34th week of 2008 patent applcation highlights part 46 |
Patent application number | Title | Published |
20080200645 | Methods for Treatment or Prophylaxis of Atherosclerosis and Reperfusion Injury - The invention provides the use of a complement inhibitor in the preparation of a medicament for the treatment or prophylaxis of atherosclerosis in a subject in need of treatment by administering to the subject a therapeutically effective amount of said medicament. The complement inhibitor may be a molecule which can inhibit activation of at least one complement component, inhibit activity of at least one activated complement component, act as an antagonist against at least one complement receptor, or combinations thereof. | 2008-08-21 |
20080200646 | PREVENTION AND REDUCTION OF BLOOD LOSS - Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting and other surgical procedures, especially when such procedures involve extra-corporeal circulation, such as cardiopulmonary bypass. | 2008-08-21 |
20080200647 | On-Resin Peptide Cyclization - Method of peptide synthesis, comprising the steps of a. synthesizing a peptide linked to a solid phase which peptide comprises at least one cysteine, homo- or nor-cysteine residue, which cysteine is protected in its side chain by a S-tert.butyl-sulphenyl group b. either coupling N-terminally a further amino acid having a 3,3′-dithio-(1-carboxy-propyl)-propionyl-radical on its Nα or deprotecting the Nα of the N-terminal amino acid and reacting the free Nα with 3,3′-dithio-propionic acid imide to yield the corresponding Nα-3,3′-dithio-(1-carboxy-propyl)-propionamide or deprotecting the Nα of the N-terminal amino acid and reacting the free Nα with a compound of formula IV R7-S—S—[CH | 2008-08-21 |
20080200648 | Method of Peptide Synthesis - A novel for amidation of C-terminal carboxyl groups of peptides is devised, which methods avoids undesired epimerisation of the α-carbon of the C-terminal amino acid yielding diastereoisomeric variants of the amidated peptide. | 2008-08-21 |
20080200649 | Method - A method for optimised refolding of a protein which method comprises selecting for the protein at least three control factors which affect refolding of the protein and at least three levels for each control factor, making a Taguchi matrix of the control factors and levels, conducting experiments as required by the matrix, and refolding the protein in a process using the control factors at levels determined by the outcomes of the matrix experiments. | 2008-08-21 |
20080200650 | Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use - The present invention provides isolated polypeptides isolatable from a | 2008-08-21 |
20080200651 | Selective Reduction and Derivatization of Engineered Proteins Comprising at Least One Non-Native Cysteine - The present invention relates to method for selective reduction and derivatization of recombinantly prepared engineered proteins comprising at least one non-native cysteine, wherein the reduction reaction is conducted in the presence of a redox buffer or in the presence of a triarylphosphine reducing agent. | 2008-08-21 |
20080200652 | Novel Cherkasky fusion proteins containing antibody binding proteins or the regions thereof - Disclosed are novel fusion proteins containing antibody binding regions and certain other regions. Said fusion proteins can form complexes with antibodies, which can thus be modified and be arranged three-dimensionally. Furthermore, the effect thereof can be boosted. | 2008-08-21 |
20080200653 | COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR - The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. | 2008-08-21 |
20080200654 | ANTI-A33 ANTIBODY - The present invention provides: an antibody or a antibody fragment thereof, which can bind to A33, which specifically attacks A33-expressing tumor cells with the use of ADCC and CDC based on the immune system, and for which no HAHA is produced; and a preventive or therapeutic agent for various malignant tumors including solid tumors that are currently treated with difficulty, which contains the antibody or an antibody fragment thereof. Specifically, the antibody or a functional fragment thereof is capable of binding to A33 and is produced by a hybridoma M10 (accession No. FERM BP-10107), M96 (accession No. FERM BP-10108), M165 (accession No. FERM BP-10106), N26 (accession No. FERM BP-10109), Q47 (accession No. FERM BP-10104), Q54 (accession No. FERM BP-10105), or R5 (accession No. FERM BP-10107). The preventive or therapeutic agent for tumors contains the antibody or a functional fragment thereof. | 2008-08-21 |
20080200655 | Protein Formulations Containing Sorbitol - The present invention provides a method for suppressing protein aggregation in a liquid formulation during freeze-thaw by including sorbitol in the liquid formulation. The present invention also provides methods for storing and preparing a liquid formulation containing a protein and sorbitol such that the presence of sorbitol suppresses protein aggregation during freezing and/or thawing. | 2008-08-21 |
20080200656 | Use Of Sucrose To Suppress Mannitol-Induced Protein Aggregation - The present invention provides a method for suppressing mannitol-induced protein aggregation by providing sucrose to a liquid formulation containing a protein. The present invention also provides methods for storing and preparing a liquid formulation containing a protein and a combination of mannitol and sucrose such that the presence of sucrose suppresses mannitol-induced protein aggregation. | 2008-08-21 |
20080200657 | Mutant of Granulocyte-Colony Stimulating Factor (G-Csf) and Chemically Conjugated Polypeptide Thereof - Provided are mutants of human granulocyte-colony stimulating factor (G-CSF) designed for specific chemical conjugation, and chemical conjugates thereof for use as an adjuvant in the treatment of cancer. The present invention provides a mutant of a G-CSF in which a threonine (Thr) residue at position 133 of G-CSF comprising the amino acid sequence identified in SEQ ID NO: 1 is substituted with a cysteine (Cys) residue. In addition, the invention provides a mutant of a G-CSF in which a cysteine (Cys) residue is inserted between a glycine (Gly) residue at position 135 and an alanine (Ala) residue at position 136 of G-CSF. Further, the invention provides a chemically conjugated mutant G-CSF to which biocompatible polymer such as polyethylene glycol (PEG) was attached at the cysteine residue, which was introduced by the substitution or insertion mutation, increasing its in vivo retention time without reducing in vivo biological activity due to the conjugation with the biocompatible polymer, thereby ultimately extending the in vivo biological activity. | 2008-08-21 |
20080200658 | Process For The Purification Of Il-18 Binding Protein - The invention relates to a process for the production of purified IL-18 binding protein (IL-18BP) from a fluid comprising affinity chromatography. | 2008-08-21 |
20080200659 | Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold - Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method. | 2008-08-21 |
20080200660 | Method for the hydrophobisation of DNA molecules - The present invention relates to a method for the hydrophobisation of DNA molecules comprising mixing an aqueous solution of the DNA molecule with a solution of a cationic lipid or a surfactant in an organic solvent under agitation for a period in the range of 30 to 60 minutes to obtain the hydrophobic DNA in organic phase. | 2008-08-21 |
20080200661 | COMPOSITION FOR IN VIVO DELIVERY - The present invention relates to the delivery of desired compounds (e.g., nucleic acids) into cells using releasable delivery systems which include complexing nucleic acids and delivery ligands. | 2008-08-21 |
20080200662 | 9-Fatty Acid Hydroperoxide Lyase Genes - A 9-fatty acid hydroperoxide lyase gene consisting of the nucleotide sequence as set forth in SEQ ID No: 1, and a 9-fatty acid hydroperoxide lyase gene consisting of the nucleotide sequence as set forth in SEQ ID No: 5. | 2008-08-21 |
20080200663 | NOVEL LENTIVIRAL VECTORS FOR SITE-SPECIFIC GENE INSERTION - Murine leukemia virus (MLV) and lentivirus vectors have been used previously to deliver genes to hematopoietic stem cells (HSCs) in human gene therapy trials. However, these vectors integrate randomly into the host genome, leading to disruption or inactivation of vital host genes. The present invention discloses a novel lentiviral vector system that overcomes this problem by integrating into a host genome in a site-specific manner. | 2008-08-21 |
20080200664 | CELL REGULATORY GENES, ENCODED PRODUCTS, AND USES RELATED THERETO - This application describes the cloning of p63, a gene at chromosome 3q27-29, that bears homology to the tumor suppressor p53. The p63 gene encodes at least six different isotypes. p63 was detected in a variety of human and mouse tissue and demonstrates remarkably divergent activities, such as the ability to transactivate p53 reporter genes and induce apoptosis. Isotypes of p63 lacking a transactivation domain act as dominant negatives towards the transactivation by p53 and p63. | 2008-08-21 |
20080200665 | Nucleic acid molecules encoding proteins which impart the adhesion of Neisseria cells to human cells - Described are nucleic acid molecules encoding proteins mediating the adhesion of bacteria of the genus | 2008-08-21 |
20080200666 | Production Of Glucosamine From Plant Species - The present invention relates to a process for generating glucosamine from plants wherein fresh plant materials, or re-hydrated dried plant materials or plant extracts, are heated at a temperature comprised between 70 and 110° C. for more than 10 hours, characterized in that a glucosamine precursor is added to said plant materials, rehydrated plant materials or plant extracts. | 2008-08-21 |
20080200667 | METHOD FOR PRODUCING CELLULOSE ACYLATE FILM - Cellulose with a calcium (Ca) content of at most 10 ppm is used as a raw material of cellulose acylate. The cellulose acylate is synthesized by esterification of cellulose with carboxylic acid such as acetic acid. A dope containing the cellulose acylate and a solvent is continuously cast onto a belt, which is a support, to form a casting film. The casting film is peeled off from the belt as a film, and then the film is dried. | 2008-08-21 |
20080200668 | Industrial Process for the Preparation of 17-Hydroxy-6Beta, 7Beta; 15Beta, 16Beta-Bismethylene-3-Oxo-17Alpha-Pregn-4-Ene-21-Carboxylic Acid Y-Lactone and Key Intermediates for this Process - The invention relates to an industrial process for the preparation of 17-hydroxy-6β,7β;15β,16β-bismethylene-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone of formula (I), and to the key-intermediates for this process. | 2008-08-21 |
20080200669 | Processes For Production of Phenolic 4-Biphenylylazetidin-2-Ones - The present invention relates to processes for the production of phenolic 4-biphenylylazetidin-2-one derivatives of formula | 2008-08-21 |
20080200670 | METHOD FOR THE MANUFACTURE OF CEFTRIAXONE SODIUM - An improved process for preparation of ceftriaxone sodium of formula (II), | 2008-08-21 |
20080200671 | Crystal form of asenapine maleate - The invention relates to an orthorhombic crystal form of compound trans-5-chloro-2,3,3a, 12b-tetrahydro-2-methyl-1H-dibenz [2,3:6,7] oxepino [4,5-c] pyrrole (Z)-2-butenedioate, to methods for the preparation of this crystal form and to pharmaceutical compositions comprising an orthorhombic crystal form. | 2008-08-21 |
20080200672 | Highly enantioselective carbonyl reduction with borane catalyzed by chiral spiroborate esters derived from chiral beta-aminoalcohols - Novel spiroborate esters derived from non-recemic 1,2-amino alcohols were examined as chiral catalyst in the borane reduction of acetophenone and other aromatic ketones at room temperature. The optically active alcohols were obtained in excellent chemical yields and up to 99% ee with less than 10% catalyst. | 2008-08-21 |
20080200673 | Process for The Preparation of Sulfonic Acid Salts of Oxabispidines - There is provided a process for the isolation of a sulfonic acid salt of formula I, or a solvate thereof, from a mixture comprising: (i) the corresponding free base; and (ii) a compound of formula III. or a salt and/or solvate thereof, which process comprises providing an aqueous dispersion of the compounds of formulae II and III and a source of R | 2008-08-21 |
20080200674 | SUBSTITUTED OXAZOLIDINONES AND THEIR USE IN THE FIELD OF BLOOD COAGULATION - The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) | 2008-08-21 |
20080200675 | Method for Production of Substituted Phenylmalonate Esters, Novel Phenylmalonate Esters and Use Thereof - A process for preparing substituted phenylmalonic esters of the formula | 2008-08-21 |
20080200676 | Process for the synthesis of CMHTP and intermediates thereof - The present invention provides 3-benzyloxy-2-aminopyridine (BOPA), 3-(2-Hydroxyethyl)-2-methyl-9-hydoxy-4H-pyrido[1,2-a]pyrimidine-4-one (HMBP), 3-(2-Chloroethyl)-2-methyl-9-hydoxy-4H-pyrido[1,2-a]pyrimidine-4-one (CMHP) and 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrrido[1,2-a]- pyrimidin-4-one (CMHTP) useful as intermediates for the preparation of paliperidone. The present invention also provides processes for preparing these intermediates and for preparing paliperidone. | 2008-08-21 |
20080200677 | Metal Complexes - The present invention describes novel ionic metal complexes. Compounds of this type can be employed as functional materials in a number of different applications which can be ascribed to the electronics industry in the broadest sense. | 2008-08-21 |
20080200678 | Metallic Compound and Organic Electroluminescence Device Comprising the Same - The present invention relates to a light-emitting transition metal compound represented by the Chemical Formula 1 and Chemical Formula 2 and an organic electroluminescence device including the same. | 2008-08-21 |
20080200679 | Alpha-HYDROXY, alpha-SUBSTITUTED METHYLENEBISPHOSPHONATES AND PHOSPHONOACETATES - The present invention relates to a method for preparing α-hydroxy, α-substituted methylenebisphosphonates and phosphonoacetates via addition of Grignard or organoindium reagents to tetraalkyl carbonylbisphosphonates and trialkyl carbonylphosphonoacetates. Also disclosed are compounds so synthesized. | 2008-08-21 |
20080200680 | Polymorph Transformation of Zolpidem in Tablet Matrix - A method for converting polymorphs of Zolpidem hemitartrate, the method comprising treating tablets comprising Zolpidem hemitartrate with heat and/or moisture. | 2008-08-21 |
20080200681 | Processes for preparing palonosetron salts - The present invention provides processes for preparing Palonosetron salts, especially, the hydrochloride salt and intermediates used to prepare Palonosetron salts. | 2008-08-21 |
20080200682 | Process of Producing Bleach Boosters - This invention relates to a process of producing compounds, which are useful as bleach boosters, as well as to the compounds, which are obtainable using said process, and to their use. | 2008-08-21 |
20080200683 | Process for Preparing (Alpha S, Beta R)-6-Bromo-Alpha-[2-(Dimethylamino) Ethyl]-2-Methoxy-Alpha-1-Naphthalenyl-Beta-Phenyl-3-Quinolineethanol - The present invention relates to a process for isolating (αS,βR)-6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol from a mixture of stereoisomeric forms of 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol by optical resolution with chiral 4-hydroxydinaphtho[2,1- | 2008-08-21 |
20080200684 | Process for Preparing Ethyl (s)-2-Ethoxy-4-[N-[1-(2-Piperidinophenyl)-3-Methyl-1-Butyl]Aminocarbonyl Methyl]Benzoate and Use Thereof for the Preparation of Repaglinide - Described herein is an improved, commercially viable and industrially advantageous process for the preparation of Repaglinide intermediate, ethyl (S)-2-ethoxy-4-[N-(1-(2-piperidino-phenyl)-3-methyl-1-butyl)-aminocarbonylmethyl]-benzoate. The process provides the Repaglinide intermediate in higher yield and purity compared to the previously disclosed processes, thereby providing for production of Repaglinide and its pharmaceutically acceptable salts in high purity and in high yield. | 2008-08-21 |
20080200685 | Method for Preforming Oxidation Catalysts - Processes comprising providing a catalyst precursor, and heating the catalyst precursor to a temperature of at least 350° C. in an atmosphere comprising air, wherein air is fed into the atmosphere at a rate of 0.05 to 4.0 standard m | 2008-08-21 |
20080200686 | Method for the Isomerisation of Transition Metal Complexes Containing Cyclometallated, Carbene Ligands - The present invention relates to a process for converting an isomerically pure compound C | 2008-08-21 |
20080200687 | Preparation of Terazole Derivatives - The invention relates to a process for the preparation of (S)-pyrrolidine-1H-tetrazole derivatives of formula | 2008-08-21 |
20080200688 | Explosive complexes - Lead-free primary explosives of the formula [M | 2008-08-21 |
20080200689 | 1-Substituted-4-nitroimidazole compound and method for preparing the same - The present invention relates to a 1-substituted-4-nitroimidazole compound represented by the general formula (1) or a salt thereof, | 2008-08-21 |
20080200690 | Preparation of 2-Substituted 4-Chloro-5-Formylimidazole and 5-Formylimidazole - The invention relates to a preparation process for 2-substituted 5-formylimidazoles, wherein the intermediate high-pressurized synthesis of an 2-substituted 4-hydroxymethylimidazole as known in the art is conveniently avoided, and wherein much higher yields are obtained. Instead, it is proposed to prepare such 2-substituted 5-formylimidazoles via a one-pot synthesis involving 2-substituted 4-chloro-5-formylimidazole, thereby employing an additional hydrodehalogenation step. Moreover, it is found that the yield and purity of 2-substituted 4-chloro-5-formylimidazole itself can be significantly improved using a triflate catalyst in the preparation process. | 2008-08-21 |
20080200691 | Process For the Synthesis of Organic Compounds - The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is an intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II): | 2008-08-21 |
20080200692 | Process For the Synthesis of Organic Compounds - The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is a key intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II): | 2008-08-21 |
20080200694 | Process for Making Phenoxy Benzamide Compounds - A process for making a compound of formula (I), said process comprising a) reacting a compound of formula (II) with: i) a compound of formula (III) by nucleophilic aromatic substitution of X | 2008-08-21 |
20080200695 | Unsymmetrically Substituted Phospholane Catalysts - The present invention is based on new ligand systems of the general formula (I). These ligand systems can be used advantageously in transition metal-catalysed asymmetric syntheses. Likewise encompassed are the transition metal complexes thus prepared, a process for preparing the ligands and the use of the complexes in asymmetric synthesis. | 2008-08-21 |
20080200696 | SEPARATION PROCESS USING AROMATIC-SELECTIVE POLYMERIC MEMBRANES - Processes are disclosed for production of value-added products from fluid admixtures of hydrocarbon compounds at least one of which is an aromatic hydrocarbon compound, by means of one or more devices using perm-selective polymeric membranes. More particularly, processes of the invention comprise separations using aromatic-selective polymeric materials comprising long-chain polymeric molecules in which recurring amide and imide linkages are part of the main polymer chain. Processes of the invention advantageously employ aromatic-selective membranes to separate an aromatic enriched stream from gaseous and/or liquid mixtures comprising one or more aromatic hydrocarbon compounds thereby producing a stream comprising the remaining compounds which may include alkenes and/or alkanes containing 3 or more carbon atoms, and/or alicyclic hydrocarbons. Processes of the invention are particularly useful for recovery of meta-xylene and para-xylene products from liquid mixtures even containing ethylbenzene as well as the three xylene isomers. | 2008-08-21 |
20080200697 | Process for the preparation of 1-aryl-3,4-dihydro-1H-naphthalene-2-one - 1-aryl-3,4-dihydro-1H-naphthalene-2-one is prepared by isomerizing an epoxy compound represented by the following general formula, | 2008-08-21 |
20080200698 | PROCESS FOR PREPARING 5-HYDROXYMETHYLFURFURAL VIA 5-ACYLOXYMETHYLFURFURAL AS AN INTERMEDIATE - 5-hydroxymethylfurfural of the formula II | 2008-08-21 |
20080200699 | Method for Preparing Docetaxel - The invention concerns a method for preparing docetaxel from paclitaxel, including the following steps: a) deacylating paclitaxel, b) protecting the free hydroxy functions, in 7-, 10- and 2′-position respectively, c) debenzoylating the amine in 3′-position, into a primary amine derived for 10-deacetylbaccatine whereof the hydroxy functions in 7-, 10- and 2′-position are protected, d) functionalizing the amine with a t-butoxycarbonyl In radical to obtain a docetaxel derivative of general formula (I), wherein: X represents protecting radicals or hydrogen atoms, then, if required, e) releasing the initially protected hydroxy functions to obtain docetaxel. | 2008-08-21 |
20080200700 | SEMISYNTHESIS PROCESS FOR THE PREPARATION OF 10 DEACETYL-N-DEBENZOYL-PACLITAXEL - The invention relates to a process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel (I) | 2008-08-21 |
20080200701 | Method For Making a Chlorohydrin Starting With a Polyhydroxylated Aliphatic Hydrocarbon - Process for preparing a chlorohydrin by reacting a polyhydroxylated aliphatic hydrocarbon with a chlorinating agent in a reactor which is supplied with one or more liquid streams containing less than 50% by weight of the polyhydroxylated aliphatic hydrocarbon relative to the weight of the entirety of the liquid streams. | 2008-08-21 |
20080200702 | Novel Intermediates, Process for Their Preparation and Process for the Preparation of Coq10 Employing the Said Novel Intermediates - The present invention relates to an improved process for the preparation of Coenzyme Q. Coenzyme Q | 2008-08-21 |
20080200703 | Heterogeneous Ruthenium Catalyst and Method For Hydrogenating a Carboxylic Aromatic Group, in Particular For Producing Core Hydrogenated Bisglycidyl Ether Bisphenols A and F - Heterogeneous ruthenium catalyst which comprises amorphous silicon dioxide as support material and can be produced by single or multiple impregnation of the support material with a solution of a ruthenium salt, drying and reduction, wherein the silicon dioxide support material used has a BET surface area (in accordance with DIN 66131) in the range from 250 to 400 m | 2008-08-21 |
20080200704 | PREPARATION OF AMINO ACID-FATTY ACID AMIDES - The present invention describes compounds produced from an amino acid molecule and a fatty acid molecule. The compounds being in the form of amino-fatty acid compounds being bound by an amide linkage, or mixtures thereof made by reacting amino acids or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental amino acids with enhanced bioavailability and the additional benefits conferred by the specific fatty acid. | 2008-08-21 |
20080200705 | CREATINE-FATTY ACIDS - The present invention describes compounds produced from a creatine molecule and a fatty acid molecule. The compounds being in the form of creatine-fatty compounds bound by an amide linkage, or mixtures thereof produced by reacting creatine or derivatives thereof with an appropriate fatty acid in the presence of dichloromethane and a pyridine catalyst, previously reacted with a thionyl halide. The administration of such molecules provides supplemental creatine with enhanced bioavailability and the additional benefits conferred by the specific fatty acid. | 2008-08-21 |
20080200706 | Conjugated Linoleic Acid Compositions - Novel compositions containing conjugated linoleic acids are efficacious as animal feed additives and human dietary supplements. Linoleic acid is converted to its conjugated forms in which the resulting composition is low in certain unusual isomers compared to conventional conjugated linoleic products. In addition, the inventions provides compositions that are prepared according to a novel method that controls oxidation of CLA into volatile organic compounds as well as containing metal oxidant chelators to control oxidation during storage. | 2008-08-21 |
20080200707 | Lipotoxicity Relieving Agent - In view of the situation that a clinically acceptable medical agent which has the action of preventing and relieving the lipotoxicity with no significant side effects is not yet provided, such medical agent is provided. An agent for relieving lipotoxicity which comprises an unsaturated fatty acid containing 18 to 22 carbon atoms and having a degree of unsaturation of 3 to 6 or a derivative thereof as its effective component. | 2008-08-21 |
20080200708 | Preparation of Partially Hydrogenated Rac-Ansa-Metallocene Complexes - The invention relates to a process for preparing hydrogenated or partially hydrogenated, racemic ansa-metallocene complexes by reacting bridged or unbridged transition metal complexes with alkali metal compounds or alkaline earth metal compounds, heating the resulting reaction mixture to a temperature in the range from −78 to 250° C. and at least partially hydrogenating the reaction products in the presence of a suitable catalyst, to the corresponding hydrogenated or partially hydrogenated metallocenes and to their use as catalysts or as a constituent of catalysts for the polymerization of olefinically unsaturated compounds or as reagents or catalysts in stereoselective synthesis. | 2008-08-21 |
20080200709 | Chain growth reaction process - A process is disclosed for the preparation of zinc alkyl chain growth products via a catalysed chain growth reaction of an alpha-olefin on a zinc alkyl, wherein the chain growth catalyst system employs a group 3-10 transition metal, or a group 3 main group metal, or a lanthanide or actinide complex, and optionally a suitable activator. The products can be further converted into alpha-olefins by olefin displacement of the grown alkyls as alpha-olefins from the zinc alkyl chain growth product, or into primary alcohols, by oxidation of the resulting zinc alkyl chain growth product to form alkoxide compounds, followed by hydrolysis of the alkoxides. | 2008-08-21 |
20080200710 | PREPARATION OF DIMETHYLCHLOROSILANE - Dimethylchlorosilane is prepared by reacting 1,2-tetramethyldichlorodisilane with hydrogen chloride in the presence of a catalyst mixture of a) palladium, b) a tertiary amine, and c) a tertiary phosphine having at least one phenyl group having at least one functional group other than hydrogen. The catalyst does not lose its activity upon contact with hydrogen chloride at low temperatures and ensures production of dimethylchlorosilane in high yields. | 2008-08-21 |
20080200711 | PROCESS FOR THE PREPARATION OF AN ALKANEDIOL AND A DIALKYL CARBONATE - An alkanediol and a dialkyl carbonate are prepared in a process comprising: | 2008-08-21 |
20080200712 | PROCESS FOR THE PREPARATION OF DIARYL CARBONATE - The invention relates to a process for the preparation of a diaryl carbonate by transesterification of an aromatic alcohol with a dialkyl carbonate in the presence of a transesterification catalyst during a period of time [t | 2008-08-21 |
20080200713 | Process for Manufacturing Dimethyl Carbonate - The present invention provides methods of forming dialkyl carbonate wherein catalyst buildup in the reaction equipment, the separation equipment, and transfer lines there between is reduced and even eliminated. In one embodiment, the method includes introducing alkanol, carbon monoxide, oxygen, and a catalyst to a reactor having a gaseous head space and a liquid body space. The reactor is operated under conditions to form dialkyl carbonate and water. A product stream containing dialkyl carbonate, water, and residual reactants is removed from the head space of the reactor and introduced to a cyclone with a flushing stream. A liquid bottom stream is captured from the cyclone and introduced to the reactor. The gaseous top stream contains product dialkyl carbonate. | 2008-08-21 |
20080200714 | Process for Manufacturing Dimethyl Carbonate - A method of forming a dialkyl carbonate stream, includes obtaining a byproduct stream from a diaryl carbonate formation reaction that has alkanol, residual dialkyl carbonate, and residual aromatic compound. This byproduct stream is introduced to a distillation column to produce an alkanol tops stream and a first dialkyl carbonate bottoms stream. The alkanol tops stream is reacted with oxygen, carbon monoxide, and catalyst to form a second dialkyl carbonate stream that is introduced to the distillation column. The alkanol tops stream from the column contains alkanol, dialkyl carbonate, and less than 20 ppm aromatic compound. The first dialkyl carbonate bottoms stream from the column contains dialkyl carbonate, water, aromatic compound, and less than 2,000 ppm alkanol and is introduced to a water separation device to produce a product dialkyl carbonate stream and a water stream. | 2008-08-21 |
20080200715 | PROCESS FOR THE AMMOXIDATION OF PROPANE AND ISOBUTANE - A process for the ammoxidation of a saturated or unsaturated or mixture of saturated and unsaturated hydrocarbon to produce an unsaturated nitrile, said process comprising contacting the saturated or unsaturated or mixture of saturated and unsaturated hydrocarbon with ammonia and an oxygen-containing gas in the presence of a catalyst composition comprising molybdenum, vanadium, antimony, niobium, tellurium, optionally at least one element select from the group consisting of titanium, tin, germanium, zirconium, hafnium, and optionally at least one lanthanide selected from the group consisting of lanthanum, cerium, praseodymium, neodymium, samarium, europium, gadolinium, dysprosium, holmium, erbium, thulium, ytterbium and lutetium. Such catalyst compositions are effective for the gas-phase conversion of propane to acrylonitrile and isobutane to methacrylonitrile (via ammoxidation). | 2008-08-21 |
20080200716 | Mixed metal oxide catalysts for the ammoxidation of propane and isobutane - A process for the ammoxidation of a saturated or unsaturated or mixture of saturated and unsaturated hydrocarbon to produce an unsaturated nitrile, said process comprising contacting the saturated or unsaturated or mixture of saturated and unsaturated hydrocarbon with ammonia and an oxygen-containing gas in the presence of a catalyst composition comprising molybdenum, vanadium, antimony, niobium, tellurium, optionally at least one element select from the group consisting of titanium, tin, germanium, zirconium, hafnium, and optionally at least one lanthanide selected from the group consisting of lanthanum, cerium, praseodymium, neodymium, samarium, europium, gadolinium, dysprosium, holmium, erbium, thulium, ytterbium and lutetium. Such catalysts are characterized by very low levels of tellurium in the composition. Such catalyst compositions are effective for the gas-phase conversion of propane to acrylonitrile and isobutane to methacrylonitrile (via ammoxidation). | 2008-08-21 |
20080200717 | Process For Producing Ethers - The invention is directed to a process for producing the compound 4-(4-Hydroxy-1-methyl-pentyloxy)-2-trifluo-romethyl-benzonitrile or a pharmaceutically acceptable salt thereof. | 2008-08-21 |
20080200718 | Novel material forming supramolecular structures, process and uses - The invention relates to novel material, forming supramolecular structures below its transition temperature, which contains at least one C=O and/or C=S group and at least one N—H, O—H and/or S—H group and wherein the material has the structure | 2008-08-21 |
20080200719 | Acid and base stable diphenylmethanol derivatives and methods of use - The invention provides compounds that are useful as linkers for solid phase synthesis and as protecting groups, and methods for producing and using the same. | 2008-08-21 |
20080200720 | PROCESS FOR THE SYNTHESIS OF ENANTIOMERIC INDANYLAMINE DERIVATIVES - A process for manufacturing (R)-propynylaminoindans, and alternatively, a process for manufacturing (S)-propynylaminoindans. The chiral propynylaminoindans include alkoxy or alkylcarbamates derivatives. The process comprises transfer or pressure hydrogenation in the presence of an optically active catalyst to reduce 1-indanones. The chiral product, either (S)- or (R)-indanols undergo nucleophilic substitution to produce the named product. In an additional aspect, the invention relates to novel intermediates and compounds, namely, substituted indanones, substituted (S)-indanols and substituted (R)-indanols. | 2008-08-21 |
20080200721 | Mdi Production By Means of Liquid Phase and Gas Phase Phosgenation - The invention relates to a process for preparing isocyanates, which comprises the
| 2008-08-21 |
20080200722 | Method For Producing Diisocyanates - The present invention relates to a process for preparing diisocyanates from diamines and phosgene in the gas phase. | 2008-08-21 |
20080200723 | CREATINE-FATTY ACIDS - The present invention describes compounds produced from a creatine molecule and a fatty acid molecule. The compounds being in the form of creatine-fatty acid compounds being bound by an anhydride linkage, or mixtures thereof made by reacting creatine or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental creatine with enhanced bioavailability and the additional benefits conferred by the specific fatty acid. | 2008-08-21 |
20080200724 | Process and Compound - The present invention relates to a process for preparing certain sulphonamide intermediates useful in the preparation of HIV inhibitors and to the crystal forms thereof. | 2008-08-21 |
20080200725 | PREPARATION OF AMINO ACID-FATTY ACID ANHYDRIDES - The present invention describes compounds produced from an amino acid molecule and a fatty acid molecule. The compounds being in the form of amino-fatty acid compounds being bound by an anhydride linkage, or mixtures thereof made by reacting amino acids or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental amino acids with enhanced bioavailability and the additional benefits conferred by the specific fatty acid. | 2008-08-21 |
20080200726 | Method For the Continuous Production of an Amine - Processes comprising: providing an aromatic alcohol; and reacting the aromatic alcohol with ammonia at a temperature of 80 to 350° C. in the presence of hydrogen and a heterogeneous catalyst to form a crude reaction product comprising a corresponding primary aromatic amine, wherein the heterogeneous catalyst comprises a catalytically active composition which, prior to reduction with hydrogen, comprises 90 to 99.8% by weight of zirconium dioxide (ZrO | 2008-08-21 |
20080200727 | Method for Producing an Amine - Processes for preparing amines comprising reacting an aldehyde and/or ketone with hydrogen and a nitrogen compound in the presence of a heterogeneous catalyst, wherein the heterogeneous catalyst comprises a catalyst packing prepared by applying at least one compound selected from the group consisting of catalytically active metals, compounds of catalytically active metals, and mixtures thereof to a support material selected from the group consisting of woven fabrics, knitted fabrics, foils, and combinations thereof. | 2008-08-21 |
20080200728 | Process for Synthesis of Dialkoxyorganoboranes - The invention relates to a process for the synthesis of dialkoxyorganoboranes, in particular to a process for the synthesis of dialkoxyorganoboranes by an ester exchange reaction. Moreover, the invention relates to a process for the synthesis of organo-oxazaborolidine catalysts (organo-CBS) and of trialkylboroxins. Furthermore, the invention relates to methods of using dialkoxyorganoboranes for the preparation of organo-CBS catalysts and in Suzuki-type coupling reactions. | 2008-08-21 |
20080200729 | Preparation of Aryl Phosphines - A method of making an aryl phosphine is provided. The method comprises reacting an organophosphine of general formula (1): HPXY with a substituted aryl compound in the presence of a catalyst, a base, a ligand and an iodine containing co-catalyst. In formula (1) X and Y can be the same or different and are cycloalkyl; substituted alkyl; primary, secondary and tertiary alkyl; and heterocyclic moieties; and one of X and Y can optionally be hydrogen. | 2008-08-21 |
20080200730 | PROCESS FOR PREPARING METHYL MERCAPTAN FROM DIALKYL SULPHIDES AND DIALKYL POLYSULPHIDES - A process for continuously preparing methyl mercaptan by reacting a reactant mixture which contains a dialkyl sulphide and a dialkyl polysulphide with hydrogen sulphide to give methyl mercaptan. | 2008-08-21 |
20080200731 | Polyhalogen-substituted cinnamic acids and cinnamic acid derivatives and a process for the preparation of polyhalogen-substituted cinnamic acids and cinnamic acid derivatives - Polyhalogenated cinnamic acids and cinnamic acid derivatives are prepared by reacting diazonium salts accessible from polyhalogenated anilines with acrylic acid or acrylic acid derivatives in the presence of a homogeneous, palladium-containing catalyst at about −5 to about +100° C. Some of the cinnamic acids and cinnamic acid derivatives obtainable in this way are new. Cinnamic acids and cinnamic acid derivatives which can be prepared according to the invention can be used for the preparation of indanones which are precursors for agro- and pharmaceutical chemicals and for substances having liquid-crystalline properties. | 2008-08-21 |
20080200732 | Novel Intermediates Useful for the Preparation of Coenzymes, Process for the Preparation of Novel Intermediates and an Improved Process for the Preparation of Coenzymes - The present invention relates to novel intermediates for the preparation of coenzymes, processes for the preparation of the intermediates and an improved process for the preparation of Coenzymes. The present invention particularly relates to an improved process for the preparation of Coenzyme Q, more particularly for Conenzyme Q | 2008-08-21 |
20080200733 | Processes For The Preparation Of Purified Solanesol, Solanesyl Bromide & Solanesyl Acetone - The present invention relates to processes for the preparation of purified solanesol, solanesyl bromide & solanesyl acetone. Solanesyl acetone has the chemical name—all—trans 6,10,14,18,22,26,30,34,38-nonamethyl-5,9,13,17,21,25,29,33,37-triacontanonaen-2-one, of formula 1 and is used for synthesis of coenzyme Q | 2008-08-21 |
20080200734 | CRYSTALLIZATION PROCESSES FOR PRODUCING BISPHENOLS - Processes for producing bisphenols (e.g., bisphenol A (BPA)) having a purity greater than 99.7% are described, such processes including reacting a phenol and acetone in the presence of an acidic catalyst to form a product mixture comprising a bisphenol; removing at least a portion of the bisphenol from the product mixture in the form of a bisphenol/phenol adduct by crystallization, filtration and washing to provide bisphenol/phenol adduct crystals; and removing at least a portion of the phenol from the bisphenol/phenol adduct crystals to provide the bisphenol having a purity of more than 99.7%; wherein the crystallization comprises continuous suspension crystallization and is carried out in at least three crystallization devices arranged such that the product mixture is first cooled in a first stage of the crystallization to a temperature of 50 to 70° C. in a first crystallization device and a second crystallization device connected in parallel, and subsequently cooled in a second stage of the crystallization to a temperature of 40 to 50° C. in a third crystallization device connected downstream in series to the first and second crystallization devices, and wherein a total dwell time of the product mixture in the crystallization is more than 4 hours. | 2008-08-21 |
20080200735 | Catalyst for the synthesis of CF3I and CF3CF2I - A process for the preparation of a fluoroiodoalkane compound represented by the formula: CF | 2008-08-21 |
20080200736 | MATERIAL FOR ORGANIC LIGHT-EMITTING ELEMENT AND ORGANIC LIGHT-EMITTING ELEMENT INCLUDING THE SAME - A fluorene compound and an organic light-emitting element including the fluorene compound are provided. The fluorene compound is represented by the following general formula [1], and the fluorene compound is a material for an organic light-emitting element. A steric hindrance group is introduced directly on a fluorene ring in the fluorene compound. | 2008-08-21 |
20080200737 | Process for Breaking the Carbon Chains of Organic Molecules of Solid Materials and Related Apparatus - A process for breaking chains of organic molecules in which solid material comprising organic molecules is subjected to a mechanical stretching and squashing action, until it assumes a pasty consistency that by internal friction is subjected to a temperature and pressure increase in the absence of air, which breaks its long molecular bonds and determines the separation of the phases of the components. | 2008-08-21 |
20080200738 | PYROLYTIC PROCESS AND APPARATUS FOR PRODUCING ENHANCED AMOUNTS OF AROMATC COMPOUNDS - A pyrolysis process and reactor converts various hydrocarbons such as waste materials, for example, scrap polymers, tires, etc., into various chemical components or amounts thereof, not otherwise produced by conventional pyrolytic processes. A large reactor size is utilized in association with a low heat input per unit weight of charge. A thick pyrolyzate/“char” layer is formed during pyrolysis. The product or various components thereof can be utilized as a fuel or octane additive. | 2008-08-21 |
20080200739 | Catalyst For the Dehydrogenation or Hydrogenation of Hydrocarbons Containing Secondary Catalyst - Catalysts comprising: a ground, spent (de)hydrogenation catalyst material present in an amount of 10 to 70% by weight based on the catalyst, the ground, spent catalyst material comprising iron oxide; and a fresh catalyst material present in an amount of 30 to 90% by weight based on the catalyst, the fresh catalyst material comprising iron oxide, wherein at least a portion of the iron oxide in the fresh catalyst material comprises a phase selected from the group consisting of hematite, potassium ferrite, and mixtures thereof are described along with processes for preparing and using the same. | 2008-08-21 |
20080200740 | PROCESS FOR CONVERTING GASEOUS ALKANES TO OLEFINS AND LIQUID HYDROCARBONS - A process for converting gaseous alkanes to olefins and higher molecular weight hydrocarbons wherein a gaseous feed containing alkanes is reacted with a dry bromine vapor to form alkyl bromides and hydrobromic acid vapor. The mixture of alkyl bromides and hydrobromic acid are then reacted over a synthetic crystalline alumino-silicate catalyst, such as an X or Y type zeolite, at a temperature of from about 250° C. to about 500° C. so as to form olefins, higher molecular weight hydrocarbons and hydrobromic acid vapor. Various methods are disclosed to remove the hydrobromic acid vapor from the higher molecular weight hydrocarbons and to generate bromine from the hydrobromic acid for use in the process. | 2008-08-21 |
20080200741 | DEHYDROGENATION CATALYST, PROCESS FOR PREPARATION, AND A METHOD OF USE THEREOF - A process for preparing a dehydrogenation catalyst comprising preparing a mixture comprising a treated regenerator iron oxide and at least one additional catalyst component; and calcining the mixture wherein the treated regenerator iron oxide is prepared by washing a regenerator iron oxide at a temperature below 350° C. such that the treated regenerator iron oxide has a chloride content of at most 500 ppmw relative to the weight of iron oxide, calculated as Fe | 2008-08-21 |
20080200742 | Para-Xylene Selective Adsorbent Compositions and Methods - Adsorbent compositions for vapor-phase adsorption processes, which are selective for para-xylene. Such compositions can be used in gas-phase adsorption processes for the separation of para-xylene or the separation of para-xylene and ethylbenzene from mixed xylenes or a C | 2008-08-21 |
20080200743 | Methods For Oligomerizing Olefins With Chromium Pyridine Ether Catalysts - The present invention provides a method of producing oligomers of olefins, comprising reacting olefins with a catalyst under oligomerization conditions. The catalyst can be the product of the combination of a chromium compound and a pyridyl ether compound. In particular embodiments, the catalyst compound can be used to trimerize or tetramerize ethylene to 1-hexene, 1-octene, or mixtures of 1-hexene and 1-octene. | 2008-08-21 |
20080200744 | TRIMERISATION AND OLIGOMERISATION OF OLEFINS USING A CHROMIUM BASED CATALYST - The invention provides a mixed heteroatomic ligand for an oligomerisation of olefins catalyst, which ligand includes at least three heteroatoms, of which at least one heteroatom is sulfur and at least two heteroatoms are not the same. The invention also provides a multidentate mixed heteroatomic ligand for an oligomerisation of olefins catalyst, which ligand includes at least three heteroatoms of which at least one is a sulfur atom. The ligand may also contain, in addition to sulfur, at least one nitrogen or phosphorous heteroatom. | 2008-08-21 |
20080200745 | Method For Producing Propene From 2-Butene And Isobutene-Rich Feeding Flows - Process for preparing
| 2008-08-21 |