39th week of 2011 patent applcation highlights part 50 |
Patent application number | Title | Published |
20110236878 | Rapid Characterization of Proteins in Complex Biological Fluids - Disclosed herein are compositions and methods for the rapid screening of candidate protein therapeutics. In particular, the instant invention provides compositions and methods for assaying the behavior of candidate protein therapeutics in complex biological fluids and for identifying those candidate protein therapeutics exhibiting desirable pharmacokinetic properties in such fluids. | 2011-09-29 |
20110236879 | METHODS AND COMPOSITIONS FOR ANALYTE DETECTION - The present invention is directed to methods and apparatus for detection of one or more analytes. Analytes include agents or components of infectious agents such as pathogenic virus, as well as enzymes, proteins and biomarkers. | 2011-09-29 |
20110236880 | Potentiated Biocidal Compositions and Methods of Use - The present technology relates to biocidal compositions and methods that contain and utilize at least one biocidal agent and at least one potentiator system wherein the resultant combination has an enhanced biocidal efficacy. The present technology also discloses a rapid screening assay for determining biocidal compositions with enhanced efficacy, e.g., a microbial contact kill time of 5 minutes or less. Further, the present technology provides a method of determining biocidally effective concentrations of biocidal compositions comprising at least one biocidal agent and at least one potentiator system. | 2011-09-29 |
20110236881 | MODULATION OF INFLUENZA VIRUS - The present invention provides, among other things, methods for the identification of compounds that are capable of modulating the activity of the influenza A virus. For example, the present methods provide platforms for identifying small molecule inhibitors that target the proton transport pathway defined at least in part by two or more of the highly conserved channel residues 27, 30, 31, 34, 37, 41, 44, and 45 of the influenza A M2 protein. In one aspect, the present invention is directed to methods comprising comparing spatial models of a plurality of test compounds with the spatial model of the pathway defined by at least two residues from among residues 27, 30, 31, 34, 37 or 41, 44, and 45 on one or more subunits of the M2 transmembrane protein of the influenza A virus to determine the spatial complementarity of each of the test compounds with the pathway; assessing the ability of the test compounds to bind to the pathway; and, based on the assessed ability of the test compounds to bind the pathway, determining the compound that modulates the activity of influenza A. | 2011-09-29 |
20110236882 | QUANTITATIVE MEASUREMENT OF NANO/MICRO PARTICLE ENDOCYTOSIS WITH CELL MASS SPECTROMETRY - Methods for detecting the presence of nanoparticles or microparticles by cell mass spectrometry (CMS) are provided. CMS methods are provided for determining the number of nanoparticles or microparticles in each cell. Nanoparticles whose intracellular concentration can be determines by the CMS methods of the invention include polymeric nanoparticles (NPs), liposomes, viral-based NPs, carbon nanotubes, diamond NPs, polymeric micelles, nanocarriers, liposomes, and viral nanoparticles. Determination of the efficiency of drug delivery and intracellular titer of pathogens according to the invention is disclosed. Methods for determining intracellular uptake of virus particles are provided. | 2011-09-29 |
20110236883 | DETECTION OF HERPES SIMPLEX VIRUS TYPES 1 AND 2 BY NUCLEIC ACID AMPLIFICATION - The present invention relates to a method of detecting the presence or absence of herpes simplex virus (HSV) in a sample based on amplifying a portion of the Glycoprotein G(US4) gene of HSV and detecting the presence of the amplified nucleic acid using primers and detector primers as described herewith. The method of the invention further identifies the type of HSV, either HSV-1 or HSV-2, in a sample. Also encompassed by the invention is a kit comprising the primers and detector primers which may be used with the amplification method described herewith. | 2011-09-29 |
20110236884 | MICROBUBBLES FOR AFFINITY SEPARATION - The present invention relates to methods, compositions and kits for affinity isolation, affinity purification and affinity assay based on microbubbles coated with an affinity molecule. Particularly, the invention provides protein microbubbles coated with an affinity molecule. In addition, the invention provides glass microbubbles coated with an affinity molecule. Methods of using the microbubbles of the invention for isolating analytes and cells are specifically provided. | 2011-09-29 |
20110236885 | Genetic Variants Predicting Warfarin Sensitivity - We discovered that a polymorphism in the promoter of the VKORC1 gene is associated with warfarin sensitivity. This polymorphism can explain both the inter-individual and inter-ethnic differences in warfarin dose requirements. Furthermore, the polymorphism is also associated with promoter activity. Thus, the promoter sequence or activity of the VKORC1 gene of a subject can be used to predict how much warfarin should be prescribed for the subject. Relevant methods and compositions are provided. | 2011-09-29 |
20110236886 | PATHOGENICITY DETERMINANTS WHICH CAN BE USED AS TARGETS FOR DEVELOPING MEANS FOR PREVENTING AND CONTROLLING BACTERIAL INFECTIONS AND/OR SYSTEMIC DISSEMINATION - The invention relates to a method for identifying and selecting a gene required for the proliferation in vivo of a pathogenic microorganism, comprising:—using a strain of the pathogenic microorganism,—generating mutants for inactivation in the genes encoding these factors,—determining the virulence of these mutants on an experimental model of infection, and their effect on enteric colonization in an axenic mouse model, and—selecting the bacterial genes essential for resistance to serum in vitro, and essential, in the host, for dissemination in the serum. Application to the screening of compounds which inhibit the products of the genes identified, and to the inhibition in vitro of the proliferation of a pathogenic microorganism in serum. | 2011-09-29 |
20110236887 | MODIFIED ACTINOMYCIN-BASED NUCLEIC ACID STAINS AND METHODS OF THEIR USE - Actinomycin-based near IR emitting compounds and methods of their use as nucleic acid stains are provided. | 2011-09-29 |
20110236888 | METHOD FOR ACCESSING THE CONTENTS OF A CLOSED VESSEL CONTAINING A SPECIMEN RETRIEVAL DEVICE - Method for obtaining a fluid from a collection device assembled to isolate a specimen retrieval device from the pathway of a fluid transfer device used to penetrate a cap of the collection device and to draw and remove the fluid from the collection device for analysis. | 2011-09-29 |
20110236889 | METHODS OF SCREENING FOR COMPOUNDS FOR USE AS MODULATORS OF LEFT-RIGHT ASYMMETRY IN SCOLIOTIC SUBJECTS AND FOR MONITORING EFFICACY OF AN ORTHOPAEDIC DEVICE - A method of screening for a compound for treating or preventing adolescent idiopathic scoliosis (AIS), said method comprising: (a) contacting a test compound with a paraspinal skin fibroblast or a paraspinal muscle cell sample from the right and/or left side of the spine of a subject; and (b) determining at least one of Nodal, Notch1, Pitx2, Lefty1 and Lefty2's expression and/or activity in the cell sample; wherein the test compound is selected as potentially useful in treating or preventing AIS if at least one of Nodal, Notch1, Pitx2, Lefty1 and Lefty2's expression and/or activity in the cell sample is different in the presence of the test compound as compared to in the absence thereof. | 2011-09-29 |
20110236890 | METHOD OF SCREENING FOR CANCER BY DETECTING MUTATIONS IN THE DELTA-CATENIN GENE PROMOTER AND 5'-UNTRANSLATED REGION - A method for screening for risk of cancer in a subject is carried out by detecting the presence or absence of at least one mutation in the delta-catenin gene promoter or 5′ untranslated region in a biological sample from said subject, the presence of such mutation or an increased frequency of mutation indicating said subject is afflicted with or at least at risk of developing cancer. | 2011-09-29 |
20110236891 | NUCLEIC ACID TEMPLATE PREPARATION FOR REAL-TIME PCR - The invention teaches a novel reagent formulation for the efficient preparation of a nucleic acid template from cells for high throughput real-time PCR analysis. The reagent permits rapid cell lysis and template preparation without the need for template purification and isolation. The reagent therefore dramatically improves throughput of real-time PCR analysis while at the same time permitting the rapid and sensitive real-time Catacleave PCR detection of a single molecule of nucleic acid template in as little as about 35 cycles of PCR amplification. | 2011-09-29 |
20110236892 | METHOD FOR LOWERING THE DEPENDENCY TOWARDS SEQUENCE VARIATION OF A NUCLEIC ACID TARGET IN A DIAGNOSTIC HYBRIDIZATION ASSAY - A primer or/and probe for a target sequence containing at least one variation, defined as either one non-conserved nucleotide, called genotype variation, or one nucleotide variation within one and the same genotype, wherein the primer or/and probe has a nucleic acid sequence that is complementary to said target sequence except for the at least complementary base of the variation(s), which is not present in the primer or/and probe. | 2011-09-29 |
20110236893 | LGR5 MODULATORS IN THE TREATMENT OF ALOPECIA - An in vitro method of screening for candidate compounds for the preventive or curative treatment of alopecia, which comprises determining the ability of a compound to modulate the expression or the activity of the LGR5 receptor is described. The use of modulators of the expression or of the activity of this receptor for treating alopecia is also described. In addition, methods for the diagnosis or prognosis, in vitro, of this disease are described. | 2011-09-29 |
20110236894 | SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS - The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation. | 2011-09-29 |
20110236895 | METHOD FOR PREPARING SAMPLE, SOLUTION FOR PREPARING SAMPLE AND STOOL COLLECTION KIT METHOD FOR ANALYZING A NUCLEIC ACID - The present invention relates to the providing of a method for preparing a sample from a nucleic acid-containing sample such as biological samples, where inhibitory substance's action against a enzyme reaction using a nucleic acid as substrate are decreased, a solution for preparing a sample used for the method, a stool collection kit used in that method, and a method for recovering and analyzing a nucleic acid in a nucleic acid-containing sample using a sample prepared using the preparation method of the present invention. A method for preparing a sample according to the present invention is a method for preparing a sample being used for analyzing a nucleic acid, and is characterized in that a nucleic acid-containing sample is mixed with a solution having one or more members selected from the group consisting of a polycation and a chelating agent as an active ingredient. | 2011-09-29 |
20110236896 | RGS2 GENOTYPES ASSOCIATED WITH EXTRAPYRAMIDAL SYMPTOMS INDUCED BY ANTIPSYCHOTIC MEDICATION - The present invention identifies genotypes associated with resistance to extrapyramidal symptoms induced by antipsychotic drugs. The present invention further identifies genotypes associated with predisposition to the onset or aggravation of extrapyramidal symptoms induced by antipsychotic drugs and use thereof for assessment of patient populations. Specifically, the present invention relates to particular polymorphisms in the RGS2 gene that are associated with resistance or susceptibility to drug-induced extrapyramidal symptoms. | 2011-09-29 |
20110236897 | NOVEL MARKERS FOR DIAGNOSING BRAIN DISEASE CAUSED BY BRAIN INJURY AND USE THEREOF - The present invention relates to novel markers for diagnosing brain disease caused by brain injury and the use thereof. More particularly, the present invention relates to novel diagnostic markers for brain disease caused by brain injury, which are identified by administering an MDMA drug, a diagnostic composition for brain disease caused by brain injury, a kit, a microarray, and a method for diagnosing brain disease caused by brain injury using the same, and relates to a method for screening a material for preventing or treating brain disease and a composition for preventing or treating brain disease caused by brain injury including the material. It was found that the expression amount of the marker genes of the present invention in tissues or cells of a patient with brain injury was over-expressed or under-expressed compared with that in normal tissues or cells. Thus, when used as diagnostic markers for brain disease caused by brain injury, the marker genes of the present invention can quickly and accurately diagnose and predict brain disease caused by brain injury at an early stage, and, particularly, can diagnose and predict brain disease caused by brain injury, which could be induced by an MDMA drug in the next generation. | 2011-09-29 |
20110236898 | METHODS FOR ENHANCING NUCLEIC ACID HYBRIDIZATION - A composition comprising an oligonucleotide having the structure 5′-Y | 2011-09-29 |
20110236899 | Method and Apparatus for Predicting Pharmaceutical Efficacy of Anti-TNFa Antibody Drug Against Rheumatoid Arthritis - A method for predicting a pharmaceutical efficacy of an anti-TNFα antibody drug against rheumatoid arthritis, the method including measuring an amount of ADAMTS5 contained in a sample derived from a subject, and determining whether or not the anti-TNFα antibody drug is efficient against rheumatoid arthritis by employing the amount of ADAMTS5 as an index. | 2011-09-29 |
20110236900 | NOVEL MUTS PROTEIN AND METHOD FOR DETERMING MUTATION USING THE SAME - A method for determining the presence or absence of a mutation on the basis of the presence or absence of amplification with high reliability is provided. A target sequence including a target site contained in a sample nucleic acid is amplified using a primer that can hybridize to a region including the target site contained in the sample nucleic acid in the presence of a novel MutS having an amino acid sequence of SEQ ID NO: 2, and then the presence or absence of a mutation at the target site is determined on the basis of the presence or absence of amplification. The novel MutS binds more specifically to a mismatched base pair than to a fully-matched base pair, whereby an extension reaction caused by a mismatch-binding primer is suppressed. Thus, according to the present invention, the presence or absence of a mutation can be determined with high reliability. | 2011-09-29 |
20110236901 | THERMAL CYCLING SYSTEM COMPRISING TRANSPORT HEATER - To provide a thermal cycling system allowing an efficient thermal cycling and an optical detection during the diagnostic process a thermal cycling system is proposed, comprising: at least one heating device ( | 2011-09-29 |
20110236902 | TESTING A PATIENT POPULATION HAVING A CARDIOVASCULAR CONDITION FOR DRUG EFFICACY - Lumenectomy material is tested to determine the efficacy of a test drug in a patient population having a cardiovascular condition. The material is removed from at least a first and a second patient and tested for one or more markers of a cardiovascular condition. The first patient is administered the test drug, and the second patient is administered a placebo. At a later date, more lumenectomy material is removed and tested for the same marker or markers. The presence, absence or amount of the markers is compared in the first patient receiving the drug and the second patient receiving the placebo to determine whether the drug is effective in the patient population. The drugs tested include drugs believed to be effective in treating a cardiovascular condition. The markers used can include any marker that can indicate the effectiveness of the drug being tested. | 2011-09-29 |
20110236903 | MATERIALS AND METHODS FOR DETERMINING DIAGNOSIS AND PROGNOSIS OF PROSTATE CANCER - Materials and Methods related to diagnosing and/or determining prognosis of prostate cancer. | 2011-09-29 |
20110236904 | DETECTION OF TUMOR STEM CELLS AND TUMOR CELLS IN EPITHELIAL-MESENCHYMAL TRANSITION IN BODY FLUIDS OF CANCER PATIENTS - The present invention relates to the detection of tumor stem cells and tumor cells in epithelial-mesenchymal transition and uses of such methods. | 2011-09-29 |
20110236905 | METHOD FOR SCREENING CATTLE, CATTLE SCREENED, AND CATTLE SCREENING KIT - There are provided a method for screening individual cattle having useful economic traits in which proteins related to the economic traits of beef cattle are identified by proteomics and are used as biomarkers, and a cattle screening kit for use in the method. | 2011-09-29 |
20110236906 | SECRETORY PROTEIN BIOMARKERS FOR HIGH EFFICIENCY PROTEIN EXPRESSION - The instant invention relates to the field of protein production, and in particular is relates to compositions and processes for improving the production levels of recombinant proteins expressed in host cells. | 2011-09-29 |
20110236907 | RADIOLABLED CYCLOPAMINE ASSAY FOR THE SMOOTHENED RECEPTOR - The present invention discloses novel methods for screening compositions for both agonist and antagonist activity on the smoothened receptor. The assay tests ligands on the activity of the receptor using a cyclopamine binding and ultra high receptor expression. | 2011-09-29 |
20110236908 | TOTAL PLASMA FVII/FVIIA LEVELS AS INDICATORS OF PRE-ECLAMPSIA OF PREGNANT FEMALES - Raised total plasma FVII protein, including activated FVII (FVIIa) in pregnant females, compared with total plasma FVII protein in normal pregnancy, has been found to be an indicator of the pregnancy complication of pre-eclampsia. | 2011-09-29 |
20110236909 | LASER SCANNING CYTOMETRY MEDIATED ANALYSIS OF THERAPEUTIC EFFICACY IN TUMORS - This invention describes the use of a laser scanning device, for example a laser scanning CYTOMETRY (LSC), with a double-fluorescent labeling technique as a quantitative method that can be used to objectively and accurately measure endothelial cell death, endothelial tumor cell death and blood vessel density of tumor tissue. These parameters can be used as markers of efficacy in tumors treated with anti-angiogenic or traditional therapies and can distinguish patients who respond to these drugs from those who do not. | 2011-09-29 |
20110236910 | PROSTATE CANCER BIOMARKER - The present invention relates to the field of prostate cancer. Particularly the invention relates to villin as a novel prostate biomarker. The invention further relates to compositions comprising anti-villin antibodies and use of these compositions for an improved detection of prostate cancer in a subject. | 2011-09-29 |
20110236911 | Precipitating Substrate for Bio-Layer Interferometry - Improved apparatus, compositions, and methods for carrying out interferometry-based assays for detecting analytes in a sample through the use of a precipitating substrate to enhance an interferometry binding signal, and kits useful for carrying out these assays. Methods comprise providing an optical assembly comprising an optical element with a transparent material and adapted for coupling to a light source via a fiber, a first reflective surface and a second reflecting surface having a first analyte-binding molecule and separated from said first surface by a distance, d, exposing said optical element to a sample comprising said analyte, a second analyte binding molecule, and a precipitating substrate; and detecting a change in thickness at said first reflective surface thereby detecting said analyte in said sample. Kits include reagents for derivatizing assay components along with packaging and instructions for use. | 2011-09-29 |
20110236912 | SYSTEMS AND METHODS FOR CHARACTERIZING LUPUS ERYTHEMATOSUS - The present invention provides systems and methods for characterizing biological markers in the urine of systemic lupus erythematosus (SLE) subjects. In particular, the present invention relates to the detection of cytokines and chemokines in urine of SLE subjects for determining nephritic disease states and kidney damage in SLE subjects and the efficacy of agents and interventions used to treat lupus nephritis. | 2011-09-29 |
20110236913 | COMPOSTION AND KIT FOR DIAGNOSING IMMUNOGLOBULIN A NEPHROPATHY AND TGBM NEPHROPATHY - Disclosed is the development of a protein used as a biomarker for diagnosing IgA nephropathy and TGBM (thin-glomerular-basement-membrane) using urine through a target proteomics method. The disclosed development relates to a diagnosis biomarker protein and a kit for diagnosing IgA nephropathy and TGBM and predicting progress of the nephropathy in advance using the protein. The protein level is increased or decreased in urine from a patient with IgA nephropathy or TGBM nephropathy compared to urine from a normal patient. According to the disclosed development, the degree of the disease can be grasped by detecting IgA nephropathy and TGBM, enabling early diagnosis and confirming progress from the patient's urine. In addition, a monoclonal antibody produced based on the diagnosis biomarker protein can be used for an immunoassay kit (ELISA, antibody coated tube test, lateral-flow test, potable biosensor). As well, the monoclonal antibody is used in early diagnosis and progress detection of IgA nephropathy and development of a novel drug for the purpose of treatment. | 2011-09-29 |
20110236914 | RECORDING ASSAY DEVICE - A method for assaying a sample involves an assessment device having an assay part and a detachable recording part, which are disposed on separable portions of a substrate. The sample to be assayed is received in a sample application well on the assay element, where it contacts a measuring element, generally after being mixed with an assay reagent. Assay information relating to the sample is transferred from the measuring element to data recording element on the recording part. After the information transfer, the assay part and the recording are separated, so that the assay part can no longer transfer information to the data recording element. | 2011-09-29 |
20110236915 | ZAP-70 EXPRESSION AS A MARKER FOR CHRONIC LYMPHOCYTIC LEUKEMIA / SMALL LYMPHOCYTIC LYMPHOMA (CLL/SLL) - It has been surprisingly found that ZAP-70 expression, both at the protein and mRNA levels, is indicative of clinical subgroups of CLL/SLL patients. In particular, high ZAP-70 expression is indicative of Ig-unmutated CLL/SLL. Methods are provided for discriminating between clinical subgroups of CLL/SLL, by determining whether subjects overexpress ZAP-70 mRNA mRNA or protein. | 2011-09-29 |
20110236916 | METHODS AND MATERIALS FOR DETECTING COLORECTAL NEOPLASM - The present invention provides methods and materials related to the detection of colorectal neoplasm-specific markers in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals having a colorectal neoplasm by detecting the presence of exfoliated epithelial markers (e.g., human DNA, tumor associated gene alterations, tumor associated proteins) and blood markers (e.g., homoglobin, serum proteins) in a stool sample obtained from the mammal. | 2011-09-29 |
20110236917 | Diagnosis of Alzheimer's Disease - Embodiments of an assay for the screening, diagnosis, and differentiation of Alzheimer's disease uses selected sets of serum protein biomarkers. The assay is used to distinguish Alzheimer's disease from Parkinson's disease, other neurodegenerative diseases, and normal controls. Specific sets of serum protein biomarkers are identified for the diagnosis of Alzheimer's disease in drug naïve and drug treated patients. | 2011-09-29 |
20110236918 | METHODS FOR CONDUCTING GENETIC ANALYSIS USING PROTEIN POLYMORPHISMS - Methods and processes for conducting genetic analysis through protein polymorphisms, including identification of individuals, establishment of paternity and measurement of genetic diversity and distance. Some illustrative embodiments of methods of the present invention include the identification of peptide biomarkers using proteomic techniques, including liquid chromatography-tandem mass spectrometry from biological samples, using hair, dentin, or bone as a source of the protein to be analyzed. Other illustrative embodiments include the determination of allelic frequency and feasibility of protein polymorphism peptide biomarkers, and the application of these frequencies to allow statistical analysis and population genetics to be applied to collected biological samples. | 2011-09-29 |
20110236919 | PROCESS FOR RESTRICTING CARBON MONOXIDE DISSOLUTION IN A SYNGAS FERMENTATION - A process to temporarily and selectively control the dissolved concentration of CO in the feed medium portion of a fermentation liquid by addition of a surface tension active compound (STAC), particularly during seed train scale-up operations and during recovery from process upsets, to support improved production of biofuels from a syngas fermentation. The process inoculates the fermentation liquid when the cell density level is from 0.05 to 0.5 OD with the surface tension active compound at a concentration of from 20 to 800 mg per liter of syngas fermentation liquid. The surface tension active compound may be a polyol or glycol. | 2011-09-29 |
20110236920 | NOVEL VARIANTS OF PQQ-DEPENDENT GLUCOSE DEHYDROGENASE HAVING IMPROVED SUBSTRATE SPECIFICITY - The invention relates to novel PQQ-dependent soluble glucose dehydrogenases (sPQQGDH) which have an increased substrate specificity compared with the wild type, and also to methods for production and identification thereof. | 2011-09-29 |
20110236921 | CELL SYSTEM - The present invention relates to cellular systems for testing drug candidates and for evaluating the function of mitochondrial proteins. The invention is particularly useful for evaluating drug candidates for cancer and for conducting studies on drug resistance. | 2011-09-29 |
20110236922 | METHOD TO DETERMINE STATE OF A CELL EXCHANGING METABOLITES WITH A FLUID MEDIUM BY ANALYZING THE METABOLITES IN THE FLUID MEDIUM - The present invention relates to a method for determining the ideal time for and outcome of reproductive health procedures including in vitro fertilization by establishing a correlation between the successful outcome of said procedure and the spectra of a body fluid obtained using a chosen analytical modality for a population of patients, acquiring for a patient a spectrum of the body fluid of the patient using said chosen modality. | 2011-09-29 |
20110236924 | SYSTEM AND METHOD FOR PROCESSING SAMPLES - A system and method for processing samples. The system can include a loading chamber, a detection chamber positioned in fluid communication with the loading chamber, and a fluid path defined at least partially by the loading chamber and the detection chamber. The system can further include a filter positioned such that at least one of its inlet and its outlet is positioned in the fluid path. The method can include positioning a sample in the loading chamber, filtering the sample in the fluid path to form a concentrated sample and a filtrate, removing the filtrate from the fluid path at a location upstream of the detection chamber, moving at least a portion of the concentrated sample in the fluid path to the detection chamber, and analyzing at least a portion of the concentrated sample in the detection chamber for an analyte of interest. | 2011-09-29 |
20110236925 | Method of Obtaining a Purified, Biologically Active Heterologous Protein - The invention relates to methods of separation and/or purification of impurities yielding a purified heterologous protein product devoid of related impurities or with substantially minimal quantities of such glycosylated impurities. More specifically, the invention relates to the identification of glycosylated forms of insulin analogues such as glargine impurities characterized post expression in yeast based systems such as | 2011-09-29 |
20110236926 | Host Cells and Methods Of Producing Disulfide Bond Containing Proteins - The invention provides for genetically modified | 2011-09-29 |
20110236927 | GENETICALLY STABILIZED TANDEM GENE DUPLICATION - The invention provides constructs and methods for producing genetically stabilized tandem gene duplications. | 2011-09-29 |
20110236928 | Methods for producing polypeptides in enzyme-deficient mutants of fusarium venenatum - The present invention relates to methods of producing a polypeptide, comprising: (a) cultivating a mutant of a parent | 2011-09-29 |
20110236929 | E. COLI BL21 STRAIN LACKING A FUNCTIONAL GROUP II CAPSULAR GENE CLUSTER - The present invention relates to a novel non-pathogenic | 2011-09-29 |
20110236930 | CHEMOSELECTIVE LIGATION - The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety, or which can be engineered to comprise a cleavable linker so that a substituent of the phosphine is transferred to the azide, releasing an oxidized phosphine byproduct and producing a native amide bond in the final product. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids). | 2011-09-29 |
20110236931 | CHEMICAL AND BIOCHEMICAL ADDUCTS AS BIOMARKERS FOR ORGANOPHOSPHATE EXPOSURE - Provided is a method to identify OP-adducted biomarkers of OP exposure as well as compounds containing OPs that can provide OP adducts. | 2011-09-29 |
20110236932 | BIOPHARMACEUTICAL PLANT IN A COLUMN - The present invention relates to a series of therapeutic material processing devices stacked into a column, hereby creating a bio material process plant with extremely small foot-print and all the processing devices being of single-use capabilities for lowest possible cost and methods of operating said column. | 2011-09-29 |
20110236933 | RECOMBINANT EUKARYOTIC EXPRESSION PLASMID ENCODING pprI GENE OF DEINOCOCCUS RADIODURANS R1 AND ITS FUNCTIONS - The present invention concerns a novel recombinant eukaryotic expression plasmid pCMV-HA-pprI encoding the pprI gene isolated from | 2011-09-29 |
20110236934 | PRODUCTION OF GLOBOSIDES OLIGOSACCHARIEDS USING METABOLICALLY ENGINEERED MICROORGANISMS - The present invention relates to the large scale in vivo synthesis of globosides oligosaccharides; especially globotriose, globotetraose and globopentaose, which are the carbohydrate portions of globotriosylceramide (Gb3Cer), globotetraosylceramide (Gb4Cer) and globopentaosylceramide (Gb5Cer) respectively. It also relates to high yield production of potential anticancer vaccines of the globo-series glycosphingo lipids, including the Globo-H. It also relates to the use of the glycosyltransferase encoded by the lgtD gene from | 2011-09-29 |
20110236935 | OXIDATION PROCESS - A method of oxidising a saccharide, by contacting the saccharide with an alcohol dehydrogenase (ADH) enzyme selected from a quinone redox cofactor-dependent ADH, a nicotinamide adenine dinucleotide (NAD | 2011-09-29 |
20110236936 | METHOD FOR ENHANCING PRODUCTION POLYHYDROXYALKANOIC ACID FROM MICROORGANISM STRAINS - Provided is a method for enhancing the production of polyhydroxyalkanoic acid (PHA) from microorganism strains by disrupting a gene associated with the production of an exobiopolymer (EBP) in the | 2011-09-29 |
20110236937 | Multi-Stage Fermenter Nutrient Feeding - A method for operating a fermenter system. In one instances, the method comprises flowing biomass and liquid in opposite directions through a fermenter train comprising a plurality of fermenters, and introducing a nutrient to any of the plurality of fermenters to optimize the production carboxylate products in the fermenter system. | 2011-09-29 |
20110236938 | BIOFUEL PRODUCTION - Methods, enzymes, recombinant microorganism, and microbial systems are provided for converting polysaccharides, such as those derived from biomass, into suitable monosaccharides or oligosaccharides, as well as for converting suitable monosaccharides or oligosaccharides into commodity chemicals, such as biofuels. Commodity chemicals produced by the methods described herein are also provided. Commodity chemical enriched, refinery-produced petroleum products are also provided, as well as methods for producing the same. | 2011-09-29 |
20110236939 | BIOFUEL PRODUCTION - Methods, enzymes, recombinant microorganism, and microbial systems are provided for converting polysaccharides, such as those derived from biomass, into suitable monosaccharides or oligosaccharides, as well as for converting suitable monosaccharides or oligosaccharides into commodity chemicals, such as biofuels. Commodity chemicals produced by the methods described herein are also provided. Commodity chemical enriched, refinery-produced petroleum products are also provided, as well as methods for producing the same. | 2011-09-29 |
20110236940 | Method of Preparing Piceatannol Using Bacterial Cytochrome P450 and Composition Therefor - Provided is a method of preparing piceatannol, and more particularly, to a method of preparing piceatannol from resveratrol using bacterial cytochrome P450 BM3 (CYP102A1) or mutants thereof, and a composition and a kit therefor. | 2011-09-29 |
20110236941 | RECOMBINANT MICROORGANISM AND METHODS OF PRODUCTION THEREOF - A novel genetically modified microorganisms capable of using CO to produce 1-butanol and/or a precursor thereof, novel methyltransferases and nucleic acids encoding same, methods for producing genetically modified microorganisms using said novel methyltransferases, and methods of producing 1-butanol and/or a precursor thereof by microbial fermentation. | 2011-09-29 |
20110236942 | Reduced by-product accumulation for improved production of isobutanol - The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of 3 keto-acid (e.g., acetolactate and 2-aceto-2-hydroxybutyrate) and/or aldehyde-derived by-products. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the | 2011-09-29 |
20110236943 | BIOPROCESSING LIGNO-CELLULOSE INTO ETHANOL WITH RECOMBINANT CLOSTRIDIUM - The present invention relates, inter alia, to recombinant Gram-positive Clostridia host cells for producing solvents, fuels and/or chemical intermediates, and preferably ethanol, from plant cell walls comprising: (a) at least one nucleic acid encoding a plant cell wall degrading enzyme, wherein the host cells produce and secrete the plant cell wall degrading enzyme, (b) at least one nucleic acid encoding an enzyme that converts pyruvate to acetaldehyde and at least one nucleic acid encoding an enzyme that converts acetaldehyde to ethanol wherein the host cell is capable of expressing said nucleic acid, and, (c) a mutation in at least one nucleic acid encoding for an enzyme in a metabolic pathway which produces a metabolite other than acetaldehyde from pyruvate or ethanol from acetaldehyde, such that the mutation results in a reduced production of the metabolite. | 2011-09-29 |
20110236944 | METHOD FOR PRODUCING INTERMEDIATE MATERIAL INTENDED FOR ETHANOL PRODUCTION, AND RESULTING INTERMEDIATE MATERIAL - A process for the production of an intermediate product from a lignocellulosic raw material that is intended for the production of ethanol, which process includes pulping the raw material in an extruder at a temperature of between 60° C. and 180° C., in the presence of a quantity of water that represents between 200% and 450% of the mass of the raw material and preferably in the presence of a strong acid or a strong base that is weakly concentrated. An intermediate product can be obtained by this process for producing ethanol. | 2011-09-29 |
20110236945 | USE OF RECYCLED COTTON FOR PRODUCING ETHANOL, AND PRODUCTION METHOD - Recycled textile cotton is used for producing ethanol by the execution of a process that includes a) a stage of pretreatment of textile cotton, optionally with grinding of textile cotton, pretreatment of textile cotton that may or may not be ground by pulping | 2011-09-29 |
20110236946 | Concurrent Anaerobic Digestion and Fermentation of Lignocellulosic Feedstocks - A process for concurrent production of lignins, fuel alcohol, and biogas from lignocellulosic feedstocks. The process comprises: (1) pretreating a lignocellulosic feedstock to produce a solubilised liquid components stream comprising lignins, lignin-derived compounds, and a cellulosic pulp stream, (2) separating the liquid stream from the cellulosic pulp stream, (3) processing the liquid stream to separate and recover at least lignins, lignin-derived compounds, and semi-solid waste material, (b) processing the cellulosic pulp stream to saccharify and ferment the cellulose pulp to produce a beer which is then separated into fuel-grade alcohol and a waste stillage material, (4) anaerobically digesting the semi-solid waste material from the liquid stream and the waste stillage material to produce a biogas. The rate of anaerobic digestion can be manipulated by controllably supplying a portion of the monosaccharides produced from the cellulosic pulp. The cellulosic pulp stream may also be anaerobically digested. | 2011-09-29 |
20110236947 | Reducing methane slack when starting and stopping biogas fermenters - A novel method reduces methane slack when operating a biogas fermenter. When starting up a freshly charged fermenter, the methane portion of the produced biogas is initially so low and the portions of carbon dioxide and nitrogen are so high that the biogas cannot be directly used in a combined heat and power plant. Conventionally, the biogas generated during the startup phase has a small portion of methane that is discharged directly into the atmosphere or is flared off if the methane fraction is larger. The initially produced methane is consequently not used and becomes methane slack. To reduce methane slack, the biogas with the low methane fraction is fed to a gas treatment unit in which non-methane components of the gas mixture are partially separated, and the remaining gas mixture with a higher methane content is returned to the biogas fermenter until the methane fraction is sufficiently high. | 2011-09-29 |
20110236948 | MAGNETIC PATTERNING METHOD AND SYSTEM - The present invention relates to a method and apparatus for patterning a substrate. The method comprises providing at least one magnetic pattern generator configured and operable to modulate the magnetic field to induce varying magnetic properties to a magnetic field according to a desired pattern; applying the modulated magnetic field in the vicinity of the substrate creating a certain pattern of regions of interaction to be obtained on top of the substrate; and; interacting the substrate with magnetic particles, while under the application of the modulated magnetic field, the magnetic particles being attracted to selected regions of interaction defined by the certain pattern while being substantially not attracted to regions outside the regions of interaction, thus creating on top of the substrate the certain pattern of regions interacted with the magnetic particles. The desired pattern corresponds to a certain pattern for a predetermined magnetic field profile and at a predetermined distance from the magnetic pattern generator, where the sample is to be located. | 2011-09-29 |
20110236949 | Methods for Processing Biological Tissues - Methods are provided for removing or separating the cellular and/or soluble macromolecular component of a biological tissue from the extracellular matrix component of the biological tissue, comprising embedding the biological tissue in an electrically conductive semi-solid or solid supporting medium and applying an electric field to the tissue-medium complex. Additionally, methods are provided for decellularizing a skin fragment. | 2011-09-29 |
20110236950 | GRG23 EPSP SYNTHASES: COMPOSITIONS AND METHODS OF USE - Compositions and methods for conferring herbicide resistance or tolerance to bacteria, plants, plant cells, tissues and seeds are provided. Compositions include polynucleotides encoding herbicide resistance or tolerance polypeptides, vectors comprising those polynucleotides, and host cells comprising the vectors. The nucleotide sequences of the invention can be used in DNA constructs or expression cassettes for transformation and expression in organisms, including microorganisms and plants. Compositions also include transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated polynucleotides encoding glyphosate resistance or tolerance polypeptides are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated polynucleotides containing nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, or 35, or the nucleotide sequence set forth in SEQ ID NO:6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, or 34. | 2011-09-29 |
20110236951 | Biocomposite materials and methods for making the same - A particle (and a composition that includes a plurality of the particles) that includes at least one polypeptide molecule and at least one polymer covalently bound to the polypeptide molecule so as to form a polymer shell substantially encompassing the polypeptide molecule, wherein the particle does not define a dimension greater than about 1 μm. One example for making the particle includes modifying the polypeptide molecule to provide α, β-ethylenically unsaturated terminal functional groups, mixing the modified polypeptide molecule with a silicon-containing polymerizable compound, and subjecting the resulting mixture to conditions sufficient for polymerizing the polymerizable compound to form the particle. | 2011-09-29 |
20110236952 | NOVEL SUBSTRATES OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE AND MUTANTS THEREOF - The invention relates to compounds of formula (I′): | 2011-09-29 |
20110236953 | EMBRYONIC CEREBROSPINAL FLUID (e-CSF), PROTEINS FROM e-CSF, AND RELATED METHODS AND COMPOSITIONS - We have performed a proteomic analysis of embryonic cerebrospinal fluid (e-CSF) in human and rats. Based on this discovery, the invention features methods and compositions for cell culture including components of e-CSF or fragments thereof. Also provided are methods for extraction of e-CSF. | 2011-09-29 |
20110236954 | CELLULASE PRODUCTION METHOD BASED ON THE REGULATION OF THE DISSOLVED OXYGEN PRESSURE OSCILLATION IN THE CULTURE MEDIUM - The present invention relates to a method of producing cellulolytic and/or hemicellulolytic enzymes by a cellulolytic microorganism in a stirred and aerated bioreactor, comprising a growth stage in the presence of a carbon source and a production stage in the presence of a carbon-containing inductive substrate, wherein the supply of carbon-containing inductive substrate during the production stage is regulated by an oscillation of the dissolved oxygen partial pressure in the medium. | 2011-09-29 |
20110236955 | ARYLACYLAMIDASE GENE AND METHOD OF USING THE SAME - The present invention provides an efficient method of producing an arylacylamidase. In an aspect, the present invention provides (a) a DNA comprising the base sequence shown in the sequence listing under SEQ ID NO:1, or (b) a DNA capable of hybridizing, under stringent conditions, with a DNA comprising the base sequence complementary to the base sequence shown in the sequence listing under SEQ ID NO:1 and coding for a polypeptide having arylacylamidase activity. In another aspect, the invention provides a polypeptide encoded by the DNA mentioned above and having arylacylamidase activity, a vector containing the DNA mentioned above, a transformant which is transformed using the DNA or the vector mentioned above, and a method for producing an arylacylamidase which comprises cultivating the transformant mentioned above and obtaining the arylacylamidase from the culture medium. | 2011-09-29 |
20110236956 | MULTICISTRONIC siRNA CONSTRUCTS TO INHIBIT TUMORS - Multicistronic short interfering RNA constructs targeting in various combinations a human urokinase-type plasminogen activator receptor (uPAR), human urokinase-type plasminogen activator (uPA), human matrix metalloprotease 9 (MMP-9) and cathepsin B (CB) inhibit tumors. | 2011-09-29 |
20110236957 | Nanoparticle Labeling Reagents and Methods of Use - Compositions and methods for labeling biological targets using a conjugate of a luminescent component and a targeting molecule attached to a nanoparticle core structure are described. The labeling conjugates offer high intensity and low background, and are ideal for histology and pathology. | 2011-09-29 |
20110236958 | Multistory Bioreaction System for Enhancing Photosynthesis - The present invention relates to a multistory system for using waste carbon dioxide and waste heat to facilitate cultivation of photosynthetic organisms. In particular, the present invention relates to a multistory system with the incorporation of upconverting and downconverting luminescent materials and other components suitable for enhancing growth of photosynthetic organisms. | 2011-09-29 |
20110236959 | METHOD OF MANUFACTURING PLANAR BIO-TEST STRIP AND PRODUCT THEREOF - A planar bio-test strip includes a carrier plate, a conductive circuit formed on the carrier plate by evaporation, a testing electrode terminal and an electrode circuit terminal formed at front and rear ends of the conductive circuit respectively, and an enzyme reacting area coupled to a front end of the testing electrode terminal. A manufacturing method of the planar bio-test strip includes (1) using a plastic film as a carrier plate, and constructing a shadow mask by printing; (2) evaporating the carrier plate printed with the shadow mask to form a conductive electroplated layer; (3) removing a block of the conductive electroplated layer covered by the shadow mask by a physical method to expose the conductive circuit; (4) setting an enzyme in an enzyme reacting area; (5) attaching a cover film; such that the test strip can be mass produced with low costs, and enhanced quality, stability and market competiveness. | 2011-09-29 |
20110236960 | APPARATUS AND METHODS FOR INTEGRATED SAMPLE PREPARATION, REACTION AND DETECTION - Cartridges for the isolation of a biological sample and downstream biological assays on the sample are provided. In one embodiment, a nucleic acid sample is isolated from a biological sample and the nucleic acid sample is amplified, for example by the polymerase chain reaction. The cartridges provided herein can also be used for the isolation of non-nucleic acid samples, for example proteins, and to perform downstream reactions on the proteins, for example, binding assays. Instruments for carrying out the downstream biological assays and for detecting the results of the assays are also provided. | 2011-09-29 |
20110236961 | SYSTEMS AND METHODS FOR TREATING LANDFILL GAS USING LANDFILL LEACHATE - Embodiments of the present invention are directed to systems and methods for treating landfill gas using landfill leachate. In one embodiment of the present invention, a method includes receiving landfill leachate from at least one of a plurality of sources, and pretreating the landfill leachate to adjust at least one chemical property of at least one component of the landfill leachate. The leachate contacts landfill gas, so that at least one component of the landfill gas chemically reacts with at least one component of the landfill leachate to form a spent landfill leachate and a treated landfill gas. The method also includes recycling a first portion of the spent landfill leachate, recirculating a second portion of the spent landfill leachate to at least one of the plurality of sources, and subjecting the treated landfill gas to flare. | 2011-09-29 |
20110236962 | Calibratable sensor unit for reaction vessels - The present invention relates to a calibratable sensor unit for a reaction vessel, such as for example a fermenter ( | 2011-09-29 |
20110236963 | SYSTEM AND METHOD FOR ANALYTE MEASUREMENT - A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed. | 2011-09-29 |
20110236964 | DNA Sequencing System - An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector. | 2011-09-29 |
20110236965 | PANELIZED DRUM SYSTEM - A rotating drum that is made from a plurality of panels that are connected to form sub-cylinders that, in turn, are connected to form a drum cylinder. Drum heads are connected at both ends of the drum cylinders. The drum may be rotated using rotational means. In one preferred embodiment the rotational means is a tangential rotational drive system that engages drive tires that are positioned between sub-cylinders. A method for fabricating rotating drums. A business method of mass production of and/or distribution of rotating drums. | 2011-09-29 |
20110236966 | SINGLE LENTIVIRAL VECTOR SYSTEM FOR INDUCED PLURIPOTENT (IPS) STEM CELLS DERIVATION - The present invention is based on the discovery that a single lentiviral vector expressing multiple individual transcription factor proteins from a single multi-cistronic mRNA can reprogram a fibroblast cell to a stem cell-like cell. These reprogrammed induced pluripotent stem (iPS) cells are pluripotent. Additions of the Cre-LoxP sequences into the single lentiviral vector facilitate excision of the vector after reprogramming in achieved. Addition of a maker gene into the single lentiviral vector facilitates detection of the presence of the vector in an iPS. The invention provides compositions and methods of producing iPS cells using a single multi-cistronic lentiviral vector. | 2011-09-29 |
20110236967 | PROMISCUOUS HER-2/NEU CD4 T CELL EPITOPES - The present invention relates to the discovery of novel T cell epitopes of the human HER-2/Neu protein that is promiscuous for at least 25 different HLA-DR alleles. The invention also relates to compositions that contain one of the novel epitopes or a fusion peptide of such a epitope and a heterologous polypeptide. Further disclosed herein is the use of the epitopes or their fusion peptides, and compositions containing the epitopes or their fusion peptides. | 2011-09-29 |
20110236968 | HUMANIZED ANTIBODIES AGAINST MONOCYTE CHEMOTACTIC PROTEINS - The invention provides humanized antibodies that bind to a plurality of β-chemokines, particularly monocyte chemotactic proteins MCP-1, MCP-2 and MCP-3. The invention also provides therapeutic reagents and methods of treating disorders associated with detrimental MCP activity. | 2011-09-29 |
20110236969 | METHODS OF GENERATING VARIANT PROTEINS WITH INCREASED HOST STRING CONTENT AND COMPOSITIONS THEREOF - The present invention relates to novel methods for generating variant proteins with increased host string content, and proteins that are engineered using these methods. | 2011-09-29 |
20110236970 | CHAMBER OF A BIOREACTOR PLATFORM - Disclosed herein is mesoscale bioreactor platform comprising an upwards open chamber for a biological cell, which chamber via a first port is in communication with a first channel for conducting an influent stream of a liquid into the chamber and via a second port is in communication with a second channel for conducting an effluent stream of a liquid away from the chamber, which chamber is provided with a closure comprising a water-immiscible liquid, and wherein said first channel is in fluid communication with a reservoir for a liquid and said second channel is in fluid communication with a waste container. Furthermore, a method for modifying the interaction of a content of a chamber with the surroundings is described as well as method of culturing a biological cell. | 2011-09-29 |
20110236971 | Generation of Clonal Mesenchymal Progenitors and Mesenchymal Stem Cell Lines Under Serum-Free Conditions - Methods for obtaining multipotent Apelin receptor-positive lateral plate mesoderm cells, mesenchymal stem cells, and mesangioblasts under serum-free conditions are disclosed | 2011-09-29 |
20110236972 | NUCLEIC ACID COMPOUNDS FOR INHIBITING BIRC5 GENE EXPRESSION AND USES THEREOF - The present disclosure provides RNA molecules, for example, meroduplex ribonucleic acid molecules (mdRNA), capable of decreasing or silencing BIRC5 gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a BIRC5 mRNA. Also provided are methods of decreasing expression of a BIRC5 gene in a cell or in a subject to treat a BIRC5-related disease. | 2011-09-29 |
20110236973 | Centrosome proteins and uses thereof - The invention includes nucleic acids and polypeptides that play important roles in centrosomes and cellular functions involving centrosomes. In addition, the invention encompasses antibodies, ribozymes, antisense nucleic acids, RNAis, and siRNAs that can be used to modulate the function of the nucleic acids and polypeptides of the invention. Such modulation can be useful in detecting, diagnosing, and treating abnormal centrosome function. | 2011-09-29 |
20110236974 | COMPOSITIONS AND METHODS FOR MAKING AND USING LAMININ NANOFIBERS - The present invention provides methodologies and parameters for fabrication of the hybrid biomaterial by blending pure laminin or complex extracts of tissues containing laminin with biopolymers such as polycaprolactone (PCL), polylactic/polyglycolic acid copolymer (PLGA) or Polydioxanone (PDO) in fluoroalcohols (HFP, TFA), fabrication of substrates and scaffolds and devices from the hybrid biomaterial in forms such as films, nanofibers by electrospinning or microspheres, and the biological or biomedical use of the material or devices derived from it. | 2011-09-29 |
20110236975 | GROWTH FACTOR WHICH ACTS THROUGH ERB B-4 RTK - The present invention provides for isolated polypeptides capable of binding ErbB-4. | 2011-09-29 |
20110236976 | VECTOR COMPRISING MULTIPLE HOMOLOGOUS NUCLEOTIDE SEQUENCES - The invention relates to vectors comprising two or more homologous nucleotide sequences and methods for generating them. The invention concerns substituting bases in the homologous nucleotide sequences with different bases that do not alter the encoded amino acid sequence. The invention allows for the reduction of intramolecular recombination between homologous nucleotide sequences, in particular in mammalian cells. The invention further relates to nucleotide sequences containing substituted bases. | 2011-09-29 |
20110236977 | DENTAL STEM CELL DIFFERENTIATION - Provided is a method of preparing an embryonic stem cell-like cell, a method of preparing an insulin-secreting cell or pancreatic beta-like cell, a method of preparing a chondrocyte-like cell, a method of preparing a myocyte-like cell, and a method of preparing a hair follicle-like cell. A composition comprising a dental stem cell and an insulin-secreting cell or a pancreatic beta-like cell is also provided. Further, a composition comprising (a) a dental stem cell and (b) a chondrocyte-like cell, a myocyte-like cell, or a hair follicle-like cell is provided. Additionally provided is an insulin-secreting cell or a pancreatic beta-like cell differentiated from a dental stem cell. Further provided is a chondrocyte-like cell, a myocyte-like cell, or a hair follicle-like cell, derived from a dental stem cell. | 2011-09-29 |
20110236978 | REPROGRAMMING CELLS TOWARD A PLURIPOTENT STATE - The present invention relates to a process for preparing reprogrammed cells, in particular for preparing pluripotent and multipotent stem cells and to the pluripotent and multipotent stem cells prepared by said processes. | 2011-09-29 |