34th week of 2014 patent applcation highlights part 58 |
Patent application number | Title | Published |
20140235822 | METHOD FOR PRODUCING PEPTIDE - The present invention provides a method for producing a peptide, characterized in that it comprises converting an —SH group of a peptide comprising an amino acid residue having the —SH group to an —OH group, wherein said method comprises the following steps (a) to (c): (a) allowing an —SH group in a peptide to react with a methylating agent to convert the —SH group to an -SMe group; (b) allowing the -SMe group obtained in the step (a) to react with a cyanizing agent to produce a reaction intermediate; and (c) converting the reaction intermediate obtained in the step (b) to a peptide comprising an amino acid residue having an —OH group under more basic conditions than the conditions in the step (b). | 2014-08-21 |
20140235823 | FUSION PROTEIN CONTAINING A SINGLE-STRANDED DNA BINDING PROTEIN AND METHODS FOR EXPRESSION AND PURIFICATION OF THE SAME - The present invention provides an expression vector comprising a promoter and a polynucleotide sequence encoding a fusion protein. The present invention further provides a method for purification of an interest protein. The present invention also provides a fusion protein comprising a single-stranded DNA binding protein and an interest protein or polypeptide fused directly or indirectly with the COOH-terminus or NH | 2014-08-21 |
20140235824 | Method to Wash Greasy Wool, A Method to Separate Lanolin from the Said Greasy Wool, Wool and Lanolin Obtainable by These Methods - A method to wash wool containing lanolin and impurities includes the steps of providing a volume of an aqueous liquid at a temperature below a melting temperature of the lanolin, soaking the wool in the volume of the liquid, creating air bubbles in the liquid and allowing the air bubbles to pass through the wool to attach the impurities, removing the air bubbles and attached impurities from the volume, and separating lanolin from wool containing lanolin and impurities, along with the wool and lanolin obtainable by this method. | 2014-08-21 |
20140235825 | BIOCOMPATIBLE PHASE INVERTIBLE PROTEINACEOUS COMPOSITIONS AND METHODS FOR MAKING AND USING THE SAME - Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. Phase invertible compositions in accordance with the invention are prepared by combining a liquid proteinaceous substrate and a liquid crosslinking composition, where the liquid crosslinking composition includes a macromolecular crosslinking agent. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications. | 2014-08-21 |
20140235826 | OPTICALLY-BASED STIMULATION OF TARGET CELLS AND MODIFICATIONS THERETO - Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated molecule comprising a nucleic acid sequence that codes for light-activated molecule. The light-activated molecule includes a modification to a location near the all-trans retinal Schiff base, e.g., to extends the duration time of the open state. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion channels or pumps or for controlling currents in a cell (e.g., in in vivo and in vitro environments). | 2014-08-21 |
20140235827 | MOUSE ANTI-AGGRUS MONOCLONAL ANTIBODIES - The present invention provides a monoclonal antibody or a functional fragment thereof, capable of recognizing Aggrus epitope comprising an amino-acid sequence represented by a sequence ID 1, 3, or 4, and the monoclonal antibody or the functional fragment thereof produced from a hybridoma with deposit ID of FERM BP-11446, FERM BP-11447, FERM BP-11448 or FERM BP-11449. The present invention provides the hybridoma, and further an Aggrus-CLEC-2 binding inhibitor and a pharmaceutical composition for inhibition of platelet aggregation, prevention of cancer metastasis, or treatment of tumor or cancer, comprising the monoclonal antibody or the functional fragment thereof. | 2014-08-21 |
20140235828 | GRAM-POSITIVE BACTERIA SPECIFIC BINDING COMPOUNDS - The present invention provides improved binding compounds capable of specifically binding Gram-positive bacteria. Binding compounds are provided that are fully human, enabling therapeutic applications in human individuals. | 2014-08-21 |
20140235829 | Compositions And Methods For Regulation Of Tumor Necrosis Factor-Alpha - The present invention relates to compositions and methods relating to an interleukin 18-inducible cytokine termed tumor necrosis factor-alpha inducing factor (TAIF) or interleukin-32 (IL-32). In particular, the present invention provides compositions and methods for treating autoimmune diseases and cancer, in part by regulation of tumor necrosis factor-alpha expression. | 2014-08-21 |
20140235830 | ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9) - Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described. | 2014-08-21 |
20140235831 | ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9) - Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described. | 2014-08-21 |
20140235832 | RANK LIGAND POLYPEPTIDES - Described herein are kits for use in detecting RANKL polypeptides. | 2014-08-21 |
20140235833 | METHOD OF CLASSIFYING ANTIBODY, METHOD OF IDENTIFYING ANTIGEN, METHOD OF OBTAINING ANTIBODY OR ANTIBODY SET, METHOD OF CONSTRUCTING ANTIBODY PANEL AND ANTIBODY OR ANTIBODY SET AND USE OF THE SAME - The present invention relates to an isolated antibody against HER1, an isolated antibody against CD147, an isolated antibody against CD73, and an isolated antibody against EpCAM; reagents and compositions including said antibodies; and uses of said reagents, compositions, and antibodies. The present invention also relates to nucleic acids and vectors expressing said antibodies. The invention further relates to transformants comprising said nucleic acids or vectors. | 2014-08-21 |
20140235834 | METHOD FOR PREPARING POLYBIOTINYLATED COMPOUNDS - The present invention relates to compounds having the formula (I) and their use in clinical and industrial diagnosis. | 2014-08-21 |
20140235835 | CALICHEAMICIN DERIVATIVE-CARRIER CONJUGATES - Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. | 2014-08-21 |
20140235836 | Immunologic Constructs and Methods - The present invention relates to improved vaccines and the design and making of such vaccines that enhance immunogenicity of the vaccine and/or reduce reactogenicity to the vaccine when administered. In particular the vaccines and immunogenic compositions of the present invention relate to flagellin-antigen fusion proteins in which the spatial orientation of the flagellin to antigen and the charge distribution of the antigen is optimized to enhance immunogenicity and/or reduce reactogenicity and/or improve folding of the protein. | 2014-08-21 |
20140235837 | METHOD FOR PURIFYING PROTEIN - It is an object of the present invention to provide a method for eluting an adsorbed protein that suppresses a decrease in protein adsorption ability, in a method for purifying a protein using a protein-adsorbing porous membrane. | 2014-08-21 |
20140235838 | SELECTIVE AEROBIC ALCOHOL OXIDATION METHOD FOR CONVERSION OF LIGNIN INTO SIMPLE AROMATIC COMPOUNDS - Described is a method to oxidize lignin or lignin sub-units. The method includes oxidation of secondary benzylic alcohol in the lignin or lignin sub-unit to a corresponding ketone in the presence of unprotected primarily aliphatic alcohol in the lignin or lignin sub-unit. The optimal catalyst system consists of HNO | 2014-08-21 |
20140235839 | PROCESS FOR PRODUCING NOVEL SIALO-SUGAR CHAIN - The present invention provides a novel sialo-sugar chain, a process for producing the sialo-sugar chain, and a device for producing the sialo-sugar chain. A sialo-sugar chain can be easily and efficiently mass-produced by reacting a sugar wherein a hydroxy groups is substituted with an alkynyl group (herein sometimes referred to as “alkynylated sugar”) with a specific sialic acid donor in the presence of a sialic acid-introducing enzyme. | 2014-08-21 |
20140235840 | NEW SYNTHESIS OF FUCOSE - A process for converting D-glucose into L-fucose, where a first aspect of the disclosure relates to a method of making a compound of formula (1) wherein R is independently H, alkyl or phenyl or, preferably, wherein the two germinal R groups together with the carbon atom to which they are attached form a C3-s cycloalkylidene group, including the step of treating a compound of formula (2) wherein R is defined above and R | 2014-08-21 |
20140235841 | DOUBLE-STRANDED RIBONUCLEIC ACIDS WITH RUGGED PHYSICO-CHEMICAL STRUCTURE AND HIGHLY SPECIFIC BIOLOGIC ACTIVITY - The invention relates to our discovery of a novel double-stranded ribonucleic acid (dsRNA) having specific biological activities, which includes acting as a selective agonist for activation of the Toll-like receptor 3. Its “rugged” molecular structure as measured by physico-chemical techniques is resistant to molecular unfolding (i.e., denaturation). This structure appears to be responsible for increased efficacy of dsRNA in therapeutic applications and improved biological activity (e.g., used as an immunoregulatory agent). Medicaments, processes for their manufacture, and methods for their use are provided herein. | 2014-08-21 |
20140235842 | CONVENIENT AND EFFICIENT PURIFICATION METHOD FOR CHEMICALLY LABELED NUCLEIC ACIDS - The present invention relates to a method for purifying chemically labeled nucleic acids. More particularly, the present invention relates to a convenient and efficient method for purifying labeled nucleic acids in a fast manner with high efficiency from a mixture of unreacted hydrophobic probes, unreacted nucleic acids and labeled nucleic acids. | 2014-08-21 |
20140235843 | ANTIBODIES TO CD70 - The present invention relates to antibodies and antigen binding fragments thereof which bind to the human CD70 protein with high affinity and display potent inhibition of tumour cell growth. | 2014-08-21 |
20140235844 | Short Interfering RNA (siRNA) Analogues - The present invention is directed to novel double-stranded short interfering (siRNA) analogues comprising locked nucleic acid (LNA) monomers. Such compounds induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). The compounds disclosed herein has improved properties compared to non-modified siRNAs and may, accordingly, be useful as therapeutic agents, e.g., in the treatment of various cancer forms. More particularly, the present invention is directed to siRNA analogues comprising a sense strand and an antisense strand, wherein each strand comprises 12-35 nucleotides and wherein the siRNA analogues comprise at least one locked nucleic acid (LNA) monomer. | 2014-08-21 |
20140235845 | SEQUENCE AMPLIFICATION WITH LOOPABLE PRIMERS - The present disclosure relates to the amplification of target nucleic acid sequences. This can be accomplished via the use of various primers. The use of these primers, as described herein, results in nucleic acid structures that can reduce the amplification of nonspecific hybridization events (such as primer dimerization) while allowing the amplification of the target nucleic acid sequences. | 2014-08-21 |
20140235846 | Polyelectrolyte-Coated Ion-Exchange Particles - A polyelectrolyte-coated particle, devices for using the particle, methods for using the particle for separating PCR reaction products and/or DNA sequencing reaction products, and compositions for coating the particle are provided. | 2014-08-21 |
20140235847 | METHODS, COMPOSITIONS, AND KITS FOR GENERATING rRNA-DEPLETED SAMPLES OR ISOLATING rRNA FROM SAMPLES - The present invention provides methods, compositions, and kits for generating rRNA-depleted samples and for isolating rRNA from samples. In particular, the present invention provides compositions comprising affinity-tagged antisense rRNA molecules corresponding to substantially all of at least one rRNA molecule (e.g., 28S, 26S, 25S, 18S, 5.8S and 5S eukaryotic cytoplasmic rRNA molecules, 12S and 16S eukaryotic mitochondrial rRNA molecules, and 23S, 16S and 5S prokaryotic rRNA molecules) and methods for using such compositions to generate rRNA-depleted samples or to isolate rRNA molecules from samples. | 2014-08-21 |
20140235848 | METHOD FOR MAKING A PRECURSOR OF L-FUCOSE FROM D-GLUCOSE - A method that can be used to make a precursor of L-fucose from D-glucose that includes the steps of a) making a compound of formula (1) from D-glucose, formula (1) wherein R | 2014-08-21 |
20140235849 | Method for Increasing the Yield in Lactose Production (III) - Suggested is a method for improving the yield during the production of crystalline alpha lactose, wherein
| 2014-08-21 |
20140235850 | SYNTHESIS OF HMO CORE STRUCTURES - The invention relates to a method for making precursors of HMO core structures comprising a step of reacting an N-acetyllactosamine or lacto-N-biose derivative donor with a lactose or N-acetyllactosamine derivative acceptor, wherein the donor is an oxazoline donor. | 2014-08-21 |
20140235851 | Chemical Transformation of Lignocellulosic Biomass into Fuels and Chemicals - A method for converting a carbohydrate to a furan in a polar aprotic solvent in the presence of a chloride, bromide, or iodide salt or a mixture thereof and optionally in the presence of an acid catalyst, a metal halide catalyst and/or an ionic liquid (up to 40 wt %). The method can be employed in particular to produce furfural or 5-hydroxymethylfurfural. | 2014-08-21 |
20140235852 | PROCESS FOR PREPARING AN INTERMEDIATE OF THE MACROCYCLIC PROTEASE INHIBITOR TMC 435 - The present invention relates to an improved process for preparing (2R,3aR,10Z,11aS,2aR,14aR)-cyclopenta[c]cyc-lopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxylic acid, 2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2[[7-methoxy-8-methyl-2-[4-10 (1-methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-methyl-4,14-dioxo-, ethyl ester. This compound is an intermediate in the overall synthesis route of the macrocyclic compound TMC 435. TMC 435 is an inhibitor of NS3/4A protease which plays an important role in the replication of the hepatitis C virus. | 2014-08-21 |
20140235853 | Method of Preparation of epsilon-2,4,6,8,10,12-Hexanitro-2,4,6,8,10,12-Hexaazaisowurtzitane with Reduced Impact Sensitivity - The present invention relates to a method of preparation of ε-2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane with reduced impact sensitivity by precipitation of a solution of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane in a solvent by an antisolvent, wherein phosphorus(V) oxide is added as a recrystallization promoter to the solution of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane in the solvent, the obtained mixture is stirred and filtered, and the filtrate is subsequently precipitated by the addition of the antisolvent. | 2014-08-21 |
20140235854 | Process for Preparing Diaminophenothiazinium Compounds - Process for preparing compounds of the diaminophenothiazinium type of formula (II) below. The products have a high degree of purity and are useful for the preparation of medicaments. | 2014-08-21 |
20140235855 | Tricyclic Antibiotics - Compounds of formula (I), wherein A1 represents —O—, —S— or —CH | 2014-08-21 |
20140235856 | FIBROBLASTS CELLULAR MODEL FOR ASSESSING EFFICACY OF CANCER TREATMENTS BY SHH/PTCH PATHWAY ANTAGONISTS - A cellular model is described that targets dysregulation or inappropriate activation of the Sonic Hedgehog/Patched (SHH/PTCH) pathway. Also described, is a screening method using this cellular model to screen for pharmacological compounds that can treat or prevent skin cancer, in particular, Basal Cell Carcinoma, (BCC) lesions. | 2014-08-21 |
20140235857 | INTERMEDIATE FOR MANUFACTURE OF POLYMERIZABLE COMPOUND AND PROCESS FOR MANUFACTURE THEREOF - The present invention pertains to a compound represented by a formula (I) and a method for producing thereof (in the formula, A | 2014-08-21 |
20140235858 | NEUROPROTECTIVE MULTIFUNCTIONAL ANTIOXIDANTS AND THEIR MONOFUNCTIONAL ANALOGS - The neuroprotective multifunctional antioxidants are compounds that contain a 2-diacetylamino-5-hydroxypyrimidine moiety, having the structural formula: | 2014-08-21 |
20140235859 | PROCESS FOR THE RESOLUTION OF OMEPRAZOLE - The present invention relates to process for the resolution of omeprazole. The present invention further provides a novel compound of enantiomers of omeprazole cyclic amine salt and a process for preparing it. The present invention also provides a solid of (R)- or (S)-omeprazole cyclic amine salt and a process for preparing it. The present invention also provides a process for the preparation of esomeprazole magnesium dihydrate substantially free of its trihydrate form. The present invention also provides a process for the preparation of recovery of chiral BINOL. | 2014-08-21 |
20140235860 | METHOD OF PREPARING BUPRENORPHINE - An improved process for preparing buprenorphine and a method for increasing the yield of buprenorphine or a derivative thereof. | 2014-08-21 |
20140235861 | METHOD FOR THE SYNTHESIS OF 18F-LABELLED BIOMOLECULES - The present invention provides a method for the synthesis of | 2014-08-21 |
20140235862 | METHOD FOR PRODUCING 4, 4-DIFLUORO-3,4-DIHYDROISOQUINOLINE DERIVATIVES - Provided is a simple and efficient method for the large-scale production of a 4,4-difluoro-3,4-dihydroisoquinoline derivative. In the method for producing a 4,4-difluoro-3,4-dihydroisoquinoline derivative represented by general formula (1): | 2014-08-21 |
20140235863 | SUBSTITUTED 4-ARYLTHIAZOLES AND PROCESS OF PREPARATION THEREOF - The present invention relates to novel substituted 4-arylthiazoles, their preparation, and to their use as therapeutic agents, particularly in the prevention or treatment of tuberculosis. The present invention particularly relates to compounds of formula A: | 2014-08-21 |
20140235864 | BIPHENYL DERIVATIVES - This invention provides biphenyl derivatives of formula I: | 2014-08-21 |
20140235865 | METHOD FOR PRODUCING TETRAZOLE-SUBSTITUTED ANTHRANILIC ACID DIAMIDE DERIVATIVES BY REACTING PYRAZOLIC ACIDS WITH ANTHRANILIC ACID ESTERS - The present invention relates to a process for preparing tetrazole-substituted anthranilic acid diamide derivatives of the formula (1) | 2014-08-21 |
20140235866 | Process to Obtain a Trifluoromethylating Composition - Process to obtain a trifluoromethylating composition which comprises the reaction between a copper (I) source and a base in the presence of a solvent and between the resulting cuprating reagent with fluoroform. | 2014-08-21 |
20140235867 | METHOD FOR PRODUCING ALPHA-HYDROXY KETONE COMPOUND - The present invention relates to a specific thiazolium salt used for producing an α-hydroxy ketone compound, and a method for producing an α-hydroxy ketone compound by carrying out a coupling reaction of an aldehyde compound in the presence of a base compound and the specific thiazolium salt. | 2014-08-21 |
20140235868 | NOVEL ANTITHROMBOTIC AND ANTIATHEROSCLEROTIC AGENT AND METHOD FOR PRODUCING SAME (VARIANTS) - The invention relates to the field of chemical and pharmaceutical industry and medicine and concerns compounds which can be used to produce agents for the treatment of cardiovascular diseases. | 2014-08-21 |
20140235869 | PROCESS FOR THE PREPARATION OF THIETANE DERIVATIVES - The present invention relates to processes for the preparation of thietane derivatives of the formula (IA) and thietane derivatives of the formula (IB) wherein R | 2014-08-21 |
20140235870 | PROCESS FOR PREPARING SAXAGLIPTIN AND ITS NOVEL INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF - Methods of making saxagliptin, pharmaceutically acceptable salts and hydrates thereof and intermediates thereof. | 2014-08-21 |
20140235871 | (S)-4-HYDROXY-2-OXO-1-PYRROLIDINEACETAMIDE RACEMATE CRYSTAL FORM II AND PREPARATION METHOD THEREFOR - An (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide racemate referred to as (S)-oxiracetam crystal form II has a diffraction peak at a diffraction angle 2θ of 10.669, 13.25, 13.847, 14.198, 16.729, 17.934, 18.746, 18.816, 20.273, 20.413, 21.431, 21.617, 21.663, 23.38, 24.324, 24.415, 26.069, 26.107, 27.901, 28.621, 28.925, 29.449, 29.484, 31.702, 36.516, 37.685, or 39.721 degrees. The purity of the (S)-oxiracetam crystal form II can be up to 98.5%, and the (S)-oxiracetam crystal form II has the advantages of simple preparation method, mild control condition, low production cost, and the produced oxiracetam hydrate crystal form II has a high purity (the oxiracetam hydrate crystal form having a purity of 8%˜98.5% can be prepared by a crude levo-oxiracetam having a purity of 92%, and thus having a good reproducibility in production. | 2014-08-21 |
20140235872 | NOVEL LOW MOLECULAR WEIGHT CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY - The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA. | 2014-08-21 |
20140235873 | Process for Producing Ionic Liquids - The present invention provides a method for producing ionic liquids without the use of a volatile solvent and/or water. In some embodiments, methods of the invention allow a continuous process for producing ionic liquids. | 2014-08-21 |
20140235874 | PROCESS FOR THE PREPARATION OF BENZODITHIOPHENE COMPOUNDS - The present invention relates to a process for the preparation of benzodithiophene compounds which comprises reacting a derivative of 3,3′-bithiophene with at least one internal alkyne. Said benzodithiophene compounds can be suitably functionalized and polymerized to give electron-donor compounds which can be used in photovoltaic devices such as, for example, photovoltaic cells, photovoltaic modules, solar cells, solar modules, on both rigid and flexible supports. Furthermore said benzodithiophene compounds can be advantageously used as spectrum converter in luminescent solar concentrators (LSCs). Said benzodithiophene compound can also be advantageously used as precursor of monomeric units in the preparation of semiconductor polymers. | 2014-08-21 |
20140235875 | METHOD FOR PRODUCING CYCLIC CARBONATES - Linear or cyclic carbonates as potential monomers for isocyanate-free polyurethanes and polycarbonates were prepared from polyols and dialkyl carbonates or diphenyl carbonates. This invention was developed to produce linear or cyclic carbonates with or without using catalysts. Polyol compounds were reacted with carbonates such as dimethyl carbonate and diethyl carbonate to produce the corresponding linear and/or cyclic carbonate. | 2014-08-21 |
20140235876 | Photochromic Double-Fused Naphthopyrans - The present invention relates to photochromic double-fused naphthopyrans of the general formula (I) or (II) and the use thereof in plastics of all kinds, particularly for ophthalmic purposes. The photochromic compounds according to the invention are characterized by two distinct absorption bands of the open form in the visible wavelength range, i.e. two conventional photochromic dyes, each having only one discrete absorption band, can be replaced with dye molecules of this type. The compounds according to the invention, moreover, have a very good lifetime with a very high performance. | 2014-08-21 |
20140235877 | COMPOUNDS, METHODS OF PREPARATION AND USE THEREOF FOR TREATING CANCER - The present invention provides two compounds, namely Compound A and B, as the potential anticancer drug, and a composition comprising said Compound A and/or B for treating cancer or tumor related diseases. The present invention also relates to methods of preparing the compounds from a natural source and a composition comprising the compounds, and using the same for treating cancer or tumor related diseases. | 2014-08-21 |
20140235878 | Process for the production of a dioxolane compound from crude glycerol - A process for the production of dioxolane compounds of formula (I): | 2014-08-21 |
20140235879 | ORALLY DISPERSIBLE TABLET - The present invention provides a preparation with improved disintegration property, a preparation showing improved bioavailability of a medicament, production methods thereof and the like. A rapidly disintegrating preparation comprising granules comprising a medicament coated with a coating layer containing sugar or sugar alcohol; and a disintegrant. A production method of a rapidly disintegrating preparation including a step of producing granules comprising a medicament, a step of forming a coating layer containing sugar or sugar alcohol on the obtained granules and a step of mixing the coated granules with a disintegrant and molding the mixture. | 2014-08-21 |
20140235880 | PROCESS FOR PURIFYING CRUDE FURAN 2,5-DICARBOXYLIC ACID USING HYDROGENATION - A process to produce a dry purified furan-2,5-dicarboxylic acid (FDCA) is described. After oxidation of 5-(hydroxymethyl)furfural (5-HMF), a crude FDCA stream is produced that is fed to a crystallization zone followed by a solid-liquid displacement zone to form a low impurity slurry stream. The solids in the low impurity slurry stream are dissolved in a dissolution zone to produce a hydrogenation feed that is hydrogenated in a hydrogenation reactor to generate a hydrogenated FDCA composition. The hydrogenated FDCA composition is routed to a crystallization zone to form a crystallized produce stream that is separated from liquid in a solid-liquid separation zone to generate a purified wet cake stream containing FDCA that can be dried in a drying zone to generate a dry purified FDCA product stream. | 2014-08-21 |
20140235881 | METHOD FOR PRODUCING 5-HYDROXYMETHYL-2-FURFURAL OR ALKYL ETHER DERIVATIVES THEREOF USING AN ION EXCHANGE RESIN IN THE PRESENCE OF AN ORGANIC SOLVENT - The present invention relates to a method for producing a furan-based compound using an ion exchange resin in the presence of an organic solvent. In the method for producing a furan-based compound according to the present invention, a furan-based compound is made from an aldose-type hexose compound in the presence of an organic solvent by using an anion exchange resin and a cation exchange resin. Thus, the aldose-type hexose compound obtained from biomass by simultaneously or consecutively using the anion/cation exchange resins as catalysts can be made into 5-hydroxymethyl-2-furfural (HMF) or alkyl ether derivatives thereof such as 5-alkoxymethyl-2-furfural (AMF) without using an expensive reagent. Also, since the selection of an organic solvent is not limitative and a heterogeneous catalyst can be used, separation and purification is easy and chemically stable AMF can be directly obtained. Further, the conversion efficiency of the aldose-type hexose compound is excellent, and the hexose compound can be used at a high concentration. | 2014-08-21 |
20140235882 | PROCESS FOR THE PREPARATION OF ESTETROL - The present invention relates to a process for the preparation of estra-1,3,5(10)-trien-3,15α,16α,17β-tetraol (estetrol), via a silyl enol ether derivative 17-B-oxy-3-A-oxy-estra-1,3,5(10),16-tetraene, wherein A is a protecting group and B is —Si(R | 2014-08-21 |
20140235883 | ELECTRIC DOUBLE LAYER CAPACITOR MATERIAL - A material for constituting an electric double layer capacity that is stable at high temperatures and can expect a high electric capacity is provided. Such a material is an electric double layer capacitor material which is used as a material for constituting solid electrolytes | 2014-08-21 |
20140235884 | METHOD OF PREPARING SILICON NANOCRYSTALS - The present application includes a method of preparing silicon nanocrystals (Si-NCs) comprising combining silica particles with magnesium and heating said combination under conditions to form Si-NCs, wherein the silica particles are obtained using sol gel chemistry. | 2014-08-21 |
20140235885 | COPOLYMERS OF EPOXY COMPOUNDS AND AMINO SILANES - A composition includes a non-crosslinked reaction product of an oxirane or oxetane compound (I) comprising at least two oxirane or oxetane groups; a compound (II) comprising silicon and one or more amino groups; and optionally a polyamine (III); and a secondary amine (IV). | 2014-08-21 |
20140235886 | PHOSPHORUS-BASED (METH)ACRYLATE COMPOUND AND METHOD OF PREPARING THE SAME - This invention relates to a novel compound having high refractive index suitable for use in optical resin materials, etc., without containing a sulfur atom, and to a method of preparing the same, in which the compound is a phosphorus-based (meth)acrylate compound represented by Formula (I). | 2014-08-21 |
20140235887 | PROCESS FOR MAKING NITRILES - The present invention relates to a process for hydrocyanating 3-pentenenitrile. The process can include feeding 3-pentenenitrile and HCN to a hydrocyanation reaction zone that includes a Lewis acid promoter, nickel, and a phosphorus-containing ligand. In various embodiments, the process can also include controlling water concentration within the hydrocyanation reaction zone sufficient to maintain a high activity of the ligand catalyst complex while recycling at least a portion of the ligand catalyst complex. | 2014-08-21 |
20140235888 | (Z)-2-CYANO-3-HYDROXY-BUT-2-ENOIC ACID-(4'-TRIFLUORMETHYLPHENYL)-AMIDE TABLET FORMULATIONS WITH IMPROVED STABILITY - The invention relates to solid pharmaceutical compositions comprising (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4′-trifluoromethylphenyl)-amide, as well as a process for the preparation of the same, methods of using such compositions to treat subjects suffering from autoimmune diseases in particular systemic lupus erythematosus or chronic graft-versus-host disease, multiple sclerosis or rheumatoid arthritis. | 2014-08-21 |
20140235889 | METHOD FOR PRODUCING BICYCLIC OR TRICYCLIC (METH)ACRYLATES - Process for preparing bicyclic or tricyclic (meth)acrylates by reacting (meth)acrylic acid with a bicyclic or tricyclic hydrocarbon which contains at least one double bond using montmorillonite as catalyst. | 2014-08-21 |
20140235890 | Copper-Zirconia Catalyst and Method of use and Manufacture - Catalysts and methods for their manufacture and use for the dehydrogenation of alcohols are disclosed. The catalysts and methods utilize a highly dispersible alumina, for example, boehmite or pseudoboehmite, to form catalysts that exhibit high dehydrogenation activities. Specifically, the catalysts include Cu that is highly dispersed by reaction of an alumina formed by peptizing of boehmite or pseudoboehmite and precursors of ZrO2, ZnO and CuO. | 2014-08-21 |
20140235891 | USE OF ORGANIC FRAMEWORK POROUS SOLID ACID - The invention relates to an application of organic framework porous solid acid. A catalyst for catalytic esterification and acylation reaction is prepared by the steps of adding a divinyl benzene monomer into a solvent prepared by mixing azobisisobutyronitrile, tetrahydrofuran and water, performing hydrothermal treatment at the normal temperature under the constant pressure, and volatilizing the solvent at the room temperature to obtain polydivinylbenzene; grinding the polydivinylbenzene into 200-mesh powder and performing degassing treatment under the nitrogen condition; adding polydivinylbenzene blocks into 1,1′,2-methyl chloroform to explode and crack into small blocks, wherein the small blocks swell; evenly mixing 1,1′,2-methyl chloroform and concentrated sulfuric acid, adding silver sulfate serving as a catalyst, adding processed polydivinylbenzene, performing sulfonation, filtering and washing with dioxane and water till it is neutral, performing drying, using dilute sulphuric acid to activate, performing washing till the it is neutral and performing drying. The catalyst is used for the catalytic esterification and the acylation reaction and has high catalytic activity and conversion rate. | 2014-08-21 |
20140235892 | PROCESS FOR THE PREPARATION OF A BENZENE DERIVATIVE - A substituted benzene derivative is prepared in a process, which includes
| 2014-08-21 |
20140235893 | Catalyst for Selectively Producing Acetic Acid Through the Partial Oxidation of Ethane - The invention relates to the development of a catalyst for selectively producing acetic acid from a gaseous feedstock of ethane, ethylene or mixtures thereof and oxygen at a low temperature. Said gaseous feedstock is brought together with a catalyst containing the oxides of Mo, V and Nb and nano metallic Pd optionally together with a hetero-poly acid and/or Sb and Ca. The present catalytic system provides both higher selectivity and yield of acetic with minimal production of side products of ethylene and CO. | 2014-08-21 |
20140235894 | METHOD FOR PRODUCING ALPHA,BETA-UNSATURATED CARBOXYLIC ACID-N,N-DISUBSTITUTED AMIDE AND METHOD FOR PRODUCING 3-ALKOXYCARBOXYLIC ACID-N,N-DISUBSTITUTED AMIDE - The invention is directed to a technique for effectively producing an amide compound suitable for use as a solvent or a detergent on a large scale and at low cost. | 2014-08-21 |
20140235895 | PREPARATION OF FINGOLIMOD AND ITS SALTS - The present application provide processes for the preparation of fingolimod and its pharmaceutically acceptable salts, process for the purification of fingolimod hydrochloride and process for the preparation of amorphous fingolimod hydrochloride. | 2014-08-21 |
20140235896 | NOVEL DIAMINE COMPOUND - The present invention provides a novel diamine compound represented by formula (1) below. A in formula (1) denotes an optionally-substituted divalent aliphatic group (having a carbon number of 10 or less) or an optionally-substituted divalent aromatic group (having the number of rings of 4 or less), for example. The diamine compound of the present invention can be used as a raw material or a crosslinking agent for polyamide, polyimide, polyurethane, epoxy resin, etc. | 2014-08-21 |
20140235897 | PROCESS FOR OXIDIZING ONE OR MORE THIOL COMPOUNDS - One exemplary embodiment can be a process for oxidizing one or more thiol compounds from an alkaline stream. The process may include passing a mixed stream having the alkaline stream to an oxidation vessel having a body and a neck. Often, the body contains one or more packing elements and the neck contains a packing, a distributor, and a mesh. The process can further include passing an oxidized alkaline stream to a separation vessel containing a first chamber and a second chamber. Usually, the first chamber contains a coated mesh. | 2014-08-21 |
20140235898 | Substituted Phenylsulfur Trifluoride and Other Like Fluorinating Agents - Novel substituted phenylsulfur trifluorides that act as fluorinating agents are disclosed. Also disclosed are methods for their preparation and methods for their use in introducing one or more fluorine atoms into target substrate compounds. Finally, various intermediate compounds for use in preparing substituted phenylsulfur trifluorides are provided. | 2014-08-21 |
20140235899 | COMPOUNDS AND METHODS FOR PREPARATION OF DIARYLPROPANES - Compounds of structure (I): | 2014-08-21 |
20140235900 | METHOD AND APPARATUS FOR THE REMOVAL OF POLYVALENT CATIONS FROM MONO ETHYLENE GLYCOL - The invention relates to a method and an apparatus for the removal of polyvalent cations, in particular divalent cations, from mono ethylene glycol. Mono Ethylene Glycol (MEG) is used to prevent hydrate formation in pipelines transporting gas, condensate and water. It may also contribute to pipeline corrosion control. The invention describes a method for the removal of polyvalent cations from mono ethylene glycol, comprising providing a feed of aqueous mono ethylene glycol comprising dissolved gas and salts of divalent cations (rich MEG), heating the aqueous mono ethylene glycol to a heated mixture, causing precipitation of at least part of the salts and release of at least part of the dissolved gas, in particular carbon dioxide, separation of released gas from the mono ethylene glycol, separation of at least part of the precipitated salts from the mono ethylene glycol, distillation of at least part of the water from the heated mixture, to yield hot dewatered mono ethylene glycol (lean MEG), wherein a first part of the hot dewatered mono ethylene glycol is lead back to the aqueous mono ethylene glycol feed to provide at least part of the heat for heating the aqueous mono ethylene glycol. | 2014-08-21 |
20140235901 | Production of Higher Alcohols - A reactive distillation method comprises introducing a feed stream to a reactive distillation column, contacting the feed stream with one or more catalysts in the reactive distillation column during a distillation, and removing one or more higher alcohols during the distillation from the reactive distillation column as a bottoms stream. The feed stream comprises one or more alpha hydrogen alcohols, and the feed stream reacts in the presence of the one or more catalysts to produce a reaction product comprising the one or more higher alcohols. | 2014-08-21 |
20140235902 | Method for preparing a mixture of alcohols - A method for preparing a mixture (M) comprising at least an alcohol (Aj), said method comprising the following steps: i) a step in which at least an alcohol (Ai) in gaseous state is oligomerized, thereby producing a mixture (A); ii) a step in which the mixture (A) is condensed to a gaseous stream and to a liquid stream corresponding to a condensed mixture (A); and iii) a step in which the condensed mixture (A) is hydrogenated in the liquid state. | 2014-08-21 |
20140235903 | PROCESS FOR PRODUCING 2,3,3,3-TETRAFLUOROPROPENE - The present invention relates, in part, to the discovery that the presence of impurities in a reactor for dehydrochlorinating HCFC-244bb to HFO-1234yf results in selectivity changeover from HFO-1234yf to HCFO-1233xf. By substantially removing such impurities, it is shown that the selectivity to HFO-1234yf via dehydrochlorination of HCFC-244bb is improved. | 2014-08-21 |
20140235904 | PROCESS FOR PRODUCING 2,3,3,3-TETRAFLUOROPROPENE - The present invention relates, in part, to the discovery that high temperatures during the fluorination of 1,1,2,3-tetrachloropropene (HCO-1230xa) to 2-chloro-3,3,3-trifluoropropene (HCFO-1233xf) results in catalyst instability, reduced selectivity of the conversion, and/or the formation of one or more undesirable by-products. By controlling the reaction temperature, it is shown that the catalyst life may be extended and the selectivity of the reaction improved. Such control similarly results in an overall improvement in the production of certain hydrofluoroolefins, particularly 2,3,3,3-tetrafluoropropene (HFO-1234yf). | 2014-08-21 |
20140235905 | METHOD FOR THE SYNTHESIS OF LOW COST INITIATORS FOR TELECHELIC POLYISOBUTYLENES - A method for the synthesis of 1,3-di(chloropropyl)-5-tert-butyl benzene includes the steps of conducting Friedl-Crafts alkylation of 1,3-diisopropyl benzene by tert-butyl chloride in the presence of an alkylation catalyst to obtain 1-tert-butyl-3,5-diisopropylbenzene; peroxidizing the 1-tert-butyl-3,5-diisopropyl benzene by gaseous oxygen in the presence of a peroxidation catalyst in a basic solution to obtain 1,3-di(peroxypropyl)-5-tert-butylbenzene; reducing the 1,3-di(peroxypropyl)-5-tert-butylbenzene with a reducing agent to 1,3-di(hydroxyl propyl)-5-tert-butylbenzene; and chlorinating the 1,3-di(hydroxypropyl)-5-tert-butylbenzene to obtain 1,3-di(chloropropyl)-5-tert-butyl benzene. | 2014-08-21 |
20140235906 | PROCESS TO MAKE 1,1,2,3-TETRACHLOROPROPENE FROM 1,1,3-TRICHLOROPROPENE AND/OR 3,3,3- TRICHLOROPROPENE - Disclosed is a process for the synthesis of 1,1,2,3-tetrachloropropene (HCC-1230xa) using 1,1,3-trichloropropene (HCC-1240za) and/or 3,3,3-trichloropropene (HCC-1240zf) and Cl | 2014-08-21 |
20140235907 | METHODS FOR THE DEHYDROCHLORINATION OF 1,1,1,3-TETRACHLOROPROPANE TO 1,1,3-TRICHLOROPROPENE - This invention relates to a method to improve 1,1,3-trichloropropene selectivity in HCC-250fb (1,1,1,3-tetrachloropropane) dehydrochlorination. In normal practice, FeCl | 2014-08-21 |
20140235908 | SWITCHABLE HYDROPHILICITY SOLVENTS AND METHODS OF USE THEREOF - A solvent that reversibly converts from a hydrophobic liquid form to hydrophilic liquid form upon contact with water and a selected trigger, e.g., contact with CO | 2014-08-21 |
20140235909 | 1-DECENE/1-DODECENE COPOLYMER AND LUBRICATING-OIL COMPOSITION CONTAINING SAME - Provided are an α-olefin copolymer useful as a high-viscosity lubricant oil excellent in viscosity characteristics, low-temperature characteristics and oxidation stability, and a lubricant oil containing the copolymer. The α-olefin copolymer is a 1-decene/1-dodecene copolymer produced by the use of a doubly bridged metallocene catalyst. | 2014-08-21 |
20140235910 | INTEGRATED PROCESS FOR THE PRODUCTION OF BIOFUELS FROM SOLID URBAN WASTE - Integrated process for the production of biofuels from solid urban waste which comprises:
| 2014-08-21 |
20140235911 | CATALYST FOR THE PREPARATION OF AROMATIC HYDROCARBONS AND USE THEREOF - The present invention relates to catalyst composition comprising lanthanum and gallium containing zeolite and lanthanum modified binder, wherein said lanthanum and gallium containing zeolite comprises about 0.01-0.1 wt-% lanthanum and wherein said lanthanum modified binder comprises about 0.5-2 wt-% lanthanum. Furthermore, the present invention relates to a method for preparing the catalyst composition of the present invention and a process for producing aromatic hydrocarbons comprising contacting a feedstream comprising lower alkanes with the catalyst composition of the present invention under conditions suitable for alkane aromatization. | 2014-08-21 |
20140235912 | METHOD FOR OBTAINING BRANCHED ALKANES AND AROMATIC HYDROCARBONS - A method for the recovery of energy from synthesis gas waste products obtained from wet crushed coal, according to a gasification-pyrolysis process, which comprises the submission of the waste products obtained during the production of the synthesis gas to a subsequent treatment, to transform such products into other products of the branched-chain alkane type and aromatic compounds, recovering the hydrogen obtained during these reactions, which will be available to be used at other chemical processing plants, as fuel or simply to be fed back to the gasification-pyrolysis process itself, to enrich the synthesis gas obtained. | 2014-08-21 |
20140235913 | PROCESS FOR METATHESIS OF OLEFINS OBTAINED FROM FISCHER-TROPSCH FRACTIONS USING A RUTHENIUM COMPLEX COMPRISING A SYMMETRIC N-HETEROCYCLIC DIAMINOCARBENE - This invention describes a process for metathesis of olefins from feedstocks obtained from the Fischer-Tropsch process, using as catalyst a ruthenium indenylidene complex comprising a saturated or unsaturated, symmetric N-heterocyclic carbene. | 2014-08-21 |
20140235914 | Eggshell Catalyst Composites Containing Tungsten Oxide or Tungsten Oxide Hydrate - Provided are catalyst composites useful for the production of olefins during a metathesis reaction, as well as methods of making and using the same. Certain methods comprise a support comprising at least about 90% by weight silica; and an eggshell layer on the support comprising about 0.25 to about 10 wt. % tungsten in the form of tungsten oxide or tungsten oxide hydrate, based on the total weight of the catalyst composite. | 2014-08-21 |
20140235915 | PROCESS FOR SULFUR REMOVAL FROM REFINERY OFF GAS - Organic sulfur compounds contained in refinery off gas streams having either high ort low concentrations of olefins are converted to hydrogen sulfides which can be then be removed using conventional amine treating systems. The process uses a catalytic reactor with or without a hydrotreater depending on the olefin concentration of the off gas stream. The catalytic reactor operates in a hydrogenation mode or an oxidation mode to convert a majority of organic sulfur compounds into hydrogen sulfides. | 2014-08-21 |
20140235916 | METHOD FOR REMOVING RADIOACTIVE CESIUM, HYDROPHILIC RESIN COMPOSITION FOR REMOVAL OF RADIOACTIVE CESIUM, METHOD FOR REMOVING RADIOACTIVE IODINE AND RADIOACTIVE CESIUM, AND HYDROPHILIC RESIN COMPOSITION FOR REMOVAL OF RADIOACTIVE IODINE AND RADIOACTIVE CESIUM - A method for removing radioactive cesium and/or iodine from a radioactive substance in liquid and/or a solid matter using a hydrophilic resin composition comprising a hydrophilic resin and a metal ferrocyanide compound, wherein the hydrophilic resin includes at least one hydrophilic resin selected from the group consisting of a hydrophilic polyurethane resin, a hydrophilic polyurea resin, and a hydrophilic polyurethane-polyurea resin each having at least a hydrophilic segment, and a metal ferrocyanide compound is dispersed in the hydrophilic resin composition in a ratio of at least 1 to 200 mass parts relative to 100 mass parts of the hydrophilic resin. | 2014-08-21 |
20140235917 | PHARMACEUTICAL DISPOSAL DEVICE AND METHOD - A device for disposing unused pharmaceuticals including a container having sealing means, a superabsorbent polymer arranged in the container in a loose orientation, a deterrent compound, and optionally a dye. The device is adapted so that after pharmaceuticals and a fluid substance are added to the container, and the container is sealed, the container can be agitated (e.g., shaken) to enable the superabsorbent polymer to absorb the fluid and congeal in order to nearly instantaneously form a gel structure, which completely or nearly completely envelops the pharmaceuticals in the container. The deterrent compound can break down and/or denature the pharmaceuticals enveloped in the gel structure. The container may then be disposed of in a conventional household garbage container. The dye provides a visual warning that the pharmaceuticals should not be consumed and the repellant compound provides an unpleasant flavor and/or smell which deters ingestion of the pharmaceuticals. | 2014-08-21 |
20140235918 | LASER ION SOURCE AND HEAVY PARTICLE BEAM THERAPY EQUIPMENT - One embodiment of a particle accelerator includes: a vacuum container with its inside evacuated to produce vacuum, the vacuum container being formed with a laser beam entrance window for allowing a laser beam to enter; a target arranged in the vacuum container so as to be irradiated with a laser beam to generate ions; and a condenser lens for focusing the laser beam onto the target. The condenser lens is arranged at the laser beam entrance window of the vacuum container, and takes a role of a vacuum bulkhead. | 2014-08-21 |
20140235919 | MULTI-LEAF COLLIMATOR, PARTICLE BEAM THERAPY SYSTEM, AND TREATMENT PLANNING APPARATUS - There are provided a leaf row in which a plurality of leaf plates are arranged in the thickness direction of the row in such a way that the respective one end faces of the leaf plates are trued up and a leaf plate drive mechanism that drives each of the plurality of leaf plates in such a way that the one end face approaches or departs from a beam axis. In each of the leaf plates, a facing side facing a leaf plate that is adjacent to that leaf plate in the thickness direction is formed of a plane including a first axis on the beam axis; the leaf plate drive mechanism drives the leaf plate along a circumferential orbit around the second axis, on the beam axis, that is perpendicular to the beam axis and the first axis. | 2014-08-21 |
20140235920 | Radiosurgical Neuromodulation Devices, Systems, and Methods for Treatment of Behavioral Disorders by External Application of Ionizing Radiation - Radiosurgical techniques and systems treat behavioral disorders (such as depression, Obsessive-Compulsive Disorder (“OCD”), addiction, hyperphagia, and the like) by directing radiation from outside the patient toward a target tissue within the patient's brain, typically without imposing surgical trauma. The target will often be included in a neural circuit associated with the behavioral disorder. A cellularly sub-lethal dose of the radiation may be applied and the radiation can mitigate the behavioral disorder, obesity, or the like, by modulating the level of neural activity within the target and in associated tissues. Hypersensitive and/or hyperactive neuronal tissue may be targeted, with the radiation downwardly modulating hyperactive neuronal activity. By down-regulating the activity of a target that normally exerts negative feedback or a limiting effect on a relevant neural circuit, the activity of the circuit may be increased. | 2014-08-21 |
20140235921 | SYSTEM AND METHOD FOR POSITIONING WITH NUCLEAR IMAGING - The invention relates to a system for determining the position of radioactively marked target tissue of a patient in radiation therapy by means of a radiation therapy device. The system comprises at least one detector for the imaging detection of the radiation distribution of a radioactive radiation source that is located in target tissue region, a computing unit that is designed to calculate the pose of the target tissue region from measurement data of the detector and to calculate a correction variable as the difference between the calculated pose and comparison values, and an interface by means of which the data for the calculated pose of radioactively marked target tissue region and the correction variable can be transmitted by the computing unit to a radiation therapy device or a patient positioning device. The invention further relates to a corresponding method. | 2014-08-21 |