40th week of 2009 patent applcation highlights part 56 |
Patent application number | Title | Published |
20090246740 | METHODS AND APPARATUS TO PROVIDE TRAINING AGAINST IMPROVISED EXPLOSIVE DEVICES - Method and apparatus for a training system for improvised explosive devices (IEDs). An IED training system can include an inert explosive component that can resemble a large round, rocket propelled grenade (RPG), or the like. Various triggers can activate visual and/or audio devices in response to triggering the system, such as by a motion sensor or trainer action. | 2009-10-01 |
20090246741 | MODULAR FLIGHT CONTROL STRUCTURE - A flight control structure for supporting various components of a flight simulator. The flight control structure includes a plurality of elongated members, the plurality of elongated members being adapted to receive a plurality of connectors for connecting the plurality of elongated members and for mounting a plurality of components of the flight simulator. One or more of the plurality of connectors are movable and/or removable so that the flight control structure assumes a first flight simulator configuration adapted to simulate a first aircraft or a second flight simulator configuration adapted to simulate a second aircraft. | 2009-10-01 |
20090246742 | Interactive Storytelling Kit & Method - An interactive play kit comprising at least one changeable setting, at least one representative object, a primary cue-card containing a fixed outline of a story adapted for development of a primary story, and at least one secondary cue-card containing guidelines adapted for development of a secondary story being a variation of the primary story. The aforementioned at least one representative object is adapted to be movably placed and displaced within the at least one changeable setting so as to convey either the primary story or the secondary story. | 2009-10-01 |
20090246743 | LANGUAGE LEARNING SYSTEM AND METHOD THEREOF - A language learning system and a method thereof are disclosed. The language learning system comprises at least one teaching material database and a computer apparatus. The teaching material database comprises original video data, original broadcast sequence data and authored learning data. The computer apparatus comprises a language learning module, a text record table and a broadcast rule table. The language learning module has an index module, a broadcast module and a recording module. The index module compares the original broadcast sequence data with the text record table to generate a broadcast sequence table. At least one learning unit is generated from the original video data or the authored learning data based on the broadcast sequence table. The broadcast module broadcasts the learning unit based on the broadcast rule table. In addition, the computer apparatus can automatically download the broadcast rule table, the learning unit and the language learning module to a portable video broadcast apparatus. | 2009-10-01 |
20090246744 | METHOD OF READING INSTRUCTION - A method of automatically generating personalized text for teaching a student to learn to read. Based upon inputs of the students reading ability/level, either from a self assessment or teacher input and input of personal data, the system automatically searches selected libraries and chooses appropriate text and modifies the text for vocabulary and topics of character identification of personal interest to the student. An optional function of previewing by one of the student's teacher, parent or advocate is included. The system generates a local repository of generated text associated with a particular student. | 2009-10-01 |
20090246745 | System and method for guiding next step adaptive behavior - The system and method of the present invention process clarified emotional response data in order to guide next step adaptive behavior. Emotional responses with predetermined clarified intensities are sorted. The best quality clarified intensity or intensities are then selected as the ‘heart of the matter’, which is then shown to a user to reveal how the user is most uniquely responding to a particular subject or issue. The user is then given guidance on how to respond to the particular subject or issue thereby guiding the user's behavior in response to such subject or issue. | 2009-10-01 |
20090246746 | DEVICE AND METHOD FOR DISPLAYING TARGET INDICATIONS FOR FOOT MOVEMENTS TO PERSONS WITH A WALKING DISORDER - A walking-trainer device for persons with a walking disorder to relearn walking has a movable tread surface and a display unit for displaying target indications of the corresponding and consecutive foot positions for movements made by a person walking on the tread surface. The target indications have the form of a number of consecutive patterns located above a target surface at the height of and in the longitudinal direction of the tread surface moving in the direction of the person, which visibly move from a distance of between 0.5 m and 0.5 m, preferably between 15 m and 5 m and more preferably between 0.7 m and 2.5 m, from the target surface in the direction of and over the tread surface up to the feet of the person. The speed of movement of the patterns is substantially equal to the speed of movement of the tread surface. | 2009-10-01 |
20090246747 | SIMULATOR FOR MAJOR SURGICAL OPERATIONS - The invention consists of a hands-on, physically simulated human or animal body interior, containing physically simulated representations of all of the solid organs, hollow viscera, bladders, glands, major ducts, large and medium-sized blood vessels, muscle groups and interstitial tissues. The organs and vessels are life-sized and are composed of molded or sculpted open cell or closed cell foam rubber of varying density and load deformation, matching the physical properties of the specific biologic organs or tissues simulated. The organs, tissues and vessels may be treated with pigments, sealants and/or hardening agents to reflect the contours, appearances, densities, textures, elasticity, and deformability of normal or pathologically-altered internal organs and tissues. Organs contain molded vascular channels, reversibly attached to the larger blood vessels of the simulator. The model has a pressurized, watertight, simulated vascular system, monitored by electronic sensors. | 2009-10-01 |
20090246748 | Device and method for teaching the concept of elapsed time - The device for teaching the concept of elapsed time is an educational tool for teaching children the concept elapsed time, and how to understand the passage of time, with emphasis on particular time intervals, such as hourly intervals or portions of the day, and activities associated therewith. The device includes an elongated strip having longitudinally opposed first and second ends. The elongated strip further has opposed front and rear surfaces, and a first set of graduated demarcations is formed on the front surface. A first set of indicia are formed on the front surface adjacent the first set of graduated demarcations, with the first set of demarcations and the first set of indicia representing hours of the day. The first set of indicia represents the hours in the form of “1:00 P.M.” or “12:00 A.M”, for example. The first and second ends are preferably joined together to form a loop. | 2009-10-01 |
20090246749 | INTERACTIVE STORYTELLER SYSTEM - The interactive storyteller system ( | 2009-10-01 |
20090246750 | Devices and Methods for Collection, Storage and Transportation of Biological Specimens - The present invention provides methods for collecting, storing or transporting liquid suspension of biological specimens containing analytes of interest in a dry state. The dried biological specimens containing analytes of interest are reconstituted and released for subsequent analysis by compressing or centrifuging the matrix. Also provided are method of using kits for collecting, storing, transporting and recovering biological specimens containing analytes of interest. | 2009-10-01 |
20090246751 | METHOD FOR THE DETECTION OF VIRUS INFECTED CELLS - The present invention relates to a method for determining one or more stressed cell(s) in a medium. The method comprises the steps of (i) providing a sample from the medium, and (ii) determining a change in the sample relative to a normal sample of non-stressed cell(s). | 2009-10-01 |
20090246752 | APPARATUS AND METHOD FOR DETECTING MICROSCOPIC LIVING ORGANISMS USING BACTERIOPHAGE - A method for detecting one or more target bacteria in a raw sample where: 1) bacteriophage(s) specific to each target bacterium are added to the raw sample, 2) the test sample is incubated, and 3) the test sample is tested for the presence of each phage in sufficient numbers to indicate the presence of the associated target bacteria in the raw sample. In one embodiment, each phage is initially added to the raw sample in concentrations below the detection limit of the final phage detection process. In another embodiment, the parent phages are tagged in such a way that they can be separated from the progeny phage prior to the detection process. Preferred phage detection processes are immunoassay methods utilizing antibodies that bind specifically to each phage. Antibodies can be used that bind to the protein capsid of the phage. Alternatively, the phage can by dissociated after the incubation process and the sample tested for the presence of individual capsid proteins or phage nucleic acids. The invention can be used to test target bacteria for antibiotic resistance. | 2009-10-01 |
20090246753 | Detection of Phage Amplification by SERS Nanoparticles - A phage specific antibody presenting particle, devices and methods related to detection of phage amplification are provided. | 2009-10-01 |
20090246754 | OPTIMIZED PROBES AND PRIMERS AND METHODS OF USING SAME FOR THE DETECTION AND QUANTITATION OF BK VIRUS - Described herein are probes and primers for detecting and quantitating variant BK viral strains and methods and devices of identifying and using the described probes and primers. | 2009-10-01 |
20090246755 | Method of examining chemical using gene-disrupted strain - A method having higher sensitivity in a bioassay method utilizing cell response of a microorganism, for detecting the presence of a chemical in a test specimen is provided. The method of the present invention is characterized in that it uses specified gene-disrupted strains. | 2009-10-01 |
20090246756 | Thermostable polypeptide having polynucleotide kinase activity and/or phosphatase activity - Isolated polypeptides having 5′-kinase and/or 3′-phosphatase activity and temperature optimum of at least 60° C. are described. The invention also relates to isolated nucleic acids encoding the polypeptides, nucleic acid constructs and host cells comprising the nucleic acid sequences as well as methods using the polypeptides and kits for practicing the methods. | 2009-10-01 |
20090246757 | Method, Program, and System for Normalizing Gene Expression Amounts - The present invention aims at presenting novel means for analyzing and correcting gene expression amounts. There is provided a gene expression amount normalizing method in which the number of cells in a sample is obtained by measuring a repeated sequence present in a substantially fixed proportion in a genome contained in the sample, and the number of cells obtained is used as an index for normalizing gene expression amounts obtained from the same sample. For example, a DNA sample | 2009-10-01 |
20090246758 | Peptide nucleic acid probes for analysis of microorganisms - The instant invention provides PNA probes for detection, identification and/or quantitation of microorganisms, e.g., | 2009-10-01 |
20090246759 | TEST AND MODEL FOR INFLAMMATORY DISEASE - The present invention relates to a means and methods for determining susceptibility to SEEK1 mediated diseases, such as psoriasis. In addition, there is provided polynucleotides encoding the SEEK1 protein having one or more nucleotide insertions, deletions or substitutions at one or novel positions, and the SEEK1 protein having one or more amino acid insertions, deletions and substitutions. Host cells and transgenics non-human animals comprising polynucleotides or proteins of the invention are also provided. Methods of screening for agents for use in treating SEEK1 mediated disease are also provided. | 2009-10-01 |
20090246760 | METHODS OF EQUALIZING REPRESENTATION LEVELS OF NUCLEIC ACID TARGETS - The disclosure provides methods of reducing the range of representation levels of nucleic acid targets. The methods are particularly useful for multi-target analyses benefiting from a low variance of target representations, such as, e.g., single molecule sequencing and/or heterozygous genotyping, and pathogen diagnosis. Two general methods are provided. In Method 1, starting concentrations of probes are adjusted. In Method 2, target-specific probes are “binned,” i.e., several subsets of probes are selected based on similar representation levels. Thereafter, each subset of corresponding targets is extracted, with or without amplification, using a separate portion of the sample (i.e., separate vessels). | 2009-10-01 |
20090246761 | DEVELOPMENT OF PROGNOSTIC MARKERS FROM THE SALIVA OF HEAD AND NECK CANCER PATIENTS - The present invention relates to biomarkers that are useful for the detection of cancer. The invention further relates to biomarkers and methods of using biomarkers for the early detection of head and neck cancer. | 2009-10-01 |
20090246762 | NUCLEIC ACID TERMINATORS INCORPORATING A CATIONIC MOIETY AND METHODS FOR THEIR USE - Disclosed are methods and kits applicable to sequencing methods, such as Sanger dideoxy sequencing methods. The methods and kits disclosed utilize a cationically charged nucleic acid terminator in combination with a discriminatory polymerase. | 2009-10-01 |
20090246763 | ELECTROCHEMICAL LABELS DERIVED FROM SIDEROPHORES - Disclosed are tri-nuclear metal complexes and salts thereof, such as tri-nuclear osmium or ruthenium complexes or salts thereof, suitable for use as electrochemical labels. Also disclosed are oligonucleotide probes with an attached electrochemical label, methods of nucleic acid amplification, methods of sequencing, and kits for nucleic acid amplification and sequencing having oligonucleotide probes including an electrochemical label. The electrochemical labels are synthesized from siderophores. | 2009-10-01 |
20090246764 | Method for the detection of group B Streptococcus (GBS) (Streptococcus agalactiae) in mammals - A method for the detection of all strains of Group B Streptococcus (GBS) ( | 2009-10-01 |
20090246765 | METHOD AND DEVICE FOR DETECTING TARGET SUBSTANCE USING PROBE CARRIER - A detecting device for detecting an enzyme present on a predetermined location on a substrate using a luminescence reaction, includes a mounting stage for mounting the substrate, a spotting means for locally applying a micro-droplet substance which contributes to a luminescence reaction with the enzyme onto a predetermined location on the substrate, and a detecting means for detecting a luminescence signal generated by applying the substance based on the timing of discharging a liquid droplet. | 2009-10-01 |
20090246766 | High throughput screening of genetically modified photosynthetic organisms - The present invention provides a method and compositions for high throughput screening of genetically modified photosynthetic organisms for plasmic state. The present invention provides methods of producing one or more proteins, including biomass degrading enzymes in a plant. Also provided are the methods of producing biomass degradation pathways in alga cells, particularly in the chloroplast. Single enzymes or multiple enzymes may be produced by the methods disclosed. The methods disclosed herein allow for the production of biofuel, including ethanol. | 2009-10-01 |
20090246767 | Compositions and methods for detecting Cryptococcus neoformans - Disclosed are oligonucleotides useful in methods for determining whether a sample contains | 2009-10-01 |
20090246768 | Predicting and Diagnosing Patients With Autoimmune Disease - The present invention provides methods for the prediction and diagnosis of autoimmune diseases, including Systemic Lupus Erythematosus, by identifying polymorphisms in the gene for MECP2. | 2009-10-01 |
20090246769 | MOLECULAR DIAGNOSIS OF OVARIAN CANCERS - A molecular diagnosis system of ovarian cancers encompasses a detection device configured to obtain a detected value of an expression amount of an apolipoprotein A1 gene in ovarian tissue as a diagnosis subject, a storage device configured to store a normal value of the expression amount of the apolipoprotein A1 gene in normal ovarian tissue, and a determination mechanism configured to determine that the ovarian tissue as the diagnosis subject is clear cell adenocarcinoma when the detected value is lower than the normal value. | 2009-10-01 |
20090246770 | GLYCEMIC CONTROL FOR REDUCTION OF CARDIOVASCULAR DISEASE RISK IN DIABETIC PATIENTS EXPRESSING HAPTOGLOBIN 2-2 - This invention relates to methods of reducing risk of developing cardiovascular complications in diabetic patients. Specifically, the invention relates to the use of haptoglobin genotyping for determining the importance of maintaining tight glycemic control in diabetic subjects expressing Hp 2-2 allele. | 2009-10-01 |
20090246772 | NOVEL DIBENZO[c,h][1,5]NAPHTHYRIDINES AND THEIR USE AS DNA PROBES - The present invention concerns novel dibenzo[c,h][1,5]naphthyridine of formula (I) and their use as DNA probes, as well as the methods for marking DNA using the same. | 2009-10-01 |
20090246773 | DIAGNOSTIC COMPOSITIONS AND TREATMENT METHODS FOR CONDITIONS INVOLVING TROPHOBLAST CELL DEATH, DIFFERENTIATION, INVASION AND/OR CELL FUSION AND TURNOVER - The invention provides a method for diagnosing in a subject a condition requiring modulation of or involving trophoblast cell death, differentiation, invasion, and/or cell fusion and turnover, comprising detecting HIF Iα and the factors which modulate or are modulated by this protein, specifically TGFβ3, sFLT, VEGF, SMAD2, 3 and 7, MtdP, MtdL, MclI 1, MclIc, VHL, SiahI, Siah2, ENG, and PHD. The invention also provides a method for diagnosing or distinguishing in a subject a specific condition requiring modulation of or involving trophoblast cell death, differentiation, invasion, and/or cell fusion and turnover, in particular early onset severe preeclampsia (EPE), late onset preeclampsia (LPE) and mtre-uterme growth restriction (IUGR) comprising detecting HLF Iα and the factors which modulate or are modulated by this protein as defined above. | 2009-10-01 |
20090246774 | Chromosomal Blocks as Markers for Traits - The present invention provided a method for predicting a phenotype in a bovine animal, the method comprising analysing a nucleic acid sample from said animal for the presence of at least one genetic marker known to reside in an Linkage Disequilibrium (LD) block in any one of bovine chromosomes BTA-I to BTA-29, wherein said LD block is associated with said phenotype. The phenotype can be Australia profit ranking (APR), Australian selection index (ASR), protein yield (PROT), protein percent (PROT %), milk volume (MILK), fat yield (FAT), fat percent (FAT %), breeding value overall type (Overall Type), somatic cell count (SCC), and/or breeding value cow fertility (Cow Fertility). Also provided is a linkage disequilibrium unit (LDU) map of any one or more of bovine chromosomes BTA-I to BTA-29, the map comprising a plurality of chromosomal regions, and the regions defined by their co-inheritance across generations substantially as entire linkage disequilibrium (LD) blocks. | 2009-10-01 |
20090246775 | PROBE, PROBE SET, PROBE-IMMOBILIZED CARRIER, AND GENETIC TESTING METHOD - A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 65 to 67 or a combination of at least two of them is used for detecting the gene of an infectious disease pathogenic bacterium. | 2009-10-01 |
20090246776 | Modulators of scarb-1 for treating acne or hyperseborrhea - An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of the SCARB-1 receptor, and the use of modulators of the expression or activity of this receptor for the treatment of acne or skin disorders associated with a hyperseborrhea; methods for the in vitro diagnosis or prognosis of these pathologies are also described. | 2009-10-01 |
20090246777 | ALLELIC DISCRIMINATION ANALYSIS USING AN EFFICIENCY RELATED VALUE (EFR) - In various embodiments this invention provides novel methods for discriminating two or more different target nucleic acids. In certain embodiments the methods comprise providing data amplification reactions comprising reagents to amplify two or more different target nucleic acids where the data comprise signals comprising an amplitude measurement representing the degree of amplification of each target nucleic acid in the amplification reaction and the time point in the amplification reaction at which the amplitude is measured; determining an efficiency related transform of the data, determining an efficiency related value for each target nucleic acid that is the maximum magnitude of the efficiency related transform; and outputting the efficiency related values in the amplification reaction for each target nucleic acid, where the relative amplitudes of the efficiency related values for each target nucleic acid is an indicator of the presence of each of said nucleic acids in said sample. | 2009-10-01 |
20090246778 | IDENTIFICATION OF FAT AND LEAN PHENOTYPES IN CHICKENS USING MOLECULAR MARKERS - The present invention identifies genetic markers for lean and fat phenotypes in chickens and provides methods of screening chickens to determine those more likely to have a lean or fat phenotype. The invention also provides methods of screening chickens to identify a polymorphism in THRSPα associated with a fat or lean phenotype. | 2009-10-01 |
20090246779 | INCREASING GENOMIC INSTABILITY DURING PREMALIGNANT NEOPLASTIC PROGRESSION REVEALED THROUGH HIGH RESOLUTION ARRAY-CGH - The present invention relates to a method of diagnosing a premalignant condition based on the presence of chromosomal alterations at one or more fragile chromosome sites. Methods of determining chromosomal alterations are disclosed. The present invention also relates to methods of establishing a prognosis and a therapeutic regimen for the subject having the premalignant condition are also disclosed. | 2009-10-01 |
20090246780 | HIGH THROUGHPUT PHYSICAL MAPPING USING AFLP - The present invention relates to a high throughput method for the identification and detection of molecular markers wherein restriction fragments are generated and suitable adaptors comprising (sample-specific) identifiers are ligated. The adapter-ligated restriction fragments may be selectively amplified with adaptor compatible primers carrying selective nucleotides at their 3′ end. The amplified adapter-ligated restriction fragments are, at least partly, sequenced using high throughput sequencing methods and the sequence parts of the restriction fragments together with the sample-specific identifiers serve as molecular markers. | 2009-10-01 |
20090246781 | Method for early determination of recurrence after therapy for prostate cancer - This invention describes compositions and methods for use in PSA assays having low functional sensitivity which are useful, for example, in the detection of early stage recurrence of prostate disease following treatment and in the determination of whether patients have early stage biochemical reoccurrence (ES-BCR) or stable disease. | 2009-10-01 |
20090246782 | BARRIERS FOR FACILITATING BIOLOGICAL REACTIONS - The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes. | 2009-10-01 |
20090246783 | METHOD OF MEASURING PYROPHOSPHATE - Provided is a novel and useful method of measuring pyrophosphate in a sample. There may be provided a novel and useful method of measuring pyrophosphate in a sample using pyruvate orthophosphate dikinase, nicotinamide-nucleotide adenylyltransferase, and dehydrogenase. | 2009-10-01 |
20090246784 | METHOD OF ANALYZING METHYLATED DNA - The present invention provides a method of analyzing methylated DNA, comprising steps of: (A) treating a DNA-containing sample with a restriction enzyme to obtain a sample containing a DNA fragment; (B) concentrating methylated DNA contained in the sample obtained in step (A) to obtain a methylated DNA concentrate; (C) subjecting the methylated DNA concentrate obtained in step (B) and a primer set to nucleic acid amplification reaction, wherein the primer set performs the nucleic acid amplification reaction in step (C) by using a template DNA which does not have a CpG site; (D) detecting an amplification product obtained in step (C); (E) judging whether the methylated DNA concentrate obtained in step (B) is appropriate as a sample for detection of methylated DNA, on the basis of the detection result of the amplification product in step (D); and(F) analyzing the methylated DNA contained in the methylated DNA concentrate. | 2009-10-01 |
20090246785 | NOVEL STEROID 5-ALPHA-REDUCTASE - The invention provides an isolated, novel steroid 5α-reductase enzyme termed SRD5AIII. The protein has an estimated molecular weight of 37 kDa and is capable of converting testosterone to dihydrotestosterone at a pH of about 7.0. Also provided is a method for identifying inhibitors of SRD5AIII by contacting SRD5AIII with a test compound and measuring the activity of the enzyme. A reduced activity relative to a control indicates that the test compound is an inhibitor of SRD5AIII. A method is also provided for detecting androgen stimulated prostate cancer or recurrent prostate cancer in an individual. The method comprises obtaining a prostate biopsy from an individual and determining the level of expression of SRD5AIII gene or protein relative to a normal control. An increased expression of SRD5AIII relative to the control is indicative of androgen stimulated prostate cancer or recurrent prostate cancer. | 2009-10-01 |
20090246786 | NOVEL RAT VOLTAGE-GATED POTASSIUM CHANNEL - Disclosed herein are nucleic acid and polypeptide sequences of a novel rat voltage-gated potassium channel, KCNQ5. Also disclosed herein are methods related to the use of the aforementioned potassium channel. | 2009-10-01 |
20090246787 | METHOD AND APPARATUS FOR DETERMINING CHEMOSENSITIVITY - A method for determining chemosensitivity of a malignant tumor cell to anthracycline is described herein. According to this method, first tumor cell and second tumor sell are first prepared. The first tumor cell is not treated with anthracycline, and on the other the second tumor cell is treated with anthracycline. Secondly, first and second activity levels of CDK1 are measured. The first activity level is activity of CDK1 in the first tumor cell and the second activity level is that of CDK1 in the second tumor cell. Finally, chemosensitivity of the malignant tumor cell is determined. The determination is based on the first and second activity levels. | 2009-10-01 |
20090246788 | Methods and Assays for Capture of Nucleic Acids - The present disclosure provides methods and systems for sequence specific nucleic acid target capture comprising enzymatic reactions. The present disclosure relates to a plurality of oligonucleotide probes for capture and subsequent detection of target nucleic acid sequences, using flap endonucleases, ligases, and/or additional enzymes, proteins or compounds, on substrates, for example microarray slides, and in solution formats. | 2009-10-01 |
20090246789 | Gene Mutation Profiling of CSMD1 - A method for assessing risk of node-positive colorectal cancer in an individual is described. The method includes detecting mutations in CSMD1 genes in a tumor sample from the individual, the mutations being associated with increased risk of node-positive colorectal cancer. | 2009-10-01 |
20090246791 | ENGINEERED FLUORESCENT DYE LABELED NUCLEOTIDE ANALOGS FOR DNA SEQUENCING - Engineered nucleotide compositions, having polymerase interacting components that improve the interactivity of the polymerase and the nucleotide, particularly for nucleic acid sequencing applications. Compositions include the interactive polymerases along with the nucleotide analogs. Kits, methods and systems are provided for analysis of nucleic acid synthesis reactions. | 2009-10-01 |
20090246792 | METHODS FOR DETECTING NUCLEIC ACID SEQUENCE VARIATIONS - The invention employs an unlabeled signal primer comprising a 5′ adapter sequence for detection of variations in nucleic acid target sequences. The detection system further comprises a reporter probe, the 3′ end of which hybridizes to the complement of the 5′ adapter sequence of the signal primer to produce a 5′ overhang. Polymerase is used to fill in the overhang and synthesize the complement of the 5′ overhang of the reporter probe. Synthesis of the reporter probe complement is detected, either directly or indirectly, as an indication of the presence of the target. | 2009-10-01 |
20090246793 | CUDR AS BIOMARKER FOR CANCER PROGRESSION AND THERAPEUTIC RESPONSE - Disclosed is a novel human gene designated CUDR. Provides is also a CUDR gene as a biomarker in the diagnosis of human cancers and a cancer therapy. | 2009-10-01 |
20090246794 | Methods and Kit for Detecting Breast Cancer - The present inventions relates to kits and methods for diagnosing and monitoring breast cancer. An increase in the level or activity of proteins of the ubiquitin/proteasome pathway, and ancillary proteins thereof, as compared to normal control or benign tissue is indicative of breast cancer. | 2009-10-01 |
20090246795 | IMMUNOASSAY DEVICE AND METHOD - An immunoassay device capable of assaying amount of an antigen by allowing a labeled antibody to specifically bind to a antigen analyte in a sample and assaying a label of a bound product, an interior of a single device has four regions comprises: (1) a first region where the antigen in the sample reacts with a first antibody that is the labeled antibody capable of specifically binding to the antigen, (2) a second region where first antibody that has not bound to the antigen reacts with a second biotin- or avidin-bound antibody, (3) a third region where, depending on whether the second antibody is biotin-bound antibody or avidin-bound antibody, either avidin or biotin is immobilized by immobilization means so as to be unable to move to the fourth region, and the second antibody is captured by the immobilized avidin or biotin, and (4) a fourth region where the label of the first antibody that has bound to the antigen is detected, being constructed in such a way that a solution can move sequentially through each region, the first antibody, which is the labeled antibody such that an antibody component is an F(ab′) fragment or reduced IgG, the F(ab′) fragment or reduced IgG being bound with the label in a predetermined proportion, is included in the first region or an adjacent region, and the second antibody is a biotin- or avidin-bound antibody, being of anti-idiotype antibody against the first antibody and a type that cannot bind to the bound product of the antigen and first antibody, and is included in the second region or an adjacent region. | 2009-10-01 |
20090246796 | ISOLATION AND ENUMERATION OF CELLS FROM A COMPLEX SAMPLE MATRIX - The present invention relates to methods and systems for labeling, isolating, detecting and enumerating biological cells, or other biological analytes of interest present in a sample, where the capturing complex may also serve as a labeling agent. In one embodiment, the capture complex is an encoded magnetic bead coupled to antibodies having a specific affinity for a cell surface protein on a cell of interest. The methods and systems of the present invention can be used for quantitative or qualitative detection. | 2009-10-01 |
20090246797 | MEDICAL DEVICE FOR THE ASSESSMENT OF INTERNAL ORGAN TISSUE AND TECHNIQUE FOR USING THE SAME - A system for tissue ischemia detection is provided that may be used to assess markers of tissue ischemia. Such a system may include a sensor that may be used directly on internal tissue to assess ischemic condition. Sensors to be used in conjunction with the provided system may include optical, chemical or electrochemical sensors that may be directly applied or affixed to the tissue, held proximate to the tissue, or spread over the tissue in the form of a gel. | 2009-10-01 |
20090246798 | METHOD OF DETECTING CANCER AND EVALUATING CANCER PROGNOSIS - A method of detecting cancer in a subject is provided. One step of the method includes obtaining a bodily sample from the subject. Next, the level of pro-prion protein (pro-PrP) in the bodily sample is detected. The level of pro-PrP in the bodily sample is then compared to a control level. An increased level of pro-PrP in the bodily sample as compared to the control level indicates that the subject has cancer or an elevated risk of having cancer. | 2009-10-01 |
20090246799 | Detection of Chronic Kidney Disease Patients or Coronary Artery Disease Using Bone Morphogenic Protein-4 - The invention is a method of detecting CAD in a CKD diagnosed human patient or CKD in a diagnosed CAD patient, or detection the presence of both CDK and CAD by assaying a plasma or serum sample of a human patient for elevated levels of BMP-4. | 2009-10-01 |
20090246800 | IMMUNOASSAY OF ANALYTES IN SAMPLES CONTAINING ENDOGENOUS ANTI-ANALYTE ANTIBODIES - The disclosure provides among other things an assay method that compensates for the presence of endogenous antibodies, e.g., autoantibodies, which might otherwise compromise the measurement of an analyte in a biological sample. In one embodiment, this method entails the use of a two labeled entities: a labeled detection agent and a labeled species-specific antibody, wherein the labeled species-specific antibody is specific for the species from which the biological sample was obtained. Sample analyte is bound by the detection agent and any anti-analyte autoantibodies present in the sample. Analyte bound by autoantibodies is detected via the species-specific antibody, optionally labeled. | 2009-10-01 |
20090246801 | RAPID TEST FOR GLYCATED ALBUMIN IN BLOOD - This invention describes a rapid assay for measuring the ratio of glycated albumin to total albumin in blood. Patients with diabetes have elevated levels of glucose in their blood that can react with plasma albumin to form glycated albumin. The amount of glycated albumin formed is directly correlated with the level of plasma glucose that the albumin has been exposed to over a period of time. The ratio of glycated albumin to total albumin in blood will provide an indication of the average amount of protein glycation that occurred over the preceding 2-3 week period. | 2009-10-01 |
20090246802 | ANNEXIN-BASED APOPTOSIS MARKERS - The present invention describes an annexin derivative and a method of using the annexin derivative as a biosensor for real-time visualization of phosphatidylserine exposure, apoptosis, live-cell imaging and monitoring of cell health. | 2009-10-01 |
20090246803 | NAD BIOSYNTHESIS SYSTEMS - The present invention generally relates to a nicotinamide adenine dinucleotide (NAD) biosynthesis system and methods of screening for NAD biosynthesis effectors. Among the various aspects of the present invention is the provision of an in vitro-reconstituted mammalian NAD biosynthesis system that can be used for the high-throughput screening of chemical activators and inhibitors for mammalian NAD biosynthesis. Another aspect of the invention provides a method of identifying a compound that effects in vivo activity of NAD metabolic enzymes. Further aspects of the invention include nucleic acid sequences, vectors, and transformed cells that can be used in the methods described herein. | 2009-10-01 |
20090246804 | Immuno gold lateral flow assay - A chromatographic specific binding assay strip device, comprising: a non-permeable platform strip; a permeable membrane testing strip positioned on top of said non-permeable platform strip, with the testing strip comprising at least one capture reagent site containing a capture reagent for at least one specific analyte, a sample receiving pad positioned on top of and at a proximal end of the non-permeable platform strip, with the sample receiving pad having contact with a proximal end of said permeable membrane testing strip, a reservoir pad positioned on top of and at a distal end of said non-permeable membrane testing strip, with the reservoir pad having contact with a proximal end of said permeable membrane test strip; a supporting strip attached to and extending from the proximal end of said non-permeable platform strip; and a conjugate pad positioned on said supporting strip, said conjugate pad comprising a semi-permeable membrane containing a colorant conjugate. The semi-permeable membrane acts as a barrier between the conjugate pad and the sample receiving pad, regulating the flow through the semi-permeable membrane and overall flow of the assay. By dipping the conjugate pad into a sample solution, there will be increased binding between the analyte in the sample and the conjugate (preferably colloidal gold), thereby giving improved results on the lateral flow assay. | 2009-10-01 |
20090246805 | METHOD FOR CLASSIFYING AND COUNTING BASOPHILS - A method for counting basophils which comprises: (1) mixing and reacting a blood sample with an anti-CD123 antibody labeled with a first fluorescent label and an anti-CD294 antibody labeled with a second fluorescent label to prepare a measurement sample, (2) introducing the measurement sample into a flow cell of a flow cytometer and irradiating, with light, cells in the measurement sample flowing in the flow cell, (3) detecting fluorescences from the first and second fluorescent labels as well as two scattered lights different in angle, emitted from the cells, (4) identifying basophils on the basis of the detected fluorescences from the first and second fluorescent labels as well as the two scattered lights different in angle, and (5) counting the identified basophils. A kit for measuring basophils which comprises a CD123 antibody labeled with a first fluorescent label and a CD294 antibody labeled with a second fluorescent label. | 2009-10-01 |
20090246806 | COCCIDIOIDES ANTIGEN IMMUNOASSAY - The present disclosure relates to methods for detecting a | 2009-10-01 |
20090246807 | Method for quantitative measurements of HDL-C and LDL-C - The present invention relates to a method for direct measurement of high-density lipoprotein cholesterol. (HDL-C) or low-density lipoprotein cholesterol (LDL-C) based on a modified chemical precipitation method, wherein the improvements were made by optimizing the concentrations and proportions of potassium polyvinyl sulfate (PVSK) and polyethylene glycol methyl ether (PEGME) in such a way that the enzymatic reactions are completed before precipitation formations. The method in combination with certain surfactants showed good correlations with other direct methods used for HDL-C or LDL-C determinations. | 2009-10-01 |
20090246808 | BIOSENSOR WITH IMPROVED ANALYTE SPECIFICITY - A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5. | 2009-10-01 |
20090246809 | METHOD OF SUPPORTING A DIAGNOSIS OF A RISK OF CANCER RECURRENCE, AND A DEVICE OF SUPPORTING A DIAGNOSIS OF A RISK OF CANCER RECURRENCE - A method of supporting a diagnosis of a risk of cancer recurrence is disclosed. The method provides a new determining value a recurrence risk score (RRS) which is calculated based on expression levels and activity values of two cyclin dependent kinases (CDKs). The risk of cancer recurrence is judged by comparing the RRS with a predetermined threshold level for RRS. | 2009-10-01 |
20090246810 | Use of MRP 8/14 levels for discrimination of individuals at risk of acute coronary syndromes - The present invention relates to a method for determining the risk whether an individual showing at least one symptom of an evolving acute coronary syndrome (ACS) is suffering from an acute coronary syndrome comprising the steps of (a) measuring, preferably in vitro, the level of MRP 8/14, wherein (b) if the level of MRP 8/14 is at least increased, then the individual is at risk of suffering from an acute coronary syndrome. The invention further relates to methods for ruling out whether an individual showing at least one symptom of an evolving ACS is suffering from an ACS, for assessing whether an individual showing at least one symptom of an evolving ACS is not at risk of suffering from an ACS and to discriminate if an individual showing at least one symptom of an evolving ACS is at risk to suffer from an ACS and or has no ACS. | 2009-10-01 |
20090246811 | DRY ANALYTICAL ELEMENT FOR LIPASE MEASUREMENT - The present invention provides a method for producing a dry analytical element for measurement of pancreatic lipase contained in a body fluid which contains triglyceride of long chain alkyl fatty acid having 12 to 22 carbon atoms, monoglyceride lipase, and a glycerine measurement reagent, and comprises a water-impermeable support and at least one spreading or reagent layer, said method comprising the step of coating an emulsion/dispersion solution of triglyceride with an average particle size of 1 μm or less. | 2009-10-01 |
20090246812 | DRY ANALYTICAL ELEMENT FOR LIPASE MEASUREMENT - It is an object of the present invention to provide: a dry analytical element for analyzing pancreatic lipase wherein the triglyceride is not transcribed on the support to contaminate a transportation slip or other analytical elements and wherein an additive solution of the triglyceride neither reaggregates nor precipitate, so that the dry analytical element is stable and is compatible with production. The present invention provides a dry analytical element for measuring pancreatic lipase contained in body fluid, which comprises triglyceride of long chain alkyl fatty acid having 12 to 22 carbon atoms, monoglyceride lipase, and a glycerin measurement reagent, and which comprises a water-impermeable support and at least one spreading or reagent layer, wherein a hydrophilic polymer at a weight ratio of 1.8:1 or greater with respect to the triglyceride is contained. | 2009-10-01 |
20090246813 | SELECTIVE ACCELERATION OF FRAGMENTATION THROUGH JOINT APPLICATION OF ENZYMES AND ULTRASOUND - The present invention refers to an acceleration process for macromolecular fragmentation in liquid medium, in gel or in a solid support, by means of joint application of enzymes and ultrasounds, as well as isotopes. The macromolecules, in any of these liquids, are mixed with enzymes and inserted in a recipient ( | 2009-10-01 |
20090246814 | REAGENT FOR DIGESTION OF HEMOGLOBIN - The present invention relates to a reagent for digestion of hemoglobin comprising a buffer, pepsin and a | 2009-10-01 |
20090246815 | PROTEASE DETECTION MATERIAL, SET OF PROTEASE DETECTION MATERIALS, AND METHOD FOR MEASURING PROTEASE - The present invention provides a protease detection material having, on a support, at least a layer containing a dye precursor and a layer which contains a protease substrate and is disposed on the same side of the support as the layer containing the dye precursor and farther from the support than the layer containing the dye precursor, wherein the layer containing the protease substrate further contains a development center-forming substance. Further, a set of protease detection materials and a method for measuring protease using the above-described protease detection material are provided. A protease detection material, a set of protease detection materials, and a method of measuring protease which allow protease activity to be measured promptly with high sensitivity, and that allow, at the same time, morphological observation of tissues and cells on a thin film to be performed easily. | 2009-10-01 |
20090246816 | METHODS AND KITS FOR SELECTING AN ANALGESIC REGIME - A method is provided for selecting an analgesic regime for treatment of a patient. In the method, a body fluid sample from the patient is assayed for the presence of a metabolite produced by metabolism of a prodrug. If the metabolite is present in the body fluid sample this indicates that a suitable analgesic regime for the patient should comprise administration of at least one analgesic agent selected from the group consisting of: codeine and tramadol. If the metabolite is absent from the body fluid sample indicates that a suitable analgesic regime for the patient should comprise administration of an analgesic agent selected from the group consisting of: dihydrocodeine; buprenorphine and propoxyphene. The invention also provides a kit for selecting an analgesic regime for a patient. The kit comprises means for assaying for the presence of a metabolite produced by metabolism of a prodrug and instructions for using the provided means to perform the method as described above. | 2009-10-01 |
20090246817 | DRY ANALYTICAL ELEMENT CAPABLE OF REDUCING INFLUENCE OF HEMOLYSIS FOR BODY FLUID COMPONENT MEASUREMENT - It is an object of the present invention to reduce influence of hemolysis in a dry analytical element used for measurement of components in a body fluid sample such as blood. The present invention provides a method for producing a dry analytical element for body fluid component measurement comprising at least a reagent layer containing an H | 2009-10-01 |
20090246818 | COMPOUNDS, METHODS, COMPLEXES, APPARATUSES AND USES RELATING TO STABILE FORMS OF NAD/NADH - The invention concerns stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives, enzyme complexes of these derivatives and their use in biochemical detection methods and reagent matrices. | 2009-10-01 |
20090246819 | Assay Methods Using Chemiluminescent Detection of Peroxidase - Methods for generating chemiluminescence rapidly by reaction of at least one compound comprising a C—C double bond substituted at one carbon with two sulfur atom-containing groups with a peroxidase enzyme and a peroxide are disclosed. The chemiluminescence thus produced can be used as a detectable signal in assays for peroxidase enzymes or peroxide-producing enzymes and in assays employing enzyme-labeled specific binding pairs. Use of the methods provides rapid signal generation, achieving a plateau intensity in under one minute. The substrate can be provided in a composition which demonstrates unexpectedly long storage stability. | 2009-10-01 |
20090246820 | COMPOUNDS USEFUL IN CFTR ASSAYS AND METHODS THEREWITH - The present invention relates to compounds useful in CFTR assays. The present invention also relates to compounds useful in monitoring CFTR activity in therapies for CFTR-mediated diseases. The present invention also provides an assay for use in measuring CFTR correction. | 2009-10-01 |
20090246821 | PEROXIREDOXIN DRUGS FOR TREATMENT OF HIV-1 INFECTION AND METHODS OF USE THEREOF - The invention includes compositions comprising substantially purified peroxiredoxin that are useful in methods for the treatment and prevention of HIV-1 infection. The invention also includes methods for the treatment and prevention of HIV-1 infection comprising contacting a composition of the invention with a human patient. Additionally, the invention includes antibodies and kits useful in the treatment and prevention of HIV-1 infection. | 2009-10-01 |
20090246822 | Composition for cell permeabilization comprising NOG, HMP, rubidium chloride and/or lithium chloride for detecting living cells on a membrane - The present invention relates to a composition for the permeabilization of the walls of microorganisms comprising the combination of octyl-β-D-glucopyranoside (NOG), sodium polyphosphates (HMP), and a salt chosen from lithium chloride or rubidium chloride, and a method for the enumeration and identification of cells on a membrane using said composition. | 2009-10-01 |
20090246823 | EVALUATION METHODOLOGY OF THE PROTECTION CHARACTERISTICS OF PERSONAL PROTECTIVE EQUIPMENTS AGAINST BIOLOGICAL AGENTS - New testing methodology for the evaluation of the protection of the Personal Protective Equipments (PPE) for the respiratory tract against biological agents, characterized in that different machineries are used to reproduce the usage of the PPE, simulating a breathing through the Sheffield's head and self-respirator. The apparatus consists of: a) a viral and/or bacterial aerosol generator b) a test chamber containing the Sheffield's head c) a respirator simulating breathing and adjusting the inspiration and expiration frequency d) a suction system delivering the samples of air withdrawn in different points to the bubblers to determine the viral and/or bacterial concentrations. | 2009-10-01 |
20090246824 | Methods for Integrated Tissue Processing and Staining - Methods that combine processing and staining of tissue samples such that the processed tissue is stained and ready for histological evaluation prior to embedding and sectioning, and separate staining of the sectioned tissue is not required. The method may be used with chemical and/or mechanical/thermal tissue penetrant enhancers in an automated tissue processing system. | 2009-10-01 |
20090246825 | Method for Processing a Tissue Specimen In Situ Prior to Histological Examination - The present invention is directed to a method for processing a tissue specimen in situ prior to histological examination by providing a tissue specimen having a predetermined examination face, disposing the specimen on a tissue positioning member for removably maintaining the tissue specimen with the examination face in a desired orientation thereon, processing the tissue specimen while maintaining the examination face in the desired orientation on the positioning member throughout processing, separating the tissue specimen from the tissue positioning member by application of a separation force, and maintaining the orientation of the examination face after the specimen is removed from the tissue positioning member wherein processing of the specimen includes contacting the specimen with fluids for dehydrating and clearing the specimen and subsequent casting of the specimen in an embedding material for forming a specimen-containing mold portion having the tissue specimen contained therein in desired orientation. | 2009-10-01 |
20090246826 | Bi-Directional Selection Markers With Improved Activity - The present invention discloses a polypeptide selected from the group consisting of: a polypeptide having an amino acid sequence according to SEQ ID NO 3, a polypeptide having an amino acid sequence according to SEQ ID NO 6, a polypeptide having an amino acid that is substantially homologous to the sequence of SEQ ID NO 3 and a polypeptide having an amino acid that is substantially homologous to the sequence of SEQ ID NO 6, the polypeptide displaying acetamidase activity and providing a reverse selection on fluoroacetamide with an efficiency of at least 95%, preferably at least 96%, more preferably at least 97%, more preferably at least 98%, more preferably at least 99%, most preferably 100%. The gene encoding the polypeptide of the invention is used as an efficient bi-directional selection marker in the construction of selection marker free strains, in particular for processes for the production of a compound of interest. | 2009-10-01 |
20090246827 | RECOMBINANT TOXIN FRAGMENTS - A single polypeptide is provided which comprises first and second domains. The first domain enables the polypeptide to cleave one or more vesicle or plasma-membrane associated proteins essential to exocytosis, and the second domain enables the polypeptide to be translocated into a target cell or increases the solubility of the polypeptide, or both. The polypeptide thus combines useful properties of a clostridial toxin, such as a botulinum or tetanus toxin, without the toxicity associated with the natural molecule. The polypeptide can also contain a third domain that targets it to a specific cell, rendering the polypeptide useful in inhibition of exocytosis in target cells. Fusion proteins comprising the polypeptide, nucleic acids encoding the polypeptide and methods of making the polypeptide are also provided. Controlled activation of the polypeptide is possible and the polypeptide can be incorporated into vaccines and toxin assays. | 2009-10-01 |
20090246828 | Arabinose Isomerase Expressed from Corynebacterium Genus and Tagatose Manufacturing Method by Using It - The present invention relates to a thermophilic arabinose isomerase and a method of manufacturing tagatose using the same, and more precisely, a gene encoding arabinose isomerase originating from the thermophile | 2009-10-01 |
20090246829 | SEQUENCE ANALYSIS OF THE TETRAVALENT ROTAVIRUS VACCINE - Isolated nucleic acid molecules comprising a gene segment from a rhesus rotavirus (RRV) or from one of three rhesus:human reassortant viruses are disclosed, including isolated nucleic acid molecules having a sequence selected from the group consisting of: SEQ ID NO: 1-14, inclusive, and isolated nucleic acid molecules encoding a protein having a sequence selected from the group consisting of SEQ ID NO: 15-28, inclusive, as well as variants of the isolated nucleic acid molecules. | 2009-10-01 |
20090246830 | RECOMBINANT INFLUENZA VIRUSES FOR VACCINES AND GENE THERAPY - A method for producing influenza virus particles for preparation of a vaccine. The method comprises growing reassortant influenza viruses to produce virus particles and recovering the produced virus particles. The reassortant influenza viruses are produced in cultured cells in the absence of helper virus by introducing into the cultured cells expression vectors sufficient to produce genomic vRNA or antigenomic vRNA (cRNA) segments in the cells of reassortant influenza viruses. The method produces a nucleoprotein and an RNA dependent RNA polymerase in the cells so that RNP complexes containing the genomic vRNA segments of the reassortant influenza viruses are formed. The method uses expression vectors containing HA, NA, non-HA and non-NA vRNA segments in which the HA and NA vRNA segments are HA and NA vRNA segments of a viral strain different from a strain that contains all of the non-HA and non-NA vRNA segments. | 2009-10-01 |
20090246831 | Methods for Recombinant Peptide Production - The present invention provides improved methods for the production of recombinant peptides from bacterial cells. | 2009-10-01 |
20090246832 | PRODUCTION OF POLYSIALIC ACID CONTAINING GLYCOCONJUGATES USING A SELF-PRIMING POLYSIALYLTRANSFERASE - The invention relates to a fusion protein comprising a bifunctional sialytransferase and a poly-sialytransferase and methods to use the fusion proteins for production of poly-sialylated end products, e.g. oligosaccharides and glycoproteins. | 2009-10-01 |
20090246833 | Small interfering RNAS as non-specific drugs - The present invention is directed to a method of modulating (e.g., inducing, inhibiting) activation of a double stranded RNA (dsRNA) signaling pathway, such as the dsRNA signaling pathway that accompanies RNA interference (RNAi) of a target RNA sequence, in a cell, comprising introducing into the cell small interfering RNA (siRNA) that degrades the target RNA sequence, and maintaining the cell under conditions in which RNAi of the target RNA sequence occurs and activation of the dsRNA signaling pathway is modulated in the cell. | 2009-10-01 |
20090246834 | Nano-PCR: methods and devices for nucleic acid amplification and detection - Methods, devices, and compositions are described that provide for amplification of nucleic acid sequences without reliance upon temperature cycling, thus freeing the methods from conventional benchtop thermal cycling devices. Denaturation of double stranded nucleic acids, primer annealing, and precision control over primer extension by polymerase can be accomplished by applying stress to a nucleic acid. These methods can provide one or more benefits over conventional PCR methods including: precision control over the PCR process; generally improved fidelity; improved accuracy over problematic sequences such as GC-rich or tandem repeat regions; greater sequence length; increased reaction yield; reduced experimental time; greater efficiency; lower cost; greater portability; and, robustness to various environmental parameters, such as temperature, pH, and ionic strengths. | 2009-10-01 |
20090246835 | L-AMINO ACID-PRODUCING BACTERIUM AND A METHOD FOR PRODUCING AN L-AMINO ACID - An L-amino acid is produced by culturing a microorganism of the family Enterobacteriaceae which has the ability to produce an L-amino acid and which has been modified so as to increase the expression of the evgA gene, the gadE gene, and/or the ydeO gene. These genes encode a transcription factor involved in the EvgAS two-component system regulon. The culture takes place in a medium, and the L-amino acid is collected from the medium or cells. | 2009-10-01 |
20090246836 | Pgro expression units - The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms. | 2009-10-01 |
20090246837 | Process for The Preparation of Optically Active Chiral Amines - The present invention relates to the production of optically pure secondary amines, which can be used as intermediate products in a synthesis of for instance pharmaceutical products. | 2009-10-01 |
20090246838 | Process For The Production Of Cadaverine - Process for the production of cadaverine by constructing a recombinant microorganism which has a deregulated lysine decarboxylase gene and at least one deregulated gene selected from the group (i) which consists of aspartokinase, aspartatesemialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydrodipicolinate reductase, tetrahydrodipicolinate succinylase, succinyl-amino-ketopimelate transaminase, succinyl-diamino-pimelate desuccinylase, diaminopimelate epimerase, diaminopimelate dehydrogenase, arginyl-tRNA synthetase, diaminopimelate decarboxylase, pyruvate carboxylase, phosphoenolpyruvate carboxylase, glucose-6-phosphate dehydrogenase, transketolase, transaldolase, 6-phosphogluconolactonase, fructose 1,6-biphosphatase, homoserine dehydrogenase, phophoenolpyruvate carboxykinase, succinyl-CoA synthetase, methylmalonyl-CoA mutase, provided that if aspartokinase is deregulated as gene (i) at least a second gene (i) other than aspartokinase has to be deregulated, and cultivating said microorganism. | 2009-10-01 |
20090246839 | Enzymatic modification of triglyceride fats - Process wherein the fatty acid residues on a glyceride moiety are randomised over the terminal and middle positions, wherein the process proceeds to a conversion degree on the terminal positions, Re, ranging from 0.3 to 0.95, and wherein a conversion degree on the middle position, Ra, ranges from 0.06 to 0.75, and wherein Ra is greater than 0.32Re-0.08, the process comprises the exposure of a triglyceride fat to a catalyst comprising a lipase wherein the lipase is a Thermomyces lanuginosa lipase which has an activity of at least 250 IUN corresponding to 22 g/(g*h) at the onset of the process. | 2009-10-01 |
20090246840 | PROCESS FOR PRODUCING ISOMER ENRICHED CONJUGATED LINOLEIC ACID COMPOSITIONS - A process for the preparation of a composition comprising the cis9, trans11 and trans10, cis12 isomers of conjugated linoleic acid (CLA) comprises: providing a mixture comprising cis9, trans11 and trans10, cis12 isomers of conjugated linoleic acid (CLA) in which one of the cis9, trans11 and trans10, cis12 isomers is present in a first weight ratio X of at least 1.3:1 with respect to the other isomer; and subjecting the mixture to crystallisation to form a composition comprising the cis9, trans11 and trans10, cis12 isomers in which one of the cis9, trans11 and trans10, cis12 isomers is present at a second weight ratio Y with respect to the other isomer, wherein Y is greater than X. | 2009-10-01 |
20090246841 | Methods and compositions for production of acetaldehyde - The present disclosure provides methods for producing acetaldehyde from renewable biological resources, for example, from a fermentable substrate, with the advantages of energy efficiency and ease of purification. Particular embodiments, feature the production of acetaldehyde from pyruvate, wherein the pyruvate is generated from various carbon sources (e.g., sugars) by pyruvate-producing microorganisms. The methods comprise culturing a pyruvate-producing microorganism in a culture medium under conditions such that pyruvate is excreted and accumulates extracellularly, resulting in a pyruvate-enriched medium. | 2009-10-01 |