40th week of 2017 patent applcation highlights part 33 |
Patent application number | Title | Published |
20170283819 | Single Nucleotide Polymorphism (SNP) Markers for Stevia - varieties with high a content of RebD, a high content of RebM, and a high content of RebD and RebM containing various SNP markers and UGT isoforms, are disclosed. Methods of screening for the SNPs are also disclosed as well as for using the SNPs in marker assisted breeding. Further provided are methods for introgressing the disclosed SNPs associated with high RebD and high RebM into | 2017-10-05 |
20170283820 | HIGH OLEIC ACID SOYBEAN SEEDS - A genetically altered soybean plant, its parts (including seeds, cells, flowers, pollen), and its progeny produces at least one altered delta-twelve fatty acid desaturase 2 enzyme (FAD2), namely an altered FAD2-1A, an altered FAD2-1B, or both. This genetically altered soybean plant has reduced FAD2 enzymatic activity in its seeds, thereby producing higher amounts of oleic acid in its seeds than a wild-type soybean plant produces. Methods of generating this genetically altered soybean plant are provided. | 2017-10-05 |
20170283821 | METHODS TO IMPROVE PLANT-BASED FOOD AND FEED - The present invention describes an alternative approach to increase Taurine (Tau) or methionine (Met) production in eukaryotes, namely by the insertion of components of a sulfur-metabolic pathway and Tau- or Met-binding proteins in organisms where the peptides do not exist or have not clearly been identified. The invention describes methods for the use of polynucleotides that encode functional cysteine dioxygenase (CDO) alone, sulfinoalanine decarboxylase (SAD) alone or CDO and SAD polypeptides in combination with functional Tau- or Met-binding proteins in plants to increase Tau or Met production. The preferred embodiment of the invention is in plants but other organisms may be used. Increased Tau or Met availability will improve nutritional value of the crop. | 2017-10-05 |
20170283822 | COMPOSITIONS AND METHODS FOR PRODUCING POLYPEPTIDES WITH A MODIFIED GLYCOSYLATION PATTERN IN PLANT CELLS - The A method of modifying a glycosylation pattern of a polypeptide-of-interest in a plant or plant cell is provided. The method comprising expressing in a plant or plant cell transformed to express at least one glycosidase in a subcellular compartment, a nucleic acid sequence encoding the polypeptide-of-interest, such that the at least one glycosidase and the polypeptide-of-interest are co-localized to the subcellular compartment of the plant or plant cell, thereby modifying the glycosylation pattern of the polypeptide-of-interest in the plant or plant cell. | 2017-10-05 |
20170283823 | GENE FOR INCREASING THE PRODUCTION OF PLANT BIOMASS AND/OR SEEDS AND METHOD FOR USE THEREOF - A technique by which the production of plant biomass can be significantly increased is provided. A protein phosphatase 2C gene having 3 consensus sequences comprising the amino acid sequences shown in SEQ ID NOS: 1-3 from the N-terminal side in such order is over-expressed. | 2017-10-05 |
20170283824 | GENE FOR INCREASING THE PRODUCTION OF PLANT BIOMASS AND/OR SEEDS AND METHOD FOR USE THEREOF - A technique by which the production of plant biomass can be significantly increased is provided. A protein phosphatase 2C gene having 3 consensus sequences comprising the amino acid sequences shown in SEQ ID NOS: 1-3 from the N-terminal side in such order is over-expressed. | 2017-10-05 |
20170283825 | GENE FOR INCREASING THE PRODUCTION OF PLANT BIOMASS AND/OR SEEDS AND METHOD FOR USE THEREOF - A technique by which the production of plant biomass can be significantly increased is provided. A protein phosphatase 2C gene having 3 consensus sequences comprising the amino acid sequences shown in SEQ ID NOS: 1-3 from the N-terminal side in such order is over-expressed. | 2017-10-05 |
20170283826 | PHYTOPHTHORA RESISTANT PLANTS BELONGING TO THE SOLANACEAE FAMILY - The present invention relates to a plant belonging to the Solanaceae family wherein said plant comprises a genetic trait providing | 2017-10-05 |
20170283827 | FSH NUCLEIC ACID MOLECULES TO CONTROL INSECT PESTS - This disclosure concerns nucleic acid molecules and methods of use thereof for control of insect pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in insect pests, including coleopteran and/or hemipteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of insect pests, and the plant cells and plants obtained thereby. | 2017-10-05 |
20170283828 | METHODS FOR GENETIC CONTROL OF INSECT INFESTATIONS IN PLANTS AND COMPOSITIONS THEREOF - The present invention relates to control of pest infestation by inhibiting one or more biological functions. The invention provides methods and compositions for such control. By feeding one or more recombinant double stranded RNA molecules provided by the invention to the pest, a reduction in pest infestation is obtained through suppression of gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and to particular combinations of transgenic pesticidal agents for use in protecting plants from pest infestation. | 2017-10-05 |
20170283829 | SPRR1A AS A GENETIC TARGET FOR TREATING NEURODEGENERATIVE DISEASES - This invention relates to the prevention and treatment of neurodegenerative diseases by administering compositions that increase the activity of a small proline-rich repeat 1 A protein (Sprr1A), or derivative thereof to the brain. Specifically, the compositions may comprise a nucleic acid molecule encoding a Sprr1A protein or a biologically-active portion thereof. The neurodegenerative disease may be Parkinson's Disease, Alzheimer's disease, amyotrophic lateral sclerosis, or traumatic brain injury. | 2017-10-05 |
20170283830 | COMPOSITIONS FOR ENHANCING TARGETED GENE EDITING AND METHODS OF USE THEREOF - Compositions and methods for enhancing targeted gene editing and methods of use thereof are disclosed. In the most preferred embodiments, gene editing is carried out utilizing a gene editing composition such as triplex-forming oligonucleotides, CRISPR, zinc finger nucleases, TALENS, or others, in combination with a gene modification potentiating agent such as stem cell factor (SCF), a CHK1 or ATR inhibitor, or a combination thereof. A particular preferred gene editing composition is triplex-forming peptide nucleic acids (PNAs) substituted at the γ position for increased DNA binding affinity. Nanoparticle compositions for intracellular delivery of the gene editing composition are also provided and particular advantageous for use with in vivo applications. | 2017-10-05 |
20170283831 | PROTECTED GUIDE RNAS (PGRNAS) - The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems, wherein the guide sequence is modified by secondary structure to increase the specificity of the CRISPR-Cas system and whereby the secondary structure can protect against exonuclease activity and allow for 5′ additions to the guide sequence. | 2017-10-05 |
20170283832 | TRANSFORMED SYNECHOCOCCUS ELONGATUS STRAIN HAVING CAPABILITY OF PRODUCING SQUALENE FROM CARBON DIOXIDE AND METHOD FOR PRODUCING SQUALENE USING THE SAME - The present specification discloses a transformed | 2017-10-05 |
20170283833 | MULTIPLE TANK HIGH SOLIDS ANAEROBIC DIGESTER - A multi-stage anaerobic digester is designed to treat a high solids, stackable feedstock. The system may also receive a pumpable feedstock such as a slurry or sludge. In a first stage, the digestate circulates in one direction around a raceway such that the digestate may pass a feed inlet multiple times before leaving the first tank. An optional side stream loop withdraws fibrous material from near the top of the raceway and return digestate with chopped fibers, preferably lower and further along the raceway. An outlet from the raceway located near, but upstream of, the feed inlet discharges partially digested substrate to a second stage, which is operated as a stirred tank reactor. The two stages may be provided in a single tank with an internal wall separating a ring shaped outer portion from a cylindrical inner portion. The digester may be operated in a thermophilic temperature range. | 2017-10-05 |
20170283834 | Processes for Producing A Fermentation Product Using A Fermenting Organism - The present invention relates to processes for producing a fermentation product, such as ethanol, from starch-containing material; wherein an acid having a pKa in the range from 3.75 to 5.75 is present or added in fermentation so that the acid concentration in fermentation is maintained between above 0 (zero) and 100 mmoles/L fermentation medium and wherein the acid is added before the exponential growth phase of the fermenting organism. | 2017-10-05 |
20170283835 | VARIANTS OF GAL2 TRANSPORTER AND THEIR USES - The present invention relates to polypeptides which are Gal2 variants comprising at least one amino acid substitution at a position corresponding to T354, and optionally further amino acid substitution(s). The present invention further relates to nucleic acid molecules encoding the polypeptides and to host cells containing said nucleic acid molecules. The present invention further relates to a method for the production of bioethanol and/or other bio-based compounds, comprising the expression of said nucleic acid molecules, preferably in said host cells. The present invention also relates to the use of the polypeptides, nucleic acids molecule or host cells for the production of bioethanol and/or other bio-based compounds, and/or for the recombinant fermentation of biomaterial containing pentose(s), preferably D-xylose and/or L-arabinose. | 2017-10-05 |
20170283836 | Microbial Synthesis Of Aldehydes And Corresponding Alcohols - An improved process for alcohol production includes microbial fermentation using a genetically modified microorganism to produce substantial quantities of aldehydes that are stripped from the fermentation medium and condensed. So produced aldehydes are converted in an ex vivo process to corresponding alcohols. | 2017-10-05 |
20170283837 | BIOENZYMATIC SYNTHESIS OF THC-v, CBV AND CBN AND THEIR USE AS THERAPEUTIC AGENTS - The present invention provides methods for producing cannabinoids. More specifically, the invention is directed to the bio-enzymatic synthesis of THC-v, CBV and CBN by contacting a compound according to Formula I with a cannabinoid synthase enzyme. Also described is a system for producing these pharmaceutically important cannabinoids and the use of such cannabinoids as therapeutic agents. | 2017-10-05 |
20170283838 | OIL COMPOSITION AND METHOD OF RECOVERING SAME - The present invention generally relates to oil compositions and methods of producing such oil compositions. More particularly, the present invention relates to an oil composition recovered from a fermentation product as well as methods of recovering such oil compositions for use in various processes such as bio-diesel production as well as in various edible applications. | 2017-10-05 |
20170283839 | DESATURASES AND METHODS OF USING THEM FOR SYNTHESIS OF POLYUNSATURATED FATTY ACIDS - The amino acid and nucleic acid sequences of a Δ | 2017-10-05 |
20170283840 | METHOD FOR PREPARING AN AQUEOUS ACRYLAMIDE SOLUTION HAVING A LOW ACRYLIC ACID CONCENTRATION - The present invention relates to methods for preparing an aqueous acrylamide solution having a low acrylic acid concentration. In addition, the present invention relates to methods for reducing the acrylic acid concentration of an aqueous acrylamide solution. The methods involve a bioconversion of acrylonitrile to acrylamide in the presence of a biocatalyst, wherein during the bioconversion the content of acrylonitrile is maintained at 0.3 w/w % or more referred to the total weight of the composition in the reactor. Also provided is an aqueous acrylamide solution which is obtained by the methods of the present invention. Furthermore, the present invention is related to an acrylamide homopolymer or copolymer obtained by polymerizing the acrylamide of the aqueous solution. | 2017-10-05 |
20170283841 | METHOD FOR PRODUCING PATCHOULOL AND 7-EPI-ALPHA-SELINENE - The present invention provides a method of producing patchoulol and 7-epi-α-selinene, said method comprising contacting at least one polypeptide with farnesyl phyrophosphate (FPP). In particular, said method may be carried out in vitro or in vivo to produce patchoulol and 7-epi-α-selinene, compounds which can be useful in the field of perfumery. The present invention also provides the amino acid sequence of a polypeptide useful in the method of the invention. A nucleic acid encoding the polypeptide of the invention and an expression vector containing said nucleic acid are also part of the present invention. A non-human host organism or a cell transformed to be used in the method of producing patchoulol and 7-epi-α-selinene is also an object of the present invention. | 2017-10-05 |
20170283842 | METHODS OF PRODUCING BACTERIAL NANOCELLULOSE FROM CASSAVA BAGASSE - Methods, compositions, systems and kits relating to processing of cassava bagasse into bacterial feedstock, such as bacterial feedstock suitable for nanocellulose production, are disclosed. Cassava bagasse may be contacted with an acid catalyst or an enzymatic catalyst to produce a hydrolysate, which can be used to form a pre-fermentation medium. Incubation of the pre-fermentation medium with a first population of microorganisms yields a supernatant enriched in reducing sugars, which may be used to form a culture medium which can be used to support growth of a second population of microorganisms to form the nanocellulose. | 2017-10-05 |
20170283843 | Carbohydrate Binding Module Variants And Polynucleotides Encoding Same - The present invention relates to cellobiohydrolase variants and carbohydrate binding module variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants. | 2017-10-05 |
20170283844 | METHODS OF PRODUCING MOGROSIDES AND COMPOSITIONS COMPRISING SAME AND USES THEREOF - Isolated mogroside and mogrol biosynthetic pathway enzyme polypeptides useful in mogroside biosynthesis are provided. Mogroside biosynthetic pathway enzymes of the invention include squalene epoxidase (SE), expoxy hydratase (EH), cytochrome p450 (Cyp), cucurbitadienol synthase (CDS) and udp-glucosyl-transferase (UGT). Also provided are methods of producing a mogroside using the isolated mogroside and mogrol biosynthetic enzyme polypeptides, the methods comprising contacting a mogrol and/or a glycosylated mogrol (mogroside) with at least one UDP glucose glucosyl transferase (UGT) enzyme polypeptide of the invention catalyzing glucosylation of the mogrol and/or the glucosylated mogrol to produce a mogroside with an additional glucosyl moietie(s), thereby producing the mogroside. Alternatively or additionally provided is a method of synthesizing a mogrol, the method comprising contacting a mogrol precursor substrate with one or more mogrol biosynthetic pathway enzyme polypeptides as described herein catalyzing mogrol synthesis from the mogrol precursor substrate, thereby synthesizing the mogrol. | 2017-10-05 |
20170283845 | Systems and methods for multi-purpose analysis - Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample. | 2017-10-05 |
20170283846 | ARTICLES AND METHOD FOR DETECTING LISTERIA MONOCYTOGENES - A method of detecting | 2017-10-05 |
20170283847 | METHOD FOR RAPIDLY DETERMINING EFFECTIVE STERILIZATION , DEIMMUNIZATION, AND/OR DISINFECTION - A method for rapidly determining effective sterilization, deimmunization, and/or disinfection of equipment and/or supplies by a device. The method includes providing a defined surrogate protein having a predetermined sequence representative of an infectious agent potentially contaminating the equipment and/or the supplies to be sterilized, deimmunized, and/or disinfected by the device. The defined surrogate protein having the predetermined sequence is subjected to sterilization, deimmunization, or disinfection. The effectiveness of the sterilization deimmunization, or disinfection is rapidly determined by determining if the defined surrogate protein has been destroyed. | 2017-10-05 |
20170283848 | CHEMICAL INDICATING COMPOSITION, AUTOCLAVE PROCESS INDICATOR AND METHOD FOR PREPARING AUTOCLAVE PROCESS INDICATOR - A chemical indicating composition. The composition can include an aqueous resin in a form of polymer emulsion or polymer dispersion, the aqueous resin comprising a first aqueous resin composition and a second aqueous resin composition; a film-forming agent; a color changing composition; and water as a solvent. The chemical indicating composition of this disclosure can be used in an autoclave process indicator. | 2017-10-05 |
20170283849 | METHOD OF SAMPLING AND/OR DEPOSITING A SAMPLE OF BIOLOGICAL MATTER AND DEVICE IMPLEMENTING SUCH METHOD - The aim of the present invention is a method of sampling all or part of a sample ( | 2017-10-05 |
20170283850 | METHODS OF DETECTING ADENOSINE DEAMINASE DEFICIENCY - Disclosed are new approaches to detecting adenosine deaminase (ADA) deficiency. There is provided a method of determining ADA activity, comprising: dividing a sample obtained from blood into two portions, adding an ADA inhibitor to one portion, measuring levels of ADA activity in both portions, and determining the ADA activity. Also provided is a method of measuring ADA substrate, comprising: measuring an ADA substrate in a sample obtained from blood of subject, and comparing this to at least one control sample obtained from blood and comprising an ADA inhibitor, and a known quantity of the ADA substrate. Multiplexed methods of measuring ADA enzymatic activity along with other metabolic markers are also provided. The methods are particularly useful for the analysis of samples obtained from dried blood spots (DBSs), and may be incorporated into existing newborn screening programs. Associated diagnostic methods, control samples, and apparatuses are also disclosed. | 2017-10-05 |
20170283851 | Resonance Energy Transfer Assay with Cleavage Sequence and Spacer - Methods for the identification of inhibitors of botulinum neurotoxins are described. Cells are provided that are genetically engineered to express peptides that act as a substrate for a botulinum neurotoxin and the provide reporting groups. Spacer sequences between the reporting groups serve to optimize energy transfer between the reporting groups. Characterization of the energy transfer-dependent signal prior to and following exposure to a botulinum neurotoxin in the presence of a candidate inhibitor provides a measure of the effectiveness of the candidate inhibitor. | 2017-10-05 |
20170283852 | NOVEL UBIQUITINATION SYSTEM AND THE USES THEREOF - An unprecedented mechanism of ubiquitination that is independent of E1 and E2 enzymes, instead relying on activation of ubiquitin by ADP-ribosylation, and which is mediated by members of the SidE effector family encoded by the bacterial pathogen | 2017-10-05 |
20170283853 | REAGENT FOR PROTHROMBIN TIME MEASUREMENT, METHOD FOR PRODUCTION THEREOF, AND METHOD FOR MEASUREMENT OF PROTHROMBIN TIME - Disclosed is a reagent for prothrombin time measurement, containing a tissue factor and a surfactant, wherein the value of formula (I), which is represented by (surfactant amount (μmol))/(total protein amount (μg)), is 0.013 to 0.05 μmol/μg. | 2017-10-05 |
20170283854 | MULTIPLEXED PCR ASSAY FOR HIGH THROUGHPUT GENOTYPING - The present invention relates to identification and characterization of polymorphisms in a nucleic acid sample. Methods and compositions for the unbiased amplification of multiple target sequences within a nucleic acid sample are provided. | 2017-10-05 |
20170283855 | MICROFLUIDIC SIPHONING ARRAY FOR NUCLEIC ACID QUANTIFICATION - A microfluidic device can have a plurality of microchambers connected to a microchannel via siphon apertures. The microfluidic device may be formed from a thermoplastic and capped by a thermoplastic thin film. The microfluidic device may be used for digital polymerase chain reactions by forcing reagent into the microchambers at low pressure via an inlet, forcing any gas trapped in the microfluidic device to outgas through the thin film by applying high pressure to the microfluidic device via inlets and outlets of the microfluidic device, and applying air at low pressure to the inlets in order to digitize the chambers such that the reagent in each chamber is isolated from the reagent in other chambers by an air gap. After digitization, the device may be used to run a digital polymerase chain reaction process. | 2017-10-05 |
20170283856 | LYTIC COMPOSITION AND APPLICATION THEREOF, KIT, METHOD FOR PREPARING NUCLEIC ACID BY UTILIZING LYTIC COMPOSITION, AND NUCLEIC ACID ANALYSIS METHOD - The present invention relates to the technical field of biology, and in particular relates to a lytic composition and an application thereof, a kit, a method for preparing nucleic acid by utilizing the lytic composition, and a nucleic acid analysis method. A lytic product obtained in the present invention can be directly used for the nucleic acid analysis method without purifying the nucleic acid. According to the lytic composition disclosed by the present invention, multiple biological tissues and cells are lysed so as to release the nucleic acid of the cells into a solution, the nucleic acid in a whole-cell lysing and mixing state directly serves as a template without using a conventional nucleic acid separation and purification process after termination of the reaction, and nucleic acid amplification analysis is guided. For example, nucleic acid amplification is performed by a real-time fluorescence VCR, etc. | 2017-10-05 |
20170283857 | DETECTION OF NUCLEIC ACID SEQUENCES USING ENDONUCLEASE - Cloning vectors encoding endonuclease capable of removing false positives. Attempts to diagnose and/or select appropriate treatment methods via genetic screening can be rendered inaccurate do the presence of false positive. The error causing false positives may include double-stranded nucleic acids comprising a bulge and/or Y-junction. Expression vectors encoding an endonuclease capable of removing such error causing false positives are disclosed, along with methods of utilizing the encoded endonucleases to increase diagnostic accuracy and permit selection of more appropriate treatments. | 2017-10-05 |
20170283858 | Simple LAMP PCR Design For Low Resource Setting And Minimal Environmental Footprint - The present invention provides a device and method for testing a material for the presence of DNA. The system includes a centrifuge, a microchip performing cell lysis and an enclosure that contains an isothermal ballast material and chromogenic agent that melts at a specific temperature and displays a color change, respectively. | 2017-10-05 |
20170283859 | MICROFLUIDIC qRT-PCR ANALYSIS OF SINGLE CELLS - The disclosed subject matter provides a microdevice and techniques for single-cell gene expression profiling using a microfluidic device capable of cell-trapping, cell lysis, bead-based gene analysis. The microdevice can be capable of independent or parallelized, simultaneous quantitative genetic assays of single cells. | 2017-10-05 |
20170283860 | METHODS AND COMPOSITIONS FOR THE REMOVAL OF ALDEHYDE ADDUCTS AND CROSSLINKS FROM BIOMOLECULES - Methods are provided for reducing the number of aldehyde adducts and/or crosslinks from fixed biomolecules. In some cases, subject methods include contacting a sample having aldehyde fixed biomolecules (e.g., a biological sample such as a formalin fixed paraffin embedded (FFPE) tissue sample) with an adduct reversal agent in an amount and for a period of time sufficient to reduce the number of aldehyde fixation related adducts and/or crosslinks in the sample. In some cases, the adduct reversal agent is a compound that includes an aromatic ring and at least one of: an amine group and a proton-donating group. In some cases, the adduct reversal agent is a compound selected from the compounds of Table 1. Compositions and kits for practicing the subject methods are also provided. | 2017-10-05 |
20170283861 | METHOD AND REAGENTS FOR DETECTING WATER CONTAMINATION - A method of examining a water supply for microbial contamination involves contacting a water supply with a novel reagent having high specificity for a | 2017-10-05 |
20170283862 | GENETIC TESTING FOR PREDICTING RESISTANCE OF KLEBSIELLA SPECIES AGAINST ANTIMICROBIAL AGENTS - The invention relates to a method of determining an infection of a patient with | 2017-10-05 |
20170283863 | METHODS AND KITS FOR DETECTION OF 5-HYDROXYMETHYLCYTOSINE - The present invention relates to methods and kits for the detection of 5-hydroxymethylcytosine (5hmC). In some embodiments, the present invention relates to methods and kits for detection of 5hmC in nucleic acid (e.g., DNA, RNA). In some embodiments, the present invention relates to detection of 5hmC in genomic DNA, e.g., mammalian genomic DNA. | 2017-10-05 |
20170283864 | USE OF TRANSPOSASE AND Y ADAPTERS TO FRAGMENT AND TAG DNA - Described herein, among other things, is an adapter comprising a population of first oligonucleotides, a second oligonucleotide and a third oligonucleotide, wherein the first oligonucleotides, the second oligonucleotide and the third oligonucleotide are hybridized together to produce a complex that comprises: (i) a first end comprising a transposase recognition sequence, (ii) a central single-stranded region of variable sequence and (iii) a second end comprising sequences that are non-complementary. A method, as well as a kit for practicing the method, are also provided. | 2017-10-05 |
20170283865 | DNA DETECTION METHODS FOR SITE SPECIFIC NUCLEASE ACTIVITY - The present disclosure provides methods for detecting and identifying plant events that contain precision targeted genomic loci, and plants and plant cells comprising such targeted genomic loci. The method can be deployed as a high throughput process utilized for screening the intactness or disruption of a targeted genomic loci and optionally for detecting a donor DNA polynucleotide insertion at the targeted genomic loci. The methods are readily applicable for the identification of plant events produced via a targeting method which results from the use of a site specific nuclease. | 2017-10-05 |
20170283866 | NON-DESTRUCTIVE BILAYER MONITORING USING MEASUREMENT OF BILAYER RESPONSE TO ELECTRICAL STIMULUS - A method of detecting a lipid bilayer formed in a cell of a nanopore based sequencing chip is disclosed. An integrating capacitor is coupled with a lipid membrane, wherein the lipid membrane is between a working electrode and a counter electrode. An alternating current (AC) voltage is applied to the counter electrode. A voltage across the integrating capacitor is periodically sampled by an analog-to-digital converter (ADC). A change in the sampled voltage across the integrating capacitor in response to a change in the AC voltage is determined. Whether the lipid membrane comprises a lipid bilayer is detected based on the determined change in the sampled voltage across the integrating capacitor in response to the change in the AC voltage. | 2017-10-05 |
20170283867 | ELECTRICAL ENHANCEMENT OF BILAYER FORMATION - A method of forming a plurality of lipid bilayers over an array of cells in a nanopore based sequencing chip is disclosed. Each of the cells comprises a well. A salt buffer solution is flowed over the array of cells in the nanopore based sequencing chip to substantially fill the wells in the cells with the salt buffer solution. A lipid and solvent mixture is flowed over the array of cells to deposit the lipid and solvent mixture over at least some of the wells in the cells. A first portion of the cells, each having a lipid bilayer over its well, is detected. A second portion of the cells, each having a lipid membrane but not a lipid bilayer over its well, is detected. An electrical lipid-thinning stimulus is selectively applied to the second portion of the cells but not to the first portion of the cells. | 2017-10-05 |
20170283868 | METHODS AND APPARATUS FOR SINGLE MOLECULE SEQUENCING USING ENERGY TRANSFER DETECTION - Provided herein are systems and methods for nucleotide incorporation reactions. The systems comprise polymerases having altered nucleotide incorporation kinetics and are linked to an energy transfer donor moiety, and nucleotide molecules linked with at least one energy transfer acceptor moiety. The donor and acceptor moieties undergo energy transfer when the polymerase and nucleotide are proximal to each other during nucleotide binding and/or nucleotide incorporation. As the donor and acceptor moieties undergo energy transfer, they generate an energy transfer signal which can be associated with nucleotide binding or incorporation. Detecting a time sequence of the generated signals, or the change in the signals, can be used to determine the order of the incorporated nucleotides, and can therefore be used to deduce the sequence of the target molecule. | 2017-10-05 |
20170283869 | PREPARATION OF ADAPTER-LIGATED AMPLICONS - The present invention is directed to novel methods and kits to be employed for preparing adapter-ligated amplicons or a sequencing library of a target DNA, respectively. | 2017-10-05 |
20170283870 | METHODS FOR DETECTION OF NUCLEOTIDE MODIFICATION - This invention relates to improved methods and kits for identification of 5-formylcytosine (5fC) to be distinguished from cytosine (C) in a sample nucleotide sequence. Methods comprise reducing a first portion of polynucleotides which comprise the sample nucleotide sequence; treating the reduced first portion and a second portion of polynucleotides with bisulfite; sequencing the polynucleotides in the first and second portions of the population to produce first and second nucleotide sequences respectively and; identifying the residues in the first and second nucleotide sequences which correspond to a cytosine residue in the sample nucleotide sequence. These methods may be useful, for example in the analysis of genomic DNA and/or of RNA. | 2017-10-05 |
20170283871 | COMBINATION OF BIOMARKERS FOR DETECTING AND EVALUATING A HEPATIC FIBROSIS - The application concerns means for determining the stage of hepatic tissue damage, in particular the hepatic fibrosis score of subjects infected with one or more hepatitis viruses. In particular, the means of the invention involve measuring the levels of expression of selected genes, said selected genes being:
| 2017-10-05 |
20170283872 | COMPOSITIONS AND METHODS FOR ENHANCING ODORANT RECEPTOR ACTIVITY - The present invention relates to polypeptides capable of modulating odorant receptor activation. In particular, the present invention provides polypeptides (e.g., type 3 muscarinic actetylcholine receptor M3) capable of enhancing odorant receptor activation. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for polypeptide polymorphisms and mutations associated with odorant receptor activation (e.g., polymorphisms and mutations associated with muscarinic actetylcholine receptor polypeptides (e.g., M1, M2, M3, M4, M5)), as well as methods of screening for therapeutic agents, ligands, and modulators of such proteins. | 2017-10-05 |
20170283873 | SUPERVISED LEARNING METHODS FOR THE PREDICTION OF TUMOR RADIOSENSITIVITY TO PREOPERATIVE RADIOCHEMOTHERAPY - Disclosed is a gene expression panel that can predict radiation sensitivity (radiosensitivity) of a tumor in a subject. A method of predicting radiation sensitivity is provided that is based on cellular clonogenic survival after 2 Gy (SF2) for 48 cell lines. Gene expression is used as the basis of the prediction model. The radiosensitivity cell-based prediction model is validated using clinical patient data from rectal and esophagus cancer patients that received RT before surgery. The radiosensitivity genomic-based pre-diction model identifies patients with rectal cancer that may benefit from RT treatment by assigning higher values of SF2 to radio-resistant patients and lower values of SF2 to radio-sensitive patients. | 2017-10-05 |
20170283874 | Analytical Methods and Arrays for Use in the Same - The present invention relates to an in vitro method for identifying agents capable of inducing respiratory sensitization in a mammal and arrays and diagnostic kits for use in such methods. In particular, the methods include measurement of the expression of the biomarkers listed in Table 1A, Table 1B and/or Table 1C in MUTZ-3 cells exposed to a test agent. | 2017-10-05 |
20170283875 | BIOMARKER FOXF2 FOR GASTRIC CANCER - The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the FOXF2 gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating gastric cancer by increasing FOXF2 gene expression or activity. | 2017-10-05 |
20170283876 | BIOMARKER RNF6 FOR COLORECTAL CANCER - The present invention provides a method for diagnosing of colorectal cancer in a subject and a method for determining risk of recurrence of colorectal cancer among colorectal cancer patients by detecting overexpression of the RNF6 gene, which in some cases is due to a higher than normal copy number of the genomic sequence of this gene. A kit and device useful for such methods are also provided. In addition, the present invention provides a method for treating colon cancer by suppressing RNF6 gene expression or activity. | 2017-10-05 |
20170283877 | BIOMARKERS AND USES THEREOF IN PROGNOSIS AND TREATMENT STRATEGIES FOR RIGHT-SIDE COLON CANCER DISEASE AND LEFT-SIDE COLON CANCER DISEASE - Genetic biomarkers for left side colon cancer (LCC) (such as expression levels of an RNA transcript or expression product of NOX4, MMP3, or a combination) and right side colon cancer (RCC) (such as expression levels of an RNA transcript or expression product of CDCX2, FAM69A, or a combination), are disclosed. Methods for using the biomarkers in providing a prognosis of relapse-free survival probability in patients having LCC or RCC are also presented. Prognostic panels using gene expression values of the biomarkers are also presented. Computer implemented methods employing the biomarkers, and as well as for determining relapse-free survival probability in a patient having RCC or LCC are provided. A genetic method for classifying a colon cancer tissue as a RCC or as a LCC is also disclosed. | 2017-10-05 |
20170283878 | MODULATION OF GLOBOSERIES GLYCOSPHINGOLIPID SYNTHESIS AND CANCER BIOMARKERS - The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. Furthermore, the instant disclosure also relates to cancer stem cell biomarkers for diagnostic and therapeutic uses. | 2017-10-05 |
20170283879 | METHODS AND MATERIALS FOR ASSESSING HOMOLOGOUS RECOMBINATION DEFICIENCY - This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of homologous recombination deficiency (HRD) or an HRD signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an HRD signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided. | 2017-10-05 |
20170283880 | METHODS AND NUCLEIC ACIDS FOR ANALYSES OF COLORECTAL CELL PROLIFERATIVE DISORDERS - The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients. | 2017-10-05 |
20170283881 | EARLY LUNG CANCER DETECTION BY DNA METHYLATION PHENOTYPING OF SPUTUM-DERIVED CELLS - In certain embodiments, this application discloses methods for detecting lung cancer. The method includes characterization of cells extracted from human sputum, which is a valuable tissue surrogate and source of upper respiratory cells that become cancerous early in 5 the process of lung cancer development. The method includes the staining of extracted cells with fluorescent reporters that produce a specific pattern in the nuclei of labeled cells, which can be made visible by light microscopy. The pattern is relevant to a type of epigenetic coding of DNA known as DNA methylation, which changes in specific cells of the lung during cancer development, in comparison to normal respiratory cells. | 2017-10-05 |
20170283882 | METHODS AND THERAPEUTICS RELATING TO MRNA BIOMARKERS FOR CLINICAL PROGNOSIS OF CANCER - This disclosure provides methods and compositions of matter relating to the monitoring of relative concentrations of pairs of isoforms of mRNA or downstream expression products thereof. The methods can include measuring a relative expression level of a pair of mRNA isoforms or downstream expression products thereof and comparing the relative expression level to relative historical or cohort expression levels of the same pair of mRNA isoforms. The result of the comparison can lead to a more accurate prognosis for the subject. | 2017-10-05 |
20170283883 | METHODS FOR LUNG CANCER DETECTION - The disclosure describes a method for diagnosing lung cancer in a subject by detecting in a biological sample obtained from that patient a miRNA signature, the presence of which provides an earlier indication of cancer than alternative art-recognized methods, including, but not limited to, low-dose computed tomography (LDCT). | 2017-10-05 |
20170283884 | METHODS FOR PREDICTING DRUG RESPONSIVENESS - The present invention provides drug response predictors and biomarkers useful for assessing the responsiveness of a subject to treatment with one or more target drugs of interest, such as 5-fluorouracil (5-FU), irinotecan, and/or oxaliplatin. In particular, the invention provides methods useful in determining whether a subject is sensitive or resistant to a target drug by, e.g., measuring the expression level of one or more biomarkers of sensitivity and/or resistance to the drug in a biological sample obtained from the subject. The invention further features devices and kits for assessing target drug responsiveness in a subject, for example, by determining the expression level of such biomarkers. | 2017-10-05 |
20170283885 | ALGORITHMS FOR GENE SIGNATURE-BASED PREDICTOR OF SENSITIVITY TO MDM2 INHIBITORS - Provided are gene signatures that are predictive of the sensitivity of a cancer or tumor to an MDM2i or an antagonist of the MDM2-p53 interaction. Differentially expressed genes in the provided gene signatures serve as biomarkers for determining and assessing the sensitivity of cancer and tumor samples to treatment or therapy with an MDM2i. Also provided are methods of determining MDM2i sensitivity of a test sample such as different cancer and tumor types and subtypes, based on the expression of genes in the MDM2i sensitive gene signatures in reference samples and the test sample even if all of the MDM2i sensitivities of the reference samples are unknown, and treating individuals with an MDM2i if their cancers are determined to be MDM2i-sensitive, based on the practice of the described methods. TP53 gene and p53 protein status can also be determined for the samples undergoing analysis for MDM2i sensitivity. | 2017-10-05 |
20170283886 | Methods for Diagnosis, Prognosis and Monitoring of Breast Cancer and Reagents Therefor - The present disclosure provides methods and reagents for the diagnosis, prognosis or the monitoring of breast cancer, including various subtypes of breast cancer including, for example, estrogen receptor (ER) negative breast cancer, ER positive breast cancer, triple negative breast cancer (TNBC) and other subtypes of breast cancer. | 2017-10-05 |
20170283887 | DIAGNOSIS OF LUNG CANCER - The present invention relates to specifically methylated nucleic acids, methods of diagnosing lung cancer or a predisposition therefor, and a corresponding kit. | 2017-10-05 |
20170283888 | USE OF RNASE H FOR THE SELECTIVE AMPLIFICATION OF VIRAL DNA - The present invention concerns the amplification of at least a first and a second target nucleic acid that may be present in at least one fluid sample using RNase H and a polymerase with reverse transcriptase activity. | 2017-10-05 |
20170283889 | Biomarkers for HBV treatment response - The present invention relates to methods that are useful for predicting the response of hepatitis B virus (HBV) infected patients to pharmacological treatment. | 2017-10-05 |
20170283890 | Mutant Bordetella Strains and Methods of Use - A method of reducing or preventing the development of airway inflammation in a subject includes the step of infecting the respiratory tract of a subject an amount of a composition including a pharmaceutically acceptable carrier and live attenuated pertactin-deficient | 2017-10-05 |
20170283891 | METHOD FOR DETECTING AIR FLOW DISTRIBUTION IN BLAST FURNACE - A method for detecting an air flow distribution in a blast furnace, taking into account a heat exchange between an air flow and a solid material bed and the effect of a distribution of a material layer structure in a radial direction of a blast furnace on the radial air permeability of blast furnace, which affects a mode of air flow distribution, wherein the distribution of the air flow and the radial material layer structure of the blast furnace can be calculated by combining a cross-shaped temperature-measuring gun and other main blast furnace operating parameters. According to the detection method, a blast furnace operator can timely and accurately infer, from a change in a current radial air flow temperature distribution, the direction of change of the distribution of the air flow and the radial material layer structure at a furnace throat portion. | 2017-10-05 |
20170283892 | METHOD FOR LASER BEAM HEAT TREATMENT OF PRESS HARDENED COMPONENTS AND PRESS HARDENED COMPONENTS - Methods for manufacturing hot-stamped components are described. The method includes providing a hot-stamped component by hot forming die quenching, and selecting a first and a second portion of the hot-stamped component, wherein the first portion has a different width than the second portion. A laser system, wherein the laser system c includes one or more optical elements and a laser source for generating a laser beam. The laser system is moved along a length of the component. Finally, the laser beam is applied in a single pass onto the selected first and second portions using the laser system, wherein a laser beam spot size is adjusted during the application of the laser beam and is adapted to the widths of the first and second portions, and wherein a power of the laser beam is regulated based on the temperature measured in the hot-stamped component. The disclosure further relates to components obtained using such methods. | 2017-10-05 |
20170283893 | Solid State Grain Alignment Of Permanent Magets in Near-Final Shape - Magnet microstructure manipulation in the solid state by controlled application of a sufficient stress in a direction during high temperature annealing in a single-phase region of heat-treatable magnet alloys, e.g., alnico-type magnets is followed by magnetic annealing and draw annealing to improve coercivity and saturation magnetization properties. The solid-state process can be termed highly controlled abnormal grain growth (hereafter AGG) and will make aligned sintered anisotropic magnets that meet or exceed the magnetic properties of cast versions of the same alloy types. | 2017-10-05 |
20170283894 | FERRITIC STAINLESS STEEL HAVING EXCELLENT DUCTILITY AND METHOD FOR MANUFACTURING SAME - Ferritic stainless steel having a high degree of ductility and a method for manufacturing the ferritic stainless steel are provided. The stainless steel includes, by wt %, C: 0.005% to 0.1%, Si: 0.01% to 2.0%, Mn: 0.01% to 1.5%, P: 0.05% or less, S: 0.005% or less, Cr: 10% to 30%, Ti: 0.005% to 0.5%, Al: 0.01% to 0.15%, N: 0.005% to 0.03%, and the balance of Fe and inevitable impurities, wherein the ferritic stainless steel includes 3.5×10 | 2017-10-05 |
20170283895 | RAIL MANUFACTURING METHOD AND RAIL MANUFACTURING APPARATUS - A method and an apparatus for manufacturing a rail having high ductility in both a head portion and a foot portion. A heated steel rail material is hot-rolled, the temperature is adjusted by cooling the hot-rolled steel rail material, the steel rail material subjected to the temperature adjustment is processed into a rail shape by means of temperature-adjusted rolling at an area reduction ratio of 20% or more, and, in adjusting the temperature of the steel rail material, the surface portions of the steel rail material corresponding to a head portion and a foot portion of the rail shape so that the temperatures of the surface portions reach 500° C. or more and 1,000° C. or less. | 2017-10-05 |
20170283896 | LOW-TEMPERATURE HIGH-STRENGTH-AND-DUCTILITY HIGH MANGANESE STEEL, AND HIGH MANGANESE STEEL PLATE AND HIGH MANGANESE STEEL TUBE MANUFACTURING PROCESS - The present invention discloses a machining technology of a low-temperature high-strength-ductility high manganese steel, high manganese steel plate, and high manganese steel tube, and a high manganese steel comprises the following components in percentage by weight: Mn 30%-36%, C 0.02%-0.06%, S≦0.01%, P≦0.008% and the balance being Fe. Smelted steel ingots are subject to solution treatment and are rolled and homogenized to obtain a high manganese steel plate or are drawn to form a high manganese steel tube. The hot-rolled or cold-rolled steel plate after being hot-rolled has tremendous application value in the fields of low-temperature applications, such as the steel plate used for a low temperature pressure container. | 2017-10-05 |
20170283897 | METHOD AND SYSTEM FOR THE PRODUCTION OF A SEAMLESS HOT-ROLLED TUBE AS WELL AS A ROLLED CENTRIFUGALLY CAST TUBE AND USE OF A HOLLOW BLOCK PRODUCED BY MEANS OF CENTRIFUGAL CASTING - Sensitive hollow blocks or tubes are elongated in a hot-forming elongator while maintaining, if possible, the internal structure that is present or that forms immediately after casting, and thereby, in the case of suitable method management, even thin-walled tubes or tubes rolled from centrifugally cast hollow blocks can be made available to a sufficiently operationally reliable extent. As a result, for the first time, it is possible for rolled centrifugally cast composite material tubes to be made available and for composite material hollow. blocks produced using centrifugal casting to be utilized for the production of a seamless tube. | 2017-10-05 |
20170283898 | APPARATUS AND METHOD FOR QUENCHING RODS AND TUBES - The present invention relates to a apparatus for statically quenching a product ( | 2017-10-05 |
20170283899 | CARBURIZING AUSTEMPERING PROCESS - A novel combination of heat treatment steps includes the steps of carburizing a component fabricated of a medium carbon alloy steel at an elevated temperature for between three and six hours, subjecting the component to an austempering bath and holding it there for between fifteen and two hundred forty minutes and finally cooling the component to room temperature to allow martensitic transformation. These steps may be followed with cryogenic treatment to reduce retained austenite if needed. The process produces components with low distortion, high surface hardness, from HRC 56 to 62, and high surface compressive residual stress. | 2017-10-05 |
20170283900 | HIGH-STRENGTH HOT-DIP GALVANIZED STEEL SHEET AND METHOD FOR MANUFACTURING THE SAME (AS AMENDED) - A high-strength hot-dip galvanized steel sheet and a method for manufacturing the steel sheet are provided. The high-strength hot-dip galvanized steel sheet has a specific composition including C, Si, Mn, etc. In this chemical composition, the content of Ti [Ti] and the content of N [N] satisfy [Ti]>4[N]. The high-strength hot-dip galvanized steel sheet has a microstructure including martensite at an area fraction of 60% or more and 90% or less, polygonal ferrite at an area fraction of more than 5% and 40% or less, and retained austenite at an area fraction of less than 3% (including 0%). The average hardness of the martensite is 450 or more and 600 or less in terms of Vickers hardness, and the average crystal grain diameter of the martensite is 10 μm or less. The standard deviation of the crystal grain diameters of the martensite is 4.0 μm or less. | 2017-10-05 |
20170283901 | GRADE 550MPA HIGH-TEMPERATURE RESISTANT PIPELINE STEEL AND METHOD OF MANUFACTURING SAME - Disclosed is a Grade 550 MPa high temperature-resistant pipeline steel, the chemical elements, in mass percentage, being: 0.061%≦C≦0.120%, 1.70%≦Mn≦2.20%, 0.15%≦Mo≦0.39%, 0.15%≦Cu≦0.30%, 0.15%≦Ni≦0.50%, 0.035%≦Nb≦0.080%, 0.005%≦V≦0.054%, 0.005%≦Ti≦0.030%, 0.015%≦Al≦0.040%, 0.005%≦Ca≦0.035%, and the balance being Fe and unavoidable impurities. Also disclosed is a manufacturing method of the Grade 550 MPa high temperature-resistant pipeline steel, comprising the steps of: smelting, casting, slab heating, rough rolling, finish rolling, controlled cooling, and air cooling to room temperature. The pipeline steel has an excellent mechanical property under a high temperature. | 2017-10-05 |
20170283902 | HOT DIP GALVANIZED AND GALVANNEALED STEEL SHEET HAVING EXCELLENT ELONGATION PROPERTIES - There is provided a hot-dip galvanized steel sheet and a hot-dip galvannealed steel sheet, which have excellent elongation properties, and methods for manufacturing the hot-dip galvanized steel sheet and the hot-dip galvannealed steel sheet. The present disclosure relates to a hot-dip galvanized steel sheet in which a hot-dip galvanized layer is formed on a surface of abase steel sheet, the hot-dip galvanized steel sheet having excellent elongation properties and being characterized by the composition and the microstructure thereof. | 2017-10-05 |
20170283903 | Process for producing grain-oriented electrical steel strip and grain-oriented electrical steel strip obtained according to said process - A process for producing grain-oriented electrical steel strip by means of thin slab continuous casting, comprising the following process steps: a) smelting a steel, b) continuously casting the smelt by thin slab continuous casting, c) heating up the thin slabs and subjecting the slabs to homogenization annealing at a maximum temperature of 1250° C., d) heating to a temperature between 1250° C. and 1350° C., e) continuously hot rolling the thin slabs to form a hot-rolled strip, f) cooling and reeling the hot-rolled strip to form a coil, g) annealing the hot-rolled strip after reeling and prior to a subsequent cold rolling step, h) cold rolling the hot-rolled strip to the nominal usable thickness, i) subjecting the cold-rolled strip to recrystallization, decarburization and nitridation annealing, j) applying an annealing separator (non-stick layer) to the strip surface of the cold-rolled strip, k) subjecting the cold-rolled strip to secondary recrystallization annealing, forming a finished steel strip having a pronounced Goss texture, and l) stress-free annealing the finished steel strip, which has been coated with an insulating layer, provides an improved process for producing grain-oriented electrical steel strip by means of thin slab continuous casting. This is achieved in that the recrystallization, decarburization and nitridation annealing of the cold-rolled strip in process step h) comprises a decarburization annealing phase and a subsequent nitridation annealing phase, with an intermediate reduction annealing phase being interposed between the decarburization annealing phase and the nitridation annealing phase, and carried out at a temperature ranging from 820° C.-890° C., for a maximum period of 40 seconds, with a dry, gaseous annealing atmosphere, which contains nitrogen (N | 2017-10-05 |
20170283904 | METHOD FOR PRODUCING COLD-FORMED STEEL SPRINGS - A process for producing a spring and/or torsion bar from a steel wire by cold forming may involve providing a steel wire; thermomechanically forming the steel wire above a minimum recrystallization temperature of the steel wire; cooling the steel wire; tempering the steel wire, which may involve heating, quenching, reheating, and cooling the steel wire; cold forming the steel wire at a cold forming temperature, the cold forming temperature being a temperature below the minimum recrystallization temperature of the steel wire; and separating the steel wire. With respect to the cooling of the steel wire, the steel wire may be cooled to a temperature below the minimum recrystallization temperature such that at least a partly ferritic-pearlitic structure is formed in the steel wire. | 2017-10-05 |
20170283905 | METHOD FOR PRODUCING GRANULAR METALLIC IRON - A method for producing granular metallic iron of the present invention includes: an agglomeration step of obtaining agglomerates through agglomeration of a mixture that contains an iron oxide-containing material and a carbonaceous reducing agent; and a granulation step of obtaining granular metallic iron by heating the agglomerates, reducing iron oxides in the agglomerates, aggregating generated metallic iron to be granular while separating the metallic iron from slag generated as a by-product, and thereafter cooling and solidifying the metallic iron, wherein agglomerates satisfying all the conditions given by formulas (1) to (3) below are used as the agglomerates: (1) [(total CaO amount+total SiO | 2017-10-05 |
20170283906 | METHOD FOR DEOXIDIZING Ti-Al ALLOY - A method for deoxidizing a Ti—Al alloy includes melting and holding a Ti—Al alloy containing 40 mass % or more of Al by a melting method using a water-cooled copper vessel in an atmosphere of 1.33 Pa or more, thereby decreasing an oxygen content in the Ti—Al alloy. The Ti—Al alloy is manufactured using an alloy material composed of a titanium material and an aluminum material. The alloy material contains oxygen in a total amount of 0.1 mass % or more. | 2017-10-05 |
20170283907 | FUMING FURNACE WITH LEAD COLLECTING AND DISCHARGING FUNCTION - Disclosed is a fuming furnace with a lead collecting and discharging function, the fuming furnace comprising a furnace body; the furnace body is provided with a hearth therein and a tuyere thereon; the bottom of the hearth forms a molten pool; the furnace body is further provided with a slag discharging outlet and a lead discharging outlet thereon; the furnace body comprises a furnace bottom water jacket and a hearth water jacket; the furnace bottom water jacket is provided with a refractory brick layer at the inner wall thereof; the refractory brick layer is provided with a lead collecting and discharging channel therein for collecting and discharging lead; the lead collecting and discharging channel is in communication with the lead discharging outlet, and the lead collecting and discharging channel is in communication with the molten pool via joints between the refractory bricks forming the refractory brick layer. | 2017-10-05 |
20170283908 | SYSTEM AND METHOD FOR ENHANCED METAL RECOVERY DURING ATMOSPHERIC LEACHING OF METAL SULFIDES - A method of improving metal leach kinetics and recovery during atmospheric or substantially atmospheric leaching of a metal sulfide is disclosed. In some embodiments, the method may comprise the steps of: (a) producing a metal sulfide flotation concentrate; (b) processing the metal sulfide concentrate in a reductive activation circuit that operates at a first redox potential, to produce a reductively-activated metal sulfide concentrate; and, (c) subsequently processing the activated metal sulfide concentrate in an oxidative leach circuit to extract metal values. In some disclosed embodiments, reductive activation steps may be employed prior to oxidative leaching steps (including heap leap leaching or bio-leaching steps). In some embodiments, physico-chemical processing steps may be employed during reductive activation and/or oxidative leaching. Systems for practicing the aforementioned methods are also disclosed. | 2017-10-05 |
20170283909 | TITANIUM-BASED COMPOSITIONS, METHODS OF MANUFACTURE AND USES THEREOF - Titanium-based compositions as well as titanium composites such as carbide-reinforced titanium composites are disclosed herein. More specifically, composite materials comprising a titanium metal matrix and titanium carbide dispersed in the matrix are disclosed. The composite materials comprise about 0.5 wt. % to about 3.0 wt. % of carbon, based on the total weight of titanium and carbon in the composite materials. Compositions comprising a titanium-based powder and at least one of a carbon-based material and a binder are also disclosed. The compositions comprise about 0.5 wt. % to about 3.0 wt. % of carbon-based material, based on the total weight of the titanium-based powder and the carbon-based material. | 2017-10-05 |
20170283910 | CONDUCTIVE MATERIAL FOR CONNECTION PARTS WHICH HAS EXCELLENT MINUTE SLIDE WEAR RESISTANCE - A conductive material for connection parts includes a matrix, a Cu—Sn alloy covering layer having a Cu content of 20 to 70 at % and an average thickness of from 0.2 to 3.0 μm, and a Sn covering layer having an average thickness of from 0.05 to 5.0 μm. The matrix is a copper alloy strip containing specified amounts of Cr and Zr or specified amounts of Fe and P, or a Cu—Zn alloy strip containing a specified amount of Zn. The Cu—Sn alloy covering layer and the Sn covering layer are formed in this order on a surface of the matrix. | 2017-10-05 |
20170283911 | Cu-BASED SINTERED BEARING AND PRODUCTION METHOD FOR Cu-BASED SINTERED BEARING - Provided is a Cu-based sintered bearing comprising: 15-36 mass % of Ni; 3-13 mass % of Sn; 0.05-0.55 mass % of P; and 0.02-4 mass % of C in total, the balance consisting of Cu and inevitable impurities, wherein the content of C forming an alloy with a matrix within Cu—Ni-based main phase grains is 0.02-0.10 mass %. | 2017-10-05 |
20170283912 | TITANIUM SINTERED BODY, ORNAMENT, AND HEAT RESISTANT COMPONENT - A titanium sintered body is composed of a material containing titanium, and has an oxygen content of 2500 ppm by mass or more and 5500 ppm by mass or less and a surface Vickers hardness of 250 or more and 500 or less. It is preferred that an α-phase and a β-phase are contained as crystal structures, and an area ratio occupied by the α-phase in a cross section is 70% or more and 99.8% or less. It is also preferred that in an X-ray diffraction spectrum obtained by X-ray diffractometry, the value of a peak reflection intensity by the plane orientation (110) of the β-phase is 5% or more and 60% or less of the value of a peak reflection intensity by the plane orientation (100) of the α-phase. It is also preferred that particles composed mainly of titanium oxide are included. | 2017-10-05 |
20170283913 | ALUMINUM ALLOY SHEET HAVING HIGH FORMABILITY - Provided is a 6xxx-series aluminum sheet having high formability for automotive body panel use, which can be produced without significant changes in conventional chemical compositions and production conditions. The 6xxx-series aluminum alloy sheet is controlled in its microstructure as follows. The average grain size of the microstructure is controlled to be small; and the average proportion of small angle grain boundaries after application of tensile deformation to the sheet is controlled at two levels in a low strain region and a high strain region according to the levels of strain imparted by the tensile deformation. This restrains heterogeneous deformation from the high strain region leading to rupture upon press forming into an automotive body panel, and allows the sheet to offer good work hardening properties and to have high formability. | 2017-10-05 |
20170283914 | WROUGHT ALUMINUM ALLOY - Provided is a wrought aluminum alloy including 5.5 to 6.0 wt % of Zn, 2.0 to 2.5 wt % of Mg, 0.2 to 0.6 wt % of Cu, 0.1 to 0.2 wt % of Cr, at most 0.2 wt % (and more than 0 wt %) of Fe, at most 0.2 wt % (and more than 0 wt %) of Mn, at most 0.2 wt % (and more than 0 wt %) of Si, at most 0.1 wt % (and more than 0 wt %) of Ti, and at most 0.05 wt % (and more than 0 wt %) of Sr, with the remainder being Al. | 2017-10-05 |
20170283915 | MAGNESIUM ALLOY, MAGNESIUM ALLOY SHEET, MAGNESIUM ALLOY STRUCTURAL MEMBER, AND METHOD FOR PRODUCING MAGNESIUM ALLOY - A magnesium alloy contains, in mass %, from 1% to 12% inclusive of Al and from 0.1% to 5% inclusive of Mn and has a structure in which particles of compounds containing Al and Mn are dispersed. The average diameter of the particles of the compounds is from 0.3 μm to 1 μm inclusive, and the area ratio of the particles of the compounds is from 3.5% to 25% inclusive. | 2017-10-05 |
20170283916 | Ta-Nb ALLOY POWDER AND ANODE ELEMENT FOR SOLID ELECTROLYTIC CAPACITOR - A Ta-Nb alloy powder which has provides a capacitor having a higher capacitance than a Ta capacitor and a better thermal stability in terms of an oxide film is better than a Nb capacitor, the Ta-Nb alloy powder being a Ta-Nb alloy powder produced by a thermal CVD method, wherein a content of Nb is 1 to 50 mass %, and an average particle diameter of primary particles is 30 to 200 nm, preferably, a CV value per unit mass of the powder (μF·V/g) is 250 kμF·V/g or more, or further, a CV value per unit volume (μF·V/mm | 2017-10-05 |
20170283917 | MANUFACTURING METHOD OF AUSTENITIC STAINLESS STEEL - A method of manufacturing an austenitic stainless steel, being dissolved and refined, by providing Si from 0.2 to 2.0% by mass, Mn from 0.3 to 5.0% by mass, S at 0.007% by mass or less, Ni from 7.0 to 15.0% by mass, Cr from 15.0 to 20.0% by mass, Al at 0.005% by mass or less, Ca at 0.002% by mass or less, Mg at 0.001% by mass or less, and 0 from 0.002 to 0.0065% by mass and setting a ratio, during refining, of CaO/SiO | 2017-10-05 |
20170283918 | HIGH-STRENGTH SEAMLESS STEEL PIPE FOR OIL COUNTRY TUBULAR GOODS AND METHOD OF PRODUCING THE SAME - Provided is a high-strength seamless steel pipe having the composition which contains, by mass %, 0.20 to 0.50% C, 0.05 to 0.40% Si, 0.3 to 0.9% Mn, 0.015% or less P, 0.005% or less S, 0.005 to 0.1% Al, 0.008% or less N, more than 0.6% and 1.7% or less Cr, more than 1.0% and 3.0% or less Mo, 0.01 to 0.30% V, 0.001% or more and less than 0.01% Nb, 0.0003 to 0.0030% B, and 0.0030% or less O (oxygen). The high-strength seamless steel pipe has the microstructure where a volume fraction of a tempered martensitic phase is 95% or more, and prior austenitic grains have a grain size number of 8.5 or more, and a segregation degree index Ps which is defined by a formula Ps=8.1 (X | 2017-10-05 |