40th week of 2012 patent applcation highlights part 59 |
Patent application number | Title | Published |
20120252595 | WOOD-TYPE GOLF CLUB HEAD WITH ADJUSTABLE SOLE CONTOUR - A wood-type golf club head with an adjustable keel zone member is disclosed herein. The golf club head includes a body and an adjustable keel zone member. The body has a front portion, a crown portion and a sole portion. The body also having a heel end, a toe end and an aft end. The sole portion has only a single keel point. The adjustable keel zone member is disposed within a keel zone of the sole and located preferentially with respect to the center of gravity. The keel zone member is capable of adjusting the face angle of the wood-type golf club head. | 2012-10-04 |
20120252596 | GOLF CLUB WITH BEZELED JEWELRY - A golf club with a rigid shaft band is disclosed herein. More specifically, the present invention discloses a golf club with a rigid shaft band that is placed at a precise location on the shaft itself, utilizing a precise taper within the internal surface of the rigid shaft band to control the location. Even more specifically, the rigid shaft band may be placed at a distance that is greater than about 1 inch and less than about 3 inches away from the butt end of the golf club with a tapered internal surface of greater than about 0.573 degrees and less than about 1.146 degrees. | 2012-10-04 |
20120252597 | GOLF CLUB ASSEMBLY AND GOLF CLUB WITH AERODYNAMIC FEATURES - A golf club head includes a body member having a length dimension, a height dimension, a breadth dimension, a center-of-gravity and a face-squared centerline. The body member includes a channel having an inlet, an outlet and a throughbore extending through the body member from the inlet to the outlet. The inlet is located to a heel-side of the centerline of the body member and the outlet is located to a toe-side of the centerline of the body member. A golf club including the golf club head is also provided. | 2012-10-04 |
20120252598 | CLUB HEADS WITH CONTOURED BACK FACES AND METHODS OF MANUFACTURING THE SAME - Embodiments of club heads with contoured back faces and methods of manufacturing the same are described herein. Other embodiments and related methods are also disclosed herein. | 2012-10-04 |
20120252599 | Golf Clubs and Golf Club Heads - A golf club head enables the initial velocity of a ball to be increased and enables the carry to be lengthened. In some example structures, the golf club includes a face plate formed from metal and club head body (e.g., a crown and sole) formed from fiber reinforced plastic. A weighted body is provided inside the rearmost portion of the golf club head and a low rigidity portion whose width becomes gradually narrower as it approaches the rearmost portion is provided in the crown extending from the vicinity of the face plate to the rearmost portion. | 2012-10-04 |
20120252600 | IRON GOLF CLUB HEAD AND IRON GOLF CLUB - An iron golf club head includes: a head portion; and a badge portion adhered to the head portion. The head portion includes: a face surface; and a back surface located behind the face surface. The badge portion is adhered to at least one of a first largest amplitude region where an amplitude in a fourth-order vibration mode of the back surface is the largest and a second largest amplitude region where an amplitude in a fifth-order vibration mode of the back surface is the largest. As a result, there can be obtained an iron golf club head and an iron golf club, in which by suppressing decrease in resonant time of the hitting sound and reducing the sound pressure of the hitting sound, the hitting sound and the hitting feeling can be improved. | 2012-10-04 |
20120252601 | Golf Club Head or Other Ball Striking Device Having Custom Machinable Portions - A ball striking device, such as a golf club, includes a head with a face having a ball-striking surface configured for striking a ball, a body connected to the face, and at least one weight element connected to the body. The head has a total weight that is higher than a target weight of the head, and the at least one weight element is configured to be at least partially removed by a material removal technique to lower the total weight of the head to approximately equal the target weight. The at least one weight element may be integrally connected to the body, such as being integrally formed with at least a portion of the body. The material removal technique may constitute milling, machining, or other material removal techniques or combination of such techniques. | 2012-10-04 |
20120252602 | WEDGE TYPE GOLF CLUB HEAD - A wedge type golf club head is disclosed herein where the wedge type golf club head has enhanced performance characteristics such as improved backspin, ball speed, and launch angle. More specifically, the present invention relates to a wedge type golf club head having a lower center of gravity, where the center of gravity is located substantially behind the hitting surface and substantially along a neutral axis behind the point of impact. | 2012-10-04 |
20120252603 | THREE-LAYER-CORE GOLF BALL HAVING HIGHLY-NEUTRALIZED POLYMER OUTER CORE LAYER - A golf ball including an inner core layer formed from a thermoset rubber composition and having a first surface hardness; a thermoplastic outer core layer having a second surface hardness, an inner surface hardness, and being formed from a copolymer of ethylene and an α,β-unsaturated carboxylic acid, an organic acid or salt thereof, and sufficient cation source to fully-neutralize the acid groups of the copolymer; an inner cover layer; and an outer cover layer; wherein the first surface hardness is substantially the same as the second surface hardness and the inner surface hardness. | 2012-10-04 |
20120252604 | GOLF BALL - An object of the present invention is to provide a golf ball having an improved controllability and shot feeling while maintaining a flight distance on driver shots. The present invention provides a golf ball having a core, an intermediate layer disposed around the core, and a cover disposed around the intermediate layer, wherein the core has a center and an envelope layer disposed around the center, and has a specific hardness distribution, and the intermediate layer is formed from an intermediate layer composition comprising, as a resin component, (A) a modified polyester elastomer and (B) a binary ionomer resin, and having a flexural modulus ranging from 150 MPa to 450 MPa, a maximum loss factor (tan δ) between −20° C. and 0° C. of 0.08 or less, a repulsive modulus of 55% or more, and a slab hardness ranging from 60 to 90 in JIS-hardness. | 2012-10-04 |
20120252605 | Water Basketball and Volleyball Game Apparatus - A water basketball and volleyball apparatus can be used with a swimming pool, and includes a hoop for water basketball and a net for water volleyball. The apparatus has two pillars, a primary and secondary pillar, positionable directly across the swimming pool. The primary pillar has a base and an upwardly extending vertical post. The vertical post has inner and outer pipes for selectively adjusting the height of the basketball hoop. A horizontal post is coupled ninety degrees with the vertical post. A distal end of the horizontal post has a bracket coupled to a backboard which carries the hoop. The primary pillar has two screws for anchoring one end of the net. The secondary pillar has a base and an upwardly extending vertical post having two screws for anchoring the opposing end of the net. | 2012-10-04 |
20120252606 | Sporting Goal Transport System - A sport goal movement system that includes drive and control systems. The drive system preferably includes a motor that selectively drives one of a wheel or a track. The drive system can be integrated with and/or permanently or removably secured to the sport goal assembly. Operation of the drive system effectuates single user unassisted and possibly remote translation of the sport goal assembly relative to a ground surface. | 2012-10-04 |
20120252607 | Folding Basketball Goal - The invention disclosed is a foldable basketball goal apparatus that is usable as a basketball goal for playing the game of basketball in the active position. When in the folded, home position, the apparatus is usable as a sports table or for other activities requiring a table. The apparatus is made of a base, a frame assembly, and a basketball goal assembly. The basketball goal assembly is rotatable and slidable with respect to the frame assembly. The frame assembly is pivotally attached to the base. In the home position, the frame assembly is lowered to rest on the base and the basketball goal assembly is rotated 180 degrees and retracted beneath the table surface. A frame assembly partial table surface forms a complete table surface when in the home position, mated with base table surface portions. The rim is protected within the base structural frame when in the home position. | 2012-10-04 |
20120252608 | APPARATUS AND METHOD FOR THE GAME OF BASEBALL FOR THE BLIND - An apparatus for the game of baseball for the blind comprises a base for the game of baseball for the blind comprising: sound reproduction means; and a control and operating unit, connected to the sound reproduction means for activating a reproduction of a sound depending on a control signal, the apparatus further comprising a control device, equipped with a control push-button, operatively connected to the control and operating unit for allowing a user to transmit the control signal to the control and operating unit. | 2012-10-04 |
20120252609 | Racquet Weight - A weight for a racquet includes a weight. The weight is joined at least partially to a joining portion of the racquet. A joining mechanism is also included. The joining mechanism is configured to join the weight at least partially to the joining portion of the racquet. | 2012-10-04 |
20120252610 | BALL BAT INCLUDING INTEGRAL BARREL FEATURES FOR REDUCING BBCOR - A ball bat includes a barrel having one or more integral features for selectively stiffening regions of the barrel. The barrel may include an indented region forming a rib projecting inwardly into the barrel. Alternatively, one or more inwardly projecting lips may be formed on adjoining barrel sections that are bonded, welded, or otherwise attached to each other, such that an integral, internal rib is formed in the barrel. The internal rib stiffens the barrel, thus reducing the barrel's BBCOR. One or more integral ribs may be provided at any desired barrel locations for selectively limiting the barrel's performance without appreciably increasing the moment of inertia of the ball bat. In another embodiment, a joint, to which two barrel sections are bonded, welded, or otherwise attached, includes an inwardly projecting member that stiffens the barrel, thus reducing the barrel's BBCOR. | 2012-10-04 |
20120252611 | Projectile Launching Device - A sports and games apparatus consisting of two rods and an aerodynamic projectile with an opening which receives the two rods. The projectile is launched by manipulating the rods in an opposing fashion. The opening of the projectile is of the appropriate size to allow for the rods to slide through, but not large enough that the projectile exhibits unwanted motions that inhibit accuracy during the launching motion. The rods are used to propel the projectile towards a variety of targets which interact with the projectile in various ways. The projectile may comprise a multitude of aerodynamic shapes and a multitude of methods for interacting with targets. | 2012-10-04 |
20120252612 | DEVICE AND METHOD FOR CONTROLLING A BELT-TYPE CONTINUOUSLY VARIABLE TRANSMISSION FOR A VEHICLE - A vehicle belt-type continuously variable transmission expands the operating range in which belt slip control is permitted with maintained estimated accuracy of a belt slip condition, to reduce drive energy consumption owing to a reduction in belt friction. It includes a primary pulley and a secondary pulley around which a belt is wound to control gear ratio by controlling primary and secondary hydraulic pressures, a belt slip control means for controlling secondary hydraulic pressure according to a phase difference between oscillation components due to oscillation included in an actual gear ratio and in an actual secondary hydraulic pressure, and a transmission speed limiting means for determining whether or not to limit vehicle acceleration according to a predetermined acceleration limit permitting condition and limiting a transmission speed to less than a predetermined value when determining to limit the vehicle acceleration. | 2012-10-04 |
20120252613 | TREADLE-DRIVE ELLIPTICAL WHEEL TRANSMISSION WHEEL SERIES WITH PERIODICALLY VARIED SPEED RATIO - The present invention is structured by using one or both of an active wheel and a passive wheel to be constituted by a bimodal elliptical wheel, so that in the reciprocal treadle performed by the human's feet, when the feet input forces at different angles to an active wheel shaft combined on the active wheel through cranks and treadle shafts of the treadles, the active wheel forms different transmission speed ratios relative to the passive wheel according to the treadle angle. | 2012-10-04 |
20120252614 | TREADLE-DRIVE ECCENTRIC WHEEL TRANSMISSION WHEEL SERIES WITH PERIODICALLY VARIED SPEED RATIO - The present invention is structured by using one or both of an active wheel and a passive wheel being composed of an eccentric transmission wheel and being combined with a synchronous transmission belt for forming an eccentric wheel transmission wheel series, so that in the reciprocal treadle performed by the human's feet, when the feet input forces at different angles from the treadle shafts of the treadles to an active wheel shaft combined on the active wheel through cranks, the active wheel forms different transmission speed ratios relative to the passive wheel according to the treadle angle. | 2012-10-04 |
20120252615 | HYDRAULIC TENSIONER - A hydraulic tensioner applies appropriate tension to an endless power transmitting belt. The hydraulic tensioner includes a plunger body, an oil supply path, a check valve, a relief valve, a pressure maintaining valve interposed in a relief path and a pressure accommodating hole. The hydraulic tensioner is configured such that a path that is branched from the oil supply path for operating the pressure maintaining valve is formed independently of a supply path to the check valve. | 2012-10-04 |
20120252616 | AIR BLEEDING VALVE FOR HYDRAULIC TENSIONER OF AN ENGINE AND HYDRAULIC TENSIONER INCORPORATING SAME - An air bleeding valve includes an annular valve element for removing air from oil contained in a hydraulic circuit of a hydraulic tensioner and for suppressing the removal of the oil. An air bleeding valve body is fitted in an air bleeding valve accommodating hole formed in the hydraulic tensioner. A circumferential groove having a rectangular cross section is formed on an outer circumferential surface of the air bleeding valve body. The annular valve element having a rectangular cross section is fitted in the circumferential groove so as to be movable in an axial direction parallel to the axis of the annular valve element, and displaceable in a radial direction toward and away from the axis of the annular valve element. Such air bleeding valve removes air in a hydraulic circuit while suppressing the removal of oil in the hydraulic circuit during starting operation of an engine. | 2012-10-04 |
20120252617 | TRANSPORTING APPARATUS WITH BELT - A transporting apparatus is disclosed. The transporting apparatus comprises a mounting plate; a assistant wheel assembly attached to the mounting plate, the assistant wheel assembly comprising an inner wheel, an outer wheel, and an elastic member; the elastic member is between the inner wheel and the outer wheel; a driving wheel movably attached to the mounting plate; a driving member secured to the driving wheel; and a belt connecting the outer wheel and the driving member; wherein the elastic member is generally deformed at a location where the belt warps on the outer wheel. | 2012-10-04 |
20120252618 | Torque-Application Test Stand for Transmissions - A torque-application test stand in which a belt drive or chain drive having two fixed belt stations and having one belt station which is movable in a linear manner between the two fixed belt stations is provided. A telescopic universal-joint propeller shaft for length compensation is arranged between the belt station which is movable in the linear manner and a bearing support for a test object. The belt station which is movable in the linear manner is moved during testing, thus producing a superimposed rotary motion of the universal-joint propeller shaft connected to the test object. | 2012-10-04 |
20120252619 | TOOTHED BELT - Configuring the inside of a tooth portion | 2012-10-04 |
20120252620 | DRIVE ARRANGEMENT FOR A VEHICLE ACCESSORY - A drive arrangement for auxiliary equipment of an engine includes an epicyclical gear having a sun gear, a ring gear and a planet carrier. A first component is connected to the engine, a second component is connected to a first electric machine, and a third component is connected to the auxiliary equipment. The first component is guided in rotation on the engine block and includes a rigid assembly which supports the other two components. The stator of the first electric machine is fixed on a holder. The holder is guided in rotation directly or indirectly on the first component rigid assembly, and the first component is guided in rotation on the engine block independently from the holder. | 2012-10-04 |
20120252621 | DIFFERENTIAL ASSEMBLY AND DRIVING ASSEMBLY WITH A DIFFERENTIAL ASSEMBLY - A differential assembly is disclosed, and more particularly a differential assembly for a motor vehicle driving axle drivable by an electric motor. The differential assembly comprises a driving gear; a differential drive with an input part and two output parts, wherein the output parts are drivingly connected to the input part and, relative to one another, have a differential effect; a coupling which is arranged effectively between the driving gear and the differential drive, wherein, in a closed condition of the coupling, torque is transmitted from the driving gear to the differential drive and, in an open condition of the coupling, a transmission of torque is interrupted; a controllable actuator for actuating the coupling and a sensor for determining at least three switched positions of the coupling. Furthermore, a driving assembly with such a differential assembly is also disclosed. | 2012-10-04 |
20120252622 | TREADLE-DRIVE ECCENTRIC WHEEL TRANSMISSION WHEEL SERIES WITH PERIODICALLY VARIED SPEED RATIO - The present invention is structured by using one or both of an active wheel and a passive wheel being composed of an eccentric transmission wheel and being combined with a synchronous transmission belt for forming an eccentric wheel transmission wheel series, so that in the reciprocal treadle performed by the human's feet, when the feet input forces at different angles from the treadle shafts of the treadles to an active wheel shaft combined on the active wheel through cranks, the active wheel forms different transmission speed ratios relative to the passive wheel according to the treadle angle. | 2012-10-04 |
20120252623 | POWER TOOL - Embodiments of the present invention may include a power tool having a driving motor, a spindle with a front tool and a continuously variable transmission mechanism. The driving motor is configured to output any number of output rotations. The continuously variable transmission mechanism is configured to shift the number of rotations from the driving motor in any ratio and output the shifted rotation to the spindle. The driving motor changes the number of output rotations. The continuously variable transmission mechanism changes the ratio. Both the driving motor and the continuously variable transmission mechanism serve to alter the rotational speed of the spindle. | 2012-10-04 |
20120252624 | DIFFERENTIAL ASSEMBLY - A differential assembly having a gearset, which has first and second side gears and a plurality of pinion sets, and a case assembly. Each pinion set has a first pinion meshingly engaged to the first side gear, and a second pinion meshingly engaged to both the second side gear and the first pinion gear. The case assembly has a case structure, a case cover and a gearset mount. The case structure defines a cavity into which the gearset mount is received. The gearset mount defines a plurality of first pinion bores into which the first pinions are received, a plurality of second pinion bores into which the second pinions are received and a side gear pocket into which the first side gear is received. The gearset mount is fixedly and non-rotatably coupled to the case cover. The case cover is separately coupled to the case structure. | 2012-10-04 |
20120252625 | LIMITED SLIP DIFFERENTIAL HAVING A DYNAMIC THRUST DEVICE - A limited slip differential comprising an input member and two output members and moreover having, built into a housing, at least one planet gear and at least one sun gear that are arranged so as to enable total or partial securing, rotatably, of two of the three input and/or output members by means of at least one thrust means on a securing means during a decrease in one of the output torques caused by grip loss or shifting into differential velocities. The differential also includes at least one second dynamic thrust means that is antagonistic to the thrust of the first thrust means, the antagonistic second dynamic thrust means being arranged so as to be activated during a shift of the differential into differential velocities. | 2012-10-04 |
20120252626 | NINE SPEED DUAL CLUTCH TRANSMISSION - A transmission is connectable to an input member and includes first and second shaft members, first and second countershaft members, a plurality of co-planar gear sets, a compound planetary gear set, a plurality of torque transmitting elements, and an output member. The torque transmitting devices include a plurality of brakes, synchronizer assemblies, and clutches including a dual clutch assembly. The transmission is operable to provide at least three reverse speed ratios and at least nine forward speed ratios between the input member and the output member. | 2012-10-04 |
20120252627 | PINION SHAFT SUPPORT STRUCTURE FOR PLANETARY GEAR - To allow attachment of pinion shafts in their phased states only in simple steps which do not require a crimping step and a special device. A pinion shaft support structure for a planetary gear includes pinion gears, pinion shafts for pivotally supporting the pinion gears, and a carrier having a plurality of shaft support holes for rotatably supporting the pinion shafts, the pinion shafts being supported by the shaft support holes. The pinion shaft support structure includes stepped portions formed on end surfaces of the pinion shafts and a fall-out prevention washer which is mounted on the carrier to be capable of locking the stepped portions. An outer circumferential rim of the fall-out prevention washer mounted on the carrier faces the stepped portions of the respective pinion shafts inserted into the plurality of respective shaft support holes and is capable of locking the stepped portions, and the pinion shafts are thereby positioned (phased) in their rotational directions. | 2012-10-04 |
20120252628 | VEHICLE SHIFT CONTROL SYSTEM - When a P lock state is set on the basis of a predetermined request signal for setting the P lock state, a P position indicator lamp ( | 2012-10-04 |
20120252629 | METHOD FOR MONITORING THE OPERATION OF A DRIVE TRAIN - A method for monitoring the operation of a drive train of a motor vehicle, the drive train including a drive machine, a clutch and an automated transmission, and the drive train having an emergency program, which enables an emergency operation of the drive train even if important control signals such as engine torque, engine speed, transmission speed are missing, where the emergency operation is initiated as soon as one of the following signals is no longer present: engine torque or a substitute value for the engine torque, torque requested by a driver or a substitute for the torque requested by the driver, engine speed, transmission input speed. | 2012-10-04 |
20120252630 | GEAR RATIO CONTROL DEVICE, METHOD FOR CONTROLLING GEAR RATIO, AND VEHICLE - A gear ratio control device includes a controller configured to control gear ratio in a vehicle. The controller is configured to adjust an eccentricity of first supporting points of the eccentric discs so that, in the event of starting a power source in a state in which the power source is stopped and the vehicle is traveling, the gear ratio at a continuously variable transmission is at a target value, in parallel with performing start control of the power source. | 2012-10-04 |
20120252631 | HYDRAULIC CONTROL DEVICE OF AUTOMATIC TRANSMISSION - A hydraulic control device of an automatic transmission is provided, which includes a hydraulic control circuit with a pressure reducing valve including a first friction element for achieving a first gear position and a second friction element for achieving a second gear position that produces a lower speed than the first gear position. The hydraulic control circuit further includes a switch valve formed with an input port which is inputted with the line pressure in a forward gear position range, and which is switched between a first state where the input port communicates with a first oil path communicating with the first friction element in a failure state of power distribution to the plurality of hydraulic control valves, and a second state where the input port communicates with the second friction element in the same power distribution failure state. The switch valve includes various control ports to control its function. | 2012-10-04 |
20120252632 | METHOD FOR CONTROLLING AN AUTOMATED FRICTION CLUTCH - A method for controlling an automated friction clutch arranged in a drive train between an internal combustion engine and a gearbox, including: operating the friction clutch by a clutch actuator controlled by means of a controller; transmitting actual clutch torque by means of the friction clutch; implementing actual clutch torque that can be transmitted by means of the friction clutch and that can be adapted to the transmission behavior of the friction clutch by means of a control variable of the clutch actuator associated with a target torque of the clutch torque to be transmitted; operating the friction clutch in an engaged state while the target torque is specified; and adapting the target torque depending on clutch torque estimated from the operating data of the engine. The target torque corresponds to an engine torque that is generated by the internal combustion engine and that is applied with a safety margin. | 2012-10-04 |
20120252633 | Personal Exerciser for Head and Neck Muscle Strengthening and Method Therefor - A personal exerciser for head and neck muscle strengthening comprises at least one part, intended to be inserted in a user's mouth during exercising and another part intended to cover the area around the lips, mouth and chin to prevent wrinkle formation and choking during exercising. A multiple layered structure is used in the form of a deformable, pliable composition covered with durable, resilient, elastomeric material. This structure allows fitting the personal exerciser inside the mouth and around the lips, mouth and chin of each unique individual. Isomeric and isotonic exercising of the head and neck muscles are performed simultaneously utilizing the inherent resistance of the elastomeric material. A method of use of the personal exerciser for head and neck muscles is adaptable for use in speech therapy, smoking cessation therapy, obesity treatment and treatment of complications from cosmetic surgeries and procedures. | 2012-10-04 |
20120252634 | TRAMPOLINE WITH COLLAPSIBLE ENCLOSURE ASSEMBLY - An enclosure assembly ( | 2012-10-04 |
20120252635 | MOBILE TREADMILL - A mobile treadmill and a method for powering the mobile treadmill are disclosed. The mobile treadmill includes a trailer, a conveyor, a drive system, and a disconnect. Further, the mobile treadmill is powered by its linear movement on the ground. When the mobile treadmill is moved, wheels on the trailer rotate. The drive system is coupled to one of the wheels and transfers the power from the rotation of the wheel to the conveyor. | 2012-10-04 |
20120252636 | EXERCISE TRAINING APPARATUS - An exercise training apparatus of the present invention includes two bases and an inflatable body. The bases respectively include a filling hole, a lid, a storage space and a water absorber. The filling hole communicates with the storage space. The lid detachably covers the filling hole, and the water absorber is located in the storage space. The inflatable body has a first and a second target portion connecting to each other. The first and the second target portion respectively connect to one of the bases. Thereby, inflatable body is formed as the crotch of a human body for users to kick or attack upwards. The bases can be filled with liquid so as to increase weight to the inflatable body, and the water absorber can hold the liquid to keep the gravity at the bottom of the bases. Consequently, the invention has a well balanced structure. | 2012-10-04 |
20120252637 | Height Adjustable Double End Training Bag - A height adjustable double end training ball apparatus for use in boxing, martial arts and other combat/fighting sports training. The double end training ball having an aperture that extends through the center of the ball and having openings at each end of the aperture on the surface of the ball; a cord having a length suitable to extend from an upper surface to a lower surface, such as a floor and ceiling, in a room where the double end training ball will be used, wherein one end of said cord is connected to the upper surface and the opposite end of the cord is connected to the lower surface; and a pair of restraining elements. The double end training ball is secured on the cord via the application of the restraining elements, such as clamps, at a position above and below the ball. | 2012-10-04 |
20120252638 | Method and Device for Facilitating Use of an Exercise Ball - A method for using an exercise device for facilitating a user to perform a variety of exercises using an exercise ball supported on the device is disclosed. The device comprises a pouch having a mouth end wherein the pouch is configured to form a seat portion to the user. The device further includes a plurality of linking members attached to the mouth end by an attachment means and a plurality of straps. The lower end of the plurality of straps is secured to the linking members and the upper end of the plurality of straps is attached to a securing means. Each of the pair of straps is crisscrossed in preparation for attachment to the exercise ball. The crisscrossed straps are looped around the ball and secured by using the securing means. The crisscross arrangement of the straps securely holds the exercise ball in relation to the seat portion. | 2012-10-04 |
20120252639 | Apparatus and Method for Exercising a User's Muscles - The invention is directed to an apparatus for exercising a user's muscles that includes a frame. A platform is attached to the frame, which defines an area on which a user stands. A weight stack is attached to the frame. A lineal shaft is attached to the frame between the platform and the weight stack. A carriage runs on the lineal shaft and is attached to the weight stack by a cable. An extension arm is pivotally connected to the carriage. A handle is attached to the extension arm. The lineal shaft and platform allow the user to adjust the machine to their body by just standing in the position that fits their body. The lineal shaft, carriage, and pivotal connected extension arm provides a resistance curve that fits the user's strength curve. | 2012-10-04 |
20120252640 | Dynamic weight lifing machine - An exercise system utilizes exercise apparatus having at least two operative positions, a first operative position with a base fixedly contacting a floor, and a second operative position with the base spaced apart from the floor and horizontally moveable over the floor in any desired direction of travel. When a barbell is mounted at rest on the exercise apparatus the apparatus is in the first operative position. When the barbell is disengaged from the at rest position, the exercise apparatus moves to the second operative position. | 2012-10-04 |
20120252641 | Quick Lock Kettlebell Handle - The present invention relates to a new handle for adapting kettlebell weights and for new modes of lifting weights. | 2012-10-04 |
20120252642 | MULTI-FUNCTIONAL LINKED FITNESS EQUIPMENT - A multifunctional linked fitness equipment has an elongated bottom, a seat stand, a front support frame seat pivotally mounted on a front end of the elongated bottom, a rear support frame seat pivotally mounted on a rear end of the seat stand, a link pivotally mounted between the front support frame seat and the rear support frame seat, a front support frame pivotally mounted on the elongated bottom and the front support frame seat, a rear support frame pivotally mounted on the elongated bottom and the rear support frame seat, and at least one resilient member mounted between the rear support frame seat and the elongated bottom. By combining or detaching the front support frame, the rear support frame or the seat stand with or from positioning pins, the fitness equipment can be utilized to selectively exercise the abdominal muscles and the legs based on the users' demand. | 2012-10-04 |
20120252643 | Dynamic resistence training machine - A compact portable exercise machine includes elastic resistance members which are distended or compressed by only a limited amount in order to extend the operational life of the resistance members. Although the elastic resistance members are distended only a relatively short distance during an exercise, the pulled system utilized to distend the elastic members permits a comparatively large range of motion by the individual performing the exercise. The portability of the exercise machine permits it to be readily positioned to perform a relatively large range of exercise. | 2012-10-04 |
20120252644 | OMNI-DIRECTIONAL EXERCISE DEVICE - This disclosure describes, generally, an omni-directional exercise device. The device includes a platform base and resistance bands coupled to the platform base. The device further includes one or more enclosures coupled to the plurality of resistance bands. The one or more enclosures are positioned on top of the platform base at a home position. The one or more enclosures are configured to slide on top of the platform base in a 360-degree range of motion such that the plurality of resistance bands provide resistance at any point on the platform base and are configured to return to the home position. | 2012-10-04 |
20120252645 | EXERCISE DEVICE - Provided is an exercise device including a planar support surface and a rolling joint which is configured to enable a 360° range of motion for the exercise device. In this regard, the user may roll the exercise device along a planar surface in a forward-and-backward motion, a side-to-side motion, or in an arcuate or circular motion. | 2012-10-04 |
20120252646 | Rotating Coupling for Robotic Tool Changer with One-Way Clutch and Dual-Button Handle Mechanism - A manual robotic tool changer provides a compact, lightweight means to manually selectively couple a robotic tool, such as a surgical tool, to a robot arm. The tool changer includes numerous safety features to prevent inadvertent decoupling of the robotic tool. These include a dual-button handle locking mechanism operative to lock the tool changer closed in the fully coupled position, and requiring simultaneous actuation of both of two latch buttons to unlock; a one-way clutch mechanism that prevents rotation of the coupling mechanism towards the decoupled position, unless the handle is actuated to unlock the tool changer; and a spring biasing the tool changer to an at least partially coupled state when no force is applied to the handle, thus requiring a positive force against the spring, moving the handle to a fully open position, to insert or remove a robotic tool. | 2012-10-04 |
20120252647 | Transfer or Feed Drum, With Radial-Arm-Mounted Operating Heads, for Filter or Cigarette Portions - A transfer or feed drum for filter or cigarette portions, the drum having: a central body mounted to rotate about a first axis of rotation; a number of movable assemblies, each of which is fitted to the central body to rotate, with respect to the central body, about a respective second axis of rotation parallel to the first axis of rotation, and supports a pickup or feed head having at least one seat with a U-shaped cross section and for engaging at least one filter or cigarette portion; and an actuating system, which controls the angular position of each movable assembly about the respective second axis of rotation as a function of the angular position of the central body about the first axis of rotation. | 2012-10-04 |
20120252648 | MANUAL DUNNAGE CONVERTING SYSTEM AND METHOD - A motor-free dunnage conversion system for converting a sheet stock material into a relatively less dense dunnage includes a container having a wall with an opening therethrough, a supply of sheet stock material within the container, and a forming member. The forming member has converging sidewalls that define a passage alignable with the opening in the wall. The forming member is a converging chute having a relatively larger inlet spaced from the outlet, which is relatively smaller than the inlet. The forming member functions to crumple the sheet stock material as a packer draws the sheet stock material through the forming member to form a crumpled strip of dunnage. The forming member has a dimension that is larger than a corresponding dimension of the opening to keep the forming member from escaping the container as the packer pulls the stock material through the forming member. | 2012-10-04 |
20120252649 | SHEET PROCESSING APPARATUS THAT FLATTENS FOLDED SPINE OF SHEET BUNDLE AND IMAGE FORMING APPARATUS INCLUDING THE SHEET PROCESSING APPARATUS - A sheet processing apparatus which is capable of stabilizing a stop position of the sheet bundle, to thereby enable creation of a high finish quality product, and is compact in size and can be manufactured at low costs. Conveyance belts convey the sheet bundle to a flattening position. A pressing roller flattens the folded spine of the sheet bundle by pressing the folded spine. Clampers hold the sheet bundle such that the sheet bundle is not moved when flattening is performed. A CPU starts to stop driving of the conveyance belts when the sheet bundle is conveyed to a predetermined location upstream of the flattening position in the conveying direction of the sheet bundle, and stops the sheet bundle at the flattening position by holding the sheet bundle with the clampers before the conveyance of the sheet bundle is stopped. | 2012-10-04 |
20120252650 | CENTRIFUGE - Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants. | 2012-10-04 |
20120252651 | Continuous Centrifuge Feed Pipe Mixing System - A feed pipe mixing system for delivering a homogenous massecuite product to a centrifuge comprising: a vertical feed pipe defining an upper end, and a lower end, the vertical feed pipe comprising: a mixing chamber disposed between the upper and lower ends of the vertical feed pipe and operable to mix a massecuite feed with feed water, surfactants, partially diluted molasses or a combination thereof to produce a massecuite product; a massecuite inlet disposed on the side of the vertical feed pipe above the mixing chamber, wherein the massecuite inlet is configured to deliver a massecuite feed into the vertical feed pipe; a massecuite outlet disposed on the lower end of the vertical feed pipe and configured to discharge the homogenous massecuite product from the feed pipe to a centrifuge; and a feed water pipe configured to deliver feed water, surfactants, partially diluted molasses or a combination thereof to the mixing chamber for mixing with the massecuite feed. | 2012-10-04 |
20120252652 | SILICATE GLASSES HAVING LOW SEED CONCENTRATION - A fusion formable and ion exchangeable silicate glass having a seed concentration of less than about 1 seed/cm | 2012-10-04 |
20120252653 | SETTING AGENT ACCELERATOR FOR REFRACTORY MATERIAL - The present invention relates to a setting agent accelerator for use with an ultra-low cement, low cement and regular castable refractory materials and a method of applying the refractory materials using the setting agent accelerator to form a refractory structure or lining. More particularly, the invention is directed to a setting agent accelerator for use with an ultra-low cement , low cement and regular castable refractory material for preserving or maintaining the safety lining and the working lining of refractory structures or linings from mechanical erosion and/or attack by corrosive materials such as those produced during manufacture of cement, lime, metals or metal alloys including acid and basic slags. The setting agent accelerator has a set accelerating amount of sodium nitrate, sodium nitrite or mixtures thereof, calcium hydroxide and water. | 2012-10-04 |
20120252654 | ZIRCONIA-BASED COMPOSITE CERAMIC SINTERED COMPACT AND METHOD FOR PRODUCING THE SAME - To provide a zirconia-based composite ceramic sintered compact capable of being colored to white appropriate for a dental prosthesis while maintaining its mechanical and physical properties, and also provide a method for producing the same. The method for producing the zirconia-based composite ceramic sintered compact includes semi-sintering a zirconia-alumina composite ceramic containing an alumina particle and a zirconia particle comprising of tetragonal zirconia containing ceria of 8 to 12 mol %, forming the composite ceramic; dipping the formed composite ceramic in a neodymium ion solution or complex solution; drying the dipped composite ceramic; and finally sintering it. | 2012-10-04 |
20120252655 | CERAMIC COMPOSITE MATERIAL CONSISTING OF ALUMINIUM OXIDE AND ZIRCONIUM OXIDE AS MAIN CONSTITUTENTS - A composite material consisting of aluminium oxide as a ceramic matrix and zirconium oxide dispersed therein. The invention also relates to a method for the production thereof and components containing same. | 2012-10-04 |
20120252656 | CERAMIC COMPOSITE MATERIAL CONSISTING OF ALUMINIUM OXIDE AND ZIRCONIUM OXIDE AS THE MAIN CONSTITUENTS, AND A DISPERSOID PHASE - A composite material consisting of aluminium oxide as a ceramic matrix and zirconium oxide dispersed therein. A method for the production thereof, components containing the composite and methods of using the same are also provided. | 2012-10-04 |
20120252657 | DIELECTRIC CERAMIC COMPOSITION AND CERAMIC ELECTRONIC DEVICE - A dielectric ceramic composition comprises barium titanate as a main component, and as subcomponents, 1.00 to 2.50 moles of an oxide of Mg, 0.01 to 0.20 mole of an oxide of Mn and/or Cr, 0.03 to 0.15 mole of an oxide of at least one element selected from a group consisting of V, Mo and W, 0.20 to 1.50 mole of an oxide of R1 where R1 is at least one selected from a group consisting of Y and Ho, 0.20 to 1.50 mole of an oxide of R2 where R2 is at least one selected from a group consisting of Eu, Gd and Tb and 0.30 to 1.50 mole of an oxide of Si and/or B, in terms of each oxide with respect to 100 moles of the barium titanate. | 2012-10-04 |
20120252658 | HONEYCOMB STRUCTURE AND METHOD OF MANUFACTURING HONEYCOMB STRUCTURE - A honeycomb structure includes a honeycomb unit containing zeolite and an inorganic binder and having a plurality of cell walls to define a plurality of cells extending from a first end face to a second end face of the honeycomb unit along a longitudinal direction of the honeycomb unit. The honeycomb unit is manufactured by molding and firing raw material paste containing zeolite particles and the inorganic binder. The zeolite particles have a D50 of approximately 3.6 μm or more. An average pore size of the cell walls is more than or equal to approximately 0.10 μm and less than or equal to approximately 0.50 μm. An average particle size of the cell walls is more than or equal to approximately 3.6 μm and less than or equal to approximately 7.0 μm. | 2012-10-04 |
20120252659 | CATALYST COMPOSITIONS AND APPLICATIONS THEREOF - Structural catalyst bodies are described herein which, in some embodiments, can be used in the treatment of nitrogen oxides present in exhaust or flue gases from stationary or mobile combustion sources. In some embodiments, a structural catalyst body described herein comprises an outer peripheral wall and a plurality of inner partition walls having an average thickness less than about 0.5 mm, the outer peripheral wall and the inner partition walls having dispersed throughout a chemical composition comprising 50-99.9% by weight an inorganic oxide composition, less than 3% by weight an inorganic extrusion aid and at least 0.1% by weight a catalytically active metal functional group comprising vanadium, the structural catalyst body having a crystalline vanadium pentoxide content less than 0.1 weight percent. | 2012-10-04 |
20120252660 | DISPERSED METAL SULFIDE-BASED CATALYSTS - The invention provides a catalyst composition, which includes an emulsion of an aqueous phase in an oil phase, wherein the aqueous phase comprises an aqueous solution containing a group 6 metal and a group 8, 9 or 10 metal. The metals can be provided in two separate emulsions, and these emulsions are well suited for treating hydrocarbon feedstocks. | 2012-10-04 |
20120252661 | HYDROXYALKYLATED POLYALKYLENEPOLYAMINE COMPOSITION, METHOD FOR PRODUCING SAME AND METHOD FOR PRODUCING POLYURETHANE RESIN USING SUCH HYDROXYALKYLATED POLYALKYLENEPOLYAMINE COMPOSITION - Provided is a hydroxyalkylated polyalkylene polyamine composition, and a method for preparing the composition at low cost. Further disclosed is a method for producing a polyurethane resin by using the hydroxyalkylated polyalkylene polyamine composition containing at least two hydroxyalkylated polyalkylene polyamines as defined herein. | 2012-10-04 |
20120252662 | NITROGEN DOPED CARBON NANOTUBES WITH METAL NANOPARTICLES - The invention relates to nitrogen-doped carbon nanotubes (NCNT), the surface of which is charged with metal nanoparticles, and to a method for the production thereof and use thereof as a catalyst. | 2012-10-04 |
20120252663 | SULFUR CONTAINING SILICA PARTICLE - A silica-containing composition is disclosed. The composition comprises a compound having the following formula: (SiO | 2012-10-04 |
20120252664 | Methods For Coating Ceramic Catalyst Supports With Base Coatings And Ceramic Catalyst Supports Having Base Coatings - The disclosure relates to methods for coating ceramic catalyst supports with a base coating, said method comprising, in part, providing an aqueous mixture comprising at least one polyvinyl alcohol homopolymer and at least one blocked isocyanate crosslinker, and to ceramic catalyst supports having a base coating comprising at least one polyvinyl alcohol homopolymer and at least one blocked isocyanate crosslinker. | 2012-10-04 |
20120252665 | MULTIPHASE ALUMINA PARTICLE - A particle having an alpha alumina crystalline phase, a non-alpha alumina crystalline phase and titania is disclosed. The particles are useful as catalyst carriers. A process for making the particles is also disclosed. | 2012-10-04 |
20120252666 | THERMALLY SENSITIVE RECORDING MATERIAL - The present invention provides a heat-sensitive recording material, characterized in that a carrier material carries at least one coating layer in which at least two colour-forming reactants A and B are contained, wherein the layer contains a water-insoluble or sparingly water-soluble iron compound as colour-forming reactant A and a water-insoluble or sparingly water-soluble phenol compound having 2 or more adjacent OH groups as reactant B separated from each other, wherein at least one of the compounds melts at less than 100° C. and this melt reacts with the other colour-forming reactant by colour development in less than 1 second's contact time and at least one of the two colour-forming reactants is present as particles having a size of less than 20 μm. | 2012-10-04 |
20120252667 | INSECTICIDAL 4-AMINO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE - Insecticidal 4-Amino-thieno[2,3-d]-pyrimidine compounds and methods of their use to control pests that damage plants and crops and parasites that harm animals. | 2012-10-04 |
20120252668 | Method for Reducing Nitrous Oxide Emission from Soils - The present invention relates to a method for reducing nitrous oxide emission from soils comprising treating a plant growing on the respective soil and/or the locus where the plant is growing or is intended to grow and/or the seeds from which the plant grows with at least one fungicide (compound A) and at least one ammonium- or urea-containing fertilizer (compound B) wherein the application of at least one compound (A) and at least one compound (B) is carried out with a time lag of at least 1 day. | 2012-10-04 |
20120252669 | PENOXSULAM AS AN HERBICIDE IN ALFALFA - This invention concerns the use of penoxsulam as an herbicide in alfalfa. | 2012-10-04 |
20120252670 | PYRIDINECARBOXAMIDES, USEFUL-PLANT-PROTECTING COMPOSITION COMPRISING THEM AND PROCESSES FOR THEIR PREPARATION AND THEIR USE - Compounds of the formula (I), or salts thereof, | 2012-10-04 |
20120252671 | Herbicide method and apparatus - Apparatus and method for boring into the earth near a Kudzu vine root system to apply herbicidal helium gas to the roots and eradicate the Kudzu vine. The technique uses a perforated tube with a drill bit that protrudes from one end of the tube to bore into the earth near the vine roots. Boring is stopped when all of the tube perforations are below the earth's surface. About 0.5 cubic meters of helium gas are applied to flow through the tube enabling the helium gas to flow out through the tube perforations and attack the Kudzu vine through the vine's root system. | 2012-10-04 |
20120252672 | Competitive and Effective Bacterial Strains - According to the present invention new isolates of bacterial strains have been shown to possess unique properties. These bacterial strains are plant growth-promoting rhizobacterium (PGPR), posses an enhanced competitive advantage at colonizing leguminous plants, and enhance the overall performance of leguminous plant growth. Further still, the present invention discloses a novel method for screening and selecting bacterial strains having the aforementioned beneficial characteristics. | 2012-10-04 |
20120252673 | COMPOSITION AND METHOD FOR STRESS MITIGATION IN PLANTS - A composition and method to mitigate plant autophagy and/or apoptosis of newly developing cells in plants grown under environmentally stressful growing conditions. Exogenous application of a cytokinin, preferably kinetin, to the foliage of plants has been discovered to overcome, or at least mitigate, autophagy when applied during or just prior to flowering. Several provided examples show that, in laboratory and field experiments, exogenous foliar application of cytokinin to the leaves and flowers of plants lessened cytokinin deficiencies in plant tissues grown in high temperatures, thereby mitigating autophagy and apoptosis and greatly enhancing seed/crop production. The application of low concentrations of potassium together with the cytokinin appears to provide a synergistic effect by amplifying the effect of the cytokinin to lessen autophagy and increase crop productivity. | 2012-10-04 |
20120252674 | MIXTURE AND METHOD FOR CONTROLLING UNDESIRED VEGETATION - A herbicide mixture comprising nicosulfuron, metsulfuron-methyl and glyphosate is disclosed. A method for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with a herbicidally effective amount of the herbicide mixture is also disclosed. | 2012-10-04 |
20120252675 | HERBICIDE CONTAINING GLYPHOSATE AND A SURFACTANT CONSISTING ESSENTIALLY OF A POLYALKOXYLATED ALKYLAMINE WHEREIN THE ALKYL GROUP IS BRANCHED - The present invention relates to glyphosate formulations (herbicides) containing glyphosate, and a surfactant consisting essentially of a branched alkylamine where the nitrogen atom in the alkylamine is connected to a branched alkyl group and one, two or three chains of alkylene oxide units(e.g., ethylene oxide units and/or propylene oxide units, including copolymers of ethylene oxide and propylene oxide units). | 2012-10-04 |
20120252676 | Extremely Low Resistance Compositions and Methods for Creating Same - The invention pertains to creating new extremely low resistance (“ELR”) materials, which may include high temperature superconducting (“HTS”) materials. In some implementations of the invention, an ELR material may be modified by depositing a layer of modifying material unto the ELR material to form a modified ELR material. The modified ELR material has improved operational characteristics over the ELR material alone. Such operational characteristics may include operating at increased temperatures or carrying additional electrical charge or other operational characteristics. In some implementations of the invention, the ELR material is a cuprate-perovskite, such as, but not limited to BSSCO. In some implementations of the invention, the modifying material is a conductive material that bonds easily to oxygen, such as, but not limited to, chromium. | 2012-10-04 |
20120252677 | SUPERCONDUCTIVE CABLE - A superconductive electric cable is provided in which a cable core is arranged in a cryostat, where the cable core is composed of three phase conductors arranged concentrically around an inner cooling duct, with an electric insulation arranged between the phase conductors, and where the cryostat is surrounded by an electric insulation, which is surrounded by a neutral conductor of normally conductive materials. In this cable, a neutral conductor or a screening is arranged only outside of the cryostat, and is formed by normally conductive material which surrounds the cryostat as a common neutral conductor, where an insulating material is arranged between this neutral conductor and the cryostat. | 2012-10-04 |
20120252678 | LOW-NOISE COOLING APPARATUS - A low-noise cooling apparatus is provided. The cooling apparatus includes an outer container and an inner container. A thermal insulation layer in a vacuum state is disposed between the outer container and the inner container. The inner container includes a Dewar containing a liquid refrigerant, a prepolarization coil arranged inside the inner container and immersed in the liquid refrigerant, a pick-up coil immersed in the liquid refrigerant, and a superconducting quantum interference device (SQUID) electrically connected to the pick-up coil and immersed in the liquid refrigerant. The prepolarization coil is made of a superconductor. | 2012-10-04 |
20120252679 | FLUX PUMP - The invention provides a flux pump that includes a plurality of superconducting materials arranged to form at least one superconducting loop, at least one of the components being made of a superconductor that includes particles made of a superconductive material and a conductive material selected to be driven to a superconductive state when in proximity to the superconductive material, an unbroken section of the conductive material being located sufficiently close to a plurality of the particles to be driven to a superconductive state by the superconductive material. | 2012-10-04 |
20120252680 | HIGH-TEMPERATURE SUPERCONDUCTING TAPE - Disclosed herein is a high-temperature superconducting tape, including: a substrate; a buffer layer formed on the substrate; and a high-temperature superconducting layer formed on the buffer layer, wherein the substrate is made of SUS310s or stainless steel containing 0.01-1% of silicon (Si) and 1-5% of molybdenum (Mo) and has an average metal crystal grain size of 12 μm or less, and the high-temperature superconducting layer is made of a ReBCO (ReBa | 2012-10-04 |
20120252681 | EVOLUTION OF WHOLE CELLS AND ORGANISMS BY RECURSIVE SEQUENCE RECOMBINATION - The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites. | 2012-10-04 |
20120252682 | METHODS AND SYSTEMS FOR SEQUENCING NUCLEIC ACIDS - The present invention provides methods and systems for sequencing long nucleic acid fragments. | 2012-10-04 |
20120252683 | Binding Affinity Scoring Function Penalizing Compounds Which Make Unfavorable Hydrophobic Contacts With Localized Water Molecules In The Receptor Active Site - A method of scoring binding affinity of a proposed ligand molecule for a receptor molecule using a computer and computer data bases, which accounts for the increase in energy required where docking disrupts water molecules that are localized at ligand hydration sites. The method uses computer-stored data representing a predicted ligand-receptor structure (preferably one that is validated). The computerized scoring analysis includes determining whether the receptor includes one or more hydration sites occupied by localized water, and, if so, assessing a penalty if docking the ligand into the receptor results in unfavorable interaction of the ligand with a localized water molecule remaining at the receptor hydration site (i.e. after docking). | 2012-10-04 |
20120252684 | METHODS OF POPULATING DATA STRUCTURES FOR USE IN EVOLUTIONARY SIMULATIONS - In particular, this invention provides novel methods of populating data structures for use in evolutionary modeling. In particular, this invention provides methods of populating a data structure with a plurality of character strings. The methods involve encoding two or more biological molecules into character strings to provide a collection of two or more different initial character strings; selecting at least two substrings from the pool of character strings; concatenating the substrings to form one or more product strings about the same length as one or more of the initial character strings; adding the product strings to a collection of strings; and optionally repeating this process using one or more of the product strings as an initial string in the collection of initial character strings. | 2012-10-04 |
20120252685 | SEQUENTIAL ANALYSIS OF BIOLOGICAL SAMPLES - Methods for probing multiple targets in a biological sample are provided. The methods include the steps of providing a sample containing multiple targets, binding at least one probe having a binder coupled to an enzyme to one or more target present in the sample, and reacting the bound probe with an enzyme substrate coupled to a fluorescent signal generator. The methods include the steps of observing a signal from the fluorescent signal generator and applying to the sample a solution containing an oxidizing agent that substantially inactivates both the fluorescent signal generator and the enzyme. The methods further include the steps of binding at least one probe having a binder coupled to an enzyme to one or more target present in the sample of step, reacting the bound probe with an enzyme substrate coupled to a fluorescent signal generator; and observing a signal from the fluorescent signal generator. The methods disclosed herein also provide for multiple iterations of binding, observing, and oxidizing for deriving information about multiple targets in a single sample. An associated kit is also provided. | 2012-10-04 |
20120252686 | METHODS FOR MAINTAINING THE INTEGRITY AND IDENTIFICATION OF A NUCLEIC ACID TEMPLATE IN A MULTIPLEX SEQUENCING REACTION - The invention generally relates to methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction. In certain embodiments, methods of the invention involve obtaining a solution including a template nucleic acid, introducing an identifier nucleic acid to the solution, incorporating the same barcode sequence into the template and the identifier nucleic acids, and sequencing the template and the identifier nucleic acids. | 2012-10-04 |
20120252687 | Scoring Function Penalizing Compounds Which Desolvate Charged Protein Side Chains Structure - A method of scoring binding affinity of a proposed ligand molecule for a receptor molecule using a computer and computer data bases, which accounts for the increase in energy required where docking disrupts water molecules that are localized or localized. The method uses computer-stored data representing a predicted ligand-receptor structure (preferably one that is validated) as well as computer-stored data representing a library of compounds to be tested. Data representing members of the compound library is analyzed by computerized operations which determine whether the receptor in the predicted ligand-receptor structure includes a) determining whether the receptor in the predicted ligand-receptor structure includes solvating water molecule(s) whose desolvation into the surrounding environment requires substantial energy, b) determining whether a docking configuration for a member of the compound library with the receptor requires desolvation of one or more of the desolvating water molecule(s), and, if so, assigning a desolvation penalty to the member of the compound library. | 2012-10-04 |
20120252688 | NOVEL BIOMARKERS OF DISEASE HISTOPATHOLOGY - Use of FGF-2 and Anosmin-1 proteins to predict the histopathology of the lesions of a subject with a demyelinating disease of the central nervous system (CNS) by detecting the amount of such proteins in a sample of isolated biological fluid. Furthermore, the present invention relates to a method for the understanding of the histopathological features of the lesions of a subject with a CNS demyelinating disease a kit to carry out this method. Preferably, the CNS demyelinating disease is multiple sclerosis, and the biological fluid is cerebrospinal fluid (CSF). | 2012-10-04 |
20120252689 | GENE EXPRESSION SIGNATURE FOR WNT/B-CATENIN SIGNALING PATHWAY AND USE THEREOF - The present invention relates to a novel set of 16 biomarkers, microarrays that provide for the detection thereof, an expression signature comprising 16 genes or a subset thereof, and the use thereof in determining the regulation status of Wnt/β-catenin signaling pathway. The regulation status of Wnt/β-catenin signaling pathway may be assayed based on the level of expression of one or more of these genes. The expression of these biomarkers may be used to evaluate Wnt/β-catenin pathway deregulation status; classify a cell sample as having a deregulated or regulated Wnt/β-catenin signaling pathway; determine whether an agent modulates the Wnt/β-catenin signaling pathway; predict response of a subject to an agent that modulates the Wnt/β-catenin signaling pathway; assign treatment to a subject; or evaluate the pharmacodynamic effects of therapies designed to regulate Wnt/β-catenin pathway signaling. | 2012-10-04 |
20120252690 | METHOD FOR DETECTING BALANCED CHROMOSOMAL ABERRATIONS IN A GENOME - The present disclosure provides methods and systems for the capture and enrichment of target nucleic acids and analysis of the enriched target nucleic acids for detecting balanced chromosomal aberrations including translocations and inversions. The present disclosure provides for the enrichment of targeted sequences in a format whereby one fusion partner gene on a capturing platform is represented to allow subsequent sequencing of chimeric nucleic acids (i.e., nucleic acid strands that carry information on different DNA regions of a genome). Such a design enables identification of novel fusion partner genes occurring as a result of a chromosomal translocation or inversion. | 2012-10-04 |
20120252691 | MODIFIED NUCLEOTIDES METHODS AND KITS - Modified nucleotides, and methods to modify nucleotides with a moiety or label, such as biotin, that permits their detection and results in a modified nucleotide, and methods of use of the modified nucleotide in quantitative and qualitative assays. | 2012-10-04 |
20120252692 | METHODS AND COMPOSITIONS FOR DETECTION OF NUCLEIC ACIDS BASED ON STABILIZED OLIGONUCLEOTIDE PROBE COMPLEXES - Provided are nucleic acid detection methods wherein targeted primer extension or products or amplification products incorporate a probe-anchoring modification introduced using a primer incorporating a probe-anchoring primer modification, wherein oligonucleotide detection probes incorporate a probe-anchoring probe modification, the primers and probes designed to place the binding site of the oligonucleotide probe proximate to the probe-anchoring primer modification in the detected target sequence. The probe-anchoring modifications of the probe and the primer-extension product form a stabilized complex comprising a detectible duplex of the probe with the detected target sequence. In certain aspects, the probe-anchoring modified primer also incorporates a probe-directing sequence. The methods allow use of exceptionally short oligonucleotide probes (e.g., 10-mer and shorter) enabling establishment of a complete probe inventory or universal library containing a probe complementary to any target nucleic acid sequence. Real-time and post-amplification detection methods are provided, along with detection kits. | 2012-10-04 |
20120252693 | METHODS OF USING SMALL RNA FROM BODILY FLUIDS FOR DIAGNOSIS AND MONITORING OF NEURODEGENERATIVE DISEASES - Described are methods for detection of neuronal pathologies using quantitative analysis in bodily fluids of synapse and/or neurite small RNAs and application of these methods to early diagnosis and monitoring of neurodegenerative diseases and other neurological disorders. | 2012-10-04 |
20120252694 | MARKERS, METHODS, BIOCHIPS AND KITS FOR MILK QUALITY DETECTION - This invention provides markers, methods, biochips and kits for milk quality detection. The present invention particularly provides a method for milk quality detection by means of detecting the particular microRNAs in milk, so as to establish the standard of raw milk content. | 2012-10-04 |