration by quantitative spectroscopy. The system includes subsystems optimized to contend with the complexities of the tissue spectroscopy, high signal-to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance, and calibration transfer. The subsystems include an illumination subsystem, a tissue sampling subsystem, a spectrometer subsystem, a data acquisition subsystem, a computing subsystem, and a calibration subsystem. | 2013-08-15 |
20130210059 | Method for Selecting Mevalonate Synthesis Modulators Using Cells Derived From Human Pluripotent Cells - A method for selecting pharmaceutical compounds affecting mevalonate or cholesterol, comprising a step for putting into contact with the pharmaceutical compounds to be tested, cells of the MSC type obtained by a method for producing cells of the MSC type from human pluripotent cells or from induced stem cells, comprising a step for cultivating human pluripotent cells or induced stem cells in a culture medium comprising:
| 2013-08-15 |
20130210060 | METHOD OF PRODUCING PANCREATIC HORMONE-PRODUCING CELLS - Disclosed is a production method of pancreatic hormone-producing cells in a form that mimics the pancreatogenesis, the method comprising subjecting stem cells to the following steps: (1) cultivating stem cells in a medium containing a Rho kinase inhibitor, (2) cultivating the cells obtained in (1) in a medium containing a GSK3 inhibitor, (3) cultivating the cells obtained in (2) in a medium containing GSK3 inhibitor and an activator of activin receptor-like kinase-4,7, (4) forming a cell mass from the cells obtained in (3), and cultivating the cell mass in a suspension state in a medium, (5) cultivating the cells obtained in (4) in a medium containing a retinoic acid receptor agonist, an inhibitor of AMP-activated protein kinase and/or activin receptor-like kinase-2,3,6, an inhibitor of activin receptor-like kinase-4,5,7 and a cell growth factor, and (6) cultivating the cells obtained in (5). | 2013-08-15 |
20130210061 | Method of Screening Damp-Dry Malodor Inhibitor and Method of Evaluating Damp-Dry Malodor Inhibitor - A method of screening a damp-dry malodor inhibitor, containing the steps of: bringing microorganisms having a 4-methyl-3-hexenoic acid production capacity into contact with a test substance in the presence of a sebaceous dirt component, detecting the production of a damp-dry malodor-causing substance by the microorganisms, and thereby selecting a test substance having a damp-dry malodor inhibitory function; and a method of evaluating a damp-dry malodor inhibitor, containing the steps of: bringing microorganisms having a 4-methyl-3-hexenoic acid production capacity into contact with a test substance in the presence of a sebaceous dirt component, detecting the production of a damp-dry malodor-causing substance by the microorganisms, and thereby evaluating the damp-dry malodor inhibitory function of the test substance. | 2013-08-15 |
20130210062 | In Vitro Cellular Bioassay for Neurotoxicity Testing - The present invention provides neurotoxicity and developmental neurotoxicity screening methods employing primary cultured neurons from | 2013-08-15 |
20130210063 | COMPOSITIONS AND ASSAYS FOR DETERMINING CELL VIABILITY - Provided are compositions and methods useful in evaluation of cell health and metabolism, cell viability, proliferation, and the effects of compounds on these qualities. The assays provided are rapid, robust, nontoxic and suitable for use with high throughput devices. | 2013-08-15 |
20130210064 | MAGNETOTACTIC ALGAE AND METHODS OF USE - Disclosed herein are magnetotactic algae, such as algae cells that include magnetic nanoparticles. In some examples the magnetotactic algae express a nucleic acid molecule encoding a bacterial MagA ferrous transporter, a nucleic acid molecule encoding a bacterial Mms6 magnetite binding protein, or both. Also disclosed herein are methods for producing magnetotactic algae and methods of producing biofuel or magnetic nanoparticles utilizing magnetotactic algae. Further disclosed herein are methods of enriching a population of magnetotactic algae cells (for example, increasing the number of magnetotactic algae cells in a population of algae cells). In further embodiments, disclosed herein are methods of selecting a transformed algae cell. | 2013-08-15 |
20130210065 | TETRAZOLIUM COMPOUND FOR DETECTING MICROORGANISMS, REAGENT FOR DETECTING MICROORGANISMS AND METHOD FOR DETECTING MICROORGANISMS - The object of the present invention is to provide a compound used in a reagent for detecting microorganisms, by which microorganisms can be rapidly and reliably detected without requiring any special instrument, the reagent for detecting microorganisms, and a method for detecting microorganisms. The object can be achieved by a tetrazolium compound represented by general formula (I) below: | 2013-08-15 |
20130210066 | APPARATUS AND METHOD FOR EARLY DIAGNOSIS OF CELL DEATH - An apparatus for measuring through optical means temporally resolved, optical properties, and/or phenotypes, linked to cellular homeostasis. Those temporal measurements enable the detection of cell regulation through various channels linked to homeostasis, in order to assess cell viability or early cell death through rapid diagnostic. | 2013-08-15 |
20130210067 | METHOD OF DETECTING A BIOLOGICAL ACTIVITY - The present invention provides method of detecting a predetermined biological activity. The method includes using an aqueous mixture comprising a first indicator reagent with a first absorption spectrum and a second indicator reagent. The second indicator reagent is converted by the predetermined biological activity to a second biological derivative with a second emission spectrum. The first absorbance spectrum includes detectable absorbance in at least a portion of wavelengths present in the second emission spectrum. The first indicator reagent is received and concentrated from an aqueous liquid by a substrate, facilitating the detection of the second biological derivative. | 2013-08-15 |
20130210068 | SUBSTRATE USED FOR CELL MIGRATION ASSAYS AND METHOD FOR CELL MIGRATION ASSAYS - This invention provides a means for cell migration assays by regulating the cells adhered to a substrate so that they migrate to a given region, which is a substrate used for cell culture comprising: a base material comprising a conductive region and an insulating region provided thereon and cell-adhesive regions and non-cell-adhesive regions provided in the conductive region and the insulating region, respectively, wherein a cell-adhesive region is positioned adjacent to a non-cell-adhesive region in the conductive region, and a cell-adhesive region is positioned adjacent to a non-cell-adhesive region in the insulating region. | 2013-08-15 |