35th week of 2014 patent applcation highlights part 45 |
Patent application number | Title | Published |
20140242098 | DRUG DISPENSING AND DOSING METHOD AND DEVICE - Flexible film or strip dosing device and method for various therapeutic applications are disclosed. The device includes at least one film or strip and a packaging container for the film or strip. The film or strip normally include a polymer base with or without a therapeutic agent admixed with the polymer base. The film or strip is printed with doses, marks or calibrated lines to indicate different length of the film and therefore the different doses of the therapeutic agents. The packaging container or dispenser can have marks or calibrated lines similar to a ruler which measures the length of film and therefore the different doses of therapeutic agents. The packaging container may have a built-in cutter to conveniently cut the film or strips as needed for flexible dosing of therapeutic agents. | 2014-08-28 |
20140242099 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES - The invention relates to certain compounds or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders. | 2014-08-28 |
20140242100 | METHODS AND COMPOSITIONS FOR THE GENERATION AND USE OF CONFORMATION-SPECIFIC ANTIBODIES - The present invention features methods and compositions for the generation of conformation-specific antibodies. | 2014-08-28 |
20140242101 | PD-L1 BASED IMMUNOTHERAPY - The present invention relates to the field of prophylaxis and therapy of clinical conditions including cancer, autoimmune diseases and infectious diseases. In particular there is provided vaccine compositions comprising PD-L1 or peptide fragments thereof that are capable of eliciting immune responses useful in treatment of cancer, autoimmune diseases or infectious diseases. | 2014-08-28 |
20140242102 | INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS - Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided. | 2014-08-28 |
20140242103 | COMPOSITION - The present invention provides a modified influenza virus wherein the RNA of the haemagglutinin gene has been modified such that the haemagglutinin signal sequence is not expressed and the virus produces a haemagglutinin protein that lacks a functional signal sequence. The invention further provides composition comprising the modified virus and uses of the modified virus. | 2014-08-28 |
20140242104 | SELF-ASSEMBLING PEPTIDE NANOPARTICLES AS VACCINES AGAINST INFECTION WITH NOROVIRUS - Self-assembling peptide nanoparticles (SAPN) incorporating T-cell epitopes and displaying the P domain of the norovirus protein VP1 are described. The nanoparticles of the invention consist of aggregates of a continuous peptide chain comprising two coiled coil oligomerization domains connected by a linker segment wherein one or both oligomerization domains incorporate T-cell epitopes within their peptide sequence. These nanoparticles are useful as vaccines and adjuvants for the prevention and treatment of norovirus infections. | 2014-08-28 |
20140242105 | VACCINES FOR CHLAMYDIA - The present invention relates to means and methods to protect against disease caused by bacteria belonging to the genus | 2014-08-28 |
20140242106 | STAPHYLOCOCCUS AUREUS PROTEINS AND NUCLEIC ACIDS - The invention provides proteins from | 2014-08-28 |
20140242107 | Direct Protein Delivery with Engineered Microvesicles - The present invention relates to direct protein delivery with engineered micro vesicles. | 2014-08-28 |
20140242108 | Conjugated TLR7 and/or TLR8 and TLR2 polycationic agonists - A conjugated compound of Formula I: Q-Z—R | 2014-08-28 |
20140242109 | METHOD FOR CULTIVATING ALGA AND METHOD FOR PRODUCING ALGINIC ACID-CONTAINING COMPOSITION - The objective of the present invention is to provide a method for cultivating an alga having ability to produce alginic acid industrially and effectively and a method for producing an alginic acid-containing composition industrially advantageously. The method for cultivating an alga according to the present invention is characterized in comprising the step of cultivating the alga heterotrophically, wherein the alga belongs to the genus | 2014-08-28 |
20140242110 | Dose, localization, and formulation of botulinum toxins in skin and muscle - Formulations of and dosing protocols for the administration of botulinum toxin that maximize efficacy and specificity while minimizing the likelihood of overdosing and undesirable side effects of treatment. The formulations include positively charged carriers, such as cationic peptides, which otherwise have no inherent botulinum-toxin-like activity. The dosing regimen is based on the pattern, quantity, and location of neuromuscular junctions in the target tissue. Because the number of neuromuscular junctions in a target tissue remains generally stable throughout life and because the pharmacological effect of botulinum toxin is localized at the neuromuscular junction, dosing efficacy is unaffected by muscle mass, age of the patient, or body weight. | 2014-08-28 |
20140242111 | Engineered Bacteria for Oral Delivery of Glucoregulatory Proteins - Disclosed is an oral delivery system that overcomes major barriers encountered in the gastrointestinal tract, particularly rapid proteolytic degradation and low intestinal permeability. Provided is a method for oral delivery of an engineered microorganism to a mammal where the microorganism produces a macromolecule having a desired bioavailability outcome. | 2014-08-28 |
20140242112 | NOVEL VACCINE - The present invention provides an immunogenic composition comprising one or more antigens and a Toll-like receptor (TLR) 7 agonist in an orally (e.g. sublingually) administered composition. | 2014-08-28 |
20140242113 | LIQUID VACCINE PREPARATIONS - This document provides methods and materials involved in making and using liquid vaccine preparations for oral administration. For example, methods and materials for making and using liquid vaccine preparations for oral administration that include a lyophilized or dried vaccine component (e.g., a lyophilized pathogenic agent such as a lyophilized rotavirus preparation) and a liquid edible oil composition (e.g., a liquid edible oil composition containing one or more medium chain triglycerides) are provided. In some cases, liquid vaccine preparations that include a buffer component (e.g., CaCO | 2014-08-28 |
20140242114 | cDNA CONSTRUCT OF SALMONIDAE ALPHAVIRUS - The invention concerns recombinant DNA's comprising cDNA of genomic RNA of a Salmonidae alphavirus preceded by a spacer sequence, under the control of a suitable promoter. Said recombinant DNAs are useful for obtaining expression vectors, producing recombinant Salmonidae alphavirus, and for obtaining vaccines. | 2014-08-28 |
20140242115 | INACTIVATING PATHOGENS WITH OXIDIZING AGENTS FOR VACCINE PRODUCTION - The present disclosure provides methods for producing a vaccine composition containing a pathogen that is rendered noninfectious by exposure to hydrogen peroxide. The methods disclosed herein are suitable for the preparation of vaccines for a wide variety of pathogens, including viruses, bacteria and parasites. The disclosure also provides vaccine compositions (medicaments) containing a pathogen inactivated by exposure to hydrogen peroxide. Methods for eliciting an immune response in a subject by administering vaccine compositions containing a hydrogen peroxide inactivated pathogen are also provided. | 2014-08-28 |
20140242116 | Spray Dried Compositions and Methods of Use - Provided herein are insoluble particles that include polypeptides. The polypeptides may have immunogenicity that is greater than the immunogenicity of the same polypeptides when they are not present in the particle. The polypeptides may be soluble before incorporation into the particles and insoluble after incorporation into the particles. The particles may include lipopolysaccharide, wherein the lipopolysaccharide is insoluble. The particles may include a carrier. In one embodiment, a carrier is present at no greater than 0.001 mg carrier/mg particles. In one embodiment, a carrier is present at a ratio of carrier to polypeptide (weight:weight) of no greater than 0.05:1. In one embodiment, a carrier is not detectable in the particles. | 2014-08-28 |
20140242117 | Vaccine Composition Capable of Inducing Memory Antibody Response from Single Point Immunization - The present investigation relates to entrapment of carbohydrate antigen such as Vi polysaccharide of | 2014-08-28 |
20140242118 | Tumor Vaccination in Combination with Hematopoietic Cell Transplantation for Cancer Therapy - In one aspect, the present invention provides a method for treating cancer comprising tumor cell vaccination in combination with hematopoietic and immune cell transplantation. In some embodiments, the method involves autologous tumor cell vaccination prior to autologous hematopoietic and immune cell transplantation. In another aspect, the present invention provides a method of purifying tumor cells from a subject in preparation for vaccination. | 2014-08-28 |
20140242119 | AMINO ALCOHOL DERIVATIVES FOR THE TREATMENT OF DEMYELINATING PERIPHERAL NEUROPATHIES - The invention provides the use of compound of formula V or formula VI in the treatment of a demyelinating peripheral neuropathy: | 2014-08-28 |
20140242120 | SUBSTITUTED AROMATIC COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES - The invention relates to compounds of structural formula (I): | 2014-08-28 |
20140242121 | NOVEL IMIDAZOLE QUINOLINE-BASED IMMUNE SYSTEM MODULATORS - The present invention relates to a compound of Formula I: or an enantiomer, diastereomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same; and a method for treating or preventing autoimmunity disease using the same. | 2014-08-28 |
20140242122 | Crystalline Glycopyrrolate Tosylate - Salts of glycopyrrolate, including solid forms thereof are herein disclosed. Methods of making glycopyrrolate salts and methods of treating hyperhidrosis with salts of glycopyrrolate are disclosed. | 2014-08-28 |
20140242123 | SACCHARIDE-PEPTIDE HYDROGELS - The disclosure provides for saccharide-peptide based hydrogels, the functionalization of the saccharide-peptide based hydrogels with one or more biological agents, and the encapsulation of one or more biological materials and/or pharmaceutical agents in the hydrogels. The disclosure further provides for the use of the saccharide-peptide based hydrogels in treating a disease or disorder in a subject. | 2014-08-28 |
20140242124 | Agonists of Guanylate Cyclase and Their Uses - This invention provides a method of colonic cleansing. | 2014-08-28 |
20140242125 | MUSCLE TISSUE REGENERATION USING MUSCLE FIBER FRAGMENTS - The invention is directed to methods and compositions for obtaining uniform sized muscle fiber fragments for transplantation. These muscle fiber fragments are able to reconstitute into long fibers that are oriented along native muscle. The implanted muscle cells integrate with native vascular and neural network, as confirmed by histology and immunohistochemistry. This invention is particularly advantageous because autologous muscle can be harvested from a donor site, processed and injected into target sites in the operating room. The fragmented muscle fibers can be readily integrated within the host. | 2014-08-28 |
20140242126 | Dendritic Macroporous Hydrogels Prepared By Crystal Templating - The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel. | 2014-08-28 |
20140242127 | Compositions With Thermally-Regulating Material - Cosmetic compositions for topical application to the skin comprising at least one phase change material (PCM) in combination with a cosmetically compatible carrier, and methods for maintaining the skin of a wearer of a cosmetic product at a comfortable temperature, are provided. | 2014-08-28 |
20140242128 | COMPOSITE POWDER AND METHOD FOR PRODUCING SAME - An object of the present invention is to provide a composite powder that is stable even if it is present in water for a long time. A composite powder, comprising: an inorganic powder; a first coating layer containing a water-repellent organic compound on the surface of the inorganic powder; and a second coating layer which contains at least one compound selected from the group consisting of silicon oxide, silicon oxide hydrate, aluminum oxide, and aluminum hydroxide, and which is formed on the first coating layer. | 2014-08-28 |
20140242129 | PHOTOPROTECTIVE PERSONAL CARE COMPOSITION - A photoprotective personal care composition. The invention to a photoprotective personal care composition. The invention more particularly relates to a sunscreen composition that not only provides high sun protection but does that with minimal or no amount of traditionally used organic sunscreens. It is thus objects of the present invention to obviate the drawbacks of the prior art and provide high SPF photo-protective sunscreen compositions. Another object of the present invention is to achieve the above object using negligible amounts or no amount of organic sunscreen agents, which are sometimes unstable with the added advantage that inclusion of low or no organic sunscreens enables low formulation cost. | 2014-08-28 |
20140242130 | SEAWEED-DERIVED COSMETIC COMPOSITIONS - A cosmetic composition is disclosed for applying to skin. The composition includes a liquid and dispersed in the liquid: any amount or form of fucoidan, any amount or form of beta glucan; and any amount of a marine extract. When the cosmetic composition is applied to the skin, the appearance of the skin is improved. | 2014-08-28 |
20140242131 | Composition Containing a Cellulose Derived Capsule With a Sunscreen - A sunscreen composition comprised of one or more sunscreen active agents encapsulated in a cellulose derived capsule wherein the composition can contain one or more additional agents. A sunscreen composition can be mixed with a bodywash, shampoo, conditioner, lotion, gel, soap, cream, hand sanitizer, spray or mousse and can be used by an individual during their normal hygiene processes, such as during a shower or bath or while applying a body product to their skin or hair. | 2014-08-28 |
20140242132 | Composition Containing a Cellulose Derived Capsule With a Sunscreen - A sunscreen composition comprised of one or more sunscreen active agents encapsulated in a cellulose derived capsule wherein the composition can contain one or more additional agents. A sunscreen composition can be mixed with a bodywash, shampoo, conditioner, lotion, gel, soap, cream, hand sanitizer, spray or mousse and can be used by an individual during their normal hygiene processes, such as during a shower or bath or while applying a body product to their skin or hair. | 2014-08-28 |
20140242133 | ENCAPSULATED LOW VISCOSITY HYDROPHOBIC LIQUID ACTIVES - The present invention provides personal care compositions, as well as methods for protecting low viscosity hydrophobic liquid actives. | 2014-08-28 |
20140242134 | COSMETIC COMPOSITION - The invention relates to cosmetic compositions comprising a water-in-oil emulsion comprising hydrophobically modified particles, amino functionalized silicone and water; the cosmetic composition further comprising a viscosity modifying agent and optical light modifying agent. The invention further relates to a method of modifying the optical appearance of skin comprising the step of applying to the skin the cosmetic composition of the invention. | 2014-08-28 |
20140242135 | COMPOSITIONS FOR INHIBITION OF INSECT SENSING - In one aspect, the invention relates to chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in airborne insects such as mosquitos. Method of employing such agents, and articles incorporating the same, are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 2014-08-28 |
20140242136 | SPRAY APPARATUSES, USES OF DIATOMACEOUS EARTH, AND METHODS OF CONTROLLING INSECT POPULATIONS - There is disclosed a spray apparatus for holding contents comprising diatomaceous earth and a compressed propellant for propelling the diatomaceous earth. There is also disclosed use of diatomaceous earth to control a population of bedbugs, wherein the diatomaceous earth comprises remains of pennate diatoms. There is also disclosed a method of controlling a population of insects, the method comprising causing a compressed propellant to propel diatomaceous earth on a surface. Method of manufacturing a spray apparatus and methods of preparing diatomaceous earth for use in controlling a population of insects are also disclosed. | 2014-08-28 |
20140242137 | Glycolate Formulation for Preserving Wood and Like Materials - Compositions and methods for use in treating, in particular, lignocellulosic substrates such as lumber, are provided; wherein said compositions comprise a preservative or biocidal species, other than boron, in the form of a glycolate. The methods may be used for the purpose of, for example, preventing the growth of pest organisms, or for providing other specific properties to the substrate. | 2014-08-28 |
20140242138 | Applications Of Microencapsulated Essential Oils - Method for the preparation of microencapsulated essential oils or a formulation thereof for various non-agricultural applications. | 2014-08-28 |
20140242139 | CONTROLLED DRUG DELIVERY - A medical device for placement in a body of a mammal is provided. The medical device comprises (1) a polymeric matrix forming the device and defining a lumen through the device, the matrix comprising polymer macromolecules and defining spaces between the polymer macromolecules; (2) a drug contained within at least some of the spaces of the matrix; and (3) a material contained within at least some of the spaces of the matrix to affect diffusion of the drug out of the polymeric matrix when the medical device is placed in the body of the mammal. | 2014-08-28 |
20140242140 | FABRICATION METHOD FOR STRATIFIED AND LAYERED TISSUE TO REPAIR OSTEOCHONDRAL DEFECTS - Fabrication method for stratified and layered tissue to repair osteochondral defects. In a method of the present disclosure, the method comprises the step of applying a first direction magnetic field to a first quantity of a first collagen solution to align collagen within the first collagen solution in a first direction relative to the first direction magnetic field, forming a first layer of collagen. In a method of generating an aligned collagen layer of the present disclosure, the method comprises applying a first magnetic field at or greater than 0.1 Tesla to a layer of a first collagen solution defining a horizontal plane, within a temperature at or between 2° C. and 45° C., to generate an aligned collagen layer. | 2014-08-28 |
20140242141 | Polymeric/Inorganic Composite Materials for Use in Medical Devices - In one aspect, the present invention provides composite coatings for implantable or insertable medical devices. These composite coatings comprise (a) an inorganic portion and (b) a polymeric portion that comprises a poly(vinyl pyrrolidone) (PVP) block. | 2014-08-28 |
20140242142 | CELL SECRETED PROTEINS FOR THE TREATMENT OF MYOCARDIAL INFARCTION - The present invention relates to the use of secreted proteins from mesenchymal stem cells and other cells for the treatment of myocardial infarction. In particular, the invention provides compositions and methods based on secreted proteins from mesenchymal stem cells and the genes encoding them. | 2014-08-28 |
20140242143 | ADIPOSE STROMAL VASCULAR FRACTION CELL CONSTRUCTS - Three-dimensional tissue constructs are described, which may be created by isolating adipose-derived stromal vascular fraction (SVF) cells, plating the cells onto a polymer scaffold, and culturing the plated scaffold in a culture of DMEM with approximately 10% FBS. | 2014-08-28 |
20140242144 | DRUG ELUTING SCAFFOLD FOR KIDNEY-RELATED DISEASE - Methods of treating renal cancers and other kidney-related inflammatory disorders with a bioabsorbable polymer scaffold (such as a stent) are described. The treatments are provided as alternative to complete or partial surgical removal of a diseased kidney. | 2014-08-28 |
20140242145 | CHITOSAN NANOFIBER FOR ANIONIC PROTEIN DRUG DELIVERY, METHOD OF PREPARING THE SAME, AND PHARMACEUTICAL PREPARATION FOR TRANSMUCOSAL ADMINISTRATION COMPRISING THE CHITOSAN NANOFIBER - A chitosan nanofiber for delivering an anionic protein drug, a method of preparing the same, and a pharmaceutical preparation for transmucosal administration including the chitosan nanofiber are provided. The chitosan nanofiber including an anionic protein drug in a core and chitosan in a shell is prepared by coaxial electrospinning an aqueous solution of the anionic protein drug through an inner nozzle and a solution of the chitosan or a chitosan derivative through an outer nozzle. | 2014-08-28 |
20140242146 | FILAMENT BASED ON HYALURONIC ACID IN THE FORM OF FREE ACID AND METHOD FOR OBTAINING IT - The present invention relates to a method for preparing by wet spinning a continuous filament based on hyaluronic acid in free acid form, notably soluble in water. The preparation method according to the invention comprises the following steps: a) preparing a spinnable aqueous solution of hyaluronic acid or of a hyaluronic acid salt, preferably a sodium hyaluronate solution; b) extruding said solution to an extrusion die; c) forming the filament by passing the extruded solution into a bath of acetic acid, concentrated to more than 80%, drawing and drying. The invention also relates to a filament based on hyaluronic acid in free acid form, said filament having swelling properties in water and physiological liquids and moreover being solubilizable in water under certain conditions. | 2014-08-28 |
20140242147 | ADSORBENTS FOR ORAL ADMINISTRATION - The present invention aims to provide an adsorbent for oral administration comprising ACF that has high adsorption or removal performance by adsorbing or removing toxic substances in the living body greatly and rapidly. The present invention is an adsorbent for oral administration comprising activated carbon fibers for treating or preventing kidney diseases or dialysis complications. | 2014-08-28 |
20140242148 | ANTIMICROBIAL MATERIALS AND METHODS - The invention provides methods and materials for decontamination of surfaces and fabrics, such as non-woven fabrics, that are contaminated with infestations of microorganisms such as bacteria. Biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group can be used to decontaminate infested surfaces in the presence of oxygen and, optionally, illumination. Fibers incorporating biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group, wherein the oligomer is physically associated with or covalently bonded to, or both, the fiber-forming polymer can be used to form non-woven mats. Biocidal non-woven mats prepared by methods of the invention, incorporating the biocidal oligomers, can be used to suppress bacterial growth in wound and surgical dressings and personal hygiene products. | 2014-08-28 |
20140242149 | High-Viscosity Silicone Adhesive - Provided in various embodiments are high viscosity, shear-thinning silicone compositions that can be pattern coated directly onto a substrate and silicone compositions having high-density particles suspended in an adhesive gel. The silicone compositions contain a thixotropic additive, such as a hydrogenated vegetable oil. The silicone compositions may be applied on a substrate for use in medical devices or wound dressings. | 2014-08-28 |
20140242150 | THERAPEUTIC COMPOSITIONS AND METHODS OF TREATMENT WITH CAPSIANOSIDE-TYPE COMPOUNDS - The present invention discloses the use of certain compounds as therapeutic agents, and in particular as analgesics and anti-inflammatory agents. Such compounds include, for example, certain diterpene monoglycosides and diterpene diglycosides. The compounds of the present invention may be synthesized or isolated from the fruit of the genus | 2014-08-28 |
20140242151 | ADHESIVE SKIN PATCH - The present invention provides an adhesive skin patch that permits excellent and prolonged percutaneous absorption of tulobuterol and that can be stably applied to the skin for a long period of time with less skin irritation. The adhesive skin patch comprises a base material and a medicated layer provided on one surface of the base material. The medicated layer contains 1 to 30% by weight of a resolvent, 40 to 98% by weight of a pressure-sensitive adhesive, and tulobuterol. The resolvent contains an aliphatic alcohol having a branched-chain structure or a double bond in its C8 to C30 carbon chain. The pressure-sensitive adhesive is a copolymer obtained by copolymerizing monomers containing 70% by weight or more of an alkyl(meth)acrylate whose alkyl group has 6 to 20 carbon atoms. | 2014-08-28 |
20140242152 | IMMUNOGENIC COMPOSITIONS AND USES THEREOF - This invention generally relates to immunogenic compositions that comprise an RNA component and a polypeptide component. Immunogenic compositions that deliver antigenic epitopes in two different forms—a first epitope from a pathogen, in RNA-coded form; and a second epitope from the same pathogen, in polypeptide form—are effective in inducing immune response to the pathogen. The invention also relates to a kit comprising an RNA-based priming composition and a polypeptide-based boosting composition. The kit may be used for sequential administration of the priming and the boosting compositions. | 2014-08-28 |
20140242153 | NOVEL ENCOCHLEATION METHODS, COCHLEATES AND METHODS OF USE - Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed. | 2014-08-28 |
20140242154 | Compounds, Compositions, Methods, and Kits Relating to Telomere Extension - Compounds and compositions for the transient expression of exogenous telomerase activity in a cell are provided. The compounds and compositions, which relate to a ribonucleic acid coding for a telomerase reverse transcriptase, are useful in the extension of telomeres in cells needing such treatment. Such cells include, for example, cells that contain shortened telomeres and cells from subjects that may benefit from telomere extension, for example subjects that suffer from, or are at risk of suffering from, age-related or other illnesses. Also provided are methods of extending telomeres through the administration of the provided compounds and compositions to animal cells, either in vitro or in vivo, and kits including the compounds or compositions and instructions for use. | 2014-08-28 |
20140242155 | Compounds, Compositions, Methods, and Kits Relating to Telomere Extension - Compounds and compositions for the transient expression of exogenous telomerase activity in a cell are provided. The compounds and compositions, which relate to a ribonucleic acid coding for a telomerase reverse transcriptase, are useful in the extension of telomeres in cells needing such treatment. Such cells include, for example, cells that contain shortened telomeres and cells from subjects that may benefit from telomere extension, for example subjects that suffer from, or are at risk of suffering from, age-related or other illnesses. Also provided are methods of extending telomeres through the administration of the provided compounds and compositions to animal cells, either in vitro or in vivo, and kits including the compounds or compositions and instructions for use. | 2014-08-28 |
20140242156 | LIPOSOMAL MITIGATION OF DRUG-INDUCED LONG QT SYNDROME AND POTASSIUM DELAYED-RECTIFIER CURRENT - Compositions and methods for the treatment of drug-induced long QT syndrome and other cardiac channelopathies are disclosed herein. The compositions and methods of the present invention comprise binding one or more QT prolonging drugs with a liposome prior to parenteral (intravenous or subcutaneous) administration, or administration of an empty liposome prior to or concomitantly with therapeutic agents known to have a high risk of QT prolongation, or immediately following an envenomation. The results presented show an abrogation of the adverse effects of QT prolonging drugs in a dose-dependent manner by the compositions of the present invention. | 2014-08-28 |
20140242157 | EPICATECHIN COMPOSITIONS AND METHODS - Provided herein are methods and compositions for treating a subject who has pulmonary damage or an injury caused by or who is at risk for an injury caused by an anti-vesicant agent. The compositions comprise cacao extracts that include a mixture of epicatechin and one or more epicatechin oligomers and a pharmaceutically acceptable carrier. Also provided are methods for fermenting cacao to enhance epicatechin and antioxidant content. | 2014-08-28 |
20140242158 | Granular Pharmaceutical Composition - The present invention relates to a granular pharmaceutical composition obtained by coating a nucleus with: (1) a layer containing a material having a damp-proofing function, and (2) a drug layer containing linaclotide, a pharmaceutically acceptable salt, or a hydrate thereof, and (3) a layer containing a material having a damp-proofing function. Also, the present invention relates to a method for manufacturing the granular pharmaceutical composition obtained by coating the nucleus with (1) the layer containing the material having a damp-proofing function, (2) the drug layer containing the linaclotide, the pharmaceutically acceptable salt, or the hydrate thereof, and (3) the layer containing the material having a damp-proofing function. | 2014-08-28 |
20140242159 | Method for Preparing a Granulate Formulation of Pirfenidone and Pharmaceutically Acceptable Excipients - A capsule formulation of pirfenidone is provided that includes pharmaceutically acceptable excipients. In one embodiment, this capsule formulation is capable of sustaining desirable pharmacokinetic responses in a patient. Further provided are methods of treating fibrotic conditions and other cytokine-mediated disorders by administering pirfenidone capsules of such formulation to a patient in need. | 2014-08-28 |
20140242160 | CALCIUM SUPPLEMENT - An oral dosage form for administration to an animal comprising a biologically utilizable form of calcium and an extended release system that maintains the calcium level in the animal's bloodstream at a substantially beneficial level for a defined period of time. | 2014-08-28 |
20140242161 | SOFT GELATIN CAPSULES - The present invention relates to soft gelatin capsules characterized in that the shell includes a cyclodextrin and in that the filling material contains a liposoluble drug capable of forming a complex with said cyclodextrin for improving the solubility of the active ingredient upon disintegration of the soft gelatin capsule. | 2014-08-28 |
20140242162 | PHARMACEUTICAL COMPOSITIONS COMPRISING 40 - O - ( 2 - HYDROXY) ETHYL - RAPAMYCIN - The invention relates to extended release pharmaceutical formulations in form of multiparticulates comprising 40-O-(2-hydroxy)ethyl-rapamycin, to dosage forms which comprise said pharmaceutical formulations, to methods of preparing said pharmaceutical formulations and said dosage forms, to uses of said pharmaceutical formulations and said dosage for the manufacture of a medicament for the treatment or prevention of diseases or conditions responsive to inhibition of mTOR signaling pathway, such as for instance proliferative diseases or immunosuppression. | 2014-08-28 |
20140242163 | AMANTADINE COMPOSITIONS AND METHODS OF USE - Methods of nighttime administration of amantadine to reduce sleep disturbances in patient undergoing treatment with amantadine are described, as well as compositions of extended release amantadine that are suitable for nighttime administration. | 2014-08-28 |
20140242164 | COMPOSITION AND METHOD OF OBTAINING ORAL OR ENTERAL DOSAGE FORMS OF PHYTOCHEMICALS FROM POMEGRANATES - Nutraceutical compositions for improved administration of important phytochemicals from pomegranate to a human or animal. More particularly, enables oral or enteral dosage forms containing phytochemicals from pomegranate for administering on a routine basis. In at least one instance the natural contents of a pomegranate are encapsulated into a pill form or concentrated juice that provides for more efficient administration than eating a pomegranate but contains the same key ingredients present in the fruit. Enables the recipient to receive the benefits of the fruit but allows for the dosages to be taken in pill or concentrated juice form. Composition is chemically similar or equal to a natural pomegranate but is in a powder, pill or concentrated liquid form. | 2014-08-28 |
20140242165 | Biocompatible Carrier Containing A Bioadhesive Material - A biocompatible carrier for delivery of a therapeutic substance or an active agent is disclosed. The carrier contains a bioadhesive material allowing for increased residence time of the active agent at the treatment site. | 2014-08-28 |
20140242166 | SUSTAINED RELEASE MATRIX SYSTEMS FOR HIGHLY SOLUBLE DRUGS - Disclosed are sustained release oral solid dosage forms comprising a therapeutically effective amount of a medicament having a solubility of more than about 10 g/l; a pH modifying agent; and a sustained release matrix comprising a gelling agent, said gelling agent comprising a heteropolysaccharide gum and a homopolysaccharide gum capable of cross-linking said heteropolysaccharide gum when exposed to an environmental fluid, said dosage form providing a sustained release of said medicament after oral administration to human patients. | 2014-08-28 |
20140242167 | PHARMACEUTICAL COMPOSITIONS FOR GLUCOCORTICOID REPLACEMENT THERAPY - The invention relates to glucocorticoid replacement therapy and provides pharmaceutical compositions and kits designed to deliver one or more glucocorticoids to a subject in need thereon in a manner that results in serum levels of the glucocorticoid that essentially mimic that of a healthy subject for a clinically relevant period of time. The pharmaceutical compositions and kits are prepared in such a way that a first part of one or more glucocorticoids is substantially immediately released and a second part of one or more glucocorticoids is released over an extended period of time of at least about 8 hours. The invention also relates to a method for treating diseases requiring glucocorticoid treatment such as in subjects having a glucocorticoid deficiency disorder. | 2014-08-28 |
20140242168 | SWELLABLE COATED TABLET - The present invention provides perorally administrable drug release systems and processes for producing perorally administrable systems having a drug-containing core and a sheath which surrounds the core and comprises a swellable shell and an elastic coating which surrounds at least the shell, the sheath having at least one orifice. | 2014-08-28 |
20140242169 | TAPENTADOL COMPOSITIONS - The present invention provides a method of treating pain and pain related conditions by administering to a patient in need thereof, a therapeutically effective amount of a slow release Tapentadol Hydrochloride and therapeutically effective amount of a second analgesic, wherein the second analgesic is gamma-aminobutyric acid (GABA) analogue. The present invention further provides a pharmaceutical composition comprising a therapeutically effective amount of a slow release Tapentadol Hydrochloride and a therapeutically effective amount of a second analgesic, wherein the second analgesic is gamma-aminobutyric acid (GABA) analogue. | 2014-08-28 |
20140242170 | Corticosteroids for the Treatment of Joint Pain - Corticosteroid microparticle formulations are provided for use for treating pain, including pain caused by inflammatory diseases such as osteoarthritis or rheumatoid arthritis, and for slowing, arresting or reversing structural damage to tissues caused by an inflammatory disease, for example damage to articular and/or peri-articular tissues caused by osteoarthritis or rheumatoid arthritis. Corticosteroid microparticle formulations are administered locally as a sustained release dosage form (with or without an immediate release component) that results in efficacy accompanied by clinically insignificant or no measurable effect on endogenous cortisol production. | 2014-08-28 |
20140242171 | OIL-IN-WATER EMULSION OF MOMETASONE AND PROPYLENE GLYCOL - Novel pharmaceutical compositions of mometasone or a pharmaceutically acceptable derivate thereof in the form of an oil-in-water emulsion, notably a cream. The composition has excellent stability and therapeutic effect. The compositions contain mometasone in micronised form, propylene glycol and water and the weight ratio between the propylene glycol and water contained in the oil-in-water emulsion is from 1:1 to about 1:3. | 2014-08-28 |
20140242172 | Solid Forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline- -3-carboxamide - The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith. | 2014-08-28 |
20140242173 | TARGETED SYNTHETIC NANOCARRIERS WITH PH SENSITIVE RELEASE OF IMMUNOMODULATORY AGENTS - This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that encapsulate labile immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. | 2014-08-28 |
20140242174 | TREATING COUGH AND TUSSIVE ATTACKS - The invention is directed towards carcainium in the form of a salt having an anion An | 2014-08-28 |
20140242175 | NANO-ENCAPSULATED, CONTROLLED DRUG DELIVERY, MANUFACTURING PROCESS AND SYSTEM - A mixed dose of a nanosized drug wherein at least one portion of the mixed dose comprises a core nanosized drug encapsulated in at least one layer of a protective material having the same core drug or different core drug. A mixed dose of a nanosized drug wherein at least one portion of the mixed dose comprises a core nanosized drug encapsulated in at least one shell of a protective material with same drug concentration or different drug concentrations. A mixed dose of a nanosized drug wherein at least one portion of the mixed dose comprises a core nanosized drug encapsulated such that to have different release schedule than the other portions of the drug. Methods and systems for the manufacturing and the administration of nanosized encapsulated drugs are also provided. | 2014-08-28 |
20140242176 | COMPOSITIONS, METHODS, AND DEVICES FOR THE TREATMENT OF EYE STAIN - Embodiments provided herein relate to compositions, methods, and devices useful for treating eye stain. More particularly, compositions and devices are provided that include tylosin and a carrier suitable for ophthalmic application. Such compositions and devices can be used to treat eye stain in an animal, such as a dog or cat. | 2014-08-28 |
20140242177 | EPINEPHRINE NANOPARTICLES, METHODS OF FABRICATION THEREOF, AND METHODS FOR USE THEREOF FOR TREATMENT OF CONDITIONS RESPONSIVE TO EPINEPHRINE - The invention provides compositions including epinephrine nanoparticles and methods for therapeutic use of the compositions in the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine nanoparticles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required. Additionally, the invention provides methods for fabrication of stabilized epinephrine nanoparticles for use in the described compositions. | 2014-08-28 |
20140242178 | TASTE-MASKED FORMULATIONS OF RALTEGRAVIR - Disclosed are taste-masked pharmaceutical formulations of raltegravir comprising coated API granules mixed with a screened powder excipient blend in either tablet or sachet form. The core and coated granules are produced using a Wurster process for enhanced control of particle size. Also disclosed are methods of treating HIV, e.g., in pediatric populations. | 2014-08-28 |
20140242179 | NOVEL COATING SYSTEM - The present patent application relates to a novel coating system, coated compositions with such a coating system, as well as to the use of such compositions in the production food, feed, dietary supplements and/or pharmaceutical products, as well as to food, feed, dietary supplements and/or pharmaceutical products comprising such compositions. | 2014-08-28 |
20140242180 | NANOPARTICLES FOR CONTROLLING BLEEDING AND DRUG DELIVERY - A temperature stable nanoparticle is provided comprising a core, a water soluble polymer and a peptide, the water soluble polymer attached to the core at a first terminus of the water soluble polymer, the peptide attached to a second terminus of the water soluble polymer, the peptide comprising an RGD amino acid sequence, the water soluble polymer of having sufficient length to allow binding of the peptide to glycoprotein lib/Ilia (GPIIb/llla). In one aspect, the nanoparticle has a melting temperature over 35° C. In various aspects, the nanoparticle has a spheroid shape and a diameter of less than 1 micron. | 2014-08-28 |
20140242181 | PREPARATION OF FIBRIN GEL FOR USE AS IMPLANT SYSTEM - The present invention aims to generate a fibrin gel for cell proliferation and transport using the patient's own blood or compatible blood. The gel-preparation process consists in taking a quantity of blood from the patient, using sodium citrate as anticoagulant, separating off the citrated plasma by centrifugation, and resuspending the cells to be transported in the plasma. CaCl | 2014-08-28 |
20140242182 | FORMULATIONS THAT STABILIZE PROTEINS - In one aspect, the disclosure provides formulations that stabilize proteins, wherein the formulations comprise a buffer. In some embodiments, the buffer comprises potassium mono-hydrogen-phosphate and potassium di-hydrogen-phosphate, or the buffer comprises sodium mono-hydrogen-phosphate and sodium di-hydrogen-phosphate. In some embodiments, the protein is a therapeutic protein. In some embodiments, the therapeutic protein is antithrombin. | 2014-08-28 |
20140242183 | Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. | 2014-08-28 |
20140242184 | Compositions for Regenerating Defective or Absent Myocardium - Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function. | 2014-08-28 |
20140242185 | Method of Enhancing Health of a Person - A method of enhancing health of a person includes administering stable water clusters to persons having an autoimmune disease, pain, a chronic disease, a mental disease, a genetic disease from malfunction of a normal DNA, being an athlete for improving his performance and alleviating soreness, suffering from overworking, stress and toxins etc., by drinking a solution containing stable water clusters, swallowing small objects which contain the stable water clusters, putting a topical cream which contains the stable water clusters on skin, breathing the stable water clusters through mouth, putting drops which contain the stable water clusters into eyes, ears or nose, cleaning colon with solution that contains the stable water clusters, eating food that contains the stable water clusters, injecting solution that contain the stable water clusters into blood vessel etc. | 2014-08-28 |
20140242186 | GUIDED BONE REGENERATION MEMBRANE AND MANUFACTURING METHOD THEREOF - A guided bone regeneration material is disclosed. The guided bone regeneration material includes biodegradable fibers produced by an electrospinning method. The biodegradable fibers produced by the method include a silicon-releasing calcium carbonate and a biodegradable polymer. The silicon-releasing calcium carbonate is a composite of siloxane and calcium carbonate of vaterite phase. The biodegradable fibers may be coated with apatite. When the guided bone regeneration material is immersed in a neutral aqueous solution, silicon species ions are eluted from the calcium carbonate. The guided bone regeneration material excels in bone reconstruction ability. | 2014-08-28 |
20140242187 | Iron-Fiber Composition, Preparation and Uses Thereof - Compositions comprising ferrous and/or ferric iron compounds and fiber in a complex, methods for preparing such compositions of matter, and the use thereof for treatment of adsorbing certain accessible targets in the gastrointestinal tract and in an extracorporeal system, are provided herein. | 2014-08-28 |
20140242188 | Antimicrobial Compositions and Methods Employing Same - An aqueous composition with a higher-than-neutral pH includes a significant amount of one or more surfactants and large amounts of osmotically active solutes. This composition, as well as an acidic counterpart and solid materials, can be used in a variety of applications such as wound care, oral care, medical equipment reprocessing, healthcare acquired infection and implant treatment. | 2014-08-28 |
20140242189 | METHODS OF TREATING GASTROINTESTINAL SPASMS TRIGGERED BY STRESS - Methods of treating gastrointestinal spasms are provided. For example, methods of treating gastrointestinal spasms are provided, such methods not requiring the use of systemic drugs that have shown to (i) provide slow relief, (ii) cause adverse side effects, (iii) limit activities, (iv) worsen existing gastrointestinal conditions, (v) be unrecommended in several gastrointestinal conditions that include gastrointestinal spasms, or (vi) be unrecommended in the absence of diarrhea. | 2014-08-28 |
20140242190 | USE OF DEOXYELEPHANTOPIN (DET) AND ANALOGUES THEREOF FOR TREATMENT OF MELANOMA - Methods for preventing and/or reducing side effects of an anti-cancer agent in a subject in need thereof are disclosed. The method comprises administering to the subject, who is under an anti-cancer agent treatment, a composition comprising a therapeutically effective amount of isolated deoxyelephantopin and/or an analogue thereof; and a pharmaceutically acceptable carrier. | 2014-08-28 |
20140242191 | Prevention of Starch Degradation in Pulp, Paper or Board Making Processes - The invention relates to biocidal systems comprising zinc ions and an oxidizing or non-oxidizing biocide, their use, and methods for preventing or decreasing starch degradation in starch-containing process waters from pulp, paper or board production processes. | 2014-08-28 |
20140242192 | Clusterin Antisense Therapy for Treatment of Cancer - A method for providing antisense therapy which reduces the expression of clusterin to provide therapeutic benefits in the treatment of cancer comprising administering from 40 to 640 mg anti-clusterin antisense oligonucleotide to a patient in need of treatment for a cancer expressing clusterin is provided. The method may include administering chemotherapeutic agent or agents, radiotherapy, and/or hormone ablation therapy. The invention also encompasses pharmaceutical compositions formulated to provide a dosage of 40 to 640 mg, and use of antisense in formulating a medicament. | 2014-08-28 |
20140242193 | LITHIUM COMPOSITIONS - 2:1 cocrystals of amino acids and Li+ salts crystallize from hot water to afford water stable cationic networks based upon tetrahedral lithium cations: bilayered square grids, a lithium zeolitic metal-organic material (LiZMOM) and several lithium diamondoid metal-organic materials (LiDMOMs). The compositions may be used as a pharmaceutical for the treatment of suicidality and other disorders that require lithium to penetrate the blood brain barrier and exert therapeutic effects in the CNS. Advantageously, the novel cocrystal forms described herein may be used to lower the oral dose required to achieve therapeutic concentrations of lithium in the brain, thus reducing the peripheral toxicity and potentially broadening the therapeutic index in comparison to conventional lithium forms. | 2014-08-28 |
20140242194 | USE OF NITRITE SALTS IN TREATING TISSUE DAMAGE - Methods of treating a subject who has an tissue damage or who is at risk for tissue necrosis are disclosed. Also disclosed are methods of treating a subject who has an inflammatory disorder. The methods can include administering to the subject a pharmaceutical composition comprising inorganic nitrite or a pharmaceutically acceptable salt thereof, for a time and in an amount sufficient to reduce the tissue damage. The subject can be diagnosed as having a medical condition that results tissue damage, for example, diabetes, peripheral artery disease, cardiovascular disease, defective wound healing, arthritis, inflammatory bowel disease, ischemia, or a bacterial infection, e.g., Group A staphylococcal infection. The methods can include the step of monitoring the course of treatment. | 2014-08-28 |
20140242195 | AUTOMOTIVE SURFACE CONDITIONING SYSTEM - An automotive surface treatment system can include an aqueous antimicrobial composition which is formulated for use with automotive surfaces and has a volatile organic content no greater than 0.5% by weight. The aqueous antimicrobial composition includes an antimicrobial agent which is a combination of quaternary ammonium salts, a combination of surfactants which is at least one polyoxyalkylene surfactant, a fragrance, water, and at least one of a glycol solvent, a conditioner, a shine enhancer, a moisturizer, and UV protectant. The system also includes a dispense container which is adapted to retain the antimicrobial composition within the container and instructions attached to the dispenser. The instructions include directions to apply the antimicrobial composition to an automotive surface. | 2014-08-28 |
20140242196 | METHOD OF TREATING VENOMOUS BITES - The method of treating venomous bites, such as those from snakes and scorpions, involves treatment by the administration of a therapeutically effective amount of an aqueous extract of the fruit of | 2014-08-28 |
20140242197 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASES ON PLANTS - The present invention provides a method of treating root rot fungus, particularly | 2014-08-28 |