40th week of 2016 patent applcation highlights part 30 |
Patent application number | Title | Published |
20160289618 | COMPOSITION FOR FILTERING AND REMOVING PARTICLES AND/OR CONSTITUENTS FROM A FLUID - Filter-aid materials are disclosed herein, and processes, systems, and methods using such filter-aid materials for filtering and removing particles and/or constituents from a fluid, wherein the filter-aid material comprises at least one filterable composite adsorbent comprising at least one adsorbent component formed in-situ on at least one filtration component. Further disclosed herein are filter-aid materials and processes, systems, and methods using such filter-aid materials for filtering and removing particles and/or constituents from a fluid, wherein the filter-aid material comprises at least one filterable composite adsorbent comprising at least one adsorbent component formed in-situ on at least one filtration component, and wherein the filter-aid material further comprises an at least one additional filtration component mixed with the at least one filterable composite adsorbent. | 2016-10-06 |
20160289619 | Aging of Alcoholic Beverages Using Controlled Mechanically Induced Cavitation - An extreme acceleration of the process of aging spirits to obtain aged liquors includes circulating the spirits through a cavitation zone within a controlled cavitation reactor and exposing the spirits therein to high energy cavitation induced shockwaves. Sources of flavor and color such as charred wood chips may be added to the spirits to provide the color and flavor of liquors aged for years in traditional charred oak barrels. The method and apparatus of the present invention obtains the same conversion of undesirable alcohols, flavor extraction, and color as years of aging in an oak barrel but does so in a matter of minutes or hours. The apparatus and method also can be used in conjunction with traditional aging techniques and methods and the total aging time is still reduced dramatically. | 2016-10-06 |
20160289620 | Flexible Bioreactor and Support Structure System - Some embodiments include a system having a support structure configured to mechanically support a first bioreactor. The support structure can have a first frame and a second frame together being configured to mechanically support the first bioreactor in interposition between the first frame and the second frame. The first frame can maintain a first set point temperature of the first bioreactor through an exchange of thermal energy between the first frame and the first bioreactor when the first bioreactor is vitally supporting one or more first microorganisms and when the support structure is mechanically supporting the first bioreactor. Other embodiments of related systems and methods are also disclosed. | 2016-10-06 |
20160289621 | METHOD OF ASSEMBLING A FLEXIBLE BIOREACTOR - Some embodiments include a method. The method can include: providing one or more bioreactor walls of a bioreactor, the one or more bioreactor walls having at least one bioreactor wall material; providing one or more bioreactor fittings of the bioreactor, the one or more bioreactor fittings having at least one gas delivery fitting; providing one or more gas delivery devices of the bioreactor; providing one or more flexible tubes of the bioreactor, the one or more flexible tubes having at least one gas delivery tube; providing at least one parameter sensing device; and assembling the bioreactor. Other embodiments of related systems and methods are also disclosed. | 2016-10-06 |
20160289622 | AGITATING DEVICE FOR A DIGESTER OF A BIOGAS PLANT AND METHOD FOR MANUFACTURING AN AGITATING DEVICE | 2016-10-06 |
20160289623 | Cell Culture Array System For Automated Assays And Methods Of Operation And Manufacture - A number of novel improved microfluidic configurations and systems and methods of manufacture and operation. In one embodiment, three wells are used for independent cell culture systems in a cell culture array. In a second aspect, artificial sinusoids with artificial epithelial barriers are provided with just one (optionally shared or multiplexed) fluidic inlet and one (optionally shared or multiplexed) fluidic output, where the medium output also functions as a cellular input. A pneumatic cell loader combined with other components provides a fully automated cell culture system. Magnetic alignment of plate molds provides advantages and ease of molded manufacture. | 2016-10-06 |
20160289624 | CULTURE CONTAINER, METHOD FOR CULTURING LYMPHOCYTES, CULTURE-CONTAINER PRODUCTION METHOD, AND SOLID-PHASING APPARATUS - A culture container for culturing lymphocytes includes an immobilized surface and a non-immobilized surface, wherein the culture container is formed of a gas permeable film, the immobilized surface and the non-immobilized surface are container inner surfaces facing each other, and anti-CD3 antibodies are immobilized in the immobilized surface at a concentration of 10 to 300 ng/cm | 2016-10-06 |
20160289625 | SYSTEM FOR VITALLY SUPPORTING ORGANISMS AND METHODS OF PROVIDING AND USING THE SAME - Some embodiments include a system comprising a bioreactor operable to vitally support one or more microorganisms. The bioreactor includes a bioreactor cavity configured to contain the microorganism(s) and a fluidic support medium, one or more bioreactor walls at least partially enclosing the bioreactor cavity and having at least one bioreactor wall material, one or more bioreactor fittings, one or more gas delivery devices, and one or more flexible tubes. The at least one bioreactor wall material can be flexible, the bioreactor can be be autoclaved one or more times to sterilize the bioreactor, and the bioreactor is can be gathered up by at least one of folding or rolling up the bioreactor. Other embodiments of related systems and methods are also disclosed. | 2016-10-06 |
20160289626 | MICRO-TITRE PLATE WITH CAPILLARY MEMBRANE SUPPLY UNIT - An apparatus for growing and/or examining cells, comprising the arrangement of at least one bowl-shaped culture dish having a base and a side wall, and an interior which is bounded by the base and side wall and has an opening at the top end, characterized in that—at least one sheet-like capillary membrane system composed of at least one capillary membrane is disposed in the interior of the culture dish,—wherein the at least one capillary membrane has a semipermeable wall, a lumen which is enclosed by the wall and has at least one open end and has a fluid connection via its open end to a supply line having a wall and a lumen, such that liquids, media, gases and/or other substances can be passed through the supply line and the capillary membrane system,—wherein the capillary membrane system is disposed in the region of the base of the respective culture dish and its areal extent is limited by the side wall of the culture dish and—wherein the at least one supply line leads out of the interior through the opening. | 2016-10-06 |
20160289627 | APPARATUS FOR BUILDING COMPLEX 3D BIOMIMETIC SCAFFOLDS - A system and apparatus for constructing complex three-dimensional scaffolds that takes advantage of the physical and chemical properties of gelatin-sugar hydrogels. Novel apparatus for building complex three-dimensional scaffolds for biomimetic applications such as in vitro organ growth, using a gelatin/sugar/water gel, ultraviolet radiation, and heat or enzyme are described. The apparatus produce gelatin-sugar hydrogels demonstrating greater thermal stability, mechanical strength, and resistance to enzymatic degradation. The invention also provides a means to assemble the gelatin sugar hydrogel films into complex three-dimensional structures (scaffolds). To account for the native biochemical factors present in natural scaffolds, methods of conjugating such factors to the gelatin-sugar hydrogel are described. These scaffolds can then be applied for tissue culturing and organ growth. | 2016-10-06 |
20160289628 | METHOD OF MIXOTROPHIC CULTURING OF MICROALGAE IN A FLEXIBLE BIOREACTOR - Some embodiments include a method of culturing one or more microalgae. The method can include: inoculating a bioreactor with the one or more microalgae and a fluidic support medium, the bioreactor having one or more bioreactor walls at least partially enclosing a bioreactor cavity, being configured to be at least one of folded up or rolled up, and being sterile when the bioreactor is inoculated with the one or more microalgae, the one or more bioreactor walls comprising at least one bioreactor wall material, and the at least one bioreactor wall material being flexible and at least partially transparent; and vitally supporting the one or more microalgae. Other embodiments of related systems and methods are also disclosed. | 2016-10-06 |
20160289629 | METHOD OF VITALLY SUPPORTING MICROALGAE IN A FLEXIBLE BIOREACTOR - Some embodiments include a method. The method can include: inoculating a bioreactor with one or more first microorganisms and a first fluidic support medium, the bioreactor having one or more bioreactor walls at least partially enclosing a bioreactor cavity, being configured to be at least one of folded up or rolled up, and being sterile when the bioreactor is inoculated with the one or more first microorganisms, the one or more bioreactor walls having at least one bioreactor wall material, and the at least one bioreactor wall material being flexible and at least partially transparent; and vitally supporting the one or more first microorganisms with the bioreactor, a supply of light, and a supply of organic carbon. Other embodiments of related systems and methods are also disclosed. | 2016-10-06 |
20160289630 | BIOREACTOR STERILIZATION METHOD FOR MULTIPLE USES - Some embodiments include a method. The method can include: conducting a first sterilization of an assembled bioreactor; after conducting the first sterilization of the assembled bioreactor, vitally supporting one or more first microorganisms with the assembled bioreactor; after vitally supporting the one or more first microorganisms with the assembled bioreactor, removing the one or more first microorganisms from the assembled bioreactor; after removing the one or more first microorganisms from the assembled bioreactor, gathering up the assembled bioreactor; after gathering up the assembled bioreactor, conducting a second sterilization of the assembled bioreactor; and after conducting the second sterilization of the assembled bioreactor, vitally supporting one or more second microorganisms with the assembled bioreactor. Other embodiments of related systems and methods are also disclosed. | 2016-10-06 |
20160289631 | FLEXIBLE BIOREACTOR AND SUPPORT STRUCTURE METHOD - Some embodiments include a method. The method includes: providing a support structure; and providing a bioreactor operable to vitally support one or more microorganisms. The bioreactor includes a bioreactor cavity configured to contain the one or more microorganisms and a fluidic support medium and one or more bioreactor walls at least partially enclosing the bioreactor cavity. The bioreactor wall(s) have at least one bioreactor wall material that is flexible. The support structure is operable to mechanically support the bioreactor. Other embodiments of related systems and methods are also disclosed. | 2016-10-06 |
20160289632 | Hyperblebbing Shigella Strains - Hyperblebbing | 2016-10-06 |
20160289633 | Use of Perfusion Seed Cultures to Improve Biopharmaceutical Fed-Batch Production Capacity and Product Quality - Methods of improving the efficiency of production of a protein product of interest in mammalian cell culture are presented. In particular, the methods result in an increase in the quantity of a protein product produced, or decreases protein product production time in a manufacturing-scale bioreactor cell culture. The disclosed methods comprise: (a) culturing the N-1 bioreactor culture to high viable cell densities; and (b) seeding the production bioreactor culture at high viable cell seeding densities. | 2016-10-06 |
20160289634 | METHOD OF COLLECTING PLACENTAL STEM CELLS - A method of collecting embryonic-like stem cells from a placenta which has been treated to remove residual cord blood by perfusing the drained placenta with an anticoagulant solution to flush out residual cells, collecting the residual cells and perfusion liquid from the drained placenta, and separating the embryonic-like cells from the residual cells and perfusion liquid. Exogenous cells can be propagated in the placental bioreactor and bioactive molecules collected therefrom. | 2016-10-06 |
20160289635 | METHOD FOR MANUFACTURING TELENCEPHALON OR PROGENITOR TISSUE THEREOF - The present invention provides a method of producing more mature telencephalon or a progenitor tissue thereof, in vitro, from mammalian pluripotent stem cells, comprising obtaining a telencephalon marker-positive aggregate by culturing an aggregate of pluripotent stem cells in suspension in the presence of a Wnt signal inhibitor and a TGFβ signal inhibitor, and further culturing the telencephalon marker-positive aggregate in suspension under a high oxygen partial pressure condition. In one embodiment, the suspension culture under a high oxygen partial pressure condition is performed in the presence of a Wnt signal enhancer and a bone morphogenetic factor signal transduction pathway activating substance. | 2016-10-06 |
20160289636 | Generation of Patient-Specific Differentiated Cell Types by Epigenetic Induction - Disclosure of a mammalian cytoplasmic donor cell line. Disclosure of a patient specific cell line. Methods to obtain a mammalian cytoplasmic donor cell line by fusing a differentiated mammalian cell and a functionally enucleated mammalian embryonic cell line. Methods to obtain a mammalian cytoplasmic donor cell line by fusing a differentiated mammalian cell and a functionally enucleated human cancer cell. Methods to obtain a patient specific cell line of a cell type similar to a mammalian cytoplasmic donor cell line by functionally enucleating the mammalian cytoplasmic donor cell line and fusing the functionally enucleated mammalian cytoplasmic donor cell line with a differentiated cell obtained from the patient. A method of treatment of a human patient by administering the patient-specific cell line to the patient. | 2016-10-06 |
20160289637 | COMPOSITION AND METHODS OF GENOME EDITING OF B-CELLS - The present invention provides methods compositions and methods of preparing autologous (or allogeneic) B cells that secrete a monoclonal of interest useful in immunotherapy or B cells with an altered function. | 2016-10-06 |
20160289638 | Systems And Methods For Leukoreducing A Red Blood Cell-Containing Fluid And Concentrated Red Blood Cells - Systems and methods are provided for separating a red blood cell-containing fluid into separated red blood cells and another fluid constituent. A suitable system includes a disposable fluid flow circuit and a durable, reusable separation system, with the circuit being mounted onto or otherwise associated with the separation system. The circuit includes a membrane separator for separating the fluid into its constituent parts, as well as a leukoreduction filter. The leukoreduction filter may be used before or after the red blood cell-containing fluid has been passed into the membrane separator. The red blood cell-containing fluid (if the leukoreduction filter is positioned upstream of the membrane separator) or the separated red blood cells (if the leukoreduction filter is positioned downstream of the membrane separator) may also be passed through a microaggregate filter prior to passing through the leukoreduction filter. | 2016-10-06 |
20160289639 | METHOD AND COMPOSITION FOR INDUCING CHONDROGENESIS OR TENOGENESIS IN MESENCHYMAL STEM CELLS - The current invention concerns a cell medium for in vitro inducing chondrogenesis or tenogenesis in mesenchymal stem cells (MSCs). The medium includes a glucose medium supplemented with at least one growth factor. The growth factor is selected from fibroblast growth factors (FGF) or transforming growth factors (TGF). FGF or TGF is present in a total concentration of between 1 and 15 ng/ml. In both cases, IGF can be added to enhance the induction process. In a further aspect, the invention provides for a use of such cell medium as well as a method for inducing isolated mesenchymal stem cells (MSCs) and a cell composition obtained by such method. | 2016-10-06 |
20160289640 | MTOR/STAT3 SIGNAL INHIBITOR-TREATED MESENCHYMAL STEM CELL HAVING IMMUNOMODULATORY ACTIVITY, AND CELL THERAPY COMPOSITION COMPRISING SAME, FOR PREVENTING OR TREATING IMMUNE DISORDERS - The present invention relates to a mesenchymal stem cell having immunomodulatory activity and a preparation method therefor and, more specifically, to: a rapamycin-treated mesenchymal stem cell having immunomodulatory activity, which expresses any one or more cell surface factors selected from the group consisting of CCR1, CCR2, CCR3, CCR4, CCR7, CCR9 and CXCR4; a cell therapy composition comprising the mesenchymal stem cell, for preventing or treating immune disorders; and a preparation method for the mesenchymal stem cell having immunomodulatory activity. The rapamycin-treated mesenchymal stem cell having immunomodulatory activity, according to the present invention, has increased expression of IDO, TGF-β and IL-10 which are factors having immunomodulatory activity, has decreased expression of Phospho-mTOR, Rictor and Ractor which are signal transduction factors of mTOR, and has increased expression, in the cell, of autophagic inducer Beclin1, ATG5, ATG7, LC3I or LCII. If this cell is used as a cell therapy in individuals having immune disorders, it is possible to effectively treat immune disorders. | 2016-10-06 |
20160289641 | METHOD FOR PROMOTING HAIR GROWTH USING COMPOSITION COMPRISING PDGF-D TREATED ADIPOSE-DERIVED STEM CELLS - Provided is a composition for promoting hair growth comprising platelet-derived growth factor-D (PDGF-D)-treated adipose-derived stem cells (ASCs) as an active ingredient, and more particularly, a therapeutic agent for hair loss comprising ASCs with increased proliferation and migration by PDGF-D and increased expression and secretion of a growth factor as an active ingredient. PDGF-D-treated ASCs have improved hair regenerative potential through the increases in proliferation, migration and growth factor secretion and thus are useful for a therapeutic agent for hair loss or a cosmetic for preventing hair loss. | 2016-10-06 |
20160289642 | METHOD FOR GENERATING PANCREATIC HORMONE-PRODUCING CELLS - Provided is a method for inducing pancreatic hormone-producing cells from pancreatic progenitor cells efficiently. The method comprises a step of culturing the cells in a culture medium comprising sodium cromoglicate. | 2016-10-06 |
20160289643 | Immortalization of Epithelial Cells and Methods of Use - The present invention is directed towards methods of culturing non-keratinocyte epithelial cells, with the methods comprising culturing non-keratinocyte epithelial cells in the presence of feeder cells and a calcium-containing medium while inhibiting the activity of Rho kinase (ROCK) in the feeder cell, the non-keratinocyte epithelial cells or both during culturing. | 2016-10-06 |
20160289644 | Immortalization of Epithelial Cells and Methods of Use - The present invention is directed towards methods of culturing non-keratinocyte epithelial cells, with the methods comprising culturing non-keratinocyte epithelial cells in the presence of feeder cells and a calcium-containing medium while inhibiting the activity of Rho kinase (ROCK) in the feeder cell, the non-keratinocyte epithelial cells or both during culturing. | 2016-10-06 |
20160289645 | Adenovirus Expressing Immune Cell Stimulatory Receptor Agonist(s) - Certain embodiments include the enhancement of effectiveness for an adenoviral cancer therapy. | 2016-10-06 |
20160289646 | MANIPULATING THE CIRCADIAN CLOCK TO INCREASE GENE EXPRESSION - A method of increasing gene expression by manipulating the circadian clock is described that includes transforming a photosynthetic organism to include an expression control sequence that modulates the expression of a clock gene to increase expression of a target gene. Photosynthetic organism having a modified circadian cycle reflecting this method are also described. | 2016-10-06 |
20160289647 | PROKARYOTIC DESATURASES MODIFIED BY DIRECTED EVOLUTION TO REDUCE SATURATED AND INCREASE UNSATURATED FATTY ACIDS IN EUKARYOTES - Transgenic eukaryotic (animal, plant and fungal) cells and organisms that contain decreased levels of saturated fatty acids are provided. The transgenic eukaryotic cells and organisms have been genetically engineered to contain and express heterologous prokaryotic enzymes with enhanced desaturase activity. Products made by or from the cells and organisms are also provided. | 2016-10-06 |
20160289648 | NUCLEIC ACIDS ENCODING PLANT GLUTAMINE PHENYLPYRUVATE TRANSAMINASE (GPT) AND USES THEREOF - Glutamine phenylpyruvate transaminase (GPT) proteins, nucleic acid molecules encoding GPT proteins, and uses thereof are disclosed. Provided herein are various GPT proteins and GPT gene coding sequences isolated from a number of plant species. As disclosed herein, GPT proteins share remarkable structural similarity within plant species, and are active in catalyzing the synthesis of 2-hydroxy-5-oxoproline (2-oxoglutaramate), a powerful signal metabolite which regulates the function of a large number of genes involved in the photosynthesis apparatus, carbon fixation and nitrogen metabolism. | 2016-10-06 |
20160289649 | BIOCATALYSTS AND METHODS FOR SYNTHESIZING DERIVATIVES OF TRYPTAMINE AND TRYPTAMINE ANALOGS - The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents. | 2016-10-06 |
20160289650 | FLUORESCENT PROTEIN BIOSENSORS TO PROBE THE CONFORMATIONAL ACTIVATION OF CDK/CYCLIN KINASES - The present invention relates to compounds comprising a polypeptide comprising an amino acid sequence derived from the sequence of a cyclin-dependent kinase (CDK) and at least one fluorophore coupled to an amino acid of said polypeptide. The invention also relates to said compounds associated with a technology enabling their intracellular delivery. The present invention also relates to the use of such compounds, or of compositions comprising said compounds, for determining if a product is capable of modulating the conformation of a CDK. More particularly, a compound according to the invention is usable for high-content high-throughput screening. | 2016-10-06 |
20160289651 | ULK1 COMPOSITIONS, INHIBITORS, SCREENING AND METHODS OF USE - This disclosure relates to methods and compositions useful for the treatment of cancer and diseases and disorders associated with autophagy. | 2016-10-06 |
20160289652 | STABILIZED REVERSE TRANSCRIPTASE FUSTION PROTEINS - Stabilized reverse transcriptase fusion proteins including a thermostable reverse transcriptase connected to a stabilizer protein are described. Attaching the stabilizer protein to the thermostable reverse transcriptase stabilizes the fusion protein and can aid in its purification, provide increased solubility, allow for longer storage, or allow the fusion protein to be used under more rigorous conditions such as higher temperature. The stabilized reverse transcriptase fusion protein can also include a linker between the stabilizer protein and the thermostable reverse temperature. The stabilized reverse transcriptase fusion proteins are suitable for use in nucleic acid amplification methods such as the reverse transcription polymerase chain reaction and other applications involving cDNA synthesis. | 2016-10-06 |
20160289653 | Stable Enzymes by Glycation Reduction - The present teachings provide enzymes with improved stability arising from reduced glycation. Glycation reduction can be achieved by a variety of means, including protein engineering, heating to remove background ground starch hydrolytic activity, diafiltration afiltration, and various formulation approaches including non-inclusion of problematic sugars, and inclusion of resistant starches. | 2016-10-06 |
20160289654 | Organophosphorous Hydrolase Variants - The present invention relates to organophosphorous hydrolase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants. | 2016-10-06 |
20160289655 | Thermostable Phytase Variants - The present invention relates to a phytase which has at least 70% identity to a phytase derived from | 2016-10-06 |
20160289656 | METHODS OF PRODUCING CARBOXYLIC ACIDS - The invention relates to methods for enriching monomer content in a cycloalkane oxidation process mixed organic waste stream. In particular, the methods involve combining a biocatalyst with a mixed organic waste stream from a cycloalkane oxidation process, and enzymatically converting dimeric and/or oligomeric components of said waste stream into monomeric components. The methods may enrich the content of diacids, adipic acid, and/or other α,ω-difunctional C6 alkanes in the mixed organic waste stream. Additionally, the treated mixed organic waste streams may have improved burning efficiency. | 2016-10-06 |
20160289657 | ACETYLCHOLINESTERASE-Fc DOMAIN FUSION PROTEIN - Fusion polypeptides are provided including modified human Acetylcholinesterase conjugated to the Fc region of an immunoglobulin. Methods of preparing these polypeptide constructs and uses thereof as scavenging agents of organophosphate compounds are described. | 2016-10-06 |
20160289658 | Polypeptides Having Phospholipase A Activity and Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having phospholipase A activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2016-10-06 |
20160289659 | METHODS AND COMPOSITIONS FOR MODIFYING A SINGLE STRANDED TARGET NUCLEIC ACID - The present disclosure provides compositions and methods for binding and/or cleaving a single stranded target nucleic acid. Subject compositions include a Cas9 polypeptide, a guide nucleic acid, and a PAMmer. A subject PAMmer is a single stranded oligonucleotide having a protospacer adjacent motif (PAM) sequence and at least one of: a specificity segment positioned 5′ of the PAM sequence, and an orientation segment positioned 3′ of the PAM sequence. In some embodiments, the Cas9 polypeptide is a variant Cas9 polypeptide having reduced nuclease activity relative to a corresponding wild type Cas9 polypeptide. In some cases, methods of binding are for visualizing single stranded target nucleic acids using a detectable label. In some cases, methods of binding are for isolating, collecting, and/or analyzing at least one of: (i) bound single stranded target nucleic acids; and (ii) polypeptides associated with bound single stranded target nucleic acids. | 2016-10-06 |
20160289660 | High Fidelity Restriction Endonucleases - Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer. | 2016-10-06 |
20160289661 | ENDOGLUCANASE VARIANTS HAVING IMPROVED ACTIVITY, AND USES OF SAME - The present invention relates to the expression and optimisation of enzymes involved in the breakdown of lignocellulosic biomass. The present invention relates more specifically to variants of | 2016-10-06 |
20160289662 | COMPOSITION FOR DISPERSING BIOLOGICAL TISSUE - The purpose of the present invention is to acquire a highly proliferative cell at a high efficiency from a sample derived from a biological tissue. Provided is a composition for dispersing a biological tissue, wherein a solution formulation of the composition has a collagenase activity of 0.30-10 U/mL, said collagenase activity being determined by a method for measuring FALGPA-decomposing activity, and a trypsin activity of 0-30 U/mL at a formulation concentration of the composition, said trypsin activity being determined by a method for measuring BASE hydrolytic activity. | 2016-10-06 |
20160289663 | NOVEL CHIMERIC GENE ATF7IP-PDGFRB OF ACUTE LYMPHOBLASTIC LEUKEMIA - To identify a mutation that can serve as an indicator for predicting the effectiveness of drug treatment in cancers such as leukemia; to provide a means for detecting said mutation; and to provide a means for identifying, based on said mutation, patients with cancer or subjects with a risk of cancer, in whom a drug targeting a gene having said mutation or a protein encoded by said gene shows a therapeutic effect. | 2016-10-06 |
20160289664 | ACTIVATED PLATELET COMPOSITION WITH TUNABLE GROWTH FACTOR LEVEL - Methods and systems for generating a tunable or customizable activated product composition are related. In certain embodiments, one or more of electric pulse parameters, flow rate, or sample container size are varied so as to generate the activated product composition. The activated product composition may be customized or optimized based for a particular patient or procedure. | 2016-10-06 |
20160289665 | NUCLEIC ACID EXTRACTION APPARATUS - The present invention provides a nucleic acid extraction instrument including a base, an outer housing connected with the base, and an instrumental main body positioned inside the outer housing and mounted to the base; and the instrumental main body includes an electrical power pack, a main control device, a first motor set, a second motor set, and a third motor set. | 2016-10-06 |
20160289667 | ACCELERATED DIRECTED EVOLUTION OF MICROBIAL CONSORTIA FOR THE DEVELOPMENT OF DESIRABLE PLANT PHENOTYPIC TRAITS - The disclosure relates to methods for the screening, identification, and/or application of one or more microorganisms of use in imparting one or more beneficial properties to one or more plants. | 2016-10-06 |
20160289668 | Production Method for Charged Non-Protein Amino Acid-Containing Peptide - An object of the present invention is to provide a method of producing a peptide containing a charged non-proteinogenic amino acid in a cell-free translation system, and the like. | 2016-10-06 |
20160289669 | DEVICES AND SYSTEMS FOR MOLECULAR BARCODING OF NUCLEIC ACID TARGETS IN SINGLE CELLS - Disclosed herein are devices and systems comprising a) a substrate comprising at least 100 microwells and a plurality of beads, wherein a plurality of the at least 100 microwells each contain a single bead, and wherein the ratio of the average diameter of the microwells to the diameter of the beads ranges from about 1.2 to about 1.8; b) a flow cell in fluid communication with the substrate; and c) at least one inlet port and at least one outlet port, wherein the at least one inlet port and at least one outlet port are capable of directing a flow of a fluid through the flow cell, thereby contacting the microwells with the fluid. | 2016-10-06 |
20160289670 | COMPOSITIONS AND METHODS FOR MOLECULAR LABELING - The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR. | 2016-10-06 |
20160289671 | METHOD OF MANUFACTURING PROTEIN ARRAY OR PEPTIDE ARRAY, METHOD OF IDENTIFYING FUNCTIONAL PROTEIN OR FUNCTIONAL PEPTIDE, PROTEIN ARRAY OR PEPTIDE ARRAY, AND FUNCTIONAL PROTEIN OR FUNCTIONAL PEPTIDE IDENTIFICATION KIT - There is provided a method of manufacturing a protein array or peptide array suitable for an efficient screening of a functional protein or functional peptide. The method of manufacturing a protein array or peptide array includes the steps of: (a) preparing a nucleic acid immobilized on a solid support and a cell-free synthesis system in a reactor, in which a reactor array includes the reactor having a specific aperture shape and a protein capture molecule or a peptide capture molecule provided on at least a portion of wall surface and bottom surface in the reactor; and (c) synthesizing a protein or peptide from the nucleic acid using the cell-free synthesis system and immobilizing the protein or peptide in the reactor. | 2016-10-06 |
20160289672 | High Throughput Screening of Enzyme Libraries - Provided herein, among other things, is method comprising: a) placing a planar absorbent support comprising an in vitro transcription and translation (IVTT) mix impregnated therein in contact with an array of in situ-assembled expression cassettes; and b) incubating the planar absorbent support and array under conditions by which the expressed cassettes are transcribed and translated by the impregnated IVTT components, thereby producing an array of proteins. Screening methods that employ the array of proteins are also provided. | 2016-10-06 |
20160289673 | OPTIMIZED SMALL GUIDE RNAS AND METHODS OF USE - Methods, compositions, and kits are provided herein for CRISPER/Cas-mediated nucleic acid detection or modification. | 2016-10-06 |
20160289674 | MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF MEMBRANE PROTEINS - The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules. | 2016-10-06 |
20160289675 | Guide RNA with chemical modifications - The present invention relates to modified guide RNAs and their use in clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems. | 2016-10-06 |
20160289676 | COMPOSITIONS AND METHODS FOR INHIBITING NF- kB AND SOD-1 TO TREAT AMYOTROPHIC LATERAL SCLEROSIS - The invention relates to pharmaceutical compositions, kits, methods, and uses for the treatment of amyotrophic lateral sclerosis. In particular, the invention relates to compositions, kits, methods, and uses for the treatment of amyotrophic lateral sclerosis by inhibiting NF-κB in microglia or macrophages and by inhibiting motor neuron death. The invention further relates to compositions, kits, methods, and uses for the treatment of amyotrophic lateral sclerosis by inhibiting NF-κB in microglia in combination with inhibiting SOD-1 in astrocytes. The invention also relates to a method for inhibiting the expression or the activity of NF-κB in microglia or macrophages to inhibit motor neuron death, alone or in combination with inhibiting SOD-1 expression in astrocytes. | 2016-10-06 |
20160289677 | APOB Antisense Conjugate Compounds - The present invention relates to conjugates of antisense oligonucleotides (oligomers) that target the APOB gene at position 2265 to 2277. | 2016-10-06 |
20160289678 | USE OF MICRORNA 146-A IN THE DIAGNOSIS, TREATMENT AND PREVENTION OF PICORNAVIRUS INFECTION AND MICRORNA 146-A ANTAGONISTS - The present invention found that host miRNAs might be involved in Picornavirus pathogenesis through suppression of type I IFNs induction and could act as candidates for developing antiviral therapy. Thus, the invention suggests enterovirus-induced miR-146a facilitates viral pathogenesis by suppressing IFN production and provide a clue to develop the preventive and therapeutic strategies for enterovirus infections. | 2016-10-06 |
20160289679 | NUCLEIC ACID LIGANDS TO LL37 - The present invention is directed to nucleic acid ligands to LL37, methods for producing said nucleic acid ligands, and methods for utilizing said nucleic acid ligands. In one exemplary embodiment, for example, this invention relates to nucleic acid ligands exhibiting high specific binding affinity to LL37 peptides, precursors and/or portions thereof. Further, the nucleic acid ligands may bind competitively with native ligands of LL37 and may also inhibit and/or interfere with LL37 function, such as by binding to LL37. | 2016-10-06 |
20160289680 | METHOD FOR PREPARING NUCLEIC ACID APTAMER - An object of the present invention is to develop and provide a method for efficiently and conveniently producing a nucleic acid aptamer, particularly, a DNA aptamer, having high specificity for and high binding activity against a target substance. | 2016-10-06 |
20160289681 | RNA-BASED HIV INHIBITORS - Provided herein are, inter alia, antiviral recombinant nucleic acid compositions and methods of using the same. The recombinant nucleic acid compositions include nucleic acids encoding antiviral polycistronic RNAs, which are capable of inhibiting viral replication. The antiviral recombinant nucleic acid compositions provided herein are therefore particularly useful for therapeutic applications such as combinational HIV-1 gene therapy. | 2016-10-06 |
20160289682 | PRODUCTION AND UTILIZATION OF A NOVEL ANTI-CANCER DRUG IN THERAPY - This invention generally relates to a design and method for developing novel anti-tumor and/or anti-cancer drugs, vaccines and therapies, using microRNA and/or its shRNA homologues/mimics/derivatives. More specifically, the present invention relates to an use of a prokaryote-produced miRNA precursor (pro-miRNA) composition capable of being delivered into human cells and processed by the cells into mature miRNA effectors to elicit specific silencing effects on mir-302-targeted genes, subsequently leading to a beneficial result of tumor suppression and cancer therapy. The prokaryotic cells do not naturally express or process eukaryotic miRNA precursors (pre-miRNA); meanwhile, the present invention also teaches an inducible method for expressing pre-miRNAs, particularly mir-302 precursors by using the prokaryotic transcription system. Since mir-302 is a known tumor suppressor in human, this novel finding advances the design and method for developing new anti-cancer drugs, vaccines and/or therapies directed against multiple kinds of human tumors and cancers. | 2016-10-06 |
20160289683 | Mutator Activity Induced by microRNA-155 (miR-155) Links Inflammation and Cancer - Methods of reducing spontaneous mutation rate of a cell in a subject in need thereof by reducing endogenous levels of miR-155 are described. | 2016-10-06 |
20160289684 | USE OF IKK EPSILON INHIBITORS TO ACTIVATE NFAT AND T CELL RESPONSE - Disclosed herein are compositions and methods of activating nuclear factor of activated T cells (NFAT) and T cell response by inhibiting IKKε. | 2016-10-06 |
20160289685 | PARP9 AND PARP14 AS KEY REGULATORS OF MACROPHAGE ACTIVATION - The invention relates to compositions and methods for inhibiting macrophage activation via modulating PARP9 and/or PARP14 expression or activity, such as small molecules, RNAi and antibodies. Modulating the expression and/or activity of PARP9 and/or PARP14 allows the inhibition of monocytes or macrophage M1 activation and inflammation. Inhibiting undesirable excessive or sustained inflammation found in humans, for the treatment, prevention and/or management of conditions where undesirable excessive or sustained inflammation is known or likely to contribute to the onset, development and/or progression the conditions. | 2016-10-06 |
20160289686 | METHODS FOR IDENTIFYING THERAPEUTIC TARGETS AND TREATING MONITORING CANCERS - The present invention provides methods for treating cancers having a mutation in one or more tumor suppressor genes, comprising providing to a subject in need thereof an inhibitor of a kinase, as well as related methods and compositions. | 2016-10-06 |
20160289687 | SMALL INTERFERENCE RNAS, USES THEREOF AND METHOD FOR INHIBITING THE EXPRESSION OF PLK1 GENE - The present invention provides siRNAs for inhibiting the expression of plk1 gene, and the method for inhibiting the expression of plk1 gene in mammalian cells. The siRNAs of the present invention have the double-stranded structure, and said double-stranded structure is composed of the first single strand and the second single strand that are fully complementary, wherein the sequence of said first single strand is the same as the target sequence within the sequence as shown in SEQ ID NO: 1, and the sequence of said second single strand is complementary to the target sequence within the sequence as shown in SEQ ID NO: 1. The siRNAs of the present invention can sequence specifically mediate the inhibition of plk1 gene expression, and have a good serum stability. By the introduction of the siRNAs of the present invention into the tumor cells, the expression of plk1 gene can be effectively inhibited, and the growth of tumor cells is inhibited and the apoptosis of tumor cells is promoted. | 2016-10-06 |
20160289688 | COMPOSITIONS AND METHODS FOR USE IN TREATING SILICOSIS AND LUNG CANCER - A method for treating an inflammatory disease is provided. The method comprises administering an effective amount of a BLT1 inhibitor to a subject in need thereof. The BLT1 inhibitor is selected from the group consisting of a BLT1 receptor antagonist, a small molecule, a polypeptide, an siRNA, or a combination thereof. | 2016-10-06 |
20160289689 | METHOD FOR TRANSFORMATION OF STRAMENOPILE - To provide a transformation method for producing a stramenopile organism having an improved unsaturated fatty acid production capability by disrupting a gene of the stramenopile organism or inhibiting the expression of the gene in a genetically engineering manner. [Solution] A method for transforming a stramenopile organism, which comprises disrupting a gene of the stramenopile organism or inhibiting the expression of the gene in a genetically engineering manner, and which is characterized in that the stramenopile organism is selected from | 2016-10-06 |
20160289690 | MORTIERELLA ALPINA RECOMBINANT GENE EXPRESSION SYSTEM AND CONSTRUCTION METHOD AND USE THEREOF - It relates to a | 2016-10-06 |
20160289691 | METHODS AND COMPOSITIONS FOR INCREASING EFFICIENCY OF INCREASED EFFICIENCY OFTARGETED GENE MODIFICATION USING OLIGONUCLEOTIDE-MEDIATED GENE REPAIR - The invention provides to improved methods for the modification of genes in plant cells, and plants and seeds derived therefrom. More specifically, the invention relates to the increased efficiency of targeted gene mutation by combining gene repair oligonucleotides with approaches that enhance the availability of components of the target cell gene repair mechanisms. | 2016-10-06 |
20160289692 | Vectors and Methods For Enhancing Recombinant Protein Expression in Plants - Expression vectors and methods of their use for enhancing the production of recombinant proteins in plants or plant cells are described. Production can be further enhanced upon co-expression of the P19 suppressor of gene-silencing from tomato bushy stunt virus. Preferably, the recombinant proteins are therapeutic enzymes and/or antibodies and methods are carried out in | 2016-10-06 |
20160289693 | PLANT REGULATORY ELEMENTS AND USES THEREOF - The present invention provides novel DNA molecules and constructs, including their nucleotide sequences, useful for modulating gene expression in plants and plant cells. The invention also provides transgenic plants, plant cells, plant parts, seeds, and commodity products comprising the DNA molecules operably linked to heterologous transcribable polynucleotides, along with methods of their use. | 2016-10-06 |
20160289694 | PLANTS HAVING INCREASED BIOMASS AND METHODS FOR MAKING THE SAME - The impact of plastid size change in both monocot and dicot plants has been examined. In both, when plastid size is increased there is an increase in biomass relative to the parental lines. Thus, provided herein are methods for increasing the biomass of a plant, comprising decreasing the expression of at least one plastid division protein in a plant. Optionally, the level of chlorophyll in the plant is also reduced. | 2016-10-06 |
20160289695 | GENETICALLY ENGINEERED MICROBIAL STRAINS INCLUDING PROTOTHECA LIPID PATHWAY GENES - Genetically engineered microbial, e.g., | 2016-10-06 |
20160289696 | MUTANT SORGHUM BICOLOR HAVING ENHANCED SEED YIELD - Genetically altered sorghum plants expressing the multi-seeded #2 phenotype contain one of two genomic alterations in the Sb06g018040 gene which result in reduced activity of the encoded protein, a class II 13-lipoxygenase. This phenotype and genotype are referred to as msd2. These alterations result in increased number of seeds and seed weight, thus increasing the yield of the genetically altered plant. These alterations can be generated in the ortholog genes in maize (TS1), rice, barley, and other monocot plants, generating the MSD2 phenotype. The seeds of one particular MSD2 | 2016-10-06 |
20160289697 | AP2 DOMAIN TRANSCRIPTION FACTOR ODP2 (OVULE DEVELOPMENT PROTEIN 2) AND METHODS OF USE - Methods and compositions for modulating plant development are provided. Nucleotide sequences and amino acid sequences encoding Ovule Development Protein 2 (ODP2) proteins are provided. The sequences can be used in a variety of methods including modulating development, developmental pathways, altering oil content in a plant, increasing transformation efficiencies, modulating stress tolerance, and modulating the regenerative capacity of a plant. Transformed plants, plant cells, tissues, and seed are also provided. | 2016-10-06 |
20160289698 | COMPOSITIONS AND METHOD FOR MODULATING THE SENSITIVITY OF PLANTS TO CYTOKININ - The present invention includes an expression cassette containing a polynucleotide encoding a polypeptide; and a host cell, transgenic plant (e.g., a dicot or monocot), transformed seed, and transgenic rootstock containing said expression cassette. Methods for desensitizing a plant to endogenous cytokinin; increasing seed, embryo or cotyledon size or weight; increasing the seed yield of a plant; and/or increasing the size of the root or root meristem or formation of lateral or adventitious roots are provided. In some embodiments, expression of the polypeptide is under control of a seed-preferred, embryo-preferred or root-preferred promoter. | 2016-10-06 |
20160289699 | TARGETED INTEGRATION INTO THE PPP1R12C LOCUS - Disclosed herein are methods and compositions for targeted integration of an exogenous sequence into the human PPP1R12C locus, for example, for expression of a polypeptide of interest. | 2016-10-06 |
20160289700 | COMPOSITIONS AND METHODS RELATED TO A TYPE-II CRISPR-CAS SYSTEM IN LACTOBACILLUS BUCHNERI - The present invention is directed to methods and compositions for typing of | 2016-10-06 |
20160289701 | Biosynthesis of 1-Undecene and Related Terminal Olefins - The present disclosure relates to the biosynthesis of 1-undecene and related terminal olefins. Specifically, the present disclosure relates to methods of using proteins to produce 1-undecene and related terminal olefins. | 2016-10-06 |
20160289702 | Biosynthetic Mint - A method for producing a menthol isomer is disclosed, comprising: (i) providing a microorganism modified to have increased expression of an ene reductase and one or more menthone dehydrogenase; (ii) contacting said microorganism, or a protein-containing extract thereof, with a biosynthetic precursor of said menthol isomer; and (iii) maintaining the mixture of step (ii) under conditions suitable for biotransformation of said biosynthetic precursor to said menthol isomer. | 2016-10-06 |
20160289703 | EFFICIENT BIOMASS FRACTIONATING SYSTEM FOR AN ENERGY PULSE CROP - An efficient biomass fractionating system for an energy pulse crop is provided. Pulses include, e.g., peas, beans, and lentils. A method and ecosystem model applies a premium utilization to each fraction of a pulse crop so that no fraction is treated as waste. The methods may also be applied to other alternative crops, such as chestnut seeds, banana and | 2016-10-06 |
20160289704 | PROCESSING BIOMASS AND PETROLEUM CONTAINING MATERIALS - Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems can use feedstock materials, such as cellulosic and/or lignocellulosic materials and/or starchy materials, to produce ethanol and/or butanol, e.g., by fermentation. | 2016-10-06 |
20160289705 | PROCESSING BIOMASS AND PETROLEUM CONTAINING MATERIALS - Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems can use feedstock materials, such as cellulosic and/or lignocellulosic materials and/or starchy materials, to produce ethanol and/or butanol, e.g., by fermentation. | 2016-10-06 |
20160289706 | PROCESSING BIOMASS AND PETROLEUM CONTAINING MATERIALS - Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems can use feedstock materials, such as cellulosic and/or lignocellulosic materials and/or starchy materials, to produce ethanol and/or butanol, e.g., by fermentation. | 2016-10-06 |
20160289707 | PROCESS FOR BIOFUEL AND BIOCHEMICAL PRODUCTION, CULTURE MEDIUM AND BIOFUEL AND BIOCHEMICAL PRODUCED - The present invention relates to a process and a culture medium for biofuel and biochemical production by fermentation of lignocellulose biomass. The process describes the use of a solid-liquid mixed blend formed by solid fiber pulp, hydrolysate, and a polypeptide complex. The solid fiber pulp is partially degraded by the polypeptide complex allowing microbe immobilization and, at the same time, releasing substances that affect | 2016-10-06 |
20160289708 | METHODS AND COMPOSITIONS FOR PRODUCTION OF ACETALDEHYDE - The present disclosure provides methods for producing acetaldehyde from renewable biological resources, for example, from a fermentable substrate, with the advantages of energy efficiency and ease of purification. Particular embodiments, feature the production of acetaldehyde from pyruvate, wherein the pyruvate is generated from various carbon sources (e.g., sugars) by pyruvate-producing microorganisms. The methods comprise culturing a pyruvate-producing microorganism in a culture medium under conditions such that pyruvate is excreted and accumulates extracellularly, resulting in a pyruvate-enriched medium. | 2016-10-06 |
20160289709 | PROCESSING BIOMASS - Biomass (e.g., plant biomass, animal biomass, microbial, and municipal waste biomass) is processed to produce useful products, such as food products and amino acids. | 2016-10-06 |
20160289710 | PROCESSING BIOMASS - Biomass (e.g., plant biomass, animal biomass, microbial, and municipal waste biomass) is processed to produce useful products, such as food products and amino acids. | 2016-10-06 |
20160289711 | METHOD FOR PRODUCING POLYMER, METHOD FOR PRODUCING ORGANIC ACID, AND ORGANIC ACID-PRODUCING MICROORGANISM - The present invention provides a method of producing a polymer, which comprises the step of performing a polymerization reaction using, as a starting material, an organic acid obtained by allowing a microorganism or a treated cell thereof to act on an organic raw material, wherein said microorganism has an ability to produce an organic acid and has been modified so as to produce less aromatic carboxylic acid as compared to an unmodified strain. | 2016-10-06 |
20160289712 | PAENIBACILLUS SP. CAA11 CAPABLE OF SACCHARIFICATION AND FERMENTATION OF CELLULOSE AND TRANSFORMED STRAIN THEREOF - The present disclosure relates to a novel strain capable of saccharifying and fermenting biomass-derived cellulose and a recombinant strain thereof with improved biomass saccharification capability. The present disclosure also relates to a method for producing a material useful as a bioenergy source material such as ethanol, acetic acid, formic acid, etc. using the strain or the recombinant strain. The strain or the recombinant strain may be usefully used in bioenergy industry. | 2016-10-06 |
20160289713 | DESIGNER CELLS FOR ENANTIOSELECTIVE REDUCTION OF KETONES AND USE THEREOF IN EFFICIENT PRODUCTION OF ENANTIOENRICHED ALCOHOLS - The present invention is to provide a preparation of variant recombinant whole cell biocatalysts, referred herein as “designer cells” having significantly enhanced carbonyl reductase activity for use in the efficient production of variant industrially important enantiomerically enriched alcohols. More specifically, the alcohol is optically pure ethyl (S)-4-chloro-3-hydroxybutyrate, which is useful as chiral building block and an intermediate for the production of hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors. | 2016-10-06 |
20160289714 | BIOREFINERY SYSTEM, METHODS AND COMPOSITIONS THEREOF - The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C | 2016-10-06 |
20160289715 | METHOD FOR PRODUCING OPTICALLY ACTIVE AMINE COMPOUNDS BY DERACEMIZATION - Disclosed are methods for producing optically active amino acids and amines. According to the methods, α-keto acids are generated as reaction intermediates, and as a result, ω-transaminase-catalyzed kinetic resolution of racemic amino acids or amines as racemic amine compounds enables the production of optically active amine compounds without the need to use expensive α-keto acids as starting materials. Therefore, the optically active amine compounds are produced at greatly reduced costs. In addition, the optically active amine compounds have high enantiomeric excess. | 2016-10-06 |
20160289716 | Novel Gene and Method for Producing L-Amino Acids - The present invention describes a bacterium which has an ability to produce an amino acid and in which the rhtC gene encoding a protein having an enhanced activity of imparting L-threonine resistance to a bacterium expressing the protein. Preferably, the bacterium further includes an rhtB gene encoding for a protein having an enhanced activity of imparting to a bacterium L-homoserine resistance expressing the protein. The present invention also describes a method of cultivating the bacterium in a culture medium to produce and accumulate amino acids in the medium, and the amino acid is recovered from the medium. | 2016-10-06 |
20160289717 | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF (R)-3-HYDROXYTHIOLANE - The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds. | 2016-10-06 |
20160289718 | PROCESS FOR THE PREPARATION OF CHIRAL 2-ARYL MORPHOLINES - The invention relates to a novel process for the preparation of chiral 2-(4-aminophenyl) morpholines of the formula | 2016-10-06 |