34th week of 2010 patent applcation highlights part 47 |
Patent application number | Title | Published |
20100216817 | Antitumoral Tetrahydro-Pyrimidines - Antitumoral compounds of the formula (I) wherein X is O, S, or NRa, obtained from a maze coral of the family Meandrinidae, genus | 2010-08-26 |
20100216818 | Inhibitors of Post-Amadori Advanced Glycation End Products - The present invention provides compounds, pharmaceutical compositions, and methods for treating or inhibiting development of AGE- and/or ALE-associated complications in subjects in need thereof. | 2010-08-26 |
20100216819 | Thiazolopyrimidines for Use in Therapy - Use of a compound of formula (I) wherein R is an alicyclic group; an arylethyl group; or phenyl or benzyl substituted by halogen, lower alkyl, alkoxy, OH, NH | 2010-08-26 |
20100216820 | THIENOPYRIMIDIONES FOR TREATMENT OF INFLAMMATORY DISORDERS AND CANCERS - The current invention provides compounds of formula (1): wherein: one of Q | 2010-08-26 |
20100216821 | Benzimidazoles With A Hetero Spiro-Decane Residue As NPY-Y5 Antagonists - The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salts, solvates, stereoisomers thereof, | 2010-08-26 |
20100216822 | Nucleotide Analogue Prodrug and the Preparation Thereof - (R)-9-[2-bis[pivaloyloxymeihoxy]phosphinoylmethoxypropyl]adenine (being abbreviated bis-POMPMPA, TD), the derivative and the use thereof. Also including the synthetic process of TD and the procedure for manufacturing solid TD, as well as the composition containing TD and the procedure for manufacturing the composition. | 2010-08-26 |
20100216823 | Spirocyclic Derivatives - The invention provides compounds of formula (I): | 2010-08-26 |
20100216824 | Anti-cancer cyclopenta [G]quinazonline compounds - Cyclopenta[g]quinazolines of the formula (I):— | 2010-08-26 |
20100216825 | FUNGICIDAL COMPOSITIONS - A composition for control of diseases on useful plants or on propagation material thereof caused by phytopathogens, comprising (A) a compound of formula (I) or a tautomer of such a compound; and component (B) and component (C) are pesticides as described in claim | 2010-08-26 |
20100216826 | Polymorphisms in Voltage-Gated Sodium Channel Alpha 1-Subunit as Markers for Therapy Selection - A method for determining whether a patient in need thereof will respond to chemotherapy by screening a suitable sample isolated from the patient for a pre-selected polymorphism present in the VGSC gene. | 2010-08-26 |
20100216827 | ARYL GPR120 RECEPTOR AGONISTS AND USES THEREOF - Aryl GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control. | 2010-08-26 |
20100216828 | METHODS AND COMPOSITIONS FOR TREATING CANCERS - This invention provides a combination of antagonists of the hedgehog signaling pathway with a BCR-ABL inhibitor. The combination of the present invention may be used for treating cancers known to be associated with protein tyrosine kinases such as, for example, Src, BCR-ABL and c-kit. | 2010-08-26 |
20100216830 | Oral Composition Comprising A Cooling Agent - The present invention relates to a formulation comprising an endothermic cooling agent selected from the group consisting of xylitol, sorbitol, mannitol and erythritol having a heat of enthalpy between −10 cal/g and −100 cal/g, and one or more active agents wherein the endothermic agent is present in the formulation at an amount less than 10% w/w. | 2010-08-26 |
20100216831 | DESLORATADINE CRYSTALLINE FORMS MIXTURES HAVING A LOW LEVEL OF RESIDUAL SOLVENTS - Provided are desloratadine mixtures, comprising a low level of residual solvents and processes for the preparation thereof. | 2010-08-26 |
20100216832 | Method for Assaying FTO (2-Oxoglutarate Dependent Oxygenase) Activity - The present invention provides a method for assaying oxygenase activity, the method comprising monitoring oxygenase activity of FTO. | 2010-08-26 |
20100216833 | TETRAHYDROCARBAZOLES AND DERIVATIVES - The present invention relates to compounds of the formula (I) | 2010-08-26 |
20100216834 | HIV INTEGRASE INHIBITORS - Stereoisomers of compounds of Formula I are disclosed: wherein V | 2010-08-26 |
20100216835 | Method For Modulating Microbial Quorum Sensing - The present invention provides compositions and methods for modulating bacterial quorum sensing using antagonist or agonist compounds. Further, the present invention provides methods of treating or preventing microbial damages and diseases, in particular for diseases where there is an advantage in inhibiting quorum sensing regulated phenotypes of pathogens. | 2010-08-26 |
20100216836 | 2,3-DIHYDROBENZO(1,4) DIOXIN-2-YLMETHYL DERIVATIVES AS ALPHA2C ANTAGONISTS FOR USE IN THE TREATMENT OF PERIPHERIC AND CENTRAL NERVOUS SYSTEME DISEASES - Compounds of formula I | 2010-08-26 |
20100216837 | GLYCINE TRANSPORT INHIBITORS - The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof. | 2010-08-26 |
20100216838 | FEXOFENADINE BASE POLYMORPHIC FORMS - The invention relates to novel crystalline forms of fexofenadine base, a process for the preparation thereof and the use thereof in therapy. | 2010-08-26 |
20100216839 | Pim kinase inhibitors and methods of their use - The present invention relates to new compounds of Formulas I and II, their tautomers, stereoisomers and polymorphs, and pharmaceutically acceptable salts, esters, metabolites or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the inhibition of Pim kinase activity and/or the prophylaxis or treatment of cancer. | 2010-08-26 |
20100216840 | BENZIMIDAZOLIDINONE DERIVATIVES AS MUSCARINIC AGENTS - Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M | 2010-08-26 |
20100216841 | 4-Fluoro-Piperidine T-Type Calcium Channel Antagonists - The present invention is directed to 4-fluoro-piperidine compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved. | 2010-08-26 |
20100216843 | NOVEL SALT 628 - 6-Methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-{[5-(methylsulfonyl)pyridin-2-yl]methyl}-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide 4-methylbenzenesulfonate and a novel crystalline form thereof are disclosed together with processes for preparing such salt and form, pharmaceutical compositions comprising such a salt and form, and the methods of treatment using such a salt and form. | 2010-08-26 |
20100216844 | Carboxamide compounds and their use as calpain inhibitors - The present invention relates to novel carboxamide compounds and their use as a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity and to a method for the therapeutic and/or prophylactic treatment by administering an effective amount of at least one of these carboxamide compounds. | 2010-08-26 |
20100216845 | ISOXAZOLES / O-PYRIDINES WITH ETHYL AND ETHENYL LINKER - The present invention is concerned with novel isoxazole-pyridines of formula I | 2010-08-26 |
20100216846 | TRISUBSTITUTED 1,2,4 TRIAZOLES - The present invention relates to substituted 1-(alkyl)-3-aniline-5-aryl triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I). | 2010-08-26 |
20100216847 | NORNICOTINE FOR THE TREATMENT OF PAIN - This invention relates to the use of R(+)-, S(−)- or racemic nornicotine for the treatment of pain. | 2010-08-26 |
20100216848 | LIQUID PHARMACEUTICAL COMPOSITIONS FOR PARENTERAL ADMINISTRATION OF A SUBSTITUTED AMIDE - A liquid pharmaceutical composition comprising N-[1S,2S]-3-[(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[(5-trifluoromethyl)pyridine-2-yl]oxy}propanamide is disclosed, together with processes of preparing the liquid pharmaceutical composition, preparing a vessel containing the liquid pharmaceutical composition, the use of the composition for treating and preventing diabetes or obesity and a method of treating or preventing diabetes or obesity comprising administration to a patient in need thereof of an effective amount of the liquid pharmaceutical composition. | 2010-08-26 |
20100216849 | BIPHENYLCARBOXAMIDES - This invention relates to novel biphenylcarboxamides of the formula (I) | 2010-08-26 |
20100216850 | INSECTICIDAL COMPOUNDS - A compound of formula (I) wherein A | 2010-08-26 |
20100216851 | 1,2,4-OXADIAZOLE BENZOIC ACID COMPOSITIONS AND THEIR USE IN BIOASSAYS - Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith. | 2010-08-26 |
20100216852 | METHODS FOR SCREENING ANTIMICROBIAL AND ANTIVIRAL COMPOUNDS AND USES THEREOF - The invention features compounds that have antibacterial activity, their use for the treatment of bacterial infections, screening methods that use whole animals or plant seedlings to identify compounds that inhibit a pathogen in the animal or plant, and screening methods to identify compounds that increase the lifespan of an organism. | 2010-08-26 |
20100216853 | Methods and Compositions for Modulating P300/CBP Activity - The present invention relates to a method for identifying compounds that modulate the activity of p300/CBP. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified lysine-CoA inhibitor binding site, L1 loop, electronegative pocket, or electronegative groove of the HAT domain of p300/CBP and testing the compound for its ability to modulate the activity of p300/CBP. Compositions and methods for preventing or treating diseases or disorders associated with p300/CBP are also provided as is a method for producing a semi-synthetic HAT domain. | 2010-08-26 |
20100216854 | 1,3 AND 1,3,5 SUBSTITUTED IMIDAZOLES AS ANTIHYPERTENSIVES - The present invention provides novel 1,5 and 1,3,5-substituted imidazole compounds of formulas (I), (IIa), (IIIb) in hydrophilic or lipophilic form, which are useful as angiotensin II AT1 receptor antagonists with sympathetic suppressant properties. In particular, the invention provides pharmaceutical compositions containing the pharmacophoric groups of Losartan and Clonidine as well compounds, processes and intermediates for preparing compounds and their use in methods of treating hypertension and cardiovascular diseases through Renin Angiotensin System (RAS) and Sympathetic System (SS). Alkylated histamine based double action Saltans are lipophilic and can act transdermally. | 2010-08-26 |
20100216855 | IMIDAZAOLONE DERIVATIVES,PREPARATION THEREOF AND BIOLOGICAL USE OF SAME - Imidazolone derivatives, as medicaments, of formula | 2010-08-26 |
20100216856 | PROTECTIVE AGENT FOR RETINAL NERVE OR OPTIC NERVE - The present invention provides a protective agent for retinal nerve or optic nerve which exerts its effect through a different mechanism from that of conventional therapeutic agents and can be taken for long periods. The present invention is the protective agent for retinal nerve or optic nerve which comprises a compound with aldose reductase inhibiting activity such as the compound represented by the following general formula as an active ingredient. A preferable compound thereof is (2S,4S)-6-fluoro-2′,5′-dioxospiro[chroman-4,4′-imidazolidine]-2-carboxamide: | 2010-08-26 |
20100216857 | METHOD OF TREATING MOTOR DISORDERS WITH 4-(1-(2,3-DIMETHYLPHENYL)ETHYL)-1H-IMIDAZOLE-2(3H)-THIONE - Disclosed herein is a method of treating motor disorders comprising administering to a subject in need of such treatment 4-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole-2(3H)-thione. | 2010-08-26 |
20100216858 | BENDAMUSTINE CYCLOPOLYSACCHARIDE COMPOSITIONS - The present invention is directed to pharmaceutical compositions comprising: (a) bendamustine, (b) a charged cyclopolysaccharide, and (c) a stabilizing agent having a charge opposite to that of the cyclopolysaccharide. Such composition provides unexpectedly desirable stability in reactive environments such as plasma, coupled with unexpectedly desirable anticancer activity. Such compositions are suitable for injection or infusion into patients in need for treatment with bendamustine. | 2010-08-26 |
20100216859 | CURCUMIN ANALOG COMPOSITIONS AND RELATED METHODS - Novel curcumin-analog compounds are disclosed that are antioxidants useful in inhibition of pro-inflammation, angiogenic, and vascular permeability factors and elimination of reactive oxygen species. The curcumin compounds specifically inhibit VEGF and are useful in treating various diseases that are mediated through the oxidative stress pathway, including those that are characterized by inflammation, angiogenesis, or vascular leakage. | 2010-08-26 |
20100216860 | NOVEL COMPOUNDS - Indazole compounds, processes for their preparation, intermediates usable in these processes, pharmaceutical compositions containing such compounds and their use in therapy. | 2010-08-26 |
20100216861 | AMINO ARYLSULFONAMIDE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS - The present invention relates to novel amino arylsulfonamide compounds of the formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them: The present invention also relates to a process for the preparation of above said novel compounds, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The compounds of the invention are useful in the treatment of various disorders that are related to 5-HT | 2010-08-26 |
20100216862 | Pyrrole Derivatives As Therapeutic Compounds - Novel pyrrole derivatives are disclosed as Aβ | 2010-08-26 |
20100216863 | Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment - Polymorphisms in the FLAP and LTA4H gene are shown by genetic association analysis to be susceptibility markers for myocardial infarction (MI) and ACS, as well as stroke and PAOD. Pathway targeting for treatment and diagnostic applications in identifying those who are at risk of developing MI, ACS, stroke or PAOD, in particular are described. The invention also provides methods of prophylaxis therapy for MI in human subjects having a race including black African ancestry by administering to the subject a composition comprising a therapeutically effective amount of MI therapeutic agent that inhibits leukotriene synthesis in vivo. The invention also provides for compositions comprising a leukotriene synthesis inhibitor and a statin and methods of using these compositions to reduce C-reactive protein in a human subject at risk of MI, ACS, stroke and/or PAOD. | 2010-08-26 |
20100216864 | RNA Antagonist Compounds for the Modulation of PCSK9 - The present invention provides compounds, compositions and methods for modulating the expression of PCSK9. In particular, this invention relates to oligomeric compounds, such as oligonucleotide compounds, which are hybridisable with target nucleic acids encoding PCSK9, and methods for the preparation of such oligomeric compounds. The oligonucleotide compounds have been shown to modulate the expression of PCSK9, and pharmaceutical preparations thereof and their use as treatment of hypercholesterolemia and related disorders are disclosed. | 2010-08-26 |
20100216865 | MicroRNA COMPOSITIONS IN THE TREATMENT OF VEGF-MEDIATED DISORDERS - The invention provides methods of treating diseases caused by the over-production of a VEGF polypeptide by administering miRNA or miRNA inhibitor compositions to decrease at least one activity of a VEGF polypeptide. | 2010-08-26 |
20100216866 | RNAi Modulation of APOB and Uses Thereof - The invention relates to compositions and methods for modulating the expression of apolipoprotein B, and more particularly to the downregulation of apolipoprotein B by chemically modified oligonucleotides. | 2010-08-26 |
20100216867 | Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers - The present invention is directed to the use of bcl-2 antisense oligomers to treat and prevent bcl-2 related disorders. These disorders include cancers, tumors, carcinomas and cell-proliferative related disorders. In one embodiment of the invention, a bcl-2 antisense oligomer is administered at high doses. The present invention is also directed to a method of preventing or treating a bcl-2 related disorder, in particular cancer, comprising administering a bcl-2 antisense oligomer for short periods of time. The present invention is further drawn to the use of bcl-2 antisense oligomers to increase the sensitivity of a subject to cancer therapeutics. The present invention also relates to pharmaceutical compositions comprising one or more bcl-2 antisense oligomers, which may comprise one or more cancer therapeutic agents. | 2010-08-26 |
20100216868 | AGENTS, COMPOSITIONS AND METHODS FOR TREATING PATHOLOGIES IN WHICH REGULATING AN ACHE-ASSOCIATED BIOLOGICAL PATHWAY IS BENEFICIAL - The present invention provides agents which are capable of regulating the function of a micro-RNA component which can be used to regulate an AChE-associated biological pathway. In addition, the present invention provides methods and pharmaceutical compositions for the treatment of various pathologies related to AChE-associated biological pathways such as apoptosis, aberrant cholinergic signaling, abnormal hematopoietic proliferation and/or differentiation, cellular stress, exposure to inflammatory response-inducing agents, and/or exposure to organophosphates or other AChE inhibitors. | 2010-08-26 |
20100216869 | ARTEMISININ DERIVATIVES FOR THE TREATMENT OF MELANOMA - The invention relates to Artemisinin derivatives of general formula (I) | 2010-08-26 |
20100216870 | Novel Genes Encoding a Nystatin Polyketide Synthase and Their Manipulation and Utility - The invention provides a nucleic acid molecule comprising: (a) a nucleotide sequence as shown in SEQ ID No. 35; or (b) a nucleotide sequence which is the complement of SEQ ID No. 35; or (c) a nucleotide sequence which is degenerate with SEQ ID No. 35; or (d) a nucleotide sequence hybridising under conditions of high stringency to SEQ ID No. 35, to the complement of SEQ ID No. 35, or to a hybridisation probe derived from SEQ ID No. 35 or the complement thereof; or (e) a nucleotide sequence having at least 80% sequence identity with SEQ ID No. 35; or (f) a nucleotide sequence having at least 65% sequence identity with SEQ ID No. 35 wherein said sequence preferably encodes or is complementary to a sequence encoding a nystatin PKS enzyme or a part thereof. Also provided are part of such molecules and polypeptides (and parts thereof) encoded by such a nucleic acid molecule, and the use of such molecules and polypeptides in facilitating nystatin biosynthesis and in the synthesis of nystatin derivatives and novel polyketide as macrolide structures. | 2010-08-26 |
20100216871 | USE OF COMPOUNDS HAVING CCR ANTAGONISM - It is intended to provide preventives/remedies for graft-versus-host disease and/or rejection in organ or bone marrow transplantation, rheumatoid arthritis, autoimmune diseases, allergic diseases, ischemic cerebral cell injury, myocardial infarction, chronic nephritis and arteriosclerosis. The above object can be achieved by preventives/remedies for graft-versus-host disease and/or rejection in organ or bone marrow transplantation, rheumatoid arthritis, autoimmune diseases, allergic diseases, ischemic cerebral cell injury, myocardial infarction, chronic nephritis and arteriosclerosis characterized by containing a specific compound having a CCR (CC chemokine receptor) antagonism. | 2010-08-26 |
20100216872 | PLANT EXTRACT FROM LOW-THC CANNABIS FOR THE TREATMENT OF DISEASE - The present invention relates to a plant extract from a low-tetrahydrocannabinol (THC) variety of | 2010-08-26 |
20100216873 | 5-Hydroxy-2-Methyl-4H-Pyran-4-One Esters as Novel Tyrosinase Inhibitors - Skin brightening compositions based on esters of 5-hydroxy-2-methyl-4H-pyran-4-one. Also disclosed are methods of making the compositions as well as methods of using the compositions. | 2010-08-26 |
20100216874 | HYDROXYTYROSOL-RICH COMPOSITION FROM OLIVE VEGETATION WATER AND METHOD OF USE THEREOF - The invention provides olive-derived hydroxytyrosol. According to one aspect of the invention, vegetation water is collected from olives. Acid is added to stabilize the vegetation water and prevent fermentation. The mixture is incubated to allow oleuropein to convert to hydroxytyrosol, and then fractionated to separate hydroxytyrosol from other components. The hydroxytyrosol is useful as a therapeutic and anti-oxidant for a variety of health purposes, including for the treatment of skin damage. In addition, the hydroxytyrosol is useful as a natural anti-bacterial, anti-viral and fungicidal product for agricultural and pest control applications. | 2010-08-26 |
20100216875 | METHODS OF TREATING ALZHEIMER'S DISEASE - The invention is directed to a method of treating Alzheimer's disease. The method comprises administering a cysteine protease inhibitor to a patient and thereby affecting the disease. In a preferred method, the cysteine protease inhibitor is a cathepsin B inhibitor. A preferred method causes a reversal in the progression of the Alzheimer's disease, especially an improvement in cognitive deficit. A preferred method also causes a reduction in Aβ. The method includes using a reversible or irreversible cysteine protease inhibitor or a combination thereof. | 2010-08-26 |
20100216876 | ANTIDIARRHETIC COMPOSITION, PRODUCT CONTAINING THE SAME AND METHOD OF PREVENTING DIAHHREA - An antidiarrhetic composition is provided which is efficacious against diarrhea, in particular, the predominant secretory diarrhea; an antidiarrhetic medicinal composition containing the same is also provided; a food containing the antidiarrhetic composition is also provided; and a method of preventing diarrhea using the same is also disclosed. The composition for relieving diarrhea is a cool composition capable of acting on the digestive tract in the recipient's body and inhibiting the secretion of the intestinal Cl | 2010-08-26 |
20100216877 | Storage Stable Prostaglandin Product - A prostaglandin composition comprising prostaglandin and a low-density polyethylene container are disclosed. The prostaglandin compositions are stable in polyethylene containers over longer period of time. | 2010-08-26 |
20100216878 | Amino Acid Derivatives - The compound 3,3-dimethyl-butyric acid 4-((S)-2-amino-2-methoxycarbonyl-ethyl)-2-(3,3-dimethyl-butyryloxy)-phenyl ester of formula (I) has dopaminergic properties. | 2010-08-26 |
20100216879 | Resveratrol Ferulate Compounds And Compositions - Resveratrol ferulate compounds and compositions. | 2010-08-26 |
20100216880 | TRANSDERMAL COMPOSITIONS FOR ANTICHOLINERGIC AGENTS - The present invention relates generally to compositions or formulations for transdermal or transmucosal administration of anticholinergic agents such as oxybutynin. The invention utilizes a novel delivery vehicle and is a substantially malodorous-free and irritation free transdermal formulation which is substantially free of long chain fatty alcohols, long-chain fatty acids, and long-chain fatty esters. A method is disclosed for treating a subject for urinary incontinence with these formulations while reducing the incidences of peak concentrations of drug and undesirable side effects associated with oral anticholinergics. | 2010-08-26 |
20100216881 | Enhydrazone esters for treating asthma, allergy and inflammation - The enhydrazone esters for treating asthma, allergy, and inflammation relate to the use of two cyclohexenone derivatives and pharmaceutically acceptable salts thereof in the treatment of asthma, allergies, and inflammation. The esters have the formula: | 2010-08-26 |
20100216882 | ASPIRIN-TRIGGERED LIPID MEDIATORS - Aspirin triggered lipid mediators (ATLMs) are disclosed which are useful for the treatment of prevention of inflammation associated with diseases, including ischemia. | 2010-08-26 |
20100216883 | METHOD OF USING ABSCISIC ACID TO TREAT AND PREVENT DISEASES AND DISORDERS - Methods and compositions for treating inflammatory bowel disease, gastrointestinal inflammation and maintaining normal gut health are described. These methods of the invention involve the administration of abscisic acid in amounts sufficient to alter the expression or activity of PPAR gamma in a cell. Also described are methods for suppressing the expression of cellular adhesion molecules in the gut and methods for increasing CTLA-4 expression on CD4+ T cells through administration of abscisic acid. | 2010-08-26 |
20100216884 | NITRATED-FATTY ACIDS MODULATION OF TYPE II DIABETES - Nitro oleic acid and related metabolites are agonists of PPAR-γ. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-γ, relative to nitro linoleic acid. Thus, nitro oleic acid and its metabolites, as well as their pharmaceutically acceptable salts and prodrug forms, are candidate therapeutics for the treatment of type-2 diabetes, which results from insulin resistance accompanying the improper functioning of PPAR-γ. | 2010-08-26 |
20100216885 | Orodispersible composition comprising polyunsaturated fatty acids without bad odor or taste - An orodispersible composition without bad odor, smell, or taste comprising polyunsaturated fatty acids (PUFA) and a disintegrant. The disintegrant is a solid dispersion comprising mannitol, xylitol, microcrystalline cellulose, crospovidone and dibasic calcium phosphate. A process of preparing the composition and its use as nutritional or dietary supplement for balancing the blood lipid level, preventing or reducing the risk of the development of atherosclerotic changes, disorders or diseases. | 2010-08-26 |
20100216886 | POLYMORPHS OF N2-(1,1'-BIPHENYL-4-YLCARBONYL)-N1-[2-(4-FLUOROPHENYL)-1,1-DIMETHYLETHYL]- -L-ALPHA-GLUTAMINE - Disclosed are novel polymorphic forms of N | 2010-08-26 |
20100216887 | INTRATHECAL BACLOFEN PHARMACEUTICAL DOSAGE FORMS WITH FEWER DEGRADATION PRODUCTS - The present invention relates generally to a sterile, particulate-free, stable intrathecal baclofen solution with less than 0.5% 4-(4-chlorophenyl)-2-pyrrolidone, a degradation product. These solutions are stable under a variety of storage conditions and for extended periods of time. Also disclosed are methods for preparing such compositions. | 2010-08-26 |
20100216888 | LIQUID COMPOSITIONS CONTAINING SOLUBILIZED BENZOYL PEROXIDE, MEANS FOR APPLYING SAME AND METHODS OF TREATMENT USING SAME - Liquid medicaments incorporate about 1.0-3.0% active benzoyl peroxide (BP) by weight in substantially fully solubilized form, while being substantially free of acetone and other harsh, dermatologically undesirable solvents. The novel compositions are produced by (a) creating an emulsion or slurry of BP in an emollient, topically acceptable ester, and (b) dissolving the emulsion or slurry in absolute alcohol. The medicaments may be used in the treatment of BP-responsive skin conditions in mammals, e.g., acne vulgaris or rosacea. The novel medicaments may be dispensed directly to the affected skin area through the use of an applicator device comprising a fluid reservoir associated with a foam applicator tip, or via a spray dispenser, atomizer or pump spray. | 2010-08-26 |
20100216889 | PROLONGED EFFECT DISINFECTANT CLEANSER - The present invention relates to cleanser compositions, and their uses, wherein the cleanser compositions comprise one or more cationic antiseptic agents, a film-forming cationic emulsifying agent, a dispersing auxiliary solvent, a solvent system, and optionally an alkanediol. | 2010-08-26 |
20100216890 | Disinfectant - Disinfectant compositions, containing (a) at least one amine and/or quaternary salt of the general formula (Ia) or (Ib), respectively, and (b) at least one alkanolamine of the general formula (II), or a corresponding salt. The mass ratio of the components in the formulas (I):(II) is between 20:1 and 1:20. The compositions are characterized by an excellent bactericidal and in particular fungicidal action even in small application concentrations and are suitable for use as both disinfectants and preservative agents. | 2010-08-26 |
20100216891 | AROMATIC ANTIHYPERTENSIVE AGENT, AND METHOD FOR LOWERING BLOOD PRESSURE IN MAMMALS - The present invention provides an antihypertensive agent having a superior antihypertensive action, and a method for lowering blood pressure in mammals by inhalation of such an antihypertensive agent through the nostril. | 2010-08-26 |
20100216892 | Use of synergistically active 1,2-alkanediol mixtures as skin moisture-regulating compositions - Synergistically active mixtures of straight-chain 1,2-alkanediols having 5 to 10 C atoms and their use as skin moisture-regulating compositions are described. Binary and ternary mixtures of 1,2-pentanediol, 1,2-hexanediol and 1,2-octanediol have proved to be particularly active here. Cosmetic or pharmaceutical formulations and ready-to-use cosmetic or pharmaceutical products comprising particularly synergistically active mixtures of the 1,2-alkanediols mentioned and the use of these formulations and products are furthermore described. | 2010-08-26 |
20100216893 | Long-term stable pharmaceutical preparation containing the active ingredient glycerol trinitrate - A pharmaceutical preparation containing the active substance glyceryl trinitrate having improved storage stability in a container. The improved storage stability is achieved by the addition of a proton-absorbing substance either as part of the preparation as placed into the container or applied to the surface of the preparation's storage container before the remaining components of the preparation are placed into the container. The preparation can preferably be filled into a plastic bottle having a spray pump. | 2010-08-26 |
20100216894 | NOVEL COMPOUNDS PREPARED BY ADDING AN OXETANE DERIVATIVE TO AN ALCOHOL - The invention relates to compositions obtained by the reaction of an alcohol having a variable nature and that can be modified beforehand by the addition of alkylene oxide, and of a substrate characterised by an oxetane pattern and at least one hydroxyl function. | 2010-08-26 |
20100216895 | FOOD GRADE COLOURING AGENT - The present invention relates to a method for the preparation of a food grade colouring agent by drying one or more coloured vegetable materials selected from the group consisting of red cabbage, beetroot, lemon, black currant, red currant, strawberry, blackberry, blueberry, and saffron under conditions resulting in a predetermined colour. The food grade colouring agent thus obtained can be used for the preparation of coloured food, drinks, pharmaceutical, and cosmetic products. | 2010-08-26 |
20100216896 | GAS-LIQUID-SOLID THREE-PHASE SUSPENSION BED REACTOR FOR FISCHER-TROPSCH SYNTHESIS AND ITS APPLICATIONS - A Fischer-Tropsch synthesis three-phase suspension bed reactor (“suspension bed” also called “slurry bed”) and its supplemental systems, may include: 1) structure and dimension design of F-T synthesis reactor, 2) a gas distributor located at the bottom of the reactor, 3) structure and arrangement of a heat exchanger members inside the reactor, 4) a liquid-solid filtration separation device inside reactor, 5) a flow guidance device inside reactor, 6) a condensate flux and separation member located in the gas phase space at the top of reactor, 7) a pressure stabilizer, a cleaning system for the separation device; an online cleaning system for the gas distributor; an ancillary system for slurry deposition and a pre-condensate and mist separation system located at the outlet of upper reactor. This reactor is suitable for industrial scale application of Fischer-Tropsch synthesis. | 2010-08-26 |
20100216897 | PROCESS FOR THE PREPARATION OF DIMETHYL ETHER - Process for the preparation of dimethyl ether by catalytic conversion of synthesis gas to dimethyl ether comprising contacting a stream of synthesis gas comprising carbon dioxide with one or more catalysts active in the formation of methanol and the dehydration of methanol to dimethyl ether, to form a product mixture comprising the components dimethyl ether, carbon dioxide and unconverted synthesis gas, washing the product mixture comprising carbon dioxide and unconverted synthesis gas in a first scrubbing zone with a first solvent rich in dimethyl ether and subsequently washing the effluent from the first scrubbing zone in a second scrubbing zone with a second solvent rich in methanol to form a vapour stream comprising unconverted synthesis gas stream with reduced content of carbon dioxide, transferring the vapour stream comprising unconverted synthesis gas stream with reduced carbon dioxide content for further processing to dimethyl ether. | 2010-08-26 |
20100216898 | PROCESS AND PLANT FOR PRODUCTION OF BIOFUELS - The invention concerns a method and a plant for producing hydrocarbon based fuels from waste and biomass including wood and/or other cellulose containing biomass, where biomass and/or waste is gasified in anaerobic conditions, heating the formed syngas in for decomposition and subsequent condensation in anaerobic conditions, subjecting the heat treated biosyngas to cleaning measures for removing elements/compounds which are poisonous towards the catalysts of the Fischer-Tropsch synthesis, and passing the cleaned heat treated biosyngas through a Fischer-Tropsch synthesis for production of biofuels. | 2010-08-26 |
20100216899 | POLYAMIDE MEMBRANES WITH FLUOROALCOHOL FUNCTIONALITY - A polymeric membrane includes an active layer on a support. The active layer includes a polymer with a backbone, and the backbone has attached thereto at least one fluoroalcohol moiety. | 2010-08-26 |
20100216900 | Polymers with benzoxazine groups in their main chains - The present invention discloses polymers prepared through the Diels-Alder reaction with benzoxazine groups in their main chains. Moreover, polymers with high molecular weight could be successfully prepared via this method. Furthermore, the mentioned polymers are able to undergo crosslinking reaction by heat treatment. Heat energy causes the ring-opening reaction of benzoxazine in polymer main chains to undergo crosslinking reaction, and cross-linked polymers are thereby formed with great flexibility and high crosslinking degree. | 2010-08-26 |
20100216901 | Polymer electrolyte membrane comprising alkylether graft chain and method of producing the same - A method of producing an electrolyte membrane for use in a fuel cell, including: performing radiation-induced graft polymerization of a vinyl monomer having a nucleophilic functional group selected from an acylvinyl ether derivative, a styrene derivative, and a methacrylic acid derivative, with a polymer substrate having a fluorine-containing polymer, an olefin-containing polymer, or an aromatic polymer; deprotecting an ester bond of a graft chain on the polymer substrate introduced by the radiation-induced graft polymerization; and introducing an alkylethersulfonic acid structure into the nucleophilic functional group of the graft chain thus deprotected, by use of an electrophilic reagent selected from cyclic sulfonic acid ester and alkylhalide sulfonate. | 2010-08-26 |
20100216902 | Method for the pretreatment, reprocessing or recycling of thermoplastic material - The invention relates to a method for the pretreatment, reprocessing or recycling of thermoplastic material, wherein the plastic material to be treated is heated in at least one receptacle or reactor while undergoing constant mixing or movement and/or comminution at a temperature below the melting temperature of the plastic material, and as a result is at the same time crystallized, dried and/or purified, wherein at least one rotatable comminuting or mixing tool, with working edges that act on the material with a comminuting and/or mixing effect, is used for the mixing and/or heating of the plastic material, the heating taking place in particular by applying mechanical energy. | 2010-08-26 |
20100216903 | FOAM-FORMING SYSTEM WITH REDUCED VAPOR PRESSURE - An isocyanate-reactive composition containing a blowing agent that includes HFC 134a and water characterized by a vapor pressure which is lower than that of comparable compositions which do not include the stabilizing composition of the present invention. The stabilizing composition of the present invention includes an ethoxylated nonylphenol and propylene carbonate. This stabilizing composition is included in the isocyanate-reactive composition in an amount sufficient to promote the solubility of the blowing agent. The isocyanate-reactive composition may be stored at ambient conditions rather than under pressure and may be hand mixed with an isocyanate to produce a foam. The isocyanate-reactive composition containing blowing agent of the present invention may be used to produce foams having good physical properties after storage at ambient temperature and pressure for periods as long as 3 months. | 2010-08-26 |
20100216904 | FOAM-FORMING COMPOSITIONS CONTAINING MIXTURES OF 2-CHLORO-3,3,3-TRIFLUOROPROPENE AND AT LEAST ONE HYDROFLUOROOLEFIN AND THEIR USES IN THE PREPARATION OF POLYISOCYANATE-BASED FOAMS - Foam-forming compositions are disclosed which contain a mixture of 2-chloro-3,3,3-trifluoropropene and at least one hydrofluoroolefin. Also disclosed is a closed-cell polyurethane or polyisocyanurate polymer foam prepared from reaction of an effective amount of the foam-forming composition with a suitable polyisocyanate. Also disclosed is a process for producing a closed-cell polyurethane or polyisocyanurate polymer foam by reacting an effective amount of the foam-forming composition with a suitable polyisocyanate. | 2010-08-26 |
20100216905 | POLYURETHANE RESIN - Disclosed is a polyurethane resin which is obtained by a reaction between a polyisocyanate component, which contains 1,4-bis(isocyanatomethyl)cyclohexane including not less than 80% by mole of trans isomers, and an active hydrogen compound component. | 2010-08-26 |
20100216906 | MONOLITH SEPARATION MEDIUM FOR CHROMATOGRAPHIC USE AND METHOD OF PRODUCING THE SAME - A monolith separation medium comprising a skeletal phase and continuous pores forming a three-dimensional network structure, which has a functional group enabling the introduction of a new functional group on the surface of the skeletal phase. The skeletal phase has an average diameter of a submicron to micrometer size and is in a co-continuous structure of the non-particle-aggregation type. It is composed of an addition polymer of 1,3-bis(N,N′-diglycidylaminomethyl)cyclohexane as an epoxy compound with a bifunctional or higher amine compound, is rich in organic matters and is free from any aromatic-origin carbon atom. Thus, it is an organic polymer monolith separation medium of the non-particle-aggregation type. | 2010-08-26 |
20100216907 | ONE-PACKAGE TYPE TOOTH SURFACE COATING MATERIAL - [Problems] To provide a one-package type tooth surface coating material that is capable of forming, on the surface of a tooth, a cured film having not only a very high strength of adhesion to the tooth surface but also excellent properties such as long-term adhesion, long-term durability, dentinal tubule occlusion and aesthetic appearance, and that has excellent storage stability and can be stored in the form of one package. | 2010-08-26 |
20100216908 | Antimicrobial Polymer Nanocomposites - A method of preparing a polymer nanocomposite having antimicrobial properties, comprises (i) contacting a polymeric antimicrobial agent with a clay to form an organoclay; and (ii) subsequently dispersing the organoclay in a polymeric matrix. Polymer nanocomposites prepared by the method of the invention are not prone to leaching of the polymeric antimicrobial agent from the composite, and have many applications. | 2010-08-26 |
20100216909 | BIODEGRADABLE COMPOSITION, PREPARATION METHOD AND THEIR APPLICATION IN THE MANUFACTURE OF FUNCTIONAL CONTAINERS FOR AGRICULTURAL AND/OR FORESTRY USE - The present invention is a formulation for the production of a biodegradable container based on polylactic acid, lignocellulose fibers, lubricating additives, plastifiers, crystallinity modifiers, compatibilizers and functional additives. The lignocellulose fibers can be wood fibers and/or grape marc fibers, with a content that can vary between 0% and 75% of the mixture in weight; the polylactic acid content can vary between 0% and 80% of the mixture in weight; and the content of lubricating additives, plastifiers, crystallinity modifiers, compatibilizers and functional additives can vary between 0% and 10% of the mixture in weight. | 2010-08-26 |
20100216910 | FUNCTIONALIZED POLYMERS AND IMPROVED TIRES THEREFROM - A functionalized elastomer defined by the formula | 2010-08-26 |
20100216911 | Method of Preparing a Nanoparticle Dispersion of a Modified Metal Oxide - The present invention relates to a method of preparing polymer compositions comprising modified metal oxides in a polymer wherein a nanoparticle dispersion of a metal oxide in a non-aqueous solvent is combined with at least one coupling agent to form a nanoparticle dispersion of a modified metal oxide in the non-aqueous solvent. The nanoparticle dispersion is then combined with a polymer followed by the removal of the non-aqueous solvent or, alternatively, combined with a monomer, which is polymerized to form the polymer and removal of the solvent, in any order. Also disclosed are polymer compositions prepared by this method. | 2010-08-26 |
20100216912 | TRANSPARENT HYBRID SHEET - There is provided a transparent hybrid sheet having superior transparency and thermal resistance and having smaller linear expansion coefficient and optical anisotropy and higher degree of flatness. In a transparent hybrid sheet obtained by curing a hybrid composition including an epoxy resin composition containing alicyclic epoxy compound and a curing agent and curing a glass filler together, the alicyclic epoxy compound contains, as a principal component thereof, a diepoxybicyclohexyl compound represented by Formula (1) below, with amounts of isomers of the diepoxybicyclohexyl compound being 20% or less, of a sum of the diepoxybicyclohexyl compound and the isomers, in terms of a ratio of its peak area determined by a gas chromatography. | 2010-08-26 |
20100216913 | Curable Epoxy Resin Composition and Cured Product Thereof - A curable epoxy resin composition comprising: (I) a curable epoxy resin; (II) an epoxy-resin curing agent; and (III) a silicone rubber powder obtained by curing a condensation-curable silicone rubber composition in a dispersed state in water, the powder having an epoxy equivalent measured by titration equal to or lower than 3,000 and an average particle size in the range of 0.1 to 100 μm, possesses excellent flowability and which, when cured, forms a cured product that in spite of low modulus of elasticity possesses high strength. | 2010-08-26 |
20100216914 | POLYCARBONATE CONTAINING PLANT-DERIVED COMPONENT AND PROCESS FOR THE PREPARATION THEREOF - A process for the preparation of a polycarbonate containing a plant-derived component excellent in hue by using a plant-derived anhydrosugar alcohol represented by the following formula (1) or a composition thereof as a raw material: | 2010-08-26 |
20100216915 | Levulinic acid ester derivatives as reactive plasticizers and coalescent solvents - The present invention is directed to ester derivatives of levulinic acid that are useful as plasticizers and/or coalescent solvents in polymer compositions, compositions comprising the ester derivatives, methods of making the derivatives and the compositions, and the use of the derivatives as additives in polymer compositions. | 2010-08-26 |
20100216916 | METHYLENE BLUE - Composition comprising a polymerizable compound with at least one conjugated unsaturated group and methylene blue to prevent premature polymerization of the polymerizable compound. The methylene blue is present in a concentration of 10 to 5000 ppm. | 2010-08-26 |
20100216917 | ALIPHATIC POLYCARBONATES FOR USE IN THERMOSETTING POWDER COATINGS - A thermosetting polymer material capable of being used in powder coatings. The thermosetting polymer material includes at least one hydroxyl functional aliphatic polycarbonates that is formulated and crosslinked with isocyanates to yield a thermoset organic coating material. These materials provide improved weatherability as compared to prior art powder coating materials while also being less expensive than prior art materials utilizing fluorinated polymers. | 2010-08-26 |
20100216918 | FLAME-PROOFED THERMOPLASTIC COMPOSITIONS - Flame-proofed thermoplastic compositions include organophosphorus compounds as flame retardants; thermoplastic articles shaped therefrom do not experience deterioration of the appearance of the surfaces thereof by corrosion or deposition. | 2010-08-26 |