40th week of 2017 patent applcation highlights part 32 |
Patent application number | Title | Published |
20170283719 | PROCESS FOR PRODUCING NAPHTHENIC BRIGHT STOCKS - A process for producing naphthenic bright stocks from low quality naphthenic crude feedstocks. The naphthenic bright stocks produced by the process have improved low temperature properties at high yields based on feedstock. | 2017-10-05 |
20170283720 | PRESSURISING OF BULK MATERIAL IN LOCK HOPPERS - A process for pressurizing bulk material in a hopper; wherein the hopper is configured as a lock hopper ( | 2017-10-05 |
20170283721 | CATALYTIC MEMBRANE SYSTEM FOR CONVERTING BIOMASS TO HYDROGEN - A two-reactor catalytic system including a catalytic membrane gasification reactor and a catalytic membrane water gas shift reactor. The catalytic system, for converting biomass to hydrogen gas, features a novel gasification reactor containing both hollow fiber membranes that selectively allow O | 2017-10-05 |
20170283722 | Sorbent Design for Improved Glycerol Adsorption - Mesoporous organosilica sorbents are effective to remove contaminants (such as glycerol or detergent) from biodiesel. Contacting biodiesel with various a mesoporous organosilica sorbents comprising phenyl and sulfonate moieties resulted in the contaminants being absorbed by the sorbent and thus removed from the biodiesel. | 2017-10-05 |
20170283723 | USE OF HETEROGENEOUS ACID CATALYSTS BASED ON MIXED METAL SALTS TO PRODUCE BIODIESEL - The present invention relates to the production of biodiesel and alkyl esters by the transesterification of triglyceride esters, with alcohols in heterogeneous phase in the presence of heterogeneous catalysts, with yields higher than 80%, at a temperature from 0 to 300° C., residence time from 20 minutes to 20 h, space velocity of 0.1 to 10 h | 2017-10-05 |
20170283724 | Industrial Production Plant Having Minimal Emission of Greenhouse Gases, in Particular Emission of Carbon Dioxide, and Method for the Operation Thereof - The invention relates to an industrial production plant ( | 2017-10-05 |
20170283725 | APPARATUS AND SYSTEM FOR PRODUCING SOLID FUEL FROM BIOMASS - The invention relates to a material and/or solid fuel which is produced from biomass. The material and/or fuel can be produced according to an apparatus and system for producing a fuel from a solid-liquid mixture of water and feed material with a carbon containing component, wherein the biomass forming the solid-liquid mixture is treated at a temperature of 160-300° C. at a pressure of at least 5 bar for a treatment duration of at least 2 hours and water formed by the chemical reaction is withdrawn from the reactor by a solid-liquid separation filtration device to increase a carbon fraction of the fuel. | 2017-10-05 |
20170283726 | SYSTEMS AND METHODS FOR PRODUCING ENGINEERED FUEL FEED STOCKS FROM WASTE MATERIAL - Systems and methods for producing engineered fuels from solid waste material are described herein. In some embodiments, a method includes receiving a waste stream at a multi-material processing platform and separating the waste stream to remove non-processable waste and marketable recyclables. The method further includes conveying processable materials to a material classification system and incorporating additives to produce an engineered fuel from the constituents of the waste stream. | 2017-10-05 |
20170283727 | Mixed Liquid and Solid Fuel Composition - A fuel composition that provides a renewable biofuel energy source for reducing dependence on fossil fuels and improving air quality by reducing the amount of carbon monoxide released into the air during combustion. The fuel composition includes an energy crop comprising: a solid granular component being suspended in a liquid non-petroleum plant based fuel. The liquid fuel containing the granular component is efficacious in releasing copious quantities of vapor for burning. The vapor provides a more complete and efficient burn. The fuel composition further comprises an oxidizing agent for removing a plurality of electrons from the granular component during combustion, and/or an additive that imparts a change in the physical properties of the fuel composition. | 2017-10-05 |
20170283728 | AVIATION FUEL ADDITIVE SCAVENGER - Aviation fuel formulations receive many benefits when a manganese-containing additive is incorporated in that composition. However, to the extent that the use of a manganese-containing compound may result in the formation of engine deposits during combustion, it is beneficial to further provide a scavenger compound to the fuel composition. This scavenger compound may include a phosphorus-containing compound, an organobromide compounds, and/or a tricarbonyl compound. | 2017-10-05 |
20170283729 | BASE STOCKS AND LUBRICANT COMPOSITIONS CONTAINING SAME - A base stock having at least 90 wt. % saturates, an amount and distribution of aromatics, as determined by ultra violet (UV) spectroscopy, including an absorptivity between 280 and 320 nm of less than 0.015 l/gm-cm, a viscosity index (VI) from 80 to 120, and having a cycloparaffin performance ratio greater than 1.05 and a kinematic viscosity at 100° C. between 4 and 6 cSt. A base stock having at least 90 wt. % saturates, an amount and distribution of aromatics, as determined by UV spectroscopy, including an absorptivity between 280 and 320 nm of less than 0.020 l/gm-cm, a viscosity index (VI) from 80 to 120, and having a cycloparaffin performance ratio greater than 1.05 and a kinematic viscosity at 100° C. between 10 and 14 cSt. A lubricating oil having the base stock as a major component, and one or more additives as a minor component. Methods for improving oxidation performance and low temperature performance of formulated lubricant compositions through the compositionally advantaged base stock. | 2017-10-05 |
20170283730 | PRESSURE MEDIUM OIL AND METHOD FOR USING SAID PRESSURE MEDIUM OIL - Provided are a pressure medium oil, containing a Group-14 element-containing organic compound selected from an organic germanium compound, an organic tin compound, and an organic lead compound, and a method for using a pressure medium oil, which includes applying a pressure to a substance via the pressure medium oil. The pressure medium oil does not solidify even under an ultrahigh pressure of more than 3.7 GPa at room temperature (25° C.) and has a low pour point, and hardly dissolves a conductive paste. | 2017-10-05 |
20170283731 | LUBRICANT COMPOSITIONS - A method for improving corrosion protection and friction coefficient in an engine or other mechanical component lubricated with a lubricating oil by using as the lubricating oil a formulated oil. The formulated oil has a composition comprising a lubricating oil base stock as a major component, and a mixture of (i) at least one organic molybdenum compound, and (ii) at least one borated ester, as a minor component. Corrosion protection and friction coefficient are improved as compared to corrosion protection and friction coefficient achieved using a lubricating oil containing a minor component other than the mixture of (i) at least one organic molybdenum compound, and (ii) at least one borated ester. | 2017-10-05 |
20170283732 | MULTIPLE FUNCTION DISPERSANT VISCOSITY INDEX IMPROVER - The present invention provides a multiple function dispersant viscosity index improver, a method of making the multiple function dispersant viscosity index improver, and a lubricating oil comprising the multiple function dispersant viscosity index improver. The multiple function dispersant viscosity index improver comprises two different functional groups, each directly grafted to a polymer backbone having graftable sites. The first functional group comprises the reaction product of an acylating agent and a first amine, the first amine comprising an aromatic primary amine, and the second functional group comprises the reaction product of an acylating agent and a second amine, the second amine comprising an aliphatic primary amine. The first functional group provides the dispersant viscosity index improver with soot handling performance attributes and the second functional group provides the dispersant viscosity index improver with sludge and varnish control performance attributes. | 2017-10-05 |
20170283733 | DISPERSANT VISCOSITY MODIFIERS WITH SULFONATE FUNCTIONALITY - A lubricating composition includes an oil of lubricating viscosity and an oil-soluble dispersant viscosity modifier, which includes an olefin-based polymer backbone and at least one pendent functional group. Each of the at least one pendent functional group is independently attached to the olefin-based polymer backbone by a linking group. The at least one pendent functional group includes a sulfonate moiety. | 2017-10-05 |
20170283734 | Method for Producing Base Lubricating Oil from Waste Oil - A method for recovering base oil from waste lubricating oil by separating base oil range constituents from a waste lubricating oil mixture, thereafter separating higher quality base oil constituents and lower quality base oil constituents from the base oil recovered from the waste lubricating oil mixture and thereafter treating the lower quality base oil constituents to produce marketable base oil. The total base oil produced from a waste lubricating oil mixture by this process is greater than the quantity producible by previous processes using only base oil separation from the waste lubricating oil mixture or processes which use only treatment of the base oil recovered from the waste lubricating oil mixture to produce the product base oil. | 2017-10-05 |
20170283735 | CONTROLLED RELEASE DUAL WALLED MICROCAPSULES - A method of forming dual melamine/acrylic walled microcapsules having improved physical properties and release control as well as the microcapsules formed by the process wherein the capsule wall is formed by the use of select (meth)acrylate monomers and/or oligomers and/or select self-condensing melamine resins. | 2017-10-05 |
20170283736 | CONTROLLED RELEASE DUAL WALLED MICROCAPSULES - A method of forming dual melamine/acrylic walled microcapsules having improved physical properties and release control as well as the microcapsules formed by the process wherein the capsule wall is formed by the use of select (meth)acrylate monomers and/or oligomers and/or select self-condensing melamine resins. | 2017-10-05 |
20170283737 | PRO-FRAGRANCE COMPOUNDS - A compound is provided of Formula (I) | 2017-10-05 |
20170283738 | PROCESS FOR RECOVERING CRUDE TALL OIL - A process and apparatus for recovering crude tall oil are disclosed. Acidulation of a crude tall oil soap stream generates a spent acid stream that comprises lignin and entrained crude tall oil. By subjecting the spent acid stream to dissolved gas flotation, a lignin phase comprising entrained crude tall oil can be recovered and causticized, resulting in recovery of most of the crude tall oil that was present in the spent acid stream. A clarified spent acid stream is also generated, which can be treated with caustic and utilized for a soap washing process that integrates easily into the overall CTO recovery process. The apparatus comprises a crude tall oil acidulation unit, a dissolved gas flotation unit, a causticizing unit, and a soap separation unit. The inventive process marries dissolved gas flotation, a well-known water treatment process, with causticization of a recovered lignin phase, a step known from batch acidulation, to improve overall tall oil recovery from a continuous process. | 2017-10-05 |
20170283739 | Composition - The invention provides a composition comprising a glyceride composition comprising at least about 15% by weight of a glyceride comprising a palmitoyl group at the 2-position, wherein at least 30% by weight of the total palmitic acid content of the composition is present at the 2-position in a glyceride, wherein the composition comprises one or more tocopherols and ascorbyl palmitate in a total amount of up to about 1% by weight, and wherein the composition does not comprise added lecithin. | 2017-10-05 |
20170283740 | FLUORINATED SURFACTANT CONTAINING COMPOSITIONS - A composition includes a fluorinated or perfluorinated organic solvent, and a fluorinated surfactant of the general formula (1): [Formula should be inserted here] Rf is a perfluoroalkyl group having 1-6 carbon atoms. Each occurrence of R | 2017-10-05 |
20170283741 | Aqueous Surfactant Compositions - Aqueous surfactant compositions containing
| 2017-10-05 |
20170283742 | BRANCHED BIODEGRADABLE LOW FOAM NONIONIC SURFACTANTS - A surfactant of structure (I) is useful as a biodegradable low foaming surfactant: where m is a value in a range of 3 to 10, n is a value in a range of 5 to 20 and z is a value in a range of 10 to 25. | 2017-10-05 |
20170283743 | MULTI-LAYER SELF-ADHESIVE GEL AND APPLICATOR - Provided is a multi-layer self-adhesive gel suitable for use in cleaning, disinfecting, deodorizing, and/or scenting of toilets, sinks, wash-bowls, bathtubs, showers, and for delivery of shower gel or shampoo in the shower, bathtub or wash-bowl. The multi-layer self-adhesive gel has at least two different self-adhesive gel layers. One gel layer (A) includes at least one solvent (a1), at least one adhesion promoter (b1) which is different from (a1), and at least one surfactant (c1) which is different from (a1) and (b1). Another gel layer (B) includes at least one solvent (a2), at least one adhesion promoter (b2) which is different from (a2). When the multi-layer self-adhesive gel is applied onto a flat surface of a substrate, (A) and (B) together have a continuous, essentially even surface, remote from the surface of the substrate. Also provided are an applicator containing the multi-layer self-adhesive gel and methods of filling the applicator. | 2017-10-05 |
20170283744 | PEARLY LIQUID DETERGENT COMPOSITION - The present invention relates to a pearly liquid detergent composition comprising a thickener, a pearlescent agent and perfume capsules. The present invention further relates to a method for cleaning textiles using such a pearly liquid detergent composition. | 2017-10-05 |
20170283745 | DETERGENT COMPOSITION - A detergent composition comprising an enzyme and a bleaching compound and comprising two or more distinct regions, wherein the enzyme is located in a first distinct region and the bleaching compound is located in a second distinct region and further wherein a builder comprising an amino acid based compound and/or succinate based compound is located in the first distinct region. The compositions exhibit improved stability of the enzyme. | 2017-10-05 |
20170283746 | BIS-AZO COLORANTS FOR USE AS BLUING AGENTS - This invention relates to bis-azo colorants for use as bluing agents, laundry care compositions comprising bis-azo colorants that may serve as bluing agents, processes for making such bluing agents and laundry care compositions and methods of using the same. The bluing agents are generally comprised of at least two components: at least one chromophore component and at least one polymeric component. These bluing agents are advantageous in providing a whitening effect to fabrics, while not building up over time and causing undesirable blue discoloration to the treated fabrics. | 2017-10-05 |
20170283747 | LAUNDRY SCENT ADDITIVE - A laundry scent additive having polyethylene glycol and perfume. The laundry scent additive enables consumers to control the amount of scent imparted to their laundry. | 2017-10-05 |
20170283748 | ENCAPSULATED CLEANING COMPOSITION - An encapsulated cleaning composition includes a core cleaning composition and a water-soluble film disposed about the core cleaning composition. The core cleaning composition itself includes an ionic liquid, water present in an amount of from 10 to 50 parts by weight per 100 parts by weight of the core cleaning composition, and at least one of a chelant, an enzyme, and a surfactant. The water-soluble film has a disintegration time of less than 90 seconds as determined at 40° C. using distilled water according to MSTM 205, when disposed about the core cleaning composition. The water-soluble film also remains stable for 6 months at 25° C., when disposed about the core cleaning composition. | 2017-10-05 |
20170283749 | WATER SOLUBLE POUCH - A water soluble pouch containing a substrate treatment agent, the water soluble pouch having printed characters, and a process for making the same. | 2017-10-05 |
20170283750 | DRYER-ACTIVATED FABRIC CONDITIONING PRODUCTS HAVING FRANGIBLE BOUNDARIES AND METHODS - A dryer-activated product having a plurality of discrete dryer sheets having a non-woven fibrous substrate, each dryer sheet having at least a first portion, a second portion, and a frangible boundary between the first portion and the second portion, and each of the first portion and the second portion having at least about 0.35 grams of a fabric conditioning active composition. | 2017-10-05 |
20170283751 | APPARATUS FOR PRODUCING WORT - An apparatus for producing a wort includes an outer cylindrical container a lower plate received therein; an inner cylindrical container received in the outer cylindrical container such that a wort circulation space is defined the outer cylindrical container and the inner cylindrical container, wherein a malt screener is received in the inner container above the bottom of the inner cylindrical container to be spaced from the bottom of the inner cylindrical container, wherein the side wall of the inner cylindrical container has a plurality of side holes defined therein, and a wort space is defined between the lower plate and the malt screener in the inner cylindrical container; a wort circulator fluid-communicating with the wort circulation space and the wort space to enable circulation of the wort between the wort circulation space and the wort space; and a heater disposed in the wort circulation space to heat the wort therein. | 2017-10-05 |
20170283752 | WOOD INFUSED LIQUID CONSUMABLES - A method is provided for producing a wood infused liquid consumable. The liquid consumable is contained within a container ( | 2017-10-05 |
20170283753 | Unknown - A wooden container provided for the maturation of a wine or a spirit, comprising wood pieces ( | 2017-10-05 |
20170283754 | EMBRYO ASSESSMENT - A method of ranking embryos to indicate their development potential. The method comprises: obtaining values for a plurality of characteristics relating to the morphological development of the embryos during an observation period; determining for respective ones of the embryos whether or not the embryo has undergone a direct cleavage event, and ranking the embryos determined to have undergone a direct cleavage event with a ranking that indicates a lower development potential than for the embryos not determined to have undergone a direct cleavage event; and for the embryos not determined to have undergone a direct cleavage event, determining whether or not a duration of a predefined developmental stage for the embryo exceeds a predefined threshold duration, and ranking embryos for which the duration of the predefined developmental stage is determined to exceed the predefined threshold duration with a ranking that indicates a lower development potential than for the embryos for which the duration of the predefined developmental stage is not determined to exceed the predefined threshold duration; and for the embryos for which the duration of the predefined developmental stage is not determined to exceed the predefined threshold duration, determining whether or not the relative durations of two predefined developmental stages for the embryo is outside a predefined range, and ranking embryos for which the relative durations of two predefined developmental stages for the embryo is outside a predefined range with a ranking that indicates a lower development potential than for the embryos for which the relative durations of two predefined developmental stages for the embryo is not outside the predefined range. | 2017-10-05 |
20170283755 | ELEMENT FOR INJECTING LIGHT HAVING AN ENERGY DISTRIBUTION - The invention relates to a light injector element ( | 2017-10-05 |
20170283756 | MULTI-CHAMBERS BIOREACTOR, METHODS AND USES - The present disclosure relates to a multi-chamber bioreactor, preferably in a polymeric material with a 3D structure, adapted for cell-mono and co-culture, with at least two entries and outputs of culture medium adaptable to be used as a static culture system and to incorporate a dynamic platform creating a bioreactor. The disclosure also relates to a technique based on a bioreactor device that allows the creation of two or more different tissues integrated with the natural phenotype, using an integrated and continuous 3D support structure. | 2017-10-05 |
20170283757 | LIDDED CELL CULTURE DEVICES WITH IMPROVED HANDLING PERFORMANCE AND METHODS FOR USING SAME - Cell culture devices are described herein that have notched lids, notched lids with corresponding gripping pads included on their bases, or gripping tabs included on their bases to minimize or eliminate the need for a user to contact a lid when attempting to lift or move a lidded cell culture device. In addition, methods for using the cell culture devices are also described herein. | 2017-10-05 |
20170283758 | CULTURE CONTAINER AND METHOD FOR MANUFACTURING CULTURE CONTAINER - A culture container for activating lymphocytes includes immobilized anti-CD3 antibodies and an anti-CD3 antibody solution including anti-CD3 antibodies, wherein the culture container is formed in a bag-like shape and is formed of a soft-packaging material, the immobilized anti-CD3 antibodies are immobilized at a density of 10 to 300 ng/cm | 2017-10-05 |
20170283759 | Nanocomposite Scaffold for the In Vitro Isolation of Cells - The present invention is directed to devices, methods and kits for cell-specific sorting of cells from a mixed population, e.g., from a tumor sample. Aspects of the invention combine aligned, electrospun microfibers with drug-or protein-releasing nanospheres to isolate cancer cells from tumor biopsies. | 2017-10-05 |
20170283760 | CELL CULTURE MONITORING SYSTEM WITH LOW POWER CONSUMPTION - An improved cell culture monitoring system and method that detects cell growth and concentration in a dynamic environment of incubator/shaker. In order to reduce power consumption and make a wireless cell culture monitoring system practical, several methods of temperature compensation are used to replace a method of controlling the temperature of sensing module. Furthermore its power consumption can be significantly reduced by using an adaptive and synchronized light pulse detection technique. | 2017-10-05 |
20170283761 | System, Device and Method for Electroporation of Cells - A system, device and method for electroporation of living cells and the introduction of selected molecules into the cells utilizes a fluidic system where living cells and biologically active molecules flow through a channel that exposes them to electric fields, causing the molecules to be transferred across the cell membrane. The device is structured in a manner that allows precise control of the cells location, motion, and exposure to electric fields within the flow channel device. The method is particularly well suited for the introduction of DNA, RNA, drug compounds, and other biologically active molecules into living cells. | 2017-10-05 |
20170283762 | METHOD OF ISOLATING PROBIOTICS OF HUMAN INTESTINE - A method of isolating probiotics of human intestine, including preparing bases for culturing liquid and solid mucoproteins; and filtering, which includes collecting human feces, planting the human feces in the base for culturing liquid mucoprotein, culturing the human feces to obtain microbial liquid, using the microbial liquid as template, pouring the microbial liquid into tubes, subjecting the tubes to a PCR test, selecting the tubes tested positive in the PCR test, pouring the microbial liquid in the positive tubes into the base for culturing solid mucoprotein, culturing the microbial liquid to obtain first colonies, planting the colonies in a chocolate tablet, culturing the first colonies to obtain second colonies, planting the second colonies in a Columbia blood tablet, purifying the second colonies to obtain third colonies, using 16sRNA common primers to identify the third colonies in the PCR, and isolating probiotics. | 2017-10-05 |
20170283763 | METHODS AND SYSTEM FOR INTERFERING WITH VIABILITY OF BACTERIA AND RELATED COMPOUNDS AND COMPOSITIONS - Provided herein are methods and systems for interfering with viability of bacteria and related compounds and compositions. | 2017-10-05 |
20170283764 | PROCESSING OF PLANT MATERIAL INTO BACTERIAL FEEDSTOCK - Methods and compositions relating to processing of plant material into bacterial feedstock, such as bacterial feedstock suitable for nanocellulose production, are disclosed. Cellulosic plant fiber may be contacted with a catalyst such as an acid catalyst or an enzymatic catalyst or both, and the mixture can be hydrolyzed into a hydrolysate. The hydrolysate may be used to form a culture medium which can be used to support bacterial growth to form the nanocellulose. | 2017-10-05 |
20170283765 | Partial Adaption for Butanol Production - Provided herein are processes for producing an improved culture of cells comprising an engineered butanol biosynthetic pathway. The processes comprise (a) providing a cell culture of recombinant microorganisms comprising an engineered butanol biosynthetic pathway, wherein the engineered butanol biosynthetic pathway is minimal or not activated; and (b) growing the culture of recombinant microorganisms under adaptive conditions whereby pathway activation is increased to produce an improved cell culture and whereby said improved cell culture is capable of continuing to grow in fermentation. | 2017-10-05 |
20170283766 | METHOD FOR FABRICATION OF MICROWELLS FOR CONTROLLED FORMATION OF 3-DIMENSIONAL MULTICELLULAR-SHAPES - Using 3D printing, a microwell is formed by providing a plurality of masks, each mask representing a cross-section of a layer of the concave structure. Progressive movement of a projection plane exposes a pre-polymer solution to polymerizing radiation modulated by the masks to define the layers of the microwell, where each layer is exposed for a non-equal exposure period as determined by a non-linear factor. In a preferred embodiment, a first portion of the masks are base layer masks, which are exposed for a longer period than subsequent exposure periods. Shapes of the microwells, which may include circular, square, annular, or other geometric shapes, and their depths, are selected to promote aggregation behavior in the target cells, which may include tumor cells and stem cells. | 2017-10-05 |
20170283767 | THREE-DIMENSIONAL CELL CULTURE SYSTEM AND CELL CULTURE METHOD USING SAME - The present invention relates to a composition for preserving cells and a cell preservation method and, more specifically: to a composition for preserving cells, containing, as active ingredients, a plant-derived recombinant human serum albumin and a plant peptide, which maintain a high cell survival rate while maintaining animal-free and xeno-free properties and are stable without changes in cell morphology or a surface expression factor during the short term preservation of cells such as stem cells or primary cultured cells; and a cell preservation method using the same. | 2017-10-05 |
20170283768 | METHOD FOR INDUCING THREE-DIMENSIONAL OSTEOGENIC DIFFERENTIATION OF STEM CELLS USING HYDROGEL - The present invention relates to a method for inducing osteogenic differentiation of mesenchymal stem cells and, more particularly, to a short-time osteogenic differentiation method of culturing cells using a porous membrane and a biodegradable synthetic biogel, whereby the cells do not contact a cell culture container. The present invention can significantly shorten the induction period of osteogenic differentiation, compared to the conventional osteogenic differentiation method, and has an effect of the cells being easily separable after differentiation as well. | 2017-10-05 |
20170283769 | Modified Cells Evoking Reduced Immunogenic Responses - The present disclosure describes composition, methods, and systems associated with a genetically modified stem cell. The modified stem cell includes a reduced amount of Major Histocompatibility Complex II (MHC II) as compared to a corresponding wild-type cell. Further, the modified cell has decreased immunogenicity as compared to the corresponding wild-type cell. | 2017-10-05 |
20170283770 | DOWNREGULATION OF SINE/ALU RETROTRANSPOSON TRANSCRIPTION TO INDUCE OR RESTORE PROLIFERATIVE CAPACITY AND/OR PLURIPOTENCY TO A STEM CELL - In certain embodiments methods are provided for inducing and/or restoring and/or maintaining a non-senescent phenotype, or aspects thereof (e.g., proliferative capacity and/or pluripotency) in a mammalian cell. The methods typically involve reducing the level or activity of SINE/Alu retrotransposon transcripts in the cell in an amount sufficient to induce or restore proliferative capacity and/or pluripotency to said mammalian cell. | 2017-10-05 |
20170283771 | Methods of in vitro Oocyte Development - Methods of preparing ovarian tissue for primordial follicle growth are presented comprising the steps: providing an ovarian tissue sample comprising cortical tissue and stromal tissue; removing damaged tissue from the ovarian tissue sample where present; removing excess stromal tissue from the ovarian tissue sample where present; and then mechanically stretching the ovarian tissue sample along at least one dimension of the ovarian tissue sample, such that the size of the ovarian tissue sample along the at least one dimension is increased by at least 10%. Methods of growing viable oocyte in vitro, and methods of preparing individual ovarian follicles for growth are also presented. | 2017-10-05 |
20170283772 | METHODS FOR DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS TO BRAIN MICROVASCULAR ENDOTHELIAL CELLS - Methods for generating functional brain microvascular endothelial cells (BMECs) under chemically defined, serum-free conditions are provided. In particular, efficient and cost-effective methods for generating functional BMECs under chemically defined culture conditions are provided. BMECs obtained according to the methods provided herein are suitable for in vitro blood brain barrier (BBB) formation. | 2017-10-05 |
20170283773 | METHODS FOR IMPROVING PROLIFERATION AND STEMNESS OF LIMBAL STEM CELLS - Provided are methods for improving the proliferation and sternness of limbal stem cells (LSCs) by adding a Wnt inhibitor to a medium for limbal explant cultures. | 2017-10-05 |
20170283774 | METHODS FOR EFFICIENT DERIVATION OF HUMAN MOTOR NEURONS FROM DIVERSE SPINAL REGIONS - Described herein are chemically defined, adherent culture protocols for generating functional motor neurons characteristic of diverse hindbrain and spinal cord regions, with high efficiency. | 2017-10-05 |
20170283775 | Compositions and Methods for Treatment of Cancer - The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain. | 2017-10-05 |
20170283776 | REPROGRAMMING CELLS - The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a 3′-phosphoinositide-dependent kinase-1 (PDK1) activator or a compound that promotes glycolytic metabolism as well as other small molecules. | 2017-10-05 |
20170283777 | MAMMALIAN CHIMERIC COMPLEMENTATION - Disclosed herein are chimeric mammals, such as a chimeric mammal comprising cells derived from at least a first mammal and a second mammal, wherein the cells from the first mammal comprise a genetic modification at one or more loci and the cells from the second mammal form at least one organ or tissue, wherein the first and second mammals are different species. | 2017-10-05 |
20170283778 | ARTIFICIAL PERITONEAL TISSUE AND METHOD FOR PRODUCING SAME - The present disclosure relates to: an artificial peritoneal tissue comprising a cellular tissue and a mesothelial cell layer that covers the surface of the cellular tissue, wherein the cellular tissue comprises a fibroblast, an extracellular matrix, and a vascular endothelial cell and/or a lymphatic endothelial cell each capable of forming a lumen; and a method for producing the artificial peritoneal tissue. | 2017-10-05 |
20170283779 | BACTERIOPHAGE ENGINEERING METHODS - The present disclosure provides methods and kits for generating recombinant bacteriophage genomes. | 2017-10-05 |
20170283780 | FATTY ACID DESATURASES FROM PRIMULA - The invention relates generally to methods and compositions concerning desaturase enzymes that modulate the number and location of double bonds in long chain poly-unsaturated fatty acids (LC-PUFA's). In particular, the invention relates to methods and compositions for improving omega-3 fatty acid profiles in plant products and parts using desaturase enzymes and nucleic acids encoding for such enzymes. In particular embodiments, the desaturase enzymes are | 2017-10-05 |
20170283781 | BIOCATALYSTS AND METHODS FOR SYNTHESIZING DERIVATIVES OF TRYPTAMINE AND TRYPTAMINE ANALOGS - The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents. | 2017-10-05 |
20170283782 | TRPV1 MODULATORY GENE PRODUCT THAT AFFECTS TRPV1-SPECIFIC PAIN BEHAVIORAL RESPONSES IDENTIFIED IN A FUNCTIONAL SCREEN OF AN HSV-BASED cDNA LIBRARY - The invention provides a method for ameliorating chronic pain signaling involving transient receptor potential cation channel subfamily V member 1 (TRPV1) by expressing PP1α in neurons. The invention also provides HSV vectors for expressing PP1α within neurons and compositions comprising such vectors. | 2017-10-05 |
20170283783 | HUMAN BETA-ADRENERGIC RECEPTOR KINASE POLYPEPTIDE AND METHODS - Various embodiments of the invention provide human kinases and phosphatases (KPP) polypeptides and polynucleotides which identify and encode KPP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KPP. | 2017-10-05 |
20170283784 | IMPROVED NITRILE HYDRATASE - Provided is a novel improved nitrile hydratase with improved resistance to amide compounds under high temperatures. Specifically provided is a nitrile hydratase having at least one amino acid mutation selected from (a) to (d) below, in the amino acid sequence expressed in SEQ ID NO:50 (X | 2017-10-05 |
20170283785 | SMALL ENZYME-CONTAINING GRANULES - The invention provides small enzyme-containing granules having an inorganic salt core and an enzyme-containing layer coated over the core, and methods for producing such granules. The majority of the enzyme granules are less than 300 μm in diameter. The granules are suitable for incorporation into compositions such as cleaning, textile processing, and animal feed compositions. | 2017-10-05 |
20170283786 | METHOD FOR PREPARING KAOLIN IMMOBILIZED GY2B BACTERIA AND APPLICATION THEREOF - Provided are a method for preparing kaolin immobilized GY2B bacteria and use thereof. | 2017-10-05 |
20170283787 | METHOD FOR NON-ENZYMATIC COMBINATION OF NUCLEIC ACID CHAINS - Provided, as a technique for binding a nucleic acid chain and a nucleic acid chain by a natural structure or an analogous structure thereto, is a non-enzymatic nucleic acid chain binding method, which is a method for binding a nucleic acid chain and a nucleic acid chain not via an enzymatic reaction, including a step of reacting a nucleic acid chain having a phosphorothioate group and a nucleic acid chain having a hydroxyl group or amino group in the presence of an electrophile. | 2017-10-05 |
20170283788 | EXTRACTION OF cfDNA FROM BIOLOGICAL SAMPLES - Focused acoustic treatment of samples including a target biomolecule, such as cfDNA, may aid in the recovery of the biomolecule from a sample. cfDNA in a sample, whether chemically stabilized or not, may be linked or otherwise bound to histones or other proteins, e.g., by hydrogen bonds of histones or chaperone proteins to DNA and/or covalent crosslinks of such proteins to the DNA. Focused acoustic energy may remove or disrupt such links, aiding in isolation of the cfDNA from the sample. | 2017-10-05 |
20170283789 | METHODS FOR COLLECTING CERVICAL-VAGINAL FLUIDS AND ISOLATING EXOSOME AND MICROVESICLES FOR MOLECULAR ANALYSIS - The present disclosure relates to methods of collecting cervical-vaginal fluid exosomes and microvesicles and isolating corresponding mRNA. In particular, certain embodiments relate to the method of collecting the cervical-vaginal fluids with a tampon and releasing the cells, exosomes and microvesicles using excess buffer and a syringe or syringe-like device. The resulting expunged fluid can be applied to a filter device that is capable of capturing exosomes and microvesicles. Nucleic acids such as mRNA can be isolated from the cervical-vaginal fluid exosome and microvesicles using an oligo(dT)-coated plate designed to accommodate the filter device and then used for further molecular analysis. Quantification of the collected nucleic acids may then be used in the diagnosis and/or treatment of gynecological diseases or conditions. | 2017-10-05 |
20170283790 | Sample Processing Methods - A method of processing a sample may include introducing a sample into a vessel, the vessel having proximal and distal ends, the sample being introduced into the proximal end of the vessel; incubating the sample in the vessel with a substance capable of specific binding to a preselected component of the sample; propelling components of the incubated sample, other than the preselected component, toward the proximal end of the vessel by clamping the vessel distal to the incubated sample and compressing the vessel where the incubated sample is contained; propelling the preselected component toward a distal segment of the vessel by clamping the vessel proximal to the preselected component and compressing the vessel where the preselected component is contained; and mixing the preselected component with a reagent in the distal segment of the vessel. | 2017-10-05 |
20170283791 | NUCLEIC ACID-BINDING SOLID-PHASE CARRIER AND NUCLEIC ACID EXTRACTION METHOD - A nucleic acid-binding solid-phase carrier includes a magnetic particle of an amorphous metal containing Fe, Cr, Si, and B, and a silicon oxide film provided on the surface of the magnetic particle. | 2017-10-05 |
20170283792 | Nucleic Acid Purification Cartridge - A microfluidic device is disclosed having an enclosed chamber containing a filter for purifying biological or chemical analytes from a complex biological sample, said chamber housing a plurality of ports in addition to said filter, as follows: a first port enabling gas communication of the chamber with a vacuum generator, via a first flow path; a second port enabling liquid communication of the chamber with one or more reservoirs, via a second flow path; a third port enabling gas and liquid communication of the chamber with both one or more receiving containers and a vacuum generator, via a third flow path; and a filter located between the third port and both the first and second port, so that a fluid entering the chamber through the first and/or second port and exiting the chamber through the third port flows through the filter. The invention also relates to a method using the microfluidic device. | 2017-10-05 |
20170283793 | DNA SEQUENCE AND A MUTATOR INSERTION SEQUENCE FOR INCREASING MUTATION RATE - The invention relates to a DNA sequence for increase of a mutation rate over a specific region of DNA. Particularly, the invention provides a unique guanine nucleotide sequence and a mutator insertion sequence incorporated with the guanine nucleotide sequence and their applications in increasing a mutation rate. | 2017-10-05 |
20170283794 | METHODS FOR SELECTING AND AMPLIFYING POLYNUCLEOTIDES - The invention provides methods for generating a nucleic acid library. Target-specific primer-probes are hybridized to a target nucleic acid fragment to create a hybridization product. Each of the target-specific primer-probes comprises a target-specific sequence and a first adaptor sequence. The target nucleic acid fragment comprises a target genomic region of interest, wherein said target genomic region of interest comprises an exon of a gene and the target-specific primer-probes are tiled across the exon of the gene. The target nucleic acid fragment further comprises a second adaptor sequence different from said first adaptor sequence. Following hybridization, the target-specific primer-probes are extended to create double-stranded extension products and further amplified, thereby generating the nucleic acid library. | 2017-10-05 |
20170283795 | PHOSPHATIDYLINOSITOL-3-KINASE NUCLEIC ACIDS AND USES THEREOF - Disclosed herein are molecules and pharmaceutical compositions that mediate RNA interference against PI3K. Also described herein include methods for treating a disease or disorder that comprises a molecule or a pharmaceutical composition that mediate RNA interference against PI3K. | 2017-10-05 |
20170283796 | GENE EXPRESSION ANALYSIS METHOD USING TWO DIMENSIONAL cDNA LIBRARY - The present invention provides a method and/or means for collecting and analyzing an individual cell in a tissue, and at the same time, quantitatively monitoring the expression levels of various genes while keeping two-dimensional information in the tissue. Specifically, the present invention provides a method comprising preparing a cDNA library from mRNA while keeping two-dimensional cellular distribution information and obtaining the gene expression levels at any site or all sites at a level of single cell. More specifically, the present invention provides a method comprising preparing a cDNA library in a sheet-form from mRNA while keeping two-dimensional cellular distribution information and repeatedly using the cDNA library in the detection of the gene expression, thereby allowing measurement of the expression distribution for a number of genes at a high accuracy. | 2017-10-05 |
20170283797 | Compositions and methods relating to synthetic RNA polynucleotides created from synthetic DNA oligonucleotides - Compositions and methods are provided for forming a single RNA polynucleotide from a plurality of DNA oligonucleotides in a single reaction chamber using combined reagents in a single step reaction. DNA polymerase, RNA polymerase and single stranded (ss) DNA oligonucleotides are combined where each DNA oligonucleotide has one or more sequence modules, wherein one sequence module in the first ss DNA oligonucleotide is complementary to a sequence module at the 3′ end of the second ss DNA oligonucleotide; and wherein a second module on the first ss DNA oligonucleotide is an RNA polymerase promoter sequence; and forming a single RNA polynucleotide, excluding the RNA promoter sequence, derived from the first and second DNA oligonucleotides | 2017-10-05 |
20170283798 | TTV MIRNA SEQUENCES AS AN EARLY MARKER FOR THE FUTURE DEVELOPMENT OF CANCER AND AS A TARGET FOR CANCER TREATMENT AND PREVENTION - Described are TTV miRNAs and probes and primers comprising part of said TTV miRNA polynucleic acid. The use of said compounds for diagnosis of cancer or predisposition of cancer is also described. | 2017-10-05 |
20170283799 | COMPOSITIONS FOR TREATING MUSCULAR DYSTROPHY - Improved compositions and methods for treating muscular dystrophy by administering antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon skipping are described. | 2017-10-05 |
20170283800 | DOWNREGULATING MIR-132 FOR THE TREATMENT OF LIPID RELATED DISORDERS - A method of treating a lipid-related disorder in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of a polynucleotide agent which is substantially complementary to a nucleotide sequence of human miR-132, thereby treating the lipid related disorder in the subject. | 2017-10-05 |
20170283801 | THERAPEUTIC COMPOSITIONS - This application relates to therapeutic siRNA agents and methods of making and using the agents. | 2017-10-05 |
20170283802 | DESIGN OF NUCLEIC ACID BINDING MOLECULES WITH NON-WATSON CRICK AND NON-CANONICAL PAIRING BASED ON ARTIFICIAL MUTATION CONSENSUS SEQUENCES TO COUNTER ESCAPE MUTATIONS - Universal nucleic acid binding molecules (e.g., antisense oligonucleotides or RNAi molecules) having an inhibitory or activating nucleic acid sequence which binds a receiving nucleic acid sequence (e.g., RNA or DNA) are provided. In some embodiments, the universal nucleic acid binding molecules bind the receiving nucleic acid sequence (e.g., RNA or DNA) via at least one non-Watson Crick or non-canonical paired base. | 2017-10-05 |
20170283803 | RNA INTERFERENCE COMPOSITIONS TARGETING HEAT SHOCK PROTEIN 90 AND METHODS OF USE THEREOF - This disclosure relates to RNA interference (RNAi) compositions that target expression of heat shock protein 90 (HSP90) in a subject. Polymeric delivery devices for providing the RNAi compositions are also described, as are methods of treating cancer using the described RNAi compositions. | 2017-10-05 |
20170283804 | ANTISENSE COMPOUNDS AND USES THEREOF - The present disclosure provides methods for sensitizing a cell for modulation by oligomeric compounds. Certain such oligomeric compounds are useful for hybridizing to a complementary nucleic acid, including but not limited, to nucleic acids in a cell. In certain embodiments, hybridization results in modulation of the amount activity or expression of the target nucleic acid in a cell. | 2017-10-05 |
20170283805 | Antisense RNA for Treating Cancer and Inhibition of Metastasis and Vectors for Antisense Sequestration - Provided is the use of antisense RNA and methods for the treatment, diagnosis and prophylaxis of cancer comprising administering said antisense RNA, particularly miRs 15 and 16 to a patient in need thereof. | 2017-10-05 |
20170283806 | KRAS NUCLEIC ACIDS AND USES THEREOF - Disclosed herein are molecules and pharmaceutical compositions that mediate RNA interference against KRAS. Also described herein include methods for treating a disease or disorder that comprises a molecule or a pharmaceutical composition that mediate RNA interference against KRAS. | 2017-10-05 |
20170283807 | COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF PROSTATE CANCER - The invention provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating subjects having TMPRSS2:ERG positive prostate cancer, which we show is amenable to therapeutic treatment with a PRMT5 inhibitor. Kits, methods of screening for candidate PRMT5 inhibitors, and associated methods of treatment are also provided. | 2017-10-05 |
20170283808 | MIR-520B SEQUENCE FOR INHIBITING CANCER GROWTH AND SPREAD AND MEDICINE THEREFOR - A miR-520b sequence for inhibiting cancer growth and spread includes miR-520b sequence for inhibiting cancer growth and spread wherein the miR-520b sequence is 5′-AAAGUGCUUCCUUUUAGAGGGtt-3′ of SEQ ID NO:2. A medicine for inhibiting cancer growth and spread includes a medicinal preparation including miR-520b substrate and medical agent wherein the miR-520b substrate is miR-520b sequence and has concentration of 50 μM, and the miR-520b sequence is 5′-AAAGUGCUUCCUUUUAGAGGGtt-3′ of SEQ ID NO:2. | 2017-10-05 |
20170283809 | RECOMBINANT MICROORGANISM PRODUCING ALKENES FROM ACETYL-COA - Disclosed is a recombinant microorganism comprising endogenous enzymes that convert CO and/or CO | 2017-10-05 |
20170283810 | Nucleic acid constructs for presentation of CD4 and CD8 epitopes, cellular transfection and uses thereof - The invention relates to constructs, cells and methods for modulating the immune system that optimize presentation of CD4 and CD8 epitopes to antigen-presenting cells and transfection into cells. Epitopes to either self antigens or non-self antigens can be used to optimize either a tolerance or immunogenicity to those epitopes, respectively. Certain new constructs encode one or more dominant, disease-driving epitopes (CD4) targeted for MHCII processing within the endosomes of a cell and one or more epitopes (CD8) targeted for MHCI processing within the cytosol of the cell, to produce the maximum antigen/epitope presentation in the immune system, and further include an MHCII activator sequence. Alternatively, the new constructs encode CD4 and CD8 epitopes operably linked to a secretion signal. | 2017-10-05 |
20170283811 | Methods for Increasing the Stability of Production of Compounds in Microbial Host Cells - Methods for increasing the genetic stability of genetically enhanced microbial host cells capable of producing a compound of interest are disclosed. | 2017-10-05 |
20170283812 | METHOD OF CREATING INDUSTRIAL STREPTOMYCES WITH CAPABILITY TO GROW ON CELLULOSIC POLYSACCHARIDE SUBSTRATES - A heterologous gene cassette useful for creating | 2017-10-05 |
20170283813 | SYSTEMS, COMPOSITIONS, AND METHODS FOR REDUCING LEVELS OF CANDIDATUS LIBERIBACTER SOLANACEARUM IN POTATO - The present disclosure relates, in some embodiments, to a method of reducing levels of | 2017-10-05 |
20170283814 | BIOLOGICAL CONTROLS OF COLEOPTERAN PESTS - Disclosed are double stranded RNA molecules that are toxic to coleopteran insects. In particular, dsRNA molecules that capable of interfering with pest IAP genes and that are toxic to the target pest are provided. Further, methods of making and using the interfering RNA, for example in transgenic plants to confer protection from insect damage are disclosed. | 2017-10-05 |
20170283815 | COMPOSITIONS AND METHODS FOR MODULATING EXPRESSION OF NUCLEIC ACIDS - The invention relates to synthetic miRNA precursor molecules and methods for the use of the miRNA precursor molecules in modulating the expression of target polynucleotides | 2017-10-05 |
20170283816 | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA) - The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism. | 2017-10-05 |
20170283817 | Polypeptides Having Beta-Xylosidase Activity and Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having beta-xylosidase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2017-10-05 |
20170283818 | COMPOSITIONS AND METHODS FOR PRODUCING STARCH WITH NOVEL FUNCTIONALITY - This invention disclosure relates to novel maize starch. The starch can be made from the newly developed waxy sugary-2 double-mutant maize that has low activity of Granule Bound Starch Synthase I (GBSSI), which results in low amylose level. The starch from newly developed waxy sugary-2 double-mutant is freeze-thaw stable and has high viscosity. In comparison with the starch of the existing waxy sugary-2 double-mutant maize, the new waxy sugary-2 double-mutant maize starch showed, inter alia, improved pasting profile, starch granule integrity, larger starch granule size, and higher viscosity. | 2017-10-05 |