38th week of 2010 patent applcation highlights part 50 |
Patent application number | Title | Published |
20100240864 | METHOD FOR CHANGING THE PREDEFINED MEAN MOLECULAR WEIGHT MN DURING THE CONTINUOUS PRODUCTION OF POLYTETRAHYDROFURANES OR THE COPOLYMERS - The present invention provides a process for changing the given mean molecular weight M | 2010-09-23 |
20100240865 | PROCESS FOR PRODUCTION OF CYCLIC PEPTIDES - The invention relates to methods for the preparation of polypeptides. The polypeptides are prepared in high purity of at least about 98.5%, and preferably at least about 99% by HPLC. | 2010-09-23 |
20100240866 | MODIFIED GHERLIN PEPTIDES - The present invention provides a novel peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof. | 2010-09-23 |
20100240867 | FLUORENE COMPOUND - Particular compounds having a fluorene skeleton are superior in broad utility and stability, as a protecting reagent for liquid phase synthesis of amino acids and/or peptides. | 2010-09-23 |
20100240868 | Composition and Method for a Producing Stable Amyloid Beta Oligomers of High Molecular Weight - The invention relates to a method for the preparation of a stable, soluble amyloid beta (Aβ) oligomer and composition thereof for use as an antigen for the generation of antibodies for the treatment of Alzheimer's disease and other conditions related to abnormal amyloid beta aggregation. The method which uses a pH in excess of 7.0 and high concentrations of Aβ, optionally includes the use of divalent anions or a helix-inducing solvent to form the oligomers. The stable, soluble Aβ oligomers produced by the method herein have a particle size of 10 to 100 nm in diameter, when measured by a dynamic light scattering technique, and a molecular weight of 100 to 500 kDa. | 2010-09-23 |
20100240869 | GENE RELATED TO GROWTH PROMOTING FUNCTION OF ACETIC ACID BACTERIUM, ACETIC ACID BACTERIUM BRED USING THE GENE AND METHOD FOR PRODUCING VINEGAR USING THE ACETIC ACID BACTERIUM - The present invention is to obtain a novel gene that encodes a protein having a function of promoting acetic acid bacterial growth in the presence of a high concentration of acetic acid; to enhance acetic acid bacteria's function of promoting growth and thereby to develop acetic acid bacteria with an improved fermentation ability in the presence of a high concentration of acetic acid; and to provide a method for efficiently producing vinegar that contains a high concentration of acetic acid in a short time using the acetic acid bacterium. A novel gene having a function of improving the function of promoting growth at a practical level was cloned from acetic acid bacteria for practical use, belonging to the genus | 2010-09-23 |
20100240870 | Composite organic-inorganic nanoclusters - Composite organic-inorganic nanoclusters (COINs) are provided that produce surface-enhanced Raman signals (SERS) when excited by a laser. The nanoclusters include metal particles and a Raman-active organic compound. The metal required for achieving a suitable SERS signal is inherent in the nanocluster and a wide variety of Raman-active organic compounds and combinations thereof can be incorporated into the nanocluster. In addition, polymeric microspheres containing the nanoclusters and methods of making them are also provided. The nanoclusters and microspheres can be used, for example, in assays for multiplex detection of biological molecules. | 2010-09-23 |
20100240871 | Galactose Alpha(1-3) Galactose Compositions - An enzymatic method for synthesizing oligosaccharides comprising a terminal Gal-alpha(1,3)-Gal-beta(1-4)GlcNac is used to produce Fc-containing molecules with certain properties. The methods modify glycoproteins that interact with receptors or are processed in vivo and recognized as unique epitopes. In particular, the glycan groups on a therapeutic antibody capable of interaction with Fc-receptors are modified. | 2010-09-23 |
20100240872 | ANTI-Muc 17 ANTIBODY - An antibody that binds to Mucin17 (Muc17) is disclosed. The antibody of the present invention preferably binds to the peptide of SEQ ID NO:3 and does not bind to the peptide of SEQ ID NO:4 or the peptide of SEQ ID NO:5. Also disclosed are an anti-cancer agent, preferably an anti-cancer agent for pancreatic cancer, which comprises the antibody of the present invention, as well as a method of diagnosing cancer using the antibody of the present invention, preferably the antibody of the present invention that does not bind to the secreted-form of Muc17. | 2010-09-23 |
20100240873 | LIGAND (ACT-4-L) TO A RECEPTOR ON THE SURFACE OF ACTIVATED CD4+ TCELLS - The invention provides ligands and fragments thereof to a receptor on the surface of activated CD4 | 2010-09-23 |
20100240874 | METHOD FOR PURIFYING CANCER-SPECIFIC PROLIFERATING CELL NUCLEAR ANTIGEN - An isolated antibody that binds a cancer specific Proliferating Cell Nuclear Antigen (csPCNA) that binds to the amino acid sequence LeuLysGlnLeuAspAlaGlnGlnThrGlnLeuArgIle AspSerPhePheArgLeuAlaGlnGlnGluLysGluAspAlaLysArg (SEQ ID No. 1). An immunoassay that utilizes an isolated antibody that binds a form of csPCNA that binds to the SEQ ID No. 1 to identify the presence of csPCNA in a sample. | 2010-09-23 |
20100240875 | Antibodies That Specifically Bind to Reg IV - The present invention relates to antibodies and related molecules that specifically bind to Reg IV. Such antibodies have uses, for example, in the prevention and treatment of gastrointestinal tract cancers, inflammatory bowel disorders, and diabetes. The invention also relates to nucleic acid molecules encoding anti-Reg IV antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially gastrointestinal tract cancers, inflammatory bowel disorders, and diabetes, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to Reg IV. | 2010-09-23 |
20100240876 | REPLIKINS AND METHODS OF IDENTIFYING REPLIKIN-CONTAINING SEQUENCES - The present invention provides methods for identifying a class of peptides referred to as replikins and methods of using replikins to stimulate the immune system of a subject. The method of identifying replikin peptides is based on identifying amino acid sequences comprising 7 to about 50 amino acids that contain (1) at least one lysine residue located six to ten residues from a second lysine residue; (2) at least one histidine residue; and (3) at least 6% lysine residues. | 2010-09-23 |
20100240877 | Integrated system for producing value-added products from lignin produced in the manufacturing of cellulosic ethanol - A more efficient and economical production/processing/utilization system for managing waste lignin produced in the manufacturing of cellulosic ethanol. The process is also more environmentally sound as the multiple uses of a single feedstock on and off site result in a direct reduction of life cycle green house gas emissions. The resulting benefits of this type of co-location will also speed the commercialization for cellulosic bio fuel and help reduce our dependence on foreign oil. | 2010-09-23 |
20100240878 | Fluorescent saccharide conjugates - The present invention relates to improved fluorescently labeled monosaccharide and low molecular weight oligosaccharide conjugates for immunofluorescent staining, confocal microscopic imaging and flow cytometry/fluorescence activated cell sorting (FACS). These fluorophore conjugates target cells, components of cell surfaces and extracellular components; and are useful as probes for tumor targeting and cellular uptake. | 2010-09-23 |
20100240879 | PROCESSES FOR PREPARING OF GLUCOPYRANOSYL-SUBSTITUTED BENZYL-BENZENE DERIVATES AND INTERMEDIATES THEREIN - The present invention relates to processes for preparing the compounds of general formula I, | 2010-09-23 |
20100240880 | AB INITIO GENERATION OF SINGLE COPY GENOMIC PROBES - Single copy sequences suitable for use as DNA probes can be defined by computational analysis of genomic sequences. The present invention provides an ab initio method for identification of single copy sequences for use as probes which obviates the need to compare genomic sequences with existing catalogs of repetitive sequences. By dividing a target reference sequence into a series of shorter contiguous sequence windows and comparing these sequences with the reference genome sequence, one can identify single copy sequences in a genome. Probes can then be designed and produced from these single copy intervals. | 2010-09-23 |
20100240881 | THERAPEUTIC COMPOSITIONS - This application relates to therapeutic siRNA agents and methods of making and using the agents. | 2010-09-23 |
20100240882 | Apparatus, System and Method for Purifying Nucleic Acids - Methods and devices for isolating nucleic acids from a mixture containing such nucleic acids and extraneous matter are provided. In one embodiment, the method of the invention comprises passing the mixture through a glass frit under conditions effective to separate the nucleic acids from the extraneous matter. In a more specific embodiment, the glass frit is a sintered glass fit. | 2010-09-23 |
20100240883 | Lipid-drug conjugates for drug delivery - New prodrugs are derived from highly water soluble parent drugs that exist as primary or secondary amines in their parent form. Lipophilic carrier groups are bonded to the parent drug via an amide linkage with additional linker elements between the amide group and the carrier group. | 2010-09-23 |
20100240884 | Process for preparing randomly-bonded polysaccharides - The invention relates to a process for preparing a randomly-bonded polysaccharide, comprising as ingredients a saccharide, a polyol and an acid serving as a catalyst, the process comprising the steps of feeding the ingredients into a reactor in order to dehydrate the fed ingredients to an essentially anhydrous syrup, polycondensating the essentially anhydrous syrup at elevated temperatures in the said reactor while removing the reaction water, wherein the reactor is a mixing kneader device with counter-acting blades, wherein during the feeding step the saccharide, the polyol and the acid serving as catalyst are simultaneously or consecutively fed to the reactor, and in that during the dehydratation and polycondensation step the free water and reaction water is removed from the mixing kneader device by kneading and mixing the fed ingredients and the subsequent essentially anhydrous syrup under reduced pressure in the reactor, and during the polycondensation the essentially anhydrous syrup is continuously kneaded in the kneader reactor until the required degree of polymerisation is obtained. | 2010-09-23 |
20100240885 | METHOD OF MANUFACTURING PHTHALOCYANINE COMPOUND - Provided is a method of manufacturing a phthalocyanine compound denoted by general formula (3). The method comprises conducting a reaction of a compound denoted by general formula (1) or (2) with a metal and/or metal compound in a solvent in the presence of a secondary amine and/or diamine to obtain the phthalocyanine compound denoted by general formula (3). | 2010-09-23 |
20100240886 | PROCESS FOR PRODUCING CARBAPENEM COMPOUND - The present invention has its object to provide an easy process for producing (4R,5S,6S)-3-[[(3S,5S)-5-(dimethylaminocarbonyl)-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, excellent in antimicrobial activity. The present invention relates to a process for continuously producing (4R,5S,6S)-3-[[(3S,5S)-5-(dimethylaminocarbonyl)-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid without isolating/purifying the reaction intermediate. | 2010-09-23 |
20100240887 | New methods of producing HHT - A safe pharmaceutical composition for treatment of cancer contains Homoharringtonine (HHT). The new methods of process for producing HHT include culture plant tissue and semisynthesis. | 2010-09-23 |
20100240888 | SALTS OF BAZEDOXIFENE - The invention deals with new crystalline salts of bazedoxifene, by means of which a high API quality can be achieved in a high yield. | 2010-09-23 |
20100240889 | Urea Derivatives Methods For Their Manufacture And Uses Thereof - The present invention provides compounds of formula (I): in which R | 2010-09-23 |
20100240890 | Novel benzamidine derivatives, process for the preparation thereof and pharmaceutical composition comprising the same - The present invention relates to novel benzamidine derivatives, process for the preparation thereof and pharmaceutical composition comprising the same. The novel benzamidine derivatives of the present invention are useful for the prevention and treatment of osteoporosis, bone fractures and allergic inflammatory diseases. | 2010-09-23 |
20100240891 | DRUG CONTAINING BENZOPHENONE DERIVATIVE OR ITS SALT - Pharmaceutical agents characterized by containing benzophenone derivatives represented by the general formula: | 2010-09-23 |
20100240892 | ELECTROLUMINESCENT DEVICE - Disclosed are electroluminescent devices that comprise organic layers that contain certain organic compounds containing one ore more pyrimidine moieties. The organic compounds containing one ore more pyrimidine moieties are suitable components of blue-emitting, durable, organo-electroluminescent layers. The electroluminescent devices may be employed for full color display panels in for example mobile phones, televisions and personal computer screens. | 2010-09-23 |
20100240893 | NITROGENOUS HETEROCYCLIC COMPOUNDS AND PROCESS FOR MAKING NITROGENOUS HETEROCYCLIC COMPOUNDS AND INTERMEDIATES THEREOF - The present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof and a process for making thereof. The compounds have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention also provides intermediate compounds useful in the process, as well as final products produced by the process, and salts or prodrugs thereof. The invention further provides a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases comprising administering an effective amount of a compound according to the invention to a patient in need thereof. | 2010-09-23 |
20100240894 | METHOD FOR PRODUCING AMINES FROM GLYCERIN - The present invention relates to a process for preparing amines by reacting glycerol with hydrogen and an aminating agent from the group of ammonia and primary and secondary amines in the presence of a catalyst at a temperature of from 100° C. to 400° C. and a pressure of from 0.01 to 40 MPa (from 0.1 to 400 bar). Preference is given to using glycerol based on renewable raw materials. The catalyst preferably comprises one metal or a plurality of metals or one or more oxygen compounds of the metals of groups 8 and/or 9 and/or 10 and/or 11 of the Periodic Table of the Elements. The invention further relates to the use of the reaction products as an additive in cement or concrete production and in other fields of use. This invention further provides the compounds 1,2,3-triaminopropane, 2-aminomethyl-6-methylpiperazine, 2,5-bis(aminomethyl)piperazine and 2,6-bis(aminomethyl)piperazine. | 2010-09-23 |
20100240895 | LIGHT-EMITTING MATERIAL COMPRISING ORTHOMETALATED IRIDIUM COMPLEX, LIGHT-EMITTING DEVICE, HIGH EFFICIENCY RED LIGHT-EMITTING DEVICE, AND NOVEL IRIDIUM COMPLEX - A compound represented by following formula (24): | 2010-09-23 |
20100240896 | METHOD FOR HYDROFORMYLATION - The present invention relates to a process for the hydroformylation of compounds of the formula (I), | 2010-09-23 |
20100240897 | Spirocyclic Cyclohexane Compounds - Spirocyclic cyclohexane compounds corresponding to formula I | 2010-09-23 |
20100240898 | CHIRAL PHOSPHORUS COMPOUND - The present invention relates to novel chiral phosphorus compounds which can be readily prepared from quinoline derivatives as inexpensive starting compounds and have the general formula (I) wherein R | 2010-09-23 |
20100240899 | INTERMEDIATE RELEASE NICOTINIC ACID COMPOSITIONS FOR TREATING HYPERLIPIDEMIA WHICH EXHIBIT AN IN VIVO STAIR-STEPPED ABSORPTION CURVE - Intermediate release nicotinic acid formulations exhibiting an in vivo stair-stepped or sigmoidally-shaped absorption curves when the plasma nicotinic acid or nicotinuric acid curves are deconvoluted using the Wagner-Nelson method, which are suitable for oral administration once-a-day preferably during the evening or at night for treating hyperlipidemia without causing drug-induced hepatotoxicity to such a level that requires the therapy to be discontinued, are disclosed. The stair-stepped or sigmoidal-shaped absorption profiles for nicotinic acid or nicotinuric acid absorbed from the nicotinic acid formulations of the instant invention are characterized by three phases and by the fact that significant quantities of nicotinic acid are absorbed during the first two phases. The first phase generally ends at about 2.3 hours following ingestion and the second phase generally ends at about 7.3 hours after consumption. Approximately 6% of the nicotinic acid dose is generally absorbed by the end of the first phase and approximately 91% of the nicotinic acid dose is absorbed by the end of the second phase. | 2010-09-23 |
20100240900 | DISPERSIBLE CARBON NANOSPHERES AND METHODS FOR MAKING SAME - The carbon nanomaterials and methods relate to methods for causing carbon nanospheres to be readily dispersible in a material. The carbon nanospheres are rendered dispersible using a cationic surfactant. The surfactant includes one or more cationic group that can bond to the surface of the carbon nanospheres, without detrimentally affecting the unique properties of carbon nanospheres. The dispersible carbon nanospheres can be dried (i.e., solvent is driven off) while maintaining their dispersibility in solvents and other materials. | 2010-09-23 |
20100240901 | LIGHT EMITTING DEVICE INCLUDING SEMICONDUCTOR NANOCRYSTALS - A light emitting device includes a semiconductor nanocrystal in a layer. The layer can be a non-polymeric layer. | 2010-09-23 |
20100240902 | Oxadiazole Derivative, Light-Emitting Element Material, Light-Emitting Element, Light-Emitting Device, and Electronic Device - An object is to provide a novel material having a bipolar property. Another object is to provide an oxadiazole derivative having a wide band gap. Another object is to reduce power consumption of a light-emitting element, a light-emitting device, and an electronic device. The present invention provides an oxadiazole derivative represented by General Formula (1). In the formula, Ar | 2010-09-23 |
20100240903 | CRYSTALLINE TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS - The invention relates to crystalline tripeptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions. | 2010-09-23 |
20100240904 | PROCESSES FOR THE PREPARATION OF N-(2-ACETYL-4,6-DIMETHYLPHENYL)-3--2-THIOPHENECARBOXAMIDE - Provided are processes for the preparation of N-(2-acetyl-4,6-dimethylphenyl)-3-{[(3,4 dimethyl-5-isoxazolyl)amino]sulfonyl}-2-thiophenecarboxamide, a compound useful for the treatment of endothelin-mediated disorders. | 2010-09-23 |
20100240905 | Novel Curcumin and Tetrahydrocurcumin Derivatives - The invention relates to novel curcumin and tetrahydrocurcumin derivatives, which have been modified at one phenolic group to incorporate more-reactive groups. The curcumin and tetrahydrocurcumin derivatives are in the form of monomers, dimmers, and polymers. | 2010-09-23 |
20100240906 | 1-PHENYL-1H-PYRAZOLE-BASED COMPOUNDS - Methods useful for preparing compounds of formula I: | 2010-09-23 |
20100240907 | PROCESSES FOR THE PREPARATION OF PYRAZOLES - The present invention relates to novel processes for the production of compounds of formula (I) wherein Hal and Hal′ are independently selected from Cl and F, and R | 2010-09-23 |
20100240908 | ACETYLENE COMPOUND - The invention provides an acetylene compound represented by the following Formula (1), which is useful as a raw material for a polymer achieving high thermal resistance; | 2010-09-23 |
20100240909 | PROCESS FOR THE PREPARATION OF STABLE NITROXYL RADICALS - Process for the preparation of stable nitroxyl radicals (I) starting from N-benzylphthalimide in two steps. In the first step, the intermediate N-benzyl-1,1,3,3-tetra-alkylisoindoline is prepared by treatment with a Grignard reagent, prepared in methyl-tert-butyl ether, of N-benzylphthalimide, obtained in the same reaction environment starting from phthalic anhydride and benzylamine. In the second step, the N-benzyl-1,1,3,3-tetra-alkylisoindoline is transformed into the nitroxyl radical by hydrogenolysis and subsequent oxidation with hydrogen peroxide in the presence of a catalyst selected from acids and salts of polymolybdic or polytungstic acids. | 2010-09-23 |
20100240910 | POLYHETEROCYCLIC COMPOUND, ORGANIC ELECTRONIC DEVICE USING POLYHETEROCYCLIC COMPOUND, AND ELECTRONIC APPARATUS INCLUDING ORGANIC ELECTRONIC DEVICE - Disclosed is a novel polyheterocyclic compound, an organic electronic device using the polyheterocyclic compound, and an electronic apparatus including the organic electronic device. The polyheterocyclic compound has excellent solubility to solvent and high charge mobility. The organic electronic device produced by using the polyheterocyclic compound has excellent performance and is easily produced. | 2010-09-23 |
20100240911 | Process for the preparation of N-monosubstituted beta-amino alcohols - A process for the preparation of a compound of formula: | 2010-09-23 |
20100240912 | METHOD FOR PRODUCING CARBONATE COMPOUND - The present invention is to provide a production process capable of selectively producing various kinds of fluorine-containing carbonate compounds without any inhibition in high yields without using phosgene and without producing hydrogen chloride as a by-product. The present invention relates to a process for producing a fluorine-containing compound having a carbonate bond by reacting a compound (1) with a fluorine-containing compound having an OH group. In the formula (1) shown below, X | 2010-09-23 |
20100240913 | PROCESS FOR PREPARING EPSILON-CAPROLACTONE - The present invention provides a process for preparing ε-caprolactone in a purity of more than 99% by cyclizing 6-hydroxycaproic esters in the liquid phase at from 150 to 400° C. and from 1 to 1020 hPa abs., and removing and condensing the compounds which are volatile under cyclization conditions, which comprises thermally treating the remaining bottom product of the cyclization in at least one further reactor, removing and condensing volatile compounds and obtaining ε-caprolactone by distillation from the condensates. | 2010-09-23 |
20100240914 | Radical polymerizable macrocyclic resin compositions with low polymerization stress - A composition of macrocyclic oligomer with at least one polymerizable group, (meth)acrylate, for example. | 2010-09-23 |
20100240915 | Pre-Treatment of Crude Alcohol or Furan Feed to a Vapor Permeation Apparatus - We disclose a method of extracting an alcohol or furan from a predominantly liquid stream comprising the alcohol or furan, comprising removing cations from the predominantly liquid stream comprising the alcohol or furan, using a cation-exchange resin; removing anions from the predominantly liquid stream comprising the alcohol or furan, using an anion-exchange resin; and recovering alcohol or furan from the predominantly liquid stream comprising the alcohol or furan, using either a vapor permeation membrane, a perevaporation process, or both. | 2010-09-23 |
20100240916 | PROCESS FOR OBTAINING STEROIDAL PHOSPHATE COMPOUNDS - A process for obtaining 21-disodium phosphate pregnane derivative compounds of formula (I), wherein X═R═H or X═F and R=α-CH | 2010-09-23 |
20100240917 | Enzymatic oil recuperation process - A process for the recuperation of acylglycerols or acylglycerols containing free fatty acids from gums, present as aqueous emulsions, said gums being obtained by subjecting triglyceride oil to one or more degumming processes, said recuperation process comprising the steps of: subjecting said gums to enzymatic hydrolysis catalysed by one or more enzymes with phospholipase activity; allowing said gums to separate into two or more phases, said two or more phases including at least an oily phase and an aqueous phase; and recuperating said oily phase comprising acylglycerols or acylglycerols containing free fatty acids; wherein said enzymatic hydrolysis is accelerated by adding at least part of the one or more enzymes with phospholipase activity to at least part of the water used in the recuperation and/or at least one degumming process; and/or at least part of said triglyceride oils treated in said degumming process; and/or by facilitating mixing at least part of said one or more enzymes with phospholipase activity into said gums by increasing the triglyceride oil content of said gums; and an oil obtained by this process. | 2010-09-23 |
20100240918 | TANTALUM AMIDO-COMPLEXES WITH CHELATE LIGANDS USEFUL FOR CVD AND ALD OF TaN AND Ta205 THIN FILMS - Tantalum compounds of Formula I hereof are disclosed, having utility as precursors for forming tantalum-containing films such as barrier layers. The tantalum compounds of Formula I may be deposited by CVD or ALD for forming semiconductor device structures including a dielectric layer, a barrier layer on the dielectric layer, and a copper metallization on the barrier layer, wherein the barrier layer includes a Ta-containing layer and sufficient carbon so that the Ta-containing layer is amorphous. According to one embodiment, the semiconductor device structure is fabricated by depositing the Ta-containing barrier layer, via CVD or ALD, from a precursor including the tantalum compound of Formula I hereof at a temperature below about 400° C. in a reducing or inert atmosphere, e.g., a gas or plasma optionally containing a reducing agent. | 2010-09-23 |
20100240919 | Process For Obtaining Valine Derivatives Useful For Obtaining A Pharmaceutically Active Compound - The invention provides a method for obtaining the intermediate (II), useful for manufacturing Valsartan and a drug directed to a treatment of arterial hypertension or heart failure. The process comprises a) Imination of the aldehyde group of a compound (VII) by L-Valine (IV) salts with organic or inorganic bases and a polar solvent or water, where X means halogen or an —OSO2R group, where R is CF3, tolyl, methyl or F; to give an imine-type compound (VIII), where B+ is the protonated form of an organic base or an alkaline cation; b) Reduction of the imine group of the compound (VIII) followed by acidification, to give the compound (VI); and c) N-Acylation of the compound (VI) with valeryl chloride to give the compound (II). Steps a) and b) can be performed in a “one pot” reaction. | 2010-09-23 |
20100240920 | PHOSPHATE SURFACTANTS - A compound of Formula 1 | 2010-09-23 |
20100240921 | Catalyst for Oxidation or Ammoxidation, and Process for Producing the Same - It is an object to provide a novel oxide catalyst for producing an unsaturated acid or unsaturated nitrile by which reaction results are good and a high yield can be stably maintained for a prolonged period of time, a process for producing the oxide catalyst, and a process for producing an unsaturated acid or unsaturated nitrile using the oxide catalyst. According to the present invention, there is provided an oxide catalyst represented by following compositional formula (1): | 2010-09-23 |
20100240922 | Sidewall-functionalized carbon nanotubes, and methods for making the same - The invention provides a method of functionalizing the sidewalls of a plurality of carbon nanotubes with oxygen moieties, the method comprising: exposing a carbon nanotube dispersion to an ozone/oxygen mixture to form a plurality of ozonized carbon nanotubes; and contacting the plurality of ozonized carbon nanotubes with a cleaving agent to form a plurality of sidewall-functionalized carbon nanotubes. | 2010-09-23 |
20100240923 | ENZYMATIC SYNTHESIS OF (METH)ACRYLIC ESTERS OF HYDROXY-FUNCTIONAL AROMAS - A process for preparing (meth)acrylic esters (F) of hydroxy-functional aromas (A), in which at least one hydroxy-functional aroma (A) in the presence of at least one enzyme (E) is esterified with (meth)acrylic acid (S), or transesterified with at least one (meth)acrylic ester (D), the reaction in the case of the transesterification being effected in the absence of solvents. | 2010-09-23 |
20100240924 | 2-ETHYL-4,6-DIMETHYL-PHENYL-SUBSTITUTED TETRAMIC ACID DERIVATIVES AS PEST CONTROL AGENTS AND/OR HERBICIDES - The invention relates to a novel 2-ethyl-4,6-dimethylphenyl-substituted tetramic acid derivatives of the formula (I) | 2010-09-23 |
20100240925 | METHODS FOR MAKING UNSATURATED ACIDS USING CATALYSTS FOR METHACROLEIN OXIDATION - Methods for making unsaturated acids using catalysts for oxidation of unsaturated and/or Saturated aldehyde to unsaturated acids is disclosed where the catalyst including at least molybdenum (Mo) and phosphorus (P), where the catalyst has a pore size distribution including at least 50% medium pores and if bismuth is present, a nitric acid to molybdenum mole ratio of at least 0.5:1 or at least 6.0:1 moles of HNO | 2010-09-23 |
20100240926 | PROCESS FOR PREPARING (R)-N-BENZYL-2-(BENYLOXYCARBONYLAMINO)-3-METHOXYPROPIONAMIDE - (R)—N-benzyl-2-(benzyloxycarbonylamino)-3-methoxypropionamide is an intermediate useful for preparing lacosamide. It can be prepared, for example, by combining (R)—N-benzyl-2-(benzyloxycarbonylamino)-3-hydroxypropionamide with dimethylsulfate, followed by mixing with an alkali or alkaline earth metal hydroxide at a temperature of about 25° C. to about −15° C. | 2010-09-23 |
20100240927 | METHOD FOR PREPARATION OF PARTICLES - The present invention relates to a new method for preparing micron-sized particles which comprises introducing in the particle formation vessel a solute solution in a solvent and a compressed fluid under supercritical conditions, wherein the vessel in which the particles are formed is at a pressure comprised between atmospheric pressure and 15 bar. The particles obtained present a small size, a limited size distribution, and low agglomeration. Particles with suitable fluidity can furthermore be prepared from products, for example, pharmaceutical active ingredients and/or excipients, with a low glass transition temperature. | 2010-09-23 |
20100240928 | PROCESS FOR THE PREPARATION OF (S)-2-AMINO-1-PROPANOL (L-ALANINOL) FROM (S)-1-METHOXY-2-PROPYLAMINE - The invention relates to a process for the preparation of (S)-2-amino-1-propanol (L-alaminol) from (S)-1-methoxy-2-propylamine via the hydrochloride of (S)-2-amino-1-propanol and subsequent work-up. | 2010-09-23 |
20100240929 | PROCESS FOR PREPARING POLYMERS OF POLYHYDRIC ALCOHOLS - The present invention relates to a process for accelerated preparation of linear polymers of polyhydric alcohols using microwave irradiation as the heat element in the presence of specified catalysts. | 2010-09-23 |
20100240930 | Process for the manufacture of polyol perfluoropolyether derivative - A process for the manufacture of a polyol (per)fluoropolyether derivative, comprising: 1. reacting at least one triol having two protected hydroxyl functions and a free hydroxyl group with an activating agent, to yield an activated protected triol; 2. reacting the activated protected triol with a functional (per)fluoropolyether derivative of formula: T | 2010-09-23 |
20100240931 | PROCESS FOR PRODUCTION OF DITRIMETHYLOLPROPANE - The present invention provides a method for producing ditrimethylolpropane including reacting n-butyraldehyde with formaldehyde in the presence of a base catalyst to thereby produce trimethylolpropane and ditrimethylolpropane, wherein the method includes (I) a step of reacting n-butyraldehyde with formaldehyde (1) in the presence of a base catalyst (1), to thereby produce a reaction mixture containing trimethylolpropane, ditrimethylolpropane, and 2-ethyl-2-propenal; (II) a step of recovering 2-ethyl-2-propenal through distillation of the produced reaction mixture; and (III) a step of adding, to a distillation residue obtained through recovery of 2-ethyl-2-propenal, the recovered 2-ethyl-2-propenal and formaldehyde (2), and optionally a base catalyst (2), to thereby allow reaction for production of ditrimethylolpropane to proceed, wherein the amounts of formaldehyde (I) and the base catalyst (1) supplied in step I and formaldehyde (2) and the base catalyst (2) supplied in step II are controlled to specific amounts, to thereby effectively produce ditrimethylolpropane. According to the present invention, the yield of di-TMP is considerably increased, and the amount of bis-TMP by-produced can be considerably reduced with respect to the amount of di-TMP (i.e., a product of interest) produced; that is, di-TMP can be effectively produced in an industrially advantageous manner. | 2010-09-23 |
20100240932 | Process for preparing dimethyl ether - Disclosed is a process for preparing dimethyl ether, including a) reacting methanol containing 0-80 mol % of water in the presence of a dehydration catalyst, b) transferring the reaction product into a single separation column, thus separating dimethyl ether, water, and unreacted methanol, c) withdrawing dimethyl ether and withdrawing unreacted methanol from the sidestream of the single separation column, and d) recyling the unreacted methanol to the a) reacting the methanol. Dimethyl ether may be prepared from water-containing methanol, and the separation and withdrawal of dimethyl ether, water, and unreacted methanol may be realized using a single column, thus reducing the investment cost and the operating cost. | 2010-09-23 |
20100240933 | Lutein Extraction from Ozone-Treated Plant Sources - The use of ozonation has been discovered to increase the lutein extraction from aflatoxin-free corn and for some batches of alfalfa. In addition, the ozonation will substantially decrease any aflatoxin in the plant source. The structure of lutein as indicated by HPLC elution profile and the function of lutein using an antimutagenic activity was shown not to be affected by the ozonation. | 2010-09-23 |
20100240934 | METHOD FOR PRODUCING 1,2-PROPANDIOL BY HYDROGENATING GLYCERINE IN A TWO-STEP REACTOR CASCADE - The present invention relates to a process for preparing 1,2-propanediol, in which a glycerol-containing stream, especially a stream obtained on the industrial scale in the production of biodiesel, is subjected to a hydrogenation in a two-stage reactor cascade. | 2010-09-23 |
20100240935 | Use of Isotopic Analysis for Determination of Aromatic Hydrocarbons Produced From Methane - Benzene and xylene are described having a unique distribution of deuterium and | 2010-09-23 |
20100240936 | CATALYSTS AND PROCESSES FOR SELECTIVE HYDROGENATION OF ACETYLENE AND DIENES IN LIGHT OLEFIN FEEDSTREAMS - A catalyst and a method for selective hydrogenation of acetylene and dienes in light olefin feedstreams are provided. The catalyst retains higher activity and selectivity after regeneration than conventional selective hydrogenation catalysts. The catalyst contains a first component and a second component supported on an inorganic support. The inorganic support contains at least one salt or oxide of zirconium, a lanthanide, or an alkaline earth. | 2010-09-23 |
20100240937 | PROCESS FOR THE PRODUCTION OF OLEFINS - Disclosed is a process for the production of C2 to C3 olefins via the catalytic cracking of feedstocks including C4 and heavier olefins in an integrated reaction/regeneration system. | 2010-09-23 |
20100240938 | PROCESS FOR PRODUCING TRIPTANE - A process for producing triptane and/or triptene from methanol and/or one or more derivatives thereof, and optionally one or more further alcohols and/or derivatives thereof at a temperature in the range of from 150 to 400° C., in the presence of a zeolite catalyst having Brønsted acidity, in which all the carbon atoms in the triptane and/or triptene are derived from the methanol and/or one or more derivatives thereof and the optional further alcohols and/or derivatives thereof, the zeolite catalyst being selected from: i. zeolites having frameworks comprising silicon and aluminium atoms at a Si:Al mole ratio of greater than (2), which zeolites also have a channel structure comprising a ring size of (12) or more non-oxygen atoms in (2) or (3) dimensions; and ii. zeolites having frameworks comprising silicon and aluminium atoms, and which have a framework ring comprising (12) or more non-oxygen-atoms accessible on the external surface of the zeolite and a pore structure in which all of the channels have a ring-size of less than (12) non-oxygen atoms. There is also described a process for producing triptane and/or triptene wherein the zeolite catalyst is zeolite X, the reaction composition additionally comprises a C | 2010-09-23 |
20100240939 | Dehydration of 1- Phenyl Ethanol - A process for the production of styrene is described. The process comprises dehydrating 1-phenyl ethanol in the liquid phase in the presence of a para- and ortho-toluenesulfonic acid mixture. The ratio of para-toluenesulfonic acid to ortho-toluenesulfonic acid is from 1:9 to 20:1. The process results in reduced heavies production, improved 1-phenyl ethanol conversion and selectivity, less reactor tube fouling, and lower corrosion rates. | 2010-09-23 |
20100240940 | Method of providing heat for chemical conversion and a process and system employing the method for the production of olefin - A method and system for providing heat to a chemical conversion process is advantageously employed in the production of olefin by the catalytic dehydrogenation of a corresponding hydrocarbon. The catalytic dehydrogenation process employs diluent steam operating at a steam to oil ratio which can be 1.0 or below and relatively low steam superheater furnace temperature. The process and system are advantageously employed for the production of styrene by the catalytic dehydrogenation of ethylbenzene. | 2010-09-23 |
20100240941 | New Catalyst for Higher Production Rates in Hydrocarbon Dehydrogenation - A process is presented for the dehydrogenation of hydrocarbons in a radial flow reactor. The process includes the continuous feeding of catalyst into the reactor and the continuous withdrawal of catalyst from the reactor, where the catalyst is modified to increase the increased density. The catalyst is a layered structure with a dense core and an active catalytic outer layer. | 2010-09-23 |
20100240942 | PROCESS FOR HYDRODEOXYGENATION OF FEEDS DERIVED FROM RENEWABLE SOURCES WITH LIMITED DECARBOXYLATION CONVERSION USING A CATALYST BASED ON NICKEL AND MOLYBDENUM - The invention concerns a process for hydrodeoxygenation of feeds derived from renewable sources with conversion by decarboxylation/decarbonylation limited to at most 10%, using a bulk or supported catalyst comprising an active phase constituted by at least one element from group VIB and at least one element from group VIII, said elements being in the sulphide form, and the atomic ratio of the metal (or metals) from group VIII to the metal (or metals) from group VIB being strictly more than 0 and less than 0.095, said process being carried out at a temperature in the range 120° C. to 450° C., at a pressure in the range 1 MPa to 10 MPa, at an hourly space velocity in the range 0.1 h | 2010-09-23 |
20100240943 | DEGRADATION OF ORGANIC POLLUTANTS IN AN AQUEOUS ENVIRONMENT USING CORONA DISCHARGE - An electrode includes an elongated conductive metal support and a layer of carbon fibers supported by, and in electrical contact with, the elongated conductive metal support such that ends of fibers of the layer of carbon fibers extend beyond the conductive metal support. | 2010-09-23 |
20100240944 | BLOOD PUMP, MEDICAL APPARATUS HAVING A BLOOD PUMP AND METHOD FOR ASSISTING THE POSITIONING OF A BLOOD PUMP - The invention relates to a blood pump and a medical apparatus having a blood pump, which is provided for insertion into the heart of a patient. The blood pump has at least one imaging sensor disposed in the region of the distal end of the blood pump to obtain imaging information in a blood vessel or in the heart. The invention also relates to a method for assisting the positioning of a blood pump in the heart of a patient, wherein image information is recorded inside the body of the patient using the at least one imaging sensor of the blood pump and transmitted in real time to an image processing and playback facility disposed outside the body of the patient for display purposes. | 2010-09-23 |
20100240945 | RESPIRATORY BIOFEEDBACK DEVICES, SYSTEMS, AND METHODS - Respiratory-based biofeedback devices, systems, and methods are provided. A respiratory biofeedback method includes producing a respiratory signal in response to a user's respiratory activity, generating an audio output signal that includes a modified version of the respiratory signal, and converting the audio output signal into sound waves output to the user to provide biofeedback. The sound waves can be output to the user in real time response to the user's respiratory activity. A microphone can be used to generate the respiratory signal. The generated audio output signal can includes the respiratory signal modified to increase a volume level of a portion of the respiratory signal where the volume level exceeds a specified volume level. | 2010-09-23 |
20100240946 | Tissue Augmentation Material And Method - A permanent, biocompatible material for soft tissue augmentation. The biocompatible material comprises a matrix of smooth, round, finely divided, substantially spherical particles of a biocompatible ceramic material, close to or in contact with each other, which provide a scaffold or lattice for autogenous, three dimensional, randomly oriented, non-scar soft tissue growth at the augmentation site. The augmentation material can be homogeneously suspended in a biocompatible, resorbable lubricious gel carrier comprising a polysaccharide. This serves to improve the delivery of the augmentation material by injection to the tissue site where augmentation is desired. The augmentation material is especially suitable for urethral sphincter augmentation, for treatment of incontinence, for filling soft tissue voids, for creating soft tissue blebs, for the treatment of unilateral vocal cord paralysis, and for mammary implants. It can be injected intradermally, subcutaneously or can be implanted. | 2010-09-23 |
20100240947 | DEVICES FOR MINIMALLY INVASIVE PELVIC SURGERY - The invention, in various embodiments, provides systems, devices, and methods for treating urinary incontinence. | 2010-09-23 |
20100240948 | MALE URETHRAL PROSTHESIS WITH TENSIONING MEMBER - The present invention provides a urethral prosthesis including a first and a second arm that join to form a junction, and a stem that is also joined to the junction. The junction is adapted to exert sufficient pressure on a portion of a patient's urethra to prevent unintentional voiding of the patient's bladder. However, upon exerting a tension force on the stem, the pressure exerted by the junction is reduced such that the patient's bladder may be intentionally voided. | 2010-09-23 |
20100240949 | TRANSMEMBRANE SENSING DEVICE FOR SENSING BLADDER CONDITION - The disclosure describes a sensing device that is implantable to sense bladder conditions, as well as a neurostimulation system and method that make use of such a sensor for alleviation of urinary incontinence. The sensing device is implantable outside the bladder, but includes a lead that penetrates the bladder wall to deployed a sensor within the bladder. Using the sensor on the lead, the sensing device outside the bladder is able to detect a condition within the interior of the bladder. In this sense, the sensing device provides transmembrane sensing of internal bladder conditions. The condition may be indicative of bladder filling or bladder contraction, and may be used to control electrical stimulation applied to the patient to alleviate urinary incontinence. | 2010-09-23 |
20100240950 | Uretero-Renoscope - A uretero-renoscope includes a shaft, on whose distal end an instrument head is arranged. The instrument head tapers continuously in the distal direction. | 2010-09-23 |
20100240951 | Integrated Handle Assembly for Anchor Delivery System - Integrated systems and associated method for manipulating tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders or other purposes. In one aspect, the system includes a delivery device configured to deploy and implant anchor devices for such purposes. | 2010-09-23 |
20100240952 | ENDOSCOPY METHOD AND ENDOSCOPE - With an endoscope including a long, thin inserted portion that is inserted into the body of a patient, securing means for securing the inserted portion to tissue inside the body, the securing means being provided at least at a distal-end portion of the inserted portion, an observation optical system that is provided at the inserted portion and that acquires an image of the tissue, and observation-distance adjusting means for adjusting the distance between the observation optical system and a surface of the tissue, it is possible to attain a stable field of view without having to stop the pulsation or the like of the heart or other tissue. | 2010-09-23 |
20100240953 | ENDOSCOPE SYSTEM, ENDOSCOPE VIDEO PROCESSOR AND METHOD OF DRIVING ENDOSCOPE SYSTEM - A light source device emits normal illumination light and special illumination light interchangeably at a charge-storage time of an imaging device. A DRP is reconfigurable between a normal image producing circuit and a special image producing circuit. A CPU instructs the reconfiguration of the DRP when detecting that a vertical synchronization signal from a drive circuit falls to zero level. The DRP gains an access to a configuration memory to load circuit information of the normal or special image producing circuit. According to the circuit information loaded, the DRP changes functions and interconnection of processor elements. | 2010-09-23 |
20100240954 | MEDICAL DEVICE POSITIONING SYSTEM - Embodiments of the invention include a medical device for accessing a patient's body portion and used for diagnosis and treatment of medical conditions. Embodiments of the invention may include a particular endoscopic positioning mechanism for placing an endoscope and an additional treatment device within desired body portions in order to assist in diagnosis and treatment of anatomical diseases and disorders. In particular, a medical device according to an embodiment of the invention may include an outer flexible tube and a positioning mechanism configured for rotating one portion of the flexible tube relative to another portion of the flexible tube. | 2010-09-23 |
20100240955 | LUMEN PROBE APPARATUSES AND METHODS FOR USING THE SAME - A probe apparatus adapted for movement through a lumen, comprising: a linearly extendible and retractable element adapted for selective extension and retraction to provide the movement; a front balloon positioned forward of the linearly extendible and retractable element and adapted for selective inflation and deflation; a rear balloon positioned backward of the linearly extendible and retractable element and adapted for selective inflation and deflation; and, a twisting element adapted to twist at least one of the linearly extendible and retractable element, front balloon and rear balloon during inflation and deflation of the advancement balloon. | 2010-09-23 |
20100240956 | IRRIGATING BIOPSY INLET VALVE - A valve for use in irrigating, accessing and sealing the instrument channel of an endoscope is disclosed. The valve includes a body having a first end, a second end, and an outer circumferential surface. The second end is adapted for connection to an instrument channel inlet port. The outer circumferential surface may define a side entry port. The valve includes a flip cap having an aperture therethrough. The cap is removably insertable into the first end for providing sealable access to the internal passage. The valve may include a tube having an inlet end, an outlet end, and a check valve disposed at the inlet end. The outlet end is fixed to the side entry port. A fluid may be dispensed through the check valve to irrigate the instrument channel. The valve may include a seal curtain member for providing sealable access to the instrument channel. | 2010-09-23 |
20100240957 | ACCESS PORT INCLUDING CENTERING FEATURE - An access port includes a housing defining a longitudinal axis and having proximal and distal ends, and an interior wall defining a longitudinal opening adapted for passage of a surgical object, an object seal disposed in mechanical cooperation with the housing and being configured to create a substantially fluid-tight seal around a surgical object inserted through the object seal and a centering mechanism mounted to the housing. The centering mechanism includes at least one centering element extending at least in a general longitudinal direction within the longitudinal opening and a substantially annular ring mounted to the at least one centering element. The at least one centering element is positioned and dimensioned to engage the surgical object during passage of the object through the longitudinal opening and is capable of radial outward deflective movement relative to the longitudinal axis in response to an outward force exerted by the surgical object during eccentric manipulation of the surgical object. The annular ring is adapted for radial movement during corresponding radial movement of the at least one centering element upon eccentric manipulation of the surgical object, to thereby engage the interior wall and apply a generally inward force counteracting the outward force exerted by the surgical object tending to bias the surgical object toward a generally aligned position with respect to the longitudinal axis. | 2010-09-23 |
20100240958 | SURGICAL PORTAL APPARATUS INCLUDING MOVABLE HOUSING - A surgical portal apparatus includes a housing and a cannula member. The housing includes a seal mount and a flexible housing wall. The cannula member is connected to the housing and defines a longitudinal axis and passageway. The seal mount has an internal seal. The flexible housing wall is dimensioned to permit both axial and radial movement of the seal mount with respect to the longitudinal axis between a first position of the seal mount and a plurality of second positions of the seal mount. The seal mount may be biased by a biasing member toward the first position. In an embodiment, the biasing member is a spring that is engageable with the cannula member and the seal mount. | 2010-09-23 |
20100240959 | RETRACTOR AND SEALING SYSTEM FOR SURGICAL/NON-SURGICAL INSTRUMENTS - A universal retractor and sealing system used in conjunction with surgical instruments such as cannulas, endoscopes surgical or non-surgical instruments or other tools. The user manipulates the instrument so as to create a projecting surface located inside the cavity. An outward force applied to the instrument body seats the projecting surface against the inner wall of the cavity, which can be used to form at least a partial seal against fluid. With the projecting surface positioned against the cavity wall, the instrument can be manipulated so as to act as a retractor, expanding the workable area and/or the field of view as required. | 2010-09-23 |
20100240960 | FLEXIBLE PORT SEAL - A flexible port seal is provided for use in single incision surgery and includes an outer seal defining a bore extending from a proximal end of the outer seal to a distal end of the outer seal. A support plate is located within the bore of the outer seal and one or more throughports are attached to the support plate for receipt of a surgical instrument. The throughports form a fluid tight seal with cannulas and/or surgical instruments inserted through the throughports. The flexible port seal is formed of a compressible or flexible material to facilitate insertion through the single incision in the patient and allow for movement of the surgical instruments relative to the seal to independently orient each of the surgical instruments. | 2010-09-23 |
20100240961 | MINIMALLY INVASIVE SURGICAL RETRACTOR WITH AN EXPANDED FIELD OF VISION - A surgical retractor includes a first component and a second component. The first component includes a ring structure and a conical outer wall. The ring structure has a first opening and defines a first plane. The outer wall forms a second opening in communication with the first opening and extends below the ring structure at an acute angle with respect to the first plane. The second component includes a top structure and conical inner wall. The top structure has a third opening and defines a second plane. The inner wall forms a fourth opening in communication with the third opening and extends below the top structure at an acute angle with respect to the second plane. The top structure of the second component is disposed at least partially inside the ring structure of the first component such that the second component is rotatably adjustable with respect to the first component. | 2010-09-23 |
20100240962 | EATING UTENSIL TO MONITOR AND REGULATE DIETARY INTAKE - Dietary intake regulating devices that can assist a user in measuring his or her dietary intake and optionally his or her physical activity are disclosed. | 2010-09-23 |
20100240963 | SYSTEM AND METHOD FOR VERIFYING MEDICAL IMPAIRMENTS - The present invention provides a method of verifying a medical impairment, comprising receiving a medical diagnosis of an injury, the numeric permanent impairment rating resulting from an evaluation of a permanent impairment, and comparing that permanent impairment rating to a statistically evaluated probable impairment rating of the injury. Depending on the results of the comparison, the assessed impairment rating may be reevaluated, in some cases by a trained impairment evaluator, and others by an expert medical staff. | 2010-09-23 |