42nd week of 2013 patent applcation highlights part 51 |
Patent application number | Title | Published |
20130274079 | EXERCISE MACHINE WITH UNSTABLE USER SUPPORT - An unstable user support device designed for mounting on an exercise machine has a base or mounting bracket and a user support platform configured for engagement by the user and pivotally mounted on the base for pivotal movement through a limited angle about a pivot axis extending in a plane parallel to the user support platform, The pivoting movement may be a side to side tilting movement. Stops between the base and support platform control the amount of pivoting movement. This arrangement provides a degree of instability to the platform, to provide a greater challenge to the user's core muscles in balancing the platform while performing an exercise motion. | 2013-10-17 |
20130274080 | EXERCISE ASSISTING TOOL - An exercise assisting tool includes a seating surface on which a user is seated, and a body portion having a bottom surface formed in a substantially spherical shape. A height H of the seating surface at a lowermost point is set in a range from 100 mm to 450 mm, and a regulator is further provided to suppress any slippage of buttocks of the user from the seating surface. The exercise assisting tool is structured so that the user seated on the seating surface is allowed to tilt the seating surface in all directions while having the bottom surface in contact with the ground surface. | 2013-10-17 |
20130274081 | MACHINE FOR INSERTING HONEYCOMB SEPARATORS IN BOXES - A machine for inserting honeycomb separators into boxes, comprising: at least two gripping elements ( | 2013-10-17 |
20130274082 | Centrifugal Separator With Circular Rotor Blades - An improved centrifugal separator system and method for separating a solid portion from a liquid portion, of the type including a chute for introducing material into the separator; a screen rotated on a shaft for allowing a liquid portion of the material to flow through the screen but preventing solids from flowing through the screen; a space between the housing and the screen for allowing the solids to travel through the separator; a rotor portion, further comprising a plurality of blades radiating outward from a hub portion of the rotor to an outer ring portion of the rotor to define the traveling space for the solid material between the rotor blades; wherein each of the blades being circular in cross section along their length to minimize the impact on the solid material which makes contact with the rotating blades and do less damage to the solid material, resulting in better product and a reduction in the energy required to power the separator. | 2013-10-17 |
20130274083 | ISOLATION OF SINGLE-WALLED CARBON NANOTUBES FROM DOUBLE AND MULTI-WALLED CARBON NANOTUBES - A method and system are disclosed for separating single-walled carbon nanotubes from double and multi-walled carbon nanotubes by using the difference in the buoyant density of Single-Walled versus Multi-Walled carbon nanotubes. In one embodiment, the method comprises providing a vessel with first and second solutions. The first solution comprises a quantity of carbon nanotubes, including single-walled carbon nanotubes and double and multi-walled carbon nanotubes. The single walled nanotubes have a first density, the double and multi-walled nanotubes having a second density. The second solution in the vessel has a third density between said first and second densities. The vessel is centrifuged to faun first and second layers in the vessel, with the second solution between said first and second layers. The single-walled carbon nanotubes are predominantly in the first layer, and the second and multi-walled carbon nanotubes are predominantly in the second layer. | 2013-10-17 |
20130274084 | CENTRIFUGAL SEPARATOR AND A LIQUID PHASE DISCHARGE PORT MEMBER - A centrifugal separator comprises a bowl rotating in use around an axis of rotation. The axis of rotation extends in a longitudinal direction, and a radial direction extends perpendicular to the longitudinal direction. A base plate provided at one longitudinal end of the bowl, said base plate having an internal and external side, an outlet opening being provided in the base plate. A casing is projecting at the outlet opening on the external side of said base plate, said casing comprising a casing side, a normal to said casing side extending at an acute angle relative to a circumferential direction of the bowl at said casing and a discharge opening is provided in said casing side. The discharge opening is radially outwardly limited by a weir with an overflow edge and said discharge opening extending radially inwardly to a position above a highest intended level of liquid in the bowl. | 2013-10-17 |
20130274085 | WHITE, OPAQUE BETA-SPODUMENE/RUTILE GLASS-CERAMIC ARTICLES AND METHODS FOR MAKING THE SAME - Crystallizable glasses, glass-ceramics, IXable glass-ceramics, and IX glass-ceramics are disclosed. The glass-ceramics exhibit β-spodumene ss as the predominant crystalline phase. These glasses and glass-ceramics, in mole %, include: 62-75 SiO | 2013-10-17 |
20130274086 | ALKALI FREE GLASS AND METHOD FOR PRODUCING ALKALI FREE GLASS - The present invention relates to an alkali-free glass having a strain point of 725° C. or higher, an average thermal expansion coefficient at from 50 to 300° C. of from 30×10 | 2013-10-17 |
20130274087 | METAL ORGANIC FRAMEWORK MODIFIED MATERIALS, METHODS OF MAKING AND METHODS OF USING SAME - MOF (metal organic framework)-modified materials and methods of making and methods of using same. The MOFs are covalently bound to the materials. Examples of suitable materials include fibers and thin films. The MOF-modified materials can be made by forming MOFs in situ such that they are covalently bound to the materials. The MOF-modified materials can be used in methods where gases and/or toxic chemicals are absorbed. | 2013-10-17 |
20130274088 | METHOD FOR PRODUCING WATER-ABSORBENT RESIN - A method for producing a water-absorbent resin by a reversed-phase suspension polymerization method, includes step 1 of dispersing a first aqueous solution containing a partially neutralized product (A) of a water-soluble ethylenically unsaturated monomer having acid groups in the molecule in a petroleum-type hydrocarbon dispersion medium in the presence of a dispersing agent, and then polymerizing the resulting dispersion to obtain a slurry containing primary particles of a polymer, and step 2 of adding a second aqueous solution containing a partially neutralized product (B) of a water-soluble ethylenically unsaturated monomer having acid groups in the molecule to the slurry obtained in step 1, and then polymerizing the mixture to obtain a slurry in which the primary particles are agglomerated. In the method, a molar neutralization degree X of the partially neutralized product (A) is set larger than a molar neutralization degree Y of the partially neutralized product (B), and also a difference between the molar neutralization degree X and the molar neutralization degree Y is set to 5% or more. The dispersing agent usable herein is at least one member among those of a surfactant and a polymer-type dispersing agent. The water-absorbent resin produced by this method suppresses odor originating from a dispersion medium and odor generated with the lapse of time after absorption of a body fluid or the like. | 2013-10-17 |
20130274089 | Method for Producing a Platinum Catalyst Precursor - The present invention relates to a method for producing a precursor of a supported platinum catalyst. To provide a method for producing a platinum catalyst precursor, by means of which supported platinum catalysts can be produced which have a relatively high activity, a method is proposed, comprising the steps of:
| 2013-10-17 |
20130274090 | LIGHT CONVERSION ELEMENT CONTAINING IONIC LIQUID, A PROCESS FOR MAKING SAME, AND AN APPARATUS COMPRISING THE LIGHT CONVERSION ELEMENT - To provide a light conversion element which has solved the problems of the reduced intensity of upconverted light, etc., due to the flammability, volatility or high viscosity of a medium used in the conventional photon upconversion elements. | 2013-10-17 |
20130274091 | PROCESS FOR SYNTHESIS OF DOPED TITANIA NANOPARTICLES HAVING PHOTOCATALYTIC ACTIVITY IN SUNLIGHT - Present disclosure provides a process for the synthesis of doped titania nanoparticle having photocatalytic activity greater than 90% at 2 hours under sunlight irradiation. The process involves step a) milling a mixture containing anatase titania and a precursor compound, the compound selected from the group consisting of metal and non-metal salts, in the presence of water and oxide milling media, at a temperature in the range of 20 to 50° C. for a period of 60-120 minutes, to form a slurry, wherein the amount of water is in the range of 15 to 25% by weight of the total mixture; and
| 2013-10-17 |
20130274092 | CATALYST COMPOSITION - The disclosure provides a catalyst composition, including: a metal or metal compound; and an organic diacid metal salt. The metal includes titanium (Ti), stibium (Sb) or combinations thereof and the metal compound includes antimony oxide (Sb | 2013-10-17 |
20130274093 | IRON AND COBALT BASED FISCHER-TROPSCH PRE-CATALYSTS AND CATALYSTS - A method of making iron and cobalt pre-catalysts and catalysts in activated, finished form suitable for use in Fischer-Tropsch synthesis. The pre-catalysts are prepared by mixing an iron or cobalt salt, a base, and a metal oxide textural promoter or support. The reaction is carried out in a solvent deficient environment. The resulting product is then calcined at temperatures of about 300-500° C. to produce a metal oxide. The catalysts are prepared by reducing the metal oxide in the presence of hydrogen at temperatures of about 300-500° C. and carbiding the reduced metal in the case of iron. | 2013-10-17 |
20130274094 | Catalysts For The Conversion Of Hydroxypropionic Acid Or Its Derivatives To Acrylic Acid Or Its Derivatives - Catalysts for dehydrating hydroxypropionic acid, hydroxypropionic acid derivatives, or mixtures thereof to acrylic acid, acrylic acid derivatives, or mixtures thereof with high yield and selectivity, short residence time, and without significant conversion to undesired side products, such as, for example, acetaldehyde, propionic acid, and acetic acid, are provided. The catalysts are mixed condensed phosphates. Methods of preparing the catalysts are also provided. | 2013-10-17 |
20130274095 | Catalysts For The Production Of Acrylic Acid Or Its Derivatives - Catalysts for dehydrating hydroxypropionic acid, hydroxypropionic acid derivatives, or mixtures thereof to acrylic acid, acrylic acid derivatives, or mixtures thereof with high yield and selectivity, short residence time, and without significant conversion to undesired side products, such as, for example, acetaldehyde, propionic acid, and acetic acid, are provided. The catalysts are mixed protonated monophosphates. Methods of preparing the catalysts are also provided. | 2013-10-17 |
20130274096 | CATALYST SUPPORT MATERIALS WITH OXYGEN STORAGE CAPACITY (OSC) AND METHOD OF MAKING THEREOF - A new type of catalyst support with oxygen storage capacity (OSC) and methods of making the same are disclosed. The composition ratio is x(Ce | 2013-10-17 |
20130274097 | INSTALLATION AND METHOD FOR CONVERSION OF PAPER RESIDUE INTO A MINERAL PRODUCT - A method and apparatus for conversion of paper residue into a mineral product uses a fluidized bed device with a distribution plate for securing an even distribution and supply of at least combustion air to the bed material and to the paper residue. An air box below the distribution plate supplies combustion air to the bed material and paper residue above the distribution plate. A heat exchanging section receives in separate parts ambient air and flue gases from the fluidized bed device for exchanging heat between flue gases and ambient air. The heat exchanging section is connected to the air box for supplying the heated ambient air to the air box for use as combustion air. A control system is employed for controlling the amount of bed material and the dimension of its particles and is arranged to monitor and maintain a process parameter within a predefined range. | 2013-10-17 |
20130274098 | MAGNESIUM HALIDE SUPPORT FOR USE AS A COMPOSITION OF A CATALYST FOR THE OLEFIN POLYMERIZATION, AND METHOD OF PREPARATION OF THE MAGNESIUM HALIDE SUPPORT - An aspect of the present invention is a preparation of a magnesium halide support for using as a composition of a catalyst in an olefin polymerization, wherein the magnesium halide support is a solid substance prepared by an aliphatic alcohol non-ionic surfactant, preferably is ethoxylated aliphatic alcohol. Another aspect of the present invention is a method for the preparation of the magnesium halide support for using as the composition of the catalyst in the olefin polymerization comprising the following steps: (a) adding a magnesium halide compound into an organic solvent, and heating; (b) cooling down the mixture from (a) rapidly to the room temperature or lower in the inert organic solvent and the aliphatic alcohol non-ionic surfactant; and (c) washing the magnesium halide with the anhydrous inert organic solvent, and drying, wherein the aliphatic alcohol non-ionic surfactant is ethoxylated aliphatic alcohol. | 2013-10-17 |
20130274099 | Synergistic Fungicidal Active Substance Combinations - The novel active compound combinations of a carboxamide of the general formula (I) (group 1) | 2013-10-17 |
20130274100 | Synergistic Fungicidal Active Substance Combinations - The novel active compound combinations of a carboxamide of the general formula (I) (group 1) | 2013-10-17 |
20130274101 | Synergistic Fungicidal Active Substance Combinations - The novel active compound combinations of a carboxamide of the general formula (I) (group 1) | 2013-10-17 |
20130274102 | BIOLOGICAL-BASED CATALYST TO DELAY PLANT DEVELOPMENT PROCESSES - The present invention is directed to methods for delaying a plant development process comprising exposing a plant or plant part to one or more bacteria or enzymes. In specific embodiments, the one or more bacteria are selected from the group consisting of | 2013-10-17 |
20130274103 | METHOD FOR PREPARATION OF AN AQUEOUS GLYPHOSATE CONCENTRATE - A method for preparing an aqueous mixture of glyphosate salts to improve the handling of the mixture, the method comprising forming a homogeneous mixture of at least two bases comprising at least one alkali metal hydroxide, and at least one further base selected from alkali metal hydroxides and nitrogen bases and reacting the mixture of the at least two bases with glyphosate acid in an aqueous reaction medium to provide an aqueous mixture of glyphosate salts wherein the concentration of glyphosate (based on glyphosate acid equivalent) is at least 200 gae/L. | 2013-10-17 |
20130274104 | AGROCHEMICAL MIXTURES FOR INCREASING THE HEALTH OF A PLANT - The present invention relates to an agrochemical mixture for increasing the health of a plant, comprising as active compounds 1) pyraclostrobin (compound A) and 2) harpin protein (compound B) selected from harpin | 2013-10-17 |
20130274105 | HERBICIDAL COMPOSITION AND METHOD OF USE THEREOF - The present invention relates to a herbicidal composition comprising topramezone and a pyridine herbicide. The invention also relates to methods of controlling the growth of weeds, and to the use of this composition. | 2013-10-17 |
20130274106 | HERBICIDAL COMPOSITION - To provide a technology for controlling weeds and the like. A herbicidal composition containing at least one compound selected from Group A, dicamba or agronomically acceptable salt thereof and isoxadifen-ethyl as active ingredients has a weed control effect:
| 2013-10-17 |
20130274107 | HERBICIDAL COMPOSITION - To provide a technology for controlling weeds and the like. A herbicidal composition containing at least one compound selected from Group A, tembotrione and isoxadifen-ethyl as active ingredients has a weed control effect:
| 2013-10-17 |
20130274108 | READIED IN SITU GLYPHOSATE HERBICIDE SOLUBLE POWDER COMPOSITION AND ITS PREPARATION PROCESS - This invention relates to a readied in situ glyphosate herbicide soluble powder composition of high efficiency and low toxicity useful for killing and/or controlling weeds. This invention is also related to a process to prepare the said composition. It is another object of this invention to provide a new composition that consists of a soluble powder herbicide formulation characterized by a very narrow range of specific ingredients of composition, which optimizes the formulation efficiency and minimizes the cost and toxicity to man, to the environment and to the crop being treated. The required amount of glyphosate that needs to be applied on the field is reduced by 30% when compared to the commercially standard liquid solution. | 2013-10-17 |
20130274109 | Substituted Pyrazines Having Herbicidal Activity - The present invention provides substituted pyrazine compounds of the formula I | 2013-10-17 |
20130274110 | HYDROPHOBICALLY MODIFIED POLYSACCHARIDE ETHERS AS DEPOSITION ENHANCERS FOR AGRICULTURAL ACTIVE INGREDIENTS - A composition is provided, comprising a non-ionic, water-soluble, hydrophobically modified lower alkyl hydroxyalkyl linear polysaccharide ether, wherein the hydrophobic group comprises a long-chain C10-C18 alkyl or alkenyl group, the lower alkyl group has 1-4 carbon atoms, and the hydroxyalkyl groups are hydroxyethyl and/or hydroxypropyl; and one or more agriculturally active ingredient. A method for treating a plant is also provided, comprising the step of contacting a plant with a composition of the invention. | 2013-10-17 |
20130274111 | Method and device for rapid DNP - A method for producing hyperpolarized sample material for use in magnetic resonance investigations involves preparing a target material containing high γ nuclei with a short T | 2013-10-17 |
20130274112 | LIGAND SCREENING AND DISCOVERY - Disclosed is a method that includes: (i) providing a plurality of initial nucleic acid cassettes that include: a) a first coding region encoding a first immunoglobulin variable domain, b) a second coding region encoding a second immunoglobulin variable domain, and c) a ribosomal binding site disposed between the first and second coding regions for translation of the second polypeptide in a first expression system, wherein the first and second coding regions are in the same translational orientation; (ii) modifying each nucleic acid cassette of the plurality in a single reaction mixture so that it is functional in a second expression system, wherein the first and second region remain physically attached during the modifying; (iii) introducing each modified nucleic acid cassette into a mammalian cell to produce a mixture of transfected cells; and (iv) expressing each modified nucleic acid cassette in the transfected cells. | 2013-10-17 |
20130274113 | MULTIPLEX MICROFLUIDIC DEVICE FOR SELECTING NUCLEIC ACID APTAMERS, AND HIGH THROUGHPUT SELECTION METHOD FOR NUCLEIC ACID APTAMERS USING SAME - The present invention relates to a multiplex microfluidic device for selection of nucleic acid aptamers and a method for high-throughput selection of nucleic acid aptamers using the same, and more particularly to a multiplex microfluidic device (SELEX lap-on-a-chip) that uses an improved multiplex platform in place of the development of an aptamer for a single target and to a method for high throughput selection of aptamers using the same together with high-throughput sequencing. A multiplex microfluidic device according to the present invention can simultaneously detect aptamers for a plurality of targets, and it can greatly increase the screening throughput and greatly shorten the process time compared to conventional multiplex techniques. Particularly, when a process for selecting aptamers is performed using the device of the invention together with a high-throughput sequencing method, the number of target binding/elution/amplification rounds can be greatly reduced, and the process can be performed in an automated manner. Thus, the device of the invention is highly useful. | 2013-10-17 |
20130274114 | MULTIPOTENT STEM CELL-BASED CULTURE SYSTEMS AND MODELS - This invention generally relates to multipotent stem cell-based research tools. More particularly, the present invention relates to culture systems and 3-dimensional tissue models that may be used for identifying agents useful for treating diseases and conditions and that are suitable for high throughput screening applications. This present invention is based, in part, on the discovery of a method for propagating multipotent stem cells from human skin fibroblasts and subsequently differentiating those multipotent stem cells into cells of any of the three germ layers. Aspects of the invention include drug discovery tools as a high throughput screen; 3-dimensional tissue engineering model, and drug discovery tools thereof; research tools for identifying genes that are important for acquiring multipotency and for identifying genes that are important for lineage-specific differentiation, and drug discovery tools thereof; diagnostic tools for identifying defective genes; and autologous therapies based on the propagated multipotent stem cells. | 2013-10-17 |
20130274115 | METHOD FOR PAIRWISE SEQUENCING OF TARGET POLYNUCLEOTIDES - The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template. Using the methods of the invention it is possible to obtain two linked or paired reads of sequence information from each double-stranded template on a clustered array, rather than just a single sequencing read from one strand of the template. | 2013-10-17 |
20130274116 | METHODS FOR NON-INVASIVE PRENATAL PLOIDY CALLING - Disclosed herein are methods for determining the copy number of a chromosome in a fetus in the context of non-invasive prenatal diagnosis. In an embodiment, the measured genetic data from a sample of genetic material that contains both fetal DNA and maternal DNA is analyzed, along with the genetic data from the biological parents of the fetus, and the copy number of the chromosome of interest is determined. In an embodiment, the maternal serum is measured using a single-nucleotide polymorphism (SNP) microarray, along with parental genomic data, and the determination of the chromosome copy number is used to make clinical decisions pertaining to the fetus. | 2013-10-17 |
20130274117 | High-Throughput Single Cell Barcoding - Methods and compositions for high-throughput, single cell analyses are provided. The methods and compositions can be used for analysis of genomes and transcriptomes, as well as antibody discovery, HLA typing, haplotyping and drug discovery. | 2013-10-17 |
20130274118 | COMBINATORIAL PROBE LIBRARIES - Provided herein is a set of reagents comprising: a plurality of at least three probe libraries, wherein each library of the plurality comprises one or more probe sets that are each specific for a target; and at least one of the libraries comprises a probe set that is present in another of the libraries. The plurality of libraries can be hybridized to spatially separated targets, simultaneously or sequentially. The identity of a spatially separated target can be determined by identifying which combination of the multiple libraries hybridize thereto. | 2013-10-17 |
20130274119 | METHODS AND APPARATUSES FOR DETECTION OF POSITIONAL FREEDOM OF PARTICLES IN BIOLOGICAL AND CHEMICAL ANALYSES AND APPLICATIONS IN IMMUNODIAGNOSTICS - The present invention relates to methods and apparatuses for the detection of positional freedom of particles used in biological, biochemical, physical, biophysical, and chemical analyses. In particular, the present invention relates to methods and apparatuses which can detect and characterize a population of particles/cells based upon their detected mobility. In one embodiment consistent with the invention, detection of certain cells is based on differences detected in populations of cells that bind to a substrate and those that exhibit weaker binding forces. Initially, cells are settled on the substrate, and in the presence of gravitational, natural thermodynamic pressure fluctuations, and other random or applied forces, some of the particles may exhibit translational movement. Particle movement is detected, and measurements are computed, according to the methods and apparatuses of the present invention, to determine the binding of specific analytes. | 2013-10-17 |
20130274120 | METHODS AND USES RELATING TO THE IDENTIFICATION OF COMPOUND INVOLVED IN PAIN AS WELL AS METHODS OF DIAGNOSING ALGESIA - The present invention relates to a method of identifying a compound involved in pain, the use of Ms4a6d nucleic acid or Ms4a6d protein for identifying a compound involved in pain as well as methods of diagnosing algesia involving the same. | 2013-10-17 |
20130274121 | Diagnostic Method - The present invention relates to a multiplex in vitro nucleic acid amplification method for identifying a species of the | 2013-10-17 |
20130274122 | ASSAY FOR CHLAMYDIA TRACHOMATIS BY AMPLIFICATION AND DETECTION OF CHLAMYDIA TRACHOMATIS PMPA GENE - A region of the | 2013-10-17 |
20130274123 | MATERNAL BIOMARKERS FOR GESTATIONAL DIABETES - Embodiments herein relate to the field of screening tools for fetal/maternal wellness, and, more specifically, to biomarkers for gestational diabetes. In various embodiments, the methods may provide non-invasive and minimally-invasive screening tools for gestational diabetes that involve detection of changes in a proteomic profile of a test sample relative to a reference sample. In particular embodiments, the method may include determining whether a proteomic profile of a test sample from the subject includes at least one expression signature characteristic of gestational diabetes, wherein the proteomic profile comprises information on the expression of glycosylated fibronectin and glycosylated PSG, for example information on levels of fibronectin-SNA or a fibronectin-antibody complex, and PSG-AAL or a PSG-antibody complex. In some embodiments, the proteomic profile may also include information on the expression of adiponectin, sex hormone binding globulin (SHBG), C-reactive protein (CRP), a ratio of human chorionic gonadotropin (hCG) to placental lactogen, or a combination thereof. | 2013-10-17 |
20130274124 | ADHESION SIGNATURES - The present invention provides arrays comprising polypeptides associated with extracellular matrix that can be used to isolate, differentiate, or culture certain cell types including stem cells, cancer cells, and/or primary hepatocytes. The array comprises at least a pair of polypeptides that comprise a polypeptide associated with extracellular matrix or functional fragments thereof. The invention also provides for methods of diagnosing and/or prognosing a certain disease or disorder through contacting a cell sample from a patient with an array comprising at least a pair of polypeptides that comprise a polypeptide sequence associated with extracellular matrix or functional fragments thereof. | 2013-10-17 |
20130274125 | MULTIPLEX IMMUNOASSAY FOR RHEUMATOID ARTHRITIS AND OTHER AUTOIMMUNE DISEASES - Rheumatoid arthritis and other autoimmune diseases are diagnosed by multiplex assays for antibodies to a panel of antigens that includes cyclic citrullinated peptide and at least five members of a list that includes BRAF1 506-525, BRAF2 656-675, Vimentin (protein) citrullinated, Vimentin 415-433 cit cyclic, Vimentin 58-77 cit3 cyclic, Clusterin 231-250 cit sm1 cyclic, Fibrinogen A 556-575 cit sm cyclic, Fibrinogen A 616-635 cit sm cyclic, Histones2A H2A/a 1-20 cit sm2 cyclic, Filaggrin 48-65 cit2v1 cyclic, BRAF (catalytic domain from v raf murine sarcoma viral oncogene homologue B1, amino acids 416-766). | 2013-10-17 |
20130274126 | SENSOR CHIP AND MEASUREMENT METHOD USING THE SAME - Provided is a device that can detect cells or bacteria in units of a single cell or bacterium, and can further measure the amounts of activity of cells or bacteria or responses of the cells or bacteria to drugs in units of a single cell or bacterium. A plurality of partitioned regions each having about the same size as a cell or a bacterium is provided, and a plurality of types of electrical sensors | 2013-10-17 |
20130274127 | GENE EXPRESSION MARKERS FOR PREDICTION OF RESPONSE TO PHOSPHOINOSITIDE 3-KINASE INHIBITORS - The present invention provides methods for predicting a likelihood that a tumor cell will be sensitive or resistant to a phosphoinositide 3-kinase (PI3K) inhibitor. The methods generally involve determining an expression level of a gene product that correlates with sensitivity or resistance to a PI3K inhibitor. The present invention also provides methods for increasing sensitivity of a tumor cell to a PI3K inhibitor by contacting the tumor cell with an activator or inhibitor of a gene product that correlates with sensitivity or resistance to a PI3K inhibitor. | 2013-10-17 |
20130274128 | GENE EXPRESSION IN N-CADHERIN OVEREXPRESSING PROSTATE CANCERS AND THEIR CONTROLS - The present invention provides methods of diagnosing a cancer or providing a prognosis for a cancer by analyzing the level of expression of a marker that is a downstream target of N-cadherin. | 2013-10-17 |
20130274129 | TAL-EFFECTOR ASSEMBLY PLATFORM, CUSTOMIZED SERVICES, KITS AND ASSAYS - The invention generally relates to compositions and methods for designing and producing functional DNA binding effector molecules and associated customized services, tool kits and functional assays. In some aspects, the invention provides methods and tools for efficient assembly of customized TAL effector molecules. Furthermore, the invention relates to uses of TAL effector molecules and functional evaluation of such TAL by, for example, customized assays. | 2013-10-17 |
20130274130 | SENSITIVE HIGH THROUGHPUT METHOD FOR DNA DAMAGE AND REPAIR - A high throughput method and apparatus for rapidly screening a plurality of genotoxicants to determine the degree and type of genotoxicity are provided. | 2013-10-17 |
20130274131 | Advanced Reverse-phase Magnetic Immunoassay - A magnetic assay is provided where capture probes are disposed on the sensor array as capture probe spots that overlap with the sensor elements. The capture probes on the sensor elements can be the same or they can be different. Two or more sample solutions are also disposed on the sensor array as sample spots that overlap with the sensor elements. Targets in the sample solutions can bind to the capture probes to provide immobilized targets. Magnetically labeled probes capable of binding to targets are provided to the assay, and the resulting assay signal is from immobilized magnetically labeled probes at the sensor elements. | 2013-10-17 |
20130274132 | Genetic Modifiers of Cystic Fibrosis - Disclosed herein are compositions and methods for and treating Cystic Fibrosis lung disease severity and/or secondary manifestations, including meconium ileus and CF related liver disease. | 2013-10-17 |
20130274133 | GENETIC VARIATIONS IN THE INTERLEUKIN-6 RECEPTOR GENE AS PREDICTORS OF THE RESPONSE OF PATIENTS TO TREATMENT WITH INTERLEUKIN-6 RECEPTOR INHIBITORS - The present invention relates to a method for predicting the response of patients to treatment with Interleukin-6 Receptor (IL6R) inhibitors, such as antibodies directed against the IL6R. The method comprises the analysis of one or more genetic variations, in particular single nucleotide polymorphisms, in or associated with the Interleukin-6 Receptor gene. The present invention further relates to a kit for use in predicting the response of patients to treatment with IL6R inhibitors, such as Tocilizumab. The patients suffers from rheumatoid arthritis. | 2013-10-17 |
20130274134 | Analytical Methods and Arrays for Use in the Same - The present invention relates to an in vitro method for identifying agents capable of inducing sensitization of human skin and arrays and diagnostic kits for use in such methods. In particular, the methods include measurement of the expression of the biomarkers listed in Table 3A and/or 3B in MUTZ-3 cells exposed to a test agent. | 2013-10-17 |
20130274135 | COMPOSITIONS OF TOEHOLD PRIMER DUPLEXES AND METHODS OF USE - Provided herein are primers and primer systems having improved specificity and kinetics over existing primers, and methods of use thereof. | 2013-10-17 |
20130274136 | PROSTATE CANCER POINT OF CARE DIAGNOSTICS - The invention relates to point of care diagnostic disposables, devices, methods, and systems for diagnosing or predicting prostate cancer. The present invention employs biomarker specific reagents in disposable cassettes or lab cards for use as analyzers, as well as software to evaluate and report test results. The system promises to improve point of care in vitro diagnostics. | 2013-10-17 |
20130274137 | METHOD AND SYSTEM FOR DETECTING A TARGET WITHIN A POPULATION OF MOLECULES - A method of detecting a target within a population of molecules comprising: contacting a plurality of labeled probe molecules with the population of molecules potentially containing a target of the probe molecules; acquiring a probe specific signal emitted by said labeled probe molecules that bound to said target together with a background signal; preferentially modulating said probe specific signal by at least one of modulating said acquisition and modulating an emission of said probe specific signal; and detecting said probe specific signal over said background signal using said preferential modulation. | 2013-10-17 |
20130274138 | GENE SIGNATURES FOR PREDICTION OF THERAPY-RELATED MYELODYSPLASIA AND METHODS FOR IDENTIFICATION OF PATIENTS AT RISK FOR DEVELOPMENT OF THE SAME - In one embodiment, a gene expression signature for predicting risk of developing therapy-related myelodysplasia or acute myeloid leukemia (t-MDS/AML) after autologous hematopoietic cell transplantation (aHCT) is provided. In another embodiment, a method for predicting a risk for development of t-MDS/AML after aHCT is provided. Such a method may include providing a biological sample that contains CD34 cells from a subject; detecting a test expression level of a set of two or more genes of a gene expression signature; comparing the test expression level of a set of corresponding training expression levels that include a training case expression level and a training control expression level; and predicting a high risk of developing t-MDS/AML when the test expression level is at or about the training case expression level or predicting a low risk of developing t-MDS/AML when the test expression level is at or about the training control expression level. | 2013-10-17 |
20130274139 | MODULAR POINT-OF-CARE DEVICES, SYSTEMS, AND USES THEREOF - The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications. | 2013-10-17 |
20130274140 | MicroRNA Fingerprints During Human Megakaryocytopoiesis - Described herein are methods of diagnosing a cancer and/or myeloproliferative disorder using microRNAs. Also described are compositions and methods related to cancers and myeloproliferative disorders. | 2013-10-17 |
20130274141 | METHODS AND KITS FOR SYNTHESIS OF siRNA EXPRESSION CASSETTES - Amplification-based methods and kits for rapidly producing siRNA expression cassettes are provided. Also provided are methods for expressing amplified siRNA expression cassettes in cells. | 2013-10-17 |
20130274142 | Cell Co-Culture Systems and Uses Thereof - The invention provides a cell co-culture for the selective evaluation of the response of a cell of interest in the co-culture, and methods of using the co-culture. The cell co-culture and the methods are suitable for large-scale/high throughput screening for compounds useful for affecting at least one biological function or event of at least one cell type in the co-culture. The invention further provides kits for using the screening assays. | 2013-10-17 |
20130274143 | USE OF DETECTOR RESPONSE CURVES TO OPTIMIZE SETTINGS FOR MASS SPECTROMETRY - Processes for identifying optimal mass spectrometer settings to produce the greatest confidence in sample constituent detection are provided. Data obtained on a mass spectrometer are analyzed by a quadratic variance function which accurately represents intensity variation as a variation of peak intensity. This function is then used to identify intensities that possess a minimum coefficient of variation that is useful for identifying optimal mass spectrometer settings. Inventive processes involve using a general purpose computer to identify optimal mass spectrometer settings for use in biomarker analyses, for optimizing peak detection and biomarker identification in a biological sample. The inventive processes provide for improved methods of identifying new biomarkers as well as screening subjects for the presence or absence of disease or biological condition. | 2013-10-17 |
20130274144 | COMPOUNDS, REACTIONS, AND SCREENING METHODS - The invention provides a method comprising identifying a successful metal-mediated conjugation reaction by analyzing a test mixture for the presence of a conjugation product. The invention provides a two-dimensional approach to reaction discovery in which many catalysts for many catalytic reactions can be tested simultaneously to provide an efficient discovery platform. Reactants and products from the system can be identified using techniques such as gas chromatography, liquid chromatography, mass spectrometry, and combinations thereof. | 2013-10-17 |
20130274145 | Anti-TNF Alpha Fibronectin Type III Domain Based Scaffold Compositions, Methods and Uses - A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, preferably human Tenascin, that binds to human TNFα including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. | 2013-10-17 |
20130274146 | CAPTURE REACTIONS - The invention generally relates to methods of performing a capture reaction. In certain embodiments, the method involves obtaining a nucleic acid, fragmenting the nucleic acid, and capturing a target sequence on the nucleic acid fragment using a capture moiety, such as a molecular inversion probe. | 2013-10-17 |
20130274147 | INTEGRATED SAMPLE PREPARATION SYSTEMS AND STABILIZED ENZYME MIXTURES - The present invention provides integrated sample preparation systems and stabilized enzyme mixtures. In particular, the present invention provides microfluidic cards configured for processing a sample and generating DNA libraries that are suitable for use in sequencing methods (e.g., next generation sequencing methods) or other suitable nucleic acid analysis methods. The present invention also provides stabilized enzyme mixtures containing an enzyme (e.g., an enzyme used in whole genome amplification), BSA, and a sugar. Such enzyme mixtures may be lyophilized and stored at room temperature without significant loss of enzyme activity for months. | 2013-10-17 |
20130274148 | PORTABLE GENETIC DETECTION AND ANALYSIS SYSTEM AND METHOD - A portable detector is disclosed for detecting certain analytes of interest, such as genetic material (e.g., nucleic acids). The detector includes a reading component for the detection of the analytes, and control circuitry for controlling operation of the reading component. Processing circuitry may be included to perform both primary analysis of acquired data, and where desired, secondary analysis. Where desired, some or all of the computationally intensive tasks may be off-loaded to enhance the portability and speed of the device. The device may incorporate various types of interface, technologies for reading and analysis, positioning system interfaces, and so forth. A number of exemplary use cases and methods are also disclosed. | 2013-10-17 |
20130274149 | FLUIDS AND METHODS INCLUDING NANOCELLULOSE - Treatment fluids and methods for treating a subterranean formation are disclosed that include introducing a treatment fluid into a subterranean formation, the treatment fluid containing a nanocrystalline cellulose. | 2013-10-17 |
20130274150 | LIGNOSULFONATE GRAFTS WITH AN ACID, ESTER AND NON-IONIC MONOMERS - The present invention generally relates to controlling the viscosity of water-based mud systems. More particularly, the present invention relates to methods and compositions for thinning and deflocculating aqueous based fluids used in well drilling and other well operations in subterranean formations, especially subterranean formations containing oil and/or gas. The invention also relates to a drilling fluid thinner and/or dispersant having improved temperature stability, dispersing properties and “solids contamination” tolerance. | 2013-10-17 |
20130274151 | AGGREGATING COMPOSITIONS, MODIFIED PARTICULATE METAL-OXIDES, MODIFIED FORMATION SURFACES, AND METHODS FOR MAKING AND USING SAME - A method for treating solid materials is disclosed, where the treating compositions coats surfaces or portions of surfaces of the solid materials changing an aggregation or agglomeration propensity of the materials. Treating composition and treated solid materials are also disclosed. The methods and treated materials are ideally suited for oil field applications. | 2013-10-17 |
20130274152 | POLYSACCHARIDE SLURRIES WITH ENVIRONMENTALLY FRIENDLY ACTIVATOR SOLVENTS - A stable polysaccharide particle suspension composition comprising: a carrier; an activator solvent comprising a) at least one dibasic methyl or ethyl ester; b) at least one compound of the formula R | 2013-10-17 |
20130274153 | ALKALI-ACTIVATED COATINGS FOR PROPPANTS - The present invention relates to proppants and the manufacture of proppants by contacting a substrate with an alkali-activated composition that cures to form a continuous polymer coating. | 2013-10-17 |
20130274154 | PROCESS AND FLUID TO IMPROVE THE PERMEABILITY OF SANDSTONE FORMATIONS USING A CHELATING AGENT - The present invention relates to a process for treating a sandstone formation comprising introducing a fluid containing glutamic acid N,N-diacetic acid or a salt thereof (GLDA) and having a pH of between 1 and 14 into the formation. The invention in addition relates to a fluid and a kit of parts suitable for use in the above process containing glutamic acid N,N-diacetic acid or a salt thereof (GLDA), a corrosion inhibitor, a surfactant, and optionally a mutual solvent. | 2013-10-17 |
20130274155 | PROCESS TO CONTROL IRON IN OIL AND GAS APPLICATIONS USING A CHELATING AGENT - The present invention relates to a process to control iron in a subterranean formation wherein a fluid containing glutamic acid N,N-diacetic acid or a salt thereof (GLDA) and/or methylglycine N,N-diacetic acid or a salt thereof (MGDA) is introduced into the formation at a temperature between 77 and 400° F. (about 2 and 204° C.). The invention also covers a process of treating a subterranean formation wherein simultaneously iron control takes place. | 2013-10-17 |
20130274156 | LOW INTERFACIAL TENSION SURFACTANTS FOR PETROLEUM APPLICATIONS - The invention relates to a class of novel surfactants that have utility in the recovery and/or extraction of oil. | 2013-10-17 |
20130274157 | LUBRICATING COMPOSITION AND METHOD FOR THE PREPARATION THEREOF - The invention relates to lubricating compositions and methods for producing same. The lubricating composition comprises a lubricating medium and the product of dehydration of natural minerals or a mixture of natural minerals, or of synthesized hydrates. | 2013-10-17 |
20130274158 | Lubricating Oil Compositions - An internal combustion engine crankcase lubricating oil composition having a sulphated ash content of no greater than 1.2 mass %, based on the mass of the lubricating oil composition, and a phosphorous content of no greater than 0.1 mass %, based on the mass of the lubricating oil composition, which lubricating oil composition comprises or is made by admixing:
| 2013-10-17 |
20130274159 | DRY LUBRICANT CONTAINING FIBERS AND METHOD OF USING THE SAME - A dry lubricant comprises at least 50 wt % of fibers having a diameter between 50 nm and 10 microns and a length that is at least 5 times the diameter. | 2013-10-17 |
20130274160 | Amine Terminated and Hydroxyl Terminated Polyether Dispersants - The disclosed technology relates to a dispersant composition comprising the reaction product of a polyolefin acylating agent and an amine terminated or hydroxyl terminated polyether. In addition, the technology relates to lubricating compositions containing the dispersant composition and an optional synergistic amount of another dispersant, as well as methods of employing the dispersant composition in an engine and engine oils. | 2013-10-17 |
20130274161 | Lubricating Oil Compositions - An additive package for an internal combustion engine crankcase lubricating oil composition, which additive package comprises or is made by admixing:
| 2013-10-17 |
20130274162 | Lubricating Composition Containing A Detergent - The invention provides a lubricating composition containing an oil of lubricating viscosity and a detergent. The invention further relates to a process to prepare the detergent, and the use of the lubricating composition in a mechanical device such as an internal combustion engine, or a driveline device. | 2013-10-17 |
20130274163 | LUBRICANT OIL COMPOSITION FOR COMPRESSION REFRIGERATOR - It is to provide a lubricating oil composition for a compression refrigerator, which is excellent in the thermal/chemical stability even when used in a compression refrigerator that uses a saturated fluorinated hydrocarbon refrigerant having a lower global warming potential and a fewer carbon atoms, by including in a base oil an organic compound having a double bond in a molecule, which is at least one kind selected from an organic compound having at least two non-conjugated double bonds in the molecule, a terpene compound having a double bond in the molecule, and C | 2013-10-17 |
20130274164 | Method and Composition for Removing Latex Paint - Disclosed is a paint removing composition including an aluminum containing salt, calcium hydroxide, and calcium sulfate. When applied to wet latex paint, the composition neutralizes the paint molecules and causes the colloid to come out of suspension by the process of flocculation. The composition is prepared as a dry powder and added to a sufficient amount of water to create an aqueous solution. Also disclosed is a method of cleaning paintbrush containing wet paint. The composition is placed in contact with a wet paint-containing paintbrush for a sufficient time to cause the paint to come out of suspension in the form of floc. | 2013-10-17 |
20130274165 | ACIDIC MICROEMULSION STRIPPING FORMULATIONS - Described are stripper compositions, comprising an acidic microemulsion, said microemulsion comprising C | 2013-10-17 |
20130274166 | NON-CORROSIVE STRIPPING COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME - Provided are compositions suitable for stripping coatings from a surface. The compositions may include a solvent and an organic functional amine. The solvent may be benzyl alcohol. The compositions may further include at least one chelant. The compositions may be non-corrosive to eyes or skin or both. Also provided are methods of stripping a coating from a surface, the method including applying to the surface a composition according to the disclosure. | 2013-10-17 |
20130274167 | CLEANING COMPOSITION FOR DISHWASHING - A cleaning composition comprises the reaction product of A) a chelating component and B) an acidic component different from the chelating component. The chelating component is selected from the group of methylglycine-N-N-diacetic acid (MGDA), N,N-bis(carboxymethyl)-L-glutamate (GLDA), nitrilotriacetic acid (NTA), hydroxyethylethylenediaminetriacetic acid (HEDTA), ethylenediaminetetraacetic acid (EDTA), diethylenetriaminepentaacetic acid (DTPA), and mixtures thereof. The chelating component is generally a salt or a partial-salt of the respective acid, e.g. Na | 2013-10-17 |
20130274168 | HIGH ALKALINE DETERGENT COMPOSITION WITH ENHANCED SCALE CONTROL - A detergent composition for preventing scale on various surfaces includes a threshold system, a caustic and a surfactant system. The threshold system includes a sulfonate/acrylate copolymer, an acrylate homopolymer and a phosphonoalkane carboxylic acid with a sulfonate/acrylate copolymer to acrylate homopolymer weight ratio of between about 2:1 to about 1:2. The pH of the detergent composition is between about 10 and about 13. | 2013-10-17 |
20130274169 | ETHYLENE ACRYLIC ACID COPOLYMER AQUEOUS DISPERSIONS FOR FRAGRANCE RELEASE IN LAUNDRY DETERGENTS - Described are fabric care compositions, comprising a builder and an aqueous dispersion comprising an ethylene acrylic acid copolymer and a fragrance. | 2013-10-17 |
20130274170 | Compositions of viscoelastic surfactant and hydrophobically modified polymer as aqueous thickeners - An aqueous viscoelastic composition is provided comprising at least one viscoelastic surfactant, and at least one hydrophobically modified polymer, which is formed from polymerization of ethylenically unsaturated monomers; has a number average molecular weight of from 1,000 to 100,000 Da; and to a level of at least 0.1 mole %, based on the amount of monomer units in the polymer, contains monomeric units each covalently bonded to a pendant, optionally alkoxylated, hydrocarbyl group having from 6 to 40 carbon atoms, said pendant, optionally alkoxylated, hydrocarbyl group being connected to the backbone of said hydrophobically modified polymer via a non-ester containing linking group. | 2013-10-17 |
20130274171 | TREFOIL FACTORS (TFF) FOR THE TREATMENT OF CHRONIC PULMONARY DISEASES - The present invention provides methods for enhancing or inducing airway epithelial repair and/or regeneration and/or for the normalization of airway epithelial remodeling, using local deposition of one or more pro-regenerative factors, preferably a peptide or protein from the trefoil family factor (TFF) family. The pro-regenerative factor is administered to a patient as a treatment of Chronic obstructive pulmonary disease (COPD), chronic bronchitis, Cystic fibrosis, Asthma, Bronchiectasis, Panbronchiolitis, pneumonia, ventilator associated pneumonia (VAP), hospital acquired pneumonia (HAP), community acquired pneumonia (CAP), severe community acquired pneumonia (sCAP) and | 2013-10-17 |
20130274172 | SINGLE DOMAIN TDF-RELATED COMPOUNDS AND ANALOGS THEREOF - The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders. | 2013-10-17 |
20130274173 | STABLE HELICAL IONIC POLYPEPTIDES - The invention provides polymers comprising Formula I: | 2013-10-17 |
20130274174 | THERAPEUTIC COMBINATION OF DAPTOMYCIN AND PROTEIN SYNTHESIS INHIBITOR ANTIBIOTIC, AND METHODS OF USE - A therapeutic combination comprises an antibacterially effective amount of daptomycin, and an amount of protein synthesis inhibitor antibiotic effective to prevent the development of daptomycin non-susceptibility in bacteria. Related combination therapies and methods are also included. | 2013-10-17 |
20130274175 | TREATMENT OF DISEASE ASSOCIATED WITH THE USE OF ANTIBIOTICS - This invention relates to the treatment or prevention of diseases associated with the use of antibiotics or cancer chemotherapies or antiviral therapies, such as colitis, pseudomembranous colitis, antibiotic associated diarrhea and infections due to | 2013-10-17 |
20130274176 | BETA-ARRESTIN EFFECTORS AND COMPOSITIONS AND METHODS OF USE THEREOF - This application describes a family of compounds acting as β-arrestin effectors. Such compounds may provide significant therapeutic benefit in the treatment of chronic and acute cardiovascular diseases. | 2013-10-17 |
20130274177 | MAMMALIAN COLOSTRUM DERIVED NANOPEPTIDES FOR BROADSPECTRUM VIRAL AND RECURRENT INFECTIONS WITH A METHOD OF ISOLATION THEREOF - The present Invention relates to nanopeptides isolated from mammalian colostrums with vaccine like antiviral and immunodulator activity via building body's own immune system and attachment inhibition on the cell surface receptors. | 2013-10-17 |
20130274178 | Active Cores of Peptide Triazole HIV-1 Entry Inhibitors - The invention provides a peptide triazole conjugate and derivatives thereof, and methods of its use. The invention also provides an antibody to the peptide triazole conjugate. The invention further provides a method of identifying an HIV-1 entry inhibitor candidate. | 2013-10-17 |