40th week of 2016 patent applcation highlights part 31 |
Patent application number | Title | Published |
20160289719 | MODIFICATION OF THE XYLAN UTILIZATION SYSTEM FOR PRODUCTION OF ACIDIC XYLOOLIGOSACCHARIDES FROM LIGNOCELLULOSICS - The subject invention pertains to genetically modified microorganisms, e.g., genetically modified | 2016-10-06 |
20160289720 | METHODS OF COMPRESSING LIGNOCELLULOSIC FEEDSTOCK INTO DISCRETE UNITS, AND RELATED SYSTEMS - The present disclosure relates to methods of processing lignocellulosic feedstock that include grinding lignocellulosic feedstock to provide ground lignocellulosic feedstock; and compressing at least a portion of the ground lignocellulosic feedstock to form at least one discrete unit. In some embodiments, a plurality of discrete units have a bulk density in the range from 4 pounds per cubic foot to 25 pounds per cubic foot. The present disclosure also includes related systems. | 2016-10-06 |
20160289721 | DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF - A method of diversification of human milk oligosaccharides (HMOs) or precursors thereof, compounds obtainable by the method, and uses and compositions involving such compounds. The method comprises a) providing at least one compound or a mixture of the compounds selected from the group consisting of: optionally sialylated and/or fucosylated lactose derivatives of general formula 2 and salts thereof; b) adding at least one enzyme comprising a transglycosidase activity to the at least one compound or a mixture of compounds provided according to step a); and c) incubating the mixture obtained according to step b). | 2016-10-06 |
20160289722 | Methods For Degrading or Converting Plant Cell Wall Polysaccharides - The present invention relates to methods for converting plant cell wall polysaccharides into one or more products, comprising: treating the plant cell wall polysaccharides with an effective amount of a spent whole fermentation broth of a recombinant microorganism, wherein the recombinant microorganism expresses one or more heterologous genes encoding enzymes which degrade or convert the plant cell wall polysaccharides into the one or more products. The present invention also relates to methods for producing an organic substance, comprising: (a) saccharifying plant cell wall polysaccharides with an effective amount of a spent whole fermentation broth of a recombinant microorganism, wherein the recombinant microorganism expresses one or more heterologous genes encoding enzymes which degrade or convert the plant cell wall polysaccharides into saccharified material; (b) fermenting the saccharified material of step (a) with one or more fermenting microoganisms; and (c) recovering the organic substance from the fermentation. | 2016-10-06 |
20160289723 | METHODS AND COMPOSITIONS FOR REPAIR OF DNA ENDS BY MULTIPLE ENZYMATIC ACTIVITIES - Provided herein are compositions for and methods of generating ligation-competent nucleic acids. In some aspects, the compositions comprise Exonuclease III, T4 DNA Polymerase, Klenow, and/or T4 polynucleotide kinase. | 2016-10-06 |
20160289724 | METHOD FOR PRODUCING BIOGENIC SUBSTANCES - This invention relates to a biogenic substance production process wherein a) at least one starting material has b) at least one enzyme added to it and the product resulting from b) has c) at least one liver cell added to it, and d) at least one biogenic substance is isolated. | 2016-10-06 |
20160289725 | HIGH-CELL DENSITY FED-BATCH FERMENTATION PROCESS FOR PRODUCING RECOMBINANT PROTEIN - Methods for producing proteins, for example, recombinant meningococcal 2086 proteins, using fed-batch fermentation with continuous input of an inducer after achieving a threshold parameter, and optionally continuous input of a carbon source, for example, a constant rate input, to improve protein yields, as well as high density protein compositions and compositions for use in the methods of the present invention, are provided. | 2016-10-06 |
20160289726 | METHOD OF PRODUCING GLYCOPROTEIN - Disclosed is a method of producing a glycoprotein, the method including the steps of: introducing a gene encoding a desired protein and a gene encoding an antibody that inhibits a decomposing enzyme preventing formation of a desired complex-type sugar chain in the desired protein into an insect organism or insect cells; and obtaining a desired protein having a desired complex-type sugar chain from the insect organism or insect cells obtained in the introduction step. | 2016-10-06 |
20160289727 | METHOD FOR OPTIMIZING THE ASSEMBLY AND PRODUCTION OF HETERO-MULTIMERIC PROTEIN COMPLEXES - Methods are provided to improve the expression of protein complexes by tuning the expression levels of each component required for the assembly of the complex. These methods are effective in limiting the expression of the dominant chain and, thus, equilibrating their relative abundance. The methods provided herein lead to a significant increase in productivity and final bispecific yields both in transient expression systems as well as in stably transfected mammalian cells. | 2016-10-06 |
20160289728 | METHOD FOR DETECTING FLUORESCENCE OR ABSORBANCE, METHOD FOR SUPPRESSING BACKGROUND, METHOD FOR MEASURING ADP, METHOD FOR MEASURING ACTIVITY OF ADP-SYNTHESIZING ENZYME, AND METHOD FOR MEASURING ACTIVITY OF GLUCOSYLTRANSFERASE - In a method for detecting fluorescence or absorbance of the present invention, a diaphorase causes reduction from resazurin to resorufin in the presence of an SH reagent and NADH or NADPH, and the resulting fluorescence intensity or absorbance is measured. A method for measuring ADP of the present invention includes a 2-1 process in which glucose is reacted with ADP and an ADP-dependent hexokinase, a 2-2 process in which the glucose-6-phosphate obtained in the 2-1 process is reacted with NAD or NADP and glucose-6-phosphate dehydrogenase, and a 2-3 process in which resazurin is reacted with the NADH or NADPH obtained in the 2-2 process and a diaphorase in the presence of an SH reagent, and the resulting fluorescence intensity or absorbance is measured. | 2016-10-06 |
20160289729 | INSTRUMENT AND SYSTEM FOR RAPID MICROORGANISM IDENTIFICATION AND ANTIMICROBIAL AGENT SUSCEPTIBILITY TESTING - A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing. | 2016-10-06 |
20160289730 | DETECTION, ISOLATION AND IDENTIFICATION OF MICROORGANISMS - A method of selectively identifying live microorganisms in a sample involves contacting a sample suspected of containing a live microorganism of interest with a biomolecular precursor labeled with a reactive chemical label. The live microorganism of interest is grown under conditions that promote selective growth of the microorganism to permit the microorganism to utilize the labeled biomolecular precursor to synthesize labeled biomolecules on a cell surface of the live microorganism. Labeled live microorganisms are contacted with a reporter and/or capture element bearing a functional group that reacts with the reactive chemical label. The labeled live microorganism is analyzed to identify it. The method can specifically isolate live microorganisms from dead ones thereby reducing the possibility of false identification of contaminating microorganisms and is able to detect specific strains using tailored metabolites that are specific for a given microorganism. The present method is considerably faster than currently used cell culture-based methods. | 2016-10-06 |
20160289731 | MEANS AND METHODS FOR DETERMINATION OF BOTULINUM NEUROTOXIN BIOLOGICAL ACTIVITY - The present invention is concerned with means and methods for determining neurotoxin activity. Specifically, it relates to a polynucleotide encoding a fusion polypeptide comprising (i) a transcription factor domain and (ii) a cytoplasmic retention domain, separated by a linker comprising a neurotoxin cleavage site and to a fusion polypeptide encoded by the polynucleotide of the invention. Also contemplated is a vector comprising the polynucleotide of the invention and a host cell comprising the polynucleotide, vector or fusion polypeptide of the invention. Moreover, envisaged is a method for determining neurotoxin activity in a sample. In addition, the invention pertains to the use of the polynucleotide, vector, fusion polypeptide or host cell of the invention for determining neurotoxin activity in a sample. Finally, the invention relates to a kit for determining neurotoxin activity comprising the polynucleotide, vector, fusion polypeptide or host cell of the invention. | 2016-10-06 |
20160289732 | WASH MONITOR AND METHOD OF USE - The present disclosure provides a monitoring device comprising a test composition, a test element comprising a test portion to which the test composition is releasably adhered, a detection reagent, and a container comprising a first end with an opening and a second end opposite the first end. The test composition comprises a predetermined quantity of tracer analyte. The container is configured to receive the test portion and configured to be operationally coupled to an analytical instrument. The tracer analyte and the detection reagent each are capable of participating in one or more chemical reaction that results in the formation of a detectable product. A method of using the monitoring device to assess the efficacy of a washing process is also provided. | 2016-10-06 |
20160289733 | REDUCED GRAPHENE OXIDE-BASED BIOSENSORS - The present application discloses a biosensor that comprises a nucleic acid probe absorbed on reduced graphene oxide, the nucleic acid probe comprising an RCA primer sequence linked to a recognition moiety for an analyte to be detected by the biosensor. | 2016-10-06 |
20160289734 | METHODS OF USING OLIGONUCLEOTIDE-GUIDED ARGONAUTE PROTEINS - The invention relates to the use of Argonaute polypeptide:guide molecule complexes as fast and specific nucleic acid probes, as specific, nucleic acid-guided restriction enzymes for DNA and RNA substrates, and as a means to detect RNA-protein interactions, RNA detection, DNA detection, and RNA depletion. Using such Argonaute polypeptide:guide molecule complexes enables fast and specific detection, purification, and enzymatic activity. | 2016-10-06 |
20160289736 | INDUCTION PCR - Methods, devices, and kits are provided for performing PCR and other thermal cycling reactions in <20 seconds per cycle, using induction heating. | 2016-10-06 |
20160289737 | PLURALITY OF TRANSPOSASE ADAPTERS FOR DNA MANIPULATIONS - The present invention relates to transposase adapters and uses thereof, including uses in preparing DNA molecules, in vitro amplification, sequencing of nucleic acids, and screening of DNA libraries for sequences of interest as well as nucleic acid delivery. | 2016-10-06 |
20160289738 | METHOD FOR ANALYSING THE INTERACTION OF NUCLEOTIDE SEQUENCES IN A THREE-DIMENSIONAL DNA STRUCTURE - The present invention provides a method for analysing the interaction of one or more nucleotide sequence(s) from one or more region(s) of interest with other nucleotides sequences in a three-dimensional DNA structure, comprising the steps of: (a) providing a sample of cross-linked DNA; (b) digesting the cross-linked DNA with a first restriction enzyme; (c) ligating the cross-linked nucleotide sequences; (d) reversing the cross-linking; e) fragmenting the ligation and ligated molecules from (d); (f) hybridising the fragments from (e) to one or more oligonucleotides representing the sequences which are adjacent to the cleavage site of the first restriction enzyme in order to enrich for the ends of the nucleotide sequences that have been ligated to another nucleotide sequence in step (c); and (g) analysing the nucleotide sequence of the enriched fragments in order to identify the nucleotide sequences involved in interaction(s). | 2016-10-06 |
20160289739 | PCR AMPLIFICATION METHODS AND KITS FOR DETECTING AND QUANTIFYING SULFATE-REDUCING BACTERIA - A kit for optional use with a PCR method of amplification may include at least one reaction well, and an internal amplification control for a PCR amplification of an APS reductase gene having a sequence complementary to at least one sequence essentially identical to SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, and mixtures thereof. The kit may be used with a PCR method of amplifying at least one sulfur-reducing bacteria extracted from an oilfield fluid. | 2016-10-06 |
20160289740 | METHODS AND COMPOSITIONS FOR COMBINATORIAL BARCODING - The present disclosure provide compositions, methods and kits for generating a set of combinatorial barcodes, and uses thereof for barcoding samples such as single cells or genomic DNA fragments. Some embodiments disclosed herein provide compositions comprising a set of component barcodes for producing a set of combinatorial barcodes. The set of component barcodes can comprise, for example, n×m unique component barcodes, wherein n and m are integers, each of the component barcodes comprises: one of n unique barcode subunit sequences; and one or two linker sequences or the complements thereof, wherein the component barcodes are configured to connect to each other through the one or two linker sequences or the complements thereof to produce a set of combinatorial barcodes. | 2016-10-06 |
20160289741 | DNA TEMPLATES FOR ROLLING CIRCLE AMPLIFICATION - The present application provides circular templates that are high in adenine and cytosine and methods and uses thereof for rolling circle amplification (RCA). These templates are particularly suitable for biosensing applications involving RCA. | 2016-10-06 |
20160289742 | SELECTIVE ENRICHMENT OF NUCLEIC ACIDS - Methods for the selective enrichment of nucleic acids. | 2016-10-06 |
20160289743 | DECALCIFICATION SOLUTION WITH PRESERVATION OF RNA - The present invention is directed to methods of decalcification and tissue sample preparation that allows for the reproducible quantitative analysis of gene expression in hard tissue samples like bone, mineralizing cartilage and tendon, dentin, cementum and/or enamel that are too hard to section effectively using conventional means. | 2016-10-06 |
20160289744 | SYSTEMS AND METHODS FOR ENHANCED SCODA - Methods and apparatus for separating, concentrating and/or detecting molecules based on differences in binding affinity to a probe are provided. The molecules may be differentially modified. The molecules may be differentially methylated nucleic acids. The methods can be used in fields such as epigenetics or oncology to selectively concentrate or detect the presence of specific biomolecules or differentially modified biomolecules, to provide diagnostics for disorders such as fetal genetic disorders, to detect biomarkers in cancer, organ failure, disease states, infection or the like. | 2016-10-06 |
20160289745 | NUCLEIC ACID ASSAY FOR DIAGNOSING OR MONITORING A PATHOGEN INFECTION IN A BODILY FLUID FROM A SUBJECT TREATED WITH AN ANTI-PATHOGENIC AGENT - Described herein is a method and assay of detecting the presence of a polynucleotide in a bodily fluid obtained from a subject treated with an anti-pathogenic agent comprising isolating the polynucleotide from a first and a second sample of a bodily fluid, amplifying the polynucleotide, and determining the polynucleotide, wherein the polynucleotide is a pathogen polynucleotide. Further provided is a method for diagnosing a pathogen infection in a subject, for detecting a pathogen infection in a subject treated with an anti-pathogenic agent, and for detecting the presence and/or genotype of a pathogen in a bodily fluid. | 2016-10-06 |
20160289746 | MULTIPLEX DIAGNOSTIC ASSAYS FOR LYME DISEASE AND OTHER TICK-BORNE DISEASES - The present invention provides novel methods of diagnosing and determining treatment strategies for Lyme disease and other tick-borne illnesses. | 2016-10-06 |
20160289747 | DETECTION OF NUCLEIC ACIDS BY STRAND INVASION BASED AMPLIFICATION - A method for detecting a target nucleic acid sequence in a sample in the presence of at least protein capable of binding to single-stranded DNA is provided, comprising contacting said sample with at least one oligonucleotide probe comprising a fluorophore, a quencher and a region complementary to said target nucleic acid sequence. The sequence of the oligonucleotide probe comprises at least 20% RNA nucleotides, modified RNA nucleotides and/or PNA nucleotides. | 2016-10-06 |
20160289748 | METHODS FOR DETECTING LEGIONELLA NUCLEIC ACIDS IN A SAMPLE - Methods for detecting | 2016-10-06 |
20160289749 | DOUBLE STRANDED LINEAR NUCLEIC ACID PROBE - A double-stranded nucleic acid hybridization probe and methods of using the same are described. The probe described is particularly suited for real-time RT-PCR reactions and has high tolerance to mismatches. | 2016-10-06 |
20160289750 | LOCALISED RCA-BASED AMPLIFICATION METHOD USING A PADLOCK-PROBE - The present invention provides a method for performing a localised RCA reaction comprising at least two rounds of RCA, wherein the product of a second RCA reaction is attached, and hence localised, to a product of a first RCA reaction, said method comprising: (a) providing a concatemeric first RCA product comprising repeated monomers; (b) directly or indirectly hybridising to monomers of said first RCA product a circularisable oligonucleotide comprising target-complementary 3′ and 5′ end regions such that the 3′ and 5′ ends of said oligonucleotide hybridise in juxtaposition for ligation directly or indirectly to each other, wherein the target is a sequence in a monomer of said first RCA product or an intermediate molecule hybridised thereto, and wherein the target-complementary end regions of said circularisable oligonucleotide are 6 to 16 nucleotides in length; (c) directly or indirectly ligating the ends of said circularisable oligonucleotide to circularise the oligonucleotide, thereby to provide a template for a second RCA reaction, wherein when said ends are indirectly ligated (i) either a gap oligonucleotide is provided which hybridises to the monomers of the first RCA product in between the 3′ and 5′ ends of the circularisable oligonucleotide such that it may be ligated to the respective ends, or the hybridised 3′ end of the circularisable oligonucleotide is extended by a polymerase such that the extended 3′ end may be ligated to the hybridised 5′ end, and (ii) the total length of the region of the second RCA template directly or indirectly hybridised to the monomers is no longer than 32 nucleotides in length; and (d) performing a second RCA reaction using said second RCA template of (c) and a primer for said second RCA, to form a second RCA product, wherein in said second RCA reaction the second RCA template remains attached to the first RCA product, and thereby the second RCA product is attached to the first RCA product. | 2016-10-06 |
20160289751 | MULTIPLEX AMPLIFICATION AND DETECTION - The invention relates to the field of multiplex amplification. In particular, the invention relates to methods for assaying a sample for one or more nucleic acid targets in a single reaction based on the distinct melting temperatures or melting profiles of primers and/or probes. The invention also provides probes and kits for use in such methods. | 2016-10-06 |
20160289752 | Method for the Isothermic Amplification of Nucleic Acid and SNP Detection - The invention relates to a novel buffer formulation that is able to reduce reaction time compared to conventional LAMP buffer and may be universally applied to other LAMP reactions with little optimization required. The invention also relates to a modified LAMP method making use of the novel buffer and may incorporate SNP-discriminating forward loop primers to enhance the LAMP reaction while also reducing the likelihood of false-positives. | 2016-10-06 |
20160289753 | Method for Evaluating Minority Variants in a Sample - A method of evaluating a sequence variation in a sample is provided. In some embodiments, the method may involve: amplifying a nucleic acid product from an initial sample; fragmenting an amount of the nucleic acid product to produce fragments; attaching an adaptor to each end of the fragments to produce adaptor-tagged fragments; sampling no more than 10% of the tagged fragments and amplifying them; sequencing at least some of the copies of the fragments to produce a plurality of sequence reads; grouping sequence reads for copies of fragments that have the same fragmentation breakpoints; deriving a consensus sequence for each of the read groups; and aligning the consensus sequences with a reference sequence. | 2016-10-06 |
20160289754 | Molecular Characterization Of Single Cells and Cell Populations For Non-Invasive Diagnostics - The invention discloses diagnostic techniques based on single cell genomics, consisting of obtaining a blood sample, enriching a sub-population of cells present in the blood sample, sequestering individual cells or group of cells from the blood sample, obtaining sequencing data from the sequestered cells or group of cells, using genetic variant information to determine the provenance of the cells, and genetically analyzing the cells of the correct provenance to provide a diagnostic readout. Using the cell-based testing techniques of the invention, the number of false positives is greatly reduced when compared to cell-free DNA (cfDNA) based traditional testing techniques. The invention may be effectively employed for non-invasive prenatal (NIPT) diagnostics, oncological testing and other diagnostic procedures. | 2016-10-06 |
20160289755 | DNA-ADAPTER-MOLECULES FOR THE PREPARATION OF DNA-LIBRARIES AND METHOD FOR PRODUCING THEM AND USE - The invention relates to DNA-adapter-molecules for the preparation of DNA-libraries and methods for producing them and their use. The invention is useful for the application in molecular biology, in particular for Next Generation Sequencing and/or Library Multiplexing. The present invention discloses DNA-adapter-molecules, comprising a double-stranded polynucleotide molecule, whereat the 5′ end of the first strand is modified in a way, that no binding site for kinases is available, the 3′ end of the first strand is modified in a way that no ligation can occur, the 5′ end of the reverse strand is modified in a way, that no binding site for a kinase is available, and the 3′ end of the reverse strand features a free hydroxyl group (at the 3′ position of the last nucleotide). | 2016-10-06 |
20160289756 | METHODS OF MACROMOLECULAR ANALYSIS USING NANOCHANNEL ARRAYS - Methods of analyzing features such as the physical size of macromolecules or biomarkers along large genomic DNA molecules were disclosed as wen as the devices for carrying out such high throughput analysis in a massively parallel fashion. Methods of fabricating such devices are also disclosed. | 2016-10-06 |
20160289757 | METHODS AND MATERIALS FOR DETECTING RNA SEQUENCES - The invention relates to a method for detecting RNA sequences. The invention also relates to nucleotide sequences, primers, probes and microarrays. | 2016-10-06 |
20160289758 | Compositions, Devices, Systems, and Methods for Using a Nanopore - Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof. | 2016-10-06 |
20160289759 | TREATMENT OF PYRROLINE-5-CARBOXYLATE REDUCTASE 1 (PYCR1) RELATED DISEASE BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO PYCR1 - The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Pyrroline-5-carboxylate reductase 1 (PYCR1), in particular, by targeting natural antisense polynucleotides of Pyrroline-5-carboxylate reductase 1 (PYCR1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of PYCR1. | 2016-10-06 |
20160289760 | T CELL RECEPTOR AND B CELL RECEPTOR REPERTOIRE ANALYSIS SYSTEM, AND USE OF SAME IN TREATMENT AND DIAGNOSIS - The repertoire of the variable region of T cell receptors (TCR) or B cell receptors (BCR) is quantitatively analyzed using non-biased gene sequence analysis. The present invention provides the following: a method for quantitatively analyzing the repertoire of the variable region of the T cell receptors (TCR) or B cell receptors (BCR) of a subject by using a database, wherein the method includes (1) a step for providing a nucleic acid sample containing the nucleic acid sequence of T cell receptors (TCR) or B cell receptors (BCR) amplified in a non-biased manner from the subject; (2) a step for determining the nucleic acid sequence contained in the nucleic acid sample; and (3) a step for calculating the frequency of appearance of each gene or combination thereof on the basis of the determined nucleic acid sequence and deriving the TCR or BCR repertoire of the subject. | 2016-10-06 |
20160289761 | OLIGONUCLEOTIDES COMPRISING A SECONDARY STRUCTURE AND USES THEREOF - There is provided a single stranded oligonucleotide having a 5′ end and a 3′ end, said oligonucleotide comprising a first and second section, the first section being positioned 5′ of the second section; and wherein (i) the first section is labelled with at least two detectable labels and is capable of hybridising to a target polynucleotide; and (ii) the second section is not capable of hybridising to a target polynucleotide; said second section comprising a stem-loop structure comprising a first portion, a second portion and a third portion and wherein the second portion is located between the first and third portions, and the first and third portions are complementary to each other. There is also provided a method of detecting the presence of a target polynucleotide and/or sequence variations within a target polynucleotide using such an oligonucleotide. | 2016-10-06 |
20160289762 | METHODS FOR PROFILIING AND QUANTITATING CELL-FREE RNA - The invention generally relates to methods for assessing a neurological disorder by characterizing circulating nucleic acids in a blood sample. According to certain embodiments, methods for assessing a neurological disorder include obtaining RNA present in a blood sample of a patient suspected of having a neurological disorder, determining a level of RNA present in the sample that is specific to brain tissue, comparing the sample level of RNA to a reference level of RNA specific to brain tissue, determining whether a difference exists between the sample level and the reference level, and indicating a neurological disorder if a difference is determined. | 2016-10-06 |
20160289763 | MICRO-RNAS THAT MODULATE LYMPHANGIOGENESIS AND INFLAMMATORY PATHWAYS IN LYMPHATIC VESSEL CELLS - The subject invention pertains to methods of identifying miRNAs that are differentially expressed in a lymphatic vessel cell under a proinflammatory stimulus. The invention also pertains to profiles of miRNAs that are differentially expressed in a lymphatic vessel cell under a proinflammatory stimulus and their use as biomarkers for diagnosis of inflammation mediated diseases. The current invention also provides therapeutic agents for the treatment of inflammation mediated lymphatic diseases wherein the therapeutic agents are capable of modulating the activity of the miRNAs differentially expressed in a lymphatic vessel cell under a proinflammatory stimulus. | 2016-10-06 |
20160289764 | METHODS AND KITS FOR DETECTING KAWASAKI DISEASE - Kits for detecting Kawasaki disease, containing an agent for sequencing or measuring the expression level of one or more of the following: miR-941, miR-182-5p and miR-183-5p are provided. Methods for detecting Kawasaki disease in a subject, comprising the identifying of one or more of the following in the subject: miR-941, miR-182-5p and miR-183-5p, are also provided. | 2016-10-06 |
20160289765 | BIOMARKERS FOR THE DIAGNOSIS OF LACUNAR STROKE - This invention provides gene expression profiles useful for diagnosing lacunar stroke and for distinguishing lacunar stroke from non-lacunar stroke. | 2016-10-06 |
20160289766 | MOLECULAR PROGNOSTIC SIGNATURE FOR PREDICTING BREAST CANCER METASTASIS, AND USES THEREOF - The present invention is based on the discovery of a unique 14-gene molecular prognostic signature that is useful for predicting breast cancer metastasis. In particular, the present invention relates to methods and reagents for detecting and profiling the expression levels of these genes, and methods of using the expression level information in predicting risk of breast cancer metastasis. | 2016-10-06 |
20160289767 | CHROMOSOMAL ASSESSMENT TO DIAGNOSE UROGENITAL MALIGNANCY IN DOGS - This invention is directed to a method of diagnosing bladder cancer in dogs. | 2016-10-06 |
20160289768 | DNA METHYLATION MARKERS ASSOCIATED WITH THE CpG ISLAND METHYLATOR PHENOTYPE (CIMP) IN HUMAN COLORECTAL CANCER - Particular aspects confirm the existence of a CpG island methylator phenotype (CIMP) in colorectal cancer, and provide novel validated DNA methylation markers associated with CIMP. Additional aspects provide novel methods and compositions for: determining CIMP status in colorectal cancers, determining the relationship between CIMP status and other molecular features of the cancers (e.g., BRAF mutation, KRAS mutation, and MSI status); determining the relationship between CIMP status and other variables (e.g., age, sex, tumor location, family history, race, country of origin, tumor characteristics (including, tumor type, tumor grade, invasive margin characteristics, lymphocyte infiltration characteristics, direct spread, lymph node spread, venous spread, and type of residual adjacent polyp, if present)); and determining, between subgroups defined by CIMP status and BRAF mutations, effects of selected risk factors (e.g., body mass index, smoking history, alcohol intake, dietary folate intake, folate metabolic enzyme polymorphisms, and history of hormonal use). | 2016-10-06 |
20160289769 | Methods for Combining Single Cell Profiling with Combinatorial Nanoparticle Conjugate Library Screening and In Vivo Diagnostic System - Methods for characterizing a cell employ a library of nanoparticle conjugates of one or more types, each type of nanoparticle conjugate comprising a nanoparticle, targeting entities of one or more types, and tags of one or more types, to determine the genotype and phenotype of a cell as well as other characteristics. The tags can include oligonucleotide barcodes. | 2016-10-06 |
20160289770 | MARKERS ASSOCIATED WITH HUMAN DOUBLE MINUTE 2 INHIBITORS - The invention provides methods of monitoring differential gene expression of biomarkers to determine patient sensitivity to Human Double Minute inhibitors (MDM2i), methods of determining the sensitivity of a cell to an MDM2i by measuring biomarkers and methods of screening for candidate MDM2i. | 2016-10-06 |
20160289771 | PLASMA MICRORNAS FOR THE DETECTION OF EARLY COLORECTAL CANCER - The present invention relates in general to the field of colorectal cancer detection, and more particularly, to plasma microRNAs for the detection of early colorectal cancer. Specifically, the present invention includes methods, kits and biomarkers for diagnosing or detecting colorectal neoplasia in a human subject comprising the steps of: A method for diagnosing or detecting colorectal neoplasia in a human subject comprising the steps of: obtaining one or more biological samples from the subject suspected of suffering from colorectal neoplasia; measuring an overall expression pattern or level of one or more microRNAs obtained from the one or more biological samples of the subject; and comparing the overall expression pattern of the one or more microRNAs from the biological sample of the subject suspected of suffering from colorectal neoplasia with the overall expression pattern of the one or more microRNAs from a biological sample of a normal subject, wherein the normal subject is a healthy subject not suffering from colorectal neoplasia, wherein overexpression of a combination of miR19a and miR19b, or miR19a and miR19b and miR15b is indicative of colorectal cancer. | 2016-10-06 |
20160289772 | Mitochondrial DNA deletion between about residues 12317-16254 for use in the detection of cancer - The present invention relates to methods for predicting, diagnosing and monitoring cancer. The methods comprise obtaining biological samples, extracting mitochondrial DNA (mtDNA) from the samples, quantifying mitochondrial DNA mutation in the sample and comparing the level of mtDNA mutation with a reference value. The methods of the invention may also be effective in screening for new therapeutic agents and treatment regimes, and may also be useful for monitoring the response of a subject to a preventative or therapeutic treatment. | 2016-10-06 |
20160289773 | DETECTION AND MONITORING OF RESISTANCE TO AN IMIDAZOTHIAZOLE ANTI-HELMINTHIC IN NEMATODES - The present disclosure concerns the determination of the resistance or the susceptibility of a nematode to an imidazothiazole anti-helmintic based on the assessment of the presence of an indel in the Hco-acr-8 gene (or the Hco-acr-8 gene ortholog). The present disclosure also provides tools and commercial packages for making such assessment. | 2016-10-06 |
20160289774 | A MOLECULAR MARKER OF PLASMODIUM FALCIPARUM ARTEMISININ RESISTANCE - K13-propeller polymorphism is a useful molecular marker for tracking the emergence and spread of ART-resistant | 2016-10-06 |
20160289775 | BIOSENSOR SYSTEM FOR THE RAPID DETECTION OF ANALYTES - A system, device, and method for rapid detection of analytes that includes a living, engineered biosensor cell that is typically a component of the mammalian immune system; a reporter protein that is engineered into and expressed by the living, engineered biosensor cell, wherein the reporter protein emits a detectable signal in response to certain predetermined changes in the cytosol of the living, engineered cell; a signal transduction pathway expressed by the living, engineered biosensor cell, wherein the signal transduction pathway controls a biological process within the cytosol of the living, engineered biosensor cell, and wherein the biochemical process, when it occurs, causes the reporter protein to emit a detectable signal; at least one type of detector molecule that is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule that is specific to that analyte; a plurality of non-antibody signal transducing elements that are either expressed by the living, engineered biosensor cell or that actively bind to a receptor or a receptor component expressed by the living, engineered biosensor cell, wherein each signal transducing element is adapted to receive a detector molecule. | 2016-10-06 |
20160289776 | Sensors For The Detection Of Intracellular Metabolites - The present invention relates to a cell which is genetically modified with respect to its wild type and which comprises a gene sequence coding for an autofluorescent protein, wherein the expression of the autofluorescent protein depends on the intracellular concentration of a particular metabolite. | 2016-10-06 |
20160289777 | PRIMERS AND PROBES FOR DETECTION AND DISCRIMINATION OF TYPES AND SUBTYPES OF INFLUENZA VIRUSES - Methods of detecting influenza, including differentiating between type and subtype are disclosed, for example to detect, type, and/or subtype an influenza infection. A sample suspected of containing a nucleic acid of an influenza virus, is screened for the presence or absence of that nucleic acid. The presence of the influenza virus nucleic acid indicates the presence of influenza virus. Determining whether the influenza virus nucleic acid is present in the sample can be accomplished by detecting hybridization between an influenza specific probe, influenza type specific probe, and/or subtype specific probe and an influenza nucleic acid. Probes and primers for the detection, typing and/or subtyping of influenza virus are also disclosed. Kits and arrays that contain the disclosed probes and/or primers also are disclosed. | 2016-10-06 |
20160289778 | HCV GENOTYPING ALGORITHM - The present invention relates to methods for determining genotypes of pathogens present in a sample, e.g. a clinical sample, using next generation sequencing, in particular ion semiconductor sequencing. The present invention also relates to apparatus comprising computer units for carrying out the genotyping methods disclosed herein as well as to software products suitable for the execution of the methods disclosed herein. | 2016-10-06 |
20160289779 | MONOAZO DYES WITH CYCLIC AMINE AS FLUORESCENCE QUENCHERS - The present disclosure provides reactive quencher dyes that can be used in the detection and/or quantification of desirable target molecules, such as proteins, nucleic acids and various cellular organelles. These dyes are essentially non-fluorescent but are efficient quenchers of various fluorescent dyes. Also, provided are methods of using the dyes, bio-probes incorporating dyes and methods of using the bio-probes. The quencher dyes described herein are modified to provide beneficial properties. | 2016-10-06 |
20160289780 | METHODS FOR ENERGY-EFFICIENT HIGH SOLIDS LIQUEFACTION OF BIOMASS - The present disclosure is generally related a method for the liquefaction of high-solids biomass substrates. Particularly, biomass can be added to a reactor until a pressure drop, measured inline, reaches the maximum system limitations. A commercial enzyme mixture (specific for the particular type of biomass to be processed) may then be added to the biomass, forming a slurry. The pressure may be continuously monitored and when the pressure drop reaches a steady state (which can be determined by little or no change in pressure drop for several minutes), more biomass may then be added until the high pressure limit of the pump system is reached again. The method can be repeated until the desired quantity of biomass is processed. | 2016-10-06 |
20160289781 | Strain of marine oil-degrading bacteria, compounds obtained by fermentation and their applications - A strain of marine oil degrading bacteria, compounds obtained by fermentation and their uses are published. The name is | 2016-10-06 |
20160289782 | BIOREFINERY SYSTEM, METHODS AND COMPOSITIONS THEREOF - The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C | 2016-10-06 |
20160289783 | Method For Treating Desulfurization Slag - The invention relates to a method for treating desulfurization slag, in which desulfurization slag from pig iron desulfurization is conveyed to a suitable unit in which the desulfurization slag is melted at a temperature of at least 1,400° C., said unit assuring a thorough mixing, and the treatment takes place in the unit under slightly oxidizing conditions, with the SO | 2016-10-06 |
20160289784 | HIGH-STRENGTH STEEL SHEET AND METHOD FOR MANUFACTURING THE SAME - A high-strength steel sheet and a method for manufacturing a high-strength steel sheet having excellent phosphatability and excellent corrosion resistance after electrodeposition coating has been performed, even in the case where the contents of Si and Mn are high. The method may comprise annealing a steal sheet by using a continuous annealing method, performing a heating process, controlling the maximum end-point temperature of a steel sheet in the annealing furnace, controlling the traveling time of the steel sheet, and controlling the dew point of the atmosphere. | 2016-10-06 |
20160289785 | MANUFACTURING METHOD OF MECHANICAL COMPONENT USING MARTENSITICSTAINLESS STEEL, ROTATING DEVICE, ROLLING BEARING AND ROLLING BEARING UNIT - A martensitic stainless steel containing, by mass %, C: 0.20% to 0.40%, N: 0.1% or less, Mo: 3% or less, and Cr: 12.0% to 16.0%, such that 0.3%≦C+N≦0.4% and a PI value (=Cr+3.3Mo+16N) is 18 or more, with the remainder being substantially Fe and unavoidable impurities is quenched from a temperature of 1,030° C. to 1,140° C. and subjected to a subzero treatment and tempering so as to obtain a prior austenite crystal grain size of a surface layer of 30 μm to 100 μm and a surface hardness of 58 HRc to 62 HRc. | 2016-10-06 |
20160289786 | FERRITE-MARTENSITE DUAL-PHASE STAINLESS STEEL AND METHOD OF MANUFACTURING THE SAME - A ferrite-martensite dual-phase stainless steel has satisfactory corrosion resistance and workability for a material for the body of a freight car and excellent low-temperature toughness. The ferrite-martensite dual-phase stainless steel has a specified chemical composition, in which inequalities (I) and (II) below are satisfied, and a steel microstructure including a dual phase of a ferrite phase and a martensite phase, in which the content of the martensite phase is 5% or more and 95% or less in terms of vol. %: | 2016-10-06 |
20160289787 | HIGH-CARBON STEEL SHEET AND METHOD OF MANUFACTURING THE SAME - A high-carbon steel sheet has a chemical composition represented by, in mass %, C: 0.60% to 0.90%, Mn: 0.30% to 1.50%, and Cr: 0.20% to 1.00%, and others, and has a structure represented by a concentration of Mn contained in cementite: 2% or more and 8% or less, a concentration of Cr contained in cementite: 2% or more and 8% or less, an average grain diameter of ferrite: 10 μm or more and 50 μm or less, an average particle diameter of cementite: 0.3 μm or more and 1.5 μm or less, and a spheroidized ratio of cementite: 85% or more. | 2016-10-06 |
20160289788 | HOT-ROLLED STEEL SHEET AND METHOD OF MANUFACTURING THE SAME - A hot-rolled steel sheet has a chemical composition containing, by mass %, C: 0.030% or more and 0.120% or less, Si: 0.05% or more and 0.50% or less, Mn: 1.00% or more and 2.20% or less, P: 0.025% or less, S: 0.0050% or less, N: 0.0060% or less, Al: 0.005% or more and 0.100% or less, Nb: 0.020% or more and 0.100% or less, Mo: 0.05% or more and 0.50% or less, Ti: 0.001% or more and 0.100% or less, Cr: 0.05% or more and 0.50% or less, Ca: 0.0005% or more and 0.0050% or less, and the balance being Fe and inevitable impurities, and has a microstructure including bainitic ferrite as a main phase and martensite and retained austenite as second phases, wherein a volume fraction of the main phase is 90% or more, an average grain diameter of the main phase is 10 μm or less, a volume fraction of the martensite is 0.5% or more and 9.5% or less, and a volume fraction of the retained austenite is 0.5% or more and 9.5% or less, wherein the steel sheet has a yield ratio of 90% or less, a yield strength of 555 MPa or more, and a tensile strength of 650 MPa or more. | 2016-10-06 |
20160289789 | SENSORS - Embodiments of the present invention provide an electromagnetic sensor ( | 2016-10-06 |
20160289790 | SELECTIVE REGENERATION OF ISOTOPE-SPECIFIC MEDIA RESINS IN SYSTEMS FOR SEPARATION OF RADIOACTIVE ISOTOPES FROM LIQUID WASTE MATERIALS - Processes, systems, and methods for selectively regenerating an ion exchange resin generally comprises washing the ion exchange resin with an elution agent that encourages only selected contaminants, and especially selected radioactive isotopes, to disengage or decouple from the resin and enter solution in the elution agent, which thereafter is identified as the elution agent solution. The elution agent solution is then passed through a column of isotope-specific media (ISM). When the selected radioactive isotopes within the elution agent solution come into contact with the constituent media isotopes of the ISM, the selected radioactive isotopes are retained on the reactive surface areas of the ISM or within the interstitial spaces of the porous structures of the constituent media isotopes of the ISM. In some embodiments, the constituent media isotopes of the ISM are embedded, impregnated, or coated with the specific radioactive isotope that the particular ISM are adapted to separate. | 2016-10-06 |
20160289791 | DERIVING HIGH VALUE PRODUCTS FROM WASTE RED MUD - Disclosed herein, is a process for recovering- valuable metals and/or their oxides from red mud bauxite residues or similar. The process comprises: calcining a red mud residue having a pH of less than about 10 to provide a calcinated red mud residue; acid leaching the calcinated red mud residue to provide a silica rich solid component and an acid leachate; separating the silica rich solid component and the acid leachate; precipitating an iron rich solid component from the acid leachate; and separating the precipitated iron rich solid component from the acid leachate to provide an aluminium rich liquor. | 2016-10-06 |
20160289792 | COMPOSITION OF A FILTER CAKE FOR PRECIOUS METALS RECOVERY - A process is provided for preparing a spent noble metal fixed-bed catalyst for precious metals recovery, comprising: a) adding the catalyst to a caustic solution to wash the spent catalyst and to make a wash slurry having an alkaline pH, wherein the spent catalyst has been in contact with chloroaluminate ionic liquid catalyst, and wherein the spent catalyst comprises from 5 to 35 wt % chloride; and b) filtering the wash slurry and collecting: i) a filter cake having from at least 70 wt % of the chloride in the spent catalyst removed and having the noble metals retained, and ii) a wash filtrate. Also provided is a filter cake comprising a washed consolidated cake having 40 to 75 wt % solids, a cake moisture content from 25 to less than 60 wt %, 0.1 to 1.5 wt % total noble metals, and a residual chloride content of from zero to less than 4 wt %. | 2016-10-06 |
20160289793 | METHOD FOR LEACHING RECOVERY-BOILER ASH - A method to be used in conjunction with a single-stage or multi-stage process for leaching ash originating from the recovery boiler of a pulp mill, particularly when the ash contains a significant amount of carbonate, wherein calcium compounds, such as calcium oxide (CaO) or calcium hydroxide (Ca(OH) | 2016-10-06 |
20160289794 | CATION ADSORBENT AND TREATMENT METHOD FOR SOLUTION USING THE SAME - A cation adsorbent of an embodiment includes tungsten oxide particles having a BET specific surface area in a range of 0.82 m | 2016-10-06 |
20160289795 | Systems and Processes for Recovering Scandium Values From Laterite Ores - A method is provided for extracting scandium values from a scandium bearing laterite ore. The method includes providing a portion of a scandium bearing laterite ore having an average particle size of no more than 200 mesh, leaching the ore to produce a leachate, and recovering scandium values from the leachate. | 2016-10-06 |
20160289796 | USE OF AN ORGANIC-INORGANIC HYBRID MATERIAL FOR EXTRACTING URANIUM(VI) FROM A SULFURIC ACID AQUEOUS SOLUTION, ISSUED NOTABLY FROM THE SULFURIC LEACHING OF A URANIUM-BEARING ORE - The invention relates to the use of an organic-inorganic hybrid material, comprising an inorganic solid support on which are grafted organic molecules having the general formula (I) below: | 2016-10-06 |
20160289797 | COPPER-ZINC ALLOY, BAND MATERIAL COMPOSED THEREOF, PROCESS FOR PRODUCING A SEMIFINISHED PART COMPOSED OF A COPPER-ZINC ALLOY AND SLIDING ELEMENT COMPOSED OF A COPPER-ZINC ALLOY - A copper-zinc alloy having the following composition (in % by weight):
| 2016-10-06 |
20160289798 | ACID AND ALKALI RESISTANT NICKEL-CHROMIUM-MOLYBDENUM-COPPER ALLOYS - A nickel-chromium-molybdenum-copper alloy resistant to 70% sulfuric acid at 93° C. and 50% sodium hydroxide at 121° C. for acid and alkali neutralization in the field of waste management; the alloy contains, in weight percent, 27 to 33 chromium, 4.9 to 7.8 molybdenum, greater than 3.1 but no more than 6.0 copper, up to 3.0 iron, 0.3 to 1.0 manganese, 0.1 to 0.5 aluminum, 0.1 to 0.8 silicon, 0.01 to 0.11 carbon, up to 0.13 nitrogen, up to 0.05 magnesium, up to 0.05 rare earth elements, with a balance of nickel and impurities. | 2016-10-06 |
20160289799 | Acid and Alkali Resistant Ni-Cr-Mo-Cu Alloys with Critical Contents of Chromium and Copper - A nickel-chromium-molybdenum-copper alloy resistant to 70% sulfuric acid at 93° C. and 50% sodium hydroxide at 121° C. for acid and alkali neutralization in the field of waste management; the alloy contains, in weight percent, 27 to 33 chromium, 4.9 to 7.8 molybdenum, 3.1 to 6.0 wt. % copper (when chromium is between 30 and 33 wt. %) or 4.7 to 6.0 wt. % copper (when chromium is between 27 and 29.9 wt. %), up to 3.0 iron, 0.3 to 1.0 manganese, 0.1 to 0.5 aluminum, 0.1 to 0.8 silicon, 0.01 to 0.11 carbon, up to 0.13 nitrogen, up to 0.05 magnesium, up to 0.05 rare earth elements, with a balance of nickel and impurities. Titanium or another MC carbide former can be added to enhance thermal stability of the alloy. | 2016-10-06 |
20160289800 | COBALT ALLOYS - Alloys, processes for preparing the alloys, and manufactured articles including the alloys are described. The alloys include, by weight, about 10% to about 20% chromium, about 4% to about 7% titanium, about 1% to about 3% vanadium, 0% to about 10% iron, less than about 7% nickel, 0% to about 10% tungsten, less than about 3% molybdenum, and the balance of weight percent including cobalt and incidental elements and impurities. | 2016-10-06 |
20160289801 | HIGH-PURITY ALUMINIUM GRAIN MATERIAL AND METHOD FOR PRODUCING THE SAME - An object of the present invention is to provide an aluminium grain material having significantly high purity, and a method for producing the same. Disclosed is an aluminium grain material having an average mass per grain of 0.01 to 10 g, wherein the total content of twelve elements of silicon (Si), iron (Fe), copper (Cu), magnesium (Mg), titanium (Ti), vanadium (V), chromium (Cr), manganese (Mn), nickel (Ni), zinc (Zn), gallium (Ga), and zirconium (Zr) in the aluminium grain material, measured by glow discharge mass spectrometry, is 5 ppm by mass or less. | 2016-10-06 |
20160289802 | ALUMINUM ALLOY - In a first aspect, the invention provides aluminum alloy comprising the following composition, all values in weight %: Si 0.25-1.5 Cu 0.3-1.5 Fe up to 0.5 Mn up to 0.1 all other elements including Mg being incidental and present (if at all) then in an amount less than or equal to 0.05 individually, and less than or equal to 0.15 in aggregate, the balance being aluminum. In a second aspect, the invention provides a composite aluminum sheet product comprising a core layer and at least one clad layer wherein the at least one clad layer is an aluminum alloy comprising the following composition, all values in weight %: Si 0.25-1.5 Cu 0.3-1.5 Fe up to 0.5 Mn up to 0.1 all other elements including Mg being incidental and present (if at all) then in an amount less than or equal to 0.05 individually, and less than or equal to 0.15 in aggregate, the balance being aluminum. In a third aspect, the invention provides a method of making a joined structure of a steel component and an aluminum component made from the alloy and/or the sheet product of the invention. | 2016-10-06 |
20160289803 | FINE-GRAINED HIGH CARBIDE CAST IRON ALLOYS - Embodiments of alloys having high, fine-grained carbide content, and methods of manufacturing such alloys. The alloys can be determined through the use of thermodynamic, microstructural, and compositional criterial in order to create a high strength and high toughness alloy. In some embodiments, the alloys can be used as a wear resistant component. | 2016-10-06 |
20160289804 | SINTERED ALLOY AND PRODUCTION METHOD THEREFOR - A sintered alloy having superior heat resistance and superior wear resistance and also having corrosion resistance against salt damage that may occur in cold-weather regions, and a production method therefor, are provided. The sintered alloy consists of, by mass %, 32.4 to 48.4% of Cr, 2.9 to 10.0% of Mo, 0.9 to 2.9% of Si, 0.3 to 1.8% of P, 0.7 to 3.9% of C, and the balance of Fe and inevitable impurities, and it has a density ratio of not less than 90% and includes carbides that are dispersed in a matrix of a metallic structure thereof. | 2016-10-06 |
20160289805 | MARTENSITIC STAINLESS STEEL, PART MADE IN SAID STEEL AND METHOD FOR MANUFACTURING SAME - A martensitic stainless steel is provided, wherein its composition is:
| 2016-10-06 |
20160289806 | CU-NI-SI BASED ROLLED COPPER ALLOY AND PRODUCTION METHOD THEREOF - To provide a Cu—Ni—Si based rolled copper alloy having excellent strength, electric conductivity and fatigue properties, disclosed is a Cu—Ni—Si based rolled copper alloy, comprising: a total amount of 3.0 to 4.5% by mass of at least one or more selected from the group consisting of Ni and Co, 0.6 to 1.0% by mass of Si, and the balance Cu and inevitable impurities, wherein a 0.2% yield strength YS in a direction transverse to rolling direction is 1040 MPa or more. | 2016-10-06 |
20160289807 | HARDENING NICKEL-CHROMIUM-IRON-TITANIUM-ALUMINIUM ALLOY WITH GOOD WEAR RESISTANCE, CREEP STRENGTH, CORROSION RESISTANCE AND PROCESSABILITY - Age-hardening nickel-chromium-iron-titanium-aluminum wrought alloy with very good wear resistance and at the same time good creep strength, good high-temperature corrosion resistance and good processability, with (in mass-%)>18 to 26% chromium, 1.5 to 3.0% titanium, 0.6 to 2.0% aluminum, 7.0 to 40% iron, 0.005 to 0.10% carbon, 0.0005 to 0.050% nitrogen, 0.0005 to 0.030% phosphorus, max. 0.010% sulfur, max. 0.020% oxygen, max. 0.70% silicon, max. 2.0% manganese, max. 0.05% magnesium, max. 0.05% calcium, max. 0.5% molybdenum, max. 0.5% tungsten, max. 0.2% niobium, max. 0.5% copper, max. 0.5% vanadium, if necessary 0 to 15% Co, if necessary 0 to 0.20% Zr, if necessary 0.0001 to 0.008% boron, wherein optionally the following elements may also be contained in the alloy: Y 0-0.20% and/or La 0-0.20% and/or Ce 0-0.20% and/or Ce mixed metal 0-0.20% and/or Hf 0-0.20% and/or Ta 0-0.60%, remainder nickel and the usual unavoidable impurities, wherein the relationship Cr+Fe+Co≧25% must be satisfied in order to achieve good processability and the relationship fh≧0 with fh=6.49+3.88 Ti+1.36 Al−0.301 Fe+(0.759−0.0209 Co)Co−0.428Cr−28.2C, has to be satisfied in order that an adequate strength is achieved at higher temperatures, wherein Ti, Al, Fe, Co, Cr and C are the concentrations of the elements in question in mass-% and fh is expressed in %. | 2016-10-06 |
20160289808 | METHOD FOR PROCESSING A DISPERSION-HARDENED PLATINUM COMPOSITION - A method for processing a dispersion-hardened platinum composition is provided. A three-dimensional body of a dispersion-hardened platinum composition containing at least 70% by weight platinum and maximally 29.95% by weight other precious metals, as well as 0.05% by weight to 0.5% by weight of at least one partially-oxidized non-precious metal selected from zirconium, cerium, scandium, and yttrium is provided and cold formed, whereby the cross-sectional area of the three-dimensional body is reduced by maximally 20% during the cold forming, Subsequently a temperature treatment is performed on the cold-formed three-dimensional body, in which the cold-formed product is tempered at at least 1,100° C. for at least one hour. A method for producing a product made of a dispersion-hardened platinum composition, a dispersion-hardened platinum material obtained according to the processing method, and the use of a dispersion-hardened platinum material are also described. | 2016-10-06 |
20160289809 | STEEL FOR HOT FORMING - A steel for hot forming. The steel for hot forming has the following composition in weight%: C: 0.10-0.25, Mn: 1.4-2.6, Si:<0.4, Cr:<1.0, Al:<1.5, P:<0.02, S:<0.005, N:<0.03, B:<0.0004, 0:<0.008 and optionally: Ti:<0.3, Mo:<0.5, Nb:<0.3, V:<0.5, Ca:<0.05, the remainder being iron and unavoidable impurities. Also disclosed is a strip, sheet or blank produced with such a steel, a method for producing a hot formed product, such a product and the use thereof | 2016-10-06 |
20160289810 | Highly Durable Superhydrophobic, Oleophobic and Anti-Icing Coatings and Methods and Compositions for Their Preparation - Highly durable hydrophobic, oleophobic, and anti-icing coatings and methods of their preparation and use are described herein. | 2016-10-06 |
20160289811 | VACUUM PLASMA SPRAYED COATING INCLUDING OXIDE DISPERSIONS - A technique may include controlling a vacuum pump to evacuate a vacuum chamber to high vacuum; controlling a plasma spray device to deposit a coating on a substrate in the vacuum chamber using plasma spray physical vapor deposition; and controlling a source of a reactive gaseous species to introduce a controlled amount of the reactive gaseous species into the vacuum chamber during the plasma spray physical vapor deposition process. The reactive gaseous species may react with at least one constituent of the coating to form a dispersed phase in at least part of the coating. | 2016-10-06 |
20160289812 | PROCESS FOR MANUFACTURING HIGH-NITROGEN STAINLESS STEEL PIPE WITH HIGH STRENGTH, HIGH DUCTILITY, AND EXCELLENT CORROSION AND HEAT RESISTANCE - A process for manufacturing a high nitrogen stainless steel pipe material includes keeping an outside surface and/or an inside surface of an austenite stainless steel pipe material in contact with a substance that becomes a nitrogen (N) source, heating the steel pipe together with the nitrogen source substance at a temperature of 800° C. to 1100° C. in a range of temperatures not higher than the critical temperature for crystal grain enlargement of the steel pipe material to cause nitrogen to be absorbed into the surface of the pipe and diffused into the steel solid phase, and applying to the heat-treated pipe material annealing treatment in the range of temperatures in vacuum, inert gas including argon gas or an atmosphere of a gas with a reducing substance including H | 2016-10-06 |
20160289813 | METHOD FOR MANUFACURING AMORPHOUS ALLOY FILM AND METHOD FOR MANUFACTURING NANOSTRUCTURED FILM COMPRISING NITORGEN - The purpose of the present invention is to provide a nanostructured composite thin film showing low friction properties and a method for manufacturing same, and a member with low friction properties and a method for manufacturing same, wherein the thin film shows an exceptionally low value of friction coefficient but also shows high hardness and adhesion in comparison with conventional thin films, and the member has such a nanostructured composite thin film formed on the surface thereof. Provided, according to one aspect of the present invention, is a nanostructured composite thin film having low friction properties which has a composite structure in which a nitride phase comprising Zr and Al as a nitride component and at least one metallic phase are mixed, and has the size of a crystal grain in the range of 5 nm to 30 nm. Here, the nitride phase has a crystal structure of Zr nitride, and the metallic phase can comprise one or more selected from Cu and Ni. | 2016-10-06 |
20160289814 | DEPOSITION APPARATUS - A deposition apparatus includes a chamber maintaining a vacuum atmosphere, a deposition material container within the chamber, the deposition material container containing a deposition material, a substrate fixing part that faces the deposition material container to fix a substrate, a mask fixing part on a first surface of the substrate, the mask fixing part including a plurality of magnets on the first surface of the substrate, a driving cam unit that reciprocates along a first direction, a following cam unit that reciprocates in a second direction crossing the first direction in accordance with a reciprocation direction of the driving cam unit, and a driving motor to supply a predetermined power to the driving cam unit, and a mask on a second surface of the substrate attachable to the substrate by a magnetic force of the plurality of magnets. | 2016-10-06 |
20160289815 | METHOD AND APPARATUS FOR DEPOSITING A MATERIAL - A method is for depositing a dielectric material on to a substrate in a chamber by pulsed DC magnetron sputtering with a pulsed DC magnetron device which produces one or more primary magnetic fields. In the method, a sputtering material is sputtered from a target, wherein the target and the substrate are separated by a gap in the range 2.5 to 10 cm and a secondary magnetic field is produced within the chamber which causes a plasma produced by the pulsed DC magnetron device to expand towards one or more walls of the chamber. | 2016-10-06 |
20160289816 | ELECTROMAGNETIC SHIELD - There is provided an inexpensive electromagnetic shield that can achieve exceptional shielding and display visibility characteristics, and provide high environmental resistance as necessary. In an electromagnetic shield ( | 2016-10-06 |
20160289817 | THIN-FILM DEPOSITION METHODS WITH FLUID-ASSISTED THERMAL MANAGEMENT OF EVAPORATION SOURCES - In various embodiments, evaporation sources are heated and/or cooled via a fluid-based thermal management system during deposition of thin films. | 2016-10-06 |
20160289818 | Laminate Structure And Manufacturing Method Thereof - A laminate structure having an indium target with the occurrence of defects being well controlled and excellent in adhesion between the indium target and a backing tube is provided. A laminate structure of an indium target and a backing tube wherein a defect area ratio at an indium-backing tube interface is 5.0% or less. | 2016-10-06 |
20160289819 | HYDROXIDE FACILITATED OPTICAL FILMS - Methods of lowering the absorption losses of optical coatings at wavelengths shorter than 350 nm. During a deposition process of a metal oxide optical coating, dissociated hydroxide ion is added to the deposition process. The hydroxide ion source can be, for example, water vapor. By adding the hydroxide ion, a decrease in impurities and defects/dislocations in the optical coating is achieved. | 2016-10-06 |