38th week of 2022 patent applcation highlights part 11 |
Patent application number | Title | Published |
20220296687 | NEUROTOXIN COMPOSITIONS FOR USE IN TREATING NEUROLOGIC AND PSYCHIATRIC DISORDERS - Disclosed herein are compositions and methods for use in treating neurologic and psychiatric disorders. | 2022-09-22 |
20220296688 | TARGETING CAPN9/CAPNS2 ACTIVITY AS A THERAPEUTIC STRATEGY FOR THE TREATMENT OF MYOFIBROBLAST DIFFERENTIATION AND ASSOCIATED PATHOLOGIES - Provided herein are, inter alia, compositions and methods for identifying and using agents capable of inhibiting myofibroblast transition as well as methods for treating diseases associated with the same in a subject in need thereof. | 2022-09-22 |
20220296689 | PARASITIC NEMATODE VACCINE - There is discussed nematode antigens capable of causing an immune response in a host such that a protective effect is provided to the host in relation to the nematode. Antigens, compositions for the treatment of parasitic nematode infections, methods of prophylaxis and treatment of parasitic nematode infections, and vaccines to reduce and/or control parasitic nematode infections are provided. | 2022-09-22 |
20220296690 | ENGINEERED T CELLS AND USES THEREFOR - Lipocalin muteins specific to a predetermined antigen can be transduced into a T cell to bring therapeutic benefits to patients in need. In one example, a lipocalin mutein specific to a predetermined antigen (e.g., a target differentially expressed on the surface of a tumor cell) can be transduced into a T cell membrane to serve as an antigen receptor, offering benefits over conventionally deployed antibody-derived protein moieties such as a single chain variable fragment (scFv). Benefits include a more stable structure, leading to superior target engagement, for example. Further, lipocalin muteins specific to a predetermined antigen (e.g. an immunomodulatory target such as an immune checkpoint or costimulatory molecule) can be transduced into a T cell for secretion thereby, bringing an added therapeutic benefit. Specific examples of such modified T cells and methods of making and using the same are provided herein. | 2022-09-22 |
20220296691 | METHODS FOR TREATING CANCER WITH ACTIVATING ANTIGEN CARRIERS - The present application provides activating antigen carriers (AACs) for treating HPV-associated cancers. AACs are derived from anucleate cells in which at least one antigen and an adjuvant have been delivered intracellularly. In some embodiments, the AAC is administered in combination with a checkpoint inhibitor such as a CTLA4 antagonist and/or a PD-1/PD-L1 agonist. | 2022-09-22 |
20220296692 | USE OF AN ACTIVATABLE ANTI-PDL1 ANTIBODY AND AN ANTI-CTLA-4 ANTIBODY IN A NEOADJUVANT COMBINATION THERAPY FOR THE TREATMENT OF CANCER - The invention relates generally to use of a neoadjuvant combination therapy of an activatable anti-PDL1 antibody and an anti-CTLA-4 antibody for the treatment of cancer. | 2022-09-22 |
20220296693 | VACCINES AGAINST MALARIA TRANSMISSION - The invention pertains to methods and vaccines suitable for preventing or reducing malaria transmission. The vaccines block the interaction between α-tubulin from a malarial parasite and FREP-1 from the mid-gut of a malaria carrier mosquito, for example, | 2022-09-22 |
20220296694 | MYCOPLASMA BOVIS COMPOSITIONS - Disclosed herein are | 2022-09-22 |
20220296695 | COMPOSITIONS COMPRISING STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE-PROTEIN CONJUGATES AND METHODS OF USE THEREOF - The invention is related to multivalent immunogenic compositions comprising more than one | 2022-09-22 |
20220296696 | Immunogenic Antigens - The invention relates to composite antigens comprising an antigen obtained or derived from an antigenic epitope of one or more pathogens that induces an immune response in a mammal, an antigen obtained or derived from bacterial cell wall material that induces an immune response in a mammal such as LTA, PNG or LPS, and a T cell stimulating antigen such as CRM. Preferably the composite antigen comprises an immunogenic composition or a vaccine that is effective against the pathogen or can generate antibodies that can be collected that are protective against infection by the pathogen. In addition, the invention relates to vaccines comprising composite antigens and to method for treating and preventing an infection. | 2022-09-22 |
20220296697 | PORCINE CIRCOVIRUS TYPE 2 VLP VACCINE - Provided is PCV2 VLP that can be used as a vaccine for use in the field of animal husbandry and that has high molecular stability against physicochemical load. A fusion protein according to the present invention includes a capsid protein of porcine circovirus type 2 and an immunoglobulin-binding domain. | 2022-09-22 |
20220296698 | UNIVERSAL INFLUENZA VACCINE - Immunogenic compositions for inducing a universal immune response to influenza, and particularly influenza A, by eliciting anti-neuraminidase antibodies which provide protection against heterologous influenza infection. Compositions comprising recombinant baculovirus expression vectors expressing neuraminidase in cultured insect cells dispersed in a pharmaceutically-acceptable carrier comprising insect cell culture media, and optional adjuvant. Methods of inducing immune responses against influenza, and particularly influenza A, by eliciting anti-neuraminidase antibodies in a host animal susceptible to infection. | 2022-09-22 |
20220296699 | EFFECTIVE VACCINATION AGAINST PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS) VIRUS PRIOR TO WEANING - The invention provides isolated polynucleotide molecules that comprise a DNA sequence encoding an infectious RNA sequence encoding a genetically-modified North American PRRS virus, methods to make it and related polypeptides, polynucleotides, and various components. Vaccines comprising the genetically modified virus and polynucleotides and a diagnostic kit to distinguish between naturally infected and vaccinated animals are also provided. | 2022-09-22 |
20220296700 | SYNTHETIC PLASMID DNA VACCINE EXPRESSING A CODON-OPTIMIZED SARS-COV-2 SPIKE PROTEIN AND METHODS FOR ITS USE - A synthetic DNA vaccine against SARS-CoV-2 infection comprises a codon-optimized coding sequence for optimal mammalian expression of a pSARS2 spike glycoprotein (pSARS2-S). The signal peptide may be replaced with the signal peptide from the human IgG2 heavy chain. Systemic S1-specific IgG antibodies and neutralizing antibodies (nAbs) were significantly induced in mice at 2 weeks-post three injections with 100 μg of the pSARS2-S vaccine via intramuscular (IM) needle injection. IM immunization induced Th1-skewed and long-lasting IgG response in BALB/c mice. Immunogenicity and induction of nAbs were enhanced with a needle-free delivery system, wherein two doses were sufficient to elicit significant levels of systemic S1-specific IgG antibodies and nAbs via IM or intradermal immunization. | 2022-09-22 |
20220296701 | SYNTHETIC PLASMID DNA VACCINE EXPRESSING A CODON-OPTIMIZED SARS-COV-2 SPIKE PROTEIN AND METHODS FOR ITS USE - A synthetic DNA vaccine against SARS-CoV-2 infection comprises a codon-optimized coding sequence for optimal mammalian expression of a pSARS2 spike glycoprotein (pSARS2-S). The signal peptide may be replaced with the signal peptide from the human IgG2 heavy chain. Systemic S1-specific IgG antibodies and neutralizing antibodies (nAbs) were significantly induced in mice at 2 weeks-post three injections with 100 μg of the pSARS2-S vaccine via intramuscular (IM) needle injection. IM immunization induced Th1-skewed and long-lasting IgG response in BALB/c mice. Immunogenicity and induction of nAbs were enhanced with a needle-free delivery system, wherein two doses were sufficient to elicit significant levels of systemic S1-specific IgG antibodies and nAbs via IM or intradermal immunization. | 2022-09-22 |
20220296702 | PHARMACEUTICAL COMPOSITIONS COMPRISING ONCOLYTIC HERPES SIMPLEX VIRUS FOR SYSTEMIC ADMINISTRATION - Disclosed is a pharmaceutical composition comprising oncolytic herpes simplex virus expressing IL12 and PD-1 antibody for treatment of cancer through systemic administration. | 2022-09-22 |
20220296703 | COBMINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND ANTI-PD-1 OR ANTI-PD-L1 ANTIBODY - Therapeutic combinations of hepatitis B virus (HBV) vaccines and an anti-PD-1 or anti-PD-L1 antibody or antigen-binding fragment thereof are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infection, using the disclosed therapeutic combinations are also described. | 2022-09-22 |
20220296704 | VACCINE FORMULATIONS - A pharmaceutically compatible antioxidant for use in the treatment or the prevention of an unwanted immune response, the corresponding pharmaceutical and vaccine compositions, and the corresponding clinical and ex-vivo applications. | 2022-09-22 |
20220296705 | COMBINED USE OF ARTIFICIAL ADJUVANT VECTOR CELLS AND AN IMMUNOSTIMULANT - The present invention provides a composition for use in activating innate immunity, comprising an immunostimulant. The present invention also provides a combination use of an immunostimulant and an artificial adjuvant vector cell. | 2022-09-22 |
20220296706 | COMPOSITIONS COMPRISING SECRETORY IgA AND PROBIOTICS - The present invention relates to methods for producing compositions comprising secretory IgA and one or more probiotics. In particular, the invention relates to methods for producing compositions in which the secretory IgA and one or more probiotics are associated. The invention also relates to compositions obtainable by the methods and uses of the compositions, for example in reducing or preventing a non-viral infection and/or inflammation. | 2022-09-22 |
20220296708 | ALK1 RECEPTOR AND LIGAND ANTAGONISTS AND USES THEREOF - In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and antibodies that inhibit receptor-ligand interaction. | 2022-09-22 |
20220296709 | SONODYNAMIC THERAPY USING SONODYNAMICALLY ACTIVATED COORDINATION COMPLEXES OF TRANSITION METALS AS SENSITIZING AGENTS - A method for destroying cells and/or microorganisms in an organism includes the following steps: (a) administering to the organism a composition including a sonosensitizing compound containing at least one transition metal with three bidentate ligands; and (b) exposing the sonosensitizing compound in the organism to ultrasound, wherein the ultrasound is effective to activate the sonosensitizing compound to destroy at least one of the cells and the microorganisms in the organism. The ultrasound is preferably used in conjunction with electromagnetic therapies comprising photodynamic therapy, low-level laser therapy, and radiation therapy. The ultrasound is preferably administered at a duty cycle in the range from 5% to 95% at a power density of 10 W/cm | 2022-09-22 |
20220296710 | MODULAR PHAGE VECTOR PLATFORM FOR SONODYNAMIC THERAPY - The present invention relates to a phage or a composition that comprises it, wherein said phage expresses at least one specific recognition element and is furthermore conjugated with at least 300 molecules of a sonosensitiser. The invention further relates to the use of said phage in a sonodynamic therapy. | 2022-09-22 |
20220296711 | Ruthenium (II) Complexes and Conjugates Thereof for Use as Photosensitizer Agent in Photodynamic Therapy - The present invention relates to a compound of the following formula (I): | 2022-09-22 |
20220296712 | METHODS FOR TREATMENT USING PHTHALOCYANINE DYE-TARGETING MOLECULE CONJUGATES - Provided are compositions, combinations, and methods and uses for treating a subject having a tumor or lesion, including those not responsive or resistant to prior therapeutic treatments, such as prior immune checkpoint inhibitor treatments. In some aspects, the methods include administering to the subject a targeting molecule that binds CTLA-4 conjugated with phthalocyanine dye, such as IR700. In some cases, the methods include administering an immune modulatory agent. The tumor or lesion, in some cases, a first tumor, is illuminated with a wavelength of light suitable for the activation of the phthalocyanine dye of the conjugate. The provided methods and uses provide for growth inhibition, volume reduction, and elimination of tumors and tumor cells including primary tumors, metastatic tumor cells, and/or invasive tumor cells. Also provided are compositions, combinations, methods and uses for provoking or enhancing systemic and local immune responses and for synergistic responses against tumor growth. | 2022-09-22 |
20220296713 | BIOPHOTONIC COMPOSITIONS FOR TREATING SKIN AND SOFT TISSUE WOUNDS HAVING EITHER OR BOTH NON-RESISTANT AND RESISTANT INFECTIONS - The present document describes methods and uses of biophotonic compositions which comprise at least one oxidant and at least one chromophore capable of activating the oxidant, in association with a pharmacologically acceptable carrier for use in the treatment of skin and soft tissue wounds that have either or both non-resistant and resistant infections. | 2022-09-22 |
20220296714 | TARGETED NANO-PHOTOMEDICINES FOR PHOTODYNAMIC THERAPY OF CANCER - The present invention relates to a photosensitizer-containing nanoparticle, comprising a photosensitizer covalently bonded throughout at least a part of said nanoparticle to the nanoparticle matrix material and incorporated therein in a quasi-aggregated state. The present invention further relates to methods for producing the invention nanoparticles, and to methods of killing cancer cells by PDT treatment using the said nanoparticles. | 2022-09-22 |
20220296715 | METHOD FOR PREVENTING PRECIPITATION OF INJECTABLE SOLUTION CONTAINING p-BORONOPHENYLALANINE - An object of the present invention is to provide a method for preventing precipitation by storing an injection solution for boron neutron capture therapy. The present invention provides a method for preventing precipitation of an injection solution for boron neutron capture therapy, the injection solution containing p-boronophenylalanine or a pharmaceutically acceptable salt thereof; a sugar alcohol; and a pH adjusting agent, having a pH of 6.5 to 8.0 and an osmotic pressure ratio of 1.0 to 1.8, and being to be administered by intravenous drip injection. | 2022-09-22 |
20220296716 | BIOMIMETIC DRUG DELIVERY OF AN IMMUNOMODULATORY AGENT FOR THE TREATMENT OF OCULAR CONDITIONS - A method for treating an ocular disorder in a subject comprising administering a therapeutic agent-loaded carrier to an ocular site of the subject in need thereof, wherein the therapeutic agent loaded-carrier provides controlled delivery of the therapeutic agent under conditions suitable for recruiting regulatory T cells to an ocular region of interest or inducing regulatory T cells in an ocular region of interest. | 2022-09-22 |
20220296717 | THE USE OF STABLE ISOTOPES TO PROVE AUTHENTICATION OF MANUFACTURING LOCATION - The disclosure relates to a manufactured composition, material or device comprising at least two different nonradioactive isotope atoms. Each nonradioactive isotope atom is present in an amount sufficient to increase the total amount of the nonradioactive isotope atom above the total amount found in the manufactured composition, material or device in the absence of adding the nonradioactive isotope atom to increase said total amount. The ratio(s) of the at least two nonradioactive isotopes in the manufactured composition, material or device are measurably different than the ratio(s) found in the manufactured composition, material or device in the absence of adding the nonradioactive isotope atom to increase said total amount. | 2022-09-22 |
20220296718 | EXCIPIENT FOR BIOTHERAPEUTICS - The present invention relates to excipients for stabilizing active agents, in particular peptides, polypeptides, nucleic acids, viruses, virus-like particles, proton pump inhibitors and antibiotics. The excipient reduces aggregate and/or particle formation in preparations comprising said agents. The excipient is a diamide of a dicarboxylic acid comprising at least one N—H amido group, at least one unsubstituted or substituted N-hydroxyethylamido group and/or at least one unsubstituted N-hydroxymethylamido group. In particular, the excipient is N,N,N′,N′-tetrakis-(2-hydroxyethyl) adipinic acid amide. | 2022-09-22 |
20220296719 | SUSTAINED RELEASE THERMOSETTING GELS COMPRISING SODIUM CHANNEL BLOCKERS AND THE METHODS OF MAKING SAME - The present disclosure provides compositions comprising a thermosensitive hydrogel formulation of funapide and a tri-block polymer, and methods of use and manufacture of the compositions for management of acute pain or pain associated with surgical procedure. | 2022-09-22 |
20220296720 | COMPOSITE CHITOSAN-TANNIN-ACTIVE AGENT COMPOSITIONS AND METHODS OF MAKING AND USING SAME - Composite composition comprising chitosan, tannin, and an active agent and methods of making and using same. | 2022-09-22 |
20220296721 | MEMBRANE FOR STICKING TO LIVING ORGANISM, AND METHOD FOR PRODUCING SAME - A cellulose membrane according to an embodiment of the present disclosure is a self-supporting cellulose membrane having a thickness of between 20 nm and 1300 nm, inclusive, composed of regenerated cellulose having a weight average molecular weight of 150,000 or more. | 2022-09-22 |
20220296722 | CONJUGATES AND CONJUGATES FOR USE IN PREVENTING OR TREATING OF BRAIN DAMAGE AND NEURODEGENERATIVE DISEASES - Disclosed are conjugates including one or more compounds selected from of (i) an anti-inflammatory compound, and/or (ii) an antioxidant compound, and/or (iii) and antibiotic compound and/or, (iv) a metal chelating compound and at least one of (v) a blood-brain barrier compound and (vi) solubility enhancer moiety. The compounds of group (i)-(v) and the solubility enhancer moiety (vi), when present, are covalently bound together with one or more linkers. The blood-brain barrier targeting compound is monosaccharide and the solubility enhancer moiety is a phosphate group. Also disclosed are pharmaceutical compositions including such conjugates and uses of these conjugates and compositions for treating and/or prevention of neuro-degenerative diseases and brain damage due to traumatic and/or acquired brain injury. | 2022-09-22 |
20220296723 | PROCESSES FOR THE FORMULATION OF PNEUMOCOCCAL POLYSACCHARIDES FOR CONJUGATION TO A CARRIER PROTEIN - The present invention provides a number of process improvements related to the conjugation of capsular polysaccharides from | 2022-09-22 |
20220296725 | PYRROLOBENZODIAZEPINE ANTIBODY CONJUGATES - The present disclosure relates generally to antibody-drug conjugates comprising pyrrolo[2, 1-c][1, 4]benzodiazepine (PBD) drug moieties. The present disclosure also relates to methods of using these conjugates, e.g., as therapeutics and/or diagnostics. | 2022-09-22 |
20220296726 | BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TREM2 - The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TREM2. The invention also relates to multimeric binding complexes which comprise at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder mediated by TREM2. | 2022-09-22 |
20220296727 | Immunoconjugate - The present disclosure relates to an immunoconjugate including an antibody, or antigen binding fragment thereof, that specifically binds to CD300f, linked to at least one cytotoxic agent, and to compositions including the immunoconjugate, and use of the immunoconjugate for depleting haematopoietic stem and progenitor cells, for preparing a subject haematopoietic stem cell transplantation, and for the treatment of CD300f associated conditions. | 2022-09-22 |
20220296728 | ROOM TEMPERATURE STABLE, SINGLE SHOT mRNA VACCINE FOR COVID-19 - This disclosed technology relates to a new mRNA COVID-19 vaccine that is stable at room temperature, requires only one injection, and is less prone to patient hypersensitivity reactions. The vaccine is practical to deploy globally during vaccination campaigns for current and future coronavirus pandemics and other infectious diseases. The disclosed technology is a method and system for producing the vaccine, and also a double-encapsulated mRNA vaccine product. The method uses double nanoencapsulation of an mRNA vaccine, first in phospholipid nanosomes and then in biodegradable polymer nanospheres. The method may be carried out as a continuous flow, integral, or two-stage processes. The method and system use supercritical fluid technology for nanoencapsulating mRNA in a solvent free process that minimizes loss of potency and preserves antigenicity of the nanoencapsulated mRNA and eliminates residual organic solvents in the final product. The double-encapsulated mRNA vaccine product is stable at room temperature and can be administered in a single shot to humans. | 2022-09-22 |
20220296729 | METHODS OF DOSING CIRCULAR POLYRIBONUCLEOTIDES - This invention relates generally to methods of dosing pharmaceutical compositions and preparations of circular polyribonucleotides thereof. | 2022-09-22 |
20220296730 | FOAMABLE COMPOSITION FOR USE IN SURGICAL DIAGNOSTIC PROCEDURES - Provided herein are foamable compositions comprising (1) a base, in aqueous suspension, (2) a viscosity modifier component, and (3) a surfactant component. In preferred embodiments, the foamable composition may further comprise a salt. Additional components that may optionally be present in the formable composition include sugars and sugar alcohols, colorants, antioxidants, preservatives, and other excipients generally known to those skilled in the art. Also provided herein are kits for producing a gaseous form. Also provided herein are methods for detecting the presence of leaks or defects in anatomical tissue or organ. | 2022-09-22 |
20220296731 | NANOEMULSION WITH PORPHYRIN SHELL - There is described herein a nanoparticle comprising an outer shell comprising a porphyrin salt, an expanded porphyrin salt or an analog of porphyrin salt, around an inner oil core. | 2022-09-22 |
20220296732 | NANOPARTICLE-ALGINATE GELS FOR X-RAY IMAGING OF THE VASCULATURE - Disclosed are capped nanoparticles that are effectively trapped within an aqueous gelling solution to produce stable gels and function as a contrast agent for vascular imaging. The contrast agent has good radioopacity, is inexpensive to produce, and is safe to handle. This provides a new method to image the fine vasculature of biological systems. | 2022-09-22 |
20220296733 | LIPID MICROBUBBLES AND PROCESS OF MAKING THEREOF - Disclosed is a suspension of gas-filled microbubbles in a physiologically acceptable liquid carrier comprising a lipid mixture of a first lipid having transition temperature of about 41° C. such as DPPC or DPPG, a second lipid having transition temperature of about 55° C. such as DSPC or DSPG, and a PEGylated DSPE such as DSPE-PEG2000, DSPE-PEG3000, or DSPE-PEG5000, and methods of preparation thereof. | 2022-09-22 |
20220296734 | RADIOPHARMACEUTICAL COMPOSITIONS OF RADIOACTIVE HALOGENATED BENZYLGUANIDINE - The present disclosure concerns radiopharmaceutical compositions of radioactive halogenated benzylguanidine (such as radioiodinated MIBG) or a pharmaceutically acceptable salt, hydrate, or solvate thereof. In a preferred embodiment, the composition has at least 97% of radiochemical purity for at least 4 days. Advantageously, the compositions of the present disclosure may be devoid of parabens, which are carcinogenic and yet are used in known radioactive MIBG compositions. The present disclosure also provides processes of preparing a radioactive halogenated benzylguanidine composition. The compositions of the present disclosure can be used in diagnosis and treatment of various diseases. | 2022-09-22 |
20220296735 | KIT FOR RADIOLABELLING WITH 68GA COMPRISING A METAL INHIBITOR - The present invention relates to a kit for radiolabelling a targeting agent with gallium-68. The present invention also relates to the use of said kit for radiolabelling a targeting agent, a method for radiolabelling a targeting agent with gallium-68 using said kit, said kit and a method of preparation. | 2022-09-22 |
20220296736 | ADMINISTRATION OF THERAPEUTIC AGENTS TO BRAIN AND OTHER CELLS AND TISSUE - Methods are provided for administering and/or assessing a therapeutic agent intraarterially across disrupted blood-brain barrier, systemically or directly to the brain parenchyma in a subject. In a particular aspect, drug infusion parameters can be adjusted based on feedback from real-time MRI and quantitative assessment of brain uptake of the infused therapeutic molecules based on PET imaging. | 2022-09-22 |
20220296737 | IMMUNOPET AND IMMUNOSPECT IMAGING TO IDENTIFY CYTOTOXIC T CELL ACTIVITY - Provided herein is a method for identifying cytotoxic T cell activity due to cancer immunotherapy in a subject. In some embodiments, the method comprises administering an effective amount of a tracer for positron emission tomography (PET) or single photon emission computed tomography (SPECT) to a subject receiving a cancer immunotherapy, wherein the tracer comprises an antibody or antigen-binding fragment thereof that specifically binds to a luminal domain of a lymphocytic granule-associated molecule (LGAM) labeled with a PET or SPECT detectable moiety, and detecting the signal of the tracer by PET or SPECT imaging to identify the cytotoxic T cell activity due to immune therapy for the cancer in the subject. In several embodiments, the antibody or antigen binding fragment specifically binds to the luminal domain of CD107a. | 2022-09-22 |
20220296738 | CUSTOM BRACHYTHERAPY CARRIERS - A carrier having one or more non-planar surfaces may be embedded with one or more radioactive seeds. A spherical carrier may be substantially radially symmetrical around an axis or a spherical carrier may include a non-spherical portion, such as a tapered portion that extends from a spherical portion. | 2022-09-22 |
20220296739 | METHOD OF STERILIZING LIQUID EJECTION HEAD, AND LIQUID EJECTION HEAD ASSEMBLY - A liquid ejection head to be sterilized includes: an ejection element substrate with an ejection port surface in which an ejection port for ejecting a liquid is formed; and a liquid storage part that stores the liquid to be supplied to the ejection port. A method of sterilizing the liquid ejection head includes: covering at least the ejection port surface with a protection member in a non-contact manner; making a liquid ejection head assembly by housing the protection member and the liquid ejection head or covering the protection member's opening portion with a sheet member that is vapor permeable at least at one portion so as to block entry of bacteria into the liquid ejection head; and performing vapor sterilization on the assembly. | 2022-09-22 |
20220296740 | SANITIZATION SYSTEMS AND METHODS FOR MEDICAL DEVICES - Systems and methods for sanitizing medical devices are provided. A system includes a container having a sanitization chamber, and the sanitization chamber is configured to receive a liquid and a medical device. A cover is configured to be supported by the container and obscure the sanitization chamber. The cover and the container are configured to be positioned in a microwave and facilitate converting the liquid to steam upon receipt of microwave energy from the microwave, and the steam sanitizes the medical device. A dryer rack is coupled to the cover, and the dryer rack is configured to support and thereby facilitates drying the medical device. | 2022-09-22 |
20220296741 | Sterilization Enclosure For Surgical Instruments - A sterilization enclosure to be placed within a sterilizer, the sterilization enclosure defining an interior for accommodating at least one surgical instrument and maintaining sterility of the at least one surgical instrument after the sterilization enclosure is removed from the sterilizer. The enclosure comprising a light source and a transparent window. The light source to illuminate the interior and the transparent window positioned such that the interior and the at least one surgical instrument are visible through the transparent window. A process indicator that is either disposed within the interior or coupled to an external surface of the sterilization enclosure. The process indicator in fluid communication with the interior of the sterilization enclosure such that the process indicator is exposed to a sterilant agent disposed within the interior of the sterilization enclosure to measure a characteristic within the interior during a sterilization process. | 2022-09-22 |
20220296742 | ANTIBACTERIAL INTERIOR COMPONENTS AND METHODS FOR USE THEREOF - An antibacterial interior component, such as a door handle component, is provided in a vehicle that includes at least one touch surface in a confined space having a shadowed region. A light source includes a light emitting diode (LED) that generates light having a wavelength of ≥about 375 nm to ≤about 425 nm directed towards the at least one touch surface for killing bacteria. A thermally conductive component in heat transfer relationship with the light source to transfer heat to a heat sink either in or adjacent to the antibacterial interior component. Methods of operating the self-sanitizing antibacterial interior component are also provided. | 2022-09-22 |
20220296743 | IMAGE FORMING APPARATUS - According to an embodiment, an image forming apparatus supplies, in a normal mode, electric power to an image forming device, and limits, in a power saving mode, power supplying to the image forming device to be less than that in the normal mode. The image forming apparatus communicates, in the normal mode, with a germicidal lamp apparatus via a communication interface such that the germicidal lamp apparatus generates no germicidal light, and communicates, in the power saving mode, with the germicidal lamp apparatus via the communication interface such that the germicidal lamp apparatus generates germicidal light. | 2022-09-22 |
20220296744 | Disinfectant Light Autonomous Robot Apparatus - A disinfectant light autonomous robot apparatus for sanitizing rooms with ultraviolet light includes a body having a body top side, a body bottom side, and a body perimeter. The body bottom side has a plurality of wheel cavities. A plurality of wheels is coupled within the plurality of wheel cavities. A drive motor is coupled within the body and is in operational communication with the plurality of wheels. A central processing unit is in operational communication with the drive motor. A plurality of sensors allows for automated maneuvering of the apparatus throughout a room. A battery is coupled within the body and is in operational communication with the central processing unit. An arm is pivotably coupled to the body top side and a plurality of ultraviolet lights is coupled to the arm. A touchscreen is coupled to the body to program the apparatus. | 2022-09-22 |
20220296745 | ANTIMICROBIAL SYSTEM WITH DISTRIBUTED USER AUTHENTICATED DISINFECTION CONTROLS AND AUTHENTICATED SAFE LOCKOUT PROTOCOL - Antimicrobial system including a luminaire configured to emit a disinfection light in an ultraviolet band for disinfecting a vicinity of a target pathogen. A switching device that includes a primary relay pack. A control station, an arming switch, a room sensor, and a security challenge device. The security challenge device has a communication interface, an operator interface to receive a security challenge input from an operator, a processor, and security challenge device programming in a memory. Execution of the security challenge device programming by processor configures the security challenge device to perform the following functions. Receive the security challenge input from the operator via the operator interface. In response to receiving the security challenge input, generate a security challenge response signal. Send, via the communication interface, the security challenge response signal to enable the primary relay pack to control power to the luminaire to emit the disinfection light. | 2022-09-22 |
20220296746 | ANTIMICROBIAL SYSTEM WITH DISTRIBUTED DISINFECTION CONTROLS AND ENHANCED SWITCHING DEVICE - Antimicrobial system including a luminaire configured to emit a disinfection light in an ultraviolet band for disinfecting a vicinity of a target pathogen. A switching device that includes a primary relay pack. The primary relay pack has a communication interface, a measurement circuit, a processor, and disinfection monitoring programming in a memory. Execution of the disinfection monitoring programming by the processor configures the primary relay pack to perform the following functions. Based on a second input from the operator, produce a visual inspection signal. Monitor, via the measurement circuit, a power parameter of the luminaire. Compare the monitored power parameter with an active disinfection threshold, a passive operation threshold, or a combination thereof. In response to the comparison, either determine that the disinfection light source is unexpectedly on, is degraded or disabled, or the luminaire is inoperable; or control power to the luminaire to emit the disinfection light. | 2022-09-22 |
20220296747 | AN ULTRASOUND TRANSDUCER DISINFECTING METHOD, DEVICE AND ELECTRONIC APPARATUS CAPABLE OF MONITORING HEAT - There is disclosed a method of performing high-level disinfection of medical instruments comprising: providing a disinfecting enclosure for receiving the medical instrument to be disinfected; actuating the disinfecting enclosure to apply disinfecting irradiation from a plurality of UVC LEDs mounted on an inner surface of the disinfecting enclosure to a surface of the medical instrument; sensing one or more temperature conditions within the disinfecting an enclosure during disinfecting irradiation; and processing the sensed temperature conditions to monitor a state of the disinfecting an enclosure. | 2022-09-22 |
20220296748 | ELECTRICAL HOUSEHOLD APPLIANCE AND ADDITIONAL ELECTROPASTEURIZER AND ELECTROSTERILIZER MODULE FOR FOOD AND UTENSILS - An electrical household appliance can electro pasteurize and electro sterilize food, clothes and similar utensils, through the synergy and harmonization of electric fields, magnetic fields and condensed electromagnetic waves. The appliance thereby allows modern homes to have a functional tool capable of supporting health more efficiently in their everyday environment, achieved through technology that also provides the ability to electro sterilize and electro pasteurize food while preserving the organoleptic properties thereof, and making it possible, in addition to sanitizing food prior to ingestion, to preserve the food in a specific module, which can be an additional module on the common refrigerator. The appliance can be applied to electro sterilizing and electro pasteurizing foods, utensils, linen and relevant objects relating to everyday domestic use. | 2022-09-22 |
20220296749 | SCISSORS HOLDER HAVING STERILIZATION FUNCTION - Disclosed herein is a scissors holder having a sterilization function. The scissors holder includes a loading part including a plurality of holding holes having a width larger than that of the blades of scissors and smaller than that of the handles of the scissors so that the scissors can be held therein in such a manner that the blades of the scissors enter thereinto and the handles of the scissors are supported thereon, a support part disposed on both lateral sides of the loading part so that the loading part can be disposed to be spaced apart from the ground or a surface of a piece of furniture by a predetermined distance, an internal space defined by the bottom of the loading part and the support part, and a sterilization part configured to sterilize the blades of scissors held in the internal space. | 2022-09-22 |
20220296750 | CHEMICAL-FREE DRY HEAT AND UVC DECONTAMINATION UNIT AND METHOD - A decontamination unit includes a housing having an internal cavity for containing an object that is to be decontaminated, a heater that is configured to heat the internal cavity and object, and at least one light source configured to supply ultraviolet light, such as UVC, to the internal cavity to irradiate the object. A decontamination cycle may perform the heat cycle and/or the UV cycle, which may be performed simultaneously during at least a part of the cycle to enhance the effectiveness in decontaminating the object. | 2022-09-22 |
20220296751 | PLASMA TREATMENT - A plasma treatment apparatus, comprising a housing defining a void ( | 2022-09-22 |
20220296752 | Full Coverage Disinfectant Spray Apparatus - A full coverage disinfectant spray apparatus for disinfecting a room includes a canister having a canister bottom side, a canister sidewall, and a canister top side. The canister contains a pressurized disinfectant sanitizer. A release tube is coupled to the canister. The release tube is coupled to the canister top side. A valve collar is coupled to the release tube. The valve collar selectively releases the pressurized disinfectant sanitizer through the release tube when depressed. A spray head is coupled to the valve collar. The spray head has a head top side, a head bottom side, and a head perimeter. The head bottom side is coupled to the valve collar. A plurality of nozzles is coupled to the spray head. The plurality of nozzles is coupled to the head perimeter and is in fluid communication with the valve collar. | 2022-09-22 |
20220296753 | ANTIMICROBIAL SYSTEM WITH DISTRIBUTED DISINFECTION CONTROLS AND SAFE LOCKOUT PROTOCOL - Antimicrobial system that includes distributed disinfection programming that implements a safe lockout protocol. The safe lockout protocol includes in response to a control station producing an arming initiation signal that is ON based on a first input from an operator, tracking a visual inspection signal produced by an arming switch based on a second input. The safe lockout protocol further includes in response to determining that the tracked visual inspection signal is ON and the control station producing an arming completion signal that is ON based on a third input, receiving a disinfection commencement signal that is ON based on a fourth input from the control station. The safe lockout protocol further includes in response to receiving the disinfection commencement signal that is ON based on the fourth input from the control station, controlling power to a luminaire to emit a disinfection light via a primary relay pack regulator. | 2022-09-22 |
20220296754 | Folding UV Array - An end effector of a robotic device is disclosed. The end effector includes a plurality of array segments, a plurality of UV light modules, and a first articulating member. Each array segment of the plurality of array segments is coupled to at least one other array segment of the plurality of array segments. Moreover, each UV light module is coupled to a different array segment of the plurality of array segments. The first articulating member is configured to cause at least one of the plurality of array segments to move relative to at least one other array segment. | 2022-09-22 |
20220296755 | SYSTEM FOR CASH DISINFECTION BY APPLYING CONTROLLED DOSES OF ULTRAVIOLET LIGHT AND METHODS OF DISINFECTION VERIFICATION THEREOF - An apparatus includes a bill feeder, a housing for holding a bill that is received from the bill feeder, sensors coupled to the housing, an ultraviolet (UV) lamp that emits ultraviolet light to illuminate a portion of the bill, a UV shutter to control a power of the ultraviolet light on the bill, a memory and a processor. The processor configured to determine at a property of the bill from a first output of a first sensor, to determine a bill contaminant on the bill from a second output from a second sensor, to retrieve a UV dose rate to be applied by the ultraviolet light needed to sterilize the bill based on the type of bill contaminant on the bill, the property of the bill, an illumination area or any combination thereof, and to apply the UV dose rate to the bill. | 2022-09-22 |
20220296756 | SENSOR-HEATING ELEMENT CONFIGURATIONS AND MULTI-LOOP CONTROL CYCLES FOR DRY-HEAT STERILIZERS - Methods and systems implement a dry-heat sterilizer configured to operate at temperatures permissive of a heat-intolerant articles and heat-intolerant packaging. To effectively and evenly transmit heat throughout a dry-heat sterilizer at such temperatures, the dry-heat sterilizer furthermore provides an electronic controller coupled to multiple sensor-heating element configurations, the electronic controller configured to compute proportional-integral-derivative (PID) terms to operate a multi-loop heat control cycle including at least a first feedback loop and a second feedback loop, and configured as an asymptotic PID controller for at least one feedback loop. In this fashion, the likelihood that spot airflow temperature at particular temperature sensors will overshoot a PID setpoint is substantially reduced. This results in spot airflow temperature at the temperature sensors being sustained at the PID setpoint asymptotically, substantially improving precision of heat control cycles. | 2022-09-22 |
20220296757 | Sterilization Container Capable Of Providing An Indication Regarding Whether Or Not Surgical Instruments Sterilized In The Container Were Properly Sterilized - A sterilization system comprising a sterilization container for holding a surgical instrument, the sterilization container formed to allow sterilant to enter and residual sterilant to exit so that the surgical instrument in the sterilization container can be subjected to a sterilization process. The sterilization container comprises an electronic sensor module for measuring a characteristic of an environment in the sterilization container during a sterilization process. The system further comprises a station capable of being in electronic communication with the sterilization container, with the station comprising a station memory. The station is configured to track usage of the sterilization container on the station memory based on data measured by the electronic sensor module. | 2022-09-22 |
20220296758 | CHEMICAL-FREE MOIST HEAT DECONTAMINATION UNIT AND METHOD - A decontamination unit includes a housing having an internal cavity for containing a contaminated object that is to be decontaminated, a heater in thermal communication with the internal cavity and is configured to heat the internal cavity and object, and a humidity generator in fluid communication with the internal cavity and configured to supply humidity to the internal cavity. A controller is configured to control a temperature and a relative humidity within the internal cavity according to a decontamination cycle for decontaminating the object. The decontamination cycle may be preset based on the object(s) and/or type of contaminant. According to one aspect, the decontamination cycle is performed with at least the parameters of a temperature in a range from 170° F. to 200° F., a relative humidity in a range from 50% to 80%, and a time in a range from 15 minutes to 60 minutes. | 2022-09-22 |
20220296759 | Sterilization Validation System and Method - A sterilization validation system and method are disclosed that ensure sterilization of packaging materials that contain certain sterilized items that have been sterilized in a cleanroom environment. In accordance with the disclosed subject matter, garments (or other items or materials) that are sterilized inside autoclave or breather bags may be secured within tote liners that ensure sterility of the exterior of the breather bags containing the garments. Not only is it possible to ensure a recipient that the garment is sterile, but it is also possible to verify that the outside of the breather bag itself is also sterile, since the breather bag will remain sterilized inside the tote liner during shipping. | 2022-09-22 |
20220296760 | ELECTRONIC SCENT PRODUCING IMITATION CANDLE DEVICE - Electronic imitation candle devices are described that produce a scent while including a flame-like element that simulates a real fire flame. One example device includes a support assembly having a base, a top plate and a support rod that connects the base and the top plate, as well as a flame element and a light source to simulate a real candle flame. The device also includes a fragrance compartment above the top plate that includes a lid removably positioned on top of the fragrance container. The device is further provided with a heating element above the top plate and below the fragrance container to provide heat to the fragrance container, and a switch coupled to the lid of the fragrance container and operable to sense that the fragrance container is covered by the lid and to deactivate the heating element when the fragrance container is covered by the lid. | 2022-09-22 |
20220296761 | SYSTEMS AND METHODS FOR GENERATING SCENTS - A method of generating scents, the method including receiving, by a processor, an instruction to generate a first scent, and heating, responsive to the instruction to generate the first scent, a first scented material. | 2022-09-22 |
20220296762 | BACTERICIDE DIFFUSION APPARATUS AND BACTERICIDE DIFFUSION METHOD - There are provided a bactericide diffusion apparatus and a bactericide diffusion method that have excellent design and make it possible to stably diffuse a bactericide. A bactericide diffusion apparatus includes: a bactericide containing chlorine dioxide; a first container housing the bactericide and having a first opening; and a second container housing the first container, having a second opening and being made of a ceramic. The first container includes a first portion defining the first opening, a second portion located below the first portion and having a diameter larger than that of the first opening, and a third portion located below the second portion and having a diameter larger than that of the second portion. The second container includes a main body portion housing the first container and having the second opening, and a lid portion fitted to the second opening. The lid portion has a hole for diffusing chlorine dioxide. | 2022-09-22 |
20220296763 | Personal Reusable Microdiffuser - A small, reusable scent emitting device (FIG. | 2022-09-22 |
20220296764 | ANTIMICROBIAL SYSTEM WITH DISTRIBUTED DISINFECTION CONTROLS, INTEGRATED ARMING SWITCH SENSORS, AND STREAMLINED SAFE LOCKOUT PROTOCOL - Antimicrobial system including a luminaire configured to emit a disinfection light in an ultraviolet band for disinfecting a vicinity of a target pathogen. A switching device that includes a primary relay pack. A control station, an integrated arming switch, a room sensor. The integrated arming switch has a communication interface, an integrated room sensor, a processor, and integrated arming switch programming in a memory. Execution of the integrated arming switch programming by processor configures the integrated arming switch to perform the following functions. Based on a second input from the operator, produce a visual inspection signal. In response to the integrated room sensor detecting occupancy of the vicinity of the physical space by the human, produce a room state signal. Send, via the communication interface, the visual inspection signal to enable the primary relay pack to control power to the luminaire to emit the disinfection light. | 2022-09-22 |
20220296765 | Photocatalytic Odor Control and Destruction Device - A photocatalytic odor control device includes an air passageway defined between an air inlet and an air outlet and configured to conduct and direct air flow, a photocatalytic plate disposed within the air passageway, the photocatalytic plate having a titanium dioxide coating incorporating metal oxide ion dopants on the surface of the plate, and a light source configured to emit an ultraviolet light onto the photocatalytic plate, the emitted ultraviolet light having a predetermined wavelength sufficient to trigger a photocatalytic reaction to generate hydroxyl free radicals and reactive oxygen species to neutralize organic compounds in the air flow. | 2022-09-22 |
20220296766 | PHOTOCATALYTIC FACIAL MASK AND METHOD FOR MANUFACTURING THE SAME - In a photocatalytic facial mask and a method for manufacturing the photocatalytic facial mask, the facial mask includes an inner layer, an outer layer, and a functional filter layer. The functional filter layer is disposed between the inner layer and the outer layer. The functional filter layer includes a photoactive layer, the photoactive layer includes a photocatalytic fiber having a core-shell structure, and the core-shell structure includes a core having a polymer fiber and a shell having a photocatalyst disposed at the core. | 2022-09-22 |
20220296767 | SUPERABSORBENT MATERIAL ABSORBENT CAPACITY INCREASE WITH USE OF MULTIFUNCTIONAL CHEMICAL AGENTS - The present invention discloses a method for increasing absorbent capacity of a superabsorbent material (SAM) by treating the SAM with a selected multifunctional chemical agent (MCA) or a combination of a plurality of selected MCAs. The selected MCA(s) may interact with the polymer chain of the SAM through one or a plurality of mechanisms that enhance the absorbent capacity of the SAM. In various preferred embodiments, SAMs include polyelectrolytes that are made from polymerizing mixtures of acrylic acid monomer and acrylic acid sodium salt, and L-arginine or lysine is selected as the MCA. | 2022-09-22 |
20220296768 | ABSORBENT ARTICLE WITH PLANT PROTEIN BASED ABSORBENT MATERIAL - An absorbent article for absorption of body fluids, including an absorbent member that includes at least one plant protein based absorbent material obtainable by a method including the steps of i. providing a mixture or suspension including a liquid and a plant protein, wherein the plant protein is insoluble in the liquid, ii. acylating the plant protein by adding an acylating agent thereto, and iii. obtaining the plant protein based absorbent material. | 2022-09-22 |
20220296769 | COMPOSITION FOR DELIVERING NITRIC OXIDE TO SKIN - A skin application composition comprising a first component comprising S-nitrosothiol in dry inactive condition is provided. | 2022-09-22 |
20220296770 | Dressing With Epithelialization And Scar Reduction Feature - Provided are systems, dressings, and methods suitable for treating a tissue site, such as an incision or linear wound, for example. The systems, dressings, and methods relate to a dressing assembly that may include a dressing bolster, a comfort layer, and a polymeric enhancement layer. The dressing bolster may include foam and may have a first side and a second side. A first side of the comfort layer may be coupled to the second side of the dressing bolster, and a first side of the polymeric enhancement layer may be coupled to the second side of the comfort layer. An opposing second side of the polymeric enhancement layer may be configured to directly contact the tissue site. Other systems, dressings, apparatuses, and methods are disclosed. | 2022-09-22 |
20220296771 | ELECTROACTIVE BIOADHESIVE COMPOSITIONS - Electrochemically initiated bioadhesive compositions comprising biocompatible polymers containing derivatives of diazonium, arylsulfonium, or diaryliodonium in general, and to their use in tissue fixation, in particular. | 2022-09-22 |
20220296772 | NOVEL GLUE FOR EMBOLIZATION OF LYMPHATIC LEAKAGE - A novel glue for embolization of lymphatic leakage. An optimized lymphatic embolization agent (LEA) as described herein comprises a NAM hydrogel and tantalum at a mixture of at or about 1:3 tantalum to NAM hydrogel, wherein said LEA is radiopaque. | 2022-09-22 |
20220296773 | USE OF IGSF10 IN PREPARATION OF BONE TISSUE REGENERATION PRODUCT - The present disclosure relates to the field of medicines, in particular to the use of IGSF10 in the preparation of a bone tissue regeneration product, especially the use of IGSF10 in combination with BMP in the preparation of a product for promoting bone tissue regeneration. The product includes a periodontal bone defect repair product, a jaw bone defect repair product and/or a skull defect repair product. The new use of IGSF10 of the present disclosure can reduce the effective concentration of BMP without obvious adverse reactions, thereby exploring a method to promote bone tissue regeneration and providing new ideas for the treatment of bone defects. | 2022-09-22 |
20220296774 | SUPRAMOLECULAR STRUCTURES - The present invention relates to a supramolecular structure comprising a plurality of fused fibrils wherein each fibril comprises a plurality of cell adhesion motif lipopeptides. The invention also relates to an aqueous medium comprising said structure, a surface for cell maintenance, cell culture and/or cell bioprocessing wherein immobilised in or on the surface is said structure, as well as uses of said structure in cell maintenance, cell culture and/or bioprocessing. | 2022-09-22 |
20220296775 | HYBRID ANNULOPLASTY RING FOR TRICUSPID OR MITRAL VALVE REPAIR - An annuloplasty ring prosthesis comprising a frame having an outer surface; and a cover surrounding the frame. The cover comprises a bioprosthetic tissue that can be regenerative or fixed and non-regenerative. The frame can be bioabsorbable or non-degradable. A ring prosthesis and a method of manufacturing a ring prosthesis is also provided. The ring prosthesis comprising an elongated rod member formed into a substantially ring shape, the elongated rod member being formed substantially from a flat bioprosthetic tissue. | 2022-09-22 |
20220296776 | Extracellular Matrix for Treating Pelvic Floor Disorders and Skeletal Muscle Degeneration - Described herein are compositions comprising decellularized extracellular matrix derived from skeletal muscle or other suitable tissue, and therapeutic uses thereof. Methods for treating, repairing or regenerating defective, diseased, damage, ischemic, ulcer cells, tissues or organs in a subject preferably a human, with diseases associated with muscular degeneration, using a decellularized extracellular matrix of the invention are provided. Methods of preparing culture surfaces and culturing cells with absorbed decellularized extracellular matrix are provided. | 2022-09-22 |
20220296777 | HIGH-DENSITY MICROCHANNELS - Provided herein are scaffold biomaterials including at least one bundle of microchannels, the bundle of microchannels having a plurality of decellularised microchannels isolated from plant or fungal tissue, the decellularised microchannels being arranged substantially parallel to each other within the bundle. Also provided are methods and uses of such scaffold biomaterials and bundles, as well as methods for the production of such scaffold biomaterials and bundles. | 2022-09-22 |
20220296778 | ALLOGENEIC MICROVASCULAR TISSUE FOR SOFT TISSUE TREATMENTS - Disclosed are products and methods for treating soft tissue injuries. The provided methods include the production of processed or cryopreserved microvascular tissue. Also provided are products and methods of using processed or cryopreserved microvascular tissue for the treatment of soft tissue injuries. | 2022-09-22 |
20220296779 | BIOPROSTHETIC TISSUE PREPARATION - Methods for preparing bioprosthetic tissue are provided. In some instances, bioprosthetic tissue is treated to remove antigenic biomolecules. In some instances, prepared bioprosthetic tissues are incorporated into a medical device. | 2022-09-22 |
20220296780 | BIOCERAMIC-CONTAINING THERMOPLASTIC EXTRUSION AND METHOD OF SURGICAL IMPLANT MANUFACTURE - A method of generating a bioceramic-containing biomaterial-derived thermoplastic extrusion is provided. The method includes combining a bioceramic-containing solid with at least one thermoplastic resin, wherein the bioceramic-containing solid is uniformly dispersed in the resin. The method further includes extruding the bioceramic-containing solid included in the resin to create a net shape. The net shape is selected from a group consisting of a filament, a pellet, a bar, a molding, and a three-dimensional printing material stock. | 2022-09-22 |
20220296781 | Injectable Temperature-sensitive Composite Hydrogel Containing Adipose-derived Mesenchymal Stem Cells and Preparation Method and Application Thereof - The present application provides an injectable temperature-sensitive composite hydrogel containing adipose-derived mesenchymal stem cells, and a preparation method and application thereof. The present application includes: preparing hydroxypropyl chitin from chitin through modification, preparing a composite with collagen and sodium hyaluronic, constructing the injectable temperature-sensitive composite hydrogel, loading adipose-derived mesenchymal stem cells of New Zealand rabbit and Genipin, and finally forming in-situ the injectable temperature-sensitive composite hydrogel containing adipose-derived mesenchymal stem cells at the physiological temperature. The hydrogel prepared in the present application is of a three-dimensional porous structure, which is conducive to transferring of nutrients and metabolic waste, so as to provide an excellent microenvironment for the growth of cells, helping maintain survival rate and biological activity of the adipose-derived mesenchymal stem cells, and promoting differentiation of the adipose-derived mesenchymal stem cells into cartilage tissue, while having high mechanical strength, and thus can be widely used in cartilage tissue engineering. | 2022-09-22 |
20220296782 | GENERATING ENDOTHELIAL CELL-SEEDED VASCULAR GRAFTS - Provided herein are human arterial endothelial cell-seeded polymeric vascular grafts suitable for replacing or bypassing natural blood vessels and exhibiting increased long term patency rates and reduced leukocyte adhesion relative to grafts comprising venous endothelial cells. Methods for generating the human arterial endothelial cell-seeded vascular grafts and therapeutic uses of the same are also described. | 2022-09-22 |
20220296783 | COMPOSITE BIOMATERIALS - Provided herein are composite scaffold biomaterials including two or more scaffold biomaterial subunits, each including a decellularized plant or fungal tissue from which cellular materials and nucleic acids of the tissue are removed, the decellularized plant or fungal tissue having a | 2022-09-22 |
20220296784 | METHOD FOR OBTAINING HEALTHY INTESTINAL ORGANOIDS - The present invention is related to a biofunctional three-dimensional hydrogel suitable for the expansion of freshly isolated or frozen intestinal cells and the formation of intestinal organoids therefrom, that avoids the use of a naturally-derived matrix such as Matrigel and provides intestinal organoids suitable for clinical applications and generated in a commercially feasible manner. The present invention is also related to a kit of parts comprising said hydrogel in combination with a suitable culture medium, and to a method of making organoids and expanding cells from freshly isolated or frozen intestinal cells with said kit of parts. | 2022-09-22 |
20220296785 | DEGRADABLE REGENERATIVE MEDICAL MATERIAL FOR PROMOTING TISSUE IN-SITU REGENERATION AND PREPARATION METHOD THEREFOR - A degradable regenerative medical material for promoting tissue in-situ regeneration and a preparation method therefor. The degradable regenerative medicine material is formed by means of chemically bonding Si, P, O and metallic elements containing calcium, and is a regular three-dimensional net structure the material of which having a nano-scale mesoporous structure is framework, and pores and micron-scale macropores that communicate with the pores are uniformly distributed in the regular three-dimensional net structure. The preparation method for the degradable regenerative medical material comprises the steps of mixing a sol, foaming, curing and calcining. The degradable regenerative medicine material has a huge specific surface area, powerful biological activity and high biological safety, has the effect of promoting cell proliferation, may induce the rapid regeneration of its own damaged tissue cells, and achieve an in-situ tissue repair function. | 2022-09-22 |
20220296786 | FORMULATIONS AND PROCESSES TO GENERATE REPELLENT SURFACES ON MEDICAL DEVICES - Formulations for preparing repellent coatings on surfaces of substrates, such as medical devices, can include a non-cyclic volatile siloxane solvent such as a linear or a branched volatile alkyl (e.g., methyl) siloxane solvent and mixtures thereof. Such formulations include (i) one or more reactive components that can form a bonded layer on a surface in which the bonded layer comprises an array of compounds having one end bound to a surface and an opposite end extending away from the surface; (ii) an acid catalyst; and (iii) the non-cyclic volatile siloxane solvent. The formulation can also include (iv) a lubricant. | 2022-09-22 |
20220296787 | ANTIMICROBIAL BODY ACCESS SYSTEM - An antimicrobial catheter includes an elongated body adapted to be inserted into a body cavity of a patient that is not vascular or the urethra. An antimicrobial surface is positioned along an exterior circumferential surface of the elongated body, wherein the antimicrobial surface is configured to inhibit pathogens. The elongated body has at least one interior lumen defined by a sidewall forming the elongated body. The exterior circumferential surface extends between a first end of the elongated body and a second end of the elongated body. | 2022-09-22 |
20220296788 | INJECTABLE BIOPOLYMER COMPOSITIONS AND ASSOCIATED SYSTEMS AND METHODS - Injectable biopolymer compositions and associated systems and methods are disclosed herein. In some embodiments, a biopolymer composition for treating an aneurysm is provided. The biopolymer composition can include an injectable hydrogel including: a biopolymer; a chemical crosslinker forming covalent bonds with the biopolymer; and a stabilizer configured to inhibit ex vivo precipitation of the biopolymer. The injectable hydrogel can have an ex vivo storage modulus of at least 100 Pa at 37° C. over a linear viscoelastic region of the injectable hydrogel. The ex vivo storage modulus can be greater than an ex vivo loss modulus of the injectable hydrogel over the linear viscoelastic region of the injectable hydrogel. | 2022-09-22 |