38th week of 2011 patent applcation highlights part 43 |
Patent application number | Title | Published |
20110229903 | DETERMINATION OF IMMUNOGLOBULIN ENCODING NUCLEIC ACID - It is reported herein a method for the determination of the amount of immunoglobulin-encoding mRNA comprising: a) providing a sample, b) performing a polymerase chain reaction for amplifying the light chain with the primers of SEQ ID NO: and 24 and the probe of SEQ ID NO: 33, and/or c) performing a polymerase chain reaction for amplifying the heavy chain with the primers of SEQ ID NO: 19 and 21 and the probe of SEQ ID NO: 40, and d) quantitating with an efficiency of 2.0. The primers with SEQ ID NOs 23 and 24 bind at positions CL 247-266 and CL166-185, respectively, and the probe with SEQ ID NO: 33 binds at 189-212 in human IgG koppa chain. The primer with SEQ ID NO: 19 binds at CH region 2 position 220-237 and the primer with SEQ ID NO: 21 binds at CH region 3 position 114-133. Finally the probe with SEQ ID NO: 40 binds from position 315 in CH2 to position 7 in CH3. | 2011-09-22 |
20110229904 | RECOMBINANT CONSTRUCT FOR DETECTION OF HALOGENATED AROMATIC HYDROCARBONS - The present invention describes a recombinant construct for detection of halogenated aromatic hydrocarbon compounds. A method for detecting halogenated aromatic hydrocarbon compounds using the recombinant construct is also described. | 2011-09-22 |
20110229905 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING CANCER AND NEURODEGENERATIVE DISEASES RLATED TO BECLIN-1 - The present invention relates to antibodies specific for human Beclin-1 protein phosphorylated at position Thr 119 and uses thereof. In particular, these antibodies are useful in diagnosing diseases associated with impaired autophagy including cancer and neurodegenerative diseases. The invention further relates to human Beclin-1 mutated at position 119 with a phospho-mimicking residue and uses thereof for treating cancer and neurodegenerative diseases. | 2011-09-22 |
20110229906 | Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS - This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS), particularly treatment regimens including a protease inhibitor. The invention further relates to the means and methods of monitoring the clinical progression of HIV infection and its response to antiretroviral therapy using phenotypic or genotypic susceptibility assays. | 2011-09-22 |
20110229907 | USE OF CARDIAC HORMONES TO ASSESS RISK OF CARDIOVASCULAR COMPLICATION FROM VOLUME OVERLOAD - The disclosure relates to the use of cardiac hormones, particularly natriuretic peptides, for assessment of risk of suffering from a cardiovascular complication, particularly heart disease or acute coronary syndrome, as a consequence of intravasal volume overload. In particular, the disclosure relates to a method for diagnosing the risk of a patient whose intravasal volume is increased or will be increased of suffering from a cardiovascular complication as a consequence of the increase of intravasal volume, comprising the steps of (a) taking a body fluid or tissue sample, and (b) measuring, preferably in vitro, the level of a cardiac hormone such as NT-proBNP. | 2011-09-22 |
20110229908 | METHODS AND PRODUCTS FOR MEASURING FREE IMMUNOGLOBULIN LIGHT CHAIN MOLECULES - The present invention provides improved methods for measuring the ratio of free K immunoglobulin light chain molecules to free λ immunoglobulin light chain molecules in a test sample, using a monoclonal antibody that specifically binds to free K and a monoclonal antibody that specifically binds to free λ. The application also provides specific monoclonal antibodies that can be used in the method of the invention, as well as kits containing said monoclonal antibodies. | 2011-09-22 |
20110229909 | RHO1-Gamma Amino Butyric Acid C Receptor-Specific Antibodies - This invention provides antibodies immunologically specific for ρ1-GABA | 2011-09-22 |
20110229910 | Fluorescent Substrates for Neurotransmitter Transporters - The invention is based on the finding that IDT307 and analogs thereof are fluorescent substrates transported by several neurotransmitter transporters. Provided are methods for the analysis of neurotransmitter transport and binding using IDT307 and its analogs. The invention also provides rapid methods for screening for modulators of neurotransmitter transport. | 2011-09-22 |
20110229911 | AZUROPHILIC GRANULE PROTEASES AS MARKERS IN CARDIOLOGICAL DISEASES - The present invention is concerned with an assay for detecting and/or determining the level of a protease from azurophilic granules of polymorphonuclear neutrophils or a complex thereof with an endogenous inhibitor for risk stratification and/or prognosis and/or therapy control and/or monitoring of a patient having a cardiological disease or condition. | 2011-09-22 |
20110229912 | ANTI-PREPROPROTEIN AND ANTI-PREPROTEIN ANTIBODIES AS IMMUNOHISTOCHEMICAL MARKERS - It is disclosed herein that antibodies specific for preproproteins or preproteins, which are synthesized by certain types of cells or tissues, can be used in immunohistochemistry assays to discriminate between the intracellular component of the protein (including the preproprotein, preprotein and/or proprotein forms of the protein) from the secreted component of the same protein. Accordingly, provided herein is an immunohistochemical method for specific detection of the intracellular form of a protein in a biological sample using an antibody specific for the preproprotein or preprotein form of the protein. In particular examples, the protein is albumin or an immunoglobulin light chain. Also disclosed herein are preproprotein-specific ore preprotein-specific antibodies that can be used to detect specific cell types, tissue lesions or other pathological foci and metastases by IHC. In particular, antibodies that specifically bind human preproalbumin, but do not bind the secreted form of albumin are disclosed. | 2011-09-22 |
20110229913 | Method for Amplification of Signal in Immunochromatographic Assay and Immunochromatographic Kit Using the Method - The present invention relates to a method for amplifying a signal in an immunochro-matographic assay for high-sensitivity detection of an analyte and an immunochromatographic kit using the method, which amplifies a signal by controlling a flow rate by discrimination between the size of a first indicator and the size of a second indicator. According to an aspect of the present invention, a method for amplifying a signal in an im | 2011-09-22 |
20110229914 | Use of Antibody Secreting Cell Elispot To Assess Antibody Responses Following Antigen Exposure - Disclosed are methods and kits for early detection of antigen exposure through the presence or absence of antigen-specific antibodies. | 2011-09-22 |
20110229915 | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE - The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of Epidermal growth factor, Complement C3, Interleukin-4, Interleukin-1 alpha, Tubulointerstitial nephritis antigen, Transforming growth factor beta-1, Bone morphogenetic protein 7, Osteopontin, Netrin-1, and Growth-regulated alpha protein as diagnostic and prognostic biomarkers in renal injuries. | 2011-09-22 |
20110229916 | NANOFIBERS WITH HIGH ENZYME LOADING FOR HIGHLY SENSITIVE BIOSENSORS - The invention provides high enzyme loading nanofibers and processes utilized in their fabrication, the nanofibers suitable for use as a new class of highly sensitive and stable biosensors capable of monitoring glucose at low levels. The biosensors, comprising nanofiber enzyme materials fabricated from organic solvent-based polymer-enzyme systems, can be used effectively in non-invasive transdermal biosensing applications. | 2011-09-22 |
20110229917 | MULTIPLEX LIQUID TISSUE.TM. METHOD FOR INCREASED PROTEOMIC COVERAGE FROM HISTOPATHOLOGICALLY PROCESSED BIOLOGICAL SAMPLES, TISSUES AND CELLS - The invention provides methods for multiplex analysis of biological samples of formalin-fixed tissue samples. The invention provides for a method to achieve a multiplexed, multi-staged plurality of Liquid Tissue preparations simultaneously from a single histopathologically processed biological sample, where the protocol for each Liquid Tissue preparation imparts a distinctive set of biochemical effects on biomolecules procured from histopathologically processed biological samples and which when each of the preparations is analyzed can render additive and complementary data about the same histopathologically processed biological sample. | 2011-09-22 |
20110229918 | Method of Quantifying Transient Interactions Between Proteins - The invention relates to a precursor for producing sintered metallic components, a method for producing the precursor and the production of the components. The object of the invention is to disclose possibilities of being able to produce sintered metallic components, which render possible an increased physical density and a reduced shrinkage on the fully sintered component. With a precursor according to the invention for the production of sintered metallic components, a coating layer is formed on a core, which is formed from respectively one particle of a first metallic powder. The coating layer is formed with a second powder and a binder. The first powder thereby has a particle size d | 2011-09-22 |
20110229919 | COMBINATION OF SPLA2 ACTIVITY AND OXPL/APOB CARDIOVASCULAR RISK FACTORS FOR THE DIAGNOSIS/PROGNOSIS OF A CARDIOVASCULAR DISEASE/EVENT. - A method of identifying a subject having or at risk of having or developing a cardiovascular disease and/or a cardiovascular event, includes:
| 2011-09-22 |
20110229920 | SCREENING METHODS FOR IDENTIFYING SPECIFIC STAPHYLOCOCCUS AUREUS INHIBITORS - Methods of inhibiting | 2011-09-22 |
20110229922 | SCREENING ASSAYS FOR THE IDENTIFICATION OF BACE2 INHIBITORS - The present invention relates to screening assays for the identification of BACE2 inhibitors. | 2011-09-22 |
20110229923 | CRYSTAL OF A CYTOCHROME-LIGAND COMPLEX AND METHODS OF USE - The teachings relates to the three-dimensional structure of a crystal of a cytochrome protein complexed with a ligand. The three-dimensional structure of four cytochrome P450 2A6-ligand complexes are disclosed. Cytochrome P450 2A6-ligand crystal structures, wherein the ligand is an inhibitor molecule, are useful for providing structural information that may be integrated into drug screening and drug design processes. Thus, the teachings also relate to methods for utilizing a crystal structure of a cytochrome P450 2A6-ligand complex for identifying, designing, selecting, or testing inhibitors of the cytochrome protein. Such inhibitors are useful as therapeutics for the treatment or modulation of i) diseases; ii) disease symptoms; or iii) the effect of other physiological events mediated by the cytochrome. | 2011-09-22 |
20110229924 | Fluorescent ion indicators and their applications - Fluorescent dyes useful for preparing fluorescent metal ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators for the detection, discrimination and quantification of metal cations. | 2011-09-22 |
20110229925 | ASSAYS FOR PERFORMANCE OF ORGANISMS IN PHENOTRONS - A phenotron assay can be used for determining an adverse effect on health by: identifying an exposure condition to be studied for an adverse effect on the health of an organism; providing a phenotron having one or more sensors each configured to sense a signal; introducing one or more test founder organisms into the phenotron, said test founder organisms each having a signal emitting tag that is sensed by the one or more sensors and each being exposed to the exposure condition; introducing one or more control founder organisms into the phenotron, said control founder organisms each having a signal emitting tag that is sensed by the one or more sensors and none of said control founder organisms being exposed to the exposure condition; collecting, from the one or more sensors, signals from the tags to obtain data indicative of a parameter of the health of the one or more test founder organisms compared to the one or more control founder organisms; and determining from the data whether the exposure condition has an adverse effect on the health of the one or more test founder organisms. | 2011-09-22 |
20110229926 | STORING METHOD OF MEASURING APPARATUS OF AIRBORNE FLOATING BACTERIA - [Problem] To present a storing method of a measuring apparatus of airborne floating bacteria capable of preventing contamination of the measuring apparatus by airborne floating bacteria and growth of airborne floating bacteria in the measuring apparatus during storage of the measuring apparatus of airborne floating bacteria. | 2011-09-22 |
20110229927 | SAMPLE PORT OF A CELL CULTURE SYSTEM - Disclosed herein is a cell culturing system comprising a culturing chamber for culturing a biological cell in a growth medium and a sensor for measuring a signal in the spent growth medium, wherein the culturing chamber is provided in a mesoscale bioreactor platform with an inlet opening for an influent stream of growth medium and a outlet opening for an effluent stream of spent growth medium, said outlet opening, said spent growth medium being in fluid communication with a sample port for releasable adoption of the sensor. Furthermore, a method of measuring an effluent stream of spent growth medium from a culturing chamber in the cell culturing system is disclosed. | 2011-09-22 |
20110229928 | DEVICE AND METHOD FOR MICROWAVE ASSISTED CRYO-SAMPLE PROCESSING - Embodiments are provided that provide for devices and methods for microwave-assisted cryo-sample processing. In some embodiments, a system for microwave-assisted cryo-sample processing of a sample includes a chamber adapted to receive microwave radiation and a device disposed in the chamber that is configured to maintain a sample under cryo conditions during irradiation of the sample with microwave radiation. | 2011-09-22 |
20110229929 | Arsenical Fluorescent Agents and Assays - The invention provides methods and compositions for labeling dithiol-containing analytes. | 2011-09-22 |
20110229930 | MICROORGANISM COMPRISING PARTICLES AND USES OF SAME - A particle is disclosed. The particle comprising: (i) at least one inner core which comprises a solid matrix of nutrients for microorganism growth; (ii) an inner membrane being fabricated from a water-soluble polymer, the inner membrane surrounding the inner core and a population of dried microorganisms; and (iii) an outer porous membrane surrounding the inner membrane, the outer porous membrane being insoluble in water. Methods of generating same, propagating microorganisms within and uses of same are also disclosed. | 2011-09-22 |
20110229931 | Engineering intracellular sialylation pathways - Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using recombinant DNA technology and substrate feeding approaches to enable the production of sialylated glycoproteins in cells of interest. These carbohydrate engineering efforts encompass the implementation of new carbohydrate bioassays, the examination of a selection of insect cell lines and the use of bioinformatics to identify gene sequences for critical processing enzymes. The compositions comprise cells of interest producing sialylated glycoproteins. The methods and compositions are useful for heterologous expression of glycoproteins. | 2011-09-22 |
20110229932 | ARTIFICIAL CHROMOSOME VECTOR - According to the present invention there is provided a method of producing a protein in a eukaryotic cell line, comprising the steps of a) providing a backbone of an artificial chromosome, b) recombining the nucleic acid encoding said protein into said backbone to generate an expression vector, c) introducing said expression vector into a eukaryotic host cell line to obtain a eukaryotic expression cell line, d) cultivating said expression cell line to produce said protein, and e) isolating said protein. The invention further relates to respective vectors and transgenic cell lines. | 2011-09-22 |
20110229933 | HIGH TITER ANTIBODY PRODUCTION - The present invention provides, in part, methods for recombinantly expressing proteins at a high level along with cell culture media for doing the same. | 2011-09-22 |
20110229934 | PROCESS FOR THE PRODUCTION OF THE ACTINOBACILLUS PLEUROPNEUMONIAE TOXINS APXI OR APCIII IN A LIQUID CULTURE MEDIUM UNDER SUPPLY OF AIR ENRICHED IN CARBON DIOXIDE - The current invention pertains to a method to produce RTX-toxins ApxI or ApxIII by culturing | 2011-09-22 |
20110229935 | PROCESS FOR THE PRODUCTION OF THE ACTINOBACILLUS PLEUROPNEUMONIAE TOXIN APXI EMPLOYING A CULTURE MEDIUM COMPRISING CALCIUM-BOROGLUCONATE COMPLEX - The present invention pertains to a method to produce RTX-toxin Apxl by culturing | 2011-09-22 |
20110229936 | Polypeptides Having Beta-Glucosidase Activity And Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 2011-09-22 |
20110229937 | CORYNEBACTERIUM GLUTAMICUM GENES ENCODING REGULATORY PROTEINS INVOLVED IN THE PRODUCTION OF METHIONINE - Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins from | 2011-09-22 |
20110229938 | Method For Amplifying Locus In Bacterial Cell - Certain aspects of this disclosure relate to a method of amplifying a genomic locus. In certain embodiments, the method may comprise: a) contacting a population of bacterial host cells with an inhibitor of an essential enzyme, where the bacterial host cells comprise a genomic locus of the structure: A | 2011-09-22 |
20110229939 | METHOD FOR AMPLIFYING DOUBLE STRANDED TARGET SEQUENCE IN DOUBLE STRANDED DNA - The present invention relates to a nested PCR with high specificity. The present invention provides a method for amplifying a target sequence ( | 2011-09-22 |
20110229940 | METHOD FOR PRODUCING L-AMINO ACID - The present invention relates to a method for producing an L-amino acid by reacting an enantiomeric mixture of an N-succinyl amino acid with L-succinylase in the presence of N-acylamino acid racemase to specifically hydrolyze the L-form. In particular, the present invention relates to a method for producing an L-amino acid in high yield by using an N-succinyl amino acid whose dissolved concentration is particularly low as a raw material to perform a reaction while precipitating the produced L-amino acid out of the reaction system. The present invention enables efficient production of an L-amino acid having high optical purity, particularly an L-amino acid useful as a raw material for products such as pharmaceutical products and agricultural chemicals. | 2011-09-22 |
20110229941 | Novel Gene Cluster - Novel isolated DNA sequences which comprise all or part of a gene cluster encoding sanglifehrin synthase, processing and regulatory genes involved in the biosynthesis of a mixed non-ribosomal peptide/polyketide compound, or mutants having altered biosynthetic capability, polypeptides or mutants thereof encoded by DNA or the mutants, vectors containing the DNA or the mutants thereof, host cells transformed with the DNA, the mutants thereof, or the vector, and a method for producing sanglifehrin compounds. Compounds with cyclophilin inhibition activity used as immunosuppressants, antivirals or cardiac protection agents. | 2011-09-22 |
20110229942 | Microbial Conversion of Oils and Fatty Acids to High-Value Chemicals - Microorganisms for the production of high-value chemicals from free fatty acids are provided. The microorganisms comprise genetic mutations that alter fatty acid metabolism. The genetic mutations include a mutation or deletion of a fadR gene in which the FadR enzyme activity is partially or substantially eliminated and a mutation in an atoC gene that provides overexpression of the microorganism's ato operon. Methods of using the microorganisms to produce high-value chemicals are also provided. The high-value chemicals include ethanol, methyl acetate, succinate, gamma-butyrolactone, 1,4-butanediol, acetone, iso-propanol, butyrate, butanol, mevalonate, propionate, ethanolamine and 1,2-propanediol. | 2011-09-22 |
20110229943 | METHODS FOR CONVERTING GLUCOSE TO ASCORBIC ACID - Described herein are novel nucleic acids, proteins and methods that can be used to provide new catalysts with desirable traits for industrial processes. In particular, novel reductases isolated from the environment using PCR methods are described. | 2011-09-22 |
20110229944 | FAD4, FAD5, FAD5-2, AND FAD6, Novel Fatty Acid Desaturase Family Members and Uses Thereof - The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturase family members. The invention also provides recombinant expression vectors containing desaturase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., DHA. | 2011-09-22 |
20110229945 | DICARBOXYLIC ACID PRODUCTION BY FERMENTATION AT LOW PH - The present invention relates to a process for the production of a dicarboxylic acid. The process comprises fermenting a yeast in the presence of a carbohydrate-containing substrate and low amounts of oxygen at a pH value at which at least 50% of the dicarboxylic acid is in the acid form. The process of the present invention allows for high yields of the dicarboxylic acid product and is more cost-effective than existing processes in which the salt is produced which during recovery has to be converted to the acid. It also leads to a simpler and more convenient downstream processing. | 2011-09-22 |
20110229946 | MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL, 4-HYDROXYBUTANAL, 4-HYDROXYBUTYRYL-COA, PUTRESCINE AND RELATED COMPOUNDS, AND METHODS RELATED THERETO - The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine. | 2011-09-22 |
20110229947 | Novel Ethanologenic Clostridium species, Clostridium coskatii - A novel clostridia bacterial species ( | 2011-09-22 |
20110229948 | METHOD FOR PRODUCING ETHANOL FROM A SUSTAINABLE RENEWABLE BIOMASS FEEDSTOCK - Disclosed is a method of producing ethanol from a sustainable renewable biomass feedstock. The ethanol is produced in a processing plant contiguous to the acreage providing the biomass. The process is a closed loop operation having a dedicated crop grown year round producing multiple crops per acre. The biomass feedstock is a sugar containing feedstock such as sweet sorghum and is grown year round for producing ethanol. | 2011-09-22 |
20110229949 | GENETICALLY MODIFIED YEAST STRAIN - A polyploid transformed yeast cell comprising a deleted or disrupted GDH1 gene encoding an NADPH-dependent glutamate dehydrogenase. The polyploid yeast cell shows increased production of ethanol and reduced production of glycerol when compared with a control polyploid yeast cell. | 2011-09-22 |
20110229950 | METHOD FOR ETHANOL PRODUCTION AND EXTRACTION - A method includes operating an apparatus having a mash circulating and recirculating system with pump and fermentation tank, an atmosphere circulating and recirculating system with blower for recirculating atmosphere between the tank and an ethanol-removal station, and an integrated refrigerating heat-transfer system with first coils remote from the tank for condensing out ethanol from the atmosphere, and second coils for warming the mash. The entire apparatus can be up-sized or down-sized for specific applications. In one form, the system includes electrically-driven pump, blower, and refrigeration compressors, with the external energy consumption being entirely electrical and kept surprisingly low. | 2011-09-22 |
20110229951 | BACTERIA-BASED GAS GENERATOR - Disclosed is an apparatus having: a pressure chamber and a gas-producing microorganism within the chamber. The pressure chamber is capable of maintaining a gas pressure of at least 0.5 psi above atmospheric pressure. | 2011-09-22 |
20110229952 | METHOD AND APPARATUS FOR AVALANCHE-MEDIATED TRANSFER OF AGENTS INTO CELLS - The present invention provides a method and apparatus for transferring an agent into a cell. The method includes the steps of providing an agent outside of a cell and generating a vapor bubble and a plasma discharge between an avalanche electrode and a conductive fluid surrounding the cell. The vapor bubble and plasma discharge generate a mechanical stress wave and an electric field, respectively. The combination of this mechanical stress wave and electric field results in permeabilization of the cell, which in turn results in transfer of the agent into the cell. | 2011-09-22 |
20110229953 | METHOD FOR PRODUCING DIFFERENT POPULATIONS OF MOLECULES OR FINE PARTICLES WITH ARBITRARY DISTRIBUTION FORMS AND DISTRIBUTION DENSITIES SIMULTANEOUSLY AND IN QUANTITY, AND MASKING MEMBER THEREFOR - The formation in quantity of various different populations of a substance being studied with multiple combinations of distribution form and distribution density by dripping a suspension of a single concentration of the substance onto a masking member of a certain specified structure placed on a substrate by making use of the sedimentation of said substance. | 2011-09-22 |
20110229954 | Nuclease Reduction - A method for reducing nuclease activity in a subtilisin solution obtained from a fermentation broth comprising a) adjusting the pH of the subtilisin solution to a pH in the range of from pH 8.5 to pH 10.5; b) adding a polyol; c) adjusting the temperature of the subtilisin solution to a temperature in the range of from 50° C. to 80° C.; whereby the nuclease activity is reduced to less than 5% of the initial value and the subtilisin activity is maintained at more than 80% of the initial value. | 2011-09-22 |
20110229955 | LUCIFERASES AND METHODS FOR MAKING AND USING THE SAME - Briefly described, embodiments of this disclosure include polynucleotides that encode mutant | 2011-09-22 |
20110229956 | Novel Variant Hyprocrea Jecorina CBH1 Cellulases - Described herein are variants of | 2011-09-22 |
20110229957 | POLYMER-MEDIATED ELECTROMAGNETIC FIELD-BASED PARTICLE CONCENTRATOR - There remains an unmet need for methods to efficiently concentrate and isolate small particles, such as nano-sized and micron-sized particles. The methods herein provide means to fulfill this need through the combination of two independent particle-concentrating mechanisms, yielding unprecedented control, confinement, and concentration enhancement ability. The method is carried out in a reversible and spatially controllable manner. Useful applications include diagnostics and bioparticle separation, material science and research uses, among other uses. | 2011-09-22 |
20110229958 | Host Cells for Production of Isoprenoid Compounds - Methods for synthesizing isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a different enzyme in the mevalonate pathway for producing isopentenyl pyrophosphate. A related method comprises introducing into a host microorganism an intermediate in the mevalonate pathway and at least one heterologous nucleic acid sequence, each sequence coding for an enzyme in the mevalonate pathway necessary for converting the intermediate into isopentenyl pyrophosphate. The invention also provides nucleic acid sequences, enzymes, expression vectors, and transformed host cells for carrying out the methods. | 2011-09-22 |
20110229959 | ENGINEERED MICROORGANISMS WITH ENHANCED FERMENTATION ACTIVITY - Provided herein are genetically modified microorganisms that have enhanced fermentation activity, and methods for making and using such microorganisms. | 2011-09-22 |
20110229960 | TAPE MAGAZINE FOR A HAND-HELD DEVICE - The present invention concerns a tape magazine especially for a hand-held device for analysing a body fluid with a test tape that can be unwound from a storage unit and wound onto a waste unit where the waste unit can be driven in order to wind forward the test tape. The invention provides that a lock which keeps the test tape under tension is integrated in the tape magazine at least on the storage unit. The present invention also concerns a hand-held device with such a tape magazine. The present invention also concerns a hand-held device with a mechanical drive for the test tape and a disposable hand-held device with polymer-based electronic components. | 2011-09-22 |
20110229961 | ACTIVE MICROFLUIDIC SYSTEM FOR IN VITRO CULTURE - Described herein are systems and methods for microfluidic cell support, including a microfluidic cell support system and methods for its use. The microfluidic cell support system can include a base assembly, a manifold assembly, and a microfluidic celltray including a microcirculatory path in fluid communication with the manifold assembly. The microfluidic celltray can be microfluidically closed and mechanically open. In some aspects the microfluidic celltray contains one or more cell wells containing fluid for supporting living cell(s). In some aspects, the microcirculatory path provides active fluid flow between a microfluidic inflow channel and a microfluidic outflow channel. | 2011-09-22 |
20110229962 | TEMPERATURE-RESPONSIVE CELL CULTURE SUBSTRATE AND METHOD FOR PRODUCING THE SAME - A substrate having a pattern of two or more materials exhibiting different grafting efficiencies for a temperature-responsive polymer that varies its interaction with water in a temperature range of 0 to 80° C. by electron beam irradiation under the same conditions is grafted with the temperature-responsive polymer by simultaneously irradiating the surfaces of the materials with electron beams to obtain a temperature-responsive cell culture substrate. According to this method, a temperature-responsive cell culture substrate having a surface ( | 2011-09-22 |
20110229963 | STIRRER FOR A BIOREACTOR - A stirrer for a bioreactor has first and second opposed mountings fastened to the inner surfaces of opposite walls of the bioreactor and disposed along a common rotational axis. A first arm has an end connected to the first mounting for rotation about the rotational axis and for pivoting about a first pivot axis that is transverse to the rotational axis. A second arm has an end connected to the second mounting for rotation about the rotational axis and for pivoting about a second pivot axis that is transverse to the rotational axis. Ends of the arms are coupled for pivoting about at least one additional pivot axis that is transverse to the rotational axis. | 2011-09-22 |
20110229964 | Fusion Protein Delivery System and Uses Thereof - The present invention provides a composition of matter, comprising: DNA encoding a viral Vpx protein fused to DNA encoding a protein. In another embodiment of the present invention, there is provided a composition of matter comprising: DNA encoding a viral Vpr protein fused to DNA encoding a protein. The present invention further provides DNA, vectors and methods for expressing a lentiviral pol gene in trans, independent of the lentiviral gag-pol. A gene transduction element is optionally delivered to a lentiviral vector according to the present invention. Also provided are various methods of delivering a virus inhibitory molecule to a target in an animal. Further provided is a pharmaceutical composition. | 2011-09-22 |
20110229965 | Methods of Preparing Mesenchymal Stem Cells, Compositions and Kit Thereof - The present invention discloses a method of isolation, pooling and further culturing of Mesenchymal Stem cells (MSC) for clinical application. Present invention also discloses the method of establishing Master Cell bank, followed by Working Cell Bank from which the final therapeutic composition referred to as Investigational Product/Investigational Medicinal Product comprising of allogenic bone marrow-derived MSC is formulated for clinical applications. | 2011-09-22 |
20110229966 | Nanoparticle-Based Gene Delivery Systems - The present invention provides a gene delivery system containing nanoparticles. In more detail, the present invention provides a gene delivery system containing (a) a nanomaterial; (b) an oligonucleotide as an universal binding partner covalently linked to the surface of the nanomaterial; and (c) a cargo comprising (i) a complementary oligonucleotide containing a nucleotide sequence complementary to the universal binding partner as a binding counter-partner, and (ii) an inhibitory molecule having a nucleotide sequence complementary to a target gene of interest to be inhibited or an inducible molecule having a nucleotide sequence of a target gene of interest to be expressed. The present invention is a gene delivery system capable of feasibly deliver aptamer, siRNA, shRNA, miRNA, ribozyme, DNAzyme, PNA or gene as well as antisense oligonucleotide into the cells. In addition, the present invention is more efficient than the commercially available gene transfer reagent in respect to the degree of knockdown of target protein expression. | 2011-09-22 |
20110229967 | METHOD OF CULTURING CONIFER SOMATIC EMBRYOS USING S(+)-ABSCISIC ACID - A method for promoting maturation and development of vigorous conifer (gymnosperm) somatic embryos comprising the use of S(+)-ABA as the substantive form of ABA. | 2011-09-22 |
20110229968 | ETHANOL RESISTANCE SACCHAROMYCES CEREVISIAE GP-01 BY PROTOPLAST FUSION, METHOD FOR MANUFACTURING THEREOF, METHOD FOR MANUFACTURING YEAST CONTAINING HIGH CONTENT OF BIO ORGANIC GERMANIUM BY USING SACCHAROMYCES CEREVISIAE GP-01 AND HIGH WATER SOLUBLE SODIUM METAGERMANATE AS A GERMANIUM SOURCE - A biologically pure culture of | 2011-09-22 |
20110229969 | Cell Line for Propagation of Highly Attenuated AlphaViruses - The present invention provides an avian cell that is derived from an avian host cell and stably carries at least one DNA sequence in the cell nucleus encoding an alphavirus polypeptide, a method for preparing such an avian cell, and its use in preparing an alphavirus replican particle. | 2011-09-22 |
20110229970 | DUAL-CHAMBER PERFUSION BIOREACTOR FOR ORTHOPEDIC TISSUE INTERFACES AND METHODS OF USE - The subject invention concerns a perfusion bioreactor device and methods of using the same. A bioreactor device of the invention can be used to grow cells and tissue in a controlled in vitro environment. A perfusion bioreactor device of the invention can have multiple perfusion chambers that can be controlled individually. Transverse or parallel flow of a fluid can be provided to each chamber. Cells can be seeded on a hydrogel and/or 3D scaffold to provide a 3D environment in the bioreactor device where the cells can adhere, proliferate, migrate, secrete growth and/or differentiation factors, and/or undergo differentiation, etc. The subject invention also concerns hydrogels and 3D scaffolds that can be used to grow and/or differentiate cells thereon. | 2011-09-22 |
20110229971 | RECOMBINANT VIRUS PRODUCTION USING MAMMALIAN CELLS IN SUSPENSION - The invention generally provides methods for producing recombinant AAV viral particles using cells grown in suspension. The invention provides recombinant AAV particles for use in methods for delivering genes encoding therapeutic proteins, and methods for using the recombinant AAV particles in gene therapy. | 2011-09-22 |
20110229972 | COMPOSITIONS AND METHODS FOR MATERIAL TRANSFER INTO CELLS - Methods for material transfer into a cell are provided according to the present invention which include electroporation of the cell in the presence of the material, such as nucleic acids, and 2,3-butanedione monoxime; and lipofection with a complex of a lipid-based carrier, such as liposomes, and the material, in the presence of 2,3-butanedione monoxime. | 2011-09-22 |
20110229973 | CONGENERIC, CHLORINATED, BROMINATED AND/OR IODISED, FLUORINATED AROMATIC COMPOUNDS COMPRISING TWO BENZOL RINGS IN THEIR BASIC STRUCTURE, METHOD FOR THEIR PRODUCTION AND USE THEREOF - Congeneric, halogenated, fluorinated aromatic compounds | 2011-09-22 |
20110229974 | METHOD AND A KIT FOR DETERMINING HUMAN OR ANIMAL BLOOD ON A SURFACE - A method for detecting human or animal blood traces on a surface is described. The method is fundamentally based on the reaction of luminol and includes the preliminary operation of atomizing an inorganic powder suspension, such as titania, silica, alumina, hydroxyapatite, or the like, onto the surface to be investigated, after which a luminol composition is atomized thereon, which comprises a luminol compound, a peroxidic oxidising agent and an alkaline agent in an amount providing a pH within the range of 10 to 14. Furthermore, a kit for carrying out the detection method of the invention is described. | 2011-09-22 |
20110229975 | Hybridization Compositions and Methods - The invention provides methods and compositions for hybridizing at least one molecule to a target. The invention may, for example, eliminate the use of or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences. | 2011-09-22 |
20110229976 | Sequencing of nucleic acid molecules by mass spectrometry - The present invention is related to a method for determining the nucleotide sequence of a nucleic acid molecule comprising the following steps:
| 2011-09-22 |
20110229977 | CHROMATOGRAPHIC ANALYSIS APPARATUS AND METHOD, AS WELL AS PROGRAM - Testing of a test article based on a color development state of a test area is achieved in an easy manner. A sample is deposited on a spreading layer of a test piece, and the test piece is loaded in a loading port of a chromatographic analysis apparatus. After a preset time has elapsed, color development states of the test area and a control area in an observation window are read as an image. A preprocessing unit applies preprocessing to the image, and then, spatial frequency components of the image are calculated. Then, pattern information is generated based on the spatial frequency components, and the pattern information is displayed on an information output unit. | 2011-09-22 |
20110229978 | IN SITU HEAT INDUCED ANTIGEN RECOVERY AND STAINING APPARATUS AND METHOD - Contemplated herein is an automated microscope slide antigen recovery and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments for individually and independently processing a plurality of individual microscope slides. The apparatus preferably features independently movable slide support elements each having an individually heatable heating plate. Each slide support element preferably supports a single microscope slide. Each microscope slide can be enclosed within an individual pressurizable reaction compartment. Pressures exceeding 1 atm or below 1 atm can be created and maintained in the reaction compartment prior to, during or after heating of the slide begins. Because of the ability to pressurize and regulate pressure within the reaction compartment, and to individually heat each slide, each slide and a liquid solution or reagent thereon can be heated to temperatures that could not be obtained without the enclosed pressurized environment of the reaction compartment. A reagent dispensing strip having a plurality of reconfigurable reagent modules may also be used. | 2011-09-22 |
20110229979 | RISPERIDONE IMMUNOASSAY - Novel conjugates and immunogens derived from risperidone and antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of risperidone and paliperidone in biological fluids. | 2011-09-22 |
20110229980 | OLIGONUCLEOTIDE PROBE AND USE THEREOF - The present teaching provides a fluorescent oligonucleotide probe having a high degree of design flexibility and wide applicability, as well as the use thereof. This is an oligonucleotide probe capable of forming a stem and loop, comprising at least one fluorophore located between adjacent nucleotides in the stem and is linked to a unit represented by Formula (1) and at least one quencher located at a site capable of pairing up with the at least one fluorophore located between the adjacent nucleotides in the stem and is linked to a unit represented by Formula (2). (In the formulae, X represents the fluorophore, Y represents the quencher, R1 represents an optionally substituted C | 2011-09-22 |
20110229981 | DETECTION OF SHED CD31, DIAGNOSIS OF ATHEROTHROMBOSIS AND AUTOIMMUNE DISORDERS, AND METHODS FOR ANALYZING SIGNALING PATHWAYS - The present invention stems from the finding that the extracellular domain of CD31 proteins present on blood leukocytes is shed and released in the circulation as a soluble form of CD31. A method for detecting shed CD31 is further disclosed. The invention therefore relates to a method for detecting a shed ectodomain of a transmembrane protein such as CD31 and to the use of such a method as a diagnostic tool. The invention further provides methods for determining whether a candidate protein is part of a molecular complex. | 2011-09-22 |
20110229982 | METHOD FOR BINDING A PROTEIN CONSISTING OF PROTEIN A OR CONSISTING OF AT LEAST ONE DOMAIN OF THE A TO E DOMAINS OF THE PROTEIN A TO THE SUBSTRATE - The object of the present invention is to provide a method for immobilizing the SpA protein on the surface of a substrate with high density without causing dimerization. | 2011-09-22 |
20110229983 | MARKING FUEL FOR AUTHENTICATION - A first fuel and a second fuel are marked with a marker that can be detected quantitatively in a predetermined concentration range. The second fuel is marked with a binary marker. Decreased concentration of the quantitative marker, presence of a binary marker, or both may be indicative of a fuel that is altered (e.g., mixed, laundered, diluted, or adulterated). Testing a fuel includes testing the fuel for a presence of a first marker in the fuel in a predetermined concentration range, and testing the fuel for a presence of a second marker. The presence of the first marker in the predetermined concentration range and an absence of the second marker may be indicative that the fuel is unaltered. The presence of the first marker in the fuel in a concentration less than the predetermined concentration range or the presence of the second marker may be indicative that the fuel is altered. | 2011-09-22 |
20110229984 | MATERIALS AND METHODS DIRECTED TO ASPARAGINE SYNTHETASE AND ASPARAGINASE THERAPIES - Materials and Methods for use in treating cell proliferative disorders related to asparagine metabolism are provided. Cell proliferative disorders include such cancers as forms of leukemia, ovarian cancers, melanomas, renal cancers, breast cancers, brain cancers, and other cancers. Methods include the use of RNA interference targeted at asparagine synthetase to enhance the efficacy of L-asparaginase therapies. | 2011-09-22 |
20110229985 | Fabrication of Magnetic Tunnel Junction (MTJ) Devices with Reduced Surface Roughness for Magnetic Random Access Memory (MRAM) - Reliability and yield of MTJ devices is improved by reducing surface roughness in the MTJ layers of the MTJ devices. Surface roughness is reduced by reducing surface roughness of layers below the MTJ layers such as the bottom electrode layer. Planarizing the bottom electrode layer through chemical mechanical polishing or etch back of spin-on material before depositing the MTJ layers decreases surface roughness of the bottom electrode layer and the MTJ layers. Alternatively, a capping layer may be planarized before deposition of the bottom electrode layer and MTJ layers to reduce surface roughness in the capping layer, the bottom electrode layer, and the MTJ layers. | 2011-09-22 |
20110229986 | Magnetic Memory Devices and Methods of Forming the Same - Provided are a magnetic memory device and a method of forming the same. The method may include forming a pinning pattern on a substrate; forming a first interlayer insulating layer that exposes the pinning pattern on the substrate; forming a pinned layer, a tunneling barrier layer and a second magnetic conductive layer on the pinning pattern; and forming a pinned pattern, a tunnel barrier pattern and a second magnetic conductive pattern by performing a patterning process on the pinned layer, the tunnel barrier layer and the second magnetic conductive layer. | 2011-09-22 |
20110229987 | METHOD FOR LOW TEMPERATURE ION IMPLANTATION - Techniques for low temperature ion implantation are provided to improve throughput. Specifically, the pressure of the backside gas may temporarily, continually or continuously increase before the starting of the implant process, such that the wafer may be quickly cooled down from room temperature to be essentially equal to the prescribed implant temperature. Further, after the vacuum venting process, the wafer may wait an extra time in the load lock chamber before the wafer is moved out the ion implanter, in order to allow the wafer temperature to reach a higher temperature quickly for minimizing water condensation on the wafer surface. Furthermore, to accurately monitor the wafer temperature during a period of changing wafer temperature, a non-contact type temperature measuring device may be used to monitor wafer temperature in a real time manner with minimized condensation. | 2011-09-22 |
20110229988 | PATTERN FORMING METHOD, PROCESSING METHOD, AND PROCESSING APPARATUS - According to the embodiments, a distribution of a recess portion shape is calculated based on a result obtained by measuring the recess portion shape of a first projection and recess pattern formed on a surface of a template. Next, a distribution of an application amount of a curing agent to a processing target layer is calculated based on the distribution of the recess portion shape, and the curing agent is applied to the processing target layer based on this distribution of the application amount of the curing agent. Next, a second projection and recess pattern is formed by transferring the first projection and recess pattern onto the curing agent by causing the curing agent to cure in a state where the first projection and recess pattern is in contact with the curing agent. | 2011-09-22 |
20110229989 | LARGE SCALE METHOD AND FURNACE SYSTEM FOR SELENIZATION OF THIN FILM PHOTOVOLTAIC MATERIALS - A method for fabricating a copper indium diselenide semiconductor film is provided using substrates having a copper and indium composite structure. The substrates are placed vertically in a furnace and a gas including a selenide species and a carrier gas are introduced. The temperature is increased from about 350° C. to about 450° C. to initiate formation of a copper indium diselenide film from the copper and indium composite on the substrates. | 2011-09-22 |
20110229990 | FORMING AND TRAINING PROCESSES FOR RESISTANCE-CHANGE MEMORY CELL - During the manufacture of a set of non-volatile resistance-switching memory elements, a forming process is performed in which a voltage is applied over forming period until a conductive filament is formed in a resistance-switching layer. A heat source at a temperature of 50° C. to 150° C. is applied to expedite the forming process while reducing the required magnitude of the applied voltage. Manufacturing time and reliability are improved. After the forming process, an expedited training process can be performed in which a fixed number of cycles of voltage pulses are applied without verifying the memory elements. Subsequently, the memory elements are verified by determining their read current in an evaluation. Another fixed number of cycles of voltage pulses is applied without verifying the memory elements, if the memory elements do not pass the evaluation. | 2011-09-22 |
20110229991 | SEMICONDUCTOR CHIP PACKAGE STRUCTURE FOR ACHIEVING FLIP-CHIP TYPE ELECTRICAL CONNECTION WITHOUT USING WIRE-BONDING PROCESS AND METHOD FOR MAKING THE SAME - A semiconductor chip package structure for achieving flip-chip electrical connection without using a wire-bonding process includes a package unit, a semiconductor chip, a first insulative layer, first conductive layers, a second insulative layer, and second conductive layers. The package unit has a receiving groove. The semiconductor chip is received in the receiving groove and has a plurality of conductive pads disposed on its top surface. The first insulative layer is formed between the conductive pads to insulate the conductive pads. The first conductive layers are formed on the first insulative layer and the package unit, and one side of each first conductive layer is electrically connected to the corresponding conductive pad. The second insulative layer is formed between the first conductive layers in order to insulate the first conductive layers from each other. The second conductive layers are respectively formed on the other opposite sides of the first conductive layers. | 2011-09-22 |
20110229992 | LIGHT EXTRACTION FILM FOR ORGANIC LIGHT EMITTING DIODE LIGHTING DEVICES - A multifunctional optical film for enhancing light extraction includes a flexible substrate, a structured layer, and a backfill layer. The structured layer effectively uses microreplicated diffractive or scattering nanostructures located near enough to the light generation region to enable extraction of an evanescent wave from an organic light emitting diode (OLED) device. The backfill layer has a material having an index of refraction different from the index of refraction of the structured layer. The backfill layer also provides a planarizing layer over the structured layer in order to conform the light extraction film to a layer of an OLED lighting device such as solid state lighting devices or backlight units. The film may have additional layers added to or incorporated within it to an emissive surface in order to effect additional functionalities beyond improvement of light extraction efficiency. | 2011-09-22 |
20110229993 | METHOD OF FABRICATING A LIGHT EMITTING DIODE CHIP HAVING PHOSPHOR COATING LAYER - A method of fabricating light emitting diode chips having a phosphor coating layer comprises providing a substrate having a plurality of light emitting diodes formed thereon; forming a conductive bump on at least one of the plurality of light emitting diodes; forming a phosphor coating layer over the substrate and the light emitting diodes; cutting the phosphor coating layer by a point cutter to remove an upper portion of the phosphor coating layer, so as to reduce a thickness of the phosphor coating layer and expose the conductive bump; and forming a plurality of individual light emitting diode chips having the phosphor coating layer by separating the plurality of light emitting diodes. | 2011-09-22 |
20110229994 | Method of manufacturing organic light emitting display device - A method of manufacturing an organic light emitting display device includes providing a substrate, the substrate including a first electrode on which a first photosensitive layer is formed, a second electrode on which a second photosensitive layer is formed, and an exposed third electrode, coating an organic layer on the substrate, and carrying out an ashing process to remove the organic layer and the second photosensitive layer and to partially remove the first photosensitive layer so as to avoid exposing the upper surface of the first electrode. | 2011-09-22 |
20110229995 | Silicon Nanoparticle White Light Emitting Device - Multiple films of red-green-blue (RGB) luminescent silicon nanoparticles are integrated in a cascade configuration as a top coating in an ultraviolet/blue light emitting diode (LED) to convert it to a white LED. The configuration of RGB luminescent silicon nanoparticle films harnesses the short wavelength portion of the light emitted from the UV/blue LED while transmitting efficiently the longer wavelength portion. The configuration also reduces damaging heat and/or ultraviolet effects to both the device and to humans. | 2011-09-22 |
20110229996 | METHOD FOR DISPOSING A COMPONENT - A method for disposing a component comprises: a step of preparing a substrate and a first liquid; preparing a component-containing liquid containing the components and a second liquid; a step of disposing the first liquid in a hydrophilic region; a step of bringing the component-containing liquid into contact with the first liquid disposed on the hydrophilic region; a step of removing the first liquid and the second liquid to dispose the component on the hydrophilic region. The hydrophilic region is composed of a component-disposing region and a liquid-capturing region formed on the periphery of the component-disposing region. The liquid-capturing region comprises a surface represented by the following chemical formula I. | 2011-09-22 |
20110229997 | METHOD FOR MANUFACTURING SEMICONDUCTOR LIGHT EMITTING DEVICE - In one embodiment, a method for manufacturing a semiconductor light emitting device characterized by bonding a first stacked body to a second stacked body is disclosed. The first stacked body includes a first substrate, a semiconductor layer, and a first metal layer. The second stacked body includes a second substrate and a second metal layer. The method can include overlaying the first metal layer and the second metal layer by shifting a cleavage direction of the first stacked body from a cleavage direction of the second stacked body. The method can include bonding the first stacked body and the second stacked body by increasing a temperature in a state of pressing the first stacked body and the second stacked body into contact. | 2011-09-22 |
20110229998 | Blue light emitting semiconductor nanocrystal materials - A semiconductor nanocrystal includes a core including a first semiconductor material and an overcoating including a second semiconductor material. A monodisperse population of the nanocrystals emits blue light over a narrow range of wavelengths with a high quantum efficiency. | 2011-09-22 |
20110229999 | FABRICATION METHOD OF LIGHT EMITTING DEVICE - Provided is a method for fabricating a light emitting device. The method for fabricating the light emitting device includes forming a buffer layer including a compound semiconductor in which a rare-earth element is doped on a substrate, forming a light emitting structure including a first conductive type semiconductor layer, an active layer, and a second conductive type semiconductor layer, which are successively stacked on the buffer layer, forming a first electrode layer on the light emitting structure, removing the substrate, and forming a second electrode layer under the light emitting structure. | 2011-09-22 |
20110230000 | MEMS DEVICE MANUFACTURING METHOD - A MEMS device manufacturing method including a break start point forming step of forming a break start point in a substrate along the areas corresponding to a plurality of crossing streets set on the substrate before forming a plurality of MEMS devices on the substrate, a device forming step of forming the MEMS devices in a plurality of areas partitioned by the areas corresponding to the crossing streets on the front side of the substrate after performing the break start point forming step, and a substrate breaking step of applying an external force to the substrate after performing the device forming step to thereby break the substrate along the areas corresponding to the crossing streets where the break start point is formed, thus dividing the substrate into the individual MEMS devices. | 2011-09-22 |
20110230001 | MULTIBIT ELECTRO-MECHANICAL MEMORY DEVICE AND METHOD OF MANUFACTURING THE SAME - A multibit electro-mechanical memory device comprises a substrate, a bit line on the substrate, a first interlayer insulating film on the bit line, first and second lower word lines on the first interlayer insulating film, the first and second lower word lines separated horizontally from each other by a trench, a spacer abutting a sidewall of each of the first and second lower word lines, a pad electrode inside a contact hole, first and second cantilever electrodes suspended over first and second lower voids that correspond to upper parts of the first and second lower word lines provided in both sides on the pad electrode, the first and second cantilever electrodes being separated from each other by the trench, and being curved in a third direction that is perpendicular to the first and second direction; a second interlayer insulating film on the pad electrode, first and second trap sites supported by the second interlayer insulating film to have first and second upper voids on the first and second cantilever electrodes, and first and second upper word lines on the first and second trap sites. | 2011-09-22 |
20110230002 | Local Oxidation of Silicon Processes with Reduced Lateral Oxidation - A method of forming an integrated circuit structure includes providing a silicon substrate, and implanting a p-type impurity into the silicon substrate to form a p-type region. After the step of implanting, performing an anneal to form a silicon oxide region, with a portion of the p-type region converted to the silicon oxide region. | 2011-09-22 |
20110230003 | PROCESS FOR FABRICATING A MULTILAYER STRUCTURE WITH POST-GRINDING TRIMMING - The invention relates to a process for fabricating a multilayer structure ( | 2011-09-22 |