33rd week of 2022 patent applcation highlights part 11 |
Patent application number | Title | Published |
20220257766 | SSTR-TARGETED CONJUGATES AND FORMULATIONS THEREOF - Conjugates of an active agent such as DM1 attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker, have been designed. Such conjugates can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer. | 2022-08-18 |
20220257767 | IONIC LIQUIDS FOR DRUG DELIVERY - The technology described herein is directed to ionic liquids and methods of drug delivery. | 2022-08-18 |
20220257768 | TREATMENT OF IMMUNE EVASIVE TUMORS - The present disclosure provides methods of treating immune evasive cancers using surface functionalized particles alone or in combination with cancer therapeutics. | 2022-08-18 |
20220257769 | Porous Self-Healing Polymer Matrix For Encapsulation Of Active Macromolecules And Methods - The present disclosure relates to a porous self-healing polymer matrix for encapsulation of active macromolecules and a method of manufacturing said porous self-healing polymer matrix for a drug delivery system for a macromolecule. | 2022-08-18 |
20220257770 | HYDROPHOBIC HIGHLY BRANCHED CARBOHYDRATE POLYMERS - A material comprising a highly branched carbohydrate polymer, a polyalkylene glycol (or polyalkylene oxide) linked to the highly branched carbohydrate polymer, and a hydrophobic or amphiphilic group linked to the highly branched carbohydrate polymer and/or the polyalkylene glycol (or polyalkylene oxide), is described. Methods of making and using the material, as well as a soluble composition that contains the material and a hydrophobic solute compound, are also described. | 2022-08-18 |
20220257771 | COMPOSITIONS COMPRISING LOPINAVIR AND TREATMENT OF CONDITIONS - Provided herein are methods and compositions for treating and/or inhibiting the development or progression of conditions caused by, or associated with, Herpes Simplex Virus (HSV)infection. In particular, provided are compositions comprising lopinavir alone, or lopinavir and ritonavir, methods for their manufacture; and the use of said pharmaceutical compositions as a medicament. In particular, pharmaceutical compositions are provided for use in treating and/or inhibiting the progression of HSV related conditions. | 2022-08-18 |
20220257772 | PREPARATION OF LIPOPHILIC ACTIVE INGREDIENTS - The present disclosure relates to a formulation for a wide variety of poorly soluble drugs to improve bioavailability using a solid self-emulsifying drug delivery system. Compositions of the present disclosure can be used for improved delivery of hydrophobic or lipophilic pharmaceutical active ingredients, such as drugs, nutritional agents, cosmeceuticals, and diagnostic agents. | 2022-08-18 |
20220257773 | ACID TYPE SOPHOROLIPID-CONTAINING COMPOSITION WHICH IS SUPPRESSED IN BROWNING - The present invention provides an acidic sophorolipid-containing composition with suppressed browning and a method for producing the composition. The acidic sophorolipid-containing composition with suppressed browning according to the present invention is characterized in that a filtrate of a hydrolysate of a composition containing lactonic sophorolipid and acidic sophorolipid, i.e., a filtrate of the acidic sophorolipid-containing composition, has at least one of the following features (1) and (2):
| 2022-08-18 |
20220257774 | AROMATIC AMINE AR AHD BET TARGETING PROTEIN DEGRADATION CHIMERA COMPOUND AND USE - An aromatic amine androgen receptor (AR) and BET targeting protein degradation chimera compound is represented by formula I. Experimental results show that the compound can target and degrade both AR and BRD4, and down-regulate the expression of AR and BRD4 proteins; the compound can inhibit the proliferation of a variety of prostate cancer cells; the compound can inhibit the proliferation of a prostate cancer cell line LNCaP/AR, which overexpresses the AR, and can achieve a good inhibition effect on a prostate cancer cell line 22RV1, which is resistant to a marketed prostate cancer drug (enzalutamide). The compound also shows good metabolic stability, and has a good application prospect in the preparation of an AR and/or BET protein degradation targeting chimera, and a drug for the treatment of related diseases regulated by the AR and BET. | 2022-08-18 |
20220257775 | USE OF HIGHLY POTENT MULTIMERIC E-SELECTIN ANTAGONISTS FOR TREATING SICKLE CELL DISEASE - Methods for the treatment of sickle cell disease or complications associated therewith, including, for example, vaso-occlusive crisis, by the use of at least one E-selectin inhibitor and compositions comprising the same are disclosed. | 2022-08-18 |
20220257776 | ALK PROTEIN REGULATOR AND ANTI-TUMOR APPLICATION THEREOF - A compound of general formula (I), a compound of general formula (III) and anti-tumor applications thereof. A series of compounds designed and synthesized have a wide range of pharmacological activities, have the function of degrading specific proteins and/or inhibiting activity, and can be used in related tumor and cancer treatments. | 2022-08-18 |
20220257777 | HSP90-BINDING CONJUGATES AND COMBINATION THERAPIES THEREOF - The disclosure generally relates to a method of treating cancer comprising administering HSP90-binding conjugates or administering two distinct therapeutic agents as a combination therapy. Components of the combination therapy and methods of using the combination therapy are provided. | 2022-08-18 |
20220257778 | Beta-Lactam-Cannabinoid Conjugate Molecules - This disclosure provides multifunctional conjugate molecules in which at least one β-lactam antibiotic is covalently attached to a cannabinoid by means of a linker. The disclosed conjugate molecules are designed to deliver therapeutic benefits as intact molecules, with release of the cannabinoid upon binding of the β-lactam antibiotic to its target conveying further therapeutic benefits, and can be used to treat bacterial infections and other disorders. | 2022-08-18 |
20220257779 | PROTEIN COMPLEX COMPRISING NON-PEPTIDYL POLYMER-COUPLED FATTY ACID DERIVATIVE COMPOUND AS LINKER AND PREPARATION METHOD THEREFOR - Provided are a protein conjugate in which a physiologically active polypeptide is linked to a biocompatible material via a non-peptidyl polymer-coupled fatty acid derivative compound serving as a linker, exhibiting an increased duration of physiological activity compared to natural forms and a preparation method therefor. Since an increase in serum half-life of the physiologically active polypeptide of the protein conjugate, in which the biocompatible material, the non-peptidyl polymer-coupled fatty acid derivative compound, and the physiologically active polypeptide are linked, is proved, the protein conjugate may be widely used in the field of protein drugs. | 2022-08-18 |
20220257780 | MICRONIZED DRUG RESINATE-BASED PHARMACEUTICAL COMPOSITIONS AND METHODS OF PREPARATION THEREOF - This disclosure provides a pharmaceutical composition for oral administration, which comprises micronized ion-exchange resin particles having particle sizes less than 50 pm and at least one therapeutic agent releasably bound to the micronized resin particles through ionic interaction to form resin-therapeutic agent complexes. The resin-therapeutic agent complexes have particle sizes less than 50 pm, and the pharmaceutical composition is formulated as a dosage form providing uniform dispersion of the resin-therapeutic agent complexes with a substantially masked taste of the therapeutic agent, and a reduced gritty mouthfeel for geriatric patients and pediatric patients. | 2022-08-18 |
20220257781 | POLYMER CONJUGATE BONDED TO TERTIARY AMINE COMPOUND OR IMINE COMPOUND AND PRODUCTION METHOD THEREFOR - Provided is a compound as a compound obtained by conjugating a tertiary amine compound or an imine compound, which is useful as a drug, with a polymer, in which a structure D | 2022-08-18 |
20220257782 | PEPTIDE THERAPEUTICS FOR AUTOIMMUNE DISEASES AND INFLAMMATORY DISEASES - A peptide inhibiting a Toll-like receptor (TLR) signaling pathway is disclosed. The peptide strongly binds to a TIR-containing molecule to inhibit the TLR, in particular, the TLR4 signaling pathway. A fusion peptide in which a cell-penetrating peptide is conjugated to said peptide; a TLR4 antagonist comprising said peptide or said fusion peptide; and compositions and methods for preventing or treating autoimmune diseases or inflammatory diseases are disclosed. The peptide exhibits an inhibitory effect on a wide range of TLR signaling pathways including TLR4, blocks MyD88- and TRIF-dependent TLR4 pathways, and has a substantial disease-alleviating effect in mouse models of rheumatoid arthritis, psoriasis, systemic lupus erythematosus, and non-alcoholic steatohepatitis, and thus can be usefully utilized as therapeutics for immune-related diseases and inflammatory diseases that require negative control of TLR. | 2022-08-18 |
20220257783 | RECOMBINANT VACCINES AND USE THEREOF - The present invention relates to fusion molecules of antigens, the nucleic acids coding therefor and the use of such fusion molecules and nucleic acids. In particular, said invention relates to fusion molecules, comprising an antigen and the trans-membrane region and cytoplasmic region of a MHC molecule and/or the cytoplasmic region of a MHC or a SNARE molecule. | 2022-08-18 |
20220257784 | BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR EPHA2 - The present invention relates to polypeptides which are covalently bound to non-aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of the Eph receptor tyrosine kinase A2 (EphA2). The invention also relates to pharmaceutical compositions comprising said peptide ligands and to the use of said peptide ligands in preventing, suppressing or treating a disease or disorder characterised by overexpression of EphA2 in diseased tissue (such as a tumour). | 2022-08-18 |
20220257785 | KNOTTIN-IMMUNOSTIMULANT CONJUGATES AND RELATED COMPOSITIONS AND METHODS - Provided are conjugates comprising a knottin peptide comprising an engineered loop that binds to a cell surface molecule, and an immunostimulant conjugated to the knottin peptide via a linker. According to some embodiments, the immunostimulant activates a pathogen recognition receptor (PRR). For example, the immunostimulant may be a Toll-Like Receptor (TLR) agonist, e.g., an agonist of TLR 7, TLR 8 and/or TLR 9. Also provided are compositions (e.g., pharmaceutical compositions) that comprise the conjugates of the present disclosure, as well as kits comprising such compositions and methods of using such compositions, e.g., to treat an individual having cancer. Methods of making the conjugates of the present disclosure are also provided. | 2022-08-18 |
20220257786 | MULTICELLULAR TARGETING LIPOSOME - The present disclosure belongs to the field of the use of liposome preparations in the preparation of tumor drugs, and in particular, relates to the construction and use of a multicellular targeting liposome. Due to that a single liposome includes multiple antibodies against different cells, and a liposome with a stable structure and long circulation characteristics in vivo is constituted by molecular self-assembly, the multicellular targeting liposome can sequentially or simultaneously bind to multiple different cells by means of the action of antibodies to promote the identification of, communication between, the cytotoxicity of, the pro-apoptosis or clearance of different cells, etc. | 2022-08-18 |
20220257787 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS - Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., influenza viral infections). | 2022-08-18 |
20220257788 | NOVEL METHOD FOR PREPARING LONG-ACTING DRUG CONJUGATE THROUGH PREPARATION OF INTERMEDIATE - Provided is a novel method for preparing a long-acting drug conjugate and a long-acting drug conjugate prepared using the method. | 2022-08-18 |
20220257789 | ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATES AND RELATED METHODS - Provided herein are antibodies that specifically bind to human tissue factor (TF), anti-TF antibody-drug conjugates (ADCs), and compositions comprising the antibodies or ADCs. Also provided herein are methods of making and using the antibodies or ADCs, such as therapeutic and diagnostic methods. | 2022-08-18 |
20220257790 | MICELLAR NANOPARTICLES AND USES THEREOF - The present disclosure includes cationic carrier units comprising (i) a water soluble polymer, (ii) a positively charged carrier, and (iii) an adjuvant moiety, wherein when the cationic carrier unit is mixed with an anionic payload (e.g., an antisense oligonucleotide) that electrostatically interacts with the cationic carrier unit, the resulting composition self-organizes into a micelle encapsulating the anionic payload in its core. The cationic carrier units can also comprise a tissue specific targeting moiety, which would be displayed on the surface of the micelle. The disclosure also includes micelles comprising the cationic carrier units of the disclosure, methods of manufacture of cationic carrier units and micelles, pharmaceutical compositions comprising the micelles, and also methods of treating diseases or conditions comprising administering the micelles to a subject in need thereof. | 2022-08-18 |
20220257791 | METHODS FOR MAKING MULTILAYERED VESICLES - The disclosure relates to multilayered vesicles, methods for forming multilayered vesicles, and drug delivery complexes including multilayered vesicles. The multilayered vesicles can be formed by adding hydrophobe containing polypeptoid (HCP)-lipid complexes to unilamellar vesicles such as liposomes in an amount effective to form multilayered vesicles. The HCP-lipid complexes can be produced by mixing a hydrophobe containing polypeptoid (HCP) with a first set of unilamellar vesicles. The unilamellar vesicles and/or drug delivery complexes can include various cargoes for delivery, such as water-soluble cargoes, hydrophobic cargoes, etc. | 2022-08-18 |
20220257792 | COMPOSITIONS AND METHODS FOR MODULATING GENE OR GENE PRODUCT IN CELLS - Disclosed herein are methods for modulating an amount or activity of a gene or a gene product in a cell. The methods herein may comprise contacting a cell with a therapeutic agent assembled with a lipid composition, which lipid composition may comprise a dendrimer or dendron which may comprise one or more degradable diacyl group, in which may result in modulating the amount or activity of the gene or the gene product in the cell. The therapeutic agent modulating a gene or gene product in a cell may be sufficient to treat a disease or disorder in a subject. Further disclosed herein are pharmaceutical compositions, kits, and lipid compositions for modulating an amount or activity of a gene or a gene product in a cell. | 2022-08-18 |
20220257793 | COMPOSITIONS AND USE OF ENGINEERED MYOGENIC CELLS - Provided are compositions and methods of using engineered myogenic cells for delivery of an agent to an individual. Also provided are methods of producing reprogrammed myogenic cells from adult myogenic cells, and use of the reprogrammed myogenic cells for therapy and agent delivery. | 2022-08-18 |
20220257794 | CIRCULAR RNAS FOR CELLULAR THERAPY - This invention relates generally to pharmaceutical compositions and preparations of circular polyribonucleotides and uses thereof in cellular therapy. | 2022-08-18 |
20220257795 | MAKING AND USING IN VITRO-SYNTHESIZED ssRNA FOR INTRODUCING INTO MAMMALIAN CELLS TO INDUCE A BIOLOGICAL OR BIOCHEMICAL EFFECT - The present invention relates to compositions, kits and methods for making and using RNA compositions comprising in vitro-synthesized ssRNA inducing a biological or biochemical effect in a mammalian cell or organism into which the RNA composition is repeatedly or continuously introduced. In certain embodiments, the invention provides compositions and methods for changing the state of differentiation or phenotype of a human or other vertebrate cell. For example, the present invention provides mRNA and methods for reprogramming cells that exhibit a first differentiated state or phenotype to cells that exhibit a second differentiated state or phenotype, such as to reprogram human somatic cells to pluripotent stem cells. | 2022-08-18 |
20220257796 | RECOMBINANT AD35 VECTORS AND RELATED GENE THERAPY IMPROVEMENTS - The present disclosure provides, among other things, helper-dependent adenoviral serotype 35 (Ad35) vectors. In various embodiments, helper-dependent Ad35 vectors can be used to deliver a therapeutic payload to a subject in need thereof. Exemplary payloads can encode replacement proteins, antibodies, CARs, TCRs, small RNAs, and genome editing systems. In certain embodiments, a helper-dependent Ad35 vector is engineered for integration of a payload into a host cell genome. The present disclosure further includes methods of gene therapy that include administration of a helper-dependent Ad35 vector to a subject in need thereof. | 2022-08-18 |
20220257797 | COMPOUNDS, SYSTEMS, AND METHODS FOR MONITORING AND TREATING A SURFACE OF A SUBJECT - Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration. | 2022-08-18 |
20220257798 | H2O2-RESPONSIVE CROSSLINKING NEAR-INFRARED MOLECULAR PROBE FOR TUMOR MICROENVIRONMENT AND USE THEREFOR - The present invention discloses H | 2022-08-18 |
20220257799 | A RECEPTOR-TARGETING CONJUGATE WITH AN EFFECTIVE PHARMACOKINETIC PROFILE - The present invention describes a receptor-targeting conjugate comprising a fluorophore; a molecule, e.g. a peptide, binding to the receptor; and —a linker group which covalently links the fluorophore to the molecule binding to the receptor, wherein the conjugate is adapted to be administered intravenously into a human or animal body, and provide an effective pharmacokinetic profile with reference to inter alia receptor binding affinity and removal from plasma. | 2022-08-18 |
20220257800 | SELECTIVE DELIVERY MOLECULES AND METHODS OF USE - Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or tissue retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) cargo moieties (portion D | 2022-08-18 |
20220257801 | PARTICULATE STRUCTURES MADE FROM GOLD NANOPARTICLES, METHODS FOR PREPARING SAME AND USES THEREOF FOR TREATING SOLID TUMOURS - A particulate structure that includes a/ a biodegradable polymer particle, b/ gold nanoparticles covered on their surface with macrocyclic chelators complexing at least one ion of interest and/or a radionuclide for medical imaging, c/ a polycation having a positive charge over a pH range from 5 to 11, the gold nanoparticles b/ being encapsulated in the polymer particle a/ and/or adsorbed at the surface of the polymer particle a/. Also, a method for preparing the particulate structures. Further, the use of the particulate structures for radiotherapy or chemotherapy in the context of cancer treatment. | 2022-08-18 |
20220257802 | COMPRESSED SOLID COMPOSITION FOR MRI - The present invention relates to a compressed solid composition for MRI comprising a physiologically acceptable manganese (II) compound, its preparation and use for preparing an oral solution. | 2022-08-18 |
20220257803 | SUPERPARAMAGNETIC GOLD NANOPARTICLE CLUSTER-PROTEIN NANOPARTICLE FUSION BODY FOR MAGNETIC RESONANCE IMAGING AND MAGNETIC THERMOTHERAPY - The present invention relates to a superparamagnetic gold nanoparticle cluster-protein nanoparticle fusion body for magnetic resonance imaging and magnetic thermotherapy. According to the present invention, a superparamagnetic gold nanoparticle cluster-protein nanoparticle fusion body which has target directionality and a high density of ultrafine gold nanoparticles uniformly coupled to the surface of protein nanoparticles can be fabricated with neither a separate surface stabilization process nor a separate target directionality conferring process. Hence, the superparamagnetic gold nanoparticle cluster-protein nanoparticle fusion body according to the present invention is superior to conventional gold nanoparticles in terms of biocompatibility and has excellent target directionality as well as being identified to have a temperature elevation potential in an alternating magnetic field and a functionality as a T2-MRI contrast medium thanks to the superparamagnetism property of the ultrafine gold nanoparticles. | 2022-08-18 |
20220257804 | FILM-FORMING AGENT COMPOSITION FOR CONTRAST AGENT, FILM-FORMING LIPID SOLUTION FOR CONTRAST AGENT, CONTRAST AGENT AND PREPARATION METHOD THEREOF - Disclosed are a film-forming agent composition for contrast agent, a film-forming lipid solution including the film-forming agent composition, a contrast agent including the film-forming lipid solution, and a preparation method thereof. The film-forming agent composition for contrast agent includes a lipid, an emulsifier and a surface charge modifier; relative to 100 parts by weight of the lipid, the content of the emulsifier is 20-50 parts by weight, and the content of the surface charge modifier is 10-35 parts by weight; and the lipid is a carboxylated phospholipid, and the surface charge modifier is a polyelectrolyte. Based on the composition, the nanodroplets of the resulting contrast agent have more uniform particle size, higher stability and better controllability, as well as a lower threshold value for ultrasonic gasification. | 2022-08-18 |
20220257805 | PHARMACEUTICAL FORMULATIONS AND METHODS FOR DELIVERING A THERAPEUTIC, DIAGNOSTIC, OR IMAGING AGENT TO CD206 - The present disclosure provides pharmaceutical formulations and methods for delivering a therapeutic, diagnostic, or imaging agent to CD206. In an aspect, the present disclosure encompasses a pharmaceutical formulation for administration. The pharmaceutical formulation comprises a recombinantly produced intrinsic factor (IF), wherein the IF has a glycosylation pattern that enables binding to CD206. | 2022-08-18 |
20220257806 | FAR-UVC GERMICIDAL SYSTEM - A germicidal lighting system uses far-UVC lamps emitting frequencies that do not harm humans, for example 222 nm. The presence of a person is detected using sensors, and the far-UVC lamps are turned on when a person is present and off when no one is present. This may be applied to a person's whole body or, for example, a hand or hands. A far-UVC optical system for a germicidal lighting system may include a wavelength selective mirror arranged to receive far-UVC light from a far-UVC light source and to disproportionately reflect the far-UVC light in at least one wavelength of the far-UVC light relative to at least another wavelength of light emitted by the far-UVC light source. A far-UVC light source may be placed in a reflective enclosure to direct light through an opening. Facial recognition may be used to control the frequency a single person uses the system. | 2022-08-18 |
20220257807 | STERILIZATION UNIT AND METHODS OF USING THE SAME - A sterilization unit for sterilizing a product can include a body having an internal volume for receiving the product to be sterilized, and comprising at least one opening through which product can be introduced and/or withdrawn from the internal volume; a gas inlet in fluid communication with the internal volume for introducing one or more of an inert gas and a sterilizing gas into the internal volume during sterilization; a screen disposed in the gas inlet through which the one or more of the inert gas and the sterilizing gas must pass before entering into the internal volume; and a pressure release valve. The body can be capable of being pressurized to a pressure of 10 atm or more. | 2022-08-18 |
20220257808 | SELF-ADJUSTING DAMPER BASED LINEAR ALIGNMENT SYSTEM - A steam sterilizer having a door movable relative to an opening between a first open position and a second closed position. A plurality of spaced-apart roller assemblies are aligned along edges of the door to align the door relative to the opening as the door moves between the open and closed position. Each of the roller assemblies are comprised of a cylindrical roller having an outer annual recess extending along the periphery thereof. The recess is dimensioned to receive a lateral edge of the door. The roller is mounted on a shaft and is movable against a biasing force axially along the axis of the shaft. | 2022-08-18 |
20220257809 | POLYMER PACKAGING AND USE THEREOF FOR PRESERVING A PHARMACEUTICAL COMPOSITION - The present invention concerns packaging for preserving a sterile pharmaceutical composition, comprising at least an inner layer of polypropylene having a thickness of between 200 and 800 μm and an outer layer made from polyethylene, the outer layer being in contact with the environment and having a thickness of between 300 and 1000 μm. The invention also concerns a method for the sterile preservation of a pharmaceutical composition using such packaging. | 2022-08-18 |
20220257810 | SELF-SANITIZING TOUCHSCREEN COVER - An apparatus includes, among other components, a frame adapted to be connected to the exterior surface of a device that has a touchscreen. A retractable cover is operatively connected to the frame. The size of the retractable cover is equal to at least the size of the touchscreen, and the retractable cover is positioned to extend so as to cover the touchscreen. At least one ultraviolet light is also operatively connected to the frame. The ultraviolet light is positioned to direct ultraviolet lighting toward the touchscreen when the retractable cover extends to cover the touchscreen. | 2022-08-18 |
20220257811 | DISINFECTION DEVICE - An apparatus for disinfecting an object is disclosed herein. The apparatus includes an enclosure having an interior, an entrance, an exit, and a path through the interior from the entrance to the exit along which the object travels. The object moves along the path from the entrance to the exit without support from a moving conveyance. The apparatus also includes a light source that is positioned within the interior and configured to emit ultraviolet light such that every exterior surface of object is exposed to the ultraviolet light as the object traverses the interior. | 2022-08-18 |
20220257812 | PERSONAL MOBILITY DEVICE AND CONTROL METHOD THEREOF - A personal mobility device including handle grips coupled to both ends of a handle, a sterilization and drying unit disposed inside a frame of the handle and including an ultraviolet (UV) generator and a fan, and a controller configured to turn on the UV generator and the fan, based on the handle grips being positioned inside the frame. | 2022-08-18 |
20220257813 | PORTABLE ULTRAVIOLET DISINFECTOR - Embodiments of the present application disclose a handheld ultraviolet (UV) apparatus for surface disinfection. In one embodiment, the handheld UV apparatus includes a cabinet, a UV lamp, and a tapered reflector unit. The cabinet includes a side having an optical window. The UV lamp is mounted within the cabinet and proximate to the optical window, where the UV lamp is configured to provide UV light through the optical window. The tapered reflector unit includes a tapered reflector mounted within a housing. The tapered reflector unit includes a first open end, a second open end, and a lumen therebetween. The first open end is attached to the side for receiving the UV light. The first open end is larger than the second open end. The tapered reflector unit is adapted for directing the UV light through the lumen towards a target surface via the second open end. | 2022-08-18 |
20220257814 | Methods and Systems for Sterilizing Surgical Drains - Systems and methods for decontaminating a surgical drain and its reservoir are provided. An apparatus is provided in the form of a container having an interior chamber and an expansible opening to the interior chamber for insertion of a surgical drain therethrough. Ultraviolet light emitters are disposed within the interior chamber to emit beams of ultraviolet radiation at the surgical drain and/or its reservoir, thereby killing or neutralizing bacteria and fungus on the drain. Walls forming the expansible opening are collapsible to abut a portion of the inserted drain when inserted into the apparatus, and a fluid tight seal is formed between the drain and the apparatus. | 2022-08-18 |
20220257815 | STERILIZING SURGICAL INSTRUMENT TABLE - Embodiments of the disclosure include an uncovered ultraviolet light emitting panel for use in supporting instruments in an operating room. The panel fits inside an autoclave for sterilization and can be utilized without a sterile cover. In use, the panel irradiates surgical instruments and the nearby air continuously. | 2022-08-18 |
20220257816 | SELF-STERILIZING IV POLE SYSTEM - A system and method for sterilizing a wheelchair, stretcher or the like, that comprises an intravenous (IV) pole attaching to the wheelchair or stretcher having an electrical connector at the pole top, and a reflective drape having an interior lined with UV LED lights that electrically connects to the connector on top of the IV pole when draped over the wheelchair or stretcher. The UV LED lights sterilize the wheelchair or other equipment that is under the drape after a period of exposure to UV radiation without using disinfectant chemical sprays or wiping with disinfectant cloths and without staff attention. | 2022-08-18 |
20220257817 | DOOR HANDLE WITH DISINFECTANT FUNCTION - A door handle with a disinfectant function includes a liquid container containing a disinfectant liquid. The liquid container is embedded into an inner body of a door. The door handle with the disinfectant function enables to clean door handles used in public and private places such as hospitals, health care centers, public offices, schools, shopping malls, hotels, public transport, cafes and restaurants, and ensures the door handles are hygienic. | 2022-08-18 |
20220257818 | AUTONOMOUS MOBILE DISINFECTING AND DEODORIZING SYSTEM AND METHOD - The various embodiments of herein provide a system and a method for autonomous and contextual disinfection and deodorization of an environment. The system is also configured to provide a constant energy radiation of UV. The sweeping motors in the system enable covering maximum area for disinfection without moving the whole system. The system is configured with Ultraviolet (UV) radiation unit, which provides a constant radiation of energy for pre-set time duration. The UV radiation unit comprises a plurality of reflective mirror surfaces that are designed to rotate about their axis. The system is configured to identify, in real-time, the requirement of the disinfection and accordingly move to the location to disinfect and/or rotate the reflective mirror surfaces to enable effective disinfection of the environment. The system is also configured with ozone generator to provide deodorization of an environment. | 2022-08-18 |
20220257819 | CASH SANITIZATION OR STERLIZATION DEVICE - A cash sterilization device, includes a sterilization device case, the sterilization device case having an opening on one side and a cap assembly; an internal sterilization assembly, the internal sterilization device including an opening, wherein the internal sterilization is inserted into the opening of the sterilization device case, the cap assembly is attached to cover the internal sterilization within the sterilization device case, and wherein the opening of the sterilization device case is aligned with the opening of the internal sterilization assembly. | 2022-08-18 |
20220257820 | METHOD FOR DETERMINING THE EFFECTIVENESS OF A STERILIZATION METHOD FOR A MEDICAL PRODUCT IN A STERILIZER, DATA PROCESSING SYSTEM, COMPUTER PROGRAM PRODUCT, AND MEDICAL PRODUCT - A process is presented for determining the effectiveness of sterilizing processes for medical devices with the following steps: providing a data structure, wherein the data structure represents a grid formed of a plurality of three-dimensional cells; recreating the medical device arranged in the sterilizer in the data structure in such a way that a first multiplicity of cells of the grid represent a body of the medical device and that a second multiplicity of cells represent an interior of the sterilizer which is not occupied by the body of the medical device; recreating an initial state in the data structure in such a way that each cell of the second multiplicity of cells is assigned data relating to the temperature prevailing at the location of the cell, the quantity of a first medium located in the area of the cell, and the quantity of a second medium located in the area of the cell; recreating, step by step, changes in the temperature, in the quantity of the first medium and in the quantity of the second medium occurring in each cell of the second multiplicity of cells during the sterilization process; and calculating a reduction in a germ loading achieved in each cell of the second multiplicity of cells during the sterilization process taking into consideration the prevailing temperature, quantity of the first medium and quantity of the second medium in the respective cell in each step. Furthermore, a data processing system and a computer program product for carrying out the process are presented. | 2022-08-18 |
20220257821 | STERILE INDICATOR POUCH - A sterilization pouch that includes a perimeter, a first end, a second end, a length extending from the first end to the second end, a first side, a second side, a width extending from the first side to the second side, a first layer, a second layer bonded to the first layer along a portion of the perimeter to define a pouch having an opening and an interior space for receiving an article therein, a first interior sterilization indicator that changes from a first color state to a second color state when exposed to a sterilization condition, the first interior sterilization indicator being disposed between the first layer and the second layer, being disposed along a major portion of the length of the pouch, being disposed along a major portion of the width of the pouch, or being disposed along both a major portion of the length of the pouch and along a major portion of the width of the pouch, the sterilization indicator being visible through the first layer. | 2022-08-18 |
20220257822 | AIRBORNE VIRUS PROTECTION AND DISINFECTION DEVICE AND METHOD OF MANUFACTURING - An airborne virus protection and disinfection (AIRVPD) device includes positive and negative electrodes arranged to form an electrode fluid path therebetween and a high-voltage converter configured to deliver power to the positive and negative electrodes to trigger a redox reaction. The AIRVPD device also includes a chemical disinfecting unit having a sponge material associated with at least one of the positive and negative electrodes and capable of becoming impregnated with an antimicrobial capable of killing airborne viruses. The AIRVPD device further includes a housing encasing the positive and negative electrodes, the high-voltage converter, and the chemical disinfecting unit. The housing includes an inlet and an outlet in fluid communication with each other via the electrode fluid path. Ionized air with charged droplets external to the AIRVPD device is able to flow through the AIRVPD device for disinfection and neutralization. | 2022-08-18 |
20220257823 | METHOD FOR STERILIZING AND DECONTAMINATING POST-CONSUMER ABSORBENT SANITARY PRODUCTS POLLUTED WITH ORGANIC COMPOUNDS DERIVED FROM HUMAN METABOLISM - A method for sterilizing and decontaminating post-consumer absorbent products polluted with organic compounds derived from human metabolism including drug residues, the post-consumer absorbent sanitary products comprising fractions of plastic, super-absorbent polymers (SAP), and optionally cellulose, the method including at least the steps of: sterilizing (SR) the absorbent sanitary post-consumer products by heating to a temperature equal to or less than 140° C., and to a pressure lower than 4 bar, decontaminating (DC) the post-consumer absorbent sanitary products of organic compounds by treating with an oxidizing composition comprising at least one compound selected from the group consisting of hydrogen peroxide, sodium percarbonate, potassium percarbonate, sodium perborate, potassium perborate, potassium monopersulfate, ammonium persulfate, sodium persulfate, potassium persulfate, and ozone. The at least one compound is contained in the oxidizing composition in an amount equal to or greater than 2% by weight with respect to the dry weight of the post-consumer absorbent sanitary products. | 2022-08-18 |
20220257824 | Custom Molded Textile - An orthopedic precast comprises a knitted shell portion and a knitted flexible portion. The precast is positioned about a limb or other mold, and heat or other hardening agent is used to harden the shell portion, while retaining flexibility in the flexible portion. Contemplated hardening agents include light, heat, and chemical polymerizing agents. In some embodiments the shell portion includes threads or yarns comprising a thermoplastic, which is then hardened by heating the thermoplastic sufficiently to at least partially melt, and thereby fuse together some of the threads or yarns, and then cooling to ambient temperature. In other embodiments, the precast is contained in a bag or other airtight container, along with a self-heating composition that is triggered to release heat upon contact with oxygen. In still other embodiments, the precast includes a prepolymer of other polymerizable composition, which is polymerized by effective application of light, heat, and/or chemical agent(s). | 2022-08-18 |
20220257825 | USE OF SELF-ASSEMBLING POLYPEPTIDES AS TISSUE ADHESIVES - The present invention relates to a self-assembling polypeptide for use as tissue adhesive. The present invention also relates to the use of a self-assembling polypeptide as tissue adhesive. Further, the invention is directed to the use of a self-assembling polypeptide to glue one or more cosmetic compounds on skin, mucosa, and/or hair. Furthermore, the invention is directed to a self-assembling polypeptide for use in gluing one or more pharmaceutical compounds on tissue, skin, mucosa, and/or hair. | 2022-08-18 |
20220257826 | METHOD OF TREATING LOWER BACK PAIN - The present invention provides relatively non-invasive treatments generally involving injection of a treatment composition to a subject's target site which exhibits a defined degradation state (e.g. typically “partially-degraded target sites”) and/or symptoms corresponding with such a degradation state. Such target sites, which are suitably specific regions of a human or animal body (e.g. an intervertebral disc or a component part thereof, such a nucleus pulposus), typically degrade to the defined degradation state as a consequence of biological degeneration at the target site, in particular cellular and/or extracellular degradation, and administration thereto of treatment compositions of the invention can facilitate physical and/or biochemical restoration of such target sites. | 2022-08-18 |
20220257827 | ADDITIVE MANUFACTURING OF VINYL, PHOTOCROSSLINKABLE POLYMERS - Various precursor solutions and methods of 3D printing and other additive manufacturing approaches are provided for the manufacture of articles using photocrosslinkable vinyl shape memory polymers. In various aspects, articles are manufactured by a process comprising (i) exposing a precursor solution to an intensity and frequency of light to initiate photo-polymerization of the precursor solution to form a layer of the article; and (ii) repeating step (i) a number of times to form the article in a layer-by-layer approach; wherein the precursor solution comprises a first polymeric precursor comprising a plurality of vinyl terminated side-chains attached thereto. A vinyl-functionalized, photocrosslinkable SMP used as an example herein is a novel variant of a previously disclosed SMP composition, with higher amounts of vinyl functionalization but similar thermomechanical properties to the SMP library previously disclosed. Moreover, a unique combination of chemistries is disclosed that incorporates the aforementioned vinyl-functionalized SMPs along with acrylate-based crosslinkers. Additional novel compositions are disclosed containing the vinyl-functionalized SMPs with additional dithiol functionalizations, vinyl-functionalized SMPs with dithiol crosslinkers, as well as vinyl-functionalized SMPs with both acrylate-based and dithiol crosslinkers, as another means to tune degradation rates and other material properties. The articles can include a variety of articles such as stents, grafts, external sheaths, and the like. Beneficially, the printed articles can include a plurality of pores having an average diameter of about 50 pm to about 5000 pm, about 500 pm to about 2000 pm, or about 1000 pm even in the absence of a photoblocker. | 2022-08-18 |
20220257828 | TUNABLE, CONTROLLED-RELEASE, URETHANE-CONTAINING ELASTOMERS AND PROCESSES OF FORMING THE SAME - A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25. | 2022-08-18 |
20220257829 | COMPOSITIONS AND METHODS FOR PREVENTING ALLERGIES - Disclosed are compositions derived from non-primate mammals having reduced expression of alpha 1,3 gal and their use in food products, food additives, cosmetic products, cosmetic additives, medical products, medical devices and products used in research and production of therapeutics. The compositions and methods disclosed are particularly useful to subjects diagnosed with α-Gal Syndrome (AGS). | 2022-08-18 |
20220257830 | RIGID RESORBABLE MATERIALS WITH POLYMER AND ORGANIC FILLERS - This invention relates to the composition of flexible resorbable polymers with rigid resorbable fillers. The invention further relates to processing of flexible resorbable polymers with rigid resorbable fillers. The invention relates also to the use of such materials for applications in fast degradation applications. The invention also relates to the composition of flexible resorbable polymers with rigid resorbable for making shape memory materials. This invention also related to the processing of such materials by extrusion, injection molding, thermoforming, solvent mixing, and additive manufacturing. The invention also relates to the use of such materials as bone filler, vascular closure and other hemostasis devices, aneurysms, and stent applications. The invention also relates to the use of such materials as drug delivery platforms. | 2022-08-18 |
20220257831 | METHOD AND DEVICE FOR IN VIVO BRONCHUS REGENERATION - Aspects of the disclosure relate methods and synthetic scaffolds for regenerating hollow tubular organs present in the respiratory system such as bronchus tissue. | 2022-08-18 |
20220257832 | COMPOSITIONS COMPRISING COATED CERAMIC PARTICLES AND METHODS OF MAKING THEM - A bone implant is provided which includes a plurality of lyophilized porous macroparticles comprising ceramic material and collagen. The plurality of lyophilized porous macroparticles is coated with a mineral coating which comprises nano-size features having a carbonate-substituted, calcium-deficient hydroxyapatite component, the bone implant comprising a plurality of recesses, projections, or a combination thereof. A method of making the bone implant and a method of treating a bone defect with the bone implant are also provided. | 2022-08-18 |
20220257833 | CULTURED CELL SHEET FOR TISSUE REGENERATION, PRODUCTION METHOD THEREOF, AND APPLICATION METHOD THEREOF - Provided is a cell sheet suitable for cartilage repair. The present invention provides a cell sheet for cartilage repair, formed from a culture of cells derived from a cartilage tissue, and the cell sheet is negative for immunostaining using an antibody against type II collagen. The present invention also provides a method for producing a cell sheet for cartilage repair, formed from a culture of cells derived from a cartilage tissue, and the method includes culturing cells derived from a cartilage tissue on a surface of a membrane, where a temperature-responsive polymer is immobilized on the surface, to give the cell sheet. The culturing is stopped before the cell sheet becomes positive for immunostaining using an antibody against type II collagen. | 2022-08-18 |
20220257834 | Aortic Stent - The invention relates to a stent for placement at an aortic annulus that is expandable from an undeployed state to a deployed state comprising a stent frame having rows of cells with a proximal section and a distal section at a longitudinal axis of the stent, the stent frame being formed by a plurality of arms, the arms being connected to one another at connection points, and wherein the plurality of arms forms a plurality of diamond-shaped stent cells, in particular the rows of cells, formed of vertices at said connection points between the arms, a dry valve made out bovine pericardium arranged at least at the distal section of the stent with the dry bovine pericardium being configured to be rehydrated with a solution, a skirt surrounding the dry valve and comprising at least one of bovine pericardium and polyester, and one or more eyelets arranged at a distal end of some of the arms, with the eyelets being configured to fix the valve to the stent frame. | 2022-08-18 |
20220257835 | SELF-EXTENDABLE STENT FOR PULMONARY ARTERY - The invention relates to a self-expandable stent, especially a pulmonary stent, with a proximal section, a middle section and a distal section arranged at a longitudinal axis of the stent, the stent having a dry valve made of bovine pericardium arranged at the middle section thereof, a skirt surrounding the dry valve at least at the middle section and made of one of bovine pericardium and polyester, wherein the stent further comprises eyelets arranged at a distal end at the distal section and/or a proximal end at the proximal section for fixing the stent at an artery, and wherein the stent comprises a frame composed of a plurality of arms forming the proximal, the middle and the distal section with the sections being interconnected, and the stent comprising a fixture area at the middle section of the frame with the arms being arranged in parallel to each other at the fixture area and the middle section comprising one or more fixture openings at said fixture area for fixing the valve at the frame. The invention further relates to A delivery device for delivering a self-expandable stent according to claims | 2022-08-18 |
20220257836 | BIOLOGIC FILLER FOR RESTORING AND REGENERATING TISSUE - Compositions and methods for filling tissue voids and defects with a self-assembling biopolymer configured to form a shape-retaining matrix are described. | 2022-08-18 |
20220257837 | Means and methods for providing a substrate with a biocidal coating, and coated substrates obtainable thereby - The invention relates to the field of antimicrobial materials, in particular to implantable and other medical devices, exhibiting antimicrobial activity. Provided is a method for providing a substrate with an antimicrobial coating comprising providing a substrate that is coated with a polyamine-functionalized polymer, and contacting said polyamine-functionalized polymer with an aqueous salt solution comprising at least one salt having a polarizability α | 2022-08-18 |
20220257838 | BIOABSORBABLE FLOW DIVERTING SCAFFOLD AND METHODS FOR ITS USE - This disclosure relates to scaffolds made of a braid of bioabsorbable polymeric fibers for implantation within a lumen of a mammalian body and, in particular, to such scaffolds that are configured to divert blood flow from a pathology associated with a blood vessel. | 2022-08-18 |
20220257839 | METHODS, COMPOSITIONS AND KITS FOR SURGICAL REPAIR - In some aspects, the present invention provides surgical procedures that comprise applying compositions into and/or onto tissue, including supporting tissues (e.g., ligaments, connective tissue, muscles, etc.) for pelvic organs, among other tissues. In other aspects, the present disclosure pertains to compositions that are useful for performing such procedures. In still other aspects, the present disclosure pertains to kits that are useful for performing such procedures. | 2022-08-18 |
20220257840 | BLOOD PROCESSING FILTER - A blood processing filter includes a flexible container having an inlet and an outlet for blood, a filter medium disposed between the inlet and the outlet, and a flow passage-securing member disposed between the filter medium and the outlet. The filter medium includes a filter layer X | 2022-08-18 |
20220257841 | Centrifuge Device and Method of Use - A portable centrifuge comprising a base, which includes a rotational mechanism contained within. A sequester wheel having a plurality of concentric rings, forming at least one channel and a central container. The at least one channel comprising a second volume and the central container comprising a first volume. A first cover is disposed over the sequester wheel to create a seal. A second cover is disposed over the first cover and is rotatable to engage with the rotational mechanism to initiate rotation at a predetermined RPM. The whole blood and/or other tissue is separated into its constituent components and deposited into the at least one channel and the central container. Specific volumes of the constituent components may be calculated to match or substantially match the first and second volumes for predetermined volume control and ease of access. | 2022-08-18 |
20220257842 | DIALYSIS MACHINE AND METHOD OF OPERATING A BALANCING CHAMBER SYSTEM OF A DIALYSIS MACHINE - The present invention relates to a dialysis machine having a dialyzer and having a first balancing chamber and having a second balancing chamber, wherein the first inflows of the first balancing chamber halves are in fluid communication with a source of fresh dialyzate and the first outflows of the first balancing chamber halves are in fluid communication with a dialyzer inflow, and wherein the second inflows of the second balancing chamber halves are in fluid communication with a dialyzer outflow and the second outflows of the second balancing chamber halves are in fluid communication with a drain, wherein a third balancing chamber is provided that has two balancing chamber halves that are separated from one another by a movable wall, wherein each of the balancing chamber halves has a respective inflow and a respective outflow that are each provided with valves that are configured to close or open the respective inflow or outflow, wherein the two inflows are in fluid communication with a source of fresh dialyzate, and wherein the two outflows are in fluid communication with the dialyzer inflow. | 2022-08-18 |
20220257843 | FORMULATIONS AND METHODS FOR DIRECT SODIUM REMOVAL IN PATIENTS HAVING SEVERE RENAL DYSFUNCTION - A direct sodium removal (“DSR”) infusate regimen and methods of use are provided for removing sodium and reducing fluid overload in patients with severe renal dysfunction and/or heart failure, in which a patient has at least a first DSR session with a first DSR infusate having no or low sodium that is instilled into a patient's peritoneal cavity for a first dwell period to cause sodium and excess fluid to migrate to the patient's peritoneal cavity, and thereafter, the patient may undergo conventional dialysis to rebalance the patient's fluid and sodium levels. | 2022-08-18 |
20220257844 | RED BLOOD CELLS FOR DRUG DELIVERY - It is an object of the present invention a method to introduce compounds inside red blood cells comprising: —providing red blood cells from a subject; —providing one or more compounds to be encapsulated in said red blood cells; —providing a loading device comprising a microporous matrix; —feeding said loading device with a suspension comprising said red blood cells and said one or more compounds; —collecting the red blood cells exiting from said loading device, which are encapsulated red blood cells; characterized in that: —said red blood cells and said one or more compound are in suspension at a pH of between 6.8 and 7.8, preferably of between 7.35 and 7.45; —the pores in said microporous matrix have a minimum size of at least 3 times the size of a red blood cell, that is a minimum size of at least 20 μm; —the pores in said microporous matrix have an average size of between 30 and 500 μm, or of between 40 and 400 μm, or of between 50 and 350 μm, or of between 100 and 250 μm; —said porous matrix has a length L of at least 1 mm and a width W and a height H such that it comprises at least one unit cell, said unit cell being equal to the microporous matrix volume that, repeated by rototranslation through the vectors that generate the matrix, fills the whole matrix itself; wherein said loading device is fed with said suspension in such a way to obtain an average fluid speed of between 10 | 2022-08-18 |
20220257845 | DUAL LUMEN CANNULA SYSTEM - Systems and methods for providing oxygenated blood to a patient, e.g., in a patient with inadequate or failing circulation, including a dual lumen cannula system for drawing blood from the heart and returning oxygenated blood therein. Methods may feature inserting the dual lumen cannula system through the left ventricle such that intake aperture are positioned entirely within the left ventricle and the tip of the cannula is positioned in the aorta of the patients heart. By fluidly connecting the cannula to a cardiac assistance device, deoxygenated blood may be drained from the left ventricle through the intake apertures and oxygenated blood may be pumped into the aorta thorough the tip. | 2022-08-18 |
20220257846 | EXTRACORPOREAL BLOOD DISINFECTION SYSTEMS AND METHODS - Selective extracorporeal blood disinfection systems and related methods are disclosed. The systems comprise an input tube forming a flowpath for the flow of infected blood. The systems further comprise a disinfection unit comprising a microbicidal light emitting device configured to emit visible light within the range of about 380-425 nm and/or about 500-700 nm, and a treatment flowpath in communication with the input tube that is substantially transparent to the emitted light of the microbicidal light emitting device for receiving at least a portion of the flow of the infected blood therethrough. The microbicidal light emitting device effectuates a dose of the emitted light to the infected blood flowing through the treatment flowpath to disinfect the blood. The systems also comprise an output tube in fluid communication with the treatment flowpath forming a flowpath for the flow of the disinfected blood from the disinfection unit. | 2022-08-18 |
20220257847 | IRRIGATION AND ASPIRATION DEVICE AND METHOD - Irrigation and/or aspiration devices and methods may be configured to aspirate and irrigate alone, sequentially, or concurrently. The devices and methods may provide a base with a removable head, and adapted for partial or complete separation of the irrigation and aspiration functions. The devices and methods can be configured to aspirate and/or irrigate the nasal and sinus cavities. The devices and methods may be manually and/or automatically controlled. The devices and methods may include removable, and/or replaceable, and/or refillable, and easily cleanable reservoirs for aspirant and irrigant. The device head and/or aspirant reservoir may comprise a diagnostic device, i.e., test device and/or container after use of the devices and methods. | 2022-08-18 |
20220257848 | MOTOR-DRIVEN MEDICAL SUCTION PUMP - The present invention relates to a motor-driven medical suction pump with a pump unit for generating a negative pressure with a housing which accommodates the pump unit therein, wherein the pump unit comprises a vacuum opening for the negative pressure to be generated by the pump unit and at least one further opening communicating with the vacuum opening through the pump unit. The present invention indicates a suction pump of the type mentioned above which is easy to produce, compact in design and provided with good sound damping properties and which for this purpose comprises a sound damping chamber which is tightly connected to and encloses the further opening. | 2022-08-18 |
20220257849 | SYSTEMS AND METHODS FOR MECHANICAL DISPLACEMENT OF AN ESOPHAGUS - An example assembly for use with a vacuum system and an esophageal positioning device esophageal positioning device includes an introducer, in which the esophageal positioning device includes a handle, a first segment, a second segment and an articulation driving mechanism. The first segment being coupled to the handle. The second segment being pivotally connected to the first segment. The articulation driving mechanism being configured to pivot the second segment about the first segment upon articulation. | 2022-08-18 |
20220257850 | Negative-Pressure Dressing For Foot Treatment - Disclosed dressing embodiments may include a tissue interface and a cover, with the tissue interface shaped anatomically for interaction with a specific anatomical region, such as a foot. Such tissue interface embodiments would typically comprise a manifold and a fluid control layer having a plurality of fluid restrictions, with the manifold disposed in a stacked relationship with the fluid control layer. Some embodiments of the tissue interface might also include a gel layer in a stacked relationship with the fluid control layer, opposite the manifold. For foot dressings, tissue interface embodiments may be shaped with a hindfoot section, an underfoot section, and a forefoot extension section. | 2022-08-18 |
20220257851 | SENSOR SHEET WITH DIGITAL DISTRIBUTED DATA ACQUISITION FOR WOUND MONITORING AND TREATMENT - A wound monitoring and/or therapy apparatus can include multiple sensor circuits, a selection circuit coupled to each sensor circuit, and a processor configured to be in communication with the selection circuit. Each sensor circuit can process multiple sensor signals to generate a single output signal from the multiple sensor signals. Each of the sensor signals can correspond to a measurement of a sensor positioned on a substrate that is configured to be positioned at least partially in a wound. The selection circuit can receive the single output signals from the sensor circuits and outputs a selected single output signal. The processor can receive the selected single output signal and decomposes the selected signal output signal into the multiple sensor signals used to generate the selected single output signal. The processor can activate sensors and receive sensor data from the sensors. The processor can digitize the sensor data and transmit the digitized sensor data to a remote controller. | 2022-08-18 |
20220257852 | ANALYTICAL METHOD FOR CONTROLLED AND MEASURED INTERNAL FLUID AFTER SURGERY - A system and apparatus for the collection of serous or serosanguinous fluid from a percutaneous site after surgery. A pump unit with one or more pumps or powered sources provide continuous negative pressure suction to draw fluid from the percutaneous site and pumps the fluid into disposable reservoirs with one-way valves that are easy to handle while maintaining sterility and a seal to prevent the loss of vacuum. Air is continuously removed from the reservoirs. Measurement and analysis of the output is performed automatically. Additionally, through such a peristaltic pump device, controlled collection of measured surgical and/or bodily fluid from a subject patient may be undertaken allowing for more effective and closer analysis, as well. | 2022-08-18 |
20220257853 | INFUSION SYSTEM AND COMPONENTS THEREOF - Certain embodiments provide multi-medicament infusion systems for preventing the cross-channeling of medicaments. The system may include one or more of an infusion pump, medicament cartridges, cartridge connectors, a multi-channel fluid conduit, and an infusion set. The infusion pump can have an inductively chargeable battery assembly that can be charged by an inductive charging pad. | 2022-08-18 |
20220257854 | IMPLANTABLE MICROSPHERE RESERVOIR - A drug delivery system including an implantable reservoir containing drug microspheres, with an innocuous fluid flushed through the implantable microsphere reservoir to form a drug containing solution for delivery within a body of a patient. | 2022-08-18 |
20220257855 | SELF-ACTUATING ARTICLES - Self-actuating articles including, for example, self-actuating needles and/or self-actuating biopsy punches, are generally provided. Advantageously, the self-actuating articles described herein may be useful as a general platform for delivery of a wide variety of pharmaceutical drugs that are typically delivered via injection directly into tissue due to degradation in the GI tract. The self-actuating articles described herein may also be used to deliver sensors and/or take biopsies without the need for an endoscopy. In some embodiments, the article comprises a spring (e.g., a coil spring, a beam, a material having particular mechanical recovery characteristics). Those of ordinary skill in the art would understand that the term spring is not intended to be limited to coil springs, but generally encompass any reversibly compressive material and/or component which, after releasing an applied compressive force on the material/component, the material/component substantially returns to an uncompressed length of the material/component (e.g., the within 95% of the length of the material/component prior to compression). | 2022-08-18 |
20220257856 | DRUG SOLUTION INJECTION CONTROLLER - A drug solution injection controller | 2022-08-18 |
20220257857 | EVENT-TRIGGERED MODEL PREDICTIVE CONTROL FOR EMBEDDED ARTIFICIAL PANCREAS SYSTEMS - The development of artificial pancreas (AP) technology for deployment in low-energy, embedded devices is contingent upon selecting an efficient control algorithm for regulating glucose in people with type 1 diabetes mellitus (T1DM). The energy consumption of the AP can be lowered by reducing updates of the control model: the number of times the decisionmaking algorithm is invoked to compute an appropriate insulin dose. | 2022-08-18 |
20220257858 | AUTOMATED SUPER BOLUS GENERATION - Techniques related to automatically generating a super bolus may include determining an amount of an augmented meal bolus to be delivered to a patient for regulating the patient's glycemic response to a meal. The amount of the augmented meal bolus may exceed a sufficient amount for counteracting a glucose level increase caused by the meal. In some embodiments, the techniques may further include determining a duration of a postprandial reduction period during which basal dosage deliveries to the patient are to be reduced. In some other embodiments, the techniques may further include delivering the augmented meal bolus to the patient prior to determining whether or not to cause reduction of basal dosage deliveries. More specifically, a glucose level of the patient may be obtained after delivery of the augmented meal bolus, and the obtained glucose level may be used to determine whether to reduce basal dosage deliveries. | 2022-08-18 |
20220257859 | DYNAMIC SUPER BOLUS GENERATION - Techniques related to automatically generating a super bolus may include determining an amount of an augmented meal bolus to be delivered to a patient for regulating the patient's glycemic response to a meal. The amount of the augmented meal bolus may exceed a sufficient amount for counteracting a glucose level increase caused by the meal. In some embodiments, the techniques may further include determining a duration of a postprandial reduction period during which basal dosage deliveries to the patient are to be reduced. In some other embodiments, the techniques may further include delivering the augmented meal bolus to the patient prior to determining whether or not to cause reduction of basal dosage deliveries. More specifically, a glucose level of the patient may be obtained after delivery of the augmented meal bolus, and the obtained glucose level may be used to determine whether to reduce basal dosage deliveries. | 2022-08-18 |
20220257860 | MEDICAMENT PUMPS AND CONTROL SYSTEMS FOR MANAGING GLUCOSE CONTROL THERAPY DATA OF A SUBJECT - Glucose control systems are disclosed. An ambulatory medicament pump that is configured to wirelessly transmit one or more of a plurality of glucose control parameters and glucose control therapy data to a second ambulatory medicament pump is disclosed. A control system for transferring historical pump data from a first ambulatory medicament pump to a second ambulatory medicament pump is also disclosed. The control system can receive the historical pump data from a first ambulatory medicament pump, determine that at least one of a plurality of pairing conditions is satisfied to connect the data interface to the second ambulatory medicament pump, transmit, via the data interface, a pairing signal to the second ambulatory medicament pump, and transmit at least one of the therapy data associated with the delivery of the glucose control therapy or the glucose control parameter. | 2022-08-18 |
20220257861 | DEVICE FOR TREATING AN INDIVUDUAL SUFFERING FROM CARDIAC INSUFFICIENCY, CARDIAC ARREST, CIRCULATORY ARREST OR STROKE - The invention relates to a device for treating an individual suffering from cardiac or circulatory arrest or from a stroke, comprising a blood withdrawal device (BE) that is applied to the individual (P), an analysis unit (BA) which is directly or indirectly connected to the blood withdrawal device for detecting a blood analysis result (BAE) providing at least one characteristic of the blood, directly or indirectly connected to a blood return device (BR) that is applied to the individual (P) and is designed to deliver a substance to the individual via the return device (BR). | 2022-08-18 |
20220257862 | CONTROLLABLE DRUG DELIVERY SYSTEM AND METHOD OF USE - A drug delivery system is disclosed that includes a drug delivery device having a reservoir, a delivery cannula having a proximal end in fluid communication with the reservoir and a distal end to be received within a patient, and one or more controllable elements. The drug delivery system may further include one or more sensors coupled to the drug delivery device, and a controller coupled to the one or more sensors and the one or more controllable elements. The controller may be configured to use the one or more sensors to determine a condition or an operational state of the drug delivery device. Furthermore, the controller may be configured to control the controllable element based on the condition or the operational state of the drug delivery device and/or identity information stored in a memory onboard the device. A method for use with a drug delivery device is also disclosed. | 2022-08-18 |
20220257863 | EXTERNALLY POWERED SYRINGE DRIVERS AND SYSTEMS AND METHODS FOR USING THEM - Syringe drivers and injector devices are provided. The driver includes a housing including a port communicating with a gas chamber therein and connectable to an external air source, and a cavity that receives a syringe containing an agent. A drive piston within the housing includes a first end disposed adjacent the gas chamber and a second end including a plunger connectable to the syringe. A damping mechanism is provided within that housing that is coupled to the drive piston that includes a damper piston within a damping fluid chamber such that, when the drive piston is advanced by gas delivered into the gas chamber from the external source to deliver the agent from the syringe, damping fluid within the damping fluid chamber flows through an orifice or valve from a first region to the second region, thereby limiting movement of the drive piston. | 2022-08-18 |
20220257864 | AUTOINJECTOR WITH STALL AND END POINT DETECTION - An autoinjector drug delivery device configured with a stall and endpoint detection algorithm is described that allows for variations in the fill of the drug, barrel, plunger, and other components. The stall or end point detection can cause the autoinjector to stop an extrusion process. | 2022-08-18 |
20220257865 | AUDIBLE INDICATOR FOR A DRUG DELIVERY DEVICE - The disclosure relates to a drug delivery device, comprising a mechanical audible indicator capable of producing an audible signal with a volume of at least 100 dB. | 2022-08-18 |