40th week of 2016 patent applcation highlights part 43 |
Patent application number | Title | Published |
20160290922 | Low Energy Laser Spectroscopy - In a spectrophotometer and a method of operation, very low levels of energy are produced in a laser diode and directed to excite a sample. Energy is provided to a quantum well to bring the laser diode to a pre-lasing state. Another increment of energy causes the laser diode to emit energy at an energy level lower than a visible laser beam. The energy produced by the laser is collided with the sample. A stimulated emission from the sample includes signals from various entities in the sample. The return emission spectra from the sample comprise signatures used to identify compounds. Use of such very low energies collided with a sample elicit spectra not previously associated with respective analytes. A Raman spectroscopy platform is used for performance of the method. | 2016-10-06 |
20160290923 | Method for determining a scale inhibitor concentration in a sample - The invention relates to a method for determining a scale inhibitor concentration in a sample comprising at least a first scale inhibitor, which is a synthetic organic compound comprising at least one ionised group. The method comprises optionally diluting and/or purifying the sample, and allowing the sample to interact with a reagent comprising a lanthanide(III) ion. The sample is excited at a first excitation wavelength and a sample signal deriving from the lanthanide(III) ion is detected at a signal wavelength by using time-resolved luminescence measurement, and the concentration of the at least first scale inhibitor in the sample is determined by using the detected sample signal. | 2016-10-06 |
20160290924 | Method for analysing a sample comprising at least a first and a second scale inhibitor - The invention relates to a method for analysing a sample comprising at least a first and a second scale inhibitor, which scale inhibitors are synthetic organic compounds comprising at least one ionised group. The method comprises optionally diluting and/or purifying the sample, and allowing the sample interact with a reagent comprising lanthanide(III) ion. The sample is excited at a first excitation wavelength and a sample signal deriving from the lanthanide(III) ion is detected at a signal wavelength by using time-resolved luminescence measurement. The total concentration of the first and the second scale inhibitor is determined by using the detected sample signal, and the concentration of the first scale inhibitor in the sample is determined. The concentration of the second scale inhibitor is determined mathematically by using the obtained results for the total concentration and for the first scale inhibitor concentration. | 2016-10-06 |
20160290925 | APPARATUS AND METHOD FOR FLUORESCENCE GRADING OF GEMSTONES - Provided herein is an apparatus for assessing a fluorescence characteristic of a gemstone. The apparatus comprises an optically opaque platform for supporting a gemstone to be assessed, one or more light source to provide uniform UV and non-UV illumination, an image capturing component, and a telecentric lens positioned to provide fluorescent images of the illuminated gemstone to the image capturing component. Also provided are methods of fluorescence analysis based on images collected using such an apparatus. | 2016-10-06 |
20160290926 | MEASUREMENT OF TISSUE STRUCTURES - The disclosure relates to measurement and classification of tissue structures in samples using a combination of light imaging and spectroscopy, in particular although not necessarily exclusively for detection of tumours such as basal cell carcinoma or breast tumours in tissue samples. Embodiments disclosed include a method of automatically identifying tissue structures in a sample, the method comprising the steps of: measuring ( | 2016-10-06 |
20160290927 | OPTICAL METROLOGY SYSTEM FOR SPECTRAL IMAGING OF A SAMPLE - An optical metrology device is capable of detection of any combination of photoluminescence light, specular reflection of broadband light, and scattered light from a line across the width of a sample. The metrology device includes a first light source that produces a first illumination line on the sample. A scanning system may be used to scan an illumination spot across the sample to form the illumination line. A detector collects the photoluminescence light emitted along the illumination line. Additionally, a broadband illumination source may be used to produce a second illumination line on the sample, where the detector collects the broadband illumination reflected along the second illumination line. A signal collecting optic may collect the photoluminescence light and broadband light and focus it into a line, which is received by an optical conduit. The output end of the optical conduit has a shape that matches the entrance of the detector. | 2016-10-06 |
20160290928 | DEVICE AND METHOD FOR ILLUMINATING A SAMPLE | 2016-10-06 |
20160290929 | Method for Measuring Polymer Concentration in Water Systems - The invention provides a method for measuring the concentration of anionic polymers in an industrial water system. Specifically, the concentration of anionic polymer can be measured by combining an indicator dye composition comprising an acridine compound or a salt thereof to a water sample and measuring the absorbance of the mixture. The concentration can be determined by comparing the absorbance of the mixture to absorbance values on a pre-determined calibration curve. The dosage of anionic polymer can be optionally adjusted based on the concentration. | 2016-10-06 |
20160290930 | APPARATUS AND METHOD FOR ASSESSING OPTICAL QUALITY OF GEMSTONES - Provided herein is an apparatus for assessing a color characteristic of a gemstone. The apparatus comprises an optically opaque platform for supporting a sample gemstone to be assessed, a daylight-approximating light source to provide uniform illumination to the gemstone, an image capturing component, and a telecentric lens positioned to provide an image of the illuminated gemstone to the image capturing component. Also provided are methods of color analysis based on images collected using such an apparatus. | 2016-10-06 |
20160290931 | CONTENT CONDITION DETERMINATION APPARATUS AND CONTENT CONDITION DETERMINATION METHOD - An object of the present invention is to provide a content condition determination apparatus and a content condition determination. Method capable of efficiently determining the conditions of contents in drug-discovery storage tubes a short time using a simple configuration. A content condition determination apparatus includes a tube moving mechanism | 2016-10-06 |
20160290932 | Back-Illuminated Sensor With Boron Layer - An inspection system including an optical system (optics) to direct light from an illumination source to a sample, and to direct light reflected/scattered from the sample to one or more image sensors. At least one image sensor of the system is formed on a semiconductor membrane including an epitaxial layer having opposing surfaces, with circuit elements formed on one surface of the epitaxial layer, and a pure boron layer on the other surface of the epitaxial layer. The image sensor may be fabricated using CCD (charge coupled device) or CMOS (complementary metal oxide semiconductor) technology. The image sensor may be a two-dimensional area sensor, or a one-dimensional array sensor. The image sensor can be included in an electron-bombarded image sensor and/or in an inspection system. | 2016-10-06 |
20160290933 | Optical Inspection System - Provided is an optical inspection system including a supporting unit, allowing a target object to be loaded thereon, a light source unit configured to emit a laser beam toward the target object, a light condensing unit collecting scattered light that is scattered at the target object when the laser beam is irradiated onto the target object, and a control unit controlling the light source unit and the light condensing unit and analyzing the scattered light to examine whether there are pollutants on the target object. The supporting unit may include a first supporting unit, on which the target object is disposed, and which is formed of a first material, and a second supporting unit, which is disposed under the first supporting unit and is formed of a second material different from the first material. | 2016-10-06 |
20160290934 | Optical Die to Database Inspection - Methods and systems for detecting defects on a wafer are provided. One system includes one or more computer subsystems configured for generating a rendered image based on information for a design printed on the wafer. The rendered image is a simulation of an image generated by the optical inspection subsystem for the design printed on the wafer. The computer subsystem(s) are also configured for comparing the rendered image to an optical image of the wafer generated by the optical inspection subsystem. The design is printed on the wafer using a reticle. In addition, the computer subsystem(s) are configured for detecting defects on the wafer based on results of the comparing. | 2016-10-06 |
20160290935 | DEVICE AND METHOD FOR THE DETECTION AND MEASUREMENT OF THE PHYSICAL-CHEMICAL FEATURES OF MATERIALS IN THE FORM OF SHEETS, FILMS, FABRICS, LAYERS DEPOSITED ON A SUPPORT OR THE LIKE - The present invention relates to a device for the detection and measurement of the physical-chemical features of materials in the form of sheets comprising a microwave sensor coupled to a passive reflector on the other side of the material to be measured. The invention further comprises calculation methods and algorithms for processing output data, adapted to make the measurement immune from the typical environmental factors of industrial environments. | 2016-10-06 |
20160290936 | TRANSPARENT TYPE FLAT PANEL X-RAY GENERATION APPARATUS AND X-RAY IMAGING SYSTEM - An X-ray generation apparatus includes: an electron emission device comprising a plurality of electron emission units that emit electrons; a transmission type X-ray emission unit for emitting an X-ray by electrons emitted by the plurality of electron emission units; and a vacuum chamber for shielding the electron emission device and the transmission type X-ray emission unit by using vacuum. An X-ray imaging system includes an X-ray detection apparatus for detecting an X-ray that is irradiated from the X-ray generation apparatus and passes through an object. | 2016-10-06 |
20160290937 | APPARATUS AND METHOD FOR X-RAY GRATING PHASE-CONTRAST IMAGING - A hard X-ray grating phase-contrast imaging apparatus with large field-of-view, high contrast and low dose and the method thereof. The apparatus includes a source emitter ( | 2016-10-06 |
20160290938 | FRONT-LOADING SAMPLE PREPARATION APPARATUS - Disclosed, is a sample preparation apparatus ( | 2016-10-06 |
20160290939 | METHODS AND SYSTEMS FOR IMAGING BULK MOTIONAL VELOCITIES IN PLASMAS - A method and apparatus for imaging the distribution of bulk motional velocities in plasmas such as inertial confinement fusion (ICF) implosions. This method and apparatus use multiple narrow-band x-ray crystal imaging systems, one or more of which have a bandpass tuned to lie within the Doppler-broadened emission line profile of a suitable plasma emission line. Crystals tuned on the one end of the profile will preferentially reflect x-rays from plasma ions moving towards the crystals, while crystals tuned to another end of the profile will preferentially reflect x-rays from plasma ions moving away from the crystals. | 2016-10-06 |
20160290940 | SYSTEM AND METHOD FOR CHEMICALLY AUTHENTICATING ITEMS - A system and method are provided for authenticating an item, comprising selecting a coding site on the item, storing a location of the coding site, selecting a coding material including at least one transition metal, obtaining an original spectrum of the coding material using an X-ray fluorescence spectroscopy device, storing the original spectrum, applying the coding material to the coding site, and authenticating the item. The item is authenticated by accessing the location of the coding site and the original spectrum, obtaining an authentication spectrum of the coding material using an X-ray fluorescence spectroscopy device, and comparing the authentication spectrum to the original spectrum. The item is authentic when the coding material is present at the coding site and the authentication spectrum matches the original spectrum. The item is not authentic when the coding material is not present at the coding site or the spectra do not match. | 2016-10-06 |
20160290941 | NMR Flow Cell - Monitoring cell ( | 2016-10-06 |
20160290942 | Using NMR Response Dependence on Gas Pressure to Evaluate Shale Gas Storage - A disclosed method for characterizing gas adsorption on a rock sample includes: measuring a nuclear magnetic resonance (NMR) response of the rock as a function of surrounding gas pressure along an isotherm; transforming the NMR response to obtain a Langmuir pressure distribution of gas adsorption on the rock sample; and displaying the Langmuir pressure distribution. The Langmuir pressure distribution may be shown in one dimension (e.g., contribution to signal response versus Langmuir pressure), or may be combined with additional pressure-dependencies such as spin-lattice relaxation time (T | 2016-10-06 |
20160290943 | METHOD FOR ANALYZING HONEYCOMB STRUCTURE, AND PROGRAM AND ANALYSIS DEVICE FOR THE SAME - Object information representing a honeycomb structure with a plurality of meshes is obtained, and an inner-wall-surface heat transfer coefficient h | 2016-10-06 |
20160290944 | RESONANT SENSOR AND AN ASSOCIATED SENSING METHOD - A sensing system for selective analyte detection in presence of interferences is presented. The sensing system includes an inductor-capacitor-resistor (LCR) resonant sensor includes a substrate, a plurality of first sensing elements mutually spaced apart and disposed on the substrate, a plurality of second sensing elements, each second sensing element disposed overlapping a corresponding first sensing element of the plurality of second sensing elements, and a protecting film applied onto the plurality of first sensing elements and the plurality of second sensing elements, wherein the protecting film is disposed to be in a physical contact with the analyte and is configured to enable an operational contact of the plurality of first sensing elements and the plurality of second sensing elements with the analyte. | 2016-10-06 |
20160290945 | Method for Measuring Spreading Resistance and Spreading Resistance Microscope - A method includes: removing at least a part of an oxide formed on a surface of the sample by relatively scanning the surface of the sample in X and Y directions parallel to the surface while bringing a probe into contact with the surface of the sample; detecting a signal by bringing the probe into contact with the surface of the sample from which at least a part of the oxide is removed at a predetermined detection position in the X direction or the Y direction while a bias voltage is applied to the sample; calculating a spreading resistance value based on the signal; and retracting the probe to keep the probe relatively away from the surface in a Z direction perpendicular to the surface while relatively moving the probe to a next detection position to start scanning the sample from the next detection position. | 2016-10-06 |
20160290946 | INTEGRATED GAS SENSOR AND RELATED MANUFACTURING PROCESS - An integrated gas sensor having a tungsten/tungsten oxide gas sensing element, is provided with: a substrate of semiconductor material; and a structure of interconnection layers, arranged above the substrate and made of a number of stacked conductive layers and dielectric layers. The gas sensing element is integrated within the structure of interconnection layers and at least one electrode is provided within the structure of interconnection layers, electrically connected to the gas sensing element, designed to provide an electric current to the gas sensing element in order to cause heating thereof. | 2016-10-06 |
20160290947 | GAS SENSOR - A gas sensor is provided with a detection element, a circuit board, and a housing that houses the detection element and the circuit board. The housing has a first fastening section, a second fastening section, and a gas introducing port. The center of the gas introducing port is positioned on a virtual line connecting the first fastening section and the second fastening section, and is disposed corresponding to a corner section of the circuit board, said corner section being close to the first fastening section side. | 2016-10-06 |
20160290948 | ELECTROCHEMICAL SYSTEM COMPRISING A COMPARISON ELECTRODE AND CORRESPONDING MANUFACTURE METHOD - An electrochemical system includes an electrolyte that includes at least one ionic form of a chemical element A chosen from lithium and sodium. The electrolyte is in contact with a comparison electrode, a working electrode and a counterelectrode. The comparison electrode includes a first part in contact with the electrolyte and including a metal M capable of alloying with the chemical element, or a metal alloy of the metal M and of the chemical element A. The comparison electrode also includes a second part including an electrically conducting material, chemically inert with respect to the chemical element A and its ionic form and in direct contact with the first part of the comparison electrode. | 2016-10-06 |
20160290949 | Sampling Plate with Variable Height Testing Zones - A sampling plate ( | 2016-10-06 |
20160290950 | REPLACEABLE MULTISTRIP CARTRIDGE AND BIOSENSER METER - A blood glucose monitor includes a can, a replaceable sensor cartridge that includes a frame, an upper spring disposed between the frame and the can, a case for housing the can and sealing the frame, a lower spring disposed between the can and the case, and a meter housing for sealing an upper portion of the frame. The can is capable of accepting the replaceable sensor cartridge. The frame of the removable cartridge has at least at least two walls defining a chamber for accepting a plurality of biosensors, and a bottom portion defining an opening and at least one sealing flange. The frame can further include a desiccant material capable of reducing humidity within the frame. The frame may be dimensioned such that an interference fit constrains the plurality of biosensors prior to inserting the frame within a blood glucose monitor. | 2016-10-06 |
20160290951 | ANALYTE METER WITH CONTOURED STRIP PORT TO IMPROVE ELECTROCHEMICAL TEST STRIP RELIABILITY - An analyte meter, such as a blood glucose meter, uses electrochemical test strips and has a contoured strip port to improve electrochemical test strip reliability. The analyte meter has a strip connector with strip terminals that electrically connected to strip electrodes when a test strip is inserted through the strip port opening next to the strip connector. The contoured strip port is located next to the strip connector and comprises a strip shelf having side guides for aligning the test strip with the strip port, a strip port opening having a bottom opening extending from a first bottom edge to a second bottom edge, top guides located at a first top edge and a second top edge, and a contoured top extending between the top guides creating an arched clearance above the bottom opening to provide clearance for test strip electrical traces. | 2016-10-06 |
20160290952 | METHOD FOR MANUFACTURING A BIOLOGICAL FLUID SENSOR - The present invention presents a method of fabrication for a physiological sensor with electronic, electrochemical and chemical components. The fabrication method comprises steps for manufacturing an apparatus comprising at least one electrochemical sensor, a microcontroller, and a transceiver. The physiological sensor is operable to analyze biological fluids such as sweat. | 2016-10-06 |
20160290953 | OXYGEN SENSOR ELEMENT - An oxygen sensor element includes a solid electrolyte body having oxygen ion conductivity, a measuring electrode having catalytic action disposed on one surface of the solid electrolyte body, a reference electrode having a catalytic action disposed on another surface of the solid electrolyte body, and a heater for heating the measuring electrode. When the measuring electrode is heated by the heater, when measuring an oxygen concentration in a measured gas, a ratio (%) of an area of a low-temperature region where a surface temperature is less than 450 degrees C. relative to an area of a contact portion exposed to the measured gas G is 15% or less. | 2016-10-06 |
20160290954 | Sensor Device - A sensor device includes: a housing body delimiting within the housing body: a flow duct, and a bypass that branches off from the flow duct at a branching point, the bypass having a wall with an opening; and a sensor element configured to detect a gas content, the sensor element being arranged in the opening. The sensor element has: a sensor body having a longitudinal axis, an electrode chamber within the sensor body, a heating element embedded in the sensor body and by which a predefined region around the electrode chamber is heatable to a predefined operating temperature, an inlet duct coupled to the electrode chamber and having an inlet on the surface of the sensor body, and a thermal insulation sleeve on the sensor body, the thermal insulation sleeve extending at least axially in the direction of the longitudinal axis over a region of the electrode chamber. | 2016-10-06 |
20160290955 | GRAPHENE NANOELECTRONIC HETERODYNE SENSOR FOR RAPID AND SENSITIVE VAPOR DETECTION - An improved sensing method is provided for rapid analyte detection. The method includes: applying an AC excitation signal to the channel region of the transistor; applying an AC drive signal to the transistor; delivering an analyte of interest to a channel region of a transistor; and monitoring a mixing current of the excitation signal and the drive signal through the transistor, where a change in the mixing current is indicative of the concentration of the analyte of interest. | 2016-10-06 |
20160290956 | GAS SENSOR AND METHOD OF MANUFACTURING THE SAME - A gas sensor includes: a channel layer in which a F-terminated GNR, a H-terminated GNR, and a F-terminated GNR whose edge portions are terminated with different modifying groups are bonded to each other; a source electrode formed on one end of the channel layer; and a drain electrode formed on the other end of the channel layer, in which a surface of the H-terminated GNR is exposed, and this exposed portion is a gas sensing part. | 2016-10-06 |
20160290957 | NANOELECTRONIC SENSOR PIXEL - An electrical circuit element, defined as “pixel”, can include at least one silicon nanowire open for contact with a medium for sensing; a metal electrode open for contact with said medium and used for feeding a high-frequency sinusoidal stimulation in impedance measurements and for sensing properties of said medium; implanted source and drain electrodes connected to said silicon nanowire and leaving the gate area and parts of said electrode open for contact with said medium; electrical metal contacts for connecting said pixel to an electrical circuit; and a reference electrode open for contact with said medium for creating a three-electrode-cell system and providing a constant gate potential in the circuit. Some embodiments provide a microelectronic sensor and wearable-patch sensor based on the array of these pixels. Also, some embodiments provide methods for performing DC readout, AC readout and a triple readout combining both DC and AC readouts and temperature sensing. | 2016-10-06 |
20160290958 | OPTOELECTRONIC PIXEL SENSOR - In some embodiments, an electrical circuit element, defined as “optoelectronic pixel”, comprises at least one silicon nanowire decorated with optoelectronically active particles and open for contact with a medium for sensing; a metal electrode open for contact with said medium and used for feeding a high-frequency sinusoidal stimulation in impedance measurements and for sensing properties of said medium; implanted source and drain electrodes connected to said silicon nanowire and leaving the gate area and parts of said electrode open for contact with said medium; electrical metal contacts for connecting said pixel to an electrical circuit; and a reference electrode open for contact with said medium for creating a three-electrode-cell system and providing a constant gate potential in the circuit. In addition, some embodiments provide an optoelectronic sensor and wearable-patch sensor based on the array of the optoelectronic pixels, and the readout methods for these sensors. | 2016-10-06 |
20160290959 | METHOD FOR THE IN-SITU RECALIBRATION OF A COMPARISON ELECTRODE INCORPORATED INTO AN ELECTROCHEMICAL SYSTEM - A method recalibrates in situ a comparison electrode integrated into an electrochemical system. The electrochemical system includes a working electrode, a counter electrode, and an electrolyte. The method includes verifying a potential of the comparison electrode relative to the working electrode or to the counter electrode in situ, detecting whether there is a drift in the potential of the comparison electrode relative to a potential plateau for which the comparison electrode was functionalized or designed, and when the drift is detected, recalibrating the comparison electrode in situ. | 2016-10-06 |
20160290960 | Measurement and Uses of Oxidative Status - The present invention provides a method of determining the overall oxidative status of a body fluid or a tissue of a patient by measuring the oxidation-reduction potential (ORP) of the body fluid or tissue. The method has been found to be useful in the diagnosis, evaluation and monitoring of patients who have suffered a trauma (such as a head injury), patients suspected of being critically-ill or who are critically ill, patients who have an infection, and patients suspected of having a myocardial infarction (MI) or who have had an MI. The method has also been found useful in monitoring and evaluating exercise performance in patients. In addition, the method has been found useful in monitoring and evaluating stored blood products and patients who will receive such a product. | 2016-10-06 |
20160290961 | ABNORMALITY DIAGNOSIS SYSTEM OF A GAS SENSOR - In a limited-current type gas sensor which detects oxygen-containing gas contained in an exhaust gas of an internal combustion engine, the decomposition current value of water (H | 2016-10-06 |
20160290962 | METHOD AND APPARATUS FOR ELECTROPHORESIS - An electrophoresis apparatus includes a membrane heater and controller. The membrane heater is supplied with power from a power supply and has a self-temperature control function. At the time of electrophoresis using a capillary extending inside of a microchip in a first direction, the controller controls supply of power from the power supply to the membrane heater arranged so as to supply heat to a capillary to keep the capillary at an even temperature. | 2016-10-06 |
20160290963 | APPARATUS AND ARRANGEMENT FOR MONITORING A CONDITION OF AN ELONGATED FERROUS OBJECT HAVING A LONGITUDINAL AXIS - There is provided an apparatus for monitoring a condition of an elongated ferrous object having a longitudinal axis, said apparatus including at least one magnetizing circuit including magnetic poles separated along the longitudinal axis, and magnetic field sensors arranged at the poles, said poles including pole shoes for directing magnetic flux between the poles and the monitored object. The pole shoes include openings between the monitored object and the poles, an opening including two ends separated in a direction perpendicular to the longitudinal axis by a mid-section defining a smaller opening than the ends for concentrating the magnetic flux at the mid-section. There is further provided an arrangement including one or more elongated objects for hoisting payload, wherein the monitoring apparatus is attached to the elongated objects. | 2016-10-06 |
20160290964 | PIPELINE TRANSMITTER AND METHOD FOR FABRICATION - The transmitter of this application provides a tubular body fabricated from an aluminum tube into which is inserted an electrical coil formed from high permeability nickel alloy material which is rolled into coiled sheets then inserted one into the second and sometimes third sheet. A battery is inserted into the nickel alloy tubing formed from these coiled sheets and connected to the electrical coil. Electronics comprising a constant output voltage switching power regulator, a Hall effect sensor, a micro-processor and a MOSFET bridge energize the coil in alternating directions providing a magnetic field capable of detection by the transmitter signal detectors used in the pipeline business. The duty cycle and frequency can also be adjusted through an exterior magnetic force pulse generator to communicate with the microprocessor within the transmitter. | 2016-10-06 |
20160290965 | LONG-RANGE MAGNETOSTRICTIVE ULTRASONIC GUIDED WAVE SCANNER SYSTEM AND METHOD - A system for non-destructive inspection of a structure includes a magnetostrictive pulser coil and a ferromagnetic strip. The ferromagnetic strip is coupled to the structure adjacent to the pulser coil. A scanner receiver probe is located adjacent to the ferromagnetic strip. The probe includes a probe body, a position encoder, and a magnetostrictive partial loading receiver coil. A magnet applies a biasing magnetic field to the ferromagnetic strip. A pulser system generates a time-varying current in the pulser coil to induce a time-varying magnetization in the ferromagnetic strip to generate guided wave energy in the structure. The probe detects reflected guided wave energy as the probe is moved around the circumference of the structure. A processor controls the pulser system, records guided wave reflections, and process the guided wave and probe position data to generate a one-dimensional image or a two-dimensional image of anomalies in said structure. | 2016-10-06 |
20160290966 | SYSTEM FOR IN-LINE INSPECTION USING A DYNAMIC PULSED EDDY CURRENT PROBE AND METHOD THEREOF - The present invention provides methods and systems for in-line inspection of a pipe using a dynamic pulsed eddy current probe system that includes of a remote computer, a dynamic pulsed eddy current probe, a data acquisition system, and a delivery apparatus used for nondestructive examination of pipelines. | 2016-10-06 |
20160290967 | SENSOR APPARATUS - A sensor includes an inflow section into which an analyte liquid flows; a first cover member; a detection element including an element substrate located on an upper surface of the first cover member, and a detection section which is located on an upper surface of the element substrate and is configured to detect a target contained in an analyte liquid; an intermediate cover member including a first upstream portion; a second cover member including a second upstream portion; and a flow channel which is surrounded by the intermediate cover member and the second cover member, is continuous with the inflow section, and extends at least to the detection section. A contact angle θ | 2016-10-06 |
20160290968 | Scanning Acoustic Microscope with an Inverted Transducer and Bubbler Functionality - A scanning acoustic microscope includes a transducer mounted below a particular elevation and configured to produce ultrasonic energy, a coupling fluid source configured to introduce coupling fluid between the transducer and the particular elevation. Ultrasonic energy is directed upwardly through coupling fluid disposed between and the transducer and a first surface of a part to be inspected, wherein the part is disposed at the particular elevation and wherein a second surface of the part is not contacted by coupling fluid during inspection. | 2016-10-06 |
20160290969 | MICROFABRICATED ULTRASONIC TRANSDUCERS AND RELATED APPARATUS AND METHODS - Micromachined ultrasonic transducers integrated with complementary metal oxide semiconductor (CMOS) substrates are described, as well as methods of fabricating such devices. Fabrication may involve two separate wafer bonding steps. Wafer bonding may be used to fabricate sealed cavities in a substrate. Wafer bonding may also be used to bond the substrate to another substrate, such as a CMOS wafer. At least the second wafer bonding may be performed at a low temperature. | 2016-10-06 |
20160290970 | MICROFABRICATED ULTRASONIC TRANSDUCERS AND RELATED APPARATUS AND METHODS - Micromachined ultrasonic transducers integrated with complementary metal oxide semiconductor (CMOS) substrates are described, as well as methods of fabricating such devices. Fabrication may involve two separate wafer bonding steps. Wafer bonding may be used to fabricate sealed cavities in a substrate. Wafer bonding may also be used to bond the substrate to another substrate, such as a CMOS wafer. At least the second wafer bonding may be performed at a low temperature. | 2016-10-06 |
20160290971 | Interleaved Acousto-Optical Device Scanning For Suppression Of Optical Crosstalk - A method of scanning a sample includes simultaneously forming a plurality of co-linear scans. Each scan is formed by a sweep of a spot by an acousto-optical device (AOD). The co-linear scans are separated by a predetermined spacing. A first plurality of swaths are formed by repeating the simultaneous forming of the plurality of co-linear scans in a direction perpendicular to the co-linear scans. The first plurality of swaths have an inter-swath spacing that is the same as the predetermined spacing. The predetermined spacing can be a scan length or an integral number of scan lengths. A second plurality of swaths can be formed adjacent to the first plurality of swaths. Forming the second plurality of swaths can be performed in an opposite direction to that of the first plurality of swaths or in a same direction. An inspection system can implement this method by including a diffractive optical element (DOE) path after a magnification changer. | 2016-10-06 |
20160290972 | METHOD OF CONDUCTING PROBE COUPLING CALIBRATION IN A GUIDED-WAVE INSPECTION INSTRUMENT - The method for calibrating an inspection instrument coupled with acoustic transducers disposed at circumferential positions distributed around a surface of an elongated object to inspect generally has the steps of: for each one of the circumferential positions, measuring a first and a second received signal using two acoustic transducers disposed at two axial positions along the object, the received signals resulting from the propagation of an acoustic guided wave signal along the object; identifying an acoustic mode according to the first received and the second received signals using a known period of time associated with the propagation of the acoustic guided wave signal between the two axial positions along the object; and determining a coupling coefficient associated with the acoustic mode, the coupling coefficient being indicative of the coupling of the acoustic transducers on the object; and calibrating the inspection instrument coupled to the object based on the coupling coefficients. | 2016-10-06 |
20160290973 | PHASED-ARRAY PROBE AND A PHASED-ARRAY SEARCH UNIT - The phased-array probe to be received on a probe receiving area of a wedge generally has a probe housing, a plurality of acoustic transducer elements disposed in the probe housing and distributed along a length of a working surface of the probe housing, and a matching layer covering the plurality of acoustic transducer elements and extending to cover an extended region of the working surface of the probe housing such that the matching layer forms a closed contact with an upper end of an acoustic damping junction of the wedge when the working surface of the probe housing of the phased-array probe is received on the probe receiving area of the wedge, wherein the closed contact prevents acoustic energy from being reflected from the extended region of the working surface of the probe housing. | 2016-10-06 |
20160290974 | DETERMINATION OF PIPE WALL FAILURE BASED ON MINIMUM PIPE WALL THICKNESS - Examples of calculating a minimum pipe wall to determine a pipe wall failure probability are disclosed. In one example implementation according to aspects of the present disclosure, a first acoustical sensor is connected to a pipe a distance from a second acoustical sensor connected to the pipe. A computing system is communicatively coupleable to the first and second acoustical sensors. The computing system calculates an average maximum pit depth value of a plurality of pits in an outer surface of a pipe wall of the pipe from a known initial pipe wall thickness value and an average present pipe wall thickness value. The computing system also calculates a minimum present pipe wall thickness by applying a statistical technique to the calculated average maximum pit depth value. The computing system determines a pipe wall failure probability based at least in part on the minimum present pipe wall thickness value. | 2016-10-06 |
20160290975 | METHOD FOR AUTOMATIC IN VITRO DIAGNOSIS - Disclosed is an automatic in-vitro diagnosis method for increasing diagnostic reliability and a diagnosis speed by automatically mixing a specimen taken from the body of a person with a reagent in volumes needed to diagnose the state of the person using the specimen, absorbing the mixture solution of the reagent and the specimen with an analysis strip for a predetermined time, and making a diagnosis by analysis. | 2016-10-06 |
20160290976 | PREPARATIVE SEPARATION CHROMATOGRAPH - Provided is a preparative separation chromatograph including: a chromatograph | 2016-10-06 |
20160290977 | SYSTEM AND METHOD FOR AIR-POLLUTANT SOURCE-LOCALIZATION USING PARKED MOTOR VEHICLES - A method for localizing the source of air pollution that includes receiving pollution data from a network in communication with at least one air pollution sensor that is connected to at least one motor vehicle in a stationary position. Each stationary motor vehicle of the network is positioned at a different air pollution measurement location. The method may further include determining from the pollution data an origin of an air pollutant using an air pollution model provided by a pollutant source localization device including at least one hardware processor. | 2016-10-06 |
20160290978 | METHOD OF CHEMICAL MARKING OF BATCHES OF CARBON DIOXIDE IN ORDER TO ENSURE TRACEABILITY - A method of marking a batch of carbon dioxide including creating by a traceability computer system at least one reference for a batch of carbon dioxide, in a database of a computer system listing a plurality of batches of carbon dioxide; injecting a chemical tracer into the batch of carbon dioxide, the final concentration of the tracer in the batch being less than 1% by mass; and recording the chemical tracer formula in the traceability computer system. The formula of the chemical tracer for the batch is associated with a batch reference in the database, the chemical tracer formula having the form of a combination of proportions of at least two chemical substances. | 2016-10-06 |
20160290979 | SYSTEM AND METHOD FOR AIR-POLLUTANT SOURCE-LOCALIZATION USING PARKED MOTOR VEHICLES - A method for localizing the source of air pollution that includes receiving pollution data from a network in communication with at least one air pollution sensor that is connected to at least one motor vehicle in a stationary position. Each stationary motor vehicle of the network is positioned at a different air pollution measurement location. The method may further include determining from the pollution data an origin of an air pollutant using an air pollution model provided by a pollutant source localization device including at least one hardware processor. | 2016-10-06 |
20160290980 | DETECTION OF AMINES - A sensor can include a conductive region in electrical communication with at least two electrodes, the conductive region can include a complex, and the complex can include a carbon nanotube that is functionalized by a porphyrin. | 2016-10-06 |
20160290981 | Apparatus and Methods for Disintegration Testing - In one embodiment, a disintegration or dissolution testing apparatus ( | 2016-10-06 |
20160290982 | BIOCHEMISTRY BASED OCULAR TOXICITY ASSAY - Disclosed are in vitro methods for predicting the relative irritancy of a test substance. The disclosed methods include a first assay for water insoluble test substances and a second assay for water soluble test substances. The combined results of both assays provide greater sensitivity and accuracy in predicting relative irritancy than tests for water soluble irritants alone. | 2016-10-06 |
20160290983 | SYSTEMS, METHODS, AND A KIT FOR DETERMINING THE PRESENCE OF FLUIDS ASSOCIATED WITH A HYDROCARBON RESERVOIR IN HYDRAULIC FRACTURING - Systems and methods and a kit are provided for using a DNA tracer for the detection of hydraulic fracturing fluid, and further including a method of creating well-specific tracers. | 2016-10-06 |
20160290984 | SYSTEMS AND METHODS FOR SCREENING SOLVENTS FOR DISSOLVING TANK BOTTOM SLUDGE - A method of screening solvents for the solubilization of petroleum hydrocarbons is disclosed. The method includes dissolving petroleum hydrocarbons in a selected solvent to form a first solution, adding an ionic liquid to the first solution and blending to form a second solution and measuring absorbance of the second solution using spectroscopic techniques. The solubilization of petroleum hydrocarbons in the solvent is then determined based on the difference between the measured absorbance of the first and second solution. A system for screening solvents for the solubilization of petroleum hydrocarbons is also disclosed. The system can be used in removal of wax deposition in refinery process equipment, process flow lines, during piping operations, upgradation of wax, prevention of clogging of pipelines, processing of sludge or for removing sludge from petroleum tank installations and enhancing the crude oil flow. | 2016-10-06 |
20160290985 | METHOD AND APPARATUS FOR CONTINUOUS MONITORING OF QUALITY AND MOISTURE PARAMETERS OF LIQUIDS - This application relates to a method and a system for determining aging of a liquid. The method includes steps for measuring a relative water content (rS | 2016-10-06 |
20160290986 | METHODS OF IDENTIFYING CROSSLINKING MOLECULES FOR POLYMERS - Methods for screening molecules or moieties for their ability to crosslink are disclosed. An aromatic carbonate, aromatic ester, or aliphatic ester group is attached to the molecule to mimic the presence of a polymer. A solution of the modified molecule is irradiated, and the first-order kinetic rate constant is measured. If the rate constant is high enough or a threshold amount of the molecule is consumed, a polymer is synthesized using the molecule/moiety as an endcap or co-monomer. The polymer is irradiated, and the increase in crosslink density and the gel formation percentage are determined. These parameters, if high enough, indicate the suitability of the molecule/moiety to act as a crosslinking agent, particularly for polycarbonates. Alternatively, the molecule/moiety may be identified as suitable solely by its first-order kinetic rate constant. | 2016-10-06 |
20160290987 | Biosensor Comprising Electrode for Measuring Hematocrit Value - Provided is a method for measuring the concentration of a substance in a blood sample, comprising: supplying the blood sample to a biosensor comprising a hematocrit electrode for measuring a hematocrit value on the surface of which electrode an electrically conductive polymer is covalently immobilized; and calculating the concentration of the substance from the measured value of a first current resulting from application of a first voltage; and correcting the concentration of the substance with the value of a second current resulting from application of a second voltage or the hematocrit value calculated from the value of the second current. | 2016-10-06 |
20160290988 | Current Measuring Device, Current Measuring Method, and Current Measuring Kit - Conventionally, only a pair of electrodes is provided and nanopores arranged in parallel are connected by an electrolyte solution, and therefore a change in an ion current to be measured is a sum of changes in ion currents generated in the respective nanopores. The invention includes: a first solution chamber including a plurality of first electrodes; a second solution chamber including a second electrode which is a counter electrode of the first electrodes; a membrane provided between the first solution chamber and the second solution chamber, the membrane having a plurality of small holes; a measuring unit for applying a voltage between the first electrodes and the second electrode and measuring a current flowing between the first electrodes and the second electrode via the small holes; and an insulating structure forming unit for forming, in the first solution chamber, an insulating structure for insulating the first electrodes in a state in which a conductive liquid is filled between the small holes and the first electrodes and achieves parallel measurement of ion currents by using nanopores. | 2016-10-06 |
20160290989 | MARKER DETECTION FOR CHARACTERIZING THE RISK OF CARDIOVASCULAR DISEASE OR COMPLICATIONS THEREOF - The present invention provides methods, systems, devices, and software for determining values for one or more markers in order to characterize a subject's risk of developing cardiovascular disease or experiencing a complication thereof (e.g., within the ensuing one to three years). In certain embodiments, the markers are those derived from a blood sample using a hematology analyzer operably linked to a software application that is configured to compute a risk score for a subject based on the values for the markers detected in the blood sample. | 2016-10-06 |
20160290990 | URINE SAMPLE ANALYZER, URINE SAMPLE DISPENSING METHOD AND URINE SAMPLE ANALYZING METHOD - Disclosed is a urine sample dispensing method. The method comprises: (i) suctioning a urine sample using a nozzle; (ii) flowing the urine sample suctioned by the nozzle through a filter for capturing foreign matter, the filter being provided in a flow path connected to the nozzle; and (iii) changing a flow course of the urine sample or a position of the filter so that the filter is not positioned on the flow course of the urine sample, when the urine sample that has passed through the filter is discharged from the nozzle. | 2016-10-06 |
20160290991 | URINE SAMPLE ANALYZER AND URINE SAMPLE DISPENSING METHOD - Disclosed is a sample dispensing method. The method comprises: suctioning a urine sample from a sample container by a first nozzle; moving the first nozzle to a holding chamber after the first nozzle has suctioned the urine sample from the sample container, and discharging the urine sample into the holding chamber; moving the first nozzle to a first wash tank and washing the first nozzle in the first wash tank after the first nozzle has discharged the urine sample into the holding chamber; and moving a second nozzle to the holding chamber after the first nozzle has started moving to the first wash tank, and moving the second nozzle which has suctioned the urine sample from the holding chamber to respective plurality of processing chambers and discharging a part of the urine sample to the respective plurality of processing chambers. | 2016-10-06 |
20160290992 | METHOD FOR ANALYZING DROPLETS - A method for analyzing droplets is described. The droplets can be received on an outer surface region of a sampler surface disposed on a substrate, wherein the sampler surface is increasingly less hydrophobic along a radial direction toward the center of the sampler surface. Next, the droplets can be aggregated and moved toward the center of the sampler surface. The droplets can then be received at an inner surface region of the sampler surface. Next, the droplets can be analyzed using an analysis mechanism in an area in the inner surface region. | 2016-10-06 |
20160290993 | Biological Particle Analyzer and Method of Analyzing Biological Particles - A method of analyzing biological particles for a biological particle analyzer includes outputting a first detection result when at least one particle has arrived at the first detection area, outputting a second detection result to the control module when the particles have arrived at the second detection area, and determining when to turn on or off the light emission source and outputting a control signal to turn on or off the light emission source according to the first detection result, wherein a control module is configured to calculate a turn-on time according to different particle characteristics and an average velocity of the at least one particle, and the light emission source is turned on only when the at least one particle is being tested during the turn-on time. | 2016-10-06 |
20160290994 | SUBSTRATES AND METHODS FOR STAINING LIVE STEM CELLS - The invention relates to novel substrates and methods for staining live stem cells. The stain may be used to identify induced pluripotent stem cell colonies during the process of somatic cell reprogramming. | 2016-10-06 |
20160290995 | METHODS OF SELECTING AKT AGONISTS OR ANTAGONISTS - Disclosed herein are methods of identifying a test compound as agonists or antagonists of Akt activity. The methods involve contacting the test compound with a cell that expresses a biosensor comprising a FOXO1 or HDHB polypeptide and a fluorescent protein and locating the biosensor within the cell. Locating the biosensor in the nucleus relative to the cytoplasm is an indication that the test compound has an effect upon Akt activity. | 2016-10-06 |
20160290996 | METHOD FOR ISOLATING APOPTOTIC BODIES - The invention pertains to the field of the study of apoptosis, especially the field of the prognosis and monitoring of diseases wherein apoptosis occurs. Concretely, the invention relates to a method for isolating apoptotic bodies from a sample of body fluid, and to methods for the prognosis and evaluation of the efficiency of a treatment for vascular, neurodegenerative and/or oncological diseases, based on the use of said method for isolating apoptotic bodies. | 2016-10-06 |
20160290997 | Polyporus Squamosus-Derived Recombinant Lectin Specific for Sialic Acid Linkage - The present invention relates to a method for producing a | 2016-10-06 |
20160290998 | REAGENT SYSTEM AND METHOD FOR MODIFYING THE LUMINESCENCE OF LANTHANIDE (III) MACROCYCLIC COMPLEXES - A spectrofluorimetrically detectable luminescent composition consists essentially of at least one energy transfer acceptor lanthanide(III) complex having an emission spectrum maximum in the range from 300 to 2000 nanometers and a luminescence-enhancing amount of at least one energy transfer donor selected from the group consisting of a fluorophore, a lumiphore, an organic compound, a salt of an organic ion, a metal ion, a metal ion complex, or a combination thereof. Such energy transfer donor enhances the luminescence of at least one energy transfer acceptor lanthanide(III) complex, with the conditions that the emission spectrum of any energy transfer donor differs from that of its energy transfer acceptor lanthanide(III) complex; and such energy transfer donor can be dissolved to form a unitary solution in a solvent having an evaporation rate at least as great as that of water. | 2016-10-06 |
20160290999 | METHOD OF DETERMINING TEMPERATURE AND METHOD OF DETECTING A TARGET PEPTIDE - Disclosed is a method of determining whether a temperature of a sample has reached a predetermined temperature. The method comprises the steps of: mixing an albumin-containing sample with a peptide reagent comprising a peptide for temperature determination; heating the mixture; detecting an optical change of the mixture; and determining whether the temperature of the mixture has reached the predetermined temperature based on the detection result of the optical change. In the method, a dissociation constant (K | 2016-10-06 |
20160291000 | METHODS OF STABILIZING MOLECULES WITHOUT REFRIGERATION USING WATER SOLUBLE POLYMERS AND APPLICATIONS THEREOF IN PERFORMING CHEMICAL REACTIONS - The present application is directed to methods of performing chemical reactions, including multi-step chemical reactions in which two or more of the reagents in the chemical reaction are incorporated or entrapped in a solid polymeric structure comprising pullulan. In certain embodiments, the chemical reaction or multi-step reaction serves as a sensor. Accordingly the present application is also directed to sensors for performing the methods of the application. In certain embodiments, at least one of the reagents is a biomolecule and the sensor is a biosensor. In certain other embodiments, the solid polymeric structure comprising pullulan and the reagents for performing a chemical reaction form a convenient device for performing a chemical reaction. | 2016-10-06 |
20160291001 | CONDUCTIVE HYDROGELS FOR AFFINITY SENSING - The present invention provides a sensor for detection of disease markers, and methods for detecting a disease marker, using a conductive hydrogel modified with a biorecognition element. | 2016-10-06 |
20160291002 | Sample Preparation and Specific Capture for Multiplex Detection of Target Analytes (i.e., Bacteria, Viruses, Etc.) - A method and apparatus for the rapid and reliable preparation of a sample for use in testing for target analytes such as bacteria, viruses, toxins and pathogenic agents in various products. A sample for testing the target analyte is collected from various sources. The method for sample preparation provides for an express process for preparing collected samples for testing. The collected sample may be concentrated by centrifugation, filtration, or other means suitable for sample concentration, homogenized with the addition of a broth and enriched for specified period of time. Immunomagnetic separation of the sample occurs with receptor-coated magnetic microspheres in different test-specific formulations (singleplex or multiplex). An automatic testing system is disclosed which includes a biological testing cassette, in which testing of the sample occurs using liquid crystal diagnostic methodologies. | 2016-10-06 |
20160291003 | METHOD OF DETECTING TARGET SUBSTANCE - A method of detecting a target substance, containing the steps of:
| 2016-10-06 |
20160291004 | CARTRIDGE FOR ASSAYS WITH MAGNETIC PARTICLES - A cartridge for detection of target components in a liquid sample includes a sample chamber, at least two reservoirs that can be furnished with magnetic particles, and at least two corresponding sensitive zones in which solved magnetic particles and/or target components can be detected. When a magnetic actuation field of a given configuration is established in the sample chamber, the magnetic particles of different reservoirs migrate predominantly to different sensitive zones. Thus a mixing of magnetic particles can be avoided. | 2016-10-06 |
20160291005 | SENSORS HAVING INTERNAL CALIBRATION OR POSITIVE CONTROLS - Analyte-detecting sensor devices include a test sensor, a reference sensor and one or more positive control or calibration sensors. The sensors are in fluid communication with each other. For example, the sensors may be positioned in and in fluid communication with a flow path of the sensor device. | 2016-10-06 |
20160291006 | MICROARRAY SYSTEM AND A PROCESS FOR DETECTING TARGET ANALYTES USING THE SYSTEM - A process for identifying one or more target analytes present in a sample includes contacting a microarray with the sample. The microarray has at least two microbead subpopulations with randomly distributed spatial positions, each of the subpopulations comprising microbeads having a known active agent capable of binding with a respective target analyte. After contacting the microarray with the sample, the spatial positions of the microbeads which have undergone a change that is indicative of a respective one of the active agents being bound to a corresponding one of the target analytes are determined. At least one of the microbead subpopulations which has undergone the change is identified by comparing the determined spatial positions to recorded spatial positions of the microbeads of the microbead subpopulations stored in an encoding/decoding data table. The target analytes are identified based on the known active agents belonging to the at least one identified microbead subpopulation. | 2016-10-06 |
20160291007 | POLYNUCLEOTIDE CONJUGATES AND METHODS FOR ANALYTE DETECTION - The present disclosure provides polynucleotide conjugates, methods, and assay systems for use in detecting the presence, absence, and/or amount of an analyte in a sample. Various polynucleotide conjugates, conjugate pairs, sets, libraries, and assay systems comprising the same are disclosed. In particular, methods and assay systems for antibody detection and analysis are provided. For example, assays capable of high levels of multiplexing are used for antibody detection and analysis in a biological sample, e.g., Lyme disease patient samples. The presently disclosed polynucleotide conjugates, methods, and assay systems can be used to provide sensitive and reliable diagnosis, even at early stages of a disease or condition. Use for monitoring disease progression and prognosis is also disclosed. | 2016-10-06 |
20160291008 | METHODS AND ASSAYS FOR FACTOR VIII ACTIVITY - The methods and compositions described herein relate to the measurement of factor VIII (fVIII) levels and/or activity. | 2016-10-06 |
20160291009 | MULTI-WELL CUVETTE PROVIDED WITH INTEGRATED REACTION AND DETECTION MEANS - The present application discloses a multi-well cuvette for integrating the reaction between a sample and a reagent with the detection of a specific analyte included therein, and the multi-well cuvette comprises: a reaction chamber part having a sample and a reagent placed therein; and a detection part for detecting the reaction between the sample and the reagent, wherein the reaction chamber part comprises: an extraction member standby chamber in which a member for dividing or distributing the sample is on standby; a sample filling chamber; and a reagent filling chamber which is filled with the reagent, and in which the reaction with the sample is carried out, wherein the detection part comprises: a chromatography analysis means for a reactive product between the sample and the reagent; and a detection chamber for accommodating the same. | 2016-10-06 |
20160291010 | IMMUNOCHROMATOGRAPHY STRIP SENSOR CAPABLE OF MEASURING BIOMATERIAL CONCENTRATION OVER BROAD CONCENTRATION RANGE - The present invention relates to an immunochromatography strip sensor capable of measuring a biomaterial concentration over a broad concentration range, and a method for measuring a biomaterial concentration over a broad concentration range using the sensor. A detection method using the sensor according to the present invention can accurately measure an antigen concentration over a broad concentration range, and achieve a low cost, rapidity and convenience, and thus the method is suitable for a point of care test (POCT) requiring rapidity and high sensitivity. | 2016-10-06 |
20160291011 | Biomarkers for Cardiodiabetes - The invention provides compositions and methods for determining cardiodiabetes status in a subject. The invention also provides compositions and methods for treating a subject experiencing cardiodiabetes. | 2016-10-06 |
20160291012 | MYCOBACTERIUM BIOMARKERS AND METHODS - This disclosure provides a method for detecting infection of an animal by | 2016-10-06 |
20160291013 | DEVICES AND ASSAYS FOR DIAGNOSIS OF SINUSITIS - Methods and kits for sampling mucous from within a sinus to determine if a single sample includes one or more bacterial types indicating bacterial sinusitis. | 2016-10-06 |
20160291014 | BIOCONJUGATES OF HETEROCYCLIC COMPOUNDS - The invention provides bioconjugates of heterocylic compounds such as S-adenosylmethionine and S-adenosylhomocysteine with biotin or digoxigenin. The bioconjugates also include carbon and nitrogen linker moieties of varying length that are used to attach such compounds to biotin or digoxigenin. The conjugates are useful in immunoassays. The invention provides a method for detecting SAM and SAH, comprising the steps of: (a) preparing the following components: (i) bio-conjugates of SAM, SAM analogs or SAH; (ii) an europium, a terbium cryptate or other fluorophore as a donor that has a specific ligand for the tracer in the bio-conjugates of (i); (iii) an acceptor fluorescent dye that has the excitation spectra overlap those of donor's emissions and has an antibody specific for SAM or SAH labeled; (b) addition of the biological fluid containing said SAM or SAH; and (c) spectroscopic measurement of the fluorescence of the donor and the fluorescence of from the acceptor. | 2016-10-06 |
20160291015 | METHOD FOR DETERMINING THE LEVEL OF AGGLUTINATION OF PARTICLES IN A SAMPLE - The invention relates to a method for quantifying the level of agglutination of particles in a sample, in particular a biological sample, and notably blood. The biological sample is positioned between a light source and a matrix photodetector. The image acquired by the photodetector is representative of the level of agglutination of the particles in the sample. The light source emits a light wave, the spectral band of which extends an optimum 400 and 600 nm, which constitutes an optimum an excessively low absorption and excessively high absorption, given the thickness of the sample. | 2016-10-06 |
20160291016 | NEW MARKERS FOR SEVERE PROGRESSION OF IDIOPATHIC SCOLIOSIS AND USES THEREOF TO STRATIFY SCOLIOTIC PATIENTS AND PREDICT THE RISK OF DEVELOPING SCOLIOSIS - Methods of stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's PTPμ expression and/or activity and/or PIPK1γ expression and/or activity. Also provided are methods of predicting the risk of developing a scoliosis also based on the subject's PTPμ expression and/or activity and/or PIPK1γ expression and/or activity; and methods of increasing GiPCR signaling in cells of a subject in need thereof comprising administering to the subject's cells an effective amount of an inhibitor of PIPK1γ tyrosine phosphorylation; an activator of PIPK1Y tyrosine dephosphorylation; and/or an inhibitor of PIPK1γ expression and/or activity. | 2016-10-06 |
20160291017 | BIOMARKER FOR MELK ACTIVITY AND METHODS OF USING SAME - The methods of the present invention, relate to the surprising determination that the level of phosphorylation of position 406 (e.g., a serine residue) of human eukaryotic initiation factor 4B (eIF4B), or a corresponding phosphorylatable amino acid of an ortholog thereof, serves as a biomarker for MELK enzymatic (e.g., kinase) and/or oncogenic activity. The methods of the present invention further relate to the surprising determination that the level of phosphorylation of position 3 (e.g., a threonine residue) and/or position 10 (e.g., a serine residue) and/or position 11 (e.g., a threonine residue) of human Histone M3, or a corresponding phosphorylatable amino acid of an ortholog thereof, also serves as a biomarker for MELK enzymatic (e.g., kinase) and/or oncogenic activity. | 2016-10-06 |
20160291018 | USE OF PCSK9 AND LDL-R ACTIVITY FOR TREATING CARDIOVASCULAR RISK - The present disclosure provides methods of assessing cardiovascular risk in a subject and/or of treating a subject having or at risk of developing a cardiovascular disease or disorder. In some embodiments, the method comprises determining an activity level of PCSK9 and/or a level of PCSK9 in a sample obtained from the subject, and initiating or modifying a treatment regimen. | 2016-10-06 |
20160291019 | System for Detecting Rare Cells - A system for detecting rare cells in a fluid is disclosed. The system includes a substrate and a mixture disposed on the substrate and including a carrier and a thermo-responsive polymer for capture and release of the rare cells. Also disclosed is a method for detecting rare cells in a fluid using a system including a substrate and a mixture that is disposed on the substrate. The mixture includes a carrier and a thermo-responsive polymer. The method includes providing the system and introducing a sample of fluid containing the rare cells into the system such that the sample interacts with the carrier for capturing the rare cells. | 2016-10-06 |
20160291020 | HCV CORE LIPID BINDING DOMAIN MONOCLONAL ANTIBODIES - The present invention relates to monoclonal antibodies for the detection of HCV antigen. More specifically, the invention describes antibodies against HCV core antigen lipid binding domain and immunoassay methods, kits and compositions for use in detecting HCV infection. | 2016-10-06 |
20160291021 | Method for In Vitro Diagnosing and Prognosing of Triple Negative Breast Cancer Recurrence - The present invention is in the technical field of breast cancer management, and more particularly relates to the diagnosis and/or prognosing of triple-negative breast cancer (TNBC). The invention is more particularly based on the finding that specific biomarkers are abberantly expressed in patients suffering from a triple-negative breast cancer recurrence, and are highly related to the aggressiveness of this disease, and thus to survival of said patient. | 2016-10-06 |