37th week of 2022 patent applcation highlights part 29 |
Patent application number | Title | Published |
20220290022 | OPTICAL DEVICE WITH ANTISTATIC COATING - Optical devices comprising at least one optical layer and at least one antistatic layer disposed on at least one surface of the optical layer wherein the antistatic layer comprises the reaction product of: (a) at least one polymerizable onium salt; and (b) at least one polymerizable, non-onium, silicone or perfluoropolyether moiety-containing monomer, oligomer, or polymer. | 2022-09-15 |
20220290023 | Composition for Temporarily-Hydrophobic and Oil-Absorbent Bioremediation Agent - A composition for temporarily-hydrophobic and oil-absorbent powder. The present invention cleans and neutralizes oily and toxic substances from items in water of bodies of water such as ocean floors or along the surface of bodies of water. The present invention initially repels water or water-based substances and then absorbs oil-based substances. The composition includes a quantity of quicklime, a quantity of oil, a quantity of earthworm enzymes, a quantity of water, a quantity of detergent, and a quantity of rubbing alcohol. The quantity of quicklime, the quantity of oil, the quantity of earthworm enzymes, the quantity of water, the quantity of detergent, and the quantity of rubbing alcohol are heterogeneously mixed into an absorbent slurry blend. | 2022-09-15 |
20220290024 | REFRIGERANT COMPOSITIONS COMPRISING HFC-32, HFC-125, AND CF3I - The present application relates to compositions comprising difluoromethane (R-32), pentafluoroethane (R-125), and trifluoroiodomethane (CF | 2022-09-15 |
20220290025 | RESIN COMPOSITION, HEAT STORAGE MATERIAL, AND ARTICLE - A resin composition contains: an acrylic resin polymerized from a monomer component containing a monomer represented by the following formula (1); and a heat storage inorganic material, | 2022-09-15 |
20220290026 | THERMALLY CONDUCTIVE NANOMATERIAL COATINGS ON FLEXIBLE FOAM OR FABRICS - A flexible cellular foam or fabric product is coated with a coating including highly thermally conductive nanomaterials. The highly thermally conductive nanomaterials may be carbon nanomaterials, metallic, or non-metallic solids. The carbon nanomaterials may include, but are not necessarily limited to, carbon nanotubes and graphene nanoplatelets. The highly thermally conductive nanomaterials may include but are not limited to nano-sized solids that may include graphite flakes, for example. When coated on a surface of flexible foam, the presence of nanomaterials may impart greater thermal effusivity, greater thermal conductivity, and/or a combination of these improvements. The flexible foam product may be polyurethane foam, latex foam, polyether polyurethane foam, viscoelastic foam, high resilient foam, polyester polyurethane foam, foamed polyethylene, foamed polypropylene, expanded polystyrene, foamed silicone, melamine foam, among others. | 2022-09-15 |
20220290027 | THERMALLY CONDUCTIVE ELASTOMER COMPOSITION AND THERMALLY CONDUCTIVE MOLDED ARTICLE - A thermally conductive elastomer composition of the present invention contains: 100 parts by mass of a styrene-based elastomer; from 610 to 750 parts by mass of a process oil formed of a petroleum-based hydrocarbon, the a process oil having a weight average molecular weight of not greater than 600; from 25 to 40 parts by mass of a solid nonionic surfactant having an HLB value of 2.0 or greater; from 260 to 640 parts by mass of aluminum hydroxide powder; and from 250 to 340 parts by mass of artificial graphite powder. | 2022-09-15 |
20220290028 | Thermally Conductive Polymer Compositions Containing Carbon Black - A composite polymer composition comprising partially crystallized carbon black. The composition exhibits superior thermal transfer properties in plastic formulations. The polymer precursor exhibits excellent rheology when compared to similar compositions comprising traditional carbon blacks. The composite polymers provide for higher loading of more thermally conductive carbon blacks in a variety of composite polymer compositions. | 2022-09-15 |
20220290029 | LECITHIN DRYING USING FATTY ACIDS - Aspects of the present invention provide methods of drying lecithin in a batch reaction, comprising the steps of obtaining a lecithin-containing material (derived from a crude refining stream) comprising 15-50% water, 10-30% acetone insoluble matter, and 10-20% free fatty acid; adding a fatty acid source (also derived from a crude refining stream) to the lecithin-containing material composition to obtain a lecithin/fatty acid reaction mixture; and blowing dry gas through the gum/fatty acid reaction mixture to obtain a resultant dried lecithin fatty acid blend having a water content of less than 2%. The resultant dried lecithin fatty acid blend may be used in asphalt or oil field applications. | 2022-09-15 |
20220290030 | DRILLING FLUIDS AND METHODS OF MAKING AND USING THEREOF - The present disclosure relates drilling fluids and methods of producing and using drilling fluids. The drilling fluid include includes an aqueous base fluid; a clay-based component; and a shale inhibitor comprising silica grafted with glutamate-glycol. The method of producing the drilling fluid includes reacting silica with glutamate and glycol thereby forming a shale inhibitor comprising silica grafted with glutamate-glycol; and mixing an aqueous base fluid, a clay-based component, and the shale inhibitor to produce a drilling fluid. The method of using the drilling fluid in drilling operations includes mixing an aqueous base fluid, a clay-based component, and a shale inhibitor comprising silica grafted with glutamate-glycol to produce a drilling fluid; and introducing the drilling fluid to a subsurface formation. | 2022-09-15 |
20220290031 | AQUEOUS FOAM COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF - Described herein are aqueous based foams for use in drilling operations. The foams can be used in below bubble point drilling operations to control the migration of reservoir gases (e.g., hydrogen sulfide) to the surface. | 2022-09-15 |
20220290032 | OIL-BASED DRILLING FLUID COMPOSITION, OIL-BASED DRILLING FLUID AND PREPARATION METHOD AND USE THEREOF - The present disclosure discloses an oil-based drilling fluid composition, including a base fluid and a treating agent, wherein the base fluid comprises a base oil and an inhibitor; the treating agent comprises an organic soil, a main emulsifier, an auxiliary emulsifier, a plugging agent, a weighting agent, a humectant, an alkaline regulator and a filtrate reducer; wherein 5-25 parts by weight of the inhibitor, 5-12 parts by weight of the organic soil, 1-6 parts by weight of the main emulsifier, 2-8 parts by weight of the auxiliary emulsifier, 3-18 parts by weight of the plugging agent, 5-30 parts by weight of the weighting agent, 2-6 parts by weight of the humectant, 2-7 parts by weight of the alkaline regulator and 2-10 parts by weight of the filtrate reducer are used, based on 100 parts by weight of base oil. | 2022-09-15 |
20220290033 | Polymer-Nanofiller Hydrogels - A polymer-nanofiller hydrogel including polymer hydrogel and nanofiller. The nanofiller is or includes nanosand. A method for forming the polymer-nanofiller hydrogel. A method of treating a wellbore in a subterranean formation, including applying a polymer-nanofiller hydrogel to the wellbore. | 2022-09-15 |
20220290034 | METHOD TO ATTENUATE ACID REACTIVITY DURING ACID STIMULATION OF CARBONATE RICH RESERVOIRS - Acidizing treatments for carbonate reservoir may include a surfactant comprising one or more of C | 2022-09-15 |
20220290035 | SAND CONSOLIDATION BY ENZYME MEDIATED CALCIUM CARBONATE PRECIPITATION - Methods for treating a formation may include introducing components of a treatment solution into a wellbore such that the treatment solution contacts the formation to be treated, where the treatment solution may include urea, urease, a calcium ion source, one or more polysaccharides, a casein protein, a protease, an ionic compound, and a sugar, where the formation may have an amount of sand production before treatment and may be in fluid contact with the wellbore, and where an amount of sand production after treatment may be less than the amount of sand production before treatment. Consolidated sand structure compositions may include previously unconsolidated sand interlinked by inter-particle cementitious bonds comprising deposited calcium carbonate crystals, where the consolidated sand has a structural strength and the consolidated sand structure is porous to permit fluid flow through the composition. | 2022-09-15 |
20220290036 | METHODS FOR MICROBIAL GAS PRODUCTION AND USE AS ISOTOPIC TRACER - Embodiments of the present disclosure relate to methods of natural gas production and carbon sequestration. In one embodiment, a method of generating biogas is disclosed, comprising delivering a feedstock downhole to a coal reservoir, generating biogas within the coal reservoir, and harvesting the biogas. In another embodiment, a method for tracing the migration of biogas in a coal reservoir is disclosed. The method comprises delivering a feedstock downhole to a coal reservoir via an injection well, generating biogas within the coal reservoir through microbial action, creating a biogas that is isotopically differentiable from a background gas that is native to the coal reservoir, harvesting the biogas at the injection well and one or more offset wells of the coal reservoir, analyzing the biogas and coal bed methane from the coal reservoir at the injection well and at one or more offset wells within the same coal reservoir, detecting the biogas at the offset wells using isotopic differentiation, and mapping the migration of the biogas from the injection well to the offset wells using the biogas as an isotopic tracer. | 2022-09-15 |
20220290037 | IONIC LIQUID ENHANCED SURFACTANT SOLUTION FOR SPONTANEOUS IMBIBITION IN FRACTURED CARBONATE RESERVOIRS - Provided is a composition that may include a mixture of an ionic liquid and a surfactant in an aqueous composition, where a carbonaceous hydrocarbon-bearing formation has a wettability value and comprises hydrocarbons, where there is an interfacial tension value between the aqueous composition and hydrocarbons present in the carbonaceous hydrocarbon-bearing formation, where the aqueous solution may be configured to modify the wettability value of the carbonaceous hydrocarbon-bearing formation from a first value to a second value that is more water-wet than the first value, and where the presence of the ionic liquid in the aqueous composition may not substantially impact the value for interfacial tension between the hydrocarbons in the carbonaceous hydrocarbon-bearing formation and the aqueous composition. Further provided is a method that may introduce the aqueous composition into a carbonaceous hydrocarbon-bearing formation. | 2022-09-15 |
20220290038 | RESIN COATED PROPPANTS WITH ANTIMICROBIAL ADDITIVES - Proppants are used in oil and gas extraction, particularly in fracking operations. The invention relates to resin coated proppants. The coatings on proppants have antimicrobial materials incorporated within these coatings. The antimicrobially active agents are incorporated in a concentration less than 70% by weight of the coatings or the active agent from these coatings can be released from these coatings in the environment of the proppants. | 2022-09-15 |
20220290039 | Viscoelastic-Surfactant Fracturing Fluids Having Oxidizer - A method and hydraulic fracturing fluid that is a viscoelastic surfactant (VES) fracturing fluid having a surfactant and an inorganic oxidizer salt for hydraulic fracturing of a geological formation. The VES fracturing fluid is provided through a wellbore into the geological formation to hydraulically fracture the geological formation to form hydraulic fractures in the geological formation. The method includes oxidizing organic material in the hydraulic fractures with the VES fracturing fluid. | 2022-09-15 |
20220290040 | USING ACIDIC BALLS FOR ACID STIMULATION IN CARBONATE RESERVOIRS - A method for acid treatment of a wellbore in a carbonate formation is provided. The method includes dropping spacer solids into the well to fill the wellbore to perforations in a casing, dropping acidic solids into the wellbore on the top of the spacer solids, allowing the acidic solids to dissolve on top of the spacer solids forming an acidic solution, and injecting water into the wellbore to force the acidic solution into the carbonate formation. | 2022-09-15 |
20220290041 | ELECTROCHROMIC COMPOUND, ELECTROCHROMIC COMPOSITION, AND ELECTROCHROMIC ELEMENT - An electrochromic compound has a structure represented by the following general formula (1): | 2022-09-15 |
20220290042 | ORGANIC ELECTROLUMINESCENT COMPOUNDS AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME - The present invention relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. The organic electroluminescent compound according to the present invention can be comprised in a light-emitting layer or an electron buffer layer, and is effective to produce an organic electroluminescent device having low driving voltage, excellent current and power efficiencies, and significantly improved operational lifespan. | 2022-09-15 |
20220290043 | LIGHT-SELECTIVE PARTICLES, RELATED METHODS AND RELATED APPLICATIONS - A method for preparing a light sensitive particle that uses at least one metal precursor material and at least one dopant precursor material mixed in solution absent a surfactant. Upon an optional adjustment of pH to about 3 to about 6, a light-sensitive particle comprising a metal-dopant material may be formed and separated from the solution. The light-sensitive particle may comprise a Q-dot particle. Also described are the particles themselves. | 2022-09-15 |
20220290044 | ROOM TEMPERATURE PHOSPHORESCENT METAL-FREE CARBON DOTS IN A CONTINUOUS SILICA NETWORK AND METHODS OF MAKING - Room temperature phosphorescent metal-free carbon dots (CDs) embedded in a continuous SiO | 2022-09-15 |
20220290045 | NARROW GREEN-EMITTING PHOSPHORS - Provided herein are phosphors of the formula: (A | 2022-09-15 |
20220290046 | SCINTILLATION COMPOUND INCLUDING A RARE EARTH ELEMENT AND A PROCESS OF FORMING THE SAME - A scintillation compound can include a rare earth element that is in a divalent (RE | 2022-09-15 |
20220290047 | PHOSPHOR, METHOD OF PRODUCING A PHOSPHOR, AND RADIATION EMITTING DEVICE - A phosphor may have the general formula EA | 2022-09-15 |
20220290048 | QUANTUM DOT DEVICE, FILM HAVING MULTILAYERED STRUCTURE, AND ELECTRONIC DEVICE - A quantum dot device, a method of manufacturing the same, a thin film having a multilayered structure, and an electronic device including the same. The quantum dot device includes a first electrode and a second electrode, a quantum dot layer disposed between the first electrode and the second electrode, and a hole transport layer disposed between the quantum dot layer and the first electrode, wherein the hole transport layer includes a first hole transport layer including a three-dimensional structure perovskite thin film and a second hole transport layer including a two-dimensional structure perovskite thin film. | 2022-09-15 |
20220290049 | COMPOSITION OF ETCHANT, METHOD FOR FORMING SEMICONDUCTOR DEVICE USING THE SAME, AND SEMICONDUCTOR DEVICE - The composition of an etchant is provided. The composition of the etchant includes about 0.1 to 13 wt % quaternary ammonium salt and about 45 to 90 wt % aprotic organic solvent. A method for forming a semiconductor device is provided. The method for forming the semiconductor device includes a step of removing a dummy gate by using an etchant with a composition that includes about 0.1 to 13 wt % quaternary ammonium salt and about 45 to 90 wt % aprotic organic solvent. A semiconductor device is provided. The semiconductor device includes a polycrystalline silicon component having an etched surface that was etched by an etchant with a composition that includes about 0.1 to 13 wt % quaternary ammonium salt and about 45 to 90 wt % aprotic organic solvent. The surface arithmetic mean height of the etched surface is 20 nm or less. | 2022-09-15 |
20220290050 | COMPOSITION, ITS USE AND A PROCESS FOR SELECTIVELY ETCHING SILICON-GERMANIUM MATERIAL - The invention relates to a composition for selectively etching a layer comprising a silicon germanium alloy (SiGe) in the presence of a silicon-containing layer, particularly a layer comprising a-Si, SiOx, SiON, SiN, or a combination thereof, the composition comprising: (a) an oxidizing agent, (b) an acid selected from an inorganic acid and an organic acid, 10 (c) an etchant comprising a source of fluoride ions, (d) a polyvinylpyrrolidone (PVP), and (e) water. | 2022-09-15 |
20220290051 | POLYUREA TREATMENT METHOD FOR METALLIC CORROSION PROTECTION - Methods for preventing, inhibiting, or reducing metal (e.g. mild steel) corrosion in aqueous media utilizing a water-soluble formulation having a polyurea pre-dissolved in a polar aprotic solvent are described. The polyurea contains reacted units of a diisocyanate and a diaminoalkane. The effectiveness of the methods is demonstrated by corrosion inhibition efficiency and corrosion rate of metallic substrates in aqueous acidic environments using the water-soluble formulation. | 2022-09-15 |
20220290052 | PYROLYSIS RESIDUE-DISCHARGE SYSTEM, PYROLYSIS REACTOR ASSEMBLY COMPRISING THE SAME AND CORRESPONDING METHOD - The present disclosure concerns a pyrolysis residue-discharge system fluid-tightly connectable to a pyrolysis reactor delimiting a fuel-containing cavity and having a discharge opening extending therethrough, the pyrolysis residue-discharge system comprising a residue discharge duct defining a residue discharge passageway having an inlet port and an outlet port; and a reactor-connecting end portion having a through opening, the reactor-connecting end portion being fluid-tightly connectable to the pyrolysis reactor to fluidly connect the through opening of the reactor-connecting end portion with the discharge opening of the pyrolysis reactor, the reactor-connecting end portion being fluid-tightly connectable to the residue discharge duct at the inlet port thereof to provide a fluid communication between the fuel-containing cavity of the pyrolysis reactor and the residue discharge passageway via the discharge opening. It also concerns a corresponding pyrolysis reactor assembly and a pyrolysis residue discharge method. | 2022-09-15 |
20220290053 | TWO STEP PROCESS FOR CHEMICALLY RECYCLING PLASTIC WASTE - A two-step process that includes a pyrolytic first step carried out in a mechanically or gravitationally impelled reactor and a catalytic fluid bed second step that upgrades the resulting vapor, for the conversion of waste plastics, polymers, and other waste materials to useful chemical and fuel products such as paraffins, olefins, and aromatics such as BTX is described. | 2022-09-15 |
20220290054 | METHOD OF ESTIMATING SURFACE TENSION OF COAL INERT MATERIAL, METHOD OF ESTIMATING SURFACE TENSION OF COAL, AND METHOD OF PRODUCING COKE - A method of estimating a surface tension of coal inert material includes determining in advance a first relational expression representing a relationship between a surface tension of coal inert material and a physical property value representing a coal rank; and measuring the physical property value representing the coal rank of a coal for which the surface tension of coal inert material is to be estimated, and calculating the surface tension of the coal inert material by using the measured physical property value representing the coal rank and the first relational expression. | 2022-09-15 |
20220290055 | SYNERGISTIC EFFECTS AMONG MERCAPTAN SCAVENGERS - A combination of at least one basic compound, such as potassium hydroxide, together with at least one aldehyde donor can synergistically scavenge mercaptans from organic fluids, such as hydrocarbons, where “synergistically effective” is defined as the amount of mercaptans scavenged is greater as compared with a combination where either the basic compound or the reaction product is absent, used in the same total amount. | 2022-09-15 |
20220290056 | METHOD FOR REMOVING SULFUR FROM LIQUID FUEL - Carbon nanofiber doped alumina (Al—CNF) supported MoCo catalysts in hydrodesulfurization (HDS), and/or boron doping, e.g., up to 5 wt % of total catalyst weight, can improve catalytic efficiency. Al—CNF-supported MoCo catalysts, (Al—CNF-MoCo), can reduce the sulfur concentration in fuel, esp. liquid fuel, to below the required limit in a 6 h reaction time. Thus, Al—CNF—MoCo has a higher catalytic activity than Al—MoCo, which may be explained by higher mesoporous surface area and better dispersion of MoCo metals on the AlCNF support relative to alumina support. The BET surface area of Al—MoCo may be 75% less than Al—CNF—MoCo, e.g., 166 vs. 200 m | 2022-09-15 |
20220290057 | Metal-Organic Framework Catalysts and Their Use Thereof in Catalytic Cracking - A hydrocarbon feed stream, particularly one comprising heavier hydrocarbons, may be converted to valuable products such as motor gasoline and/or lubricating oil by employing one or more MOF catalysts, which may be prepared from a precursor metal-organic framework (MOF). A MOF catalyst may be prepared by exchanging one or more organic linking ligands of the precursor MOF for an organic linking ligand having a different acidity and/or electron-withdrawing properties, which, in turn, may affect catalytic activity. | 2022-09-15 |
20220290058 | INTEGRATED PROCESS FOR THE PRODUCTION OF ISONONANOL AND STABLE / LUBRICATING GASOLINE AND DIESEL BLENDING COMPONENTS - In accordance with one or more embodiments of the present disclosure, a method for producing epoxide gasoline blending components includes cracking, in a steam cracker, a hydrocarbon feed to form a first ethylene stream, a first propylene stream, and a C | 2022-09-15 |
20220290059 | ENVIRONMENT-FRIENDLY MARINE FUEL - For the shipping industry, these fuels provide solutions to long outstanding technical problems that heretofore hindered supply of low sulfur marine fuels in quantities needed to meet worldwide sulfur reduction goals. Marine shipping use of high sulfur bunker oils is reported as largest source of world-wide transportation SOx emissions. When ships on the open seas burn cheap low grade heavy bunker oils high in sulfur, nitrogen and metals, the SOx, NOx, and metal oxides go to the environment. This invention converts essentially all of each barrel of crude feed to a single ultraclean fuel versus conventional refining where crude feed is cut into many pieces, and each piece is sent down a separate market path meeting various different product specifications. When in port, ships can use these fuels to generate and sell electricity to land based electrical grids to offset fuel cost in an environment-friendly manner. | 2022-09-15 |
20220290060 | ENVIRONMENT-FRIENDLY MARINE FUEL - For the shipping industry, these fuels provide solutions to long outstanding technical problems that heretofore hindered supply of low sulfur marine fuels in quantities needed to meet worldwide sulfur reduction goals. Marine shipping use of high sulfur bunker oils is reported as largest source of worldwide transportation SOx emissions. When ships on the open seas burn cheap low grade heavy bunker oils high in sulfur, nitrogen and metals, the SOx, NOx, and metal oxides go to the environment. This invention converts essentially all of each barrel of crude feed to a single ultraclean fuel versus conventional refining where crude feed is cut into many pieces, and each piece is sent down a separate market path meeting various different product specifications. When in port, ships can use these fuels to generate and sell electricity to land based electrical grids to offset fuel cost in an environment-friendly manner. | 2022-09-15 |
20220290061 | ENVIRONMENT-FRIENDLY MARINE FUEL - For the shipping industry, these fuels provide solutions to long outstanding technical problems that heretofore hindered supply of low sulfur marine fuels in quantities needed to meet worldwide sulfur reduction goals. Marine shipping use of high sulfur bunker oils is reported as largest source of worldwide transportation SOx emissions. When ships on the open seas burn cheap low grade heavy bunker oils high in sulfur, nitrogen and metals, the SOx, NOx, and metal oxides go to the environment. This invention converts essentially all of each barrel of crude feed to a single ultraclean fuel versus conventional refining where crude feed is cut into many pieces, and each piece is sent down a separate market path meeting various different product specifications. When in port, ships can use these fuels to generate and sell electricity to land based electrical grids to offset fuel cost in an environment-friendly manner. | 2022-09-15 |
20220290062 | ENVIRONMENT-FRIENDLY MARINE FUEL - For the shipping industry, these fuels provide solutions to long outstanding technical problems that heretofore hindered supply of low sulfur marine fuels in quantities needed to meet worldwide sulfur reduction goals. Marine shipping use of high sulfur bunker oils is reported as largest source of world-wide transportation SOx emissions. When ships on the open seas burn cheap low grade heavy bunker oils high in sulfur, nitrogen and metals, the SOx, NOx, and metal oxides go to the environment. This invention converts essentially all of each barrel of crude feed to a single ultraclean fuel versus conventional refining where crude feed is cut into many pieces, and each piece is sent down a separate market path meeting various different product specifications. When in port, ships can use these fuels to generate and sell electricity to land based electrical grids to offset fuel cost in an environment-friendly manner. | 2022-09-15 |
20220290063 | A GASIFICATION APPARATUS AND METHOD - A gasification apparatus has a primary chamber with a floor comprising a hearth and feedstock augers, for gasification of feedstock. There is a mixing chamber for receiving through an opening synthetic gases from the primary chamber and comprising an air inlet fan for adding oxygen for ignition. There is also a secondary chamber linked with the mixing chamber to deliver heat from combustion of gases from the mixing chamber to the hearth. An outlet valve delivers gases from the secondary chamber through a heat exchanger and to an induce draft fan. A controller dynamically controls flow of gases in the chambers according to sensed pressures and temperatures in said chambers. | 2022-09-15 |
20220290064 | Supercritical Water Gasification Process - The process described herein converts biomass directly into a combination of hydrogen, methane and carbon dioxide. A portion of the gases are collected at pressures above the thermodynamic critical pressure for water, which is 3200 psi (pounds per square inch). Typical operating pressure at the point where the first portion of gas collected can range from 3200 psi to 6000 psi. Upon cooling, most of the CO | 2022-09-15 |
20220290065 | COMBINATION OF ANAEROBIC TREATMENT OF CARBONACEOUS MATERIAL WITH HYDROTHERMAL GASIFICATION TO MAXIMIZE VALUE ADDED PRODUCT RECOVERY - A method for treating carbonaceous material, the method includes a) providing a carbonaceous material CM, b) subjecting the carbonaceous material CM to hydrothermal gasification in a HTG reactor, thereby producing: an inorganic solid residue, a first gaseous fraction G1 comprising CH | 2022-09-15 |
20220290066 | LOW PROFILE LUBRICANTS FOR DATA STORAGE DEVICES - Low-profile thermally stable lubricants for data storage devices are provided based on multi-dentate molecular designs. One such lubricant comprises perfluoroalkyl ether segments, a divalent linking segment, and anchoring functional groups attachable to, or engageable with, a protective overcoat of a magnetic recording medium. The lubricants can be used in conjunction with a magnetic recording medium and/or a magnetic data storage system. | 2022-09-15 |
20220290067 | FRICTION AND WEAR REDUCTION ADDITIVES - The present invention relates to additives for reducing friction and wear in lubricants. In particular, the present invention relates to novel salts and their use in lubricating oil compositions for reducing friction and wear. In particular, the present invention relates to one or more ionic liquids, wherein the one or more ionic liquids comprise one or more cations and one or more Group 6 metal mononuclear metallate anions. | 2022-09-15 |
20220290068 | GREASE COMPOSITION INCLUDING COPPER SULFIDE FOR CONSTANT VELOCITY JOINTS - A grease composition is intended primarily for use in constant velocity joins (CV joints), especially ball joints and/or tripod joints, which are used in the drivelines of motor vehicles. The grease composition for use in constant velocity joints comprises at least one base oil, and least one thickener, at least one copper sulfide in an amount of approximately 0.01 wt-% up to approximately 1.5 wt-% of the grease composition, molybdenum disulfide and/or at least one phosphor-free organic molybdenum complex in an amount of approximately 0.1 wt-% up to approximately 5.0 wt-% of the grease composition. Further, a constant velocity joint comprises the grease composition. | 2022-09-15 |
20220290069 | REMEDIATED OILS - Remediating hemp oil includes controlling heat and oxygenation levels to reduce the relative weight percentage of THC while mitigating the conversion of other cannabinoids to other compounds. The method may include bubbling air, oxygen, or another oxygen-containing gas into a reactor while maintaining the temperature of the hemp oil. | 2022-09-15 |
20220290070 | DETERGENT COMPOSITIONS FOR CLEANING IN THE COSMETIC AND PHARMACEUTICAL INDUSTRY - The invention relates to the use of a detergent composition for removing hydrophobic residues and pigments on manufacturing or packaging devices or any other hardware used for manufacturing or packaging cosmetic or pharmaceutical compositions, said detergent composition including: a non-ionic surfactant selected from among the alkoxylated fatty alcohols; a non-aromatic co-surfactant selected from among the amine oxides, alkyl sulfates and alkyl sulfonates; and an organic alkaline agent selected from among the amino alcohols, excluding monoethanolamine, the non-aromatic co-surfactant being contained in the detergent composition in an amount of from 1 to 15 wt % in relation to the total weight of the composition. | 2022-09-15 |
20220290071 | MULTIPURPOSE ACIDIC COMPOSITIONS AND METHODS OF USE - Multipurpose acidic compositions for cleaning and/or sanitizing are provided. The acidic compositions are liquids that remove polymerized soils, hard water deposit (e.g., calcium carbonate), soap scum, rust and other stains (e.g., coffee and tea), including assisting in general cleaning of difficult soils, such as fats, oils, cosmetics, and other difficult soils. The acidic compositions can include at least one organic acid and a solvent or solvent system, and if desired, can be PPE free compositions. Methods for using the acidic compositions as pre-treatments, soaks and/or application in machine and manual warewash are also provided. Methods for using the acidic compositions for removing polymerized oils, carbonized soils, fats, oils, stains (e.g., coffee and tea), hard water scale/deposits, and cosmetics are also provided. | 2022-09-15 |
20220290072 | CONTACT LENS TREATING SOLUTION - A contact lens treating solution includes (a) about 0.005 to about 2 wt. %, based on the total weight of the contact lens treating solution, of hyaluronic acid or a salt thereof; (b) about 0.01 to about 1 wt. %, based on the total weight of the contact lens treating solution, of erythritol; (c) one or more nonionic surfactants; (d) sodium chloride, potassium chloride or any combination thereof; and (e) one or more buffers. | 2022-09-15 |
20220290073 | PRESERVATIVE-FREE CONTACT LENS TREATING SOLUTION - A preservative-free contact lens treating solution includes (a) about 0.005 to about 2 wt. %, based on the total weight of the preservative-free contact lens treating solution, of hyaluronic acid or a salt thereof; (b) about 0.01 to about 1 wt. %, based on the total weight of the preservative-free contact lens treating solution, of erythritol; (c) one or more nonionic surfactants; (d) sodium chloride, potassium chloride or any combination thereof; and (e) one or more buffers. | 2022-09-15 |
20220290074 | DETERGENT COMPOSITION FOR DISSOLVING A MINERAL DEPOSIT - Compositions for rapidly dissolving mineral deposits on the surface of an apparatus, particularly a food or beverage-handling clean-in-place (CIP) apparatus, and methods of using the same are provided. In particular, the compositions are effective in removing magnesium phosphate deposits and comprise at least two mineral acids, with one of the mineral acids being nitric acid, and at least one nonionic surfactant. | 2022-09-15 |
20220290075 | FABRIC SOFTENER - A fabric softener composition comprising: a. 1 to 20 wt. % ionic compound of general formula I: (I) b. 0.1 to 30 wt. % perfume; and c. Water. | 2022-09-15 |
20220290076 | A DEPOSITION AID POLYMER FOR LAUNDRY - A deposition aid polymer for laundry is provided, comprising >50 to 99 wt % of structural units of formula (I) | 2022-09-15 |
20220290077 | FABRIC CARE COMPOSITION - A fabric care composition is provided, comprising: a fabric care benefit agent; and a deposition aid polymer is provided, comprising >50 to 99 wt % of structural units of formula (I) | 2022-09-15 |
20220290078 | COMPOSITION, AND METHOD FOR CLEANING ADHESIVE POLYMER - Provided is a composition which has an excellent affinity with the surface of an adhesive agent and can achieve a high etching rate. The composition according to one embodiment comprises: a quaternary alkylammonium fluoride or a hydrate of a quaternary alkylammonium fluoride; and, as an aprotic solvent, (A) an N-substituted amide compound having no active hydrogen on a nitrogen atom, and (B) a dipropylene glycol dimethyl ether, wherein (B) the dipropylene glycol dimethyl ether has the percentage of a structural isomer represented by formula (1) of at least 50 mass % with respect to the total amount of (B) the dipropylene glycol dimethyl ether. | 2022-09-15 |
20220290079 | Pichia kudriavzevii and multifunctional complex microbial inoculant and use thereof - The present disclosure discloses a | 2022-09-15 |
20220290080 | CELL CULTURE ASSEMBLIES AND METHODS OF USING THE SAME - A cell culture assembly includes a film defining a plurality of wells extending into the film, where each well of the plurality of wells defines a perimeter extending around the well, the plurality of wells defines an outer perimeter extending around the plurality of wells and extending between the perimeters of adjacent wells of the plurality of wells, and the outer perimeter extending around the plurality of wells defines a wave shape, and a sidewall member coupled to the film, where at least a portion of the sidewall member is oriented transverse to the film, the sidewall member including an engagement portion defining a wave shape that is complementary with the outer perimeter of the plurality of wells. | 2022-09-15 |
20220290081 | ORGAN-ON-A-CHIP AND A FABRICATION METHOD THEREOF - The present disclosure relates to an organ-on-a-chip, and according to the present disclosure, the organ-on-a-chip includes a first layer having a first microfluidic channel to culture a first organ cell, a second layer having a second microfluidic channel, a third layer having a third microfluidic channel to culture a second organ cell, a first membrane to spatially separate the first microfluidic channel from the second microfluidic channel, and a second membrane to spatially separate the second microfluidic channel from the third microfluidic channel, thereby measuring the rate of absorption of a test drug into the first organ cell and the second organ cell at the same time. | 2022-09-15 |
20220290082 | METHOD FOR PRODUCING EXOSOME - The present invention provides a method for producing an exosome, comprising a step of applying a cell to a cell culture module to culture the cell and a step of producing an exosome by the cell, wherein the cell culture module is provided with a polymer porous film and a casing having at least two culture medium in-flow/out-flow ports and having the polymer porous film placed therein. | 2022-09-15 |
20220290083 | CELL CULTURING METHOD USING SMALL-PIECE POROUS MEMBRANE - The purpose of the present invention is to provide a cell culturing method using a small-piece polymer porous membrane. The present invention provides a cell culturing method which does not require stirring and comprises applying cells to a small-piece polymer porous membrane having an area of a surface layer A or B of at most 4 mm2, and culturing the cells. The small-piece polymer porous membrane has a characteristic three-dimensional structure, and a medium can be more easily supplied and recovered by utilizing the property that small-piece polymer porous membranes are dispersed in a cell culture solution and/or small-piece polymer porous membranes are accumulated in multiple layers, and thus the small-piece polymer porous membranes are dispersed and/or laminated on a bottom part of a cell culture vessel. Consequently, long-term culture and mass culture are achieved, and thus the stable long-term production of exosomes is possible. | 2022-09-15 |
20220290084 | Multilayer Culture Vessel - A multilayer culture vessel, comprising a culture vessel part and a reservoir part attached to the culture vessel part, wherein the culture vessel part comprises at least two culture trays that are stacked; the reservoir part comprises a surrounding wall defining an internal space and a port communicating with the internal space; the surrounding wall comprises a first surrounding wall part provided with the port and a second surrounding wall part facing the first surrounding wall part; the culture vessel part has openings communicating individual culture trays of the at least two culture trays with the internal space of the reservoir part; and the openings of the culture vessel part extend toward a first abutting portion that the first surrounding wall part abuts on the culture vessel part from a second abutting portion that the second surrounding wall part abuts on the culture vessel part. | 2022-09-15 |
20220290085 | CELL-SENSORY BIOSCAFFOLDS, FABRICATION METHODS AND APPLICATIONS OF SAME - A cell sensor and methods of using the cell sensor for differentiating types of cells. The cell sensor includes a sensing member having bioscaffolds comprising nanofibers/nanowires of titanate grown on a titanium sheet. The method includes preparing a cell sensor comprising a sensing member having bioscaffolds comprising nanofibers/nanowires of titanate grown on a titanium sheet; incubating the bioscaffolds with cells in an aqueous solution at an incubation temperature for a period of incubation time, wherein the cells in the aqueous solution include at least one of cancer cells, normal cells, stem cells, and neuron cells; and measuring electrical characteristics of the bioscaffolds to determine the types of the cells based on the measured electrical characteristics. | 2022-09-15 |
20220290086 | METHODS AND SYSTEMS FOR CELL CULTURE - Provided herein are methods for the preparation of perfusable scaffolds for cell culture. These methods can comprise providing a bioink composition and a fugitive ink composition; chaotic printing the bioink composition and the fugitive ink composition to generate a microstructured precursor comprising a plurality of lamellar structures formed from the bioink composition; curing the bioink composition to form a cured scaffold precursor; and removing the fugitive ink from the cured scaffold precursor, thereby forming the perfusable scaffold. Also provided are scaffolds prepared by these methods as well as modular bioreactors incorporating these scaffolds. | 2022-09-15 |
20220290087 | CELL CO-CULTURE SYSTEM AND METHOD - The present invention relates to a method and an apparatus for in vitro three-dimensional cell co-culture, wherein said method comprises a step of seeding a plurality of cells of a first cell type on a first magnetic prismatic porous scaffold and a plurality of cells of a second cell type on a second magnetic prismatic porous scaffold, while keeping the first and second scaffolds physically separate, and a step of moving the first and second scaffolds towards each other under the action of a magnetic field generated by a magnetic field generator until contact occurs on at least one surface. | 2022-09-15 |
20220290088 | PREPARATION DEVICE AND METHOD FOR PREPARING A CELL SUSPENSION FOR AN ANALYTICAL METHOD - A preparation system for preparing a cell suspension having a carrier on which a reactor housing and a magnet system are accommodated, wherein, in the reactor housing, a reaction channel is formed, which extends between an inlet opening arranged centrally on an upper side of the reactor housing and an outlet opening arranged on the outside of the reactor housing and which is bounded by a channel wall, the magnet system being received on the carrier so as to be relatively movable between a first functional position, to bear with a pole face against the channel wall of the reaction channel and a second functional position to assume with the pole face a predetermined distance relative to the channel wall, and having a reactor housing drive for initiating a rotational movement on the reactor housing. | 2022-09-15 |
20220290089 | DISPOSABLE DEVICE FOR VENTING A SEALED CONTAINER AND ALIQUOTING THEREFROM - A multi-port disposable device that can both vent a sealed culture vessel and draw a sample therefrom into a collection vessel. The multi-port disposable device has a first port configured to receive the top portion of a culture vessel and attach thereto. The multi-port disposable device has a second port configured to receive a sample collection vessel. The multi-port disposable device has first and second needles. The first needle has a cannula configured to penetrate a septum or cap of the culture vessel. Optionally, the cannula terminates in a layer of foam that carries a microbial agent such that any vapor that is transmitted from the culture vessel through the cannula when venting the sealed culture vessel is absorbed by the foam. Optionally, the ports of the disposable device are configured as sleeves. The sleeve of the first port receives a portion of the culture vessel and the sleeve of the second port receives the collection vessel. The second needle has a cannula that penetrates both the septum or cap of the culture vessel and the septum or cap of the collection vessel, when the culture vessel and the collection vessel are brought into the device, thereby providing for fluid communication between the culture vessel and the collection vessel. The second cannula provides the flow pathway for delivering sample from the culture vessel to the collection vessel. | 2022-09-15 |
20220290090 | AUTOMATED CONTROL AND PREDICTION FOR A FERMENTATION SYSTEM - The present disclosure provides methods and systems for foam control. A method of foam control for a fermentation system comprises: obtaining image data from an imaging device located at the fermentation system; and processing said sensor data using a trained machine learning algorithm to generate an output that indicates presence of foam or level of foaming. | 2022-09-15 |
20220290091 | PROCESS CONTROL SYSTEMS FOR AUTOMATED CELL ENGINEERING SYSTEMS - Systems and methods for process control of automated cell engineering systems are provided. Automated cell engineering systems provide automated cell processing functionality. Automated process control systems provide control, interconnectivity, monitoring, data archival, software updating, and other oversight functions for automated cell engineering systems. Further, central control process systems provide control, monitoring, data archival, software updating, and other oversight functions for automated process control systems. | 2022-09-15 |
20220290092 | METHOD AND APPARATUS FOR PROCESSING TISSUE SAMPLES - A system, methods, and apparatus are described to collect and prepare single cells, nuclei, subcellular components, and biomolecules from specimens including tissues and in some embodiments use the single cells to form organoids or microtissues. The system can perform enzymatic and/or physical disruption of the tissue to dissociate it into single-cells and then use a hanging droplet method to form organoids or microtissues. | 2022-09-15 |
20220290093 | Method for Proliferation of Cells Within a Bioreactor Using a Disposable Pumphead and Filter Assembly - A method for promoting biological activity uses a filter system to increase cell production of a fed batch bioreactor. The filter system cycles bioreactor fluid through a hollow fiber tangential flow filter which separates metabolic wastes (as well as proteins) from cells produced in bioreactor and returned to fed batch bioreactor, improving cell production in the fed batch bioreactor. The filter system includes a disposable pump and filter, and a reusable control system. The pump is a low shear gamma stable pump gently cycling bioreactor fluid through the filter with minimal damage to the cells produced in the bioreactor. The pumphead and hollow fiber tangential flow filter are disposable. The pump motor is part of the control system and is reusable. The pumphead and filter are provided as an assembled and pre-sterilized unit allowing simple and quick attachment to the fed batch bioreactor, and simple and quick disposal. | 2022-09-15 |
20220290094 | ASEPTIC TISSUE PROCESSING METHOD, KIT AND DEVICE - The present invention concerns a single use aseptic kit comprising: a disaggregation module for receipt and processing of material comprising solid mammalian tissue; and a stabilisation module for storing disaggregated product material, wherein each of said modules comprises one or more flexible containers connected by one or more conduits adapted to enable flow of the tissue material there between; and wherein each of said modules comprises one or more ports to permit aseptic input of media and/or reagents into the one or more flexible containers. The invention further relates to an automated device for semi-automated aseptic disaggregation and/or enrichment and/or stabilisation of cells or cell aggregates from mammalian solid tissue comprising a programmable processor and the single use aseptic kit. The invention further relates to a semi-automatic aseptic tissue processing method. | 2022-09-15 |
20220290095 | Bifidobacterium breve CCFM1025, Food Fermented Thereby and Application Thereof - CCFM1025, foods fermented thereby and an application thereof in the preparation of an anti-depression drug, an anti-inflammatory bowel disease drug, an anti-obesity drug, health products and functional foods. | 2022-09-15 |
20220290096 | METHOD FOR PRODUCING BIOLOGICAL TISSUE - Method for producing biological tissue, in particular for medical treatment and/or pharmacological examinations, wherein a support for cell tissue is provided, wherein a printing medium containing living cells is provided, wherein the printing medium is printed onto the support through a printing screen and/or a printing stencil, and wherein the printed cells develop into tissue by the printing and/or after the printing. | 2022-09-15 |
20220290097 | Poultry Egg-Based Culture Medium - Disclosed is a poultry egg-based culture medium relating to the field of biotechnology, in particular a culture medium that can be used for cultivating mammalian cells, the culture medium containing a poultry egg content and a diluent. Also related is preparation and use of the culture medium, and a method of using the culture medium for cultivating mammalian cells. | 2022-09-15 |
20220290098 | METHOD FOR DIAGNOSING AND TREATING ATHEROSCLEROSIS BY USING NANOVESICLE TARGETING SITE OF CHANGE IN BLOOD FLOW - The present invention relates to a method for diagnosing and treating atherosclerosis by using nanovesicle targeting a site of change in blood flow, and more specifically, the present invention provides a stem cell-derived nanovesicle, which is an anti-atherosclerosis diagnosis and treatment platform using a peptide capable of targeting a disturbed blood flow, wherein the nanovesicle provides strong anti-inflammatory and pre-endothelial recovery effects similar to that of a mesenchymal stem cell, and thus it can be used as a new diagnosis and treatment agent capable of preventing the onset of atherosclerosis. | 2022-09-15 |
20220290099 | INDUCED PLURIPOTENT CELL-DERIVED OLIGODENDROCYTE PROGENITOR CELLS FOR THE TREATMENT OF MYELIN DISORDERS - The present disclosure relates to a preparation of CD140a/PDGFRα positive cells that comprises oligodendrocyte progenitor cells co-expressing OLIG2 and CD140a/PDGFRα. The preparation of cells is derived from pluripotent cells that were derived from skin cells, fibroblasts, umbilical cord blood, peripheral blood, bone marrow, or other somatic cells. The cell preparation has an in vivo myelination efficiency that is equal to or greater than the in vivo myelination efficiency of a preparation of A2B5+/PSA-NCAM-sorted fetal human tissue derived oligodendrocyte progenitor cells. Methods of making, isolating and using the disclosed cell preparation are also described. | 2022-09-15 |
20220290100 | NEURAL ORGANOID COMPOSITION AND METHODS OF USE - The present invention features a neural organoid that recapitulates in vitro most characteristics of the brain (e.g., human), and methods of using this neural organoid to study disease and to identify therapeutic agents for the treatment of neurological diseases and disorders. | 2022-09-15 |
20220290101 | EX VIVO GAMMA DELTA T CELL POPULATIONS - The invention relates to ex vivo methods of modulating Vδ1 T cells using anti-Vδ1 antibodies or fragments thereof. | 2022-09-15 |
20220290102 | COMPOSITION FOR CULTURING REGULATORY T CELLS AND USE THEREOF - The present invention relates to a method for effectively proliferating regulatory T cells, by which, particularly, in the presence of a fusion protein dimer comprising IL-2 protein or a variant thereof and CD80 protein or a fragment thereof, CD4+, CD25+, and CD127− T cells can be effectively proliferated. In particular, when combined with a predetermined cell culture medium, regulatory T cells such as CD4+, CD25+, and CD127− can be effectively and specifically proliferated. In addition, when the method is used, it has been confirmed that the survival rate of regulatory T cells is remarkably increased as compared to a conventionally used culture method using IL-2, and a significant increase in the yield of Foxp3+ regulatory T cells has been confirmed. Thus, such a proliferation method can be used in the field of cell therapeutic agents using regulatory ‘I’ cells. | 2022-09-15 |
20220290103 | METHODS AND COMPOSITIONS USING AUXOTROPHIC REGULATABLE CELLS - The present disclosure provides compositions and methods for producing and using modified auxotrophic host cells for improved therapy involving administration of an auxotrophic factor. | 2022-09-15 |
20220290104 | METHODS FOR GENERATING HEMATOPOIETIC STEM CELLS - In some aspects and embodiments, the invention provides methods for making hematopoietic stem cells, including for HSCT. The method comprises providing a cell population comprising hemogenic endothelial (HE) or endothelial cells, and increasing activity or expression of DNA (cytosine-5-)-methyltransferase 3 beta (Dnmt3b) and/or GTPase IMAP Family Member 6 (Gimap6) in the HE and/or endothelial cells under conditions sufficient for stimulating formation of HSCs. | 2022-09-15 |
20220290105 | MESENCHYMAL STEM CELLS WITH ENHANCED THERAPEUTIC PROPERTIES - Mesenchymal stem cells with enhanced therapeutic properties. The present invention refers to a method for obtaining mesenchymal stem cells (MSCs) with enhanced immunosuppression, chondroprotection and chondrodifferentiation properties, and enhanced capability to promote the proliferation of chondrocytes. The method comprises contacting the MSCs; culturing MSC in a induction media supplemented with 0.01 to 100 μg/ml of an ATP-synthase inhibitor; and removing the induction media to obtain MSC with enhanced activity. Moreover, the present invention also refers to the MSCs themselves and to their use for cell therapy purposes, preferably for treating autoimmune and/or osteoarticular diseases. | 2022-09-15 |
20220290106 | Method for Promoting Cell Proliferation, and Method for Preparing Cell Cluster - Provided is a method that is able to simply promote cell proliferation. | 2022-09-15 |
20220290107 | METHOD FOR PRODUCING CULTURED TISSUE, AND PREPARATION FOR EXTERNAL APPLICATION - An object of the present invention is to provide a new means for suppressing inhibition of proliferation of keratinocytes even when the keratinocytes start to come into contact with each other. The present invention solves the above problem by culturing keratinocytes in contact with a common medium with fibroblasts treated with a composition containing a specific compound. | 2022-09-15 |
20220290108 | OPTIMIZED METHOD FOR LARGE SCALE PRODUCTION OF PARVOVIRUS H-1 IN AN ESSENTIALLY SERUM-FREE MEDIUM - Described is an optimized process for parvovirus production including an essentially serum-free medium which is suitable to increase parvovirus production compared to a standard medium, preferably for H-1PV production. | 2022-09-15 |
20220290109 | A Recombinant of Hydrogenophilus Bacterium Producing Lactic Acid - When lactate dehydrogenase gene and/or malate/lactate dehydrogenase gene is/are introduced into a | 2022-09-15 |
20220290110 | PEROXIDASE ACTIVITY TOWARDS 10-ACETYL-3,7-DIHYDROXYPHENOXAZINE - The present invention provides engineered peroxidase enzymes, polypeptides having peroxidase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing peroxidase enzymes are also provided. The present invention further provides compositions comprising the peroxidase enzymes and methods of using the engineered peroxidase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds. | 2022-09-15 |
20220290111 | NUCLEIC ACIDS, PROTEINS AND PROCESSES FOR PRODUCING AMIDES - The invention provides polynucleotides and nucleic acid molecules encoding piperine synthases and proteins and enzyme functional for converting piperoyl-CoA and piperidine to piperine. The invention also provides a method of producing an amide from an acyl-CoA and an amine, and to a method of producing an amide from a carboxylic acid and an amine. | 2022-09-15 |
20220290112 | VARIANT REVERSE TRANSCRIPTASE EXHIBITING EXCELLENT STABILITY - An object is to provide a novel variant reverse transcriptase with excellent stability. The present invention provides a variant reverse transcriptase consisting of an amino acid sequence having at least 90% identity with an amino acid sequence represented by SEQ ID NO: 1, wherein a cysteine residue at a position corresponding to at least one position selected from the group consisting of 90, 157, 236, 262, 310, 409, 495, and 635 is modified. In a specific embodiment, the modification of the cysteine residue is substitution with at least one non-polar amino acid residue selected from the group consisting of alanine, glycine, valine, leucine, and isoleucine. | 2022-09-15 |
20220290113 | PROGRAMMABLE DNA BASE EDITING BY NME2CAS9-DEAMINASE FUSION PROTEINS - The present invention is related to the field of gene editing. In particular, the gene editing is directed toward single nucleotide base editing. For example, such single nucleotide base editing results in a conversion of a OG base pair to a T*A base pair. The high accuracy and precision of the presently disclosed single nucleotide base gene editor is accomplished by an NmeCas9 nuclease that is fused to a nucleotide deaminase protein. The compact nature of the NmeCas9 coupled with a larger number of compatible protospacer adjacent motifs provide the Cas9 fusion constructs contemplated herein to have a gene editing window that can edit sites that are not targetable by other conventional SpyCas9 base editor platforms. | 2022-09-15 |
20220290114 | ANTIMICROBIAL ENDOLYSIN POLYPEPTIDES, COMPOSITIONS AND FORMULATIONS - The present invention relates to novel endolysin polypeptides or fragments thereof which possess antimicrobial activity, preferably antibacterial activity against | 2022-09-15 |
20220290115 | HIGH EFFICIENCY BASE EDITORS COMPRISING GAM - Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins comprise a Gam protein, a napDNAbp, and a cytidine deaminase. In some embodiments, the fusion proteins further comprise a UGI domain. In some embodiments, methods for targeted nucleic acid editing are provided. In some embodiments, reagents and kits for the generation of targeted nucleic acid editing proteins, e.g., fusion proteins of a Gam protein, a cytidine deaminase and nucleic acid editing proteins or domains, are provided. | 2022-09-15 |
20220290116 | CYSTATHIONINE BETA-SYNTHASE ENZYME THERAPY FOR TREATMENT OF ELEVATED HOMOCYSTEINE LEVELS - The present disclosure provides methods for treating homocystinuria or elevated homocysteine levels in subjects, including methods of improving cognitive function and ameliorating skeletal fragility, and methods of stratifying patient populations to determine disease progression or severity and/or to determine treatment regimens. In some embodiments, the methods of improving cognitive function in a subject having elevated total plasma homocysteine (tHcy) levels further comprise providing a cognitive or behavioral intervention. | 2022-09-15 |
20220290117 | ENZYMATIC PRODUCTION OF HEXOSES - Disclosed herein are methods of producing hexoses from saccharides by enzymatic processes. The methods utilize fructose 6-phosphate and at least one enzymatic step to convert it to a hexose. | 2022-09-15 |
20220290118 | SYSTEMS FOR STRETCHING POLYNECLEOTIDE STRUCTURES - A system for stretching a polynucleotide structure includes a first electrode configured to generate an electrostatic force perpendicular to a surface of the first electrode and to apply the electrostatic force to the polynucleotide structure to pin an end region of the polynucleotide structure near the surface of the first electrode, and a second electrode configured to generate an electric force along an axial direction of the polynucleotide structure to stretch the polynucleotide structure along the axial direction of the polynucleotide structure into a fully extended form. | 2022-09-15 |
20220290119 | Astaxanthin Over-Producing Strains of Phaffia Rhodozyma - The present invention relates to novel yeast strains of | 2022-09-15 |
20220290120 | PLASMIDS FOR GENE EDITING - The present invention pertains to single plasmid systems comprising sequences encoding programmable proteins, one or more guides, optionally donor polynucleotides, and optionally anti-CRISPR molecules, for gene editing. These plasmid systems allow for genomic engineering of bacterial strains that are difficult to transform and increase the efficiency of genomic engineering in tractable strains. Additionally, the single plasmids can be configured to provide for the transformation of a number of different bacterial strains using the same plasmid. | 2022-09-15 |
20220290121 | Combinatorial Adenine and Cytosine DNA Base Editors - Engineered bifunctional adenine and cytosine base editor (BACE) variants that enable expanded amino acid modifications and methods of using the same. Described herein are fusion proteins containing adenosine deaminases, cytidine deaminases, catalytically impaired CRISPR-Cas proteins (e.g., Cas9, CasX or Cas12 nucleases), linkers, nuclear localization signals (NLSs) and uracil-n-glycosylase inhibitors (UGIs) that enable the CRISPR-guided programmable introduction of simultaneous A-to-G (T-to-C) and C-to-T (G-to-A) substitutions in DNA. | 2022-09-15 |