34th week of 2022 patent applcation highlights part 30 |
Patent application number | Title | Published |
20220267694 | LOW POUR POINT DERIVATIVES OF DIMER FATTY ACIDS - The present invention relates to specific derivatives of dimer fatty acids, compositions comprising them and a method to reduce pour points. | 2022-08-25 |
20220267695 | METHOD OF MAKING A GREASE THICKENER AND THE THICKENER MADE BY THE METHOD - A continuous process for producing a polyurea concentrate or powder. The process includes combing at least one amine and an isocayante in the presence of a liquid diluent or a base oil in a rotor stator mixer. The concentrate comprises a polyurea in a base oil wherein the concentration of from about 20 weight percent to about 50, or 40 or 35 or 30 weight percent of polyurea based on total weight of grease thickener. The powder has particle size of 2 to 400 microns. This concentrate or powder can then be formulated by grease manufacturers to the desired final properties without the need for handling of the isocyanate and amine raw materials. | 2022-08-25 |
20220267696 | METHOD FOR OPERATING REFRIGERANT CIRCULATION SYSTEM - A method for operating a refrigerant circulation system comprising a compressor, a condenser, an expansion mechanism, and an evaporator connected in this order with piping, wherein a refrigerant comprising trifluoroiodomethane is used as a refrigerant; a refrigerating machine oil comprising, as a base oil, a polyolester synthesized from a polyhydric alcohol and fatty acids, with a proportion of a fatty acid having 9 carbon atoms in the fatty acids being 65 mol % or less is used as a refrigerating machine oil; and a temperature of an entire area of the refrigerant circulation system is kept at 160° C. or lower. | 2022-08-25 |
20220267697 | METHOD FOR THE SEPARATE EXTRACTION OF RICE BRAN OIL AND RICE BRAN WAXES - A method for the separate extraction of rice bran oil and rice bran wax using supercritical CO | 2022-08-25 |
20220267698 | COMPOSITIONS FOR CLEANING AND DECONTAMINATION - Provided among other things is a cleaning composition comprising: a carrier fluid; and Minute Fibrils suspended in the carrier fluid, wherein the composition is protein cleaning effective. | 2022-08-25 |
20220267699 | PEPTIDE ACETALS FOR STABILISING ENZYMES - The present invention relates to a compound for stabilizing enzymes, the use of said compound for stabilizing an enzyme, a composition comprising said compound, a method of preparing the composition comprising said compound, a detergent composition comprising said compound and a method of preparing said compound. | 2022-08-25 |
20220267700 | METHOD AND SYSTEM FOR PRODUCING ULTRA-HIGH GRAVITY ALCOHOLIC BEVERAGES USING AN ENHANCED DRAW SOLUTION - Methods and systems are described that produce an ultra-high gravity alcoholic beverage from a high gravity alcoholic beverage stream using an efficient, low waste, combination reverse osmosis and forward osmosis system and an enhanced draw solution. Utilizing a reverse osmosis system prior to using a forward osmosis system in removing water content from a high gravity alcoholic beverage stream significantly reduces a draw solution load when compared to a process that utilizes a forward osmosis system alone or prior to using any other dewatering system. In addition, the enhanced draw solution, comprising at least one of acetaldehyde, amyl acetate, ethyl acetate, ethyl hexanoate, ethyl octanoate, iso-amyl acetate, iso-amyl alcohol, iso-butanol, n-propanol, pentyl acetate, and phenyl ethyl alcohol, offers an efficient and low-cost alternative to ethanol-based draw solutions. | 2022-08-25 |
20220267701 | IMPROVEMENTS IN BREWING - An apparatus for brewing and dispensing a beverage comprising a fermentation container for containing and fermenting a beverage, the fermentation container comprising a first outlet, and a collector for collecting waste from the fermentation container, the collector being attachable to and detachable from the fermentation container at the first outlet. | 2022-08-25 |
20220267702 | Systems and Methods for the Preparation of Ethanol-Containing Beverages Using Microorganisms - The present inventive concept relates generally to simulating the barrel aging or finishing process of alcohol-containing products in a rapid manner using various microorganisms to impart flavors and aromas during the aging or finishing process. Products and methods used in the process of aging or finishing the alcohol-containing products are also provided. | 2022-08-25 |
20220267703 | DEVICE FOR OBSERVING A LIVING CELL OR A SET OF LIVING CELLS - The present invention relates to an imaging device for observing the development of a living cell or a set of living cells such as embryos, comprising a lighting system, means for relative displacement and an imaging system equipped with a wide-field camera which is adapted to allow the identification, the imaging and the observation of one or more living cells or sets of living cells to be observed. The invention also relates to a method for observing the development of embryos by means of such a device. | 2022-08-25 |
20220267704 | CELL PRESERVATION OR TRANSPORTATION INSTRUMENT AND CELL TRANSPORATION METHOD - An object of the present invention is to provide a transportation instrument and a transportation method that enable transportation by using a cell culture container as it is. Further, an object of the present invention is to provide a transportation instrument and a transportation method that enable supply of oxygen required for respiration of cells. Further, an object of the present invention is to provide a transportation instrument and a transportation method that enable suppression of migration of a culture medium into and out of cells caused by the influence of an increase in internal pressure with respect to the temperature during transportation. According to the present invention, provided is a cell preservation or transportation instrument including a plurality of cell storage containers, a plate which has a plurality of recesses for holding the plurality of cell storage containers therein, and a flexible material sheet which seals upper opening portions of the plurality of cell storage containers and upper side wall portions formed by side walls of the recesses of the plate and allows ventilation between an inside and an outside of the plurality of cell storage containers. | 2022-08-25 |
20220267705 | CO-CULTURE APPARATUS, CO-CULTURE SYSTEM, AND CO-CULTURE METHOD - A co-culture apparatus includes: a first airtight container; a co-culture device disposed outside of the first airtight container; a first culture medium source disposed in the first airtight container and storing a first culture medium; a second culture medium source storing a second culture medium having a lower dissolved oxygen concentration than that of the first culture medium; and a first conduit connected to the co-culture device and the first culture medium source. The co-culture device includes: a membrane having a first main surface, and a second main surface opposite to the first main surface for culturing cells; a first flow path partially defined by the first main surface and disposed such that the first culture medium flows therethrough; and a second flow path partially defined by the second main surface and disposed such that the second culture medium flows therethrough. The first flow path has an inlet connected to the first conduit. | 2022-08-25 |
20220267706 | SHEET-SHAPED CELL CULTURE PREPARATION DEVICE - A device including a mixing bag for mixing liquids, a cell-suspension bag fluidly connected to the mixing bag, a diluent bag fluidly connected to the mixing bag, and a fluidly connected to the mixing bag is capable of easily preparing a sheet-shaped cell culture without requiring any large-scale equipment. The sheet-shaped cell culture can be aseptically prepared by the device, while reducing the risk of contamination, by using the mixing bag which is fluidically connected to the other bags. The device includes a support having a foldable structure. At least one of the cell-suspension bag, the diluent bag and the filter is fixed to various portions of the support. The device can be folded into a compact size, by folding the various portions of the support, allowing for efficient transportation and storage. | 2022-08-25 |
20220267707 | HANGING DROP DEVICE, FORMATION METHOD OF HANGING DROP AND CELL CULTURE METHOD BY USING HANGING DROP - A hanging drop device is provided in the present disclosure. The hanging drop device includes a hanging drop box and a negative pressure module. The hanging drop box includes a plate and a cover. The cover is coupled with the plate to jointly delimit a pressure chamber. The cover includes an upper surface and a bottom surface, a plurality of wells are recessed from the upper surface, and each of the wells is communicated with the pressure chamber through a hole. The negative pressure module is communicated with the pressure chamber. Each of the wells is for containing a liquid, the negative pressure module is for generating a negative pressure in the pressure chamber, so as to drive the liquid in each of the wells to pass through the hole, and the liquid forms a hanging drop hanging from the bottom surface of the cover. | 2022-08-25 |
20220267708 | STIRRING DEVICE WITH A SHAFT, ADAPTED TO BE MOUNTED IN A FLUID-MIXING BIOREACTOR, AND METHOD FOR ASSEMBLING A STIRRING DEVICE - The stirring device, in particular for a fluid-mixing bioreactor, comprises a drive shaft including a rod, an agitating element and a sleeve of tubular shape. The sleeve forms a coupling sleeve receiving the shaft therethrough and is directly rotationally coupled to the rod. The agitating element, which has a hub with an annular side wall delimiting an inner space and an impeller assembly comprising blades, is indirectly rotationally coupled to the rod via the sleeve that is engaged in the inner space. One of an inner surface of the wall and an outer surface of the sleeve is a guiding surface with progressively reduced cross section. Axial movement between the hub and the sleeve is prevented in a locked configuration of a sleeve fastening arrangement. Hub-sleeve contact areas can be axially distributed. | 2022-08-25 |
20220267709 | PHYSICAL MANIPULATION OF TISSUE CULTURED TISSUE - The disclosure relates to methods, systems and compositions for physically manipulating a muscle tissue culture either mechanically, or manually, or both. Specifically, the disclosure relates to systems and methods of physically manipulating, either mechanically or manually, a resilient container of bioprinted tissue culture having non-random three dimensional cell structure by elongation, compression, torque and shear of the tissue culture. | 2022-08-25 |
20220267710 | CELL COLLECTING APPARATUS, CELL COLLECTING METHOD, AND COMPUTER-READABLE MEDIUM - A cell collecting apparatus includes: a culturing device having a culture vessel and a collecting channel; and a control device. The culturing device cultures cells in a state where the cells are suspended in a liquid medium stored in the culture vessel. The control device controls the culturing device such that a suspension height, which is a height at which the target cell is suspended in the liquid medium, approaches a collection height, which is a height of an inlet of the collecting channel, the inlet configured to be used for cell collection from inside the culture vessel. | 2022-08-25 |
20220267711 | COMPONENT RECOVERY MECHANISM, COMPONENT RECOVERY CONTAINER, COMPONENT RECOVERY KIT, COMPONENT RECOVERY SYSTEM, CULTURE CONTAINER, CULTURE SYSTEM, AND METHOD OF PRODUCING CELLS - A component recovery mechanism includes a recovery unit configured to recover a component for recovery from a target, and a diffusion adjustment unit configured to adjust a diffusion rate of the component for recovery from the target to the recovery unit. The diffusion adjustment unit changes the diffusion rate of the component for recovery from the target to the recovery unit according to a change in at least one environmental parameter. | 2022-08-25 |
20220267712 | CELL ISOLATION FOR USE IN AUTOMATED BIOREACTORS - The present disclosure provides cassettes for use in automated cell engineering systems that include cell separation filters for capturing a target cell population for automated processing. The disclosure also provides methods of separating a target cell population, as well as automated cell engineering systems using the cassettes and for carrying out the methods. | 2022-08-25 |
20220267713 | METHOD FOR PRODUCING VIRUS AND HARVEST LIQUID COMPOSITION - The present invention provides a method for producing a virus and a harvesting solution composition. The method includes culturing cells, wherein the cells have been inoculated with viruses or have been transfected with viral packaging elements; and contacting the cultured cells with a harvesting solution composition to harvest the viruses by one-step, wherein the harvesting solution composition comprises a trypsin, a pH buffer and optionally a nuclease, and the pH of the harvesting solution composition is greater than 7.5 and no more than 10.5. The virus production method of the present invention has advantages of simple operation, easy scale-up, stable yield and so on, and the yield is unexpectedly and significantly improved compared to the prior art, and it can ensure the integrity of the viral particles without damaging the biological activity of the viruses. Therefore, it is very suitable for large-scale production of viruses. | 2022-08-25 |
20220267714 | METHOD OF OBTAINING MITOCHONDRIA FROM CELLS AND OBTAINED MITOCHONDRIA - The present disclosure relates to methods of obtaining mitochondria from cells, mitochondria obtained by such methods, and uses of mitochondria obtained by such methods. | 2022-08-25 |
20220267715 | METHOD FOR MICROALGAL CULTIVATION - Disclosed is a method for microalgal cultivation. The method includes cultivating a microalgal species in a medium in an autotrophic mode for a predetermined first time period where light is supplied and supplying an organic carbon source to the medium to cultivate the microalgal species in a heterotrophic mode for a predetermined second time period where the supply of light is stopped. | 2022-08-25 |
20220267716 | METHODS AND COMPOSITIONS FOR CULTURING HEMOGLOBIN-DEPENDENT BACTERIA - Provided herein are methods and compositions related to culturing hemoglobin-dependent bacteria. | 2022-08-25 |
20220267717 | METHOD FOR PREPARING PURE PLANT-BASED MICROBIAL CULTURE - The present invention relates to a method for preparing a pure plant-based microbial culture, and provides: an application of a culture technology using both plant-derived juice and dietary fiber materials; and a culture and processing process for processing plant-derived vitamins and functional polysaccharides in a usable form, and adsorbs a microbial culture on a pure plant-based dietary fiber so as to maximally inhibit use in the oral cavity and digestive organs by harmful bacteria and selectively utilize microbial culture for the growth of beneficial bacteria, and thus, the present invention forms beneficial bacteria-oriented microcosms by strongly inducing the selective growth of beneficial bacteria preferentially in microcosms in the oral cavity and digestive organs. | 2022-08-25 |
20220267718 | BACTERIAL-BASED MODULATION OF PLANT GROWTH - Disclosed herein are bacterial strains and products thereof, and uses thereof for example to increase, improve or facilitate plant growth. Also disclosed herein are method to increase or improve plant tolerance or resistance to one or more abiotic stress conditions. | 2022-08-25 |
20220267719 | METHOD FOR LOADING OF MICROORGANISMS ON MULTIPHASE BIOMATERIALS - The invention relates to method for loading microorganisms or parts thereof on and/or in pre-synthesized multiphase biomaterials comprising nanocellulose wherein the microorganisms are resuspended in a buffer or a culture medium and loaded into and/or onto the multiphase biomaterial and the use of such a loaded multiphase biomaterial in nutritional, food, pharmaceutical, medical, cosmetic, especially oral, mucosal, dermal and transdermal, ocular, dermatological or female health applications. | 2022-08-25 |
20220267720 | FIBROSIS-SPECIFIC CELL CULTURE SUBSTRATE AND METHODS OF USE - An in vitro cell culture substrate is disclosed. The substrate comprises a decellularized tissue-specific extracellular matrix, wherein the tissue-specific extracellular matrix is derived from fibrotic tissue. A method of method of assessing an in vitro fibrotic cell culture is also disclosed. The method comprises providing one or more substrates comprising decellularized tissue-specific extracellular matrix derived from fibrotic tissue, where each substrate is provided in segregated manner. The method further comprises culturing native cells in each substrate to form a fibrotic cell culture. The method further comprises assessing at least one characteristic of each fibrotic cell culture. | 2022-08-25 |
20220267721 | SYSTEMS AND METHODS FOR EXTRACTING AND ISOLATING PURIFIED WHEAT EMBRYO PRODUCTS - Methods for producing a purified wheat embryo product are disclosed. In one embodiment, producing a purified wheat embryo product includes the steps of: accelerating a plurality of wheat berries toward an impact surface, impacting each of the plurality of wheat berries against the impact surface, dislodging at least some of the wheat embryos from the wheat berries in response to the impacting step such that the dislodged embryos are intact, and separating the dislodged wheat embryos from the bran and the endosperm to produce an intermediate purified wheat embryo product. | 2022-08-25 |
20220267722 | Improved Retinal Organoids And Methods Of Making The Same - The present invention relates to methods for making in vitro retinal cultures, tissue, or retinal organoids, from pluripotent cells as well as the improved synthetic retinal tissue and retinal organoids themselves. It also relates to retinal organoids that replicate in vitro many characteristics of the retina (e.g., human or mammalian), and methods of using this retinal organoid to study disease and to identify therapeutic agents for the treatment of retinal diseases and disorders. | 2022-08-25 |
20220267723 | METHODS FOR DIFFERENTIATING PLURIPOTENT STEM CELLS IN DYNAMIC SUSPENSION CULTURE - Methods for differentiating pluripotent stem cells to neuroectoderm in dynamic suspension culture using small molecule or protein inhibitors of TGFβ/Activin/Nodal signaling and BMP signaling are provided. Also provided are methot and protocols for differentiating pluripotent stem cells such as human embryonic stem cells first to neuroectoderm, then further to glial progenitor cells, and further to oligodendrocyte progenitor cells (OPCs), and compositions obtained thereby. The methods of the present disclosure reproducibly produce neuroectoderm progenitor cells by day 7 of the differentiation process, glial progenitor cells by day 21 of the differentiation process and OPCs by day 42 of the differentiation process. | 2022-08-25 |
20220267724 | GENERATION OF NEURAL STEM CELLS FROM HUMAN TROPHOBLAST STEM CELLS - Provided herein are isolated neural stem cells and methods of making neural stem cells from human trophoblast stem cells. The isolated neural stem cells can be immune privileged and express one or more protein(s). Also provided are methods for treatment of neurodegenerative diseases using suitable preparations comprising the isolated neural stem cells. | 2022-08-25 |
20220267725 | STEM CELL LINE FOR TREATMENT OF VARIOUS MEDICAL CONDITIONS - An isolated biological stem cell or a set of biological stem cells that include human mesenchymal stem cell line 120816CT, deposited under ATCC Accession number PTA-124321, and differentiated into at least one type of cell selected from the group: neural stem cells, nephron progenitor cells, cardiomyocytes, neurons, glial cells, and vascular endothelial cells. The neurons comprise cholinergic neurons or dopaminergic neurons. A method of treating at least one human physical condition is also disclosed. The method includes injecting a patient with stem cell line 120816 CT to treat osteoarthritis, tendonitis, herniated disc, ligament damage, acute and chronic kidney disease and injury, Parkinson's disease, traumatic brain injury, Alzheimer's disease, amyotrophic lateral sclerosis, spinal cord injury, other skeletal muscular disorders, Lupus erythematosus, multiple sclerosis, cardiovascular disease, Graft-versus host disease, liver dysfunction or diseases, Type 1 and Type 2 diabetes, myocardial ischemia, heart failure, coronary artery disease, and other disorders characterized by inflammation. | 2022-08-25 |
20220267726 | ORDERED PROCESSING OF BLOOD PRODUCTS TO PRODUCE THERAPEUTICALLY ACTIVE CELLS - Provided are methods for processing a blood related sample comprising: (a) providing a blood related sample comprising one or more target cells, platelet cells, red blood cells; and (b) reducing a number of the platelet cells in the blood related sample while maintaining a ratio of the red blood cells to the one or more target cells above a critical threshold to produce a reduced platelet blood related sample comprising the one or more target cells. Also described herein are cell compositions produced by applying the methods described herein. | 2022-08-25 |
20220267727 | GENE-REGULATING COMPOSITIONS AND METHODS FOR IMPROVED IMMUNOTHERAPY - The present disclosure provides methods and compositions related to the modification of immune effector cells to increase therapeutic efficacy. In some embodiments, immune effector cells modified to reduce expression of one or more endogenous target genes, or to reduce one or more functions of an endogenous protein to enhance effector functions of the immune cells are provided. In some embodiments, immune effector cells further modified by introduction of transgenes conferring antigen specificity, such as exogenous T cell receptors (TCRs) or chimeric antigen receptors (CARs) are provided. Methods of treating a cell proliferative disorder, such as a cancer, using the modified immune effector cells described herein are also provided. | 2022-08-25 |
20220267728 | ALLOGENIC CAR-T CELL THERAPY - The invention relates to the use of dextran sulfate, or a pharmaceutically acceptable salt thereof, in modulating leukocyte activation in allogenic CAR-T cell therapy. Dextran sulfate can be used together with allogenic CAR-T cells to achieve an activation pattern similar to what is obtained in autologous CAR-T cells therapy. Hence, dextran sulfate, or the pharmaceutically acceptable salt thereof, is capable of suppressing unspecific leukocyte activation in connection with allogenic CAR-T cell therapy. | 2022-08-25 |
20220267729 | METHODS OF T CELL PRODUCTION - This invention relates to the production of a population of TCR αβ+ T cells by a method comprising (i) differentiating a population of haematopoietic progenitor cells (HPCs) into progenitor T cells and (ii) maturing the progenitor T cells to produce a population of TCR αβ+ T cells. One or both of steps (i) and (ii) are performed in the presence of Inducible Co-stimulator ligand (ICOS-L). The presence of ICOS-L in steps (i) and/or (ii) may increase expression of αβ T cell receptors and/or increase the proportion of HPCs or progenitor T cells that mature into TCR αβ+ cells. This may be useful for example in the production of T cells for immunotherapy. | 2022-08-25 |
20220267730 | EX VIVO GENERATION OF IMMUNOCYTES RECOGNIZING BROTHER OF THE REGULATOR OF IMPRINTED SITES (BORIS) EXPRESSING CANCER STEM CELLS - Disclosed are means, methods and compositions of matter useful for induction of immunity towards cancer stem cells by providing a dendritic cell, wherein said dendritic cells express BORIS and/or peptides derived from BORIS, wherein said dendritic cell is cultured in the presence of one or more immunocytes. In one embodiment said dendritic cells are derived from umbilical cord blood sources and allogeneic to T cells, which are expanded ex vivo and used for the purposes of immunotherapy. | 2022-08-25 |
20220267731 | ANTI-ROBO1 CAR-T CELL, AND PREPARATION AND APPLICATION THEREOF - Provided is a method for modifying a chimeric antigen receptor-modified T cell (CAR-T cell). The method comprises expressing an ScFv-CD8-4-1 BB-CD3ζ molecule in a T cell. The CAR-T cell prepared using the method can specifically recognize and bind to a tumor cell with elevated expression of a ROBO1 protein, and can be used to prevent and treat a corresponding tumor-related disease | 2022-08-25 |
20220267732 | DUX4 EXPRESSING CELLS AND USES THEREOF - Disclosed herein are cells expressing DUX4 including stem cells, differentiated cells thereof, primary T cells, and chimeric antigen receptor T cells, as well as related methods of their use and generation. In some embodiments, the cells disclosed herein do not express one or more MHCI and/or MHC II human leukocyte antigens. In some embodiments, such cells possess immune evasion properties. | 2022-08-25 |
20220267733 | METHODS OF PRODUCING HAEMOGENIC PROGENITOR CELLS FROM PLURIPOTENT STEM CELLS - This invention relates to the production of a population of haemogenic progenitor cells by (i) differentiating a population of induced pluri potent stem cells (IPSCs) into mesoderm cells and; (II) differentiating the mesoderm cells to produce a population of haemogenic progenitor cells. Steps (i) and (ii) are performed without purification or isolation of cells in the population. In addition, the haemogenic progenitor cells may be produced without the use of serum or stromal co-culture. Methods of the invention may be useful for example, in the production of clinical grade blood cells, such as T cells, for use in immunotherapy. | 2022-08-25 |
20220267734 | HETEROGENEOUS STEM CELL POPULATION, PREPARATION METHOD THEREFOR AND USE THEREOF - Disclosed are a heterogeneous stem cell population, a preparation method therefor, and the use thereof. Specifically, disclosed is a heterogeneous stem cell population, characterized in that stem cells in the heterogeneous stem cell population express stemness genes MYC, KLF4, GMNN, SOX2 and NANOG, and in the heterogeneous stem cell population, the ratio of stem cells expressing CD146 is 1%-50%. | 2022-08-25 |
20220267735 | METHOD FOR CULTURING PRIMARY CELLS FROM SOLID TUMOR OF LUNG CANCER AND PRIMARY TUMOR CELLS FROM PLEURAL EFFUSION OF LUNG CANCER AND AUXILIARY REAGENTS - A method for culturing primary cells from solid tumor tissues of lung cancer and primary tumor cells from pleural effusion of lung cancer, and the auxiliary reagents. A method for culturing primary cells from solid tumor tissues of lung cancer and primary tumor cells from pleural effusion of lung cancer and the auxiliary reagents. The core of the technology is as follows: (1) solid tumor of lung cancer are treated by using a mild cell dissociating reagent, and lung cancer cells in pleural effusion are dissociated by a mild method, ensuring the vitality of cancer cells to the greatest extent; (2) a special serum-free medium is prepared, and tumor cells derived from solid tumor tissues of lung cancer are cultured in vitro by using a suspension culture system, ensuring the normal amplification of the cancer cells while eliminating the interference of normal cells to the greatest extent. | 2022-08-25 |
20220267736 | PLURIPOTENT STEM CELL AGGREGATION SUPPRESSOR - The present application provides: a suppressor of pluripotent stem cell aggregation for use in suspension culture of pluripotent stem cells, comprising a cell cycle arresting agent; a method for producing a pluripotent stem cell aggregate(s), comprising a step of subjecting pluripotent stem cells to suspension culture in a culture medium comprising the suppressor; a pluripotent stem cell aggregate obtained by the method; and a composition for culture of pluripotent stem cells comprising a cell aggregate(s) of pluripotent stem cells, a culture medium, and a cell cycle arresting agent. According to the method, it is possible, in suspension culture of pluripotent stem cells, to produce a cell aggregate(s) with high cell viability and appropriate size in a high yield while maintaining the undifferentiated state of the cells and suppressing the aggregation. | 2022-08-25 |
20220267737 | CELL-TYPE SELECTIVE IMMUNOPROTECTION OF CELLS - The present disclosure is directed to preparation of one or more cells, wherein cells of the preparation are modified to conditionally express (i) increased levels of one or more immune checkpoint proteins as compared to corresponding wild-type cells, (ii) reduced levels of one or more HLA-I proteins as compared to corresponding wild-type cells, or a combination of (i) and (ii). The present disclosure is further directed to methods and constructs for producing the cell preparations as well as methods of administering the cell preparation to a subject in need thereof. | 2022-08-25 |
20220267738 | Method For Purifying An Enveloped Virus - The present invention relates to a method for purifying an enveloped virus. The present invention further relates to an enveloped virus or a plurality of enveloped viruses obtainable by said method. | 2022-08-25 |
20220267739 | AAV-MEDIATED DELIVERY OF THERAPEUTIC ANTIBODIES TO THE INNER EAR - Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide. | 2022-08-25 |
20220267740 | PARAMYXOVIRUS VIRUS-LIKE PARTICLES AS PROTEIN DELIVERY VEHICLES - Provided are modified virus-like particles (VLPs) of paramyxoviruses, compositions containing them, methods of using the VLPs for delivery of any particular protein of interest to any of a variety of cells, kits that contain expression vectors for making, using and detecting VLPs, and methods for screening for anti-viral compounds using the VLPs. The modified VLPs contain a contiguous recombinant polypeptide that contains i) all or a segment of a C-terminal domain of a paramyxovirus nucleocapsid protein and ii) a polypeptide sequence of a distinct protein. Non-covalent complexes of paramyxovirus M protein and fusion proteins that contain a C-terminal domain of a paramyxovirus nucleocapsid protein and a polypeptide sequence of a distinct protein are provided, as are non-covalent complexes of cells, and cell receptors, with modified VLPs. | 2022-08-25 |
20220267741 | ENZYME CAPABLE OF DEHYDROXYLATING HYDROXYL GROUP IN UROLITHIN COMPOUND - An object of the present disclosure is, at least, to provide an enzyme that dehydroxylates hydroxyl groups at predetermined positions of urolithins having hydroxyl groups at the predetermined positions, and the object can be solved by an enzyme having the following properties (1) and (2): (1) dehydroxylating a hydroxyl group at the 4-position of urolithins; and (2) in the presence of methyl viologen (MV), being activated by one or more components selected from the group consisting of: reduced nicotinamide adenine dinucleotide (NADH); reduced nicotinamide adenine dinucleotide phosphate (NADPH); flavin adenine dinucleotide (FAD); and flavin adenine mononucleotide (FMN). | 2022-08-25 |
20220267742 | NADPH-REGENERATION SYSTEM BASED ON MONOMERIC ISOCITRATE DEHYDROGENASE AND USE THEREOF - The present invention relates to an NADPH-regeneration system based on monomeric isocitrate dehydrogenase (IDH) and a use thereof. Specifically, the present invention relates to a recombinant vector including a polynucleotide encoding an isocitrate dehydrogenase recombinant protein derived from | 2022-08-25 |
20220267743 | HSD17B13 Variants And Uses Thereof - Provided are compositions related to HSD17B13 variants, including nucleic acid molecules and polypeptides related to variants of HSD17B13, and cells comprising those nucleic acid molecules and polypeptides. Also provided are methods related to HSD17B13 variants. Such methods include methods for detecting the presence of the HSD17B13 rs72613567 variant in a biological sample comprising genomic DNA, for detecting the presence or levels of any one of variant HSD17B13 Transcripts C, D, E, F, G, and H, and particularly D, in a biological sample comprising mRNA or cDNA, or for detecting the presence or levels of any one of variant HSD17B13 protein Isoforms C, D, E, F, G, or H, and particularly D, in a biological sample comprising protein. Also provided are methods for determining a subject's susceptibility to developing a liver disease or of diagnosing a subject with liver disease. | 2022-08-25 |
20220267744 | KETOREDUCTASE POLYPEPTIDES FOR THE PREPARATION OF PHENYLEPHRINE - The disclosure relates to engineered ketoreductase polypeptides and processes of using the polypeptides for production of phenylephrine. | 2022-08-25 |
20220267745 | ENGINEERED ALPHA-1,3 BRANCHING ENZYMES - Disclosed herein are glucosyltransferases with modified amino acid sequences. Such engineered enzymes have modified alpha-1,3-branching activity. Further disclosed are reactions and methods in which engineered glucosyltransferases can be used to add one or more alpha-1,3 branches to a suitable acceptor such as glucan. | 2022-08-25 |
20220267746 | HEPARIN SKELETON SYNTHASE AND ITS MUTANTS AND APPLICATION - A heparin skeleton synthase originates from | 2022-08-25 |
20220267747 | Cascade/dCas3 Complementation Assays for In Vivo Detection of Nucleic Acid-Guided Nuclease Edited Cells - The present disclosure relates to methods and compositions that allow one to identify in vivo edited cells when employing nucleic-acid guided editing. Additionally provided are automated multi-module instruments for performing editing and selection methods and using the compositions. | 2022-08-25 |
20220267748 | AMYLASE VARIANTS - Genetically engineered enzymes having amylase enzyme activity, compositions comprising the enzymes, and methods of making and using the enzymes. The genetically engineered amylase enzymes are useful in many different applications such as laundry detergents, dish washing detergents, and cleaning products for homes, industry, vehicle care, baking, animal feed, pulp and paper processing, starch processing, brewing, and ethanol production. | 2022-08-25 |
20220267749 | ENGINEERED HEME-BINDING COMPOSITIONS AND USES THEREOF - Described herein are heme-binding compositions and methods relating to their use, for example methods of treatment of sepsis and rhabdomyolysis. | 2022-08-25 |
20220267750 | Soluble Intein Fusion Proteins And Methods For Purifying Biomolecules - The present invention relates to fusion proteins comprising an N-intein polypeptide and an N-intein solubilization partner, and affinity chromatography matrices comprising such fusion proteins, as well as methods of using same. | 2022-08-25 |
20220267751 | METHODS FOR MAKING RECOMBINANT PROTEIN - The present invention relates to methods of producing recombinant plasminogen in a mammalian expression system. A method for producing plasminogen, the method comprising (i) providing a host cell comprising a first recombinant polynucleotide encoding plasminogen and a second recombinant polynucleotide encoding a plasminogen activation inhibitor; (ii) culturing said host cell in a suitable culture medium under conditions to effect expression of plasminogen from the first polynucleotide and plasminogen activation inhibitor from the second polynucleotide. | 2022-08-25 |
20220267752 | CELL-TARGETED CYTOTOXIC CONSTRUCTS - Cell-targeted cytotoxic agents, including sortase serine protease constructs, are provided. Such compounds can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant sortase serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. | 2022-08-25 |
20220267753 | RATIONAL THERAPEUTIC TARGETING OF ONCOGENIC IMMUNE SIGNALING STATES IN MYELOID MALIGNANCIES VIA THE UBIQUITIN CONJUGATING ENZYME UBE2N - Methods and compositions disclosed herein generally relate to compositions and methods for suppressing hematopoietic stem and progenitor cells (HSPCs) and the treatment of diseases or disorders involving UBE2N, such as cancers, including disorders such as myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) and chronic inflammatory disorders. Particular aspects relate to treating, e.g. acute myelomonocytic leukemia (AML-M4) and acute monocytic leukemia (AML-M5). Particular aspects of the invention relate to determining an individual in need of treatment who can be treated with a UBE2N inhibitor, such as an individual having AML-M4 and/or AML-M5. The invention further relates to using a UBE2N inhibitor to treat a disease or disorder characterized by malignant hematopoietic cells, as well as other cancers, and chronic inflammatory disorders, and as immune checkpoint regulators. | 2022-08-25 |
20220267754 | VECTOR-BASED MUTAGENESIS SYSTEM - Strategies, reagents, methods, and systems for modulating the mutation rate in cells are provided herein. The strategies, reagents, methods, and systems are broadly applicable for the modulation of mutation rates in cells where high mutation rates and/or control over a broad range of mutation rates is desired, for example, in the context of diversifying a nucleic acid sequence or a plurality of such sequences within a population of cells, for the generation of diversified nucleic acid libraries, and for directed evolution of nucleic acids and encoded products. | 2022-08-25 |
20220267755 | MODIFIED ORGANISMS FOR IMPROVED FLAVOR AND AROMA - The present disclosure provides for genetically modified organisms that provide numerous health benefits but also have an improved flavor profile and a more palatable aroma for the consumer of the organism. | 2022-08-25 |
20220267756 | COMPOSITIONS AND METHODS FOR MODULATING GENOMIC COMPLEX INTEGRITY INDEX - The present disclosure relates generally to modulation of genomic complexes via modulation (e.g., disruption) based on certain integrity index scores. | 2022-08-25 |
20220267757 | INTEGRATED SYRINGE - Various embodiments relate to a syringe for separating nucleic acids from a blood sample and systems that include the syringe and a portable PGR device. The syringe may include a shell defining a central aperture extending through a longitudinal axis of the syringe, a plunger disposed within the central aperture of the shell, and a core rotatably disposed within the central aperture. The syringe may further include a needle fluidically connectable to the inlet of the shell. Various embodiments relate to a method for separating nucleic acids from a blood sample, the method comprising drawing the blood sample from a patient using the syringe according to any of the embodiments described herein. | 2022-08-25 |
20220267758 | GOLD NANOPARTICLE-SELEX BASED SCREENING METHOD FOR TARGET-SPECIFIC APTAMERS - Systematic Evolution of Ligand Exponential Enrichment (SELEX) is involved to screen DNA/RNA aptamers that recognize a target molecule (including biomolecules such as nucleic acids, lipids, sugars, proteins, and peptides, hormones, low molecular weight chemical substances, toxic substances, ions, etc.). In general, in order to perform SELEX, a process of fixing a target molecule on a substrate or bead surface is required. In addition, since positive/negative monitoring is not possible in each round of a SELEX process to observe whether an aptamer library is actually well combined with a target substance, whether the SELEX process is proceeded correctly is checked by analyzing aptamers screened through several rounds. In order to remarkably solve these conventional problems and to construct a simpler and easier SELEX technique, the present disclosure provides a new SELEX technique using gold nanoparticles. | 2022-08-25 |
20220267759 | METHODS AND COMPOSITIONS FOR SCALABLE POOLED RNA SCREENS WITH SINGLE CELL CHROMATIN ACCESSIBILITY PROFILING - An in vitro method is provided for analyzing chromatin accessibility and screening RNA of each single cell in a heterologous population (e.g., a library of cells). The method comprises incubating cell nuclei obtained from lysed cells with a transposome complex in a tagmentation buffer, performing reverse transcription wherein each of the RNAs is reverse transcribed to a DNA barcoded with the first barcode; sequencing DNA, which is extracted from digested cell nuclei; and analyzing chromatin accessibility and RNA of the cells. In a further embodiment, the method described comprises performing combinatorial cellular indexing and/or a perturbation step. Additionally, provided are a transposase TnY, buffer(s), and kit(s) for use in the described method. | 2022-08-25 |
20220267760 | LIBRARY PREPARATION METHOD AND APPLICATION - A method for preparing an amplicon library for detecting the variation in a region to be tested of a target gene of a sample, including the following steps: 1) designing and synthesizing a forward outer primer F1, a forward inner primer F2, and a reverse primer R according to the target region; 2) carrying out a one-step PCR amplification on the sample to be tested using the forward outer primer F1, the forward inner primer F2, and the reverse inner primer R to obtain an amplified product, i.e., the amplicon library of the target region. This one-step library preparation technology can be applied to all second-generation platforms including IonTorrent, illumina and BGI/MGI platforms. Based on the library preparation method, the present invention has developed detection products for SNP, Ins/Del, CNV and methylation of DNA, as well as detection products for s gene fusion and expression of RNA samples. | 2022-08-25 |
20220267761 | REVERSE TRANSCRIPTION DURING TEMPLATE EMULSIFICATION - Methods to emulsify cells and/or mRNA with reverse transcriptase at a temperature such that the reverse transcriptase begins making cDNA during the emulsification | 2022-08-25 |
20220267762 | CLOSED LOOP CONTINUOUS APTAMER DEVELOPMENT SYSTEM - The present disclosure relates to a closed loop aptamer development system that identifies one or more aptamers observed experimentally and implements machine-learning models to identify other aptamers not observed experimentally. Particularly, aspects of the present disclosure are directed to receiving a query concerning one or more targets, acquiring a library of aptamers that potential satisfy the query, identifying a first set of aptamers from the library of aptamers that substantially or completely satisfy the query, obtaining sequence data for the first set of aptamers, generating, by a prediction model, a third set of aptamers derived from the sequence data for the first set of aptamers, validating the third set of aptamers that substantially or completely satisfy the query, and upon validating the third set of aptamers and in response to the query, providing the third set of aptamers as a result to the query. | 2022-08-25 |
20220267763 | HIGH EFFICIENCY CONSTRUCTION OF DNA LIBRARIES - The invention provides a method for efficient DNA library construction and targeted genetic analyses of the libraries. | 2022-08-25 |
20220267764 | METHODS AND SYSTEMS FOR RNA-SEQ PROFILING - Disclosed herein are methods for counting nucleic acid molecules (e.g., RNA molecules) of a sample by randomly truncating the nucleic acid molecules at a truncation base position within the nucleic acid molecules to produce truncated nucleic acid molecules, amplifying and sequencing the truncated nucleic acid molecules to produce sequencing reads, aligning the sequencing reads to a reference sequence to produce aligned sequencing reads, and identifying a number of nucleic acid molecules using truncation locations of aligned sequencing reads. Also disclosed herein are methods for constructing sequencing libraries that preserve truncation positions of the nucleic acid molecules. Also disclosed herein are methods for depleting or enriching a sample for one or more target sequences, using sets of blocking oligonucleotides corresponding to the one or more target sequences. | 2022-08-25 |
20220267765 | TREATMENT OF GENETIC DISORDERS ASSOCIATED WITH DNA REPEAT INSTABILITY - The current invention provides for methods and medicaments that apply oligonucleotide molecules complementary only to a repetitive sequence in a human gene transcript, for the manufacture of a medicament for the diagnosis, treatment or prevention of a cis-element repeat instability associated genetic disorders in humans. The invention hence provides a method of treatment for cis-element repeat instability associated genetic disorders. The invention also pertains to modified oligonucleotides which can be applied in method of the invention to prevent the accumulation and/or translation of repeat expanded transcripts in cells. | 2022-08-25 |
20220267766 | RNA INTERFERENCE-INDUCING NUCLEIC ACID INHIBITING NONCANONICAL TARGETS OF MICRO RNA, AND USE FOR SAME - The present invention relates to RNA interference-inducing nucleic acid that inhibits noncanonical target genes of micro RNA, in which part of the sequence of a specific micro RNA has been modified, and by using the RNA interference-inducing nucleic acid of the present invention, the biological function micro RNA exhibits by inhibiting noncanonical target genes is effectively increased or there is the benefit of selectively exhibiting only one of the biological functions of conventional micro RNA, i.e., the function of inhibiting noncanonical target genes, and the interference-inducing nucleic acid of the present invention enables cell cycling, differentiation, dedifferentiation, formation, movement, splitting, proliferation or death adjustment, and it is expected that the invention can be used in various fields such as drugs and cosmetics. | 2022-08-25 |
20220267767 | METHODS FOR TREATING OR PREVENTING CONTACT-ACTIVATION PATHWAY-ASSOCIATED DISEASES USING iRNA COMPOSITIONS TARGETING FACTOR XII (HAGEMAN FACTOR) (F12) - The present invention relates to methods of use of RNAi agents, e.g., double stranded RNAi agents, targeting a Factor XII (Hageman Factor (F12) gene, for treating subjects having a contact activation pathway-associated disease, such as a thrombophilia or hereditary angioedema (HAE), methods for preventing at least one symptom in a subject having a contact activation pathway-associated disease, such as a thrombus formation or an angioedema attack, and RNAi agents targeting an F12 gene, for use in the methods of the invention. | 2022-08-25 |
20220267768 | RECOMBINANT VIRUS PRODUCTS AND METHODS FOR INDUCING DUX4 EXON SKIPPING - The present invention relates to methods for shifting the splicing profile of the DUX4 gene, a double homeobox gene on human chromosome 4q35. Recombinant adeno-associated viruses of the invention deliver DNAs encoding U7-based small nucle-ar RNAs to induce DUX4 exon- skipping and the expression of shortened forms of DUX4. The methods have application in the treatment of muscular dystrophies such as facioscapulohumeral muscular dystrophy. | 2022-08-25 |
20220267769 | MEDICAL USES, METHODS AND USES - Described are agents which inhibit microRNA-144 (miR-144) for use in treating or preventing a liver disease and/or liver condition in which oxidative stress is a contributory factor in a subject, methods for identifying a subject who has, or who is at risk of developing, said liver disease and/or liver condition, methods of predicting the response of a subject with said liver disease and/or liver condition to an agent which inhibits miR-144, methods of diagnosing said liver disease and/or liver condition, pharmaceutical compositions and kits. | 2022-08-25 |
20220267770 | COMPOSITIONS AND METHODS OF USING C/EBP ALPHA SARNA - The disclosure relates to a pharmaceutical composition comprising an saRNA targeting C/EBPα and at least one additional active agent. Methods of using the pharmaceutical composition are also provided. | 2022-08-25 |
20220267771 | PRODUCTION METHOD FOR BIFURCATED LIPID-LINKED OLIGONUCLEOTIDE, AND INTERMEDIATE - Provided are production methods capable of controlling quality of a bifurcated lipid-linked oligonucleotide, and intermediates which is useful for the production method, has good stability, and is easy to manage and analyze. Specifically, it is a method for producing a bifurcated lipid-linked oligonucleotide including a step of reacting a compound of formula (II): | 2022-08-25 |
20220267772 | IMMUNOSTIMULATORY SEQUENCE OLIGONUCLEOTIDES AND METHODS OF USING THE SAME - The invention provides immunomodulatory polynucleotides and methods for immunomodulation of individuals using the immunomodulatory polynucleotides. | 2022-08-25 |
20220267773 | Targeted RNA cleavage with CRISPR-Cas - The present invention provides proteins, nucleic acids, systems and methods for modulating RNA. | 2022-08-25 |
20220267774 | METHODS AND COMPOSITIONS TO DIRECT BREAKDOWN OF INSULIN MRNA IN BENIGN FASHION - Methods and compositions discussed herein allow for preventing or treating type 1 diabetes (T1D) including directing the breakdown of insulin mRNA. | 2022-08-25 |
20220267775 | CANCER TREATMENT USING TARGETED siRNA PHARMACEUTICAL FORMULATIONS TO DOWNREGULATE EXPRESSION OF PRDM14 PROTEIN - Pharmaceutical formulations for the treatment of cancer comprising novel siRNAs that downregulate expression of the PRDM oncoprotein gene and inhibit tumor growth. siRNAs designed and selected to destroy PRDM14 mRNA are described. The siRNAs are delivered via one or more targeted drug delivery systems equipped with a tumor-specific targeting ligand that confers specific binding of the nanoparticle with siRNA payload to receptors on the surface of tumor cells. | 2022-08-25 |
20220267776 | METHODS FOR TREATING RAN PROTEIN-ASSOCIATED NEUROLOGICAL DISEASES - Aspects of the disclosure relate to compositions and methods for the diagnosis and/or treatment of certain neurodegenerative diseases, for example those diseases associated with repeat-associated non-ATG (RAN) translation proteins, such as Alzheimer's disease (AD). In some embodiments, the disclosure relates to identifying a subject having a RAN protein-associated disease by detecting expression or activity of repeat-associated non-ATG (RAN) translation proteins (e.g., RAN proteins). In some embodiments, the disclosure relates to methods of treating a RAN protein-associated disease by administering to a subject in need thereof an agent that reduces expression or activity of RAN proteins. | 2022-08-25 |
20220267777 | DIFFERENTIAL KNOCKOUT OF A HETEROZYGOUS ALLELE OF RPE65 - RNA molecules comprising a guide sequence portion having 17-25 contiguous nucleotides in the sequence set forth in any one of SEQ ID NOs: 1-49516 and compositions, methods, and uses thereof. | 2022-08-25 |
20220267778 | NUCLEIC ACID DRUG TARGETING MURF1 - It was found that nucleic acids for the specific targeting sequences or nucleic acids having the specific sequences have superior suppression activities of MURF1 expression. Pharmaceutical compositions including the nucleic acids as active ingredient are useful for treating or preventing disease accompanied by one or more symptoms selected from the group consisting of decrease in muscle mass, decrease in muscle strength and muscle dysfunction. | 2022-08-25 |
20220267779 | SIRNA STRUCTURES FOR HIGH ACTIVITY AND REDUCED OFF TARGET - This invention provides compounds, compositions and methods for modulating the expression of target genes using RNA interference. RNAi structures and molecules of this invention can be used for modulating or silencing the expression of genes, with high levels of RNAi activity and reduced off target actions. Advantageous structures include siRNAs targeted to any gene having one or more 2′-deoxy nucleotides located in the seed region. The RNA interference molecules can be used in methods for preventing or treating diseases. | 2022-08-25 |
20220267780 | CONJUGATES OF BILE ACIDS AND THEIR DERIVATIVES FOR ACTIVE MOLECULES DELIVERY - A conjugate of oligonucleotides and bile acid derivatives having the structure (I), (II) or (III), pharmaceutical compositions thereof, and uses thereof are described. | 2022-08-25 |
20220267781 | IMMUNE CELLS WITH ENHANCED CYTOTOXICITY AND METHODS OF USE THEREOF - This disclosure provides methods for enhancing antitumor cytotoxicity of immune cells by introducing to the immune cells a genetic modification that comprises overexpression of RHEB or a functional fragment thereof, overexpression of LAMP 1-RHEB or a functional fragment thereof, overexpression of CA9 or a functional fragment thereof, overexpression of NHE1 or a functional fragment thereof, or combination thereof. | 2022-08-25 |
20220267782 | NUCLEIC ACID CONSTRUCT COMPRISING 5' UTR STEM-LOOP FOR IN VITRO AND IN VIVO GENE EXPRESSION - The present invention relates to the field of recombinant production of biological molecules in host cells. The invention provides nucleic acid constructs that allow to modify expression of a desired gene using both in vitro and in vivo gene expression systems with optimized stem-loop structures in the 5′ UTR of said genes. The constructs can advantageously be used to produce a variety of biological molecules recombinantly in industrial scales, e.g. human milk oligosaccharides (HMOs) | 2022-08-25 |
20220267783 | FILAMENTOUS FUNGAL EXPRESSION SYSTEM - The present invention provides recombinant filamentous fungal host cells producing one or more secreted polypeptide of interest, said cells comprising in their genome at least one nucleic acid construct comprising a first polynucleotide encoding a signal peptide operably linked in translational fusion to a second polynucleotide encoding the polypeptide of interest, wherein the first polynucleotide is heterologous to the second polynucleotide, wherein the first polynucleotide is a polynucleotide having at least 70% sequence identity with SEQ ID NO:1 or a polynucleotide encoding a signal peptide having at least 70% sequence identity with SEQ ID NO:2, as well as methods of producing one or more secreted polypeptide of interest. | 2022-08-25 |
20220267784 | PROTEIN PRODUCTION IN PLANT CELLS - Improved methods of producing nucleic acid molecules, proteins and peptides in host cells and genetically engineered plants, vectors and constructs therefor. | 2022-08-25 |
20220267785 | OPTIMIZED TISSUE-PREFERRED PROMOTER AND USES THEREOF - The present disclosure provides the identification of promoters that are preferentially active in tobacco axillary buds. Also provided are tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing tobacco plants comprising reduced or no sucker growth. | 2022-08-25 |
20220267786 | GENETICALLY MODIFIED REDUCED-BROWNING FRUIT-PRODUCING PLANT AND PRODUCED FRUIT THEREOF, AND METHOD OF OBTAINING SUCH - A genetically modified fruit-producing plant, said plant having sufficiently reduced total Polyphenol Oxidase (PPO) activity relative to a wild type of said plant to reduce browning in the fruit of said plant relative to said wild type, wherein the reduced total PPO activity results from a reduction in activity of at least two PPO isoenzymes in said plant relative to said wild type, or a cell, seed, seedling, part, tissue, cell, fruit or progeny of said plant. | 2022-08-25 |
20220267787 | GENETIC LOCUS IMPARTING A LOW ANATABINE TRAIT IN TOBACCO AND METHODS OF USING - Provided herein are genetic markers and a coding sequence associated with a low- or ultra-low anatabine trait in tobacco. | 2022-08-25 |
20220267788 | CREATION OF HERBICIDE RESISTANT GENE AND USE THEREOF - The present invention belongs to the field of plant genetic engineering. Specifically, the invention relates to a method for creating novel herbicide resistant plants by base editing techniques and a method for screening endogenous gene mutation sites capable of conferring herbicide resistance in plants. The invention also relates to the use of the identified endogenous gene mutantation sites in crop breeding. | 2022-08-25 |
20220267789 | NOVEL RESISTANCE GENES ASSOCIATED WITH DISEASE RESISTANCE IN SOYBEANS - The present invention relates to methods and compositions for identifying, selecting and/or producing a Disease resistant soybean plant or germplasm using genes derived from | 2022-08-25 |
20220267790 | IDENTIFICATION OF RESISTANCE GENES FROM WILD RELATIVES OF BANANA AND THEIR USES IN CONTROLLING PANAMA DISEASE - The present disclosure provides compositions and methods for providing broad-based resistance to fungal pathogens, such as a | 2022-08-25 |
20220267791 | BEGOMOVIRUS RESISTANCE RELATED GENES - The present invention relates to a modified PriL gene, which encodes a modified protein which may comprise one or more modifications in the wild type protein sequence of SEQ ID NO: 1 or SEQ ID NO: 3 or in a protein sequence having at least 60% sequence identity to SEQ ID NO: 1 or SEQ ID NO: 3. Alternatively, the wild type of the modified PriL gene encodes a protein according to SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 7, SEQ ID NO: 11, SEQ ID NO: 13, SEQ ID NO: 15, SEQ ID NO: 17, SEQ ID NO: 19, SEQ ID NO: 21, SEQ ID NO: 23, SEQ ID NO: 25, SEQ ID NO: 27, SEQ ID NO: 29, or SEQ ID NO: 31. The modification in the wild type protein sequence is an amino acid substitution. | 2022-08-25 |
20220267792 | COMPOSITIONS AND METHODS TO CONTROL INSECT PESTS - Methods and compositions are provided which employ a silencing element that, when ingested by a plant insect pest, such as Coleopteran, Hemiptera, or Lepidopteran plant pest, including a | 2022-08-25 |
20220267793 | COMPOSITIONS AND METHODS FOR CONTROL OF INSECT INFESTATIONS IN PLANTS - The present invention is directed to controlling pest infestation by inhibiting one or more biological functions in an invertebrate pest. The invention discloses methods and compositions for use in controlling pest infestation by feeding one or more different recombinant double stranded RNA molecules to the pest in order to achieve a reduction in pest infestation through suppression of gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and to particular combinations of transgenic pesticidal agents for use in protecting plants from pest infestation. | 2022-08-25 |