39th week of 2018 patent applcation highlights part 8 |
Patent application number | Title | Published |
20180271707 | PROCESS FOR NEUROPROTECTIVE THERAPY FOR GLAUCOMA - Providing neuroprotective therapy for glaucoma includes generating a micropulsed laser light beam having parameters and characteristics, including pulse length, power, and duty cycle, selected to create a therapeutic effect with no visible laser lesions or tissue damage to the retina. The laser light beam is applied to retinal and/or foveal tissue of an eye having glaucoma or a risk of glaucoma to create a therapeutic effect to the retinal and/or foveal tissue exposed to the laser light beam without destroying or permanently damaging the retinal and/or foveal tissue and improve function or condition of an optic nerve and/or retinal ganglion cells of the eye. | 2018-09-27 |
20180271708 | PATIENT INTERFACE FOR OPHTHALMOLOGIC DIAGNOSTIC AND INTERVENTIONAL PROCEDURES - An ophthalmic system may comprise an imaging device having a field of view oriented toward the eye of the patient; a patient interface housing defining a passage therethrough, having a distal end coupled to one or more seals configured to be directly engaged with one or more surfaces of the eye of the patient, and wherein the proximal end is configured to be coupled to the patient workstation such that at least a portion of the field of view of the imaging device passes through the passage; and two or more registration fiducials coupled to the patient interface housing in a predetermined geometric configuration relative to the patient interface housing within the field of view of the imaging device such that they may be imaged by the imaging device in reference to predetermined geometric markers on the eye of the patient which may also be imaged by the imaging device. | 2018-09-27 |
20180271709 | Illuminated Welding Helmet System - An illuminated welding helmet system for selectively illuminating a darkened area during welding operations includes a welding helmet that may be worn during welding and the welding helmet includes an auto lens. A light unit is coupled to the welding helmet and the light unit selectively emits light outwardly from the welding helmet thereby facilitating a darkened area to be visible. The light unit is in electrical communication with the auto lens. Moreover, the light unit is turned on when the auto lens does not detect light and the light unit is turned off when the auto lens detects light. | 2018-09-27 |
20180271710 | Wireless earpiece for tinnitus therapy - A wireless earpiece in embodiments of the present invention may have one or more of the following features: (a) a housing for fitting in an ear of a user, (b) a logic engine controlling functionality of the wireless earpiece, (c) a plurality of sensors reading user input from the user, and (d) a transceiver communicating with at least a wireless device, wherein the logic engine receives a selection of audio through the plurality of sensors, determines whether a tinnitus frequency associated with a user wearing the wireless earpiece is present in the audio, filters the tinnitus frequency from the audio to generate filtered audio, and plays the filtered audio to the user utilizing one or more speakers. | 2018-09-27 |
20180271711 | Nerve Stimulation System - A treatment system including one or more of a wound dressing having one or more of a substrate element, a dressing member disposed on the substrate element, an adhesive element disposed on the substrate element, and a tether connecting the wound dressing to a treatment device. | 2018-09-27 |
20180271712 | Skin Closure Systems and Devices of Improved Flexibility and Stretchability for Bendable Joints - A system or device for skin closure comprises an elastic flat flexible tape elongated along a longitudinal axis and having a lower side and an opposing upper side, said tape having a pressure sensitive adhesive on at least a portion of the lower side, said tape having a plurality of openings arranged side-by-side with spaces between said openings oriented across the longitudinal axis. | 2018-09-27 |
20180271713 | TRANSPORT METHOD AND TRANSPORT DEVICE OF SINGLE-CUT SHEET ASSOCIATED WITH ABSORBENT ARTICLE - A method of transporting single-cut sheets cut from a continuous sheet for absorbent articles includes transporting the sheets by bonding an upstream end of each sheet to an outer surface of a first rotating body by adhesive; and transporting the sheets by holding the sheets on an outer surface of a second rotating body rotating faster than the first body, the sheets being transported from the first body in a state in which the upstream end of each sheet is on the first body, a portion of each sheet on the second body sliding relative to the outer surface of the second body such that each sheet is transported at the peripheral speed of the first body, after the adhesive is separated and the upstream end moves to the second body, the second body transporting the sheets at the peripheral speed of the second body. | 2018-09-27 |
20180271714 | REMOTE MONITORING OF ABSORBENT ARTICLE - In one example, a sensor system of a patient monitoring system includes a voiding sensor that includes an electrical circuit configured to be transitioned from a first impedance state to a second impedance state in response to a voiding event in an absorbent region of an absorbent article worn by a patient. The sensor system also includes one or more processors configured to: determine, based on whether the impedance state of the electrical circuit is open or closed, that the voiding event has occurred; and generate, based at least in part on the occurrence of the voiding event, patient status data of the patient. The sensor system also includes a communication module configured to wirelessly transmit, via a relay module, the patient status data to a remote monitoring device that is distinct from the relay module. | 2018-09-27 |
20180271715 | ABSORBENT ARTICLE - A pant type disposable absorbent article including a front body panel, a back body panel positioned at a distance from said front body panel, and an absorbent member; the absorbent article having a longitudinal central axis X-X and a transverse central axis Y-Y; the front body panel being substantially rectangular, and having a waist edge, two side edges, and an inward edge including a crotch edge and leg opening edges on each side of the crotch edge, between the crotch edge and each side edge, the front body panel being at least partially elasticized, the back body panel having a waist edge, two side edges, a crotch edge, and leg opening edges on each side of the crotch edge, between the crotch edge and each side edge, wherein a distance from the crotch edge to the waist edge is greater than the length of the side edges. | 2018-09-27 |
20180271716 | ELASTOMERIC LAMINATE WITH SOFT NONCRIMPED SPUNBOND FIBER WEBS - An absorbent article includes a first waist region, a second waist region, and a crotch region disposed between the first and second waist regions. The article also includes a chassis having a topsheet, a backsheet, and an absorbent core disposed between the topsheet and backsheet; and an ear joined to the chassis. The ear includes a laminate formed from a first nonwoven and second nonwoven and an elastomeric material sandwiched between said first and second nonwovens. The laminate further includes a plurality of ultrasonic bonds; and the first nonwoven includes an exterior surface having an average TS750 value of 5 db V2rms or less. | 2018-09-27 |
20180271717 | CRIMPED FIBER SPUNBOND NONWOVEN WEBS / LAMINATES - An article includes a chassis having a topsheet, backsheet and an absorbent core disposed between the topsheet and backsheet; and an ear joined to the chassis. The ear includes a ring-rolled laminate having a first nonwoven web and an elastomeric film; wherein the first nonwoven web has a crimped spunbond fiber nonwoven web. | 2018-09-27 |
20180271718 | DISPOSABLE DIAPER - The present invention relates to a disposable diaper for absorbing and receiving excreted urine and feces, and provides a disposable diaper divided into a front surface part touching the wearer's abdomen, a rear surface part touching the wearer's back, and a gap part in which the front surface part and the rear surface part extend in the lengthwise direction so as to pass between the wearer's legs, the disposable diaper including: a base layer including an absorber at an upper end thereof in the lengthwise direction on the basis of the center of the gap part, and including first elastic members on both sides in the lengthwise direction so as to encompass the wearer's legs; a cover layer positioned at an upper end of the absorber so as to cover the absorber; and a skin contact layer positioned at an upper end of the base layer so as to cover the cover layer, having an inlet cutting part cut in a predetermined length such that urine and feces easily reach the cover layer or the absorber, and having second elastic members, which come into close contact with the bottom layer skin of the wearer's buttocks in the lengthwise direction on both sides and are spaced apart from the inlet cutting part at predetermined intervals. | 2018-09-27 |
20180271719 | ABSORBENT ARTICLE HAVING A MULTI-COMPONENT TOPSHEET AND LEG CUFFS - The present disclosure is directed, in part, to an absorbent article including a topsheet including a second substrate disposed at least partially intermediate a first discrete substrate and a third discrete substrate. The first discrete substrate opposes the third discrete substrate about a longitudinal axis of the topsheet. The first discrete substrate and the second discrete substrate are bonded in a first bonding zone about a longitudinal axis of the topsheet. The third discrete substrate and the second discrete substrate are bonded in a second bonding zone about a longitudinal axis of the topsheet. A pair of leg cuffs have free terminal edges and are joined to the topsheet and/or backsheet. The distance between the free terminal edges is not longer than the distance between an inner edge of the first bonding zone and an inner edge of the second bonding zone. | 2018-09-27 |
20180271720 | ABSORBENT BODY FOR ABSORBENT ARTICLE - An absorbent body for an absorbent article includes: an absorbent core comprising a polymer absorbing agent; and core wraps. The core wraps include: (i) a first hydrophilic fiber-containing layer that is adjacent to the absorbent core and contains first hydrophilic fibers having an average fiber length of 25 mm to 75 mm; (ii) a pulp fiber-containing layer that is adjacent to the first hydrophilic fiber-containing layer and contains pulp fibers and (iii) a second hydrophilic fiber-containing layer that is adjacent to the pulp fiber-containing layer and contains second hydrophilic fibers having an average fiber length of 25 mm to 75 mm. Some of the pulp fibers pass through the first hydrophilic fiber-containing layer and are in contact with the absorbent core. | 2018-09-27 |
20180271721 | Combination Catamenial Tampon and Wipe - A catamenial tampon product combines a catamenial tampon and a personal hygiene cleansing wipe in one convenient package. The personal hygiene cleansing wipe is contained in an individual sealed package. The catamenial tampon product includes a pouch that contains the catamenial tampon. In some embodiments, the personal hygiene cleansing wipe is also contained within the pouch. Some embodiments of the catamenial tampon product have an opening that is covered by an adhesive panel or a closure flap. | 2018-09-27 |
20180271722 | SYSTEM FOR SENSING VITAL SIGNS ASSOCIATED WITH THE USE OF DISPOSABLE ABSORBENT ARTICLES - The present invention protects a system for monitoring the vital signs of a user of a disposable absorbent article that comprises a sensor device, a bi-dimensional code and a receiver, such that the sensor device is placed in contact with the user and the system is triggered by the reading of the bi-dimensional code through the receiver, such that the bi-dimensional code is place inside the packaging or the disposable absorbent article. | 2018-09-27 |
20180271723 | HUMAN TRANSPORT DEVICE THAT FACILITATES DECONTAMINATION - A transport device for use throughout a process of decontaminating a person exposed to contaminates is disclosed. The transport device includes a flexible sheet of material sized and shaped to support a person in a lying down position. The flexible sheet includes a base section and opposite side wall sections. The base section supports the person and the opposite side wall are configured to resiliently deflect upward along opposite sides of the person. The transport device includes a securing strap connected to the opposite side wall sections and configured to deflect the opposite side wall sections to secure the person on the flexible sheet. The transport device includes a drain in the base section. The drain permits liquid used in the process of decontamination to pass through and out of the flexible sheet. The drain includes a plurality of drain openings spaced apart from each other and distributed over the base section. | 2018-09-27 |
20180271724 | MOTOR VEHICLE WITH A MOBILE VEHICLE SEAT - The disclosure concerns a motor vehicle with a mobile vehicle seat. The seat includes a frame that forms a seating surface and a backrest. An energy source is arranged in the frame. A drive motor is arranged in the frame and connected to the energy source. At least one wheel is arranged on the frame and in drive connection with the drive motor. A control device controls the drive motor, and a first coupling is arranged on the frame to releasably fix the frame to the motor vehicle. A second coupling corresponding to the first coupling of the vehicle seat is arranged on an inside of a vehicle door, which is mounted pivotably on a vehicle superstructure. The second coupling can be brought into releasable engagement with the first coupling of the vehicle seat. | 2018-09-27 |
20180271725 | ELECTRICALLY POWER ASSISTED WHEELCHAIR AND METHOD OF CONTROLLING ELECTRICALLY POWER ASSISTED WHEELCHAIR - An electrically power assisted wheelchair includes a hand rim, a wheel that is rotated by receiving a torque applied to the hand rim, and a drive controller configured or programmed to apply auxiliary power to the wheel based on the torque applied to the hand rim. The drive controller is configured or programmed to decelerate rotation of the wheel when the wheel is rotating and no torque is applied to the hand rim in a brake mode in which a brake torque acting in a direction reverse to a rotation direction of the wheel is applied to the wheel. | 2018-09-27 |
20180271726 | MANUAL ELECTRIC FOLDING SCOOTER - A manual electric folding scooter belongs to the technical field of medical instruments comprises a folding assembly, a push rod shaft and a rotating spindle arranged in turn, one end of an electric push rod is fixed in the push rod shaft, and the other end of the electric push rod is driven by a motor; the folding assembly comprises a hook shaft with both ends welded to a fixing plate, two reinforcing rods are symmetrically welded in the middle of the hook shaft, and the free ends of the reinforcing rods after passing through the symmetrically arranged fixing plate are arranged in sliding slots of frame fixing pieces on corresponding sides. | 2018-09-27 |
20180271727 | LIFT CHAIR AND METHOD FOR LIFTING A SEAT THEREOF - A lift chair is provided, including a base, a seat, and a driving mechanism connected to the base and the seat. The driving mechanism can drive the seat to move relative to the base between a first position and a second position. When the seat is in the first position, a first distance is formed between the seat and the base. When the seat is in the second position, a second distance exceeding the first distance is formed between the seat and the base. When the seat is in the second position, the driving mechanism can drive the seat to rotate relative to the base. | 2018-09-27 |
20180271728 | Patient Stand Assist and Therapy Devices and Methods - A method of rehabilitating a person using a person lift device, includes the steps of: calculating a first amount of assistance provided by the person lift device to assist a person in moving between a first position and a second position at a first time; comparing the first amount of assistance to a previously determined amount of assistance; and providing a second amount of assistance as a function of the difference between the first amount of assistance and the previous amount of assistance to assist a person in moving between the first position and the second position at a second time. | 2018-09-27 |
20180271729 | PATIENT BED HAVING TRANSLATABLE SIDERAIL FOR BED EXIT - A number of patient beds are disclosed. Some patient beds have siderails that are movable by a patient so that the patient can egress from the bed without interference from the siderails. Various caregiver control panels and patient control panels for controlling features and functions of a patient bed are also disclosed. For example, a cart with caregiver control inputs, including hand inputs on a graphical user interface (GUI) and foot inputs, is disclosed. Patient positioning and transfer devices are also disclosed. Various types of in-bed physical therapy devices are also disclosed. | 2018-09-27 |
20180271730 | PERSON SUPPORT APPARATUS WITH ACTUATOR BRAKE CONTROL - A person support apparatus includes one or more motorized actuators that are braked in different manners depending upon whether or not electrical power is available to the control system. When electrical power is not available, a delay circuit delays closing a first switch that, when closed, short circuits the terminals of one of the motors. When power is available, other switches are opened and closed in a manner that short circuits the terminals of the motor while the first switch remains open. The other switches may be part of an H-bridge. The control system may also detect back emf (electromotive force) generated by the motor when electrical power is available and issue a notification to a technician or other user if an amplitude and/or duration of the detected back emf exceeds a threshold. | 2018-09-27 |
20180271731 | BED LIFTING FRAME - A bed lifting frame for motorized height adjustment of a lying surface includes a head unit, a foot unit, and two frame elements. The head unit includes a first support unit and a head part which is mounted in a height-adjustable manner on the first support unit. The foot unit includes a second support unit and a foot part which is mounted in a height-adjustable manner on the second support unit. The two frame elements connect the head unit and the foot unit and are spaced apart from each other. The foot unit ( | 2018-09-27 |
20180271732 | PATIENT PLACEMENT TABLE MOVING METHOD USED ON ROBOTIC OPERATING TABLE - A patient placement table moving method may be used with a robotic operating table including a patient placement table, a base buried in or fixed to a floor and an articulated robotic arm including joints and having first and second ends. The first end may be supported on the base to be rotatable about an axis extending in a vertical direction. The second end may support the table. The method may include: horizontally arranging the table by the robotic arm at an imaging position for imaging with a medical imaging apparatus; and translating the table from the imaging position to a surgical operation position by the robotic arm. The surgical operation position may be away from the imaging position by 200 mm or more in a second direction orthogonal to a first direction in a horizontal plane, and the first direction is parallel with a longitudinal direction of the table. | 2018-09-27 |
20180271733 | HEIGHT ADJUSTMENT DELIVERY TABLE - A height adjustment system for a delivery table or the like having a table top supported upon a height adjustable column with an assist cylinder. The system includes an actuator assembly to operate the assist cylinder from manual actuators, such as paddles, located approximately in four corners of table top. The system may include a pair of paddle assemblies mounted under the table top on opposite sides of said assist cylinder. The paddle assemblies may be coupled to the assist cylinder by a linear linkage that translates pivotal movement of a paddle into linear movement sufficient to actuate the assist cylinder. The linear linkage may include a straight drive rod coupled to one paddle assembly and an offset drive rod coupled to the other paddle assembly. The linear linkage may also include a pivot arm to reverse movement of the offset drive rod. | 2018-09-27 |
20180271734 | ROBOT SYSTEM FOR ORAL CAVITY AND TOOTH TREATMENT - A robot system for oral cavity and tooth treatment. The system includes a console, a seat device, a robot and a navigation device. The console includes a display device, an operating device and an emergency stop device. The seat device includes a body support portion, an orientation adjustment portion and a head fixing portion. The robot comprises a main controller, a robotic arm, a manipulator. The navigation device performs navigation inside a tooth in a root canal treatment operation according to pre-stored tooth information. The treatment instrument in the manipulator can be replaceable. The seat device can be adjusted such that a patient can face any direction between forward and downward, or lie prostrate. | 2018-09-27 |
20180271735 | MULTI-FUNCTIONAL FOAM FITNESS APPARATUS - A multi-layer foam fitness apparatus for use in strength and stretching exercises is provided. The apparatus has a user-engaging portion and a surface-engaging portion. The user-engaging portion is comprised of closed cell EVA foam of a first hardness, and the surface-engaging portion is comprised of a closed cell EVA foam of a second, lesser hardness, wherein the surface-engaging portion is comprised of non-slip memory foam. The user-engaging portion comprises one or more faces, which may be flat, angled, or curved, or some combination of the foregoing. | 2018-09-27 |
20180271736 | INVERSION METHODS AND APPARATUS - An inversion apparatus includes a support frame configured to movably support an inversion table. The support frame includes a forwardly extending foot platform that helps a user mount and dismount the apparatus when the apparatus is in an operative configuration. A cover is selectively mounted on top of the inversion table to provide padding and/or a low-friction sliding surface. A lumbar support is preferably connected to the inversion table to overlie a portion of the cover. | 2018-09-27 |
20180271737 | INVERSION METHODS AND APPARATUS - An inversion apparatus includes a support frame configured to movably support an inversion table. The support frame includes a forwardly extending foot platform that helps a user mount and dismount the apparatus when the apparatus is in an operative configuration. A CPU is preferably mounted on the inversion table to collect data and transmit to an output device, such as a mobile phone. | 2018-09-27 |
20180271738 | REHABILITATION SYSTEM AND METHOD - A rehabilitation system for rehabilitation of a subject including at least one end-effector for interacting with the subject, the end-effector having at least two degrees of freedom of motion, at least one actuator for actuating the at least one end-effector, at least one sensor for measuring at least the position and the speed of the at least one end-effector; at least one sensor for measuring the interaction force between the subject and the end-effector; a memory including at least two initial coefficients and a session including at least one exercise including at least one reference trajectory to be carried out by the subject through actuation of the end effector; and an actuator controlling unit. The memory delivers the initial coefficients and the session, the sensors deliver measurement signals to the controlling unit, and the controlling unit provides a force-controlled feedback based on the initial coefficients. | 2018-09-27 |
20180271739 | WALKING SUPPORT ROBOT AND WALKING SUPPORT METHOD - A walking support robot of the present disclosure is a walking support robot that moves in accordance with a handle force while supporting walking of a user. The walking support robot includes a body, a handle that is on the body and is held by the user, a sensor that senses a force applied to the handle, and a moving device that includes a rotating member and moves the walking support robot by controlling rotation of the rotating member in accordance with the force sensed by the sensor. The walking support robot estimates a leg position of the user on a basis of a change of the force sensed by the sensor, and sets a load to be applied to the user on a basis of the leg position. | 2018-09-27 |
20180271740 | SYSTEM AND METHOD TO ASSIST USERS HAVING REDUCED VISUAL CAPABILITY UTILIZING LIGHTING DEVICE PROVIDED INFORMATION - A lighting device obtains data related to objects and boundaries in an area in the vicinity of the lighting device, and a user wearable device provides a display (e.g. an augmented reality display based on the data related to the objects and the area boundaries) for a user/wearer. The lighting device includes a mapping sensor that collects data related to the objects and boundaries in the area. The user wearable device includes a camera or other optical sensor and wireless communication capability. The user wearable device is provided with mapping data that is presented on a display of the user wearable device. The communications and display capabilities allow the user wearable device to obtain room mapping information related to area in the vicinity of the lighting device in order to provide navigational assistance to a visually impaired person in the area. | 2018-09-27 |
20180271741 | MINIATURISED INSTRUMENT FOR SIMULATING SIMULTANEOUS VISION BY GENERATING MASKS - A miniaturised instrument for simulating simultaneous vision by generating masks is provided with a single image-forming optical channel. The instrument comprises: a mask-generating element (EGM) which generates at least two complementary masks, with a temporal frequency of alternation such that when one partially blocks the incident light, the other allows the incident light to partially pass, and vice-versa; an adjustable lens (LA) of variable optical power which generates, with said frequency of alternation, at least two different optical powers corresponding to at least two observation distances. The EGM and the LA are located in a single optical channel via which the incident light circulates, such that each mask of the EGM is temporally synchronised with a power of the LA. The combination of all the masks and optical powers produces, via high-speed temporal fusion, a pupil pattern wherein at least two optical powers corresponding to at least two observation distances are combined. | 2018-09-27 |
20180271742 | SYSTEMS AND METHODS FOR REGULATION OF ONE OR MORE EPIDERMAL PROTEINS - The disclosed embodiments provide skin stimulating devices and methods that address the aging effects of skin at a protein level. Particularly, cyclical mechanical strain is used to regulate specific proteins within the skin, so as to produce specific effects. As a non-limiting example, the disclosed embodiments can be used to increase the production of certain proteins (e.g., hyaluronan synthase 3 (HAS3); fibronectin; tropoelastin; procoll1; integrin, etc.) in the skin, which results in anti-aging effects by increasing epidermal cohesion. | 2018-09-27 |
20180271743 | DEVICE, SYSTEM, AND METHOD FOR MECHANOSENSORY NERVE ENDING STIMULATION - A device for stimulating mechanosensory nerve endings can include: a housing having an internal chamber and first and second openings; optionally, a membrane covering the first opening of housing, the membrane being sufficient flexibility to vibrate upon receiving vibratory stimulation from a vibratory mechanism; and a coupling mechanism at the second opening configured for being fluidly coupled to the vibratory mechanism, wherein the entire device is magnetically unresponsive materials. The housing can be cylindrical, or any polygon shape. The membrane can be integrated with the housing or coupled thereto, such as with adhesive. Optionally, the membrane can be removably coupled to the housing. The membrane can be omitted such that the skin of a subject coupled to the device oscillates in response to the fluid vibrations. | 2018-09-27 |
20180271745 | SYSTEMS AND METHODS FOR NASAL IRRIGATION - Systems and methods for nasal irrigation are provided in which a nasal irrigation device includes a source of saline solution, an effluent receptacle, a nasal interface, a vacuum source, a fluid passageway to communicate the source of saline solution with the effluent receptacle through the nasal interface and a nasal cavity of the user, and a switch and valve assembly for selectively controlling the vacuum source and flow of the saline solution through the fluid passageway. The saline solution source bottle is disposed relative to the device to provide gravitational inducement of saline solution to the nasal interface in engagement to the device user's nostrils. A combination of the gravitational inducement and the relative vacuum from an effluent receptacle generates a fluid flow for irrigating, cleansing and massaging the nasal cavity and ostia of a user. The entire device is assembled as a hand-held device for convenient lifting and disposal against the user's nostrils. | 2018-09-27 |
20180271746 | Packaged Multi-Dose Liquid Drug Formulation - Multi-dose packaged over-the-counter antitussive syrups comprise a bottle containing about 75 ml or less of a liquid formulation of dextromethorphan hydrobromide. The liquid formulation provides at least two doses of dextromethorphan hydrobromide. Multi-dose packaged over-the-counter liquid formulations comprise a bottle having a capacity of about 100 ml or less, at least two doses of the liquid formulation carried within the bottle, a cap, a dosage cup releasably carried on the cap and a shrink wrap substantially enveloping the bottle and the dosage cup. Antitussive syrups comprise water, dextromethorphan hydrobromide in amounts from about 6 to about 25 mg/ml, and sweetener in amounts from about 200 to about 800 mg/ml. | 2018-09-27 |
20180271747 | BIOMEDICAL CONTAINER TO COLLECT AND TEST BLOOD OR A BLOOD COMPONENT - Biomedical container to collect and test blood or a blood component, comprising a collection chamber for blood or a blood component; a test chamber for blood or a blood component; and a test kit in the test chamber to test the blood or the blood component contained therein. The collection chamber and the test chamber are intended to be connected so as to be unequivocally mutually associated and to be supplied with the same blood or blood component. | 2018-09-27 |
20180271748 | CONNECTION ASSEMBLY FOR DIRECTING A MEDICAL LIQUID - A connection assembly configured to deliver a medical liquid to a container is described. The connection assembly includes a connecting member connected to the container, an attachment member, and a sealing element. The attachment member defines a lumen, a first end to be connected to a delivery device, and a second end connected to the connecting member. The sealing element is disposed in the lumen of the attachment member and includes a sealing head, a flange, and a foot portion. The sealing head seals the lumen of the attachment member, and the flange and the foot portion engage the connecting member. | 2018-09-27 |
20180271749 | Sealed fluid transfer device and sealed fluid transfer method - The present invention discloses a sealed fluid transfer device and a sealed fluid transfer method. The device includes a first container puncture apparatus, a second container puncture apparatus and a fluid transfer apparatus, wherein the fluid transfer apparatus includes a first container puncture adapter, a second container puncture adapter and a pressure supply unit; the first container puncture adapter includes a sealing element fixed seat, a guided outer casing, a pipeline fixed seat, a first fluid pipeline and a second fluid pipeline; when the sealing element fixed seat is connected with the first container puncture apparatus, a first sealing element is firstly tightly connected with a second sealing element, the first fluid pipeline and the second fluid pipeline respectively pass through the two sealing elements and then communicate with the first container; after being firstly used, the first fluid pipeline and the second fluid pipeline are always in no contact with the exterior; the fluid in the second container and the fluid in the first container are transported in an internal manner so as not to be in contact with the outside air, thereby avoiding the direct contact of the hazardous fluids with the air or the human body. | 2018-09-27 |
20180271750 | DEVICE AND METHOD FOR EJECTING AT LEAST ONE CAPSULE FROM A CAPSULE HOLDER - A device for ejecting at least one capsule from a capsule holder. The capsule holder has at least two capsule receptacles for, in each case, one capsule. The device comprises: at least two ejectors, each of the ejectors being configured to eject a respective one of the capsules from the corresponding one of the receptacles; a drive unit configured to actuate the at least two ejectors independently of each other in an ejection direction and in an opposite return direction; the drive unit having a pneumatic actuating cylinder for each ejector; the pneumatic actuating cylinders being individually actuatable as a drive for respective ones of the at least two ejectors; a limiter element which is provided jointly for a plurality of the at least two ejectors and which has a cyclical lifting drive; and, each ejector being assigned a stop acting in the return direction for the limiter element. | 2018-09-27 |
20180271751 | Pill Crushing Assembly - A pill crushing assembly for crushing and cutting a pill includes a plunger unit that may be manipulated. A base is provided and the base may be positioned on a support surface. A pill is selectively positioned on the base. The plunger unit is selectively positioned on the base. Thus, the plunger unit selectively crushes the pill on the base. | 2018-09-27 |
20180271752 | DRUG DELIVERY CAPSULES WITH EXTERNAL INTELLIGENCE - A system for administering a medicament includes a plurality of capsules, a capsule dispenser, and a capsule activator. Each of the capsules includes a reservoir containing a medicament and an outlet in communication with the reservoir through which the medicament exits the capsule. The capsule dispenser releasably contains the ingestible capsules and is adapted to dispense the capsules to a user in accordance with a predetermined schedule. The capsule activator activates the dispensed capsules prior to administration to the user. | 2018-09-27 |
20180271753 | MEDICATION DISPENSING PHONE CASE SYSTEM - An apparatus and method for a medication dispensing phone case system. A system includes a smartphone, the smartphone including at least a processor, a memory and a display, the memory including at least an operating system and an adherence app, a connector system, the connector system removably linking the smartphone to a medication dispensing container, the connector system including at least sensing technology that enables the connector system to read an activity from the medication dispensing container, and a server in a network of interconnected computer devices, the server communicatively linked to the smartphone to enable interaction between the adherence app and an adherence process residing in the server. | 2018-09-27 |
20180271754 | METHOD FOR MAKING AN ACID ETCHED CANNABINOID MOLECULE BATH BOMB - Method for making a Cannabinoid molecule bath bomb by first etching the surface of at least one of Δ9 Tetrahydrocannabinol molecule and Cannabidiol molecule. The etched Cannabinoid molecule is then combined with Sodium Bicarbonate, Citric acid, Magnesium Chloride, and a viscous binder. Once the ingredients have been combined the resulting mixture is dried to form a Cannabinoid molecule bath bomb. | 2018-09-27 |
20180271755 | OIL-IN-WATER EMULSION SUNSCREEN COSMETIC - An oil-in-water emulsified sunblock cosmetic has excellent feeling when used and maintains a high ultraviolet-ray protective effect even upon contact with water or sweat. The oil-in-water emulsified sunblock cosmetic contains an (A) ultraviolet-ray protective agent and a (B) fatty acid forming a solid at room temperature, the cosmetic is characterized in that 51% or less of the fatty acid is neutralized, and the formulation ratio ((A)/(B) of the (A) ultraviolet-ray protective agent to the (B) fatty acid is in the range of at least 0.1 and less than 10.0. The cosmetic exhibits the unprecedented and surprising property of contact with water causing an improvement to the ultraviolet-ray protective ability. It is preferable for the cosmetic to contain an (C) oily component having IOB of 0.5 or higher. | 2018-09-27 |
20180271756 | INDIUM TIN OXIDE COATED PARTICLES AND COMPOSITIONS - Anhydrous topical compositions containing a solid or hollow particle ranging from 0.001 to 200 microns in diameter coated with Indium Tin Oxide (“ITO”) and methods for protecting skin against IR (infrared) radiation by topically applying the anhydrous compositions. | 2018-09-27 |
20180271757 | SUNSCREEN COSMETIC - A sunscreen cosmetic eliminates instability of a dibenzoylmethane derivative that is a UVA absorbing-agent, which exhibits excellent ultraviolet radiation protection performance across a wide wavelength region from UVA to UVB, and which exhibits excellent light resistance, is stable over time, and does not suffer from discoloration or crystal precipitation, and with which unnatural whiteness does not occur. A sunscreen cosmetic contains (a) a dibenzoylmethane derivative and (b) a powder that is surface-hydrophobized by means of treatment with a metal soap comprising a higher fatty acid and an alkaline earth metal or a combined treatment involving the use of a higher fatty acid and an alkaline earth metal hydroxide. The alkaline earth metal is preferably calcium or magnesium, and the higher fatty acid is preferably isostearic acid. | 2018-09-27 |
20180271758 | Cosmetic Antiperspirant Composition - A cosmetic antiperspirant composition, i.e., a perspiration-inhibiting or sweat-inhibiting composition, which comprises at least one active antiperspirant ingredient selected from the group consisting of hydroxycarboxylic acid, hydroxycarboxylic salt, and mixtures thereof. Preferably, the cosmetic antiperspirant composition is free of salts selected from the group consisting of aluminum salts, zirconium salts, and mixtures thereof | 2018-09-27 |
20180271759 | HAIR TREATMENT COMPOSITIONS - Use of a hair treatment composition comprising a lactone, a disaccharide, an inorganic salt and an organic acid or salt thereof, having a pH in the range of from 3 to 6.5, in the treatment of hair, to repair damage to hair protein, preferably to increase the denaturation temperature of the internal protein of hair. | 2018-09-27 |
20180271760 | Skin Care Compositions - A skin care composition comprising one or more alpha hydroxy acids, one or more salts of alpha hydroxyl acids, one or more tretinoin, retinols or retinol-like compounds, and niacinamide or hydroquinone. A method of treating skin with the skin care composition comprising the steps of a) cleaning the skin; and b) applying the skin care composition to the skin. | 2018-09-27 |
20180271761 | USE OF ADELMIDROL AND OTHER TOPICAL OR ORAL CANNABINOMIMETIC OR ALIAMIDE MAST CELL INHIBITORS TO TREAT DERMATOHELIOSIS, SEBORRHEIC KERATOSES, AND ANDROGENETIC ALOPECIA - A method of correcting the visible and microscopic signs of Dermatoheliosis (chronic ultraviolet light-damaged human skin) and its various clinical manifestations (wrinkling, sagging, fragility, melasma, Poikiloderma of Civatte, solar lentigines, and senile purpura) and also Androgenetic Alopecia and Seborrheic Keratoses consists of the administration of fatty acid derivatives capable of inhibiting mast cells and the mediators they release that cause local tissue damage. These fatty acid derivatives include palmitoylethanolamide (PEA) and related cannabinomimetic compounds and adelmidrol and related Autacoid Local Injury Antagonist amides (ALIAmides) which are administered orally or applied topically. Adelmidrol, the best absorbed topically, is applied in a concentration of between 1% and 10% by volume, with a preferred concentration of about 5% by volume. Normally produced in body tissues in response to the effects of painful and inflammatory mast cell mediators, these compounds must be added in these conditions to stop the progression of damage because the affected tissues lack inflammation due to the immunosuppressive effects of the chronic ultraviolet radiation that initiates and likely perpetuates them. | 2018-09-27 |
20180271762 | Oral Care Compositions and Methods of Use - This invention relates to oral care compositions comprising arginine or lysine, zinc citrate and zinc oxide, fluoride source, and a silica abrasive which exhibits an acid pH when measured as an aqueous slurry as well as to methods of using and of making these compositions. | 2018-09-27 |
20180271763 | BODY INK COMPOSITIONS AND APPLICATORS - A temporary tattooing ink is produced from concentrated genipin. In one embodiment, the concentrated | 2018-09-27 |
20180271764 | BODY INK COMPOSITIONS AND APPLICATORS - A temporary tattooing ink is produced from concentrated genipin. In one embodiment, the concentrated genipin forms part of a solution. In another embodiment, the genipin is provided in a gel form which also includes a solvent and a thickening agent. Finally, an applicator is described into which genipin may be embedded for applying to a user's skin. | 2018-09-27 |
20180271765 | ORAL CARE FORMULATION AND METHOD FOR THE REMOVAL OF TARTAR AND PLAQUE FROM TEETH - An oral care formulation and method for removing tartar and plaque from the teeth, gums, and oral cavity is disclosed. The oral care formulation can take the form of a toothpaste, gel, wash, rinse, soak, spray, chewing gum, dental floss, or other suitable delivery system, containing a therapeutically effective amount of dimethyl isosorbide (DMI) (or equivalent or analog thereof) and chlorine dioxide (ClO | 2018-09-27 |
20180271766 | ACRYLIC POLYMER COMPRISING ALKOXYSILANE GROUPS AND COSMETIC USES THEREOF - The invention relates to a cosmetic process for caring for or making up keratin materials, comprising either the topical application to the keratin materials of an (extemporaneous) anhydrous mixture of a cosmetic composition comprising a maleic anhydride acrylic polymer and of an amino alkoxysilane compound (I); or the sequential application to the keratin materials of an anhydrous cosmetic composition comprising a maleic anhydride acrylic polymer and of an amino alkoxysilane compound (I), wherein said maleic anhydride acrylic polymer is obtained by polymerization of: | 2018-09-27 |
20180271767 | USE OF SACCHARIDES FOR CRYOPROTECTION AND RELATED TECHNOLOGY - A method in accordance with a particular embodiment of the present invention includes increasing a concentration of a modified or unmodified saccharide within a subject's skin, applying an applicator to the subject's skin, and cooling the subject's skin via a heat-transfer surface of the applicator. The saccharide within the subject's skin can enhance a resistance of at least some cells within the subject's skin to damage associated with the cooling. A corresponding system includes the applicator, the saccharide, and an energy-delivery device. The energy-delivery device can be configured to apply ultrasound, optical, thermal, or another type of energy to the subject's skin to drive the saccharide into the subject's skin. The system can also include a penetration enhancer configured to enhance penetration of the saccharide into the subject's skin. The penetration enhancer can be applied with the saccharide or separately. | 2018-09-27 |
20180271768 | BIOCELLULOSE SLURRY, AND DRY BIOCELLULOSE MATERIAL, METHOD FOR MANUFACTURING DRY BIOCELLULOSE MATERIAL AND SKIN CARE FILM USING THE SAME - A bio-cellulose slurry is provided. The bio-cellulose slurry comprises the following components: bio-cellulose; a backbone fiber selected from the group consisting of rayon fibers, polyethylene terephthalate (PET) fibers, nylon fibers and combinations thereof; an adhesive fiber selected from polyethylene composite fibers; an adhesion promoter selected from the group consisting of polyamides, low density polyethylenes and combinations thereof; a humectant selected from polyols; and a dispersion medium. The bio-cellulose slurry is useful in manufacturing a dry bio-cellulose material with outstanding water absorption rate and wet strength. | 2018-09-27 |
20180271769 | MULTI-FUNCTIONAL ANTI-MICROBIAL POLYMERS AND COMPOSITIONS CONTAINING SAME - The present disclosure relates to multi-functional anti-microbial polymers comprising a first monomer having a polymerizable cyclic aromatic moiety which forms part of the backbone of the polymer and a second monomer having an ethylenically unsaturated monomer having a double or triple bond and a quaternary ammonium or quaternary phosphonium moiety. | 2018-09-27 |
20180271770 | Compositions And Methods Of Using The Same For Decontamination Of Skin - The present disclosure provides compositions comprising decontaminating compounds, and pharmaceutically acceptable salts thereof and methods of treating or preventing a contamination in a mammal, in particular, the composition can include a mixture of polyvinyl acetate and povidone, a cobloek polymer of ethylene oxide and propylene oxide, a polyvinyl alcohol, or combinations thereof, and an aqueous suspending agent. | 2018-09-27 |
20180271771 | POLYURETHANEUREA SOLUTIONS FOR COMPOSITIONS WITH ACTIVE INGREDIENTS OR FRAGRANCES - The present invention relates to a composition for application to the human and animal body or to plants, comprising at least one active ingredient and/or fragrance, comprising a polyurethane urea which is dissolved in a solvent or solvent mixture, the solvent consisting of one or more monohydroxy-functional alcohols, or a solvent mixture consisting of organic solvents, which contains ≥50% by weight, based on the total mass of the solvent mixture, of at least one monohydroxy-functional alcohol, is used. The invention additionally embraces the composition for treating the human or animal body, the use of the composition to coat substrates, the substrates not being the human or animal body, and the use of the composition for application to the human or animal body, the active ingredient not having a therapeutic effect. | 2018-09-27 |
20180271772 | Compositions and Methods for Stimulation MAGP-1 to Improve the Appearance of Skin - The present disclosure relates to methods for treating, preventing and improving the condition and aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, by application of one or a combination of natural compounds or extracts that stimulate MAGP-1 expression and which improves the appearance of aged and/or photodamaged skin. The compositions of the invention are topically applied to the skin, or are delivered by directed means to a site in need thereof in an amount effective to improve the condition and aesthetic appearance of skin. | 2018-09-27 |
20180271773 | COMPOSITION FOR IMPROVING SKIN AND PREVENTING HAIR-LOSS COMPRISING EXTRACELLULAR VESICLES FROM VEGETABLE EXTRACTION - The present invention relates to a composition containing extracellular vesicles derived from plant juice, wherein the extracellular vesicles have excellent skin condition-improving effects such as skin whitening, moisturizing and wrinkle reducing effects and exhibits an excellent effect of preventing hair loss by promotion of hair growth and regrowth, and the like. | 2018-09-27 |
20180271774 | INFUSION OBTAINED FROM A MIXTURE OF SPECIES OF THE SIDERITIS PLANT FOR TOPICAL CUTANEOUS OR OTHER USE AND PRODUCTION METHOD THEREFOR - Infusion from a mixture of species of the | 2018-09-27 |
20180271775 | Oral Care Composition Comprising Cuttlefish Bone Powder and Uses Thereof - The present document describes an oral care composition comprising a cuttlefish bone powder, comprising particles having more than 95% (w/w) calcium carbonate content, and a particle size of from about 60 microns to about 75 microns, and a suitable carrier, and uses of said composition for oral hygiene. | 2018-09-27 |
20180271776 | Hydrogen-Generating Effervescent Tablet and Methods Thereof - Convenient, inexpensive and portable effervescent tablets that the consumer can add to water to generate hydrogen-rich water just prior to drinking. The effervescent tablets include a base metal and an edible acid that, within about 5-10 minutes of mixing, generate a palatable aqueous solution having about 0.8 mM to about 3 mM hydrogen and a pH of 8-10. | 2018-09-27 |
20180271777 | Compositions and Methods for the Delivery of Agents - The present invention relates to methods and compositions for the delivery of cosmetics and medicants. In some embodiments, the invention relates to compositions comprising both hydrophobic and hydrophilic polymers. In preferred embodiments, the invention relates to the delivery of peptides, small molecules and other bioactive compounds using the compositions and methods disclosed herein. | 2018-09-27 |
20180271778 | Immunogenic Composition Against Campylobacter Jejuni - The inventive subject matter relates to an immunogenic composition against | 2018-09-27 |
20180271779 | Injectable and Biodegradable Polymer Formulations For Controlled Release of Biologic Agents - The present disclosure is directed to injectable formulations that include biodegradable polymers based on trimethylene carbonate (TMC) with mole fractions of polylactic acid (PLA) and/or polyglycolic acid (PGA) that are used to deliver a bioactive agent to a targeted site. Excipients such as polyethylene glycol (PEG) may be added to the formulations to reduce the injection force and/or to modulate the release of the bioactive agent. Suitable biodegradable polymers for use in the injectable formulations include D,L-PLA:TMC, D-PLA:TMC, L-PLA:TMC, TMC:PLA:PGA and variations thereof. Additionally, copolymers of TMC and PLA and terpolymers of TMC:PLA:PGA may be formed into nanoparticles and delivered to the target site with an injectable crosslinkable polyethylene glycol system. In at least one embodiment, the injectable formulations are used to treat ocular diseases. | 2018-09-27 |
20180271780 | COMPOSITIONS AND METHODS FOR TREATING HYPEREMIA - Compositions and methods for treating hyperemia and symptoms in pinguecula and pseudopteryigium are disclosed. The methods include administration of a multikinase inhibitor, an antimetabolite or a combination thereof to patients in need thereof. | 2018-09-27 |
20180271781 | COMPOSITIONS AND METHODS FOR TREATING PTERYGIUM - Compositions and methods for treating hyperemia and symptoms in pterygium patients are disclosed. The methods include administration of a multikinase inhibitor, an antimetabolite or a combination thereof to patients in need thereof. | 2018-09-27 |
20180271782 | PARTICLES, COMPOSITIONS AND METHODS FOR OPHTHALMIC AND/OR OTHER APPLICATIONS - Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye. | 2018-09-27 |
20180271783 | REPEATED ADMINISTRATION OF LENTIVIRAL VECTORS TO RESPIRATORY CELLS - The invention provides methods for administering lentiviral vectors to the respiratory system of a patient to treat a disease. | 2018-09-27 |
20180271784 | Methods for Producing Carboxylate Ligand Modified Ferric Iron Hydroxide Colloids and Related Compositions and Uses - Processes for recovering colloids of carboxylate ligand modified ferric iron hydroxide materials such as IHAT (Iron Hydroxide Adipate Tartrate) are described based on the use of water miscible non-aqueous solvents, such as ethanol, methanol and acetone. The processes produce materials with advantageous properties such as improved bioavailability, reduced aggregation and/or agglomeration and/or increased iron content. | 2018-09-27 |
20180271785 | OPHTHALMIC EMULSION - The present invention is directed to an ophthalmic emulsion. The emulsion has a unique combination of ingredients that promotes the stability of small oil droplets within the emulsion. The emulsion also includes a mucoadhesive polymer that aid in delivering a lipid to the ocular surface. | 2018-09-27 |
20180271786 | ENEMA FOR RECTAL APPLICATION - Provided is an enema for rectal application containing budesonide as an active ingredient in order to treat inflammatory bowel disease, or to prevent a relapse. The enema for rectal application containing budesonide as the active ingredient, in which 1.5 to 2.5 mg of budesonide per dose is administered twice a day for 6 weeks in order to treat inflammatory bowel disease, or to prevent a relapse; the enema for rectal application described above, in which a dose of budesonide is 2.0 mg per dose; the enema for rectal application according to any one of the above, which is taken in order to treat ulcerative colitis or Crohn's disease, or to prevent a relapse; the enema for rectal application according to any one of the above, which has a foamy shape or a liquid shape. | 2018-09-27 |
20180271787 | COMBINATION METHODS AND COMPOSITIONS - Compositions which comprise a liposomal camptothecin and optionally liposomal fluoropyrimidine and a targeted antitumor agent are useful in achieving enhanced therapeutic effects when combinations of these agents are administered. | 2018-09-27 |
20180271788 | VESICLE CONTAINING METALLIC NANOPARTICLE AND METHOD FOR PRODUCTION THEREOF - Disclosed is a method of producing a vesicle containing a metallic nanoparticle that is covalently bound to at least one hydrophilic polymer and at least one hydrophobic polymer, wherein the method involves dispersing the polymer-bound metallic nanoparticle in an organic solvent, adding an aqueous solution containing a dispersing aid to form a mixed solution, sonicating the mixed solution to form an emulsion; and removing the organic solvent from the emulsion until the vesicle forms. Using this method, the formed vesicle has a diameter of 20-150 nm, which is useful for a method of conducting photothermal therapy (PTT) for killing cells, such as cancer cells. | 2018-09-27 |
20180271789 | SUSTAINED-RELEASE COMPOSITION, METHOD FOR FABRICATING, AND USE THEREOF - The present disclosure provides a sustained-release composition including a sodium hydrosulfide and a carrier. The carrier is provided for carrying the sodium hydrosulfide with an effective amount and includes a first component and a second component. The first component includes a paraffin wax, and the second component includes a fatty alcohol, a fatty acid or a phospholipid. The present disclosure also provides a method for fabricating the sustained-release composition. The method includes providing a first solution, providing the carrier, providing a second solution, performing an oil-in-water emulsification, and cooling the emulsion. In addition, the present disclosure provides a method for treating the chronic wounds. The method includes administering an effective amount of the aforementioned sustained-release composition to a subject suffered from the chronic wounds. | 2018-09-27 |
20180271790 | STABLE BENZIMIDAZOLE FORMULATION - A benzimidazole formulation which lacks an intermediate layer and yet which is stable both during storage and during the passage through the stomach, and which has low levels of residual volatile excipients, including but not limited to residual alkalinizing agents and/or residual solvents. | 2018-09-27 |
20180271791 | SYSTEMS AND METHODS FOR THE FABRICATION OF TABLETS, INCLUDING PHARMACEUTICAL TABLETS - Systems and methods for fabricating ingestible pharmaceutical tablets are provided. Certain of the systems and methods described herein are capable of manufacturing tablets of different dosages without the need to fluidically connect or disconnect unit operations when switching from a tablet having a first dosage to a tablet having a second, different dosage. Certain of the systems and methods described herein are capable of manufacturing compositionally tablets, e.g., tablets with different active pharmaceutical ingredients (APIs). | 2018-09-27 |
20180271792 | ORAL DELIVERY OF PHYSIOLOGICALLY ACTIVE SUBSTANCES - Embodiments may include a composition for oral drug delivery. The composition may include a physiologically active substance, a carrier compound, a mucoadhesive compound, and a permeation enhancer. The physiologically active substance may be transported across the stomach. The physiologically active substance may be stable and not degrade in the harsh gastric acid environment. To help protect the physiologically active substance, the physiologically active substance is mixed with the carrier. The carrier may be a liquid insoluble in the gastric acid of the stomach. The physiologically active substance may be soluble in the carrier. The mucoadhesive compound may be used to promote adsorption of the physiologically active substance to the lining of the stomach. The permeation enhancer may facilitate the transport of the physiologically active substance across the wall of the stomach. | 2018-09-27 |
20180271793 | METHOD TO GENERATE MICROCAPSULES WITH HEXAHYDROTRIAZINE (HT)-CONTAINING SHELLS - Materials and methods for preparing a payload-containing microcapsule with walls that have hexahydrotriazine (HT) and/or hemiaminal (HA) structures are disclosed. To an HT small molecule or a HA small molecule, or a combination thereof, in a solvent is added a cross-linking agent, NH | 2018-09-27 |
20180271794 | ENCAPSULATED CELLS PRODUCING CYTOCHROME P450 AND METHODS OF USE THEREOF - Disclosed herein are methods and compositions to treat solid tumors. In one embodiment, the method of treating a solid tumor in a patient includes administering at the tumor site a therapeutically effective amount of cytochrome P450 producing cells encapsulated in a capsule and administering a prodrug which is activated by cytochrome P450, wherein the prodrug is administered at least three or more cycles, and wherein each cycle comprises three consecutive daily administration. | 2018-09-27 |
20180271795 | POLYNUCLEOTIDES ENCODING METHYLMALONYL-CoA MUTASE - The disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human methylmalonyl-CoA mutase precursor, human methylmalonyl-CoA mutase (MCM) mature form, or functional fragments thereof. In some embodiments, the disclosure includes methods of treating methylmalonic acidemia in a subject in need thereof comprising administering an mRNA encoding an MCM polypeptide. | 2018-09-27 |
20180271796 | COMPOSITIONS AND METHODS TO IMPROVE NANOPARTICLE DISTRIBUTION WITHIN THE BRAIN INTERSTITIUM - Improved distribution can be achieved by delivering nanoparticles possessing non-adhesive surfaces via CED in a hyperosmolar infusate solution. This delivery strategy minimizes the hindrances imposed by the brain extracellular matrix and reduces the concentration of therapeutic that is confined within perivascular spaces. | 2018-09-27 |
20180271797 | Method and apparatus for the manufacture of fibrous dosage forms - Recently, we have introduced fibrous dosage forms that enable predictable microstructures with a greater range of pharmaceutically relevant properties. Presented herein, accordingly, are a method and an apparatus for the manufacture of such fibrous dosage forms. The method includes extruding a plasticized matrix through an exit port of an extrusion channel to form at least one plasticized fiber, and structuring said at least one plasticized fiber to a three dimensional structural network of fibers. The apparatus includes an internally hollow housing defining an extrusion channel, a conveying element for extruding a plasticized matrix in the extrusion channel through an exit port to form at least one plasticized fiber, and a unit for structuring said at least one plasticized fiber to a three dimensional structural network of fibers. | 2018-09-27 |
20180271798 | METHODS AND COMPOSITIONS FOR MODIFYING MUCOUS MEMBRANES - The present invention relates to methods and compositions for modifying mucous membranes. In particular, the present invention relates to treating diseases associated with mucous membranes by changing the intrinsic chemical composition and/or physical features of a target mucous membrane. | 2018-09-27 |
20180271799 | MICROCELL DELIVERY SYSTEMS INCLUDING CHARGED OR MAGNETIC PARTICLES FOR REGULATING RATE OF ADMINISTRATION OF ACTIVES - An active molecule delivery system whereby active molecules can be released on demand and/or a variety of different active molecules can be delivered from the same system and/or different concentrations of active molecules can be delivered from the same system. The active delivery system includes a plurality of microcells, wherein the microcells are filled with a medium including an active ingredient and charged or magnetic particles. The microcells include an opening, and the opening is spanned by a porous diffusion layer. Because the porous diffusion layer can be blocked with the charged or magnetic particles, the rate at which the active ingredient is dispensed can be controlled with an electric or magnetic field, respectively. | 2018-09-27 |
20180271800 | MICROCELL SYSTEMS FOR DELIVERING ACTIVE MOLECULES - An active molecule delivery system whereby active molecules can be released on demand and/or a variety of different active molecules can be delivered from the same system and/or different concentrations of active molecules can be delivered from the same system. The active delivery system includes a plurality of microcells, wherein the microcells are filled with a medium including active molecules. The microcells include an opening, and the opening is spanned by a porous diffusion layer. The microcell arrays may be loaded with different active ingredients, thereby providing a mechanism to deliver different, or complimentary, active ingredients on demand. | 2018-09-27 |
20180271801 | Zeaxanthin Formulations With Additional Ocular-Active Nutrients, For Protecting Eye Health And Treating Eye Disorders - Oral formulations for promoting eye health, and in particular for preventing or treating macular degeneration, are disclosed, containing zeaxanthin, a carotenoid pigment, and at least two or more additional ocular-active nutrients selected from lipoic acid, omega-3 fatty acids, plant-derived compounds such as flavonoids, anthocyanins, or polyphenolics, taurine, carnitine, Coenzyme-QM, carnosine, and nutrients that stimulate the production of glutathione. Processes are disclosed for identifying ocular-active nutrients that will interact in a synergistic and potentiating manner with zeaxanthin, to provide better and more effective protection, for eye health, than can be provided by zeaxanthin alone. Additional optional agents include zinc, vitamin E, and vitamin C. | 2018-09-27 |
20180271802 | METHODS OF DIAGNOSIS AND TREATMENT INVOLVING NITRITE - Methods and therapeutics for treating nitric oxide (NO) mediated condition comprising administering a therapeutically effective amount of a pharmaceutical composition containing a therapeutic, wherein the therapeutic one of increases xanthine oxidase (XO) associated nitrite conversion to nitric oxide and increases nitrite conversion to nitric oxide via DADS. Method and devices for measuring an amount of nitrite in a sample comprising obtaining a sample, adding diallyl disulfide (DADS) to the sample, measuring a post DADS amount of nitric oxide (NO) in the sample, and using the post DADS amount of NO in the sample to determine the amount of nitrite in the sample. Methods and therapeutics for diagnosing and treating critical limb ischemia (CLI) versus non-critical limb ischemic peripheral artery disease (PAD) in a patient comprising determining a patient indicator value, where the patient indicator is value one of a total hydrogen sulfide metabolite plasma level, a total nitric oxide, nitrite, and nitrite (NOx) plasma level, a ratio of free hydrogen sulfide plasma level to total NOx plasma level, and a ratio of total hydrogen sulfide metabolite plasma level and total NOx plasma level, diagnosing the patient with as having CLI based on the patient indicator value, and administering to the patient a therapeutic for CLI. | 2018-09-27 |
20180271803 | COMPOSITIONS AND METHODS FOR TREATMENT OR PREVENTION OF ORAL MUCOSITIS - Radiation therapy or chemotherapy may cause oral mucositis. Compositions are disclosed here which prevent and/or treat oral mucositis caused by radiation therapy or chemotherapy. The compositions are also effective in treating a number of skin disorders. | 2018-09-27 |
20180271804 | 6-SHOGAOL DERIVATIVES AND ACTIVITIES THEREOF - Derivatives of 6-shogaol are described herein. Also described herein are methods of preparing the derivatives, as well as methods of using the derivatives to activate Nrf2 and to treat diseases associated with inflammation and/or oxidative stress. | 2018-09-27 |
20180271805 | COMPOSITION FOR THE TREATMENT OF HUMAN AND MAMMALIAN ATHEROSCLEROSIS AND PATHOLOGICAL CALCIFICATION IN TISSUE - A compound for treatment of a disorder characterized by at least one of pathological calcification and/or plaque formation including a nutraceutical supplement and a sequestrant, wherein the compound does not include an antibiotic. | 2018-09-27 |
20180271806 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS - The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for use, and their pharmaceutical compositions. | 2018-09-27 |
20180271807 | Meglumine in Combination with Another Therapeutic - The invention relates to a method of treating or preventing a condition in a subject, comprising administering to the subject an acceptable composition comprising meglumine or a salt thereof. The invention further relates to a method of improving a physiological function in a subject, comprising administering to the subject an acceptable composition comprising meglumine or a salt thereof. | 2018-09-27 |